Academic literature on the topic 'Flavonodis'
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Journal articles on the topic "Flavonodis"
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Nguyen, Thuy Nga, Courtney Millar, Douglas Kiel, Marian Hannan, and Shivani Sahni. "Intake of Flavonoids and Odds of Frailty Onset in Adults in the Framingham Offspring Cohort." Innovation in Aging 5, Supplement_1 (December 1, 2021): 1009. http://dx.doi.org/10.1093/geroni/igab046.3618.
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Abstract Polyphenols (antioxidants derived from plant-foods) could play a role in inhibition of oxidative stress and frailty reduction, yet data on the polyphenol subclass of dietary flavonoids is limited. This study sought to determine the association between dietary flavonoids and frailty onset in middle-aged and older adults. This prospective cohort study included non-frail individuals from the Framingham Offspring Cohort (FOC) with total flavonoid intake (mg/day; defined as sum flavonols, flavan-3-ols, flavonones, flavones, and anthocyanins via Harvard Food Frequency Questionnaire), frailty (via Fried phenotype), and covariate information measured at baseline (1998-2001). Follow-up frailty was evaluated in 2011-2014. Logistic regression estimated odds ratio (OR) and 95% confidence intervals (95% CI) adjusting for relevant confounders. Participants (n=1,701; 55.5% female) had a mean age of 58.4 years (SD ± 8.3). Mean flavonoid intake was 309 mg/d (SD ± 266). After 12.4 years (SD ± 0.8), 224 (13.2%) individuals exhibited frailty. In age and sex adjusted models, every 50 mg/day of higher total flavonoid intake was associated with 3% reduced odds of frailty [OR (95%CI): 0.97 (0.94-1.00), p-value: 0.05). Further adjustment for smoking, energy and protein intake, and disease indicators did not appreciably change the association, and associations became non-significant (p-value=0.12). Thus, there was no association between flavonoid intake and odds of frailty onset in adults in the FOC. This could be due to participants' higher intake of flavonoids compared to average intake of ~200 mg/d in Americans.
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Wollenweber, Eckhard, Marion Dörr, and Matthias Christ. "Flavonoid Aglycones from the Leaf and Stem Exudates of Some Geraniaceae Species." Natural Product Communications 6, no. 1 (January 2011): 1934578X1100600. http://dx.doi.org/10.1177/1934578x1100600105.
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Six species of Pelargonium and one species of Geranium were studied for their surface flavonoids. Some of them were found to exhibit an unexpectedly high number of methylated flavonoids, mostly flavonols. The chemotaxonomic significance of exudate flavonoid diversification is shortly addressed.
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Li, Chengshuai, Lijing Zhang, Decao Niu, Shuzhen Nan, Xiumei Miao, Xiaowei Hu, and Hua Fu. "Investigation of flavonoid expression and metabolite content patterns during seed formation of Artemisia sphaerocephala Krasch." Seed Science Research 31, no. 2 (June 2021): 136–48. http://dx.doi.org/10.1017/s096025852100012x.
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AbstractFlavonoids are a group of phenolic secondary metabolites in plants that have important physiological, ecological and economic value. In this study, using the desert plant Artemisia sphaerocephala Krasch. as the sample material, the content and components of the total flavonoids in its seeds at seven different developmental stages were determined. In addition, the genes involved in flavonoid metabolism were identified by full-length transcriptome sequencing (third-generation sequencing technology based on PacBio RS II). Their expression levels were analysed by RNA-seq short reading sequencing, to reveal the patterns and regulation mechanisms of flavonoid accumulation during seed development. The key results were as follows: the content of total flavonoids in mature seeds was 15.05 mg g−1, including five subclasses: flavonols, chalcones, flavones, flavanones and proanthocyanidins, among which flavonols accounted for 45.78%. The period of rapid accumulation of flavonoids was 40–70 d following anthesis. The high expression of phenylalanine ammonia-lyase (PAL), 4-coumarate-CoA ligase (4CL) and UDP-glucose:flavonoids 3-o-glucosyltransferase (UF3GT) promoted the accumulation of total flavonoids, while the high expression of flavonoids 3′-hydroxylase (F3′H) and flavonols synthase (FLS) made flavanols the main component. Transcription factors such as the MYB-bHLH-WDR (MBW) complex and Selenium-binding protein (SBP) directly regulated the structural genes of flavonoid metabolism, while C2H2-type zinc finger (C2H2), Zinc-finger transcription factor (GATA), Dehydration-responsive element binding (DREB), Global Transcription factor Group E protein (GTE), Trihelix DNA-binding factors (Trihelix) and Phytochrome-interacting factor (PIF) indirectly promoted the synthesis of flavonoids through hormones such as brassinoidsteroids (BRs) and abscisic acid (ABA). These results provided valuable resources for the application of related genes in genetics and breeding.
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Nikolova, M., and S. Ivancheva. "Distribution of Surface Flavonoids in Bulgarian Plants." Natural Product Communications 1, no. 11 (November 2006): 1934578X0600101. http://dx.doi.org/10.1177/1934578x0600101119.
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The review describes the distribution of surface flavonoids in Bulgarian plants. More than 100 species of Asteraceae, Lamiaceae, Scrophulariaceae, Geraniaceae and other families have been checked for external flavonoid aglycones. The flavonoid profiles of Asteraceae species are composed of a wide array of flavones and flavonols, mainly based upon 6-substituted derivatives. Flavone aglycones are predominant in the exudates of Lamiaceae species. Apigenin, luteolin and their derivatives were most commonly found in the studied species of Scropulariaceae and Lamiaceae. It has been shown that species of Geraniaceae, Ranunculaceae, and Solanaceae contain flavonoids of the flavonol class as surface constituents. Surface distributed flavonoids appear to have been well studied and useful for chemotaxonomy. If there is not too much infraspecific variation, flavonoid profiles can be used as taxonomic characters to distinguish species. Correlations between external flavonoid formation and local environment are apparent.
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Wang, Lanxiang, Pui Ying Lam, Andy C. W. Lui, Fu-Yuan Zhu, Mo-Xian Chen, Hongjia Liu, Jianhua Zhang, and Clive Lo. "Flavonoids are indispensable for complete male fertility in rice." Journal of Experimental Botany 71, no. 16 (May 9, 2020): 4715–28. http://dx.doi.org/10.1093/jxb/eraa204.
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Abstract Flavonoids are essential for male fertility in some but not all plant species. In rice (Oryza sativa), the chalcone synthase mutant oschs1 produces flavonoid-depleted pollen and is male sterile. The mutant pollen grains are viable with normal structure, but they display reduced germination rate and pollen-tube length. Analysis of oschs1/+ heterozygous lines shows that pollen flavonoid deposition is a paternal effect and fertility is independent of the haploid genotypes (OsCHS1 or oschs1). To understand which classes of flavonoids are involved in male fertility, we conducted detailed analysis of rice mutants for branch-point enzymes of the downstream flavonoid pathways, including flavanone 3-hydroxylase (OsF3H; flavonol pathway entry enzyme), flavone synthase II (CYP93G1; flavone pathway entry enzyme), and flavanone 2-hydroxylase (CYP93G2; flavone C-glycoside pathway entry enzyme). Rice osf3h and cyp93g1 cyp93g2 CRISPR/Cas9 mutants, and cyp93g1 and cyp93g2 T-DNA insertion mutants showed altered flavonoid profiles in anthers, but only the osf3h and cyp93g1 cyp93g2 mutants displayed reduction in seed yield. Our findings indicate that flavonoids are essential for complete male fertility in rice and a combination of different classes (flavanones, flavonols, flavones, and flavone C-glycosides) appears to be important, as opposed to the essential role played primarily by flavonols that has been previously reported in several plant species.
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Vieux, Florent, Matthieu Maillot, and Adam Drewnowski. "Dietary Flavonoid Intakes in France Are Linked to Brewed Tea Consumption and to Socioeconomic Status: Analyses of the Third French Individual and National Food Consumption (INCA3) Survey for Children and Adults." Nutrients 16, no. 8 (April 10, 2024): 1118. http://dx.doi.org/10.3390/nu16081118.
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Flavonoids from green and black tea may benefit cardiovascular health. Brewed tea consumption and flavonoid intake in France have not been previously explored. This study assessed the dietary intake of flavonoids among French children and adults, using 3 days’ dietary recall for 3896 persons aged >4 y in the Third French Individual and National Food Consumption Survey (INCA3). Foods consumed by INCA 3 participants were manually matched with the flavonoid content of foods from the French PhenolExplorer database and the US Department of Agriculture expanded flavonoid database (2018 version). The six subclasses of flavonoids were flavan-3-ols, flavanones, anthocyanidins, flavonols, flavones, and isoflavones. Flavonoid intake was stratified by age subgroups (children and adults separately) and examined using socio-demographics and tea consumption patterns. Mean flavonoid intake was 210 mg/d. Flavonoids in the French diet were predominantly flavan-3-ols (147 mg/d), of which tea is the main source. The effects of age, education, income, and socio-professional category (SPC) on flavonoid intake were all significant (p < 0.0001). Brewed tea consumers were 31.88% of French adults and 3.79% of children. Brewed tea consumption and flavonoid intake were highly correlated. The highest brewed tea and flavonoid intakes were found among individuals with the highest SPC and education levels. Flavonoid intake in France was associated with brewed tea consumption and with higher education and income.
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Shen, Ting, Fengting Hu, Qianrui Liu, Haiyan Wang, and Houhua Li. "Analysis of Flavonoid Metabolites in Chaenomeles Petals Using UPLC-ESI-MS/MS." Molecules 25, no. 17 (September 2, 2020): 3994. http://dx.doi.org/10.3390/molecules25173994.
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Chaenomeles species are used for both ornamental decoration and medicinal purposes. In order to have a better understanding of the flavonoid profile of Chaenomeles, the petals of four Chaenomeles species, including Chaenomeles japonica (RB), Chaenomeles speciose (ZP), Chaenomeles sinensis (GP), and Chaenomeles cathayensis (MY), were selected as experimental material. The total flavonoid content of GP was found to be the highest, followed by MY, ZP, and RB. In total, 179 flavonoid metabolites (including 49 flavonols, 46 flavonoids, 19 flavone C-glycosides, 17 procyanidins, 15 anthocyanins, 10 flavanols, 10 dihydroflavonoids, 6 isoflavones, 5 dihydroflavonols, and 2 chalcones) were identified by Ultra-Performance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry. Screening of differential flavonoid metabolites showed that GP had higher levels of metabolites when compared with the other three Chaenomeles species. Annotation and enrichment analysis of flavonoid metabolites revealed that cyanidin 3,5-diglucoside and pelargonidin-3,5-diglucoside anthocyanins are likely responsible for the color differences of the four Chaenomeles petals. Additionally, a large number of flavonoids, flavonols, and isoflavones were enriched in the petals of GP. This study provides new insights into the development and utilization of Chaenomeles petals and provides a basis for future investigations into their utilization.
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Zhao, Chenxu, Jiajia Wang, Yuxia Li, Lei Zhang, Ghazala Nawaz, Shaoyuan Wu, and Tao Xu. "Integrated Analysis of Metabolome and Transcriptome Reveals the Difference in Flavonoid Biosynthesis between the Red- and White-Sarcocarp Pomelo Fruits." Metabolites 12, no. 12 (November 23, 2022): 1161. http://dx.doi.org/10.3390/metabo12121161.
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Flavonoids are bioactive secondary metabolites that play multiple roles in plants. However, studies on the flavonoid accumulation of the pomelo fruit are rare. In this study, we conducted a widely targeted metabolome analysis by using ultra-performance liquid chromatography and tandem mass spectrometry and identified 550 metabolites in the sarcocarp from red (C. maxima Merr. var. Tubtim Siam) and white pomelos (C. maxima (Burm.) Osbeck). A total of 263 significantly changed metabolites were detected from the 550 metabolites. Content analysis of the significantly changed metabolites (SCMs) showed that 138 SCMs were highly accumulated, whereas 125 SCMs were observed with lower content in red-sarcocarp pomelo. Importantly, 103 of the 263 SCMs were flavonoids, including 34 flavonoids, 29 flavonols, 18 flavonoid carbonosides, 9 dihydroflavones, 6 isoflavones, 5 anthocyanins, 1 dihydroflavonol, and 1 chalcone. Gene ontology analysis indicated that upregulated genes in red-sarcocarp pomelo were significantly enriched in GO terms related to flavonoids including flavonoid biosynthetic processes. Several important differentially expressed genes were detected in the correlation network, especially Cg2g009540 which is an orthologous gene of AtCHS, also detected in flavonoid biosynthesis networks, and which could be related to the high level of total flavonoids in the red-sarcocarp pomelo. Our study demonstrated the fluctuation of flavonoid biosynthesis in the two pomelo cultivars and laid a theoretical foundation for pomelo breeding to generate fruits with a high flavonoid content.
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Satya, Pratik, Debabrata Sarkar, Amitava Chatterjee, Srikumar Pal, Soham Ray, Laxmi Sharma, Suman Roy, et al. "Biosynthesis and Chemopreventive Potential of Jute (Corchorus capsularis and C. olitorius) Flavonoids and Phylogeny of Flavonoid Biosynthesis Pathways." Planta Medica International Open 9, no. 01 (February 7, 2022): e23-e33. http://dx.doi.org/10.1055/a-1712-7978.
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AbstractFlavonoids are valuable phytochemicals for human health and nutrition. Jute (Corchorus capsularis and C. olitorius), a vegetable rich in phenolics and flavonoids, is globally consumed for its health benefit, but the biosynthesis pathways and metabolic profiles of its flavonoids are poorly characterized. Elucidating the flavonoid biosynthesis pathways would augment the broader use of jute, including targeted synthesis of its specific flavonoids. We reconstructed the core flavonoid biosynthesis pathways in jute by integrating transcriptome mining, HPLC and flavonoid histochemistry. In C. capsularis (white jute), the flavonoid biosynthesis pathways’ metabolic flux was driven toward the biosynthesis of proanthocyanidins that mediate the acquisition of abiotic stress tolerance. However, higher levels of flavonols in C. olitorius (tossa jute) render it more suitable for nutritional and medicinal use. Jute flavonoid extract exhibited in vitro inhibition of matrix metalloproteinase-2, suggesting its potential chemopreventive and immunity-boosting roles. Using the flavonoid biosynthesis pathways profiles of 93 plant species, we reconstructed the flavonoid biosynthesis pathways phylogeny based on distance-based clustering of reaction paths. This reaction-path flavonoid biosynthesis pathways phylogeny was quite distinct from that reconstructed using individual gene sequences. Our flavonoid biosynthesis pathways-based classification of flavonoid groups corroborates well with their chemical evolution, suggesting complex, adaptive evolution of flavonoid biosynthesis pathways, particularly in higher plants.
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Karapandzova, Marija, Gjose Stefkov, Ivana Cvetkovikj, Jasmina Petreska Stanoeva, Marina Stefova, and Svetlana Kulevanova. "Flavonoids and Other Phenolic Compounds in Needles of Pinus peuce and Other Pine Species from the Macedonian Flora." Natural Product Communications 10, no. 6 (June 2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000647.
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Flavonoids and other phenolic compounds in young needles of four pine species, Pinus peuce, P. nigra, P. mugo and P. sylvestris from the Macedonian flora were investigated. The amount of total phenols and total flavonoids were determined using Folin-Ciocalteau and aluminum chloride assay, respectively. The obtained results revealed that the total phenolic content (TPC) and total flavonoids content (TFC) varied among different pine species ranging from 9.8 to 14.0 mg GAE/g and from 3.3 to 7.2 mg CE/g of dried plant material, respectively. Qualitative analysis of flavonoids and other phenolic components was made by a LC-DAD/ESI-MSn optimized chromatographic method. A total of 17 phenolic components were identified and classified as: acids (2), procyanidins (2) and flavonoid glycosides (13). The most prevalent components were flavonoid glycosides, especially flavonols and methylated flavonols (9). Additionally, 3 components were found as acylated flavonol glycosides with ferulic and p-coumaric acid. The last one was found not only in esterified form but also in the free form. Only one flavone-apigenin glycoside was detected. Procyanidins were identified as catechin derivatives, both dimers and trimers.
Dissertations / Theses on the topic "Flavonodis"
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Coqueiro, Aline [UNESP]. "Fracionamento bioguiado para selação de substâncias antioxidante, antimalárica e antibiótica potenciais nas espécies Kielmeyera variabilis (Clusiaceae) e Brosimum Glaziovii (Moraceae)." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/105815.
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Os testes biológicos realizados por pesquisadores colaboradores do NuBBE para as espécies selecionadas para este estudo Brosimum glaziovii e Kielmeyera variabilis indicaram K. variabilis como uma importante fonte de metabólitos especiais bioativos. O fracionamento bioguiado da fração AcOEt dos galhos de K. variabilis para isolamento de substâncias com potencial antimalárico foi realizado via teste químico com -hematina e in vitro com Plasmodium falciparum, levando a identificação das xantonas oxigenadas 3,6-diidroxi-1,4,8-trimetoxixantona, 3,5-diidroxi-4-metoxixantona, 3,4-diidroxi-6,8-dimetoxixantona, 3,4-diidroxi-2-metoxixantona, 5-hidroxi-1,3- dimetoxixantona, 2,3-dimetoxi-4-hidroxixantona, 3-hidroxi-2-metoxixantona e 2-hidroxi- 1-metoxi-xantona e o xantonolignóide kielcorina. Dentre as substâncias isoladas, o xatonolignóide kielcorina foi considerado ativo quando comparado ao padrão cloroquina. A avaliação do potencial tripanocida também foi realizada para as xantonas isoladas e dentre estas, a 3,4-diidroxi-2-metoxixantona foi a mais ativa, principalmente para a cepa resistente ao benzonidazol (cepa Bolívia). Na fração EHFB das folhas de B. glaziovii foi observado o potencial antichagásico desta espécie. Os resultados observados para os ensaios antioxidantes levaram ao isolamento dos flavonóides quercitrina, podocarpusflavona A e da mistura de quercetina-3-Oglicosídeo e quercetina-3-O-galactosídeo, evidenciando a importância dos grupos catecólicos na potencialização da ação antioxidante. O estudo bioguiado pela atividade antimicrobiana com seis cepas de Staphylococcus aureus resistentes à meticilina culminou no isolamento de um derivado prenilado do floroglucinol (HGK-1) o qual demonstrou ser responsável pela potente atividade demonstrada pela fração hexânica dos galhos de K. variabilis. As xantonas isoladas tiveram seu potencial antimicrobiano...
Several biological activities have been carried out by NuBBE’s collaborators aiming the identification of active extracts from plant species, and Brosimum glaziovii and Kielmeyera variables showed to be important sources of bioactive secondary metabolites. Bio-guided fractionation of the EtOAc bioactive fraction of the branches of K. variabilis by using of the chemical test -hematin, and in vitro by using of Plasmodium falciparum, led to the isolation and identification of oxygenated xanthones 3,6-dihydroxy-1,4,8-trimethoxyxanthone, 3,5-dihydroxy-4-methoxyxanthone, 3,4- dihydroxy-6,8-dimethoxyxanthone, 3,4-dihydroxy-2-methoxyxanthone, 1,3-dimethoxy- 5-hydroxyxanthone, 2,3-dimethoxy-4-hydroxyxantona, 3-hydroxy-2-methoxyxanthone and 2-hydroxy-1-methoxyxanthone and xantonolignoid kielcorin. Among the compounds isolated, the xatonolignoid keilcorine indicated activity when compared to the standard chloroquine. The assessment of potential trypanocidal was also a part of this work and among the isolated xanthones, 3,4-dihydroxy-2-methoxyxanthone showed to be the most active, especially against the resistant strain to benzonidazole (Bolivia strain). In hexane fraction of leaves from B. glaziovii was noted antichagasic potencial for this specie. The antioxidant test used in this study led to the isolation of several flavonoids with antioxidant activity: quercitrin, podocarpusflavone A and the mixture of quercetin-3-O-glucoside and quercetin-3-O-galactoside, showing the importance of catechol group for the potentiating of antioxidant activity. The bio-guided antimicrobial activity using six strains of methicillin-resistant Staphylococcus aureus resulted in the isolation of the prenylated phloroglucinol derivative (HGK-1), which proved to be responsible for the potent activity exhibited by the hexane extract of the branches of K. variabilis. The xanthones isolated were evaluated... (Complete abstract click electronic access below)
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Caruso, Ícaro Putinhon [UNESP]. "Estudo da interação entre flavonóides e a albumina do soro humano." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/87502.
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Os flavonóides são uma grande classe de polifenóis ocorrendo de forma natural amplamente distribuídos nas plantas, essas moléculas exibem algumas atividades farmacológicas importantes como anti-inflamatória, antioxidante, anticancerígena e antibacteriana. A interação entre os flavonóides Rutina (Ru) e Guaijaverina (Gua) e a Albumina do Soro Humano (HSA) em pH 7,0 fisiológico foi investigado usando a técnica de espectroscopia de fluorescência de estado estacionário, cálculo ab initio e de modelagem molecular. A partir da supressão de fluorescência da HSA pelos flavonóides, a constante de supressão de Stern-Volmer ( SVK ) e sua forma modificada ( aK ) foram calculadas em 298, 303 e 308 K, como também os parâmetros termodinâmicos correspondentes H , G e S , para cada flavonóide. A análise do equilíbrio de ligação foi utilizada para determinar os valores do número de sítios de ligação ( n ) e a constante de ligação ( bK ) para a Rutina e a Guaijaverina em 298, 303 e 308 K. A distância média entre o doador (HSA-214Trp ) e o aceitador (Ru e Gua) foi estimada de acordo com a teoria de transferência de energia ressonante fluorescente. A otimização geométrica dos flavonóides Rutina e Guaijaverina foi realizada nos seus estados fundamentais usando o funcional DFT/B3LYP ab initio com um conjunto de bases 6-31G(d,p) utilizado nos cálculos. O cálculo de modelagem molecular indica que os flavonóides se localizam no sítio I da HSA, dentro do bolso hidrofóbico do subdomínio IIA. Os resultados teóricos obtidos pela modelagem molecular corroboram com os dados de espectroscopia de fluorescência
Flavonoids are a large class of naturally occurring polyphenols widely distributed in plants, these molecules exhibit some important pharmacological activities like anti-inflammatory, antioxidant, anticancer, and antibacterial. The interaction between Rutina and Guaijaverin flavonoids and Human Serum Albumin (HSA) at physiological pH 7.0 was investigated by using the technique of fluorescence spectroscopy, ab initio and molecular modeling calculation. From the fluorescence quenching of the HSA by flavonoids, the Stern-Volmer quenching constant ( SVK ) and its modified form ( aK ) were calculated at 298 , 303 and K308 , as well as the corresponding thermodynamic parameters H , G and S , for each flavonoid. Analysis of binding equilibria was utilized to determine the number of binding sites ( n ) and binding constants ( bK ) values for Rutin and Guaijaverin at 298 , 303 and K308 . The average distance between donor (HSA-214Trp ) e acceptor (Ru and Gua) was estimated according to the theory of fluorescence resonance energy transfer. The geometry optimization of Rutin and Guaijaverin flavonoids was performed in its ground state by using ab initio DFT/B3LYP functional with a 6-31G(d,p) basis set applied in calculations. Molecular modeling calculation indicated that the flavonoids are located in site I of HSA, within the hydrophobic pocket of the subdomain IIA. The theoretical results obtained by molecular modeling are corroborated by the fluorescence spectroscopy data
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Pereira, Gabriela Sterle. "Ação inibitória dos flavonoides quercetina e rutina sobre a ativação de neutrófilos humanos /." Assis, 2017. http://hdl.handle.net/11449/150482.
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Orientadora: Karina Alves de ToledoBanca: Luis Octávio Regasini
Banca: Flávia Aparecida Paina Brasil
Resumo: Rutina e Quercetina são flavonoides encontrados em diversos alimentos, incluindo aqueles indicados como complemento no tratamento de doenças inflamatórias. Durante o processo inflamatório, neutrófilos são as primeiras células a serem recrutadas por estarem diretamente relacionadas à ativação e resolução destes processos. Assim, frequentemente estas células são alvos para novos compostos anti-inflamatórios. A descrição da atividade anti-inflamatória de rutina e quercetina se estende para vários ativadores das vias clássicas dos neutrófilos. O estudo quanto aos compostos forbol ésteres, como PMA (phorbol myristate acetate), que ativam de maneira específica a sinalização da proteína quinase C, ainda são escassos.O objetivo deste trabalho foi analisar a atividade anti-inflamatória de rutina e quercetina sobre neutrófilos ativados por PMA. Para tanto, foram analisadas etapas importantes do processo inflamatório mediadas pelos neutrófilos: adesão, desgranulação, e liberação das NETs (Neutrophil Extracelular Traps). Nossos resultados demonstraram que, ativação de neutrófilos por PMA: (i) rutina e quercetina não inibem a adesão dos neutrófilos, (ii) quercetina inibe a desgranulção, (iii) ambos inibem a atividade da mieloperoxidase (MPO), assim como (iv) inibem a liberação das NETs na ausência de morte celular. Análises de docking molecular sugerem que tais eventos podem estar relacionados à geração de complexos quercetina/MPO e rutina/elastase
Abstract: Rutin and Quercetin are flavonoids found in several foods, including those indicated as a supplement in the inflammatory treatment diseases. During the inflammatory process, neutrophils are the first cells to be recruited. They are directly related to the activation and resolution of these processes. Thus, these cells often target new antiinflammatory compounds. The description of the anti-inflammatory activity of rutin and quercetin extends to several activators of classical neutrophil pathways. Studies involving forbol esters compounds, as PMA ((phorbol myristate acetate), which activate in a specific manner the protein kinase signalling, it is still poor. The aim of this study was to analyze the anti-inflammatory activity of rutin and quercetin on PMAactivated neutrophils. For this, important steps of the inflammatory process mediated by neutrophils were analyzed: adhesion, degranulation, and release of NETs (Neutrophil Extracelular Traps). Our results demonstrated that neutrophil activation by PMA: (i) rutin and quercetin did not inhibit neutrophil adhesion, (ii) quercetin inhibited degranulation, (iii) both inhibited myeloperoxidase activity (MPO), as well as (iv) both Inhibit the release of NETs in the absence of cell death. Molecular docking analyzes suggest that such events may be related to the generation of quercetin/MPO and rutin/elastase complexes
Mestre
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Coqueiro, Aline. "Fracionamento bioguiado para selação de substâncias antioxidante, antimalárica e antibiótica potenciais nas espécies Kielmeyera variabilis (Clusiaceae) e Brosimum Glaziovii (Moraceae) /." Araraquara : [s.n.], 2010. http://hdl.handle.net/11449/105815.
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Orientador: Vanderlan da Silva BolzaniBanca: Marcia Nasser Lopes
Banca: José Angelo Slveira Zuanazzi
Banca: Horácio Adolfo Heinzen Gozález
Resumo: Os testes biológicos realizados por pesquisadores colaboradores do NuBBE para as espécies selecionadas para este estudo Brosimum glaziovii e Kielmeyera variabilis indicaram K. variabilis como uma importante fonte de metabólitos especiais bioativos. O fracionamento bioguiado da fração AcOEt dos galhos de K. variabilis para isolamento de substâncias com potencial antimalárico foi realizado via teste químico com -hematina e in vitro com Plasmodium falciparum, levando a identificação das xantonas oxigenadas 3,6-diidroxi-1,4,8-trimetoxixantona, 3,5-diidroxi-4-metoxixantona, 3,4-diidroxi-6,8-dimetoxixantona, 3,4-diidroxi-2-metoxixantona, 5-hidroxi-1,3- dimetoxixantona, 2,3-dimetoxi-4-hidroxixantona, 3-hidroxi-2-metoxixantona e 2-hidroxi- 1-metoxi-xantona e o xantonolignóide kielcorina. Dentre as substâncias isoladas, o xatonolignóide kielcorina foi considerado ativo quando comparado ao padrão cloroquina. A avaliação do potencial tripanocida também foi realizada para as xantonas isoladas e dentre estas, a 3,4-diidroxi-2-metoxixantona foi a mais ativa, principalmente para a cepa resistente ao benzonidazol (cepa Bolívia). Na fração EHFB das folhas de B. glaziovii foi observado o potencial antichagásico desta espécie. Os resultados observados para os ensaios antioxidantes levaram ao isolamento dos flavonóides quercitrina, podocarpusflavona A e da mistura de quercetina-3-Oglicosídeo e quercetina-3-O-galactosídeo, evidenciando a importância dos grupos catecólicos na potencialização da ação antioxidante. O estudo bioguiado pela atividade antimicrobiana com seis cepas de Staphylococcus aureus resistentes à meticilina culminou no isolamento de um derivado prenilado do floroglucinol (HGK-1) o qual demonstrou ser responsável pela potente atividade demonstrada pela fração hexânica dos galhos de K. variabilis. As xantonas isoladas tiveram seu potencial antimicrobiano... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Several biological activities have been carried out by NuBBE's collaborators aiming the identification of active extracts from plant species, and Brosimum glaziovii and Kielmeyera variables showed to be important sources of bioactive secondary metabolites. Bio-guided fractionation of the EtOAc bioactive fraction of the branches of K. variabilis by using of the chemical test -hematin, and in vitro by using of Plasmodium falciparum, led to the isolation and identification of oxygenated xanthones 3,6-dihydroxy-1,4,8-trimethoxyxanthone, 3,5-dihydroxy-4-methoxyxanthone, 3,4- dihydroxy-6,8-dimethoxyxanthone, 3,4-dihydroxy-2-methoxyxanthone, 1,3-dimethoxy- 5-hydroxyxanthone, 2,3-dimethoxy-4-hydroxyxantona, 3-hydroxy-2-methoxyxanthone and 2-hydroxy-1-methoxyxanthone and xantonolignoid kielcorin. Among the compounds isolated, the xatonolignoid keilcorine indicated activity when compared to the standard chloroquine. The assessment of potential trypanocidal was also a part of this work and among the isolated xanthones, 3,4-dihydroxy-2-methoxyxanthone showed to be the most active, especially against the resistant strain to benzonidazole (Bolivia strain). In hexane fraction of leaves from B. glaziovii was noted antichagasic potencial for this specie. The antioxidant test used in this study led to the isolation of several flavonoids with antioxidant activity: quercitrin, podocarpusflavone A and the mixture of quercetin-3-O-glucoside and quercetin-3-O-galactoside, showing the importance of catechol group for the potentiating of antioxidant activity. The bio-guided antimicrobial activity using six strains of methicillin-resistant Staphylococcus aureus resulted in the isolation of the prenylated phloroglucinol derivative (HGK-1), which proved to be responsible for the potent activity exhibited by the hexane extract of the branches of K. variabilis. The xanthones isolated were evaluated... (Complete abstract click electronic access below)
Doutor
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Tangerina, Marcelo Marucci Pereira [UNESP]. "Extratos padronizados para o tratamento de doenças crônicas: Machaerium hirtium." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/97015.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
O uso de fitoterápicos padronizados com assegurada comprovação de eficácia e segurança tem apresentado resultados terapêuticos surpreendentes em diversos países. Contudo, no Brasil, onde há grande potencial de produção de fitoterápicos devido a sua enorme biodiversidade, há deficiências na correta caracterização química das matérias-primas e escassez de ensaios farmacológicos e toxicológicos desses materiais, etapas essenciais para assegurar eficácia e segurança dos fitoterápicos. Machaerium hirtum (Fabaceae) é utilizada popularmente para o tratamento de diarréia, tosse e câncer. Um estudo químico que identifique as substâncias presentes nesta espécie e as quantifique pode fornecer subsídios para o entendimento destas atividades. A primeira etapa consistiu no isolamento das substâncias do extrato EtOH 70% das partes aéreas de M. hirtum por meio de cromatografia de permeação em gel seguida de purificação das substâncias por HPLC-RI. A identificação das substâncias foi feita por Ressonância Magnética Nuclear e por Espectrometria de Massas. O perfil químico do extrato foi estabelecido por HPLC-PDA e a quantificação das substâncias foi feita com base em suas agliconas, pelo método da calibração externa. Foi possível identificar as flavonas saponarina (8,69 ± 0,46 mg/g de extrato), isovitexina (6,44 ± 0,45 mg/g de extrato), isoorientina, que se apresentou abaixo do limite de quantificação (LOQ) e swertisina, presente no perfil cromatográfico em co-eluição com outra substância. Tais resultados são fundamentais para a padronização do extrato EtOH 70% das folhas de Machaerium hirtum
The use of standardized phytomedicines with proven efficacy and safety has shown surprising therapeutic results in various countries. Brazil has great potential for production of herbal medicine due to its enormous biodiversity. However, there are deficiencies in the correct characterization of chemical raw materials and few reliable pharmacological and toxicological tests of these materials, essential steps to ensure efficacy and safety of herbal medicines. Machaerium hirtum (Fabaceae) is popularly used to treat diarrhea, cough and cancer. A chemical study to identify the substances present in this species may provide and quantify contributions to the understanding of these activities. The first step was the isolation of substances of 70% EtOH extract of aerial parts of M. hirtum by gel permeation chromatography followed by purification of substances by HPLC-RI. The identification of substances was performed by Nuclear Magnetic Resonance and Mass Spectrometry. The chemical profile of the extract was established by HPLC-PDA and quantification of the substances was based on their aglycones by the method of external calibration. It was possible to identify the flavones saponarin (8,69 ± 0,46 mg/g of extract), isovitexin (6,44 ± 0,45 mg/g of extract), isoorientin, which was below the limit of quantification (LOQ) and swertisin, present in the chromatographic profile in co-elution with another substance. These results are fundamental to the standardization of the crude 70% EtOH extract from the leaves of Machaerium hirtum
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Severi, Juliana Aparecida [UNESP]. "Uso sustentável da biodiversidade brasileira prospecção químico-farmacológica de plantas superiores: Guapira noxia (Nyctaginaceae)." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/97016.
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severi_ja_me_arafcf.pdf: 559901 bytes, checksum: 05c536f61d35ebf5def84058555c6940 (MD5)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Universidade Estadual Paulista (UNESP)
Esse trabalho é parte do projeto temático BIOTA-FAPESP: “Uso Sustentável da Biodiversidade Brasileira: Prospecção Químico-Farmacológica de Plantas Superiores” e visa contribuir com a caracterização do Bioma-Cerrado do estado de São Paulo, investigando espécies brasileiras de interesse químico-medicinal. Dentre as espécies com particular interesse estão as do gênero Guapira (Nyctaginaceae), com informações etnofarmacológicas de uso para problemas estomacais. G. noxia é conhecida popularmente como “Maria-mole” ou “Capa-rosa” e tem ocorrência no cerrado brasileiro. Essa espécie é utilizada na medicina popular como antiúlcera. Apesar do uso popular, ainda não há informações sobre a composição química e ensaios farmacológicos desta espécie e que cuja caracterização está sendo descrita pela primeira vez. O extrato metanólico das folhas de G. noxia foi fracionado por técnicas cromatográficas convencionais (Permeação em gel, HPLC) e a as substâncias resultantes foram identificadas através de métodos espectroscópicos (RMN, IV, UV e EM). Esse trabalho levou à identificação de oito heterosídeos de flanovóides (com três e duas unidades de açúcares) derivados da quercetina, da isorhamnetina e do kaempferol, além da alantoína e de um ciclitol. Além disso, foi estabelecido o perfil cromatográfico do extrato metanólico, juntamente com a quantificação do teor de compostos fenólicos e de flavonóides totais, com vistas à sua completa caracterização química. O estudo farmacológico do extrato metanólico evidenciou principalmente as atividades antiúlcera, antimicrobiana e imunomodulatória. A presença dos flavonóides e demais compostos fenólicos pode justificar os efeitos biológicos atribuídos à espécie. Como conclusão, este estudo contribuiu para aprofundar o conhecimento químicofarmacológico sobre Guapira noxia, que ocorre no cerrado brasileiro.
This work is part of the BIOTA-FAPESP project “Sustaintable use of the Brazilian Biodiversity: Chemical and Pharmacological Prospection on Higher Plants”, which intents to contribute to improve the knowledge of the biome Cerrado of the State São Paulo, Brazil. Species from the Guapira (Nyctaginaceae) genus have special interest, since they are used in folk medicine as antiulcerogenic agent. G. noxia is known in folk medicine as “Maria-mole” or “Capa-rosa” and occurs naturally in the Brazilian cerrado, being used due to its antiulcerogenic propertie. Although the folk use, there is no data about chemical and pharmacological studies on this species. We describe here the first chemical and pharmacological characterization. The methanolic extract of G. noxia leaves was fractionated by chromatography techniques (GPC, HPLC) and the substances were identified by spectrometric methods (NMR, MS, IR, UV). This approach led to identification of eight heterosides (two and three glycosides) of flavonoids derived from quercetin, isorhamnetin and kaempferol, besides one allantoin and one cyclitol. Moreover, we have established the HPLC/UV/DAD chromatographic profile of this extract, as well as the spectrophotometric quantification of phenolic compounds and flavonoids. Pharmacological investigations showed antiulcerogenic, antimicrobial and immunomodulatory properties of the methanolic extract. The presence of flavonoids and phenolic compounds may probably explain the pharmacologicals effects of the polar extract of G. noxia and their use in folk medicine. In conclusion, this study contributed to improve the knowledge of the chemistry and pharmacological activities of Guapira noxia, an species that occurs in the Brazilian cerrado.
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Pacífico, Mariana [UNESP]. "Estudo químico e atividades mutagênica e antiulcerogênica de Syngonanthus nitens (Bong.) Ruhland." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/97968.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Neste trabalho, foi investigada a composição química de Syngonanthus nitens (Bong.) Ruhland, espécie pertencente à família Eriocaulaceae, conhecida popularmente como “capim dourado” e amplamente utilizada para o artesanato, sendo de grande importância econômica principalmente para populações do Tocantins e Minas Gerais. Espécies dessa família são conhecidas popularmente como “sempre-vivas” e a maioria delas ocorre em Campos Rupestres do Brasil. Foram preparados extratos de capítulos e de escapos, separadamente, por maceração utilizando hexano e diclorometano e por percolação com metanol. Os extratos metanólicos foram fracionados por colunas de permeação em gel, cromatografia líquida de média pressão (MPLC), cromatografia líquida de alta eficiência, com detector de arranjo de diodo (HPLC-DAD) e com detector de índice de refração (HPLC-RI) e cromatografia em contracorrente (HSCCC). As estruturas foram caracterizadas por espectroscopia na região do ultravioleta, técnicas mono e bidimensionais de RMN e por espectrometria de massas com fonte electrospray e analisador íon trap (modo de inserção direta). Foram isoladas as substâncias: 1,3,6-triidroxi-2-metoxixantona; 1,3,6-triidroxi-2,5-dimetoxixantona; 1,5,7-triidroxi-3,6-dimetoxixantona; 1,3,6,8-tetraidroxi-2,5-dimetoxixantona; 1,3,6,8-tetraidroxi-5-metoxixantona; 7-metoxiluteolina-6-C-β-D-glicopiranosideo, 7-metoxiluteolina-8-C-β-D-glicopiranosideo, 3`,7-dimetoxiluteolina-6-C-β-D-glicopiranosideo, 6-hidroxiluteolina e luteolina. Os extratos metanólicos de capítulos e escapos de S. nitens foram avaliados quanto à atividade antiulcerogênica e mutagênica. Através do modelo de lesão ulcerativa induzida por etanol absoluto, verificou-se que os dois extratos apresentaram atividade gastroprotetora. Na dose de 500 mg kg-1 do extrato de...
In this work, the chemical composition of Syngonanthus nitens (Bong.) Ruhland was investigated. This plant belongs to Eriocaulaceae family, popularly known as “capim dourado” and widely used to make baskets and other handcraft products. It´s a very important economical specie to local communities in Tocantins ans Minas Gerais states, mainly. Plants of this family are known as “everlasting flower” and they can be found in “Campos Rupestres” vegetation in Brazil. Scapes and capitulae were extracted, sequentially, with hexane, dichloromethane and methanol. Methanol extract were fractionated by several chromatographic techniques, including gel permeation chromatography, Medium Pressure Liquid Chromatography (MPLC), High Pressure Liquid Chromatography (HPLC-DAD and HPLC-RI), High Speed Countercurrent Chromatography (HSCCC). Structures were determined by ultraviolet spectroscopy, as well as mono and bidimensional NMR techniques, besides electrospray – ion trap – mass spectrometry. The chemical study of S. nitens led to the identification of five xanthones: 1,3,6-trihydroxy-2-methoxyxanthone; 1,3,6- trihydroxy-2,5-dimethoxyxanthone; 1,5,7- trihydroxy -3,6-dimethoxyxanthone; 1,3,6,8-tetrahydroxy-2,5- dimethoxyxanthone e 1,3,6,8-tetrahyidroxyi-5-methoxyxanthone, and five flavones: 7-methoxyluteolin-6-C-β-D-glucopyranoside; 7-methoxyluteolin-8-C-β-D-glucopyranoside; 4`,7-dimethoxyluteolin-6-C-β-D-glucopyranoside; 6-hydroxyluteolin and luteolin. Pharmacological assays demonstrated that the methanol extract of capitulae and scape from S. nitens has presented gastroprotective activity in the ethanol induced ulcer model. According the results of Ames test, the mutagenicity was considered negative for all tested concentrations of the three methanol extracts, at all tested strains. The chemical data obtained in this work also added more data to the discussion of the taxonomy of Eriocaulaceae
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Uliana, Carolina Venturini [UNESP]. "Estudos da lesão ao DNA por corantes têxteis e da capacidade protetora de flavonóides empregando biossensor eletroquímico: Carolina Venturini Uliana. -." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/105701.
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000718978.pdf: 1212053 bytes, checksum: f7bb64fe79078eb690b9479543704a61 (MD5)A molécula do DNA pode ser modificada por substâncias eletrofílicas, tanto de origem exógena quanto endógena. As lesões geradas podem ser mutagênicas e contribuir para o processo de carcinogênese. Assim, desvios significativos da estrutura da dupla hélice desempenham um papel importante no metabolismo do DNA. Um biossensor voltamétrico baseado na imobilização de DNA de fita dupla (dsDNA) sobre eletrodos descartáveis foi desenvolvido para aplicação nos estudos de interação entre corantes têxteis e a molécula do DNA, na ausência e na presença de flavonóides em solução. Os eletrodos modificados foram colocados em contato com soluções de corantes têxteis da classe dos dispersos, o Disperso Orange 1 (DO1) e o Disperso Red 1 (DR1), e seus produtos de eletrólise por oxidação e por redução. A variação dos sinais de oxidação das bases guanina e adenina presentes no dsDNA imobilizado, obtidos antes e após cada interação, foi utilizada como parâmetro de análise dos resultados. O tempo para que a interação DNA:corante ocorresse foi avaliado utilizando o biossensor e estabeleceu-se 180 s. A concentração dos corantes foi analisada na faixa de 1,0 x 10-8 a 1,0 x 10-4 mol L-1, sendo que a variação do sinal voltamétrico das bases foi mais intensa para DR1 (sinais da guanina e adenina decresceram 48% e 51% do seu valor original, respectivamente), enquanto que na presença de DO1, as intensidades de corrente da guanina e adenina diminuíram 30% e 10% de seu valor original, respectivamente, quando comparada a mesma concentração dos corantes de 1,0 x 10-6 mol L-1. Além da diminuição da intensidade de corrente das bases guanina e adenina, o aparecimento de novos picos e deslocamentos do potencial de pico das bases foram observados após as interações com produtos de eletrólises. Estudos de interação também...
DNA molecule may be modified by electrophilic substances, either from endogenous or exogenous origin. Lesions generated may be mutagenic and contribute to the process of carcinogenesis. In this way, significant deviations on the double helix structure play an important role in the DNA metabolism. A biosensor based on double-stranded DNA (dsDNA) immobilization on disposable electrodes has been developed for application in interaction studies between textile dyes and DNA molecule in the absence and presence of flavonoids in solution. The modified electrodes were placed in solutions of disperse textile dyes, Disperse Orange 1 (DO1) and Disperse Red 1 (DR1), and their products of electrolyses by oxidation and reduction. The variation of the oxidation signals of guanine and adenine bases of the immobilized dsDNA, obtained before and after each interaction, was used as a parameter for analyzing the results. The time for DNA:dye interaction was evaluated using the biosensor and 180 s was established. The concentration of dyes was analyzed in the range from 1.0 x 10-8 to 1.0 x 10-4 mol L-1, and the bases voltammetric signal variation was more intense for DR1 (signals of guanine and adenine decreased 48% and 51% of its original value, respectively), whereas in the presence of DO1, the current intensities of guanine and adenine decreased by 30% and 10% of its original value, respectively, when compared the same dyes concentration of 1.0 x 10-6 mol L-1. Besides adenine and guanine current intensities decrease, the appearance of new peaks and peaks potential shifts were also observed after interactions with electrolysis products. Interaction studies were also performed by means of UV-Vis spectrophotometry in aqueous phase showed different effects of hypochromism and hiperchromism of DNA band after interactions... (Complete abstract click electronic access below)
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Pacífico, Mariana. "Estudo químico e atividades mutagênica e antiulcerogênica de Syngonanthus nitens (Bong.) Ruhland /." Araraquara : [s.n.], 2010. http://hdl.handle.net/11449/97968.
Full textAbstract:
Orientador: Lourdes Campaner dos SantosBanca: Lucienir Pains Duarte
Banca: Sidney Augusto Vieira Filho
Resumo: Neste trabalho, foi investigada a composição química de Syngonanthus nitens (Bong.) Ruhland, espécie pertencente à família Eriocaulaceae, conhecida popularmente como "capim dourado" e amplamente utilizada para o artesanato, sendo de grande importância econômica principalmente para populações do Tocantins e Minas Gerais. Espécies dessa família são conhecidas popularmente como "sempre-vivas" e a maioria delas ocorre em Campos Rupestres do Brasil. Foram preparados extratos de capítulos e de escapos, separadamente, por maceração utilizando hexano e diclorometano e por percolação com metanol. Os extratos metanólicos foram fracionados por colunas de permeação em gel, cromatografia líquida de média pressão (MPLC), cromatografia líquida de alta eficiência, com detector de arranjo de diodo (HPLC-DAD) e com detector de índice de refração (HPLC-RI) e cromatografia em contracorrente (HSCCC). As estruturas foram caracterizadas por espectroscopia na região do ultravioleta, técnicas mono e bidimensionais de RMN e por espectrometria de massas com fonte electrospray e analisador íon trap (modo de inserção direta). Foram isoladas as substâncias: 1,3,6-triidroxi-2-metoxixantona; 1,3,6-triidroxi-2,5-dimetoxixantona; 1,5,7-triidroxi-3,6-dimetoxixantona; 1,3,6,8-tetraidroxi-2,5-dimetoxixantona; 1,3,6,8-tetraidroxi-5-metoxixantona; 7-metoxiluteolina-6-C-β-D-glicopiranosideo, 7-metoxiluteolina-8-C-β-D-glicopiranosideo, 3',7-dimetoxiluteolina-6-C-β-D-glicopiranosideo, 6-hidroxiluteolina e luteolina. Os extratos metanólicos de capítulos e escapos de S. nitens foram avaliados quanto à atividade antiulcerogênica e mutagênica. Através do modelo de lesão ulcerativa induzida por etanol absoluto, verificou-se que os dois extratos apresentaram atividade gastroprotetora. Na dose de 500 mg kg-1 do extrato de... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: In this work, the chemical composition of Syngonanthus nitens (Bong.) Ruhland was investigated. This plant belongs to Eriocaulaceae family, popularly known as "capim dourado" and widely used to make baskets and other handcraft products. It's a very important economical specie to local communities in Tocantins ans Minas Gerais states, mainly. Plants of this family are known as "everlasting flower" and they can be found in "Campos Rupestres" vegetation in Brazil. Scapes and capitulae were extracted, sequentially, with hexane, dichloromethane and methanol. Methanol extract were fractionated by several chromatographic techniques, including gel permeation chromatography, Medium Pressure Liquid Chromatography (MPLC), High Pressure Liquid Chromatography (HPLC-DAD and HPLC-RI), High Speed Countercurrent Chromatography (HSCCC). Structures were determined by ultraviolet spectroscopy, as well as mono and bidimensional NMR techniques, besides electrospray - ion trap - mass spectrometry. The chemical study of S. nitens led to the identification of five xanthones: 1,3,6-trihydroxy-2-methoxyxanthone; 1,3,6- trihydroxy-2,5-dimethoxyxanthone; 1,5,7- trihydroxy -3,6-dimethoxyxanthone; 1,3,6,8-tetrahydroxy-2,5- dimethoxyxanthone e 1,3,6,8-tetrahyidroxyi-5-methoxyxanthone, and five flavones: 7-methoxyluteolin-6-C-β-D-glucopyranoside; 7-methoxyluteolin-8-C-β-D-glucopyranoside; 4',7-dimethoxyluteolin-6-C-β-D-glucopyranoside; 6-hydroxyluteolin and luteolin. Pharmacological assays demonstrated that the methanol extract of capitulae and scape from S. nitens has presented gastroprotective activity in the ethanol induced ulcer model. According the results of Ames test, the mutagenicity was considered negative for all tested concentrations of the three methanol extracts, at all tested strains. The chemical data obtained in this work also added more data to the discussion of the taxonomy of Eriocaulaceae
Mestre
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Severi, Juliana Aparecida. "Uso sustentável da biodiversidade brasileira prospecção químico-farmacológica de plantas superiores : Guapira noxia (Nyctaginaceae) /." Araraquara : [s.n.], 2007. http://hdl.handle.net/11449/97016.
Full textAbstract:
Orientador: Wagner VilegasBanca: Wagner Vilegas
Banca: Jairo Kenupp Bastos
Banca: Luiz Claudio Di Stasi
Resumo: Esse trabalho é parte do projeto temático BIOTA-FAPESP: "Uso Sustentável da Biodiversidade Brasileira: Prospecção Químico-Farmacológica de Plantas Superiores" e visa contribuir com a caracterização do Bioma-Cerrado do estado de São Paulo, investigando espécies brasileiras de interesse químico-medicinal. Dentre as espécies com particular interesse estão as do gênero Guapira (Nyctaginaceae), com informações etnofarmacológicas de uso para problemas estomacais. G. noxia é conhecida popularmente como "Maria-mole" ou "Capa-rosa" e tem ocorrência no cerrado brasileiro. Essa espécie é utilizada na medicina popular como antiúlcera. Apesar do uso popular, ainda não há informações sobre a composição química e ensaios farmacológicos desta espécie e que cuja caracterização está sendo descrita pela primeira vez. O extrato metanólico das folhas de G. noxia foi fracionado por técnicas cromatográficas convencionais (Permeação em gel, HPLC) e a as substâncias resultantes foram identificadas através de métodos espectroscópicos (RMN, IV, UV e EM). Esse trabalho levou à identificação de oito heterosídeos de flanovóides (com três e duas unidades de açúcares) derivados da quercetina, da isorhamnetina e do kaempferol, além da alantoína e de um ciclitol. Além disso, foi estabelecido o perfil cromatográfico do extrato metanólico, juntamente com a quantificação do teor de compostos fenólicos e de flavonóides totais, com vistas à sua completa caracterização química. O estudo farmacológico do extrato metanólico evidenciou principalmente as atividades antiúlcera, antimicrobiana e imunomodulatória. A presença dos flavonóides e demais compostos fenólicos pode justificar os efeitos biológicos atribuídos à espécie. Como conclusão, este estudo contribuiu para aprofundar o conhecimento químicofarmacológico sobre Guapira noxia, que ocorre no cerrado brasileiro.
Abstract: This work is part of the BIOTA-FAPESP project "Sustaintable use of the Brazilian Biodiversity: Chemical and Pharmacological Prospection on Higher Plants", which intents to contribute to improve the knowledge of the biome Cerrado of the State São Paulo, Brazil. Species from the Guapira (Nyctaginaceae) genus have special interest, since they are used in folk medicine as antiulcerogenic agent. G. noxia is known in folk medicine as "Maria-mole" or "Capa-rosa" and occurs naturally in the Brazilian cerrado, being used due to its antiulcerogenic propertie. Although the folk use, there is no data about chemical and pharmacological studies on this species. We describe here the first chemical and pharmacological characterization. The methanolic extract of G. noxia leaves was fractionated by chromatography techniques (GPC, HPLC) and the substances were identified by spectrometric methods (NMR, MS, IR, UV). This approach led to identification of eight heterosides (two and three glycosides) of flavonoids derived from quercetin, isorhamnetin and kaempferol, besides one allantoin and one cyclitol. Moreover, we have established the HPLC/UV/DAD chromatographic profile of this extract, as well as the spectrophotometric quantification of phenolic compounds and flavonoids. Pharmacological investigations showed antiulcerogenic, antimicrobial and immunomodulatory properties of the methanolic extract. The presence of flavonoids and phenolic compounds may probably explain the pharmacologicals effects of the polar extract of G. noxia and their use in folk medicine. In conclusion, this study contributed to improve the knowledge of the chemistry and pharmacological activities of Guapira noxia, an species that occurs in the Brazilian cerrado.
Mestre
Books on the topic "Flavonodis"
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M, Andersen Øyvind, and Markham Kenneth R, eds. Flavonoids: Chemistry, biochemistry, and applications. Boca Raton, FL: Taylor&Francis, 2005.
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Harborne, J. B., ed. The Flavonoids. Boston, MA: Springer US, 1994. http://dx.doi.org/10.1007/978-1-4899-2911-2.
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Harborne, J. B., ed. The Flavonoids. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4899-2913-6.
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Saini, Deepika, Rajesh K. Kesharwani, and Raj K. Keservani. The Flavonoids. New York: Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003399964.
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Kesharwani, Rajesh K., Deepika Saini, Raj K. Keservani, and Anil Kumar Sharma. Flavonoids as Nutraceuticals. New York: Apple Academic Press, 2024. http://dx.doi.org/10.1201/9781003412441.
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I︠U︡, Korulʹkin D., ed. Prirodnye flavonoidy. Novosibirsk: GEO, 2007.
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Buslig, Béla S., and John A. Manthey, eds. Flavonoids in Cell Function. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/978-1-4757-5235-9.
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Grotewold, Erich, ed. The Science of Flavonoids. New York, NY: Springer New York, 2006. http://dx.doi.org/10.1007/978-0-387-28822-2.
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Grotewold, Erich, ed. The Science of Flavonoids. New York: Springer-Verlag, 2006. http://dx.doi.org/10.1007/0-387-28822-8.
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Lester, Packer, ed. Flavonoids and other polyphenols. San Diego, Calif: Academic Press, 2001.
Find full textBook chapters on the topic "Flavonodis"
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Peer, W. A., and A. S. Murphy. "Flavonoids as Signal Molecules: Targets of Flavonoid Action." In The Science of Flavonoids, 239–68. New York, NY: Springer New York, 2006. http://dx.doi.org/10.1007/978-0-387-28822-2_9.
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Harborne, J. B. "Flavonoids." In Natural Products of Woody Plants, 533–70. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74075-6_16.
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Hodek, Petr. "Flavonoids." In Metabolism of Drugs and Other Xenobiotics, 543–82. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2012. http://dx.doi.org/10.1002/9783527630905.ch20.
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Schwab, Manfred. "Flavonoids." In Encyclopedia of Cancer, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27841-9_2204-2.
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Seigler, David S. "Flavonoids." In Plant Secondary Metabolism, 151–92. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-4913-0_11.
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Antunes-Ricardo, Marilena, and Janet Alejandra Gutiérrez-Uribe. "Flavonoids." In Phenolic Compounds in Food, 173–84. Boca Raton : CRC Press, Taylor & Francis Group, 2018.: CRC Press, 2018. http://dx.doi.org/10.1201/9781315120157-10.
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Ribeiro, Tânia Bragança, Adma Melo, Ana A. Vilas-Boas, and Manuela Pintado. "Flavonoids." In Natural Secondary Metabolites, 73–105. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-18587-8_4.
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Gangapuram, Madhavi, and Kinfe K. Redda. "Flavonoids." In Flavonoids and Anti-Aging, 1–22. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003225225-1.
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Nagu, Priyanka, Pankaj Sharma, Arun Parashar, Minaxi Sharma, Baskaran Stephen Inbaraj, Vineet Mehta, and Kandi Sridhar. "Flavonoids." In Anti-SARS-CoV-2 Activity of Flavonoids, 1–11. Boca Raton: CRC Press, 2024. http://dx.doi.org/10.1201/9781003433200-1.
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Abidharini, Jothi Dheivasikamani, Ayyadurai Pavithra, Arthi Boro, Palanisamy Sampathkumar, Ramalingam Sivakumar, Saravanan Renuka, Gunna Sureshbabu Suruthi, and Arumugam Vijaya Anand. "Flavonoids." In Anti-SARS-CoV-2 Activity of Flavonoids, 233–42. Boca Raton: CRC Press, 2024. http://dx.doi.org/10.1201/9781003433200-20.
Full textConference papers on the topic "Flavonodis"
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Djelić, Gorica, Vesna Veličković, and Milica Pavlović. "SESELI RIGIDUM WALDST. & KIT: SECONDARY METABOLITES AND ANTIOXIDANT ACTIVITY OF METHANOL, ETHYL ACETATE AND ACETONE EXTRACTS." In 2nd International Symposium on Biotechnology. University of Kragujevac, Faculty of Agronomy, 2024. http://dx.doi.org/10.46793/sbt29.34gdj.
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Representatives of the Seseli genus are recognized for their biological activities. The objective of this study was to analyze the phenolic and flavonoid content, along with the antioxidant effects, of methanol, ethyl acetate, and acetone extracts obtained from the roots, leaves, stems, and fruits of S. rigidum. Through spectrophotometric measurements of phenols and flavonoids, the results revealed that the polar (methanol) solvent extract from the leaves exhibited the highest concentrations of phenols (98.66 ± 2.64 mg GA/g) and flavonoids (20.74 ± 0.55 mg RU/g), surpassing those obtained from the stem. Specifically, the methanol extract from the leaves demonstrated the highest antioxidant activity at 25.87 ± 0.05 μg/mL, while the fruit extract exhibited the lowest antioxidant activity at 638.5 ± 0.01 μg/mL. Notably, the total phenol content displayed a strong positive correlation with the antioxidant activity of the extracts, unlike the total flavonoid content.
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Nartea, Mihaela, Maria Cojocaru-Toma, Cristina Ciobanu, Anna Benea, and Maria Cristeva. "Total content of flavonoids in species of the genus heichrysum." In Scientific seminar with international participation "New frontiers in natural product chemistry". Institute of Chemistry, Republic of Moldova, 2023. http://dx.doi.org/10.19261/nfnpc.2023.ab20.
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The genus Helichrysum (Asteraceae) comprises about 600 species of perennial or annual plants distributed in Europe, Asia, and Africa, which are an abundant source of secondary metabolites, such as flavonoids, chalcones, phenolic acids, coumarins, pyrones, and terpenes [1]. In the Republic of Moldova only one species H. arenarium (L.) Moench-(popularly known as everlasting), occurs sporadically on the cliffs of the right bank of the Nistru River, in the landscape reserve "Climăuții de jos", in the Steppe Hills steppes, on the limestones of Naslavcea, with a declining population [2]. Another species H. italicum L. is recently introduced (2021) in the collection of the Scientific Practical Centre in the Field of Medicinal Plants of “Nicolae Testemițanu” State University of Medicine and Pharmacy. We proposed identification and assay of flavonoids from species of the genus Heichrysum (H. arenarium and H. italicum). Aerial parts and flowers of H. arenarium were collected from wild flora, and for H. italicum - from the collection. Flavonoids were identified by specific reactions as well as by thin layer chromatography. Determination of flavonoids was performed with aluminium chloride using a Metertech UV/VIS SP 8001 spectrophotometer. By colour reactions and CSS in the aerial parts and flowers of H. arenarium were identified: apigenin, luteolin, rutozide, quercetin, quercitrin, while in H. italicum: apigenin, rutozide, luteolin. The flavonoid concentration (mg/ml), expressed as rutin (λ=430nm) shows a higher content in the H. arenarii flores (1.46), followed by the H. italici flores (1.31), while the flavonoid content in the aerial parts is lower and varies from 0.80 for H. italicum to 0.89 for H. arenarium. Where the total flavonoid content (mg/ml), expressed as quercetin (λ=425nm) is higher and shows 10,69 in H. arenarii flores; 9,87 in H. italici flores, followed by aerial parts (2,76 for H. italicum to 3,62 for H. arenarium) with a maximum extraction in ethanol of 50% for all products.
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Almughraby, E., M. I. Kalimullin, A. A. Mostyakova, and O. A. Timofeeva. "VARIETY SPECIFICITY OF PHYTOCHEMICAL COMPOSITION B. OLERACEA L. VAR. ACEPHALA." In STATE AND DEVELOPMENT PROSPECTS OF AGRIBUSINESS. DSTU-PRINT, 2020. http://dx.doi.org/10.23947/interagro.2020.1.340-343.
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Purpose of work - Comparative analysis the content of phenolic compounds, flavonoids, carotenoids, vitamin C, protein and sugars in different varieties of cabbage kale (B. oleracea L. convar. Acephala). As an object of study, we used 2 varieties of cabbage kale - Premier cabbage, Dwarf Blue Curled with green leaves, Redbor with red leaves and Scarlet with purple. It was shown that the content of phenolic compounds and flavonoids was significantly higher in red varieties, compared with green. The content of carotenoids was higher in green varieties. The highest content of flavonoid was found in the variety «Scarlet» and vitamin C in the variety «Redbor». However, the amount of proteins and sugars, there were no significant differences between the varieties.
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Zavodnik, I. B., E. A. Lapshina, T. V. Ilyich, A. G. Veiko, T. A. Kovalenia, and V. U. Buko. "REGULATORY, ANTIOXIDATIVE AND HEPATOPROTECTIVE EFFECTS OF PLANT POLYPHENOLS AND THEIR NANOSTRUCTURED COMPLEXES." In SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute, 2021. http://dx.doi.org/10.46646/sakh-2021-1-255-258.
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Flavonoids, secondary plant metabolites, demonstrate a wide range of biological and pharmacological activities. In our experiment, flavonoids and their complexes with cyclodextrins (10—100 gM) dose-dependently prevented lipid peroxidation of erythrocyte and mitochondrial membranes, inhibited oxidation of reduced glutathione, and modulated the proapoptotic process of the mitochondrial permeability transition pores formation, that depends on flavonoid lipophilicity and structures. Generation of maps of the electron density distribution in the quercetin molecule and the quercetin semiquinone radical shows that the active electronic orbitals of quercetin and its semiquinone radical are delocalized along the phenolic rings, which, in the case of a radical, increases radical stability. The quercetin-hydroxypropyl-e-cyclodextrin complex proved to be a more effective antioxidant.
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Rodríguez-Ramírez, Juan, Irene Chaparro-Hernández, Lilia L. Méndez-Lagunas, and Luis Gerardo Barriada-Bernal. "Effect of spray drying conditions on antioxidants activity, flavonoids and total phenolic compounds of stevia rebaudiana." In 21st International Drying Symposium. Valencia: Universitat Politècnica València, 2018. http://dx.doi.org/10.4995/ids2018.2018.7518.
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In this work the spray drying of the fresh stevia leaves aqueous extract without encapsulating agents was carried out. The effect of the inlet air temperature (160-200 ºC) and the feed flow rate (2-3 kg/h) on the total phenolic content, the total flavonoid content and the antioxidant capacity were evaluated using Folin-Ciocalteau, aluminum chloride and DPPH methods respectively. The inlet air temperature had a significant effect on all parameters evaluated that showed a decrease when increasing the inlet air temperature, the feed flow rate had a significant effect on total flavonoids content and the antioxidant capacity, by increasing the feed flow rate the inhibition of the DPPH radical decreased and the total flavonoid content increased. The treatment at 160 ºC and 3 kg/h retained highest total flavonoid content and the antioxidant capacity. Keywords: Phenolic compounds, stevia, spray drying, antioxidant capacity
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Todorović, Jovana D., Aleksandra D. Vesić, Nevena N. Petrović, and Marijana M. Kosanić. "Edible mushrooms as promising antioxidants." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.300t.
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Antioxidant activity of the acetone extracts of the mushrooms Macrolepiota procera and Chlorophyllum rhacodes has been screened in vitro by using different methods (DPPH radical scavenging and reducing power assay), and also it has been determined the total phenolic compounds as total flavonoid content. The research findings indicate that the acetone extract of M. procera demonstrated superior antioxidant activities when compared to C. rhacodes. Similarly, the mushroom M. procera displayed a more pronounced effect on reducing power. In addition, the total content of phenol and flavonoid in extracts were determined as pyrocatechol equivalent, and as rutin equivalent, respectively. A higher content of total phenols and flavonoids was detected in the extract of M. procera. The strong relationships between total phenolic and flavonoid contents and the antioxidative activities of tested extracts imply that these compounds have a significant impact on antioxidant activity. The present study highlights that the tested mushroom species exhibit potent antioxidant properties and can be regarded as valuable sources of natural antioxidants.
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Mitić, Milan, Pavle Mašković, and Jelena Mitić. "MATHEMATICAL MODELING OF TOTAL FLAVONOID COMPOUNDS EXTRACTION FROM DILL (Anethum graveolens L.) LEAVES." In XXVII savetovanje o biotehnologiji. University of Kragujevac, Faculty of Agronomy, 2022. http://dx.doi.org/10.46793/sbt27.389m.
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In this paper, extraction of the total flavonoid compounds from dill (Anethum graveolens L) leaves using an aqueous ethanol solution (50% by volume) was studied at different temperatures (30, 40, and 50 0C). A physical unsteady- state diffusion model and empirical Ponomarev model were developed to model the extraction process’s kinetics. The enthalpy and entropy changes were positive, while the Gibbs free energy was negative and decreased when temperature increased during the thermodynamic analysis. Therefore, extraction of total flavonoids from dill leaves was endothermic, spontaneous, and irreversible.
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Sovrlić, Miroslav, Nedeljko Manojlović, Marijana Kosanić, Aleksandar Kočović, Jovica Tomović, and Perica Vasiljević. "Lichenochemical analysis and in vitro antioxidant activity of extracts and gyrophoric acid from lichen Umbilicaria grisea." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.515s.
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This research investigates the chemical composition, total phenolic and flavonoid content, and antioxidant activity of acetone, methanol, and ethanol extracts of the lichen Umbilicaria grisea, and its major secondary metabolite, gyrophoric acid. The extracts were analyzed using high-performance liquid chromatography (HPLC-UV) and spectrophotometric assays. The results showed significant levels of phenolic compounds and flavonoids, which contribute to the lichen’s antioxidant potential. The antioxidant activity was evaluated using in vitro assays such as DPPH and ABTS radical scavenging activity. The extracts demonstrated potent antioxidant activity, suggesting their potential as natural antioxidants. The identification of bioactive compounds, high phenolic and flavonoid content, and significant antioxidant activity support the potential use of U. grisea as a natural source of therapeutic agents. Further studies are needed to elucidate the underlying mechanisms responsible for these biological activities and evaluate the efficacy and safety of these extracts for potential pharmaceutical applications.
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Huang, X. L., M. C. Peng, J. X. Liu, Y. Lei, X. J. Yang, and Z. H. Wu. "Hot air drying characteristics and nutrients of apricot armeniaca vulgaris lam pretreated with Radio Frequency(RF)." In 21st International Drying Symposium. Valencia: Universitat Politècnica València, 2018. http://dx.doi.org/10.4995/ids2018.2018.7524.
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Apricot pretreated with RF and then dried with convective hot air at 65℃, 3.0m/s in this research. RF pretreatment time of 20, 30, 40 and 50min were chosen. Results showed that, there is only falling rate period during apricot hot air drying, and the drying rate of apricot is improved significantly; Herdenson and Pabis model is suitable for apricot hot air drying; retentions of flavonoids, polyphenols and Vc in dried apricot were higher than those of fresh apricot; when RF treating time was chosen 30mins, nutrients retentions of Vc, flavonoid and polyphenols were 0.9543mg/100g, 5.4089mg/100g and 7.3382mg/100g, separately. Keywords: apricot fruit, hot air drying, drying rate, nutrients, radio frequency
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Djelic, Gorica, Milica Pavlović, Snežana Branković, Duško Brković, Zoran Simić, and Vesna Veličković. "CONTRIBUTION TO THE KNOWLEDGE OF THE ANTIOXIDANT POWER, PHENOLIC AND MINERAL COMPOSITION OF SANGUISORBA MINOR SCOP." In 1st International Symposium on Biotechnology. University of Kragujevac, Faculty of Agronomy, 2023. http://dx.doi.org/10.46793/sbt28.305dj.
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In this study, extracts of the aerial partsof Sanguisorba minorScop. wereanalysed for antioxidant activity, quantification of the total phenolic and flavonoid and bioaccumulation potential of heavy metals.The total phenols amounts was the highest at acetone´sextracts of root (117.27 mg GAE /g dry weight), stem and leaf (133.61 mg GAE /g dry weight ) and flower (116.77 mg GAE /g dry weight) and total flavonoids acetone´sextractsof flower (50.69 mg RU/g). The highest DPPH-scavenging capacity had flower methanol extract 7.08 (IC50 µg/ml). The plant accumulates large amounts of Zn, Ni and Cu in the root, stem and leaf and flower. Otherwise Mn, Cr and Pb are represented in whole plant.
Reports on the topic "Flavonodis"
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Phillips, Donald, and Yoram Kapulnik. Using Flavonoids to Control in vitro Development of Vesicular Arbuscular Mycorrhizal Fungi. United States Department of Agriculture, January 1995. http://dx.doi.org/10.32747/1995.7613012.bard.
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Vesicular-arbuscular mycorrhizal (VAM) fungi and other beneficial rhizosphere microorganisms, such as Rhizobium bacteria, must locate and infect a host plant before either symbiont profits. Although benefits of the VAM association for increased phosphorous uptake have been widely documented, attempts to improve the fungus and to produce agronomically useful amounts of inoculum have failed due to a lack of in vitro production methods. This project was designed to extend our prior observation that the alfalfa flavonoid quercetin promoted spore germination and hyphal growth of VAM fungi in the absence of a host plant. On the Israeli side of the project, a detailed examination of changes in flavonoids and flavonoid-biosynthetic enzymes during the early stages of VAM development in alfalfa found that VAM fungi elicited and then suppressed transcription of a plant gene coding for chalcone isomerase, which normally is associated with pathogenic infections. US workers collaborated in the identification of flavonoid compounds that appeared during VAM development. On the US side, an in vitro system for testing the effects of plant compounds on fungal spore germination and hyphal growth was developed for use, and intensive analyses of natural products released from alfalfa seedlings grown in the presence and absence of microorganisms were conducted. Two betaines, trigonelline and stachydrine, were identified as being released from alfalfa seeds in much higher concentrations than flavonoids, and these compounds functioned as transcriptional signals to another alfalfa microsymbiont, Rhizobium meliloti. However, these betaines had no effect on VAM spore germination or hyphal growth i vitro. Experiments showed that symbiotic bacteria elicited exudation of the isoflavonoids medicarpin and coumestrol from legume roots, but neither compound promoted growth or germination of VAM fungi in vitro. Attempts to look directly in alfalfa rhizosphere soil for microbiologically active plant products measured a gradient of nod-gene-inducing activity in R. meliloti, but no novel compounds were identified for testing in the VAM fungal system in vitro. Israeli field experiments on agricultural applications of VAM were very successful and developed methods for using VAM to overcome stunting in peanuts and garlic grown in Israel. In addition, deleterious effects of soil solarization on growth of onion, carrot and wheat were linked to effects on VAM fungi. A collaborative combination of basic and applied approaches toward enhancing the agronomic benefits of VAM asociations produced new knowledge on symbiotic biology and successful methods for using VAM inocula under field conditions
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Henning, Susanne. Flavonoids and DNA Repair in Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, December 2005. http://dx.doi.org/10.21236/ada448584.
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Henning, Susanne M. Flavonoids and DNA Repair in Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, December 2004. http://dx.doi.org/10.21236/ada434003.
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Busby, Ryan, David Ringelberg, and Carina Jung. Flavonoids Differentially Influence Rhizosphere Bacterial Communities from Native and Introduced Lespedeza Roots. Engineer Research and Development Center (U.S.), August 2018. http://dx.doi.org/10.21079/11681/28063.
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Gutiérrez Merino, Carlos. Flavonoides antioxidantes y salud: ¿una quimera o una lotería? Sociedad Española de Bioquímica y Biología Molecular (SEBBM), February 2014. http://dx.doi.org/10.18567/sebbmdiv_rpc.2014.02.1.
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Kozhuharova, Asya, Marina Stanilova, Milena Nikolva, Rumen Denev, and Strahil Berkov. Glycyrrhizin and Flavonoid Contents of the Bulgarian Glycyrrhiza glabra Populations. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, July 2021. http://dx.doi.org/10.7546/crabs.2021.07.05.
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Yao, Jia, Xianzhe Wang, Jia Zhao, Zhaojun Yang, Yuping Lin, Lu Sun, Yuan Zhang, Qiyun Lu, and Guanjie Fan. Flavonoids for viral acute respiratory tract infections: a systematic review and meta-analysis of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, August 2021. http://dx.doi.org/10.37766/inplasy2021.8.0107.
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Riveros Rivera, Andre Josafat, and Ximena Serrano Gil. Innovación para proteger cerebro de polinizadores Flavonoides ayudarían a las abejas a recuperar la memoria. Universidad del Rosario, March 2024. http://dx.doi.org/10.12804/dvcn_10336.42342_num7.
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El número de abejas en el planeta está disminuyendo. A esta crítica situación hay que añadir que las que quedan están perdiendo capacidades de aprendizaje. Investigadores de la Universidad del Rosario crearon una fórmula para proteger y recuperar el cerebro de polinizadores afectados por la exposición a plaguicidas.
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Eyal, Yoram, Gloria Moore, and Efraim Lewinsohn. Study and Manipulation of the Flavanoid Biosynthetic Pathway in Citrus for Flavor Engineering and Seedless Fruit. United States Department of Agriculture, October 2003. http://dx.doi.org/10.32747/2003.7570547.bard.
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The proposal was aimed to identify and functionally characterize key genes/enzymes in the citrus flavanone neohesperidoside biosynthetic pathway and to use them as tools for metabolic engineering to decrease bitterness levels in grapefruit. The proposed section on fruit seediness was dropped as suggested by the reviewers of the proposal. Citrus flavor and aroma is composed of complex combinations of soluble and volatile compounds. The former includes mainly sugars, acids and flavanones, a subgroup of flavonoids that includes bitter compounds responsible for the bitter flavor of grapefruit and pummelo. Bitter species contain mostly bitter flavanone neohesperidosides, while non-bitter species contain mostly tasteless flavanone rutinosides. Both flavanone versions are diglycosides consisting of a rhamnose-glucose oligosaccharide a-linked at position 7 to the flavanone skeleton. However, in the bitter neohesperidosides the rhamnose is attached at position 2 of the glucose moiety, while in the tasteless rutinosides the rhamnose is attached at position 6 of the glucose moiety. Thus, the position of the rhamnose moiety, determined by the specificity of the last enzymes in the pathway- rhamnosyltransferase (1,2 or 1,6 specificity), is the determinant of the bitter flavor. Flavanones, like all flavonoids are synthesized via one of the branches of the phenylpropanoid pathway; the first committed step is catalyzed by the enzyme Chalcone synthase (CHS) followed by Chalcone isomerase (CHI). During the course of the work a key gene/enzyme in the biosynthesis of the bitter flavanones, a 1,2 rhamnosyltransferase (1,2RT), was functionally characterized using a transgenic cell-culture biotransformation system, confirming that this gene is a prime candidate for metabolic engineering of the pathway. This is the first direct functional evidence for the activity of a plant recombinant rhamnosyltransferase, the first confirmed rhamnosyltransferase gene with 1,2 specificity and the second confirmed rhamnosyltransferase gene altogether in plants. Additional genes of the flavanone pathway that were isolated during this work and are potential tools for metabolic engineering include (I) A putative 1,6 rhamnosyltransferase (1,6RT) from oranges, that is presumed to catalyze the biosynthesis of the tasteless flavanones. This gene is a prime candidate for use in future metabolic engineering for decreased bitterness and is currently being functionally characterized using the biotransformation system developed for characterizing rhamnosyltransferases. (2) A putative 7-0-glucosyltransferase presumed to catalyze the first glycosylation step of the flavanone aglycones. Silencing of gene expression in grapefruit was attempted using three genes: (1) The "upstream" flavonoid biosynthesis genes CHS and CHI, by antisense and co-suppression; and (2) The "downstream" 1,2R T, by an RNAi approach. CHS and CHI silencing resulted in some plants with a dramatically decreased level of the bitter flavanone neohesperidoside naringin in leaves. We have yet to study the long-term effect of silencing these genes on tree physiology, and on the actual bitterness of fruit. The effect of 1,2RT silencing on naringin content in grapefruit has yet to be examined, but a slow growth phenotype for these plants was noted. We speculate that silencing of the final glycosylation step of the flavanones delays their evacuation to the vacuole, resulting in accumulation of flavanones in the cytoplasm, causing inhibitory effects on plant growth. This speculation is yet to be established at the product level. Future metabolic engineering experiments are planned with 1,6RT following functional characterization.
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Carraway, Robert E., and Paul Dobner. Prostate Cancer Cell Growth: Stimulatory Role of Neurotensin and Mechanism of Inhibition by Flavonoids as Related to Protein Kinase C. Fort Belvoir, VA: Defense Technical Information Center, January 2009. http://dx.doi.org/10.21236/ada499617.
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