Relevant bibliographies by topics / Flavonoids – Synthesis

Academic literature on the topic 'Flavonoids – Synthesis'

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Published: 4 June 2021
Last updated: 10 February 2022

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Journal articles on the topic "Flavonoids – Synthesis"

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Li, Chengshuai, Lijing Zhang, Decao Niu, Shuzhen Nan, Xiumei Miao, Xiaowei Hu, and Hua Fu. "Investigation of flavonoid expression and metabolite content patterns during seed formation of Artemisia sphaerocephala Krasch." Seed Science Research 31, no. 2 (June 2021): 136–48. http://dx.doi.org/10.1017/s096025852100012x.

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AbstractFlavonoids are a group of phenolic secondary metabolites in plants that have important physiological, ecological and economic value. In this study, using the desert plant Artemisia sphaerocephala Krasch. as the sample material, the content and components of the total flavonoids in its seeds at seven different developmental stages were determined. In addition, the genes involved in flavonoid metabolism were identified by full-length transcriptome sequencing (third-generation sequencing technology based on PacBio RS II). Their expression levels were analysed by RNA-seq short reading sequencing, to reveal the patterns and regulation mechanisms of flavonoid accumulation during seed development. The key results were as follows: the content of total flavonoids in mature seeds was 15.05 mg g−1, including five subclasses: flavonols, chalcones, flavones, flavanones and proanthocyanidins, among which flavonols accounted for 45.78%. The period of rapid accumulation of flavonoids was 40–70 d following anthesis. The high expression of phenylalanine ammonia-lyase (PAL), 4-coumarate-CoA ligase (4CL) and UDP-glucose:flavonoids 3-o-glucosyltransferase (UF3GT) promoted the accumulation of total flavonoids, while the high expression of flavonoids 3′-hydroxylase (F3′H) and flavonols synthase (FLS) made flavanols the main component. Transcription factors such as the MYB-bHLH-WDR (MBW) complex and Selenium-binding protein (SBP) directly regulated the structural genes of flavonoid metabolism, while C2H2-type zinc finger (C2H2), Zinc-finger transcription factor (GATA), Dehydration-responsive element binding (DREB), Global Transcription factor Group E protein (GTE), Trihelix DNA-binding factors (Trihelix) and Phytochrome-interacting factor (PIF) indirectly promoted the synthesis of flavonoids through hormones such as brassinoidsteroids (BRs) and abscisic acid (ABA). These results provided valuable resources for the application of related genes in genetics and breeding.
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Fardoun, Manal Muin, Dina Maaliki, Nabil Halabi, Rabah Iratni, Alessandra Bitto, Elias Baydoun, and Ali H. Eid. "Flavonoids in adipose tissue inflammation and atherosclerosis: one arrow, two targets." Clinical Science 134, no. 12 (June 2020): 1403–32. http://dx.doi.org/10.1042/cs20200356.

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Abstract Flavonoids are polyphenolic compounds naturally occurring in fruits and vegetables, in addition to beverages such as tea and coffee. Flavonoids are emerging as potent therapeutic agents for cardiovascular as well as metabolic diseases. Several studies corroborated an inverse relationship between flavonoid consumption and cardiovascular disease (CVD) or adipose tissue inflammation (ATI). Flavonoids exert their anti-atherogenic effects by increasing nitric oxide (NO), reducing reactive oxygen species (ROS), and decreasing pro-inflammatory cytokines. In addition, flavonoids alleviate ATI by decreasing triglyceride and cholesterol levels, as well as by attenuating inflammatory mediators. Furthermore, flavonoids inhibit synthesis of fatty acids and promote their oxidation. In this review, we discuss the effect of the main classes of flavonoids, namely flavones, flavonols, flavanols, flavanones, anthocyanins, and isoflavones, on atherosclerosis and ATI. In addition, we dissect the underlying molecular and cellular mechanisms of action for these flavonoids. We conclude by supporting the potential benefit for flavonoids in the management or treatment of CVD; yet, we call for more robust clinical studies for safety and pharmacokinetic values.
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Yang, Yun, Mengjiao Chen, Yaxin Liu, Huanhuan Ding, Hongyan Du, Zhiqiang Sun, and Jingle Zhu. "Metabolome and Transcriptome Analyses Reveal Different Flavonoid Biosynthesis and Chlorophyll Metabolism Profiles between Red Leaf and Green Leaf of Eucommia ulmoides." Forests 12, no. 9 (September 16, 2021): 1260. http://dx.doi.org/10.3390/f12091260.

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Flavonoids are natural antioxidants in plants that affect the color of plant tissues. Flavonoids can be divided into eight subgroups, including flavonols, anthocyanins, and proanthocyanidins. The mechanisms of flavonoid synthesis in model plants have been widely studied. However, there are a limited number of reports on the synthesis of flavonoids in the red leaf varieties of woody plants. In this study, we combined morphological observation, pigment content determination, metabolomics, and transcriptomics to investigate the metabolites and gene regulation present in the red and green leaves of Eucommia ulmoides Oliv. The results showed that the red leaves have a lower chlorophyll content and a higher anthocyanin content. Metabonomic analysis identified that the relative content of most flavonoids is up-regulated in red leaves based on UPLC-ESI-MS/MS, which included the apigenin class, quercetin class, kaempferol class, and procyanidins. Transcriptome data suggested that the differentially up-regulated genes are enriched in flavonoid and anthocyanin synthesis pathways, ABC transport, and GST pathways. The integrative analysis of the transcriptome and metabolome showed that the up-regulation of flavonoid metabolism and a high expression of chlorophyll degradation with the down-regulation of chlorophyll biosynthesis genes are detected in E. ulmoides red leaves compared with green leaves. In addition, the co-expression networks implied that cyanidin 3-5-O-diglucoside, EuDR5, EuPAL2, EuDFR11, Eu3MaT1, and EuF3′H are likely associated with the red leaf coloration of E. ulmoides. In summary, this research provided a reference for studying the mechanism of red leaf coloration in woody plants and the use of E. ulmoides red leaves as feedstock for bioactive products.
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Ma, Dawei, Hao Tang, Michael Reichelt, Eerik-Mikael Piirtola, Juha-Pekka Salminen, Jonathan Gershenzon, and C. Peter Constabel. "Poplar MYB117 promotes anthocyanin synthesis and enhances flavonoid B-ring hydroxylation by up-regulating the flavonoid 3′,5′-hydroxylase gene." Journal of Experimental Botany 72, no. 10 (March 12, 2021): 3864–80. http://dx.doi.org/10.1093/jxb/erab116.

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Abstract Flavonoids, such as anthocyanins, proanthocyanidins, and flavonols, are widespread plant secondary metabolites and important for plant adaptation to diverse abiotic and biotic stresses. Flavonoids can be variously hydroxylated and decorated; their biological activity is partly dependent on the degree of hydroxylation of the B-ring. Flavonoid biosynthesis is regulated by MYB transcription factors, which have been identified and characterized in a diversity of plants. Here we characterize a new MYB activator, MYB117, in hybrid poplar (Populus tremula×tremuloides). When overexpressed in transgenic poplar plants, MYB117 enhanced anthocyanin accumulation in all tissues. Transcriptome analysis of MYB117-overexpressing poplars confirmed the up-regulation of flavonoid and anthocyanin biosynthesis genes, as well as two flavonoid 3′,5′-hydroxylase (F3′5′H) genes. We also identified up-regulated cytochrome b5 genes, required for full activity of F3′5′H . Phytochemical analysis demonstrated a corresponding increase in B-ring hydroxylation of anthocyanins, proanthocyanidins, and flavonols in these transgenics. Similarly, overexpression of F3′5′H1 directly in hybrid poplar also resulted in increased B-ring hydroxylation, but without affecting overall flavonoid content. However, the overexpression of the cytochrome b5 gene in F3′5′H1-overexpressing plants did not further increase B-ring hydroxylation. Our data indicate that MYB117 regulates the biosynthesis of anthocyanins in poplar, but also enhances B-ring hydroxylation by up-regulating F3′5′H1.
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Trifunschi, Svetlana, and Melania Florina Munteanu. "Synthesis, Characterization and Antioxidant Activity of Cooper-Quercetin Complex and Iron-Quercetin Complex." Revista de Chimie 69, no. 10 (November 15, 2018): 2621–24. http://dx.doi.org/10.37358/rc.18.10.6593.

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Complexes of cooper (II) and iron (II) with flavonoid quercetin have been synthesized. The structure of compounds has been confirmed by means of UV-Vis and FTIR spectroscopic techniques. The antioxidant activity of the flavonoid complexes has been evaluated by using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging method. These complexes of flavonoids are much more effective free radical scavengers than the free flavonoids, an aspect which recommends them for further studies on possible therapeutic applications.
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Wang, Tao, Qingjun Zou, Qiaosheng Guo, Feng Yang, Liwei Wu, and Wenyan Zhang. "Widely Targeted Metabolomics Analysis Reveals the Effect of Flooding Stress on the Synthesis of Flavonoids in Chrysanthemum morifolium." Molecules 24, no. 20 (October 14, 2019): 3695. http://dx.doi.org/10.3390/molecules24203695.

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Chrysanthemum morifolium. cv “Hangju” is an important medicinal material with many functions in China. Flavonoids as the main secondary metabolites are a major class of medicinal components in “Hangju” and its composition and content can change significantly after flooding. This study mimicked the flooding stress of “Hangju” during flower bud differentiation and detected its metabolites in different growth stages. From widely targeted metabolomics data, 661 metabolites were detected, of which 46 differential metabolites exist simultaneously in the different growth stages of “Hangju”. The top three types of the 46 differential metabolites were flavone C-glycosides, flavonol and flavone. Our results demonstrated that the accumulation of flavonoids in different growth stages of “Hangju” was different; however, quercetin, eriodictyol and most of the flavone C-glycosides were significantly enhanced in the two stages after flooding stress. The expression of key enzyme genes in the flavonoid synthesis pathway were determined using RT-qPCR, which verified the consistency of the expression levels of CHI, F3H, DFR and ANS with the content of the corresponding flavonoids. A regulatory network of flavonoid biosynthesis was established to illustrate that flooding stress can change the accumulation of flavonoids by affecting the expression of the corresponding key enzymes in the flavonoid synthesis pathway.
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Khater, Mai, Divyashree Ravishankar, Francesca Greco, and Helen MI Osborn. "Metal complexes of flavonoids: their synthesis, characterization and enhanced antioxidant and anticancer activities." Future Medicinal Chemistry 11, no. 21 (November 2019): 2845–67. http://dx.doi.org/10.4155/fmc-2019-0237.

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Flavonoids are polyphenolic compounds of natural origin. They are extensively studied within drug discovery programs due to their wide ranging biological activities such as antimicrobial, antioxidant, antitumor, neuroprotective and cardioprotective properties. The ability of flavonoids to coordinate with metal atoms has provided new leads for drug discovery programs, with better pharmacological activities and clinical profiles than the parent flavonoids. In this review, the enhanced antioxidant and anticancer activities of flavonoid metal complexes versus the parent flavonoids are discussed. Possible mechanisms of action for the metal complexes, such as DNA binding and apoptosis induction, are also presented alongside an overview of the synthesis of the metal complexes, and the different techniques used for their characterization.
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Różańska, Dorota, and Bożena Regulska-Ilow. "The importance of flavonoids in reducing blood pressure - selected aspects." Postępy Higieny i Medycyny Doświadczalnej 73 (March 27, 2019): 173–81. http://dx.doi.org/10.5604/01.3001.0013.1437.

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Hypertension is an independent risk factor for the development of cardiovascular disease. Therapy requires modifying the diet and lifestyle in order to reduce body weight. The role of flavonoids in reducing blood pressure also seems interesting. Flavonoids are plant compounds. The main classes of flavonoids are flavons, isoflavons, flavonols, flavanols, flavanones, and anthocyanins. Numerous epidemiological studies have reported that a higher intake of flavonoids in a diet is associated with a decreased risk of hypertension. One of the mechanisms by which flavonoids can help to reduce blood pressure is their activity as angiotensin-converting enzyme (ACE) inhibitors. Various flavonoids have a different ability to inhibit ACE, which is dependent on their chemical structure. The ACE inhibitor activity is associated with three structural elements of flavonoids: the catechol group on the B-ring, C2-C3 double bond and the cetone group in C4 at the C-ring. Flavonoids may exhibit ACE inhibitor activity because of compete with the substrate (competitive inhibition). One of the studies showed that flavonoid activity, as an ACE inhibitor, may be dependent on the ACE genotype (I/I, I/D, D/D). The vasodilatory properties of flavonoids can help lower blood pressure. Authors of numerous studies have shown that these properties are associated with different mechanisms, e.g. activation of potassium channels, regulation of extracellular and intracellular Ca2+ level, stimulation of nitric oxide synthase and increased synthesis of nitric oxide. Based on the studies presented in this paper, it can be concluded that flavonoids may play an important role both in preventing hypertension and in supporting its treatment.
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Zhu, Saijie, Junjun Wu, Guocheng Du, Jingwen Zhou, and Jian Chen. "Efficient Synthesis of Eriodictyol from l-Tyrosine in Escherichia coli." Applied and Environmental Microbiology 80, no. 10 (March 7, 2014): 3072–80. http://dx.doi.org/10.1128/aem.03986-13.

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ABSTRACTThe health benefits of flavonoids for humans are increasingly attracting attention. Because the extraction of high-purity flavonoids from plants presents a major obstacle, interest has emerged in biosynthesizing them using microbial hosts. Eriodictyol is a flavonoid with anti-inflammatory and antioxidant activities. Its efficient synthesis has been hampered by two factors: the poor expression of cytochrome P450 and the low intracellular malonyl coenzyme A (malonyl-CoA) concentration inEscherichia coli. To address these issues, a truncated plant P450 flavonoid, flavonoid 3′-hydroxylase (tF3′H), was functionally expressed as a fusion protein with a truncated P450 reductase (tCPR) inE. coli. This allowed the engineeredE. colito produce eriodictyol froml-tyrosine by simultaneously coexpressing the fusion protein with tyrosine ammonia lyase (TAL), 4-coumarate-CoA ligase (4CL), chalcone synthase (CHS), and chalcone isomerase (CHI). In addition, metabolic engineering was employed to enhance the availability of malonyl-CoA so as to achieve a new metabolic balance and rebalance the relative expression of genes to enhance eriodictyol accumulation. This approach made the production of eriodictyol 203% higher than that in the control strain. By using these strategies, the production of eriodictyol froml-tyrosine reached 107 mg/liter. The present work offers an approach to the efficient synthesis of other hydroxylated flavonoids froml-tyrosine or even glucose inE. coli.
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Barron, Denis, and Ragai K. Ibrahim. "Synthesis of Flavonoid Sulfates. III. Synthesis of 3′,4′-ortho Disulfates Using Sulfur Trioxide-trimethylamine Complex, and of 3′-SuIfates Using Aryl Sulfatase." Zeitschrift für Naturforschung C 43, no. 9-10 (October 1, 1988): 631–35. http://dx.doi.org/10.1515/znc-1988-9-1002.

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Abstract A number of flavonoid 3′,4′-disulfates were synthesized from the corresponding 4′-sulfate esters, using sulfur trioxide-trimethylamine complex. Desulfation of the sulfate esters using aryl sulfatase demonstrated that the rate of hydrolysis of the 3′-sulfate group was slower than either the 7- or 4′ groups, thus allowing the specific synthesis of flavonol 3,3′-disulfates. The effects of ortho-disulfation on the 13C NMR spectra of flavonoids, and the regative FAB-MS spectra of diand trisulfated flavonoids are discussed.
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Dissertations / Theses on the topic "Flavonoids – Synthesis"

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Schicker, Susanna Heidi. "Synthesis of intermediates for chalcone and 6-MSA biosynthesis." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336910.

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Baugaard, Carlo. "The synthesis and electrochemical studies of chalcones and flavanones: an investigation of their antioxidant activity." Thesis, University of Western Cape, 2013. http://hdl.handle.net/11394/3312.

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>Magister Scientiae - MSc
Flavonoids, one of the biggest classes of secondary metabolites, are found abundantly in nature in a broad range of fruits, vegetables and beverages such as tea, coffee, beer, wine and fruit drinks. Flavonoids have been reported to exert multiple biological functions as well as tremendous pharmacological activity, including anticancer activity, protection, antioxidant activity, cardiovascular protection, antibacterial, antifungal and antiviral activity. The antioxidant activity of flavones is reported to be associated with those bearing hydroxyl functions. In the present study, several reaction steps have been carried out to synthesize three sub classes of flavonoids namely; chalcones, dihydrochalcones and flavanones with various substituents attached. The first step involved protection of hydroxyl groups of acetophenone and benaldehyde as starting materials. Thereafter the Clasien Schmidt condensation reaction, under basic conditions, was performed to afford chalcone intermediates. Treatment of these chalcones with sodium acetate, under reflux, afforded flavanones as a single product in high yields. Thereafter all protecting groups where removed to yield the final products. All products and intermediates where purified by column chromatography and were characterized by Nuclear Magnetic Resonance Spectroscopy (NMR) (1H NMR and 13C NMR). An electrochemical analysis on all flavonoid compounds was performed by Cyclic Voltammetry (CV) and Square Wave Voltammetry (SWV) to give information on the accessible redox couples identified by their oxidation potentials. Oxidation potentials, which gave valuable information about reducing ability and hence the antioxidant activity, where used to compare all compounds. The antioxidant activity was observed to increase with the addition of hydroxyl groups on the B-ring. Compounds with a combination of hydroxyl groups on the A-ring and methoxy groups on the B-ring showed increased antioxidant activity when compared to those with only hydroxyl groups on the base structure. 2, 5, 4’-trihydroxy dihydrochalcone showed moderate antioxidant ability. However the 2, 5, 4’-trihydroxychalcone, containing the α, β unsaturated double bond, proved to have the greatest antioxidant ability.
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Chalumeau, Céline. "Développement d’outils chimiques pour l’élucidation de la biosynthèse des flavonoïdes du raisin : anthocyanes versus proanthocyanidines." Thesis, Bordeaux 1, 2010. http://www.theses.fr/2010BOR14188/document.

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Ces dernières années, des progrès remarquables ont été accomplis afin d’élucider la biosynthèse des flavonoïdes. Cependant les dernières étapes menant à la formation des proanthocyanidines ou tannins condensés issus de la vigne, restent à ce jour inconnues. Dans le but de déterminer si une ou plusieurs enzyme(s) spécifique(s) sont impliquées dans cette voie de biosynthèse, nous avons développé une approche de protéomique chimique, impliquant des matrices d’affinité constituées de substrats de type flavanols greffés sur un support solide. La validation de ces outils à l’aide de LDOX, une enzyme issue de Vitis vinifera a pu être menée à bien dans le cadre de ces travaux de thèse
Remarkable progress toward the complete elucidation of the biosynthesis of flavonoids has been accomplished during the last decade, but the final step leading to proanthocyanidins still remain to be elucidated, in particular, the exact nature of starter and extension units as well as the enzymatic or non enzymatic condensation process. In order to answer whether some specific enzymes are involved in the biosynthesis of grapevine proanthocyanidins, we have developped a chemical proteomics approach, with an affinity chromatography-based tool in which a flavanol type substrate is loaded on an appropriate solid support. The validation of these tools with the LDOX enzyme from Vitis vinifera was developped and performed in this Ph.D work
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Schmid, Matthias [Verfasser], and Thomas [Akademischer Betreuer] Magauer. "Biomimetic synthesis of complex flavonoids from East Indian Dragon's blood & total synthesis of salimabromide / Matthias Schmid ; Betreuer: Thomas Magauer." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1191691993/34.

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Bauer, Anne-Katrin [Verfasser], Ludger A. [Akademischer Betreuer] Wessjohann, and Wolf-Dieter [Akademischer Betreuer] Fessner. "Biocatalytic synthesis of taste-modifying flavonoids / Anne-Katrin Bauer ; Ludger A. Wessjohann, Wolf-Dieter Fessner." Halle, 2016. http://d-nb.info/1120409942/34.

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Shih, Chun-hat, and 施振翮. "Molecular characterization and metabolic engineering of flavonoid biosynthesis in higher plants." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B41633829.

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Castell, Auví Anna. "The effects of grape seed procyanidin extract on insulin synthesis and secretion." Doctoral thesis, Universitat Rovira i Virgili, 2012. http://hdl.handle.net/10803/79133.

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Las procianidinas son compuestos bioactivos presentes en frutas y vegetales. Aunque se conocen los efectos beneficiosos de estos compuestos en la homeostasis de la glucosa, su acción en la funcionalidad de la célula β no es clara. La presente tesis doctoral se ha centrado en describir los efectos de las procianidinas en la síntesis y secreción de insulina. Nuestros resultados muestran la capacidad de las procianidinas de modificar la funcionalidad de la célula β aumentando la relación insulina plasmática/mRNA, aunque la efectividad del tratamiento depende de la situación fisiológica. En situaciones no patológicas, las procianidinas afectan la insulinemia modificando la síntesis, secreción y/o degradación de la insulina. En situaciones de resistencia a la insulina, el tratamiento crónico con procianidinas disminuye la síntesis y secreción de insulina gracias a su acción limitando el acúmulo de lípidos. En cambio, en un modelo más dañado (obesidad genética), las procianidinas ejercen efectos similares pero no son capaces de mejorar la hipersinulinemia. En conclusión, las procianidinas, en las dosis ensayadas, pueden utilizarse únicamente como compuestos bioactivos limitando la disfuncionalidad de la célula β en sus estados iniciales.
Les procianidines són compostos bioactius presents en fruites i vegetals. Tot i que es coneixen els efectes beneficiosos d’aquests compostos en l’homeòstasi de la glucosa, la seva acció en la funcionalitat de la cèl•lulaβ no és clara. La present tesi doctoral s’ha centrat en descriureels efectes de les procianidines en la síntesi i secreció d’insulina. Els nostres resultats mostren la capacitat de les procianidines de modificar la funcionalitat de la cèl•lula β augmentant la relació insulina plasmàtica/mRNA, tot i que l’efectivitat del tractamentdepèn de la situaciófisiològica. En situacions no patològiques, les procianidines afecten la insulinèmia modificant la síntesi, secreciói/o degradació d’insulina. En situacions de resistència a la insulina, el tractamentcrònicamb procianidines disminueix la síntesi i secreció d’insulina gràcies a la seva acció limitant l’acumulació de lípids. En canvi, en un model més danyat (obesitat genètica), les procianidines exerceixen efectes similars però no son capaces de millorar la hiperinsulinèmia. En conclusió, les procianidines, en les dosis assajades, podenutilitzar-seúnicament coma compostos bioactiuslimitant la disfuncionalitat de la cèl•lula β en els seus estats inicials.
Procyanidins are bioactive compounds found in fruits and vegetables widely consumed. It has been reported that procyanidins show some beneficial effects on glucose homeostasis, although their effects on β-cell functionality remain unresolved. This doctoral thesis is focus on describing the effects of procyanidins on insulin synthesis and secretion. Our results showed that procyanidins modify β-cell functionality through increasing the plasma insulin/mRNA ratio, although the effectiveness of the treatment depends on the physiological situation. Under non-pathological situation, procyanidins affected insulinaemia by modifying insulin synthesis, secretion and/or degradation activity. Under insulin-resistance situation, chronic procyanidins administration decreased insulin synthesis and secretion, thanks to its lipid-lowering effect. Otherwise in a more damaged model, Zucker fatty rat, procyanidins treatment is not able to reduce insulin plasma levels although they repress insulin expression. In conclusion, procyanidins could be used as bioactive compound to limit β-cell dysfunctions under high-palatable diets, but at the assayed doses, it is not enough to counteract a strong metabolic disruption.
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GONZALEZ, EMMANUEL. "Contribution a l'etude des flavonoides. Synthese et activite anti-radicalaire de flavonols isolement, identification et syntheses d'anthocyanes." Université Louis Pasteur (Strasbourg) (1971-2008), 2000. http://www.theses.fr/2000STR13077.

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Le travail decrit dans cette these porte sur la famille des flavonoides et en particulier sur les flavonols et les anthocyanes. Dans la premiere partie, nous presentons une nouvelle methode de synthese de flavonols basee sur le rearrangement de baker-venkataraman, a partir de reactifs communs peu couteux, et donnant de bons rendements globaux. Les reactions utilisees ne mettent pas en uvre des oxydants puissants prejudiciables a des substituants sensibles ou au flavonol synthetise lui-meme. Nous avons ainsi prepare une serie homologue de flavonols dont nous avons mesure et compare l'efficacite reductrice vis-a-vis du radical stable colore 1, 1-diphenyl-2-picryl-hydrazyle (dpph) en solution modele. Une echelle relative du pouvoir antioxydant incluant l'acide ascorbique, un antioxydant bien connu, a ete construite. La comparaison de l'efficacite anti-radicalaire des flavonols a permis de degager des relations reliant leur structure a leur reactivite. Dans la deuxieme partie, nous exposons la synthese d'anthocyanes substituee en position 4 par des chaines alkyles, montrant une relative stabilite de leur couleur dans des conditions inhabituelles. En modifiant la longueur et la nature de la chaine alkyle, on modifie egalement la coloration resultante qui va du jaune au bleu. Nous avons etudie les anthocyanes responsables de la couleur des fleurs rouges et de la couleur des fleurs violettes du cultivar festival de petunia hybrida. Nous avons cherche, isole et identifie par diverses techniques spectroscopiques les anthocyanes du milieu vacuolaire afin d'en determiner le ph. Nous y avons decouvert deux nouvelles anthocyanes de structures complexes jamais decrites dans la litterature.
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Keßberg, Anton. "Enantioselektive Synthese bioaktiver Flavane und Isoflavane." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-236526.

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Im Rahmen dieser Arbeit wird eine neuartige Deoxygenierungskaskade von Flavanonen bzw. Isoflavanonen via asymmetrischer Transferhydrierung (ATH) beschrieben. Diese Methodik ermöglicht einen einstufigen Zugang zu enantiomerenreinen Flavanen bzw. Isoflavanen aus entsprechenden racemischen Ketonen. Unter Verwendung der ATH-Deoxygenierungskaskade werden hoch enantioselektive Naturstoffsynthesen elaboriert. So erfolgt eine effiziente Darstellung der Flavane Brosimin A, Brosimin B, Brosimacutin L, Kazinol U und 7,3‘-Dihydroxy-4‘-methoxyflavan. Darüber hinaus wird mittels dynamischer kinetischer Racematspaltung die Totalsynthese der Isoflavane Equol, Manuifolin K und Eryzerin D beschrieben.
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Caldwell, Stuart Thomas. "The synthesis of isotopically labelled flavonoid glucosides." Thesis, University of Glasgow, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250932.

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Books on the topic "Flavonoids – Synthesis"

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Nesbitt, Karl. Studies in the synthesis of neoflavens. Dublin: University College Dublin, 1998.

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Murphy, Rosemary A. Studies in the synthesis of azaflavanoids and azaaurones. Dublin: University College Dublin, 1997.

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Rea, Martin D. Studies in the synthesis of neoflavonoids. Dublin: University College Dublin, 1997.

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Byrne, Maeve. The synthesis and cyclisation of 2-bromo-3-ethoxypropanones. Dublin: University College Dublin, 1998.

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Grotewold, Erich. The Science of Flavonoids. Springer, 2005.

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Grotewold, Erich. The Science of Flavonoids. Springer, 2007.

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The Science of Flavonoids. Springer, 2005.

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Book chapters on the topic "Flavonoids – Synthesis"

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Bezuidenhoudt, Barend C. B., and Daneel Ferreira. "Enantioselective Synthesis of Flavonoids." In Plant Polyphenols, 143–65. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3476-1_9.

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Kitamura, S. "Transport of Flavonoids: From Cytosolic Synthesis to Vacuolar Accumulation." In The Science of Flavonoids, 123–46. New York, NY: Springer New York, 2006. http://dx.doi.org/10.1007/978-0-387-28822-2_5.

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Uyama, Hiroshi, and Young-Jin Kim. "Synthesis and Applications of Polymeric Flavonoids." In Antioxidant Polymers, 55–86. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118445440.ch3.

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van Rensburg, Hendrik, Reinier J. J. Nel, Pieter S. van Heerden, Barend B. C. B. Bezuidenhoudt, and Daneel Ferreira. "Enantioselective Synthesis of Flavonoids: Dihydroflavonols and Flavan-3-ols." In Plant Polyphenols 2, 147–62. Boston, MA: Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4139-4_8.

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Chouhan, Sonam, Kanika Sharma, Sanjay Guleria, and Mattheos A. G. Koffas. "Microbial Production of Flavonoids." In Systems and Synthetic Biotechnology for Production of Nutraceuticals, 93–128. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-15-0446-4_5.

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Sharma, Ajay, Hardeep Singh Tuli, and Anil K. Sharma. "Chemistry and Synthetic Overview of Flavonoids." In Current Aspects of Flavonoids: Their Role in Cancer Treatment, 23–38. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-5874-6_3.

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van Tunen, A. J., and J. N. M. Mol. "Control of flavonoid synthesis and manipulation of flower colour." In Developmental Regulation of Plant Gene Expression, 94–130. Dordrecht: Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3052-3_4.

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Gerats, Anton G. M., and Cathie Martin. "Flavonoid Synthesis in Petunia Hybrida; Genetics and Molecular Biology of Flower Colour." In Phenolic Metabolism in Plants, 165–99. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3430-3_6.

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Talhi, Oualid, Diana C. G. A. Pinto, and Artur M. S. Silva. "The French Paradox at Tea Time: From Antioxidant Flavonoids and Stilbenes Toward Bio-inspired Synthetic Derivatives." In Recent Advances in Redox Active Plant and Microbial Products, 149–89. Dordrecht: Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-8953-0_6.

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"Synthesis of Dietary Phenolic Metabolites and Isotopically Labeled Dietary Phenolics." In Flavonoids and Related Compounds, 253–300. CRC Press, 2012. http://dx.doi.org/10.1201/b11872-17.

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Conference papers on the topic "Flavonoids – Synthesis"

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Chubukova, O. V., Z. R. Vershinina, R. T. Matnyazov, and Al Kh Baymiev. "Using nod genes control system to create rhizospheric microorganisms with regulated gene expression." In 2nd International Scientific Conference "Plants and Microbes: the Future of Biotechnology". PLAMIC2020 Organizing committee, 2020. http://dx.doi.org/10.28983/plamic2020.054.

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Abstract:
Inducible vector containing the full-sized nodD gene and the promoter region of the nod-box under the control of which was cloned the gfp gene was constructed. Modified bacteria R. galegae in which the synthesis of GFP protein was activated by plant flavonoids were obtained.
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Latif, Muhammad Sohail, Faridah Kormin, Muhammad Kamarulzaki Mustafa, Ida Idayu Mohamad, Muhammad Khan, Sameera Abbas, Muhammad Ihsan Ghazali, et al. "Effect of temperature on the synthesis of Centella asiatica flavonoids extract-mediated gold nanoparticles: UV-visible spectra analyses." In PROCEEDINGS OF THE 3RD INTERNATIONAL CONFERENCE ON APPLIED SCIENCE AND TECHNOLOGY (ICAST’18). Author(s), 2018. http://dx.doi.org/10.1063/1.5055473.

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Ghosh, Manik, Julio A. Seijas, Barij N. Sinha, M. Pilar Vázquez-Tato, and Xesús Feás. "Flavonoids and Phenolic Compounds from Litsea polyantha Juss. bark." In The 18th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2014. http://dx.doi.org/10.3390/ecsoc-18-b016.

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Shrimal, Sheetal, and Anamika Jain. "Synthesis, characterization and biological activity of flavonoid derivatives with amine." In PROF. DINESH VARSHNEY MEMORIAL NATIONAL CONFERENCE ON PHYSICS AND CHEMISTRY OF MATERIALS: NCPCM 2018. Author(s), 2019. http://dx.doi.org/10.1063/1.5098617.

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"Synthesis and Characterization of Gold Nanoparticles Using Sigmoidin B Flavonoid for Biological Applications." In International Conference on Advances in Science, Engineering, Technology and Natural Resources. International Academy of Engineers, 2016. http://dx.doi.org/10.15242/iae.iae1116439.

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Lukasiewicz, Marcin, and Stanislaw Kowalski. "Enhancement of flavonols water solubility by cyclodextrin inclusion complex formation - case study." In The 17th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2013. http://dx.doi.org/10.3390/ecsoc-17-b005.

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Yordi, Estela, Raul Koeling, Yailé Mota, Maria João Matos, Lourdes Santana, Eugenio Uriarte, and Enrique Molina. "Application of KNN algorithm in determining the total antioxidant capacity of flavonoid-containing foods." In The 19th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2015. http://dx.doi.org/10.3390/ecsoc-19-e002.

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Cavallaro, Valeria, Ana Estévez Braun, Angel Gutiérrez Ravelo, and Ana Murray. "Sulphated flavonoid isolated from Flaveria bidentis and its semisynthetic derivatives as potential drugs for Alzheimer´s disease." In The 17th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2013. http://dx.doi.org/10.3390/ecsoc-17-b011.

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Sousa, Emília, Ana Rita Neves, Marta Correia-da-Silva, Patrícia M. A. Silva, Diana Ribeiro, Hassan Bousbaa, and Madalena Pinto. "Synthesis and Tumor Cell Growth Inhibitory Effects of New Flavonosides and Xanthonosides." In 3rd International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2017. http://dx.doi.org/10.3390/ecmc-3-04688.

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Rauter, Amélia Pilar, and Ana Marta de Matos. "Design and synthesis of CNS-targeted drug-like flavonoid analogues with potential against Alzheimer’s disease and type 2 diabetes." In The 20th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2016. http://dx.doi.org/10.3390/ecsoc-20-b010.

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