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Journal articles on the topic 'Flexible amide ligands'

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Author: Grafiati

Published: 10 December 2022

Last updated: 28 January 2023

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1

Wang, Xiu-Li, Dan-Na Liu, Hong-Yan Lin, Guo-Cheng Liu, Na Han, Jian Luan, and Zhi-Han Chang. "Application of flexible bis-pyrazine–bis-amide ligands to construct various polyoxometalate-based metal–organic complexes." RSC Advances 5, no. 70 (2015): 56687–96. http://dx.doi.org/10.1039/c5ra09529h.

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Five novel polyoxometalates-based metal–organic complexes constructed from different types of polyanions and flexible bis-pyrazine–bis-amide ligands with different spacer lengths have been hydrothermally synthesized and structurally characterized.

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2

Thapa, Kedar Bahadur, and Jhy-Der Chen. "Crystal engineering of coordination polymers containing flexible bis-pyridyl-bis-amide ligands." CrystEngComm 17, no. 25 (2015): 4611–26. http://dx.doi.org/10.1039/c5ce00179j.

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3

Wang, Xiu-Li, Peng Liu, Jian Luan, Hong-Yan Lin, and Chuang Xu. "The Role of the Coordination Modes of a Flexible Bis(pyridylamide) Ligand in the Topology of 2D Copper(II) Complexes." Zeitschrift für Naturforschung B 67, no. 9 (September 1, 2012): 877–86. http://dx.doi.org/10.5560/znb.2012-0179.

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Two new two-dimensional copper(II) coordination polymers, [Cu(L)(BDC)]_H2O (1) and [Cu2(L)0:5(SIP)(OH)(H2O)] 2H2O (2) [L=N;N0-bis(3-pyridylamide)-1,6-hexane, H2BDC=1,3- benzenedicarboxylic acid, H3SIP=5-sulfoisophthalic acid (3,5-dicarboxybenzenesulfonic acid)], have been synthesized hydrothermally by self-assembly of the flexible bis-pyridyl-bis-amide ligand L and the aromatic polycarboxylate ligands H2BDC or H3SIP. X-Ray diffraction analysis reveals that complex 1 displays a metal-organic coordination layer with a binodal (3,5)-connected {42.67.8}{42.6} topology, in which the L ligands adopt a m2-bridging mode (via ligation of the pyridyl nitrogen atoms). Complex 2 also exhibits a layered network based on tetranuclear copper clusters [Cu4(μ3-OH)2(H2O)2(O2C-)4], L ligands and SIP anions, showing a binodal (4,8)-connected network with {414.610.84}{44.62} topology, in which the L ligands adopt a μ6-bridging coordination mode (via ligation of the pyridyl nitrogen and carbonyl oxygen atoms). Adjacent layers in 1 and 2 are further linked by hydrogen bonding interactions to form three-dimensional supramolecular frameworks. The electrochemical behavior of the two complexes in bulk-modified carbon paste electrodes has been investigated

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4

Salzmann, Kevin, Candela Segarra, and Martin Albrecht. "Donor‐Flexible Bis(pyridylidene amide) Ligands for Highly Efficient Ruthenium‐Catalyzed Olefin Oxidation." Angewandte Chemie 132, no. 23 (March 25, 2020): 9017–21. http://dx.doi.org/10.1002/ange.202002014.

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5

Salzmann, Kevin, Candela Segarra, and Martin Albrecht. "Donor‐Flexible Bis(pyridylidene amide) Ligands for Highly Efficient Ruthenium‐Catalyzed Olefin Oxidation." Angewandte Chemie International Edition 59, no. 23 (March 25, 2020): 8932–36. http://dx.doi.org/10.1002/anie.202002014.

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6

Elisi, Gian Marco, Annalida Bedini, Laura Scalvini, Caterina Carmi, Silvia Bartolucci, Valeria Lucini, Francesco Scaglione, Marco Mor, Silvia Rivara, and Gilberto Spadoni. "Chiral Recognition of Flexible Melatonin Receptor Ligands Induced by Conformational Equilibria." Molecules 25, no. 18 (September 4, 2020): 4057. http://dx.doi.org/10.3390/molecules25184057.

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N-anilinoethylamides are a class of melatoninergic agents with the aniline portion mimicking the indole ring of the natural ligand and the ethylamide chain reproducing that of melatonin. The simplest compound in this class, N-{2-[(3-methoxyphenyl)methylamino]ethyl}acetamide (UCM793), has nanomolar binding affinity for MT1 and MT2 membrane receptors. To explore the effect of chain conformation on receptor binding, a methyl group was inserted on the methylene alpha or beta to the amide nitrogen and conformational equilibria were investigated by NMR spectroscopy and molecular dynamics simulations. Receptor affinity was conserved only for the beta-methyl derivative, which also showed significant stereoselectivity, with the (S) enantiomer being the eutomer. Molecular dynamics simulations, validated by NMR spectroscopy, showed that the beta-methyl group affects the conformational preferences of the ethylamide chain. Docking into the receptor crystal structure provides a rationale for the observed chiral recognition, suggesting that the (S)-beta-methyl group favors the conformation that better fits the receptor binding site.

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7

Bai, Hong-Ye, Wei-Qiang Fan, Chun-Bo Liu, Wei-Dong Shi, and Yong-Sheng Yan. "Synthesis, structure and electrochemical behavior of a 3D crystalline copper(II) metal-organic framework." Functional Materials Letters 07, no. 04 (August 2014): 1450049. http://dx.doi.org/10.1142/s1793604714500490.

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Using an flexible amide-type tripodal ligand N , N ′, N ″-tris(3-pyridyl)-1,3,5-benzenetricarboxamide (L) and 1,4-benzenedicarboxylic acid ( H 2 bdc ), a three-dimensional copper(II) metal-organic framework (MOF) formulated as [ Cu ( bdc )( L )]n has been hydrothermally synthesized and structurally characterized by IR, elemental, X-ray single-crystal diffraction and thermal analysis. The complex crystallizes in the triclinic, space group P - 1, a = 8.891(2) Å, b = 11.760(2) Å, c = 15.348(3) Å, α = 96.73(3)°, β = 105.96(3)°, γ = 106.47(3)°, V = 1446.2(5) Å3, Mr = 666.10, Dc = 1.530 g/cm3, Z = 2, F(000) = 682, GOOF = 1.0560, μ(MoKα) = 0.817 mm-1, R = 0.0366 and wR = 0.0885. The structural analyses reveal that the title compound consists of one Cu ( II ) atom, two halves of bdc, and one L ligand. Each Cu ( II ) atom is linked by two bdc ligands and three L ligands to form a three-dimensional network. In addition, the electrochemical behavior of title compound has been studied. CCDC No. 990526.

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8

Thapa, Kedar Bahadur, and Jhy-Der Chen. "ChemInform Abstract: Crystal Engineering of Coordination Polymers Containing Flexible Bis-pyridyl-bis-amide Ligands." ChemInform 47, no. 8 (February 2016): no. http://dx.doi.org/10.1002/chin.201608231.

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9

Haris, Nur Shuhaila Haryani, Nafisah Mansor, Mohd Sukeri Mohd Yusof, Christopher J. Sumby, and Maisara Abdul Kadir. "Investigating the Potential of Flexible and Pre-Organized Tetraamide Ligands to Encapsulate Anions in One-Dimensional Coordination Polymers: Synthesis, Spectroscopic Studies and Crystal Structures." Crystals 11, no. 1 (January 19, 2021): 77. http://dx.doi.org/10.3390/cryst11010077.

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The synthesis of amide-based molecules, possessing pre-organized structures, has received significant attention due to their potential applications as molecular receptors and as components of nanomaterials. In this study, four extended tetraamide ligands incorporating ethylene and propylene spacers, namely 1,2-bis[N,N′-6-(3-pyridylmethylamido)pyridyl-2-carboxyamido]ethane (L1), 1,2-bis[N,N′-6-(4-pyridylmethylamido)pyridyl-2-carboxyamido]ethane (L2), 1,2-bis[N,N′-6-(3-pyridylmethylamido)pyridyl-2-carboxyamido]propane (L3) and 1,2-bis[N,N′-6-(4-pyridylmethylamido)pyridyl-2-carboxyamido]propane (L4), were successfully synthesized. Further, reaction of L2 and L4, incorporating pendant 4-pyridyl donors as the metal coordinating sites, with cadmium salts, produced two close-packed one-dimensional coordination polymers, {[Cd3(L2)4(H2O)10](NO3)6·12H2O·CH3OH}n and {[Cd(SO4)(L4)(H2O)2]·4H2O·CH3OH}n. X-ray crystallography reveals that the flexible tetraamide ligands fold upon themselves in the coordination polymer structure. As a consequence, the anion pocket in {[Cd(SO4)(L4)(H2O)2]·4H2O·CH3OH}n incorporating the ligand with the propylene spacer was blocked from encapsulating charge-balancing anions, which were involved in bridging the di-cadmium units. Interestingly, a strong interaction between the 2,6-pyridine dicarboxamide moiety with the nitrate anions was found in {[Cd3(L2)4(H2O)10](NO3)6·12H2O·CH3OH}n, showing potential for materials made from these ligands to serve as anion receptors.

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10

Wang, Qin, Kuanzhen Tang, Xiaojie Jin, Xiaoguang Huang, Weisheng Liu, Xiaojun Yao, and Yu Tang. "Lanthanide complexes assembled from two flexible amide-type tripodal ligands: terminal groups effect on photoluminescence behavior." Dalton Transactions 41, no. 12 (2012): 3431. http://dx.doi.org/10.1039/c2dt11761d.

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11

Chhetri, Pradhumna Mahat, Ming-Hao Wu, Chou-Ting Hsieh, Xiang-Kai Yang, Chen-Ming Wu, En-Che Yang, Chih-Chieh Wang, and Jhy-Der Chen. "A Pair of CoII Supramolecular Isomers Based on Flexible Bis-Pyridyl-Bis-Amide and Angular Dicarboxylate Ligands." Molecules 25, no. 1 (January 3, 2020): 201. http://dx.doi.org/10.3390/molecules25010201.

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Thermal reactions of cobalt(II) salts with flexible N,N′-bis(pyrid-3-ylmethyl)adipoamide (L) and angular 4,4′-sulfonyldibenzoic acid (H2SDA) in H2O and CH3OH afforded a pair of supramolecular isomers: [Co2(L)(SDA)2], 1, and [Co2(L)(SDA)2]⋅CH3OH⋅H2O, 2. The structure of complex 1 can be simplified as a one-dimensional (1D) looped chain with L ligands penetrating into the middles of squares, forming a new type of self-catenated net with the (42⋅54)(4)2(5)2 topology, whereas complex 2 displays a 2-fold interpenetrated 2D net with the rare (42⋅68⋅8⋅104)(4)2-2,6L1 topology. While both complexes 1 and 2 display antiferromagnetism with strong spin-orbital coupling, the antiferromagnetism of 2 is accompanied by a cross-over behavior and probably a spin canting phenomenon.

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12

Wang, XiuLi, Chuang Xu, HongYan Lin, GuoCheng Liu, Jian Luan, and ZhiHan Chang. "Two novel octamolybdate-based frameworks decorated by flexible bis-pyridyl-bis-amide ligands with different spacer lengths." RSC Advances 3, no. 11 (2013): 3592. http://dx.doi.org/10.1039/c2ra22855f.

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13

Sumby, Christopher J., and Lyall R. Hanton. "Syntheses and studies of flexible amide ligands: a toolkit for studying metallo-supramolecular assemblies for anion binding." Tetrahedron 65, no. 24 (June 2009): 4681–91. http://dx.doi.org/10.1016/j.tet.2009.04.031.

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14

Sun, Junjun, Hongyan Lin, Zhihan Chang, Xiuli Wang, and Guocheng Liu. "Hydrogen Bonding Interactions Directed Various Supramolecular Networks Based on Octamolybdates and Different Flexible Bis-Pyridyl-Bis-Amide Ligands." Journal of Inorganic and Organometallic Polymers and Materials 27, no. 1 (November 28, 2016): 176–85. http://dx.doi.org/10.1007/s10904-016-0460-1.

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15

Li, Feng-Cai, Xi-Li Li, Li-Kun Tan, Jin-Tang Wang, and Wei-Zhong Yao. "Evans–Showell-type polyoxometalate-based metal–organic complexes with novel 3D structures constructed from flexible bis-pyrazine–bis-amide ligands and copper metals: syntheses, structures, and fluorescence and catalytic properties." Dalton Transactions 48, no. 6 (2019): 2160–69. http://dx.doi.org/10.1039/c8dt04698k.

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16

Chen, Chia-Jou, Chia-Ling Chen, Yu-Hsiang Liu, Wei-Te Lee, Ji-Hong Hu, Pradhumna Mahat Chhetri, and Jhy-Der Chen. "Coordination Polymers Constructed from Semi-Rigid N,N′-Bis(3-pyridyl)terephthalamide and Dicarboxylic Acids: Effect of Ligand Isomerism, Flexibility, and Identity." Chemistry 3, no. 1 (December 22, 2020): 1–12. http://dx.doi.org/10.3390/chemistry3010001.

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Reactions of the semi-rigid N,N′-bis(3-pyridyl)terephthalamide (L) with divalent metal salts in the presence of dicarboxylic acids afforded [Cd(L)0.5(1,2-BDC)(H2O)]n (1,2-H2BDC = benzene-1,2-dicarboxylic acid), 1, {[Cd(L)1.5(1,3-BDC)(H2O)]·5H2O}n (1,3-H2BDC = benzene-1,3-dicarboxylic acid), 2a, {[Cd(1,3-BDC)(H2O)3]·2H2O}n, 2b, {[Cd(L)0.5(1,4-BDC)(H2O)2]·H2O}n (1,4-H2BDC = benzene-1,4-dicarboxylic acid), 3, and [Cu(L)0.5(5-tert-IPA)]n (5-tert-IPA = 5-tert-butylbenzene-1,3-dicarboxylic acid), 4, which have been structurally characterized by single crystal X-ray diffraction. Complexes 1 and 3 are two-dimensional (2D) layers with the bey and the hcb topologies, and 2a and 2b are one-dimensional (1D) ladder and zigzag chain, respectively, while 4 shows a 3-fold interpenetrated three-dimensional (3D) net with the cds topology. The structures of these coordination polymers containing the semi-rigid L ligands are subject to the donor atom positions and the identity of the dicarboxylate ligands, which are in marked contrast to those obtained from the flexible bis-pyridyl-bis-amide ligands that form self-catenated nets. The luminescence of 1 and 3 and thermal properties of complexes 1, 3, and 4 are also discussed.

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17

Wölper, Christoph, Alejandra Rodríguez-Gimeno, Katherine Chulvi Iborra, Helene Kuhn, Anne Kristin Lüttig, Sabrina Moll, Christin Most, et al. "Polysulfonylamine, CLXXXVII [1]. Strukturvielfalt in (Acetonitril)silber(I)-di(arensulfonyl)amiden: Zwei Molek¨ulkristalle mit Z'= 1, ein Ionenkristall mit Z' = 2 und zwei auf Halogenbr¨ucken C–Br···O=S beruhende molekulare Polymorphe mit Z' = 1 beziehungsweise Z' = 2 in der gleichen Raumgruppe / Polysulfonylamines, CLXXXVII. Structural Diversity in (Acetonitrile)silver(I) Di(arenesulfonyl)- amides: Two Molecular Z' = 1 Crystals, an Ionic Z' = 2 Crystal, and Two Molecular Polymorphs Based upon C–Br· · ·O=S Halogen Bonds and Featuring Z' = 1 or Z' = 2 in the Same Space Group." Zeitschrift für Naturforschung B 64, no. 8 (August 1, 2009): 952–68. http://dx.doi.org/10.1515/znb-2009-0811.

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Crystallization of silver di(4-methylbenzenesulfonyl)amide [Ag(MA)], silver di(4-nitrobenzenesulfonyl) amide [Ag(NA)], silver di(4-bromobenzenesulfonyl)amide [Ag(BA)] or silver di(4-fluorobenzenesulfonyl) amide [Ag(FA)] from acetonitrile solutions under slightly different conditions afforded single crystals of the following complexes, which were structurally authenticated by X-ray diffraction at low temperatures: (MeCN)Ag(MA) (1, triclinic, space group P1, Z’ = 1), (MeCN)2Ag(NA) (2, monoclinic, P21/c, Z’ = 1), (MeCN)2Ag(BA) (3, monoclinic, P21/c, Z’ = 1), (MeCN)2Ag(BA) (4, monoclinic, P21/c, Z’ = 2), and [(MeCN)3Ag][Ag(FA)2]・MeCN (5, triclinic , Z’ = 1). In each structure, the inner coordination sphere of silver is formed by the ligand nitrogen atoms, leading to a linear NAgN core for the molecular complex 1 and the complex anion of 5, or to a trigonal planar AgN3 core for the molecular complex 2, the molecular polymorphs 3 and 4, and the complex cation of 5. The flexible di(arenesulfonyl)amide ligands adopt extended pseudo-C2 symmetric conformations in 1, 2 and 5, but folded pseudo-mirror symmetric conformations in 3 and 4. The molecules of 1 are associated into inversion-symmetric dimers via a short Ag・・・O contact; the dimers form stacks by translation along the a axis, causing the silver ions to segregate in zigzag chains. The arrangement of the molecules in 2 is controlled mainly by a centered C-H・・・Ph hydrogen bond, a dipolar nitro-nitro and a dipolar nitro-sulfonyl interaction, giving rise to layers oriented parallel to the bc plane. The packing motifs of polymorphs 3 and 4 are very similar. Both forms consist of layers in which the molecules act as 4-connecting nodes in a network based upon C-Br・・・O=S halogen bonds. In the Z’ = 1 structure of 3, the layers are generated by 2l screw axes and display one short and one long halogen bond, whereas in the Z’ = 2 structure of 4, the layers are realized by glide planes and are based on four independent halogen bonds that are all reasonably short. The packing of 5 exhibits alternating layers comprised of complex anions or of complex cations and acetonitrile solvent molecules, respectively. This Z’ = 2 structure may be viewed as a kinetic polymorph of a more symmetric Z’ = 1 crystal

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18

Lin, HongYan, Jing Zhao, Yuan Tian, Xiang Wang, and GuoCheng Liu. "Assembly, characterization and photocatalytic properties of four copper(II) coordination complexes functionalized by three flexible bis(pyridyl)-bis(amide) ligands." Transition Metal Chemistry 41, no. 7 (July 20, 2016): 807–17. http://dx.doi.org/10.1007/s11243-016-0082-z.

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19

Pan, Xiang, Xiang Wang, Xiuli Wang, Guocheng Liu, Hongyan Lin, and Yan Li. "Four octamolybdate-based complexes based on flexible bis-imidazole-bis-amide ligands with different lengths: Structure, electrochemical and photocatalytic properties." Inorganica Chimica Acta 495 (September 2019): 118998. http://dx.doi.org/10.1016/j.ica.2019.118998.

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20

Wang, Xiu-Li, Jian Luan, Qi-Lin Lu, Hong-Yan Lin, Chuang Xu, and Guo-Cheng Liu. "Four new metal–organic complexes by tuning the spacer length of flexible bis-pyridyl–bis-amide ligands: Assembly, structures and properties." Journal of Organometallic Chemistry 740 (September 2013): 17–25. http://dx.doi.org/10.1016/j.jorganchem.2013.04.040.

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21

Wang, Xiuli, Jian Luan, Hongyan Lin, Qilin Lu, Chuang Xu, and Guocheng Liu. "Effect of flexible bis-pyridyl-bis-amide ligands and dicarboxylates on the assembly and properties of multifunctional Cu(ii) metal–organic coordination polymers." Dalton Transactions 42, no. 23 (2013): 8375. http://dx.doi.org/10.1039/c3dt50202c.

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22

Wang, Xiu-Li, Junjun Sun, Hongyan Lin, Zhihan Chang, Xue Bai, and Xiang Wang. "Assembly, structures, electrocatalytic and photocatalytic properties of a series of Anderson-type polyoxometalate-based metal–organic complexes based on flexible pyridyl-amide ligands." Polyhedron 124 (March 2017): 30–40. http://dx.doi.org/10.1016/j.poly.2016.12.040.

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23

Wang, Xiu-Li, Zhi-Han Chang, Hong-Yan Lin, Guo-Cheng Liu, Chuang Xu, Jian Luan, Ai-Xiang Tian, and Ju-Wen Zhang. "Syntheses, structures and properties of three Keggin-based metal–organic complexes derived from flexible bis-pyridyl-bis-amide and rigid phenanthroline mixed ligands." Inorganica Chimica Acta 413 (March 2014): 16–22. http://dx.doi.org/10.1016/j.ica.2013.12.035.

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24

Lu, Qi-Lin, Jian Luan, Xiu-Li Wang, Hong-Yan Lin, Mao Le, and Guo-Cheng Liu. "A series of two-dimensional coordination polymer crystal materials based on two flexible bis-pyridyl-bis-amide ligands with fluorescent sensing activities and photocatalytic properties." Polyhedron 83 (November 2014): 108–15. http://dx.doi.org/10.1016/j.poly.2014.05.024.

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25

LIN, HONGYAN, HUIZHE LU, MAO LE, JIAN LUAN, XIULI WANG, and GUOCHENG LIU. "Three 2 D copper(II)/cadmium(II) coordination polymers based on semi-rigid/flexible bis-pyridyl-bis-amide ligands and 5-aminoisophthalate: Syntheses, structures and properties." Journal of Chemical Sciences 127, no. 7 (July 2015): 1275–85. http://dx.doi.org/10.1007/s12039-015-0882-2.

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26

Elkamhawy, Ahmed, Jiyu Woo, Hossam Nada, Andrea Angeli, Tarek M. Bedair, Claudiu T. Supuran, and Kyeong Lee. "Identification of Novel and Potent Indole-Based Benzenesulfonamides as Selective Human Carbonic Anhydrase II Inhibitors: Design, Synthesis, In Vitro, and In Silico Studies." International Journal of Molecular Sciences 23, no. 5 (February 25, 2022): 2540. http://dx.doi.org/10.3390/ijms23052540.

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In recent decades, human carbonic anhydrase inhibitors (hCAIs) have emerged as an important therapeutic class with various applications including antiglaucoma, anticonvulsants, and anticancer agents. Herein, a novel series of indole-based benzenesulfonamides were designed, synthesized, and biologically evaluated as potential hCAIs. A regioisomerism of the sulfonamide moiety was carried out to afford a total of fifteen indole-based benzenesulfonamides possessing different amide linkers that enable the ligands to be flexible and develop potential H-bond interaction(s) with the target protein. The activity of the synthesized compounds was evaluated against four hCA isoforms (I, II, IX and, XII). Compounds 2b, 2c, 2d, 2f, 2h and 2o exhibited potent and selective profiles over the hCA II isoform with Ki values of 7.3, 9.0, 7.1, 16.0, 8.6 and 7.5 nM, respectively. Among all, compound 2a demonstrated the most potent inhibition against the hCA II isoform with an inhibitory constant (Ki) of 5.9 nM, with 13-, 34-, and 9-fold selectivity for hCA II over I, IX and XII isoforms, respectively. Structure–activity relationship data attained for various substitutions were rationalized. Furthermore, a molecular docking study gave insights into both inhibitory activity and selectivity of the target compounds. Accordingly, this report presents a successful scaffold hoping approach that reveals compound 2a as a highly potent and selective indole-based hCA II inhibitor worthy of further investigation.

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27

Lin, Hongyan, Jian Luan, Xiuli Wang, Guocheng Liu, Aixiang Tian, and Juwen Zhang. "Assembly and properties of four new metal–organic coordination polymers with flexible bis-pyridyl-bis-amide ligands: effect of aromatic dicarboxylates and central metal ions on the structures." Journal of Coordination Chemistry 68, no. 1 (November 26, 2014): 71–87. http://dx.doi.org/10.1080/00958972.2014.983492.

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28

Wang, Xiu-Li, Jian Luan, Fang-Fang Sui, Hong-Yan Lin, Guo-Cheng Liu, and Chuang Xu. "Structural Diversities and Fluorescent and Photocatalytic Properties of a Series of CuII Coordination Polymers Constructed from Flexible Bis-pyridyl-bis-amide Ligands with Different Spacer Lengths and Different Aromatic Carboxylates." Crystal Growth & Design 13, no. 8 (June 27, 2013): 3561–76. http://dx.doi.org/10.1021/cg400538c.

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29

Gómez-Suárez, Adrián, David J. Nelson, David G. Thompson, David B. Cordes, Duncan Graham, Alexandra M. Z. Slawin, and Steven P. Nolan. "Synthesis, characterization and luminescence studies of gold(I)–NHC amide complexes." Beilstein Journal of Organic Chemistry 9 (October 28, 2013): 2216–23. http://dx.doi.org/10.3762/bjoc.9.260.

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A flexible, efficient and straightforward methodology for the synthesis of N-heterocyclic carbene gold(I)–amide complexes is reported. Reaction of the versatile building block [Au(OH)(IPr)] (1) (IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene) with a series of commercially available (hetero)aromatic amines leads to the synthesis of several [Au(NRR’)(IPr)] complexes in good yields and with water as the sole byproduct. Interestingly, these complexes present luminescence properties. UV–vis and fluorescence measurements have allowed the identification of their excitation and emission wavelengths (λmax). These studies revealed that by selecting the appropriate amine ligand the emission can be easily tuned to achieve a variety of colors, from violet to green.

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30

Pan, Yung-Tin, Cartney E. Smith, Kam Sang Kwok, Jinrong Chen, Hyunjoon Kong, and Hong Yang. "Functionalized ultrathin palladium nanosheets as patches for HepG2 cancer cells." Chemical Communications 51, no. 75 (2015): 14171–74. http://dx.doi.org/10.1039/c5cc04727g.

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31

Basu, Arghya, Romen Chutia, and Gopal Das. "Dual modes of binding on the hexafluorosilicate anion by a C3v symmetric flexible tripodal amide ligand in solid state." CrystEngComm 16, no. 22 (2014): 4886–91. http://dx.doi.org/10.1039/c4ce00529e.

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A para-nitrophenyl functionalized C_3v symmetric flexible tripodal amide ligand, L, shows remarkable solvent dependent dual binding behaviour towards the octahedral hexafluorosilicate anion in solid state.

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32

Emerson, Adrian J., Gregory P. Knowles, Alan L. Chaffee, Stuart R. Batten, and David R. Turner. "p-Xylylenediamine derived ligands as flexible connectors in the design of porous coordination polymers." CrystEngComm 21, no. 19 (2019): 3074–85. http://dx.doi.org/10.1039/c9ce00371a.

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33

Emerson, Adrian J., Chris S. Hawes, Gregory P. Knowles, Alan L. Chaffee, Stuart R. Batten, and David R. Turner. "Coordination polymers from a flexible alkyldiamine-derived ligand." CrystEngComm 19, no. 34 (2017): 5137–45. http://dx.doi.org/10.1039/c7ce01133d.

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34

Evans, Lloyd T. J., Joy H. Farnaby, Martyn P. Coles, F. Geoffrey N. Cloke, and Peter B. Hitchcock. "Group 4 metal compounds incorporating the amide ligand, [N(SiMe2{C6H4-2-OMe})2]−." Dalton Transactions 44, no. 19 (2015): 8950–58. http://dx.doi.org/10.1039/c5dt00684h.

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35

La Monica, Laura, and Donato Monti. "Flexible dizinc diporphyrin systems as selective receptors for ditopic amine ligands." Journal of Porphyrins and Phthalocyanines 06, no. 01 (January 2002): 58–65. http://dx.doi.org/10.1142/s1088424602000099.

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Zinc (II) diporphyrin systems, characterised by the presence of flexible oligooxaethylene spacers of different lengths, have been synthesised and the binding properties toward a series of aliphatic and aromatic diamine derivatives characterised by different structural and coordination properties, investigated. The results obtained, compared to that for a rigid diporphyrin cleft, point out that the observed degree of selectivity is dependent both on the length of the spacer and on the nature of the nitrogen ligands.

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Sprenger, Janina, Bo Svensson, Jenny Hålander, Jannette Carey, Lo Persson, and Salam Al-Karadaghi. "Three-dimensional structures ofPlasmodium falciparumspermidine synthase with bound inhibitors suggest new strategies for drug design." Acta Crystallographica Section D Biological Crystallography 71, no. 3 (February 26, 2015): 484–93. http://dx.doi.org/10.1107/s1399004714027011.

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The enzymes of the polyamine-biosynthesis pathway have been proposed to be promising drug targets in the treatment of malaria. Spermidine synthase (SpdS; putrescine aminopropyltransferase) catalyzes the transfer of the aminopropyl moiety from decarboxylatedS-adenosylmethionine to putrescine, leading to the formation of spermidine and 5′-methylthioadenosine (MTA). In this work, X-ray crystallography was used to examine ligand complexes of SpdS from the malaria parasitePlasmodium falciparum(PfSpdS). Five crystal structures were determined ofPfSpdS in complex with MTA and the substrate putrescine, with MTA and spermidine, which was obtained as a result of the enzymatic reaction taking place within the crystals, with dcAdoMet and the inhibitor 4-methylaniline, with MTA and 4-aminomethylaniline, and with a compound predicted in earlierin silicoscreening to bind to the active site of the enzyme, benzimidazol-(2-yl)pentan-1-amine (BIPA). In contrast to the other inhibitors tested, the complex with BIPA was obtained without any ligand bound to the dcAdoMet-binding site of the enzyme. The complexes with the aniline compounds and BIPA revealed a new mode of ligand binding toPfSpdS. The observed binding mode of the ligands, and the interplay between the two substrate-binding sites and the flexible gatekeeper loop, can be used in the design of new approaches in the search for new inhibitors of SpdS.

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Dordahan, Fatemeh, and Frank Schaper. "Lactide polymerization using a sterically encumbered, flexible zinc complex." Canadian Journal of Chemistry 100, no. 4 (April 2022): 296–302. http://dx.doi.org/10.1139/cjc-2021-0239.

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4-(tert-Butyl)-2-trityl-6-(di-(2-picolyl)amine)phenol, LH, was prepared from paraformaldehyde, 4-(tert-butyl)-2-tritylphenol, and di-(2-picolyl)amine. Reaction with Zn(N(SiMe3)2)2 gave LZnN(SiMe3)2. The complex was shown by X-ray diffraction study, variable temperature NMR, and DFT calculations to coordinate only one pyridine ligand, which allows for fast and facile complex isomerisation. LZnN(SiMe3)2 was active in rac-lactide polymerization, but in contrast to previous complexes of this type, it did not show any evidence for isotactic monomer enchainment via a catalytic-site mediated chain-end control mechanism. Addition of alcohol led to increased activity, but the complex was unstable in the presence of free alcohol.

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Pokorski, Jonathan K., and Daniel H. Appella. "Combinatorial Synthesis, Screening, and Binding Studies of Highly Functionalized Polyamino-amido Oligomers for Binding to Folded RNA." Journal of Nucleic Acids 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/971581.

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Folded RNA molecules have recently emerged as critical regulatory elements in biological pathways, serving not just as carriers of genetic information but also as key components in enzymatic assemblies. In particular, the transactivation response element (TAR) of the HIV genome regulates transcriptional elongation by interacting specifically with the Tat protein, initiating the recruitment of the elongation complex. Preventing this interaction from occurringin vivohalts HIV replication, thus making RNA-binding molecules an intriguing pharmaceutical target. Usingα-amino acids as starting materials, we have designed and synthesized a new class of polyamino-amido oligomers, called PAAs, specifically for binding to folded RNA structures. The PAA monomers were readily incorporated into a 125-member combinatorial library of PAA trimers. In order to rapidly assess RNA binding, a quantum dot-based fluorescent screen was developed to visualize RNA binding on-resin. The binding affinities of hits were quantified using a terbium footprinting assay, allowing us to identify a ligand (SFF) with low micromolar affinity(kd=14 μM)for TAR RNA. The work presented herein represents the development of a flexible scaffold that can be easily synthesized, screened, and subsequently modified to provide ligands specific for binding to folded RNAs.

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Wrzesińska, Angelika, Aleksandra Wypych-Puszkarz, Izabela Bobowska, and Jacek Ulański. "Effects of Counter Anions on AC and DC Electrical Conductivity in Poly(Dimethylsiloxane) Crosslinked by Metal-Ligand Coordination." Polymers 13, no. 6 (March 20, 2021): 956. http://dx.doi.org/10.3390/polym13060956.

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There is an urgent need for the development of elastic dielectric materials for flexible organic field effect transistors (OFETs). In this work, detailed analysis of the AC and DC electrical conductivity of a series of flexible poly(dimethylsiloxane) (PDMS) polymers crosslinked by metal-ligand coordination in comparison to neat PDMS was performed for the first time by means of broadband dielectric spectroscopy. The ligand was 2,2-bipyridine-4,4-dicarboxylic amide, and Ni2+, Mn2+, and Zn2+ were introduced for Cl−, Br−, and I− salts. Introduction of metal salt and creation of coordination bonds resulted in higher permittivity values increasing in an order: neat PDMS < Ni2+ < Mn2+ < Zn2+; accompanied by conductivity values of the materials increasing in an order: neat PDMS < Cl− < I− < Br−. Conductivity relaxation time plot as a function of temperature, showed Vogel-Fulcher–Tammann dependance for the Br− salts and Arrhenius type for the Cl− and I− salts. Performed study revealed that double-edged challenge can be obtained, i.e., dielectric materials with elevated value of dielectric permittivity without deterioration too much the non-conductive nature of the polymer. This opens up new perspectives for the production of flexible dielectrics suitable for gate insulators in OFETs. Among the synthesized organometallic materials, those with chlorides salts are the most promising for such applications.

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Oloyede, Hammed Olawale, Joseph Anthony Orighomisan Woods, Helmar Görls, Winfried Plass, and Abiodun Omokehinde Eseola. "Flexible, N-sulfonyl-substituted aliphatic amine ligands in palladium-catalyzed Suzuki–Miyaura C C coupling: Influence of substituents bulkiness and co-ligand size." Polyhedron 159 (February 2019): 182–91. http://dx.doi.org/10.1016/j.poly.2018.11.044.

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41

Stoscup, Julie A., Richard J. Staples, and Shannon M. Biros. "Crystal structure of a samarium(III) nitrate chain cross-linked by a bis-carbamoylmethylphosphine oxide ligand." Acta Crystallographica Section E Structure Reports Online 70, no. 10 (September 13, 2014): 188–91. http://dx.doi.org/10.1107/s1600536814020078.

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In the title compound poly[aquabis(μ-nitrato-κ4O,O′:O,O′′)tetrakis(nitrato-κ2O,O′){μ4-tetraethyl [(ethane-1,2-diyl)bis(azanediyl)bis(2-oxoethane-2,1-diyl)]diphosphonate-κ2O,O′}disamarium(III)], [Sm2(NO3)6(C14H30N2O8P2)(H2O)]n, a 12-coordinate SmIIIand a nine-coordinate SmIIIcation are alternately linkedviashared bis-bidentate nitrate anions into a corrugated chain extending parallel to theaaxis. The nine-coordinate SmIIIatom of this chain is also chelated by a bidentate, yet flexible, carbamoylmethylphoshine oxide (CMPO) ligand and bears one water molecule. This water molecule is hydrogen bonded to nitrate groups bonded to the 12-coordinate SmIIIcation. The CMPO ligand, which lies about an inversion center, links neighboring chains along thecaxis, forming sheets parallel to theacplane. Hydrogen bonds between the amide NH group and metal-bound nitrate anions are also present in these sheets. The sheets are packed along thebaxis through only van der Waals interactions.

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Liu, Shuang, Ernest Wong, Veranja Karunaratne, Steven J. Rettig, and Chris Orvig. "Highly flexible chelating ligands for Group 13 metals: design and synthesis of hexadentate (N3O3) tripodal amine phenol ligand complexes of aluminum, gallium, and indium." Inorganic Chemistry 32, no. 9 (April 1993): 1756–65. http://dx.doi.org/10.1021/ic00061a036.

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43

Gennari, Cesare, Chiara Monti, and Umberto Piarulli. "Rhodium-catalyzed asymmetric reactions with a dynamic library of chiral tropos phosphorus ligands." Pure and Applied Chemistry 78, no. 2 (January 1, 2006): 303–10. http://dx.doi.org/10.1351/pac200678020303.

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Nineteen chiral tropos phosphorus ligands, based on a flexible (tropos) biphenol unit and a chiral P-bound alcohol (11 phosphites) or secondary amine (8 phosphoramidites), were screened, individually and as a combination of two, in various Rh-catalyzed asymmetric reactions. In the Rh-catalyzed asymmetric conjugate addition of phenylboronic acid to cyclic enones, enantiomeric excesses (ee's) up to 95 % were obtained with a 1:1 mixture of a phosphite [derived from (1R,2S)-2-(1-methyl-1-phenylethyl)cyclohexanol] and a phosphoramidite [derived from (S,S)-2,5-diphenylpyrrolidine]. In the mixed Rh precatalyst, which was characterized via 31P-NMR, the biphenol-derived phosphite is free to rotate (tropos) while the biphenol-derived phosphoramidite shows a temperature-dependent tropos/atropos behavior (coalescence temperature = 310 K). The ligands were also screened in the hydrogenation of dehydro-α-amino acids and dehydro-β-amino acids. Ee's up to 98% were obtained for the dehydro-α-amino acids, using the combination of a phosphite [derived from (1R,2S)-2-phenyl-1-cyclohexanol] and a phosphoramidite [derived from (S,S)-bis(α-methylbenzyl)amine]. The reaction was optimized by lowering the phosphite/phosphoramidite ratio to 0.25:1.75 with a resulting improvement of the product ee.

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Balestri, Davide, Davide Costa, Alessia Bacchi, Lucia Carlucci, and Paolo Pelagatti. "Linker dependent dimensionality in Zn(II)-coordination polymers containing a flexible bis-pyridyl-bis-amide ligand." Polyhedron 153 (October 2018): 278–85. http://dx.doi.org/10.1016/j.poly.2018.07.025.

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45

Wang, Xiu-Li, Chuang Xu, Hong-Yan Lin, Jian Luan, Guo-Cheng Liu, Ai-Xiang Tian, and Ju-Wen Zhang. "A new POM-templated metal–organic complex based on the flexible bis-pyridyl-bis-amide ligand." Transition Metal Chemistry 37, no. 8 (October 11, 2012): 751–56. http://dx.doi.org/10.1007/s11243-012-9647-7.

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46

Wang, Xiuli, Xiang Pan, Xiang Wang, Guocheng Liu, Hongyan Lin, and Shan Zhang. "Polyoxometalate-based complexes with a flexible bis-imidazole-bis-amide ligand: structures, electrochemical and photocatalytic properties." Transition Metal Chemistry 44, no. 3 (October 30, 2018): 207–17. http://dx.doi.org/10.1007/s11243-018-0284-7.

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47

Byun, Jonghoe. "Recent Progress and Opportunities for Nucleic Acid Aptamers." Life 11, no. 3 (February 28, 2021): 193. http://dx.doi.org/10.3390/life11030193.

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Coined three decades ago, the term aptamer and directed evolution have now reached their maturity. The concept that nucleic acid could modulate the activity of target protein as ligand emerged from basic science studies of viruses. Aptamers are short nucleic acid sequences capable of specific, high-affinity molecular binding, which allow for therapeutic and diagnostic applications. Compared to traditional antibodies, aptamers have several advantages, including small size, flexible structure, good biocompatibility, and low immunogenicity. In vitro selection method is used to isolate aptamers that are specific for a desired target from a randomized oligonucleotide library. The first aptamer drug, Macugen, was approved by FDA in 2004, which was accompanied by many studies and clinical investigations on various targets and diseases. Despite much promise, most aptamers have failed to meet the requisite safety and efficacy standards in human clinical trials. Amid these setbacks, the emergence of novel technologies and recent advances in aptamer and systematic evolution of ligands by exponential enrichment (SELEX) design are fueling hope in this field. The unique properties of aptamer are gaining renewed interest in an era of COVID-19. The binding performance of an aptamer and reproducibility are still the key issues in tackling current hurdles in clinical translation. A thorough analysis of the aptamer binding under varying conditions and the conformational dynamics is warranted. Here, the challenges and opportunities of aptamers are reviewed with recent progress.

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Wang, Xiu-Li, Na Han, Hong-Yan Lin, Chuang Xu, Jian Luan, and Guo-Cheng Liu. "A Novel 3D Polypseudo-rotaxane Metal-organic Framework Based on a Flexible Bis-pyridyl-bis-amide Ligand." Bulletin of the Korean Chemical Society 33, no. 11 (November 20, 2012): 3793–96. http://dx.doi.org/10.5012/bkcs.2012.33.11.3793.

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Karmakar, Anirban, Clive L. Oliver, Somnath Roy, and Lars Öhrström. "The synthesis, structure, topology and catalytic application of a novel cubane-based copper(ii) metal–organic framework derived from a flexible amido tripodal acid." Dalton Transactions 44, no. 22 (2015): 10156–65. http://dx.doi.org/10.1039/c4dt03087g.

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A novel chiral metal–organic framework, [Cu₄(HL)₂(H₂O)₄(MeO)₄]_n (1), has been successfully synthesized from a tripodal flexible ligand (2S,2′S,2′′S)-2,2′,2′′-(benzenetricarbonyltris(azanediyl))tripropanoic acid.

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Wang, Xiuli, Chuang Xu, Hongyan Lin, Guocheng Liu, Jian Luan, Aixiang Tian, and Juwen Zhang. "A new Wells-Dawson polyoxometalate-based metal-organic hybrid decorated by the flexible bis-pyridyl-bis-amide ligand." Inorganic Chemistry Communications 24 (October 2012): 43–46. http://dx.doi.org/10.1016/j.inoche.2012.07.016.

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