Dissertations / Theses on the topic 'Fields of Research – 270000 Biological Sciences – 270100 Biochemistry and Cell Biology'
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Cooney, Terrence Patrick. "Studies on the biosynthesis of indole-3-acetic acid in tomato shoots." Thesis, University of Auckland, 1989. http://hdl.handle.net/2292/2071.
Full textSnowden, Kimberley Cathryn. "The molecular response of wheat roots to aluminium stress." Thesis, University of Auckland, 1994. http://hdl.handle.net/2292/1967.
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Henry, Stephen Michael. "Further insight into the Lewis histo-blood-group system as revealed from study of Polynesian and Caucasian plasma and erythrocyte glycosphingolipids." Thesis, University of Auckland, 1993. http://hdl.handle.net/2292/1975.
Full textHieber, A. David (Andrew David) 1966. "Characterisation of glycoprotein II from bovine adrenal medulla." Thesis, University of Auckland, 1993. http://hdl.handle.net/2292/1988.
Full textHiyama, Jun. "Isolation and characterisation of N-glycans of ovine and human luteinizing hormones." Thesis, University of Auckland, 1991. http://hdl.handle.net/2292/1989.
Full textPodivinsky, Ellen. "Molecular studies on actinidin, a cysteine protease from kiwifruit." Thesis, University of Auckland, 1991. http://hdl.handle.net/2292/2001.
Full textSpiers, Andrew J. (Andrew Julian). "Molecular and genetic analysis of RepA from the P307 RepFIB replicon." Thesis, University of Auckland, 1992. http://hdl.handle.net/2292/2044.
Full textDaja, Mirella Maria. "Enzyme activities associated with gonadotropic hormones." Thesis, University of Auckland, 1993. http://hdl.handle.net/2292/2311.
Full textJanssen, Bart-Jan. "Agrobacterium-mediated gene transfer into kiwifruit." Thesis, University of Auckland, 1991. http://hdl.handle.net/2292/2313.
Full textMerriman-Smith, B. Rachelle. "Glucose Transporters in Diabetic Complications of the Lens." Thesis, University of Auckland, 2001. http://hdl.handle.net/2292/2338.
Full textSimpson, Robert Malcolm. "The biosynthesis and control of indoleacetic acid." Thesis, University of Auckland, 1993. http://hdl.handle.net/2292/2344.
Full textTaylor, Jacqueline Ann, and Jackie (name change) O'Flaherty. "Factors affecting the metabolic control of cytosolic and lysosomal glycogen levels in the liver." Thesis, University of Auckland, 1985. http://hdl.handle.net/2292/2380.
Full textPowell, Kevin F. H. (Kevin Frederick Herbert). "Gene sequencing and in vitro synthesis of the rotavirus non-structural glycoprotein." Thesis, University of Auckland, 1986. http://hdl.handle.net/2292/2385.
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Beuning, Lesley L. "Cytokinins and the division or expansion of plant cells." Thesis, University of Auckland, 1988. http://hdl.handle.net/2292/2406.
Full textKennedy, Martin A. "Transcriptional promoters in a replication region of F plasmid." Thesis, University of Auckland, 1986. http://hdl.handle.net/2292/2482.
Full textHole, Rebecca. "Mammalian ADP-dependent glucokinase : a thesis presented in partial fulfilment of the requirement for the degree of Master of Science in Biochemistry at Massey University, Palmerston North, New Zealand." Massey University, 2009. http://hdl.handle.net/10179/1154.
Full textMacAskill, Ursula Kate. "A structural investigation of squash aspartic peptidase inhibitor (SQAPI) using Nuclear Magnetic Resonance spectroscopy (NMR) : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University, Palmerston North, New Zealand." Massey University, 2007. http://hdl.handle.net/10179/985.
Full textGrievink, Hilbert. "Malignant hyperthermia: allele specific expression and mutation screening of the ryanodine receptor 1 : a dissertation presented to Massey University in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Biochemistry." Massey University, 2009. http://hdl.handle.net/10179/1051.
Full textMuir, Matthew Stewart. "Proteomics of the ovine cataract." Diss., Lincoln University, 2008. http://hdl.handle.net/10182/792.
Full textClark, Alice Rosemary. "The filamin A actin binding domain structure and function: implications for a gain-of-function mechanism for the otopalatodigital syndrome: a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biochemistry at Massey University, Palmerston North, New Zealand [Ph. D] EMBARGOED." Massey University, 2010. http://hdl.handle.net/10179/1185.
Full textThe filamin family act as scaffolding proteins associating with actin filmanents, acting through a highly conserved actin binding domain (ABD). The ABD of the filamins is homologous to that found in other F-actin binding proteins such as dystrophin. Mutations in the filamin A gene cause a wide range of disease symptoms in humans reflecting the diversity of the roles that filamin A has in cell structure and signalling pathways. The diseases fall into two separate phenotypic groups. Periventricular nodular heterotopia (PVNH) generally results from the complete loss of filamin A protein, and affects the central nervous system. The clinically separate otopalatodigital disorders (OPD) spectrum disorders are skeletal disorders and were hypothesised to be gain of function phenotype diseases. At the beginning of this work, there was very little structural data available for the human filamins, and none for the crucial highly conserved actin binding domain. This lack of structural data limited the interpretation of the biochemical and genetic data and constrained our understanding of the disease associated mutations that cluster in this domain. These studies aimed to provide insights into the structure and mechanism of actin binding domains, and thus provide a better understanding of the diseases caused when this domain is mutated. A secondary structural analysis and crystal structures of the wildtype and OPD2 associated mutant ABDs were obtained. The overall fold of the three proteins was equivalent as determined by circular dichroism spectroscopy and x-ray crystallography. The ABD from filamin A E254K showed 3.7 fold increased F-actin affinity, accompanied by a reduced thermostability (of 5.6 °C). Western blotting of OPD2, frontometaphyseal dysplasia (FMD) and PVNH patient fibroblast lysates showed similar levels of filamin A compared to the control cells. In addition the OPD and PVNH patient fibroblasts were able to adhere to fibronectin and migrate with an equivalent rate to control cells. Together these results have allowed correlations to be developed between structure, protein stability, actin affinity, cellular phenotype and the overall clinical phenotype. Showing that, at least in one example, OPD2 may be due to an increased actin affinity providing further evidence for a gain of function mechanism of OPD2.
Bulman, S. R. "Testing the effect of in planta RNA silencing on Plasmodiophora brassicae infection." Lincoln University, 2006. http://hdl.handle.net/10182/1856.
Full textMcDermott, Joshua D. "The ovine lens cytoskeleton." Lincoln University, 2007. http://hdl.handle.net/10182/700.
Full textLei, Jie. "The role of antioxidants in the hydrogen peroxide-induced opacification of sheep lens." Master's thesis, Lincoln University. Agriculture and Life Sciences Division, 2006. http://theses.lincoln.ac.nz/public/adt-NZLIU20070517.162145/.
Full textMathews, Antony James. "Studies on chemically modified cytochromes Cl2." 1985. http://hdl.handle.net/2292/1744.
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Stapleton, Patricia M. (Patricia Mary). "Molecular genetics of restriction fragment length polymorphisms linked to the Huntington disease locus." 1988. http://hdl.handle.net/2292/2601.
Full textRobertson, Andrew James. "The bovine spliceosomal U1 small nuclear ribonucleoprotein particle : a study of its autoantigenicity and biochemical properties : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Biochemistry at Massey University, Palmerston North, New Zealand." 2006. http://hdl.handle.net/10179/1504.
Full textWebby, Celia Jane. "Structural & functional characterization of 3-Deoxy-d-arabino-heptulosonate 7-phosphate synthase from Helicobacter pylori & Mycobacterium tuberculosis : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biochemistry at Massey University, Turitea, Palmerston North, New Zealand." 2006. http://hdl.handle.net/10179/1584.
Full textThe shikimate pathway, responsible for the biosynthesis of aromatic compounds, is found in microorganisms and plants but absent in higher organisms. This makes the enzymes of this pathway attractive as targets for the development of antibiotics and herbicides. Recent gene disruption studies have shown that the operation of the shikimate pathway is essential for the viability of M. tuberculosis, validating the choice of enzymes from this pathway as targets for the development of novel anti-TB drugs. 3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAH7PS) catalyzes the first committed step of the shikimate pathway. Two distinct classes of DAH7PS have been defined based on sequence similarity. The type I DAH7PSs are well characterized, however prior to this project there was limited mechanistic and no structural information about type II enzymes. Sequence identity between type I and type II enzymes is less than 10% raising the possibility that they represent distinct protein families, unrelated by evolution. We have functionally characterized the type II enzyme from Helicobacter pylori, and have shown that type I and type II enzymes catalyze a metal-dependent ordered sequential reaction following the same stereochemical course. We have solved the structure of the type II DAH7PS from M. tuberculosis using single-wavelength anomalous diffraction (SAD) methods and the structure reveals a tightly associated dimer of (β/α)8 TIM barrels. The monomer fold, the arrangement of key residues in the active site, and the binding modes of PEP and Mn2+, all match those of the type I enzymes. This similarity of protein fold and catalytic architecture makes it unequivocal that type I and type II enzymes are related by divergent evolution from a common ancestor. Interestingly, there are significant differences in the additional structural elements that extend from the core (β/α)8 barrel and in the quaternary structure. Further structural and functional analysis of M. tuberculosis DAH7PS revealed that the two major additions decorating the barrel are involved in the binding of the aromatic amino acids. Two distinct inhibitory binding sites for Trp and Phe have been identified providing an explanation for the synergistic inhibition displayed with Trp and Phe. The role of several active site residues of Mt-DAH7PS in enzyme catalysis has also been investigated.
Bennett, Matthew David. "The structure and function of esterases from lactic acid bacteria : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosphy in the Institute of Molecular BioSciences, Massey University, New Zealand." 2007. http://hdl.handle.net/10179/810.
Full textBenny, Athol Graeme. "An integrated process for the recovery of clinically significant trace proteins from human plasma." 1990. http://hdl.handle.net/2292/2157.
Full textGlyn-Jones, Sarah. "Investigation of diabetic cardiomyopathy and its treatment by copper chelation." 2008. http://hdl.handle.net/2292/2421.
Full textSchwalbe, Martin. "Intrinsic disorder and coiled coil formation in prostate apoptosis response factor-4 (Par-4) : submitted in fulfilment of the requirements of the degree of Doctor of Philosphy, Institute of Fundamental Sciences, Massey University, New Zealand." 2010. http://hdl.handle.net/10179/1688.
Full textSaikia, Sanjay. "Functional analysis of Penicillium paxilli genes required for biosynthesis of paxilline : this thesis is presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy (PhD) in Biochemistry at Massey University, Palmerston North, New Zealand." 2006. http://hdl.handle.net/10179/1489.
Full textChen, Chunhong. "Structure function studies on lectin nucleotide phosphohydrolases (LNPs)." 2008. http://hdl.handle.net/2292/3369.
Full textYeoman, Jeffrey Aaron. "Biochemical characterization of metal-dependent 3-deoxy-D-manno-octulosonate 8-phosphate synthases from Chlorobium tepidum & Acidithiobacillus ferrooxidans : a thesis presented in partial fulfillment of the requirements for the degree of Masterate of Science in Biochemistry at Massey University, Turitea, Palmerston North, New Zealand." 2007. http://hdl.handle.net/10179/706.
Full textPoulsen, Raewyn Carol. "Long chain polyunsaturated fatty acids and their possible interaction with phytoestrogens : impact on bone and bone cell function in vivo and in vitro : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Biochemistry at Massey University, Palmerston North, New Zealand." 2007. http://hdl.handle.net/10179/1595.
Full textSato, Keisaku. "A functional analysis of RYR1 mutations causing malignant hyperthermia : a thesis presented to Massey University in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biochemistry." 2009. http://hdl.handle.net/10179/1228.
Full textStarck, Carlene Sheree. "The human myostatin precursor protein : structure, function and amyloid formation : implications for the muscle wastage disease sporadic inclusion body myositis : a dissertation presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biochemistry at Massey University, Palmerston North, New Zealand." 2010. http://hdl.handle.net/10179/1408.
Full textKoehn, Henning. "Differentially regulated proteins in breast cancer chemotherapy : a thesis presented to Massey University in partial fulfilment of the requirement for the degree of Doctor of Philosophy in Biochemistry." 2005. http://hdl.handle.net/10179/1554.
Full textMagan, Natisha. "Protein interactions at the human topoisomerase II[alpha] promoter : a thesis presented to Massey University in partial fulfilment of the requirement for the degree Doctor of Philosophy in Biochemistry." 2009. http://hdl.handle.net/10179/1292.
Full textNikmatullah, Aluh. "Regulation of ethylene biosynthesis in vegetative tissues of white clover (Trifolium repens L.) during water deficit : a thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Plant Biology, Institute of Molecular Biosciences, Massey University, Palmerston North, New Zealand." 2009. http://hdl.handle.net/10179/1229.
Full textRutherford, William Ernest. "Epigenetic characterisation of the 06 methyl-guanine DNA-methyltransferase promoter in New Zealand melanoma cell lines : a thesis presented to Massey University in partial fulfillment of the requirements for the degree of Master of Science in Biochemistry at Massey University, Palmerston North, New Zealand." 2010. http://hdl.handle.net/10179/1414.
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