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Journal articles on the topic 'Fission yeast'

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Author: Grafiati

Published: 4 June 2021

Last updated: 6 September 2023

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1

Cortés, Juan C. G., Mariona Ramos, Masako Osumi, Pilar Pérez, and Juan Carlos Ribas. "Fission yeast septation." Communicative & Integrative Biology 9, no. 4 (May 12, 2016): e1189045. http://dx.doi.org/10.1080/19420889.2016.1189045.

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2

Murray, Andrew W. "Sunburnt fission yeast." Nature 363, no. 6427 (May 1993): 302. http://dx.doi.org/10.1038/363302a0.

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3

Xu, Dan-Dan, and Li-Lin Du. "Fission Yeast Autophagy Machinery." Cells 11, no. 7 (March 24, 2022): 1086. http://dx.doi.org/10.3390/cells11071086.

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Autophagy is a conserved process that delivers cytoplasmic components to the vacuole/lysosome. It plays important roles in maintaining cellular homeostasis and conferring stress resistance. In the fission yeast Schizosaccharomyces pombe, autophagy is important for cell survival under nutrient depletion and ER stress conditions. Experimental analyses of fission yeast autophagy machinery in the last 10 years have unveiled both similarities and differences in autophagosome biogenesis mechanisms between fission yeast and other model eukaryotes for autophagy research, in particular, the budding yeast Saccharomyces cerevisiae. More recently, selective autophagy pathways that deliver hydrolytic enzymes, the ER, and mitochondria to the vacuole have been discovered in fission yeast, yielding novel insights into how cargo selectivity can be achieved in autophagy. Here, we review the progress made in understanding the autophagy machinery in fission yeast.

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4

Vicente-Soler, Jero, Teresa Soto, Alejandro Franco, José Cansado, and Marisa Madrid. "The Multiple Functions of Rho GTPases in Fission Yeasts." Cells 10, no. 6 (June 7, 2021): 1422. http://dx.doi.org/10.3390/cells10061422.

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The Rho family of GTPases represents highly conserved molecular switches involved in a plethora of physiological processes. Fission yeast Schizosaccharomyces pombe has become a fundamental model organism to study the functions of Rho GTPases over the past few decades. In recent years, another fission yeast species, Schizosaccharomyces japonicus, has come into focus offering insight into evolutionary changes within the genus. Both fission yeasts contain only six Rho-type GTPases that are spatiotemporally controlled by multiple guanine–nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and whose intricate regulation in response to external cues is starting to be uncovered. In the present review, we will outline and discuss the current knowledge and recent advances on how the fission yeasts Rho family GTPases regulate essential physiological processes such as morphogenesis and polarity, cellular integrity, cytokinesis and cellular differentiation.

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5

Chang, Fred, and Paul Nurse. "How Fission Yeast Fission in the Middle." Cell 84, no. 2 (January 1996): 191–94. http://dx.doi.org/10.1016/s0092-8674(00)80973-3.

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6

Johnson, Byron F., L. C. Sowden, Teena Walker, Bong Y. Yoo, and Gode B. Calleja. "Use of electron microscopy to characterize the surfaces of flocculent and nonflocculent yeast cells." Canadian Journal of Microbiology 35, no. 12 (December 1, 1989): 1081–86. http://dx.doi.org/10.1139/m89-181.

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The surfaces of flocculent and nonflocculent yeast cells have been examined by electron microscopy. Nonextractive preparative procedures for scanning electron microscopy allow comparison in which sharp or softened images of surface details (scars, etc.) are the criteria for relative abundance of flocculum material. Asexually flocculent budding-yeast cells cannot be distinguished from nonflocculent budding-yeast cells in scanning electron micrographs because the scar details of both are well resolved, being hard and sharp. On the other hand, flocculent fission-yeast cells are readily distinguished from nonflocculent cells because fission scars are mostly soft or obscured on flocculent cells, but sharp on nonflocculent cells. Sexually and asexually flocculent fission-yeast cells cannot be distinguished from one another as both are heavily clad in "mucilaginous" or "hairy" coverings. Examination of lightly extracted and heavily extracted flocculent fission-yeast cells by transmission electron microscopy provides micrographs consistent with the scanning electron micrographs.Key words: flocculation, budding yeast, fission yeast, scanning, transmission.

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7

Emami, Parvaneh, and Masaru Ueno. "3,3’-Diindolylmethane induces apoptosis and autophagy in fission yeast." PLOS ONE 16, no. 12 (December 10, 2021): e0255758. http://dx.doi.org/10.1371/journal.pone.0255758.

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3,3’-Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, found in the broccoli family. It induces apoptosis and autophagy in some types of human cancer. DIM extends lifespan in the fission yeast Schizosaccharomyces pombe. The mechanisms by which DIM induces apoptosis and autophagy in humans and expands lifespan in fission yeasts are not fully understood. Here, we show that DIM induces apoptosis and autophagy in log-phase cells, which is dose-dependent in fission yeast. A high concentration of DIM disrupted the nuclear envelope (NE) structure and induced chromosome condensation at an early time point. In contrast, a low concentration of DIM induced autophagy but did not disrupt NE structure. The mutant defective in autophagy was more sensitive to a low concentration of DIM, demonstrating that the autophagic pathway contributes to the survival of cells against DIM. Moreover, our results showed that the lem2 mutant is more sensitive to DIM. NE in the lem2 mutant was disrupted even at the low concentration of DIM. Our results demonstrate that the autophagic pathway and NE integrity are important to maintain viability in the presence of a low concentration of DIM. The mechanism of apoptosis and autophagy induction by DIM might be conserved in fission yeast and humans. Further studies will contribute to the understanding of the mechanism of apoptosis and autophagy by DIM in fission yeast and humans.

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8

Golubev, W. I. "Mycocinogeny in fission yeast." Микология и фитопатология 54, no. 2 (2020): 150–52. http://dx.doi.org/10.31857/s002636482002004x.

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9

Nielsen, Olaf. "Fission yeast goes synthetic." Nature Methods 4, no. 10 (October 2007): 777–78. http://dx.doi.org/10.1038/nmeth1007-777.

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10

Millar, Jonathan. "Recognition for fission yeast." Trends in Cell Biology 10, no. 2 (February 2000): 81–82. http://dx.doi.org/10.1016/s0962-8924(99)01702-x.

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11

Solomon, Mark, Robert Booher, Marc Kirschner, and David Beach. "Cyclin in fission yeast." Cell 54, no. 6 (September 1988): 738–40. http://dx.doi.org/10.1016/s0092-8674(88)90933-6.

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12

Piombo, Sabrina, Gode B. Calleja, Bong Yul Yoo, and Byron F. Johnson. "Ruptured fission yeast walls." Cell Biochemistry and Biophysics 29, no. 3 (October 1998): 263–79. http://dx.doi.org/10.1007/bf02737898.

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13

Johnson, Byron F., Bong Yul Yoo, and Gode B. Calleja. "Smashed fission yeast walls." Cell Biophysics 26, no. 1 (February 1995): 57–75. http://dx.doi.org/10.1007/bf02820887.

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14

TANG, Zhaohua, Norbert F. KÄUFER, and Ren-Jang LIN. "Interactions between two fission yeast serine/arginine-rich proteins and their modulation by phosphorylation." Biochemical Journal 368, no. 2 (December 1, 2002): 527–34. http://dx.doi.org/10.1042/bj20021133.

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The unexpected low number of genes in the human genome has triggered increasing attention to alternative pre-mRNA splicing, and serine/arginine-rich (SR) proteins have been correlated with the complex alternative splicing that is a characteristic of metazoans. SR proteins interact with RNA and splicing protein factors, and they also undergo reversible phosphorylation, thereby regulating constitutive and alternative splicing in mammals and Drosophila. However, it is not clear whether the features of SR proteins and alternative splicing are present in simple and genetically tractable organisms, such as yeasts. In the present study, we show that the SR-like proteins Srp1 and Srp2, found in the fission yeast Schizosaccharomyces pombe, interact with each other and the interaction is modulated by protein phosphorylation. By using Srp1 as bait in a yeast two-hybrid analysis, we specifically isolated Srp2 from a random screen. This Srp interaction was confirmed by a glutathione-S-transferase pull-down assay. We also found that the Srp1—Srp2 complex was phosphorylated at a reduced efficiency by a fission yeast SR-specific kinase, Dis1-suppression kinase (Dsk1). Conversely, Dsk1-mediated phosphorylation inhibited the formation of the Srp complex. These findings offer the first example in fission yeast for interactions between SR-related proteins and the modulation of the interactions by specific protein phosphorylation, suggesting that a mammalian-like SR protein function may exist in fission yeast.

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15

Lim, Hye-Won, Su-Jung Kim, Eun-Hee Park, and Chang-Jin Lim. "Overexpression of a metacaspase gene stimulates cell growth and stress response inSchizosaccharomyces pombe." Canadian Journal of Microbiology 53, no. 8 (August 2007): 1016–23. http://dx.doi.org/10.1139/w07-067.

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A unique gene named pca1+, encoding a metacaspase, was cloned from the fission yeast Schizosaccharomyces pombe and was used to create a recombinant plasmid, pPMC. The metacaspase mRNA level was markedly elevated in the fission yeast cells harboring the plasmid pPMC. Overexpressed Pca1+appeared to stimulate the growth of the fission yeast cells instead of arresting their growth. Its expression was enhanced by stress-inducing agents such as H2O2, sodium nitroprusside, and CdCl2, and it conferred cytoprotection, especially against CdCl2. However, such protection was not reproducible in the budding yeast Saccharomyces cerevisiae harboring pPMC. Taken together, these results propose that Pca1+may be involved in the growth and stress response of the fission yeast.

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16

MacKenzie, Anne M., and Soni Lacefield. "CDK Regulation of Meiosis: Lessons from S. cerevisiae and S. pombe." Genes 11, no. 7 (June 29, 2020): 723. http://dx.doi.org/10.3390/genes11070723.

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Meiotic progression requires precise orchestration, such that one round of DNA replication is followed by two meiotic divisions. The order and timing of meiotic events is controlled through the modulation of the phosphorylation state of proteins. Key components of this phospho-regulatory system include cyclin-dependent kinase (CDK) and its cyclin regulatory subunits. Over the past two decades, studies in budding and fission yeast have greatly informed our understanding of the role of CDK in meiotic regulation. In this review, we provide an overview of how CDK controls meiotic events in both budding and fission yeast. We discuss mechanisms of CDK regulation through post-translational modifications and changes in the levels of cyclins. Finally, we highlight the similarities and differences in CDK regulation between the two yeast species. Since CDK and many meiotic regulators are highly conserved, the findings in budding and fission yeasts have revealed conserved mechanisms of meiotic regulation among eukaryotes.

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17

Houchens, Christopher R., Audrey Perreault, François Bachand, and Thomas J. Kelly. "Schizosaccharomyces pombe Noc3 Is Essential for Ribosome Biogenesis and Cell Division but Not DNA Replication." Eukaryotic Cell 7, no. 9 (July 7, 2008): 1433–40. http://dx.doi.org/10.1128/ec.00119-08.

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ABSTRACT The initiation of eukaryotic DNA replication is preceded by the assembly of prereplication complexes (pre-RCs) at chromosomal origins of DNA replication. Pre-RC assembly requires the essential DNA replication proteins ORC, Cdc6, and Cdt1 to load the MCM DNA helicase onto chromatin. Saccharomyces cerevisiae Noc3 (ScNoc3), an evolutionarily conserved protein originally implicated in 60S ribosomal subunit trafficking, has been proposed to be an essential regulator of DNA replication that plays a direct role during pre-RC formation in budding yeast. We have cloned Schizosaccharomyces pombe noc3 + (Spnoc3 +), the S. pombe homolog of the budding yeast ScNOC3 gene, and functionally characterized the requirement for the SpNoc3 protein during ribosome biogenesis, cell cycle progression, and DNA replication in fission yeast. We showed that fission yeast SpNoc3 is a functional homolog of budding yeast ScNoc3 that is essential for cell viability and ribosome biogenesis. We also showed that SpNoc3 is required for the normal completion of cell division in fission yeast. However, in contrast to the proposal that ScNoc3 plays an essential role during DNA replication in budding yeast, we demonstrated that fission yeast cells do enter and complete S phase in the absence of SpNoc3, suggesting that SpNoc3 is not essential for DNA replication in fission yeast.

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18

Kim, Soo-Mi, and Joel A. Huberman. "Multiple Orientation-Dependent, Synergistically Interacting, Similar Domains in the Ribosomal DNA Replication Origin of the Fission Yeast, Schizosaccharomyces pombe." Molecular and Cellular Biology 18, no. 12 (December 1, 1998): 7294–303. http://dx.doi.org/10.1128/mcb.18.12.7294.

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ABSTRACT Previous investigations have shown that the fission yeast,Schizosaccharomyces pombe, has DNA replication origins (500 to 1500 bp) that are larger than those in the budding yeast,Saccharomyces cerevisiae (100 to 150 bp). Deletion and linker substitution analyses of two fission yeast origins revealed that they contain multiple important regions with AT-rich asymmetric (abundant A residues in one strand and T residues in the complementary strand) sequence motifs. In this work we present the characterization of a third fission yeast replication origin, ars3001, which is relatively small (∼570 bp) and responsible for replication of ribosomal DNA. Like previously studied fission yeast origins,ars3001 contains multiple important regions. The three most important of these regions resemble each other in several ways: each region is essential for origin function and is at least partially orientation dependent, each region contains similar clusters of A+T-rich asymmetric sequences, and the regions can partially substitute for each other. These observations suggest that ars3001function requires synergistic interactions between domains binding similar proteins. It is likely that this requirement extends to other fission yeast origins, explaining why such origins are larger than those of budding yeast.

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19

Crane, Richard, Randa Craig, Rachael Murray, Isabelle Dunand-Sauthier, Tim Humphrey, and Chris Norbury. "A Fission Yeast Homolog of Int-6, the Mammalian Oncoprotein and eIF3 Subunit, Induces Drug Resistance when Overexpressed." Molecular Biology of the Cell 11, no. 11 (November 2000): 3993–4003. http://dx.doi.org/10.1091/mbc.11.11.3993.

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Through a screen to identify genes that induce multi-drug resistance when overexpressed, we have identified a fission yeast homolog of Int-6, a component of the human translation initiation factor eIF3. Disruption of the murine Int-6gene by mouse mammary tumor virus (MMTV) has been implicated previously in tumorigenesis, although the underlying mechanism is not yet understood. Fission yeast Int6 was shown to interact with other presumptive components of eIF3 in vivo, and was present in size fractions consistent with its incorporation into a 43S translation preinitiation complex. Drug resistance induced by Int6 overexpression was dependent on the AP-1 transcription factor Pap1, and was associated with increased abundance of Pap1-responsive mRNAs, but not with Pap1 relocalization. Fission yeast cells lacking the int6gene grew slowly. This growth retardation could be corrected by the expression of full length Int6 of fission yeast or human origin, or by a C-terminal fragment of the fission yeast protein that also conferred drug resistance, but not by truncated human Int-6 proteins corresponding to the predicted products of MMTV-disrupted murine alleles. Studies in fission yeast may therefore help to explain the ways in which Int-6 function can be perturbed during MMTV-induced mammary tumorigenesis.

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20

Fiske, Michael, Stephanie Valtierra, Keith Solvang, Michael Zorniak, Michael White, Sara Herrera, Alina Konnikova, Rebecca Brezinsky, and Shubhik DebBurman. "Contribution of Alanine-76 and Serine Phosphorylation inα-Synuclein Membrane Association and Aggregation in Yeasts." Parkinson's Disease 2011 (2011): 1–12. http://dx.doi.org/10.4061/2011/392180.

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In Parkinson's disease (PD), misfolded and aggregatedα-synuclein protein accumulates in degenerating midbrain dopaminergic neurons. The amino acid alanine-76 inα-synuclein and phosphorylation at serine-87 and serine-129 are thought to regulate its aggregation and toxicity. However, their exact contributions toα-synuclein membrane association are less clear. We found thatα-synuclein is indeed phosphorylated in fission yeast and budding yeast, the two models that we employed for assessingα-synuclein aggregation and membrane association properties, respectively. Surprisingly, blocking serine phosphorylation (S87A, S129A, and S87A/S129A) or mimicking it (S87D, S129D) alteredα-synuclein aggregation in fission yeast. Either blocking or mimicking this phosphorylation increased endomembrane association in fission yeast, but only mimicking it decreased plasma membrane association in budding yeast. Polar substitution mutations of alanine-76 (A76E and A76R) decreasedα-synuclein membrane association in budding yeast and decreased aggregation in fission yeast. These yeast studies extend our understanding of serine phosphorylation and alanine-76 contributions toα-synuclein aggregation and are the first to detail their impact onα-synuclein's plasma membrane and endomembrane association.

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21

Jang, Young Joo, Young Sook Kil, Jee Hee Ahn, Jae Hoon Ji, Jong Seok Lim, M. Won, and Hyang Sook Yoo. "Overexpression Phenotypes of Plk1 and Ndrg2 in Schizosaccharomyces Pombe: Fission Yeast System for Mammalian Gene Study." Key Engineering Materials 277-279 (January 2005): 1–6. http://dx.doi.org/10.4028/www.scientific.net/kem.277-279.1.

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The fission yeast, Schizosaccharomyces pombe is a single-celled free-living fungus that shares many features with cells of more complicated eukaryotes. Many of the genes required for the cell-cycle control, proteolysis, protein modification, and RNA splicing are highly conserved with those of higher eukaryotes. Moreover, fission yeast has the merit of genetics and its genetic system is already well characterized. As such, the current study evaluated the use of a fission yeast system as a tool for the functional study of mammalian genes and attempted to set up an assay system for novel genes. Since the phenotypes of a deletion mutant and the overexpression of a gene are generally analyzed for a functional study of specific genes in yeast, the present study used overexpression phenotypes to study the functions of mammalian genes. Therefore, based on using a thiamine-repressive promoter, two mammalian genes were expressed in fission yeast, and their overexpressed phenotypes compared with those in mammalian cells. The phenotypes resulting from overexpression were analyzed using a FACS, which analyzes the DNA contents, and a microscope. One of the selected genes was the mammalian Polo-like kinase 1 (Plk1), which is activated and plays a role in the mitotic phase of the cell division cycle. The overexpression of various constructs of Plk1 in the HeLa cells caused cell cycle defects, suggesting that the ectopic Plk1s blocked the endogenous Plk1 in the cells. As expected, when the constructs were overexpressed in the fission yeast system, the cells were arrested in mitosis and defected at the end of mitosis. As such, this data suggests that the Plk1-overexpressed phenotypes were similar in the mammalian cells and the fission yeast, thereby enabling the mammalian Plk1 functions to be approximated in the fission yeast. The other selected gene was the N-Myc downstream-regulated gene 2 (ndrg2), which is upregulated during cell differentiation, yet still not well characterized. When the ndrg2 gene was overexpressed in the fission yeast, the cells contained multi-septa. The septa were positioned well, yet their number increased per cell. Therefore, this gene was speculated to block cell division in the last stage of the cell cycle, making the phenotype potentially useful for explaining cell growth and differentiation in mammalian cells. Accordingly, fission yeast is demonstrated to be an appropriate species for the functional study of mammalian genes.

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22

Hagan, I. M. "The fission yeast microtubule cytoskeleton." Journal of Cell Science 111, no. 12 (June 15, 1998): 1603–12. http://dx.doi.org/10.1242/jcs.111.12.1603.

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The Schizosaccharomyces pombe genome sequencing project (http://www.sanger.ac.uk/Projects/S_pombe/) is nearly complete, and this is likely to generate interest in fission yeast as a model system beyond its traditional strongholds in the study of the cell cycle and sexual differentiation. In many fields S. pombe will offer a useful complement to the more widely studied Saccharomyces cerevisiae, but in some areas the impact of S. pombe may well rival or exceed that of this budding yeast in terms of relevance to higher systems. Because of the considerable differences from the S. cerevisiae microtubule cytoskeleton, studying microtubules in S. pombe is likely to enhance the contribution of model systems to our understanding of the principles and practices of microtubule organisation in eukaryotes in general.

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23

., ,. "Centromeric chromatin in fission yeast." Frontiers in Bioscience Volume, no. 13 (2008): 3896. http://dx.doi.org/10.2741/2977.

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24

Rusk, Nicole. "Fission yeast defies the code." Nature Methods 7, no. 4 (April 2010): 255. http://dx.doi.org/10.1038/nmeth0410-254b.

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25

Wilson-Grady, Joshua T., Judit Villén, and Steven P. Gygi. "Phosphoproteome Analysis of Fission Yeast." Journal of Proteome Research 7, no. 3 (March 7, 2008): 1088–97. http://dx.doi.org/10.1021/pr7006335.

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26

Chang, F., and S. G. Martin. "Shaping Fission Yeast with Microtubules." Cold Spring Harbor Perspectives in Biology 1, no. 1 (July 1, 2009): a001347. http://dx.doi.org/10.1101/cshperspect.a001347.

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27

Pasion, Sally. "Fission yeast blooms in Kyoto." Trends in Genetics 18, no. 7 (July 2002): 342–43. http://dx.doi.org/10.1016/s0168-9525(02)02721-x.

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28

Furuya, K. "DNA checkpoints in fission yeast." Journal of Cell Science 116, no. 19 (October 1, 2003): 3847–48. http://dx.doi.org/10.1242/jcs.00790.

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29

McIntosh, J. Richard, Mary K. Morphew, and Thomas H. Giddings. "Electron Microscopy of Fission Yeast." Cold Spring Harbor Protocols 2017, no. 1 (January 2017): pdb.top079822. http://dx.doi.org/10.1101/pdb.top079822.

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30

Pérez, Pilar, and Juan C. Ribas. "Fission Yeast Cell Wall Analysis." Cold Spring Harbor Protocols 2017, no. 11 (July 21, 2017): pdb.top079897. http://dx.doi.org/10.1101/pdb.top079897.

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31

Khodjakov, Alexey, Sabrina La Terra, and Fred Chang. "Laser Microsurgery in Fission Yeast." Current Biology 14, no. 15 (August 2004): 1330–40. http://dx.doi.org/10.1016/j.cub.2004.07.028.

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32

Egel, Richard, Olaf Nielsen, and Dietmar Weilguny. "Sexual differentiation in fission yeast." Trends in Genetics 6 (1990): 369–73. http://dx.doi.org/10.1016/0168-9525(90)90279-f.

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33

Muers, Mary. "Fission yeast compared and contrasted." Nature Reviews Genetics 12, no. 6 (May 4, 2011): 381. http://dx.doi.org/10.1038/nrg3006.

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34

Otsubo, Yoko, and Masayuki Yamamato. "TOR Signaling in Fission Yeast." Critical Reviews in Biochemistry and Molecular Biology 43, no. 4 (January 2008): 277–83. http://dx.doi.org/10.1080/10409230802254911.

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35

OLSON, LAURITZ W., ULLA EDÉN, MICHIKO EGEL-MITANI, and RICHARD EGEL. "Asynaptic meiosis in fission yeast?" Hereditas 89, no. 2 (February 12, 2009): 189–99. http://dx.doi.org/10.1111/j.1601-5223.1978.tb01275.x.

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36

Morphew, Mary K., Thomas H. Giddings, and J. Richard McIntosh. "Cryoelectron Microscopy of Fission Yeast." Cold Spring Harbor Protocols 2017, no. 1 (January 2017): pdb.prot091330. http://dx.doi.org/10.1101/pdb.prot091330.

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37

Pérez, Pilar, Juan C. G. Cortés, Rebeca Martín-García, and Juan C. Ribas. "Overview of fission yeast septation." Cellular Microbiology 18, no. 9 (June 1, 2016): 1201–7. http://dx.doi.org/10.1111/cmi.12611.

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38

Leupold, Urs. "Sex appeal in fission yeast." Current Genetics 12, no. 7 (November 1987): 543–45. http://dx.doi.org/10.1007/bf00419564.

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39

Davey, John. "Fusion of a fission yeast." Yeast 14, no. 16 (December 1998): 1529–66. http://dx.doi.org/10.1002/(sici)1097-0061(199812)14:16<1529::aid-yea357>3.0.co;2-0.

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40

Forsburg, Susan L., and Nicholas Rhind. "Basic methods for fission yeast." Yeast 23, no. 3 (2006): 173–83. http://dx.doi.org/10.1002/yea.1347.

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41

Grewal, Shiv I. S. "Transcriptional silencing in fission yeast." Journal of Cellular Physiology 184, no. 3 (2000): 311–18. http://dx.doi.org/10.1002/1097-4652(200009)184:3<311::aid-jcp4>3.0.co;2-d.

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42

Chaleckis, Romanas, Masahiro Ebe, Tomáš Pluskal, Itsuo Murakami, Hiroshi Kondoh, and Mitsuhiro Yanagida. "Unexpected similarities between theSchizosaccharomycesand human blood metabolomes, and novel human metabolites." Mol. BioSyst. 10, no. 10 (2014): 2538–51. http://dx.doi.org/10.1039/c4mb00346b.

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Comparison of human blood and fission yeast metabolomes revealed that 75% of compounds found in human blood are also detected in fission yeast. Several methylated amino acids are reported as new blood components.

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43

Furuya, Kanji, and Hironori Niki. "The DNA Damage Checkpoint Regulates a Transition between Yeast and Hyphal Growth in Schizosaccharomyces japonicus." Molecular and Cellular Biology 30, no. 12 (March 5, 2010): 2909–17. http://dx.doi.org/10.1128/mcb.00049-10.

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ABSTRACT Dimorphic yeasts change between unicellular growth and filamentous growth. Many dimorphic yeasts species are pathogenic for humans and plants, being infectious as invasive hypha. We have studied the determinants of the dimorphic switch in the nonpathogenic fission yeast Schizosaccharomyces japonicus, which is evolutionarily close to the well-characterized fission yeast S. pombe. We report that camptothecin, an inhibitor of topoisomerase I, reversibly induced the unicellular to hyphal transition in S. japonicus at low concentrations of camptothecin that did not induce checkpoint arrest and the transition required the DNA checkpoint kinase Chk1. Furthermore, a mutation of chk1 induced hyphal transition without camptothecin. Thus, we identify a second function for Chk1 distinct from its role in checkpoint arrest. Activation of the switch from single cell bipolar growth to monopolar filamentous growth may assist cells to evade the source of DNA damage.

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44

Nurse, Paul. "Fission yeast cell cycle mutants and the logic of eukaryotic cell cycle control." Molecular Biology of the Cell 31, no. 26 (December 15, 2020): 2871–73. http://dx.doi.org/10.1091/mbc.e20-10-0623.

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Cell cycle mutants in the budding and fission yeasts have played critical roles in working out how the eukaryotic cell cycle operates and is controlled. The starting point was Lee Hartwell’s 1970s landmark papers describing the first cell division cycle (CDC) mutants in budding yeast. These mutants were blocked at different cell cycle stages and so were unable to complete the cell cycle, thus defining genes necessary for successful cell division. Inspired by Hartwell’s work, I isolated CDC mutants in the very distantly related fission yeast. This started a program of searches for mutants in fission yeast that revealed a range of phenotypes informative about eukaryotic cell cycle control. These included mutants defining genes that were rate-limiting for the onset of mitosis and of the S-phase, that were responsible for there being only one S-phase in each cell cycle, and that ensured that mitosis only took place when S-phase was properly completed. This is a brief account of the discovery of these mutants and how they led to the identification of cyclin-dependent kinases as core to these cell cycle controls.

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Mukaiyama, Hiroyuki, Shiro Kajiwara, Akira Hosomi, Yuko Giga-Hama, Naotaka Tanaka, Taro Nakamura, and Kaoru Takegawa. "Autophagy-deficient Schizosaccharomyces pombe mutants undergo partial sporulation during nitrogen starvation." Microbiology 155, no. 12 (December 1, 2009): 3816–26. http://dx.doi.org/10.1099/mic.0.034389-0.

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Autophagy is triggered when organisms sense radical environmental changes, including nutritional starvation. During autophagy, cytoplasmic components, including organelles, are enclosed within autophagosomes and are degraded upon lysosome–vacuole fusion. In this study, we show that processing of GFP-tagged Atg8 can serve as a marker for autophagy in the fission yeast Schizosaccharomyces pombe. Using this marker, 13 Atg homologues were also found to be required for autophagy in fission yeast. In budding yeast, autophagy-deficient mutants are known to be sterile, whereas in fission yeast we found that up to 30 % of autophagy-defective cells with amino acid auxotrophy were able to recover sporulation when an excess of required amino acids was supplied. Furthermore, we found that approximately 15 % of the autophagy-defective cells were also able to sporulate when a prototrophic strain was subjected to nitrogen starvation, which suggested that fission yeast may store sufficient intracellular nitrogen to allow partial sporulation under nitrogen-limiting conditions, although the majority of the nitrogen source is supplied by autophagy. Monitoring of the sporulation process revealed that the process was blocked non-specifically at various stages in the atg1Δ and atg12Δ mutants, possibly due to a shortage of amino acids. Taking advantage of this partial sporulation ability of fission yeast, we sought evidence for the existence of a recycling system for nitrogen sources during starvation.

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Lu, Jia, and Thomas D. Pollard. "Profilin Binding to Poly-l-Proline and Actin Monomers along with Ability to Catalyze Actin Nucleotide Exchange Is Required for Viability of Fission Yeast." Molecular Biology of the Cell 12, no. 4 (April 2001): 1161–75. http://dx.doi.org/10.1091/mbc.12.4.1161.

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We tested the ability of 87 profilin point mutations to complement temperature-sensitive and null mutations of the single profilin gene of the fission yeast Schizosaccharomyces pombe. We compared the biochemical properties of 13 stable noncomplementing profilins with an equal number of complementing profilin mutants. A large quantitative database revealed the following: 1) in a profilin null background fission yeast grow normally with profilin mutations having >10% of wild-type affinity for actin or poly-l-proline, but lower affinity for either ligand is incompatible with life; 2) in thecdc3-124 profilin ts background, fission yeast function with profilin having only 2–5% wild-type affinity for actin or poly-l-proline; and 3) special mutations show that the ability of profilin to catalyze nucleotide exchange by actin is an essential function. Thus, poly-l-proline binding, actin binding, and actin nucleotide exchange are each independent requirements for profilin function in fission yeast.

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Walker, Sara Imari, Hyunju Kim, and Paul C. W. Davies. "The informational architecture of the cell." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 374, no. 2063 (March 13, 2016): 20150057. http://dx.doi.org/10.1098/rsta.2015.0057.

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We compare the informational architecture of biological and random networks to identify informational features that may distinguish biological networks from random. The study presented here focuses on the Boolean network model for regulation of the cell cycle of the fission yeast Schizosaccharomyces pombe . We compare calculated values of local and global information measures for the fission yeast cell cycle to the same measures as applied to two different classes of random networks: Erdös–Rényi and scale-free. We report patterns in local information processing and storage that do indeed distinguish biological from random, associated with control nodes that regulate the function of the fission yeast cell-cycle network. Conversely, we find that integrated information, which serves as a global measure of ‘emergent’ information processing, does not differ from random for the case presented. We discuss implications for our understanding of the informational architecture of the fission yeast cell-cycle network in particular, and more generally for illuminating any distinctive physics that may be operative in life.

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Koh, Eun-Jin, and Jin Ho Yoon. "Effects of fission yeast ortholog of THOC5 on growth and mRNA export in fission yeast." Korean Journal of Microbiology 51, no. 4 (December 31, 2015): 435–39. http://dx.doi.org/10.7845/kjm.2015.5058.

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Asakawa, Haruhiko, Takaharu G. Yamamoto, and Yasushi Hiraoka. "Fission yeast meets a legend in Kobe: report of the Eighth International Fission Yeast Meeting." Genes to Cells 20, no. 12 (October 19, 2015): 967–71. http://dx.doi.org/10.1111/gtc.12307.

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Chen, Dongrong, W. Mark Toone, Juan Mata, Rachel Lyne, Gavin Burns, Katja Kivinen, Alvis Brazma, Nic Jones, and Jürg Bähler. "Global Transcriptional Responses of Fission Yeast to Environmental Stress." Molecular Biology of the Cell 14, no. 1 (January 2003): 214–29. http://dx.doi.org/10.1091/mbc.e02-08-0499.

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We explored transcriptional responses of the fission yeastSchizosaccharomyces pombe to various environmental stresses. DNA microarrays were used to characterize changes in expression profiles of all known and predicted genes in response to five stress conditions: oxidative stress caused by hydrogen peroxide, heavy metal stress caused by cadmium, heat shock caused by temperature increase to 39°C, osmotic stress caused by sorbitol, and DNA damage caused by the alkylating agent methylmethane sulfonate. We define a core environmental stress response (CESR) common to all, or most, stresses. There was a substantial overlap between CESR genes of fission yeast and the genes of budding yeast that are stereotypically regulated during stress. CESR genes were controlled primarily by the stress-activated mitogen-activated protein kinase Sty1p and the transcription factor Atf1p. S. pombe also activated gene expression programs more specialized for a given stress or a subset of stresses. In general, these “stress-specific” responses were less dependent on the Sty1p mitogen-activated protein kinase pathway and may involve specific regulatory factors. Promoter motifs associated with some of the groups of coregulated genes were identified. We compare and contrast global regulation of stress genes in fission and budding yeasts and discuss evolutionary implications.

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