Academic literature on the topic 'FISH, LYMPHOMA'

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Journal articles on the topic "FISH, LYMPHOMA"

1

Meloni-Ehrig, Aurelia, Christine A. Curtis, Sean P. Mahoney, et al. "Significance of Conventional Cytogenetics in Improving the Diagnosis and Prognosis of Lymphoid Neoplasms in Tissue Samples." Blood 126, no. 23 (2015): 5033. http://dx.doi.org/10.1182/blood.v126.23.5033.5033.

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Abstract Cytogenetic analysis is invaluable for the detection of chromosome abnormalities in tumor samples and is the "gold standard" technique (unique in providing a complete overview of the chromosome complement). Cytogenetic studies of lymph node specimens (LN) can be challenging due to progressively smaller biopsies being procured, low viability, and low proliferative rates. Typically, the initial laboratory evaluation of LN includes flow cytometry and/or immunohistochemistry. Due to overlapping immunophenotypic and morphologic features of some lymphomas, these studies can be insufficient
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2

O’Neill, John Patrick, Fiona Quinn, Anita Dowling, et al. "Composite t(14;18)-Negative Follicular Lymphoma and Nodular Lymphocyte-Predominant Hodgkin Lymphoma." Case Reports in Hematology 2018 (August 2, 2018): 1–4. http://dx.doi.org/10.1155/2018/4312594.

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A composite lymphoma is the rare simultaneous occurrence of two or more distinct lymphomas within a single tissue or organ. Herein, we describe a case of a 51-year-old man presenting with a history of lower limb rash, fatigue, and bulky abdominopelvic lymphadenopathy. An excisional left iliac lymph node biopsy was notable for the composite presence of two distinct lymphoid neoplasms, nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), and follicular lymphoma (FL). Multiplex PCR and FISH analyses failed to demonstrate a t(14;18)(q32;q21) translocation in either composite lymphoma component
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3

Streubel, Berthold, Andrea Lamprecht, Judith Dierlamm, et al. "T(14;18)(q32;q21) involving IGH andMALT1 is a frequent chromosomal aberration in MALT lymphoma." Blood 101, no. 6 (2003): 2335–39. http://dx.doi.org/10.1182/blood-2002-09-2963.

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T(11;18)(q21;q21) is the most common structural abnormality in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) leading to the fusion of the apoptosis inhibitor-2 (API2) gene and the MALT lymphoma-associated translocation (MALT1) gene. In 2 patients with MALT lymphoma of the liver and skin, respectively, t(14;18)(q32;q21) was observed by cytogenetic analysis. Subsequent fluorescence in situ hybridization (FISH) studies disclosed that the immunoglobulin heavy-chain locus (IGH) and the MALT1 gene were rearranged by this translocation. In order to scre
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4

Zhang, John, David Chin, Adam Anthony, et al. "CD5 and CD23 Positive Mantle Cell Lymphoma Detected by Flow Cytometry and Confirmed by FISH Study t(11;14)." Blood 104, no. 11 (2004): 4814. http://dx.doi.org/10.1182/blood.v104.11.4814.4814.

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Abstract The differential diagnoses of CD5 positive B-cell lymphoproliferative disorders mainly include chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and mantle cell lymphoma. Occasionally large cell and marginal zone lymphomas may also be CD5 positive. An accurate diagnosis effects patient management. The classical immunophenotype for chronic lymphocytic leukemia/small lymphocytic lymphoma is CD19/CD5/CD23 positive FMC-7 negative cells with dim CD20 and dim light chain expressions, while mantle cell lymphoma is CD19/CD5/FMC-7 positive with bright CD20 and bright light chai
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5

O'Connor, Sheila J. M., Kathryn Turner, Catherine H. Burton, and Andrew Jack. "Detection of BCL2 Gene Rearrangements in the Reed-Sternberg Cells of Composite Lymphomas or Newly Diagnosed Hodgkin Lymphoma in Patients with a Previous Diagnosis of Follicular Lymphoma." Blood 124, no. 21 (2014): 137. http://dx.doi.org/10.1182/blood.v124.21.137.137.

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Abstract Introduction: Composite lymphomas involving Hodgkin lymphoma (HL) and non-Hodgkin lymphomas (CLL, DLBCL, FL, MZL, MCL, T-NHL) are relatively rare but are increasingly frequently diagnosed. This may be a function of the change in diagnostic practice, the more varied and increased treatment of the presenting disease or simply reflect better monitoring post treatment with re-biopsy of lymph nodes. Composite lymphoma is defined as the synchronous and metachronous development of two or more lymphomas in the same patient. The mechanism of pathogenesis underlying its occurrence is not clearl
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6

Safley, Anne M., Patrick J. Buckley, Andrew J. Creager, et al. "The Value of Fluorescence In Situ Hybridization and Polymerase Chain Reaction in the Diagnosis of B-Cell Non-Hodgkin Lymphoma by Fine-Needle Aspiration." Archives of Pathology & Laboratory Medicine 128, no. 12 (2004): 1395–403. http://dx.doi.org/10.5858/2004-128-1395-tvofis.

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Abstract Context.—Molecular genetic analyses have been predicted to improve the diagnostic accuracy of fine-needle aspiration of B-cell non-Hodgkin lymphoma. Objective.—To determine the value of routine molecular genetic assays, polymerase chain reaction (PCR) and fluorescence in situ hybridization (FISH), in the diagnosis of B-cell non-Hodgkin lymphoma by fine-needle aspiration (FNA). Design.—A multiparametric method, including cytology, flow cytometry, PCR, and FISH, was prospectively evaluated in the diagnosis of B-cell non-Hodgkin lymphoma by FNA. Aspirates from 30 consecutive patients wit
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7

Mitter, Navnit S., Stephen Lanno, Jason Blackson, Michelle Donskoy, and Ralph Ehrenpreis. "Development of a Reflex FISH Assay Panel for Lymphoid Neoplasms Resulted Negative by Cytogenetics and Current FISH Panel and Positive by Hematopathology." Blood 114, no. 22 (2009): 4722. http://dx.doi.org/10.1182/blood.v114.22.4722.4722.

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Abstract Abstract 4722 Fluorescence in situ hybridization (FISH) panel for detecting lymphoid neoplasms in interphase nuclei currently used at most of the laboratories initially utilizes the IGH (14q32.3) locus specific probe and based on negative or positive results obtained, additional testing is done with either the BCL6 (3q27), MYC (8q24) and MALT1 (18q21) locus specific probes, or the MYC/IGH (8q24/14q32.3), CCND1/IGH (11q13/14q32.3) and IGH/BCL2 (14q32.3/18q22) locus specific probes, respectively. Although these probes detect a large number of lymphoma-related abnormalities, approximatel
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8

Verghese, Cherian, Weihong Li, Nanuli Gvazava, et al. "IGH/BCL2 Status Better Predicts Clinico-Pathological Behavior in Primary Splenic Follicular Lymphoma than Histological Grade and Other Molecular Markers." Clinical Pathology 15 (January 2022): 2632010X2211292. http://dx.doi.org/10.1177/2632010x221129242.

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Splenic lymphoma may be primary or secondary. Primary splenic lymphoma’s are rare and usually of follicular cell origin representing <1% of Non-Hodgkin’s Lymphoma’s. Most are secondary with 35% representing Marginal Cell sub-type with the rest being Diffuse Large B-Cell Lymphoma’s. Unlike the uniformly aggressive clinical course of Diffuse Large B-Cell Lymphoma’s, biological behavior of Primary Splenic CD10-Positive Small B-Cell Lymphoma/Follicular Lymphoma remains less well defined. We present here a solitary splenic mass confirmed as Primary Splenic CD10-Positive Small B-Cell Lymphoma/Fol
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9

Dierlamm, Judith, Mathijs Baens, Margarita Stefanova-Ouzounova, et al. "Detection of t(11;18)(q21;q21) by interphase fluorescence in situ hybridization using API2 and MLTspecific probes." Blood 96, no. 6 (2000): 2215–18. http://dx.doi.org/10.1182/blood.v96.6.2215.

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Abstract The translocation of chromosome 11, long arm, region 2, band 1, to chromosome 18, long arm, region 2, band 1 (t(11;18)(q21;q21)) represents a recurrent chromosomal abnormality in extranodal marginal zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue (MALT) type and leads to a fusion of the apoptosis inhibitor-2 (API2) gene on chromosome 11 and the MALT lymphoma-associated translocation (MLT) gene on chromosome 18. A 2-color fluorescence in situ hybridization (FISH) assay, which can be used for the detection of t(11;18) in interphase nuclei and metaphase chromosomes on f
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10

Dierlamm, Judith, Mathijs Baens, Margarita Stefanova-Ouzounova, et al. "Detection of t(11;18)(q21;q21) by interphase fluorescence in situ hybridization using API2 and MLTspecific probes." Blood 96, no. 6 (2000): 2215–18. http://dx.doi.org/10.1182/blood.v96.6.2215.h8002215_2215_2218.

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The translocation of chromosome 11, long arm, region 2, band 1, to chromosome 18, long arm, region 2, band 1 (t(11;18)(q21;q21)) represents a recurrent chromosomal abnormality in extranodal marginal zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue (MALT) type and leads to a fusion of the apoptosis inhibitor-2 (API2) gene on chromosome 11 and the MALT lymphoma-associated translocation (MLT) gene on chromosome 18. A 2-color fluorescence in situ hybridization (FISH) assay, which can be used for the detection of t(11;18) in interphase nuclei and metaphase chromosomes on fresh and
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