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Journal articles on the topic 'FISH, LYMPHOMA'

Author: Grafiati

Published: 14 March 2023

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1

Meloni-Ehrig, Aurelia, Christine A. Curtis, Sean P. Mahoney, et al. "Significance of Conventional Cytogenetics in Improving the Diagnosis and Prognosis of Lymphoid Neoplasms in Tissue Samples." Blood 126, no. 23 (2015): 5033. http://dx.doi.org/10.1182/blood.v126.23.5033.5033.

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Abstract Cytogenetic analysis is invaluable for the detection of chromosome abnormalities in tumor samples and is the "gold standard" technique (unique in providing a complete overview of the chromosome complement). Cytogenetic studies of lymph node specimens (LN) can be challenging due to progressively smaller biopsies being procured, low viability, and low proliferative rates. Typically, the initial laboratory evaluation of LN includes flow cytometry and/or immunohistochemistry. Due to overlapping immunophenotypic and morphologic features of some lymphomas, these studies can be insufficient

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2

O’Neill, John Patrick, Fiona Quinn, Anita Dowling, et al. "Composite t(14;18)-Negative Follicular Lymphoma and Nodular Lymphocyte-Predominant Hodgkin Lymphoma." Case Reports in Hematology 2018 (August 2, 2018): 1–4. http://dx.doi.org/10.1155/2018/4312594.

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A composite lymphoma is the rare simultaneous occurrence of two or more distinct lymphomas within a single tissue or organ. Herein, we describe a case of a 51-year-old man presenting with a history of lower limb rash, fatigue, and bulky abdominopelvic lymphadenopathy. An excisional left iliac lymph node biopsy was notable for the composite presence of two distinct lymphoid neoplasms, nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), and follicular lymphoma (FL). Multiplex PCR and FISH analyses failed to demonstrate a t(14;18)(q32;q21) translocation in either composite lymphoma component

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3

Streubel, Berthold, Andrea Lamprecht, Judith Dierlamm, et al. "T(14;18)(q32;q21) involving IGH andMALT1 is a frequent chromosomal aberration in MALT lymphoma." Blood 101, no. 6 (2003): 2335–39. http://dx.doi.org/10.1182/blood-2002-09-2963.

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T(11;18)(q21;q21) is the most common structural abnormality in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) leading to the fusion of the apoptosis inhibitor-2 (API2) gene and the MALT lymphoma-associated translocation (MALT1) gene. In 2 patients with MALT lymphoma of the liver and skin, respectively, t(14;18)(q32;q21) was observed by cytogenetic analysis. Subsequent fluorescence in situ hybridization (FISH) studies disclosed that the immunoglobulin heavy-chain locus (IGH) and the MALT1 gene were rearranged by this translocation. In order to scre

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4

Zhang, John, David Chin, Adam Anthony, et al. "CD5 and CD23 Positive Mantle Cell Lymphoma Detected by Flow Cytometry and Confirmed by FISH Study t(11;14)." Blood 104, no. 11 (2004): 4814. http://dx.doi.org/10.1182/blood.v104.11.4814.4814.

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Abstract The differential diagnoses of CD5 positive B-cell lymphoproliferative disorders mainly include chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and mantle cell lymphoma. Occasionally large cell and marginal zone lymphomas may also be CD5 positive. An accurate diagnosis effects patient management. The classical immunophenotype for chronic lymphocytic leukemia/small lymphocytic lymphoma is CD19/CD5/CD23 positive FMC-7 negative cells with dim CD20 and dim light chain expressions, while mantle cell lymphoma is CD19/CD5/FMC-7 positive with bright CD20 and bright light chai

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5

O'Connor, Sheila J. M., Kathryn Turner, Catherine H. Burton, and Andrew Jack. "Detection of BCL2 Gene Rearrangements in the Reed-Sternberg Cells of Composite Lymphomas or Newly Diagnosed Hodgkin Lymphoma in Patients with a Previous Diagnosis of Follicular Lymphoma." Blood 124, no. 21 (2014): 137. http://dx.doi.org/10.1182/blood.v124.21.137.137.

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Abstract Introduction: Composite lymphomas involving Hodgkin lymphoma (HL) and non-Hodgkin lymphomas (CLL, DLBCL, FL, MZL, MCL, T-NHL) are relatively rare but are increasingly frequently diagnosed. This may be a function of the change in diagnostic practice, the more varied and increased treatment of the presenting disease or simply reflect better monitoring post treatment with re-biopsy of lymph nodes. Composite lymphoma is defined as the synchronous and metachronous development of two or more lymphomas in the same patient. The mechanism of pathogenesis underlying its occurrence is not clearl

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6

Safley, Anne M., Patrick J. Buckley, Andrew J. Creager, et al. "The Value of Fluorescence In Situ Hybridization and Polymerase Chain Reaction in the Diagnosis of B-Cell Non-Hodgkin Lymphoma by Fine-Needle Aspiration." Archives of Pathology & Laboratory Medicine 128, no. 12 (2004): 1395–403. http://dx.doi.org/10.5858/2004-128-1395-tvofis.

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Abstract Context.—Molecular genetic analyses have been predicted to improve the diagnostic accuracy of fine-needle aspiration of B-cell non-Hodgkin lymphoma. Objective.—To determine the value of routine molecular genetic assays, polymerase chain reaction (PCR) and fluorescence in situ hybridization (FISH), in the diagnosis of B-cell non-Hodgkin lymphoma by fine-needle aspiration (FNA). Design.—A multiparametric method, including cytology, flow cytometry, PCR, and FISH, was prospectively evaluated in the diagnosis of B-cell non-Hodgkin lymphoma by FNA. Aspirates from 30 consecutive patients wit

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7

Mitter, Navnit S., Stephen Lanno, Jason Blackson, Michelle Donskoy, and Ralph Ehrenpreis. "Development of a Reflex FISH Assay Panel for Lymphoid Neoplasms Resulted Negative by Cytogenetics and Current FISH Panel and Positive by Hematopathology." Blood 114, no. 22 (2009): 4722. http://dx.doi.org/10.1182/blood.v114.22.4722.4722.

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Abstract Abstract 4722 Fluorescence in situ hybridization (FISH) panel for detecting lymphoid neoplasms in interphase nuclei currently used at most of the laboratories initially utilizes the IGH (14q32.3) locus specific probe and based on negative or positive results obtained, additional testing is done with either the BCL6 (3q27), MYC (8q24) and MALT1 (18q21) locus specific probes, or the MYC/IGH (8q24/14q32.3), CCND1/IGH (11q13/14q32.3) and IGH/BCL2 (14q32.3/18q22) locus specific probes, respectively. Although these probes detect a large number of lymphoma-related abnormalities, approximatel

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8

Verghese, Cherian, Weihong Li, Nanuli Gvazava, et al. "IGH/BCL2 Status Better Predicts Clinico-Pathological Behavior in Primary Splenic Follicular Lymphoma than Histological Grade and Other Molecular Markers." Clinical Pathology 15 (January 2022): 2632010X2211292. http://dx.doi.org/10.1177/2632010x221129242.

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Splenic lymphoma may be primary or secondary. Primary splenic lymphoma’s are rare and usually of follicular cell origin representing <1% of Non-Hodgkin’s Lymphoma’s. Most are secondary with 35% representing Marginal Cell sub-type with the rest being Diffuse Large B-Cell Lymphoma’s. Unlike the uniformly aggressive clinical course of Diffuse Large B-Cell Lymphoma’s, biological behavior of Primary Splenic CD10-Positive Small B-Cell Lymphoma/Follicular Lymphoma remains less well defined. We present here a solitary splenic mass confirmed as Primary Splenic CD10-Positive Small B-Cell Lymphoma/Fol

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9

Dierlamm, Judith, Mathijs Baens, Margarita Stefanova-Ouzounova, et al. "Detection of t(11;18)(q21;q21) by interphase fluorescence in situ hybridization using API2 and MLTspecific probes." Blood 96, no. 6 (2000): 2215–18. http://dx.doi.org/10.1182/blood.v96.6.2215.

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Abstract The translocation of chromosome 11, long arm, region 2, band 1, to chromosome 18, long arm, region 2, band 1 (t(11;18)(q21;q21)) represents a recurrent chromosomal abnormality in extranodal marginal zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue (MALT) type and leads to a fusion of the apoptosis inhibitor-2 (API2) gene on chromosome 11 and the MALT lymphoma-associated translocation (MLT) gene on chromosome 18. A 2-color fluorescence in situ hybridization (FISH) assay, which can be used for the detection of t(11;18) in interphase nuclei and metaphase chromosomes on f

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10

Dierlamm, Judith, Mathijs Baens, Margarita Stefanova-Ouzounova, et al. "Detection of t(11;18)(q21;q21) by interphase fluorescence in situ hybridization using API2 and MLTspecific probes." Blood 96, no. 6 (2000): 2215–18. http://dx.doi.org/10.1182/blood.v96.6.2215.h8002215_2215_2218.

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The translocation of chromosome 11, long arm, region 2, band 1, to chromosome 18, long arm, region 2, band 1 (t(11;18)(q21;q21)) represents a recurrent chromosomal abnormality in extranodal marginal zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue (MALT) type and leads to a fusion of the apoptosis inhibitor-2 (API2) gene on chromosome 11 and the MALT lymphoma-associated translocation (MLT) gene on chromosome 18. A 2-color fluorescence in situ hybridization (FISH) assay, which can be used for the detection of t(11;18) in interphase nuclei and metaphase chromosomes on fresh and

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11

Buño, Ismael, Paola Nava, Angela Alvarez-Doval, et al. "Lymphoma Associated Chromosomal Abnormalities Can Be Easily Detected by FISH on Tissue Imprints. an Underused Diagnostic Alternative." Blood 104, no. 11 (2004): 4270. http://dx.doi.org/10.1182/blood.v104.11.4270.4270.

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Abstract Detection of specific chromosomal abnormalities is essential in the diagnosis of several lympholiferative disorders. However, conventional cytogenetic studies are not frequently carried out from biopsies as it is in bone marrow (BM) specimens. On the contrary, FISH is usually performed on paraffin embedded tissue, an alternative with potential technical nuances both in its application and its interpretation. In our experience, FISH on tissue imprints is the ideal alternative to overcome these problems. In the present study, 46 tissue imprints and 17 BM smears from 43 patients with lym

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12

Troen, Gunhild, Iwona Wlodarska, Abdirashid Warsame, Silvia H. Llodrà, Christiane De Wolf-Peeters, and Jan Delabie. "NOTCH2 Mutations in Marginal Zone Lymphoma." Blood 108, no. 11 (2006): 2426. http://dx.doi.org/10.1182/blood.v108.11.2426.2426.

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Abstract Notch2 is a membrane receptor and transcription factor that is indispensable for marginal zone cell differentiation. Also, marginal zone cell lymphomas express increased levels of Notch2 when compared with other B-cell lymphomas. Of interest, activating mutations have previously been described for Notch1, a homologous transcription factor which is important for T-cell differentiation, in up to 50% of cases of acute T-lymphoblastic leukemia, and are thought to contribute to leukemogenesis. We therefore investigated whether activating mutations in the NOTCH2 gene could be identified, es

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13

Yamashita, Saori, Yayoi Matsuda, Hiroki Muta, et al. "Sarcoidosis-Lymphoma Syndrome Associated With Primary Thyroid Lymphoma: A Case Report." Journal of the Endocrine Society 5, Supplement_1 (2021): A900. http://dx.doi.org/10.1210/jendso/bvab048.1837.

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Abstract Background: Sarcoidosis is occasionally accompanied by hematologic malignancies, including lymphoma, called sarcoidosis-lymphoma syndrome. Although the mechanism underlying the induction of lymphomas is still unknown, understanding the immunological background of sarcoidosis could help explain the possible mechanisms of the induction of lymphomas. Case Presentation: A 52-year-old woman was diagnosed chronic thyroiditis with normal thyroid function. One year later, she underwent a screening chest radiograph and identified bilateral hilar adenopathy and mediastinum lymphadenopathy. Subs

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14

Ferti, Angeliki D., Anna D. Panani, Maria I. Stamouli, Dimitra P. Rondogianni, Sotirios A. Raptis, and Bryan D. Young. "M-FISH in gastric lymphoma." Cancer Genetics and Cytogenetics 155, no. 1 (2004): 63–66. http://dx.doi.org/10.1016/j.cancergencyto.2004.02.015.

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15

Gascoyne, Randy D. "Hematopathology Approaches to Diagnosis and Prognosis of Indolent B-Cell Lymphomas." Hematology 2005, no. 1 (2005): 299–306. http://dx.doi.org/10.1182/asheducation-2005.1.299.

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Abstract The advent of new technologies has contributed to improvements in the diagnosis and classification of the non-Hodgkin lymphomas (NHL). Use of a more extensive test menu of paraffin active monoclonal antibodies for immunohistochemistry, molecular cytogenetic studies including standard cytogenetics, multi-color fluorescence in-situ hybridization (FISH), polymerase chain reaction and locus-specific FISH, as well as developments in high-resolution techniques including microarray gene expression profiling and array comparative genomic hybridization (CGH) allow more accurate diagnosis and p

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16

Sesques, Pierre, and Nathalie A. Johnson. "Approach to the diagnosis and treatment of high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements." Blood 129, no. 3 (2017): 280–88. http://dx.doi.org/10.1182/blood-2016-02-636316.

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Abstract High-grade B-cell lymphomas (HGBLs) with MYC and BCL2 and/or BCL6 rearrangements, so-called “double-hit” lymphomas (HGBL-DH), are aggressive lymphomas that form a separate provisional entity in the 2016 revised World Health Organization Classification of Lymphoid Tumors. Fluorescence in situ hybridization (FISH) will be required to identify HGBL-DH and will reclassify a subset of diffuse large B-cell lymphomas (DLBCLs) and HGBLs with features intermediate between DLBCL and Burkitt lymphoma into this new category. Identifying patients with HGBL-DH is important because it may change cli

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17

Sun, Guoxian, Lya Montella, and Min Yang. "MYC Gene FISH Testing in Aggressive B-Cell Lymphomas: Atypical Rearrangements May Result in Underreporting of Positive Cases." Blood 120, no. 21 (2012): 1552. http://dx.doi.org/10.1182/blood.v120.21.1552.1552.

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Abstract Abstract 1552 Background: Multifunctional MYC oncogene overexpression resulting from genomic rearrangement plays a critical role in lymphomagenesis and lymphoma manifestation, particularly in aggressive B-cell lymphomas such as Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL) and B-cell lymphoma unclassifiable with features intermediate between DLBCL and BL including double hit or triple hit lymphomas (DHL/THL). Accurate detection of MYC gene rearrangement, its presence or absence, has become increasingly important with its diagnostic and consequent therapeutic implication

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18

Alrajjal, Ahmed, Moumita Choudhury, Jay Yang, and Ali Gabali. "Cell-blocks and hematolymphoid lesions." Cytojournal 18 (March 31, 2021): 7. http://dx.doi.org/10.25259/cytojournal_10_2021.

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Cell-blocks are an important component for evaluation for hematolymphoid lesions. They are especially critical for immunocharacterization of the lymphoid population especially when flow cytometry is not available or cannot be performed. In addition, cell-blocks allow various molecular pathology tests including gene rearrangement studies and FISH, proteomics analysis, and microbiology/histochemical special stains. Fine-needle aspiration (FNA) for mass lesions, lymphadenopathy, and effusion fluids are common cytopathology specimens which are frequently cell-blocked. The differential diagnosis of

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19

Landsburg, Daniel J., Sunita Dwivedy Nasta, Jakub Svoboda, Jennifer JD Morrissette, and Stephen J. Schuster. "“Double-Hit” Cytogenetic Status Is Not Predicted By Baseline Clinicopathologic Characteristics and Is Highly Associated With Overall Survival In B Cell Lymphoma Patients." Blood 122, no. 21 (2013): 4338. http://dx.doi.org/10.1182/blood.v122.21.4338.4338.

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Abstract Background “Double-Hit” (DH) lymphomas are most commonly defined as B cell lymphomas demonstrating a MYC gene rearrangement and additional rearrangement(s) involving BCL2 and/or BCL6. DH lymphomas respond poorly to standard immunochemotherapy regimens, often prompting the use of more intensive treatments. DH gene rearrangements can be identified through metaphase cytogenetic testing or more sensitive fluorescence in situ hybridization (FISH) on diagnostic tissue specimens, although these studies are not routinely performed. Here, we analyze a cohort of B cell lymphoma patients to dete

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Harris, Nancy Lee, Harald Stein, Sarah E. Coupland, et al. "New Approaches to Lymphoma Diagnosis." Hematology 2001, no. 1 (2001): 194–220. http://dx.doi.org/10.1182/asheducation-2001.1.194.

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Abstract Recent years have brought an explosion of new diagnostic tools to the pathology of lymphomas, which have permitted more precise disease definition and recognition of factors that can predict prognosis and response to treatment. These new methods exploit both the biological features of normal lymphocytes as they progress through differentiation pathways and the genetic abnormalities that characterize malignant transformation. These features can be assessed in individual tumors with techniques that detect proteins (immunophenotyping), messenger RNA (in-situ hybridization), or changes in

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Salaverria, Itziar, Claudia Philipp, Ilske Oschlies, et al. "Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adults." Blood 118, no. 1 (2011): 139–47. http://dx.doi.org/10.1182/blood-2011-01-330795.

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Abstract The prognosis of germinal center–derived B-cell (GCB) lymphomas, including follicular lymphoma and diffuse large-B-cell lymphoma (DLBCL), strongly depends on age. Children have a more favorable outcome than adults. It is not known whether this is because of differences in host characteristics, treatment protocols, or tumor biology, including the presence of chromosomal alterations. By screening for novel IGH translocation partners in pediatric and adult lymphomas, we identified chromosomal translocations juxtaposing the IRF4 oncogene next to one of the immunoglobulin (IG) loci as a no

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22

Di Rocco, Alice, Luigi Petrucci, Giovanni Manfredi Assanto, Maurizio Martelli, and Alessandro Pulsoni. "Extranodal Marginal Zone Lymphoma: Pathogenesis, Diagnosis and Treatment." Cancers 14, no. 7 (2022): 1742. http://dx.doi.org/10.3390/cancers14071742.

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Extranodal Marginal Zone Lymphoma (EMZL lymphoma) is an indolent B-cell lymphoma with a median age at diagnosis of about 60 years. It accounts for 7–8% of all B-cell lymphomas. It can occur in various extranodal sites, including stomach, lung, ocular adnexa, and skin; furthermore, the disseminated disease can be found in 25–50% of cases. Several infectious agents, such as Helicobacter pylori (H. Pylori) in the case of gastric Mucosa Associated Lymphoid Tissue (MALT) Lymphoma, can drive the pathogenesis of this cancer, through the autoantigenic stimulation of T cells, but there may also be othe

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Fukumoto, Kota, Sou Nakaji, Yasuhito Suehara, et al. "Endoscopic Ultrasound-Guided Fine Needle Aspiration Biopsy for Diagnosis of Intra-Abdominal Lymphoma without Accessible Peripheral Lymphadenopathy." Blood 124, no. 21 (2014): 5380. http://dx.doi.org/10.1182/blood.v124.21.5380.5380.

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Abstract Introduction: Endoscopic ultrasound-guided fine needle aspiration biopsy (EUS-FNAB) is considered the procedure of choice for the diagnosis and staging of intra-abdominal non-Hodgkin’s lymphoma (NHL) without accessible peripheral lymphadenopathy. However, diagnosis and subclassification lymphoma by FNAB is often challenging due to variable cellularity and lack of architecture. Recent advances of ancillary techniques such as immunohistochemical staining, flowcytometry (FCM), fluorescence in situ hybridization (FISH) analysis and molecular analysis allowed classify lymphoma more precise

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24

Sun, Guoxian, and Lya Montella. "Oncogene Amplification as an Incidental Finding in FISH Testing for Gene Rearrangements in Lymphoid Hematopoietic Neoplasms." Blood 118, no. 21 (2011): 2505. http://dx.doi.org/10.1182/blood.v118.21.2505.2505.

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Abstract Abstract 2505 Oncogene amplification resulting in overexpression, although common in solid tumors, is rare in hematopoietic neoplasms. This is particularly true in lymphoid neoplasms compared to AML where MYC, MLL or RUNX1 (AML1) amplification has been mostly seen, and to CML where BCR/ABL fusion gene amplification has been also reported. Typically, lymphoid neoplasms are tested at diagnosis by FISH for specific reciprocal chromosome translocations that lead to overexpression of deregulated oncogenes such as BCL1, BCL2, BCL6 and MYC in B-cell lymphoma and myeloma or BCR/ABL gene fusio

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25

Campbell, Neil, Joseph J. Kramer, Katherine Piso, et al. "The Role of ETV6/TEL in Hematopoiesis and Lymphoid Neoplasia." Blood 114, no. 22 (2009): 972. http://dx.doi.org/10.1182/blood.v114.22.972.972.

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Abstract Abstract 972 The transcriptional repressor TEL (Translocation Ets Leukemia) also known as ETV6 (Ets variant gene 6) located on human chromosome 12 is essential for hematopoietic stem cell (HSC) maintenance. Abnormalities involving TEL on the short arm of chromosome 12 including deletions and translocations are common in a surprisingly wide spectrum of hematological and non-hematological malignancies. Genome-wide analysis of leukemic samples revealed the loss of TEL expression and loss of heterozygousity (LOH) in more than half of B-cell ALL patients. We have previously reported on the

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26

Kern, Wolfgang, Torsten Haferlach, Susanne Schnittger, and Claudia Haferlach. "Correlation of Multiparameter Flow Cytometry and Fluorescence In Situ Hybridization in Quantifying Malignant Cells at Low Frequencies in B-Cell Lymphoproliferative Diseases." Blood 110, no. 11 (2007): 4428. http://dx.doi.org/10.1182/blood.v110.11.4428.4428.

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Diagnostic and follow-up evaluation of patients with B-cell lymphoproliferative diseases includes the assessment of peripheral blood and bone marrow samples by both multiparameter flow cytometry (MFC) and fluorescence in situ hybridization (FISH) for the detection and quantification of malignant cells. Depending on the type of aberrant immunophenotype and on the probes applied for FISH sensitivity may vary particularly if small populations of malignant cells are present. We evaluated 61 peripheral blood (n=20) and bone marrow (n=41) samples from patients with B-cell lymphoproliferative disease

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27

Bagg, Adam. "B Cells Behaving Badly: A Better Basis to Behold Belligerence in B-Cell Lymphomas." Hematology 2011, no. 1 (2011): 330–35. http://dx.doi.org/10.1182/asheducation-2011.1.330.

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Abstract A plethora of genetic abnormalities has been described in B-cell lymphomas, some of which arise when physiologic mechanisms involved in the generation of immunologic diversity go awry. Several different lymphoma types, such as follicular lymphoma (FL), mantle cell lymphoma (MCL), and Burkitt lymphoma (BL), are associated with hallmark translocations that occur as a consequence of these errors (t(14;18)(q32;q21), t(11;14)(q13;q32), and t(8;14)(q24;q32), respectively); however, none of these associations is absolute and none is completely diagnostically specific or sensitive. The advant

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28

Miura, Yukiko, Joji Yamamoto, Katsura Kohata, Kenichi Ishizawa, Ryo Ichinohasama, and Hideo Harigae. "Clinicopathological Features of Malignant Lymphoma in JAPAN- Data From the Miyagi Study." Blood 114, no. 22 (2009): 4997. http://dx.doi.org/10.1182/blood.v114.22.4997.4997.

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Abstract Abstract 4997 Background Malignant lymphoma comprises a diverse group of histologic categories. To date, several epidemiological studies in Japan have been reported, however, the data were collected from selected representative institutions, therefore, the results might not reflect the actual incidence and characteristics of malignant lymphoma in Japan. The Miyagi Study is a comprehensive epidemiologic study of malignant lymphoma, including immunologic and genetic information, constructed by a population-based registration system covering Miyagi prefecture, Japan. The population compo

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Coventry, Susan, Hope H. Punnett, Ewa Z. Tomczak та ін. "Consistency of Isochromosome 7q and Trisomy 8 in Hepatosplenic γδ T-cell Lymphoma: Detection by Fluorescence in Situ Hybridization of a Splenic Touch-Preparation from a Pediatric Patient". Pediatric and Developmental Pathology 2, № 5 (1999): 478–83. http://dx.doi.org/10.1007/s100249900152.

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Hepatosplenic gamma-delta (γδ) T-cell lymphoma is a rare but increasingly recognized lymphoid malignancy predominantly affecting young adult males. It is not well appreciated in the pediatric population. We report the third case of this aggressive lymphoma in a child as well as additional support for the consistency of the recently discovered cytogenetic abnormalities, isochromosome 7q and trisomy 8, which in this case were documented using fluorescence in situ hybridization (FISH) of a touch-preparation of the spleen.

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Ye, Hongtao, Liping Gong, Hongxiang Liu, et al. "Strong BCL10 Nuclear Expression Identifies Gastric MALT Lymphomas That Do Not Respond to H. pylori Eradication." Blood 106, no. 11 (2005): 982. http://dx.doi.org/10.1182/blood.v106.11.982.982.

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Abstract Purpose: In a previous retrospective study, we have shown that 75% of gastric MALT lymphomas that did not respond to H. pylori eradication could be identified by detection of t(11;18)(q21;q21). The present study examined the value of t(1;14)(p22;q32) in prediction of the response of gastric MALT lymphomas to H. pylori eradication. Patients and Methods: A total of 111 patients with H. pylori-positive gastric MALT lymphoma, who were treated by H. pylori eradication, were screened for BCL10 involved chromosome translocation by BCL10 immunohistochemistry, followed by interphase FISH and r

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Anand, Shankar, Akshatha C, Libin Babu Cherian, and Ramachandra C. "Ocular Extranodal Marginal Zone Lymphoma - A Study of Twenty-Two Cases Presented at Bangalore, Karnataka." Journal of Evidence Based Medicine and Healthcare 8, no. 24 (2021): 2070–76. http://dx.doi.org/10.18410/jebmh/2021/388.

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BACKGROUND Ocular adnexa lympho-proliferative disorders are a divergent diverse category of ocular malignancies, comprising roughly about 1 % to 2 % of Non-Hodgkin’s lymphomas (NHLs) and 8 % of extranodal lympho-proliferative disorders. The most frequent type, approximating for up to 80 % of cases that constitutes the primary is marginal zone lymphoma of mucosa associated lymphoid tissue (MALT) type. Marginal zone lymphomas which usually have an extranodal presentation are routinely diagnosed by histomorphology by the diffuse infiltration of atypical lymphoid cells with plasmacytoid appearance

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32

Sanders, Lucinda, Sandrine Jayne, Ben Kennedy, et al. "A Double Hit CD10-Negative B-Cell Lymphoma with t(3;8)(q27;q24) Leading to Juxtaposition of theBCL6andMYCLoci Associated with Good Clinical Outcome." Case Reports in Hematology 2014 (2014): 1–5. http://dx.doi.org/10.1155/2014/120714.

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The WHO classification of lymphomas allows for a group of diseases that have features intermediate between those of Burkitt lymphoma and diffuse large B-cell lymphoma. These are a diverse group of diseases whose genetics and clinical course are yet to be fully described. We report an unusual case of high grade B-cell lymphoma, intermediate between DLBCL and BL, lacking CD10 expression in which the chromosomal translocation t(3;8)(q27;q24) was found to be the sole chromosomal abnormality. FISH analysis demonstrated juxtaposition of theBCL6andMYCloci without obvious involvement of theIGHlocus, s

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33

Alizadeh, Ash A., Matthew Anderson, Holbrook E. Kohrt, et al. "Clinical and Pathological Features of Non-Hodgkin Lymphomas Harboring Concurrent t(14;18) and 8q24 Anomalies." Blood 116, no. 21 (2010): 3134. http://dx.doi.org/10.1182/blood.v116.21.3134.3134.

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Abstract Abstract 3134 Background: Concurrent t(14;18) and 8q24 translocations involving BCL2 and MYC in non-Hodgkin lymphomas (NHL) are rare, but are associated with a inferior overall survival (OS) regardless of the presenting or antecedent histological features (Johnson N, et al. Blood 2009). We sought to confirm these observations in an independent cohort of patients with NHL. Methods: Metaphase karyotypes and/or fluorescence in-situ hybridization (FISH) were used to identify cases of NHL with cytogenetic abnormalities involving 18q21 and 8q24 (BCL2 and MYC). Clinical and cytogenetic chara

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Swerdlow, Steven H. "Diagnosis of ‘double hit’ diffuse large B-cell lymphoma and B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma: when and how, FISH versus IHC." Hematology 2014, no. 1 (2014): 90–99. http://dx.doi.org/10.1182/asheducation-2014.1.90.

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Abstract Identification of large B-cell lymphomas that are “extra-aggressive” and may require therapy other than that used for diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS), is of great interest. Large B-cell lymphomas with MYC plus BCL2 and/or BCL6 rearrangements, so-called ‘double hit’ (DHL) or ‘triple hit’ (THL) lymphomas, are one such group of cases often recognized using cytogenetic FISH studies. Whether features such as morphologic classification, BCL2 expression, or type of MYC translocation partner may mitigate the very adverse prognosis of DHL/THL is controversia

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Johansson, Ann-Sofie, Ulrika Norén-Nyström, Åsa Larefalk, Dan Holmberg, and Magnus Lindskog. "Fish oil delays lymphoma progression in theTLLmouse." Leukemia & Lymphoma 51, no. 11 (2010): 2092–97. http://dx.doi.org/10.3109/10428194.2010.522284.

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Wlodarska, Iwona, Peter Vandenberghe, Peet Nooien, Anne Hagemeijer, Peter Marynen, and Chris De Wolf-Peeters. "FOXP1, a Highly Expressed Gene in a Subset of DLBCL, Is Targeted by a Recurrent t(3;14)(p13;q32)." Blood 104, no. 11 (2004): 2891. http://dx.doi.org/10.1182/blood.v104.11.2891.2891.

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Abstract Chromosomal translocations involving the immunoglobulin heavy chain genes cluster (IGH) at 14q32 have been found in up to 70% of B-non Hodgkin’s lymphoma. These aberrations lead to deregulation of putative oncogenes by their juxtaposition with IGH enhancer elements. So far, more than 20 genes affected by t(14q32) have been identified in B-cell malignancies. The most frequently rearranged genes include BCL1/11q13, BCL2/18q21, BCL6/3q27 and CMYC/8q24. We report here a novel t(3;14)(p13;q32) involving IGH, as shown by FISH, in three lymphoma cases. One of these cases was diagnosed as gas

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Felten, Christopher L., Joel A. Chan, Dulce R. DeCastro, Jean Lopategui, and Swapnil P. Rajurkar. "Blastoid Variant Mantle Cell Lymphoma Expressing Aberrant CD3 and CD10 with Concurrent Small Lymphocytic Lymphoma: Establishment of a Clonal Relationship by B- and T-Cell Receptor Gene Rearrangements." Case Reports in Hematology 2018 (December 5, 2018): 1–10. http://dx.doi.org/10.1155/2018/8303571.

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Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin B-cell lymphoma typically expressing CD19, CD20, CD5, FMC-7, CyclinD1, and SOX-11 and harboring the IgH/CCND1 translocation. We report a blastoid variant of mantle cell lymphoma (MCL) involving an inguinal lymph node that, in addition to classical phenotypic and genetic findings, also aberrantly coexpresses surface CD10 and cytoplasmic CD3. Small lymphocytic lymphoma (SLL) was also present in the same lymph node and in the bone marrow. B- and T-cell gene rearrangement studies by PCR show the MCL and SLL to be clonally related. Expression

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Mai, B., A. Berumen, A. Herrmann, and L. Chen. "Discordant Lymphoma: A Sequential Case of Burkitt Lymphoma and Classic Hodgkin Lymphoma." American Journal of Clinical Pathology 154, Supplement_1 (2020): S109—S110. http://dx.doi.org/10.1093/ajcp/aqaa161.239.

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Abstract Casestudy A discordant lymphoma is a rare condition in which two or more subtypes of lymphomas can occur in different anatomic sites; the distinct sub-classifications can present concurrently or sequentially. We present a rare case of a second primary Classic Hodgkin Lymphoma (CHL) several years after achieving remission from an unusual presentation of a non-Hodgkin lymphoma (NHL). Results A 40-year-old HIV-positive male presented to the emergency department for acute cholecystitis. Sections of his gallbladder revealed atypical monomorphic lymphocyte infiltrate that were diffusely pos

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Sun, Guoxian, Min Yang, Lya Montella, and Valentina Mizhiritskaya. "FISH Diagnostics of Double Hit or Triple Hit B-Cell Lymphomas." Blood 120, no. 21 (2012): 1599. http://dx.doi.org/10.1182/blood.v120.21.1599.1599.

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Abstract Abstract 1599 Fluorescence in situ hybridization (FISH) is currently a widely used and most objective technology in identifying double hit or triple hit lymphomas (DHL/THL) that consist of a spectrum of genetically and pathologically heterogeneous B-cell neoplasms. Accurate detection with appropriate FISH probes or panels helps diagnosis, risk stratification and therapy selection, particularly in commonly seen aggressive lymphomas such as Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL) and B-cell lymphoma unclassifiable with features intermediate between DLBCL and BL. We

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Cassidy, Daniel P., Jennifer R. Chapman, Rafael Lopez, et al. "Comparison Between Integrated Genomic DNA/RNA Profiling and Fluorescence In Situ Hybridization in the Detection of MYC, BCL-2, and BCL-6 Gene Rearrangements in Large B-Cell Lymphomas." American Journal of Clinical Pathology 153, no. 3 (2019): 353–59. http://dx.doi.org/10.1093/ajcp/aqz172.

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Abstract Objectives To compare fluorescence in situ hybridization (FISH) and a commercially available sequencing assay for comprehensive genomic profiling (CGP) to determine the best approach to identify gene rearrangements (GRs) in large B-cell lymphomas (LBCLs). Methods Comparison of standard-of-care FISH assays (including a two-probe approach for MYC; break-apart and fusion probes) and an integrated genomic DNA/RNA sequencing CGP approach on a set of 69 consecutive LBCL cases. Results CGP detected GRs, including those involving MYC (1), BCL-2 (3), and BCL-6 (3), not detected by FISH. FISH d

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Penas, Eva Maria Murga, Evelyne Callet-Bauchu, Nadine Albert, et al. "Molecular Characterization of the T(14;18)(q32;q21) Involving the IGH Locus and the MALT1 Gene in MALT Lymphomas." Blood 112, no. 11 (2008): 4145. http://dx.doi.org/10.1182/blood.v112.11.4145.4145.

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Abstract The t(14;18)(q32;q21) involving the MALT1 and IGH genes is a recurrent abnormality in MALT lymphomas. So far, molecular genetic characterization of the t(14;18)/IGHMALT1 has only been performed in 2 cases and revealed a fusion of the entire coding region of MALT1 to the IGH locus. We herein report the molecular genetic analyses of 2 new cases of MALT lymphoma harboring the t(14;18)/IGH-MALT1 using fluorescence in situ hybridization (FISH) and we determined the molecular characteristics at the IGH-MALT1 junctions using long-distance PCR (LD-PCR). The first case, a 71-year-old female, p

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Racke, Frederick, Sabrina Simpson, Beth Christian, Kristie A. Blum, Robert Hasserjian, and Weiqiang Zhao. "Evidence of Long Latency Periods Prior to Development of Mantle Cell Lymphoma." Blood 116, no. 21 (2010): 323. http://dx.doi.org/10.1182/blood.v116.21.323.323.

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Abstract Abstract 323 Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma characterized by treatment failures and short survival. At presentation, MCL is often widely disseminated. Occasionally, early lymphoma can be seen as in situ lesions involving the mantle zones of secondary follicles. The primary genetic lesion involved in the pathogenesis of the disease is the t(11;14)(q13;q32)/(IGH/CCND1) which leads to the overexpression of cyclin D1, a cell cycle regulatory protein that is not normally expressed in B-cells. However, MCL frequently has numerous additional chromosomal alteratio

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Poetsch, M., K. Weber-Matthiesen, H. J. Plendl, W. Grote, and B. Schlegelberger. "Detection of the t(14;18) chromosomal translocation by interphase cytogenetics with yeast-artificial-chromosome probes in follicular lymphoma and nonneoplastic lymphoproliferation." Journal of Clinical Oncology 14, no. 3 (1996): 963–69. http://dx.doi.org/10.1200/jco.1996.14.3.963.

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PURPOSE The aim of this study was to establish a fluorescence in situ hybridization (FISH) technique for the detection of t(14;18)(q32;q21), characteristic for follicular lymphoma (Kiel classification: centroblastic centrocytic [cb-cc] lymphoma). MATERIALS AND METHODS After the FISH system had been established, parallel studies of lymph node biopsy specimens from 30 patients with cb-cc lymphoma and from 32 patients with nonneoplastic lymphoproliferation were performed by means of chromosome analysis, polymerase chain reaction (PCR), and FISH analysis. Two differently labeled yeast-artificial-c

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Sharma, Purva, Sakshi Singal, Patrick Costello, and Koyamangalath Krishnan. "Burkitt lymphoma: interpreting FISH testing for MYC gene rearrangements." BMJ Case Reports 15, no. 2 (2022): e246687. http://dx.doi.org/10.1136/bcr-2021-246687.

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Burkitt lymphoma is a highly aggressive B cell non-Hodgkin’s lymphoma characterised by translocation of MYC gene on chromosome 8. This translocation is usually detected by fluorescent in-situ hybridisation (FISH) studies as part of routine diagnostic work-up and prognostication. FISH testing is commonly done with the break-apart probe (BAP). This case illustrates how this testing can be falsely negative. This patient is a young male diagnosed with Stage I low-risk Burkitt with FISH negative for MYC translocation initially on BAP testing. Additional testing with dual FISH probe detected MYC/IGH

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Woroniecka, Renata, Grzegorz Rymkiewicz, Lukasz M. Szafron, et al. "Cryptic MYC insertions in Burkitt lymphoma: New data and a review of the literature." PLOS ONE 17, no. 2 (2022): e0263980. http://dx.doi.org/10.1371/journal.pone.0263980.

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The occurrence of MYC-negative Burkitt lymphoma (BL) has been discussed for many years. The real frequency of the MYC insertion in MYC-negative BL is still unknown. Fine-needle aspiration biopsies of 108 consecutive patients with clinicopathologically suspected BL (suspBL) were evaluated by flow cytometry, classical cytogenetics, and fluorescence in situ hybridization (FISH). We found 12 cases (11%) without the MYC rearrangement by FISH with a MYC breakapart probe: two patients (1.9%) with cryptic MYC/IGH fusion (finally diagnosed as BL) and 10 patients (9.3%) with 11q gain/loss (finally diagn

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Reddy, Kavita S., Mohammad Ansari-Lari, and Bruce Dipasquale. "Burkitt Transformation of Mantle Cell Lymphoma." Blood 110, no. 11 (2007): 4129. http://dx.doi.org/10.1182/blood.v110.11.4129.4129.

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Abstract MYC rearrangements are not included as a genetic change in the blastoid variants of mantle cell lymphoma (Jaffe, et al (2001) WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC Press.). We present two cases both with CCND1/IGH and MYC rearrangements. Case 1. An 82-year-old male with no known history of lymphoma presented with thrombocytopenia, loss of appetite and “abdominal fullness.” Imaging studies showed enlarged retroperitoneal lymph nodes. The peripheral blood smear had 18,000 WBC with approximately 30% circulating atypical lymphocytes. Flow cytomet

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Jiang, Shi-Ping, Derek Bouman, and Karine Hovanes. "Detection of Genetic Abnormalities for Diffuse Large B-Cell Lymphoma by Selective Interphase Analysis with FISH Method." Blood 112, no. 11 (2008): 4149. http://dx.doi.org/10.1182/blood.v112.11.4149.4149.

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Abstract Diffuse Large B-cell Lymphoma (DLBCL) accounts for approximately 30% of all lymphoid malignancies. It can be difficult to separate DLBCL from Burkitt lymphoma and plasmablastic myeloma by morphology and flow cytometric immunophenotyping alone. Fluorescent in situ hybridization (FISH) targetgene analysis can assist the differential diagnosis by detection of genetic abnormalities associated with DLBCL. Though no consistent numeric chromosomal abnormalities or translocations are observed as a hallmark for DLBCL, most cases have rearranged immunoglobulin heavy chain (IgH), BCL2 and MYC ge

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Wang, Endi, Charles Blake Hutchinson, Qin Huang, Siby Sebastian, and Catherine Rehder. "Transformation of Indolent Small B-Cell Lymphoma to Histiocytic Sarcoma: Report of Two Cases with Molecular/Genetic Evidence of Clonal Relationship Between Two Morphologically and Immunophenotypically Distinctive Neoplasms." Blood 114, no. 22 (2009): 3960. http://dx.doi.org/10.1182/blood.v114.22.3960.3960.

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Abstract Abstract 3960 Poster Board III-896 Introduction Rare cases of histiocytic sarcoma (HS) have been reported in association with indolent small B-cell neoplasms, either concurring with or following a small B-cell lymphoma. The biologic relationship between these two morphologically and immunophenotypically distinct neoplasms in same patients remains unclear, though recent data suggest a possible “transdifferentiation” from follicular lymphoma (FL) to HS. Patients and Methods We investigate the clonal relationship in two cases of B-cell lymphoma with subsequent HS, using immunohistochemic

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Kwatra, Kanwardeep Singh, Preethi A. M. Paul, Nalini Calton, Joseph M. John, and James D. Cotelingam. "Systemic and primary cutaneous anaplastic large cell lymphoma: Clinical features, morphological spectrum, and immunohistochemical profile." South Asian Journal of Cancer 06, no. 03 (2017): 129–31. http://dx.doi.org/10.4103/2278-330x.214575.

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Abstract Background: T-cell lymphomas with anaplastic morphology typically comprise of anaplastic lymphoma kinase positive, anaplastic large cell lymphoma (ALK+ ALCL), ALK-negative ALCL (ALK- ALCL), and primary cutaneous ALCL (PC-ALCL). However, other entities such as diffuse large B-cell lymphoma, peripheral T-cell lymphoma, Hodgkin lymphoma, and undifferentiated carcinoma can also show similar anaplastic features. Aims: To study the clinical features and histological spectrum of ALCL and emphasize the role of immunohistochemistry (IHC) in their diagnosis and categorization. Setting and Desig

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Bertoni, Francesco, Andrea Rinaldi, Anna Sasso, et al. "Inhibition of the B Cell Associated Tyrosine Kinase SYK as a Potential Therapeutic Target in Aggressive Lymphomas." Blood 106, no. 11 (2005): 1469. http://dx.doi.org/10.1182/blood.v106.11.1469.1469.

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Abstract By using a combination of genomic and expression profiling (Affymetrix GeneChip Mapping 10k Xba131 and U133 set), we had previously analysed a series of 26 mantle cell lymphoma (MCL) samples to identify regions containing genes that might be relevant to MCL pathogenesis and that could represent new therapeutic targets (Rinaldi et al, Ann Oncol2005; vol. 16 suppl. 5, abstract 447). Of interest, one MCL cell line showed a genomic amplification of 9q22 with concomitant over-expression of SYK, mapped within the region. SYK is a tyrosine kinase involved in B cell receptor signaling, a path

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