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Dissertations / Theses on the topic 'Fibroblast growth factors'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2024

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1

Patel, Ambreen. "Fibroblast growth factors and retinal cell genesis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0025/MQ48033.pdf.

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2

Detvisitsakun, Chanitchote. "Functional characterization of a Baculovirus fibroblast growth factor." Diss., Manhattan, Kan. : Kansas State University, 2006. http://hdl.handle.net/2097/239.

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3

Harmer, N. J. "Structural studies of fibroblast growth factors and their receptors." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603723.

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Recent crystal structures have suggested two models for the complex between FGFs, FGF receptors (FGFRs) and the proteoglycan heparin that mediates signalling, and have provided insight into how FGFs show differing affinities for the range of FGFRs. I have examined complexes of FGF, FGFR and heparin by size-exclusion chromatography, analytical ultracentrifugation and mass spectrometry. This analysis suggests that both of the crystal structures faithfully represent the state of the molecules in solution. From this, I conclude that the origin of the difference in the two models lies in the prepar

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4

Ding, Su Sin. "Fibroblast growth factors in gastrointestinal development, homeostasis and injury." Thesis, Imperial College London, 2009. http://hdl.handle.net/10044/1/5497.

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Fibroblast growth factors (FGFs) and their receptors (FGFRs) are essential for controlling cell growth and proliferation, angiogenesis, wound healing and tumourigenesis. In mammals, there are twenty-three FGFs and five FGFRs, with each FGFR having different ligand binding specificities. FGFs are thought to act in a paracrine manner, in which they are secreted by one cell and activate FGFRs on another cell type, and such interaction helps to establish the fundamental crosstalk between epithelium and mesenchyme during development, homeostasis and tumourigenesis. This thesis aims to investigate t

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5

Moenner, Michel. "Étude du mécanisme d'action des facteurs de croissance "Fibroblast Growth Factors" (FGF)." Paris 12, 1988. http://www.theses.fr/1988PA120010.

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Pour les deux types cellulaires etudies, il apparait que le signal mitogene induit par la formation du complexe fgf-recepteurs est independant de l'activation du cycle des polyphosphoinositides et de l'activation de la proteine kinase c

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6

Moenner, Michel. "Etude du mécanisme d'action des facteurs de croissance "fibroblast growth factors", FGF." Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb376165817.

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7

Scarpa, Richard C. "Neurotensin potentiates the proliferative effects of growth factors in human embryonic lung fibroblasts /." Thesis, Connect to Dissertations & Theses @ Tufts University, 2004.

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Thesis (Ph.D.)--Tufts University, 2004.<br>Adviser: David E. Cochrane. Submitted to the Dept. of Biology. Includes bibliographical references (leaves 137-165). Access restricted to members of the Tufts University community. Also available via the World Wide Web;

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8

Abud, Helen E. "Examination of methods for the study of FGFs during mouse development." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260765.

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9

Vidyasagar, Rishma. "Characterisation of a suitable surface for the study of FGF : oligosaccharide interactions." Thesis, University of Liverpool, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288274.

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10

Yeoh, Joyce Siew Gaik. "Regulatory role of fibroblast growth factors on hematopoietic stem cells." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2007. http://irs.ub.rug.nl/ppn/299000842.

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11

Pulkkinen, Mari-Anne. "Role of epidermal and fibroblast growth factors in pancreatic development." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/laa/haart/vk/pulkkinen/.

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12

Braithwaite, Vickie. "Predictors of rickets in the Gambia : fibroblast growth factor-23." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607859.

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13

Rowntree, Sharon R., and University of Lethbridge Faculty of Arts and Science. "Basic fibroblast growth factor in the injured brain." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 1995, 1995. http://hdl.handle.net/10133/38.

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Basic fibroblast growth factor (bFGF) has been implicated in the brain's trophic response to injury. This thesis examined the effects of endogenous bFGF on brain plasticity and recovery of behavioral function following cortical injury in adult rats. The first experiment investigated the post-lesion time course of the astrocytic expression of bFGF. Subsequent experiments examined the effects of injury-induced bFGF on neuroonal morphology, cortical morphology, and post-lesion behavioral deficits. Following motor cortex injury, endogenous bFGF prevented neuritic degeneration in layer V pyramidal

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14

Chen, Pei-Yu. "Fibroblast Growth Factor Receptor-1 (FGFR1) in Vascular Smooth Muscle Cell Phenotypic Switch." Fogler Library, University of Maine, 2009. http://www.library.umaine.edu/theses/pdf/ChenPY2009.pdf.

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15

Waite, Wendy Lou, and University of Lethbridge Faculty of Arts and Science. "Basic fibroblast growth factor enhances recovery in rats." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2003, 2003. http://hdl.handle.net/10133/208.

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This thesis examined the role of exogenous basic fibroblast growth factor (FGF-2) in stimulating recovery after early cortical injury. Rats with medial prefrontal cortex (MFC), posterior parietal cortex (PPC), or sham lesions at postnatal day 3 (P3) received one of three variations of FGF-2 treatment: postnatal FGF-2 that was either pre-mixed or prepared daily, or prenatal FGF-2, and tested in adulthood. Behavioral tests used were: 1) the Morris Water task and, 2) the Whishaw Tray Reaching task. The level of functional recovery attained was dependent on FGF-2 preparation and the developmental

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16

Maker, Garth Lucas. "Regulation of surfactant production by fetal type II pneumocytes and characterization of fibroblast-pneumocyte factor /." Access via Murdoch University Digital Theses Project, 2007. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20080430.141113.

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17

Yu, Bei. "Basic fibroblast growth factor as a therapeutic target for chemosensitization in colorectal cancer." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1142882177.

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18

Smith, Simone Marsha-Lee. "The proteoglycan perlecan regulates long bone growth through interactions with developmental proteins in the growth plate." [Tampa, Fla.] : University of South Florida, 2007. http://purl.fcla.edu/usf/dc/et/SFE0002155.

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19

Tanenbaum, Michael David. "Control of angiogenic responses through an evolutionary conserved sequence of fibroblast growth factor." Thesis, Georgia Institute of Technology, 2003. http://hdl.handle.net/1853/20209.

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20

Walsh, Colin T. "Molecular pharmacodynamics of chemotherapy fibroblast growth factor (FGF) inhibitors as chemosensitizers /." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1126212295.

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21

Gallego-Llamas, Jabier. "Retinoic acid and Fibroblast Growth Factors during segmentation and somite formation." Université Louis Pasteur (Strasbourg) (1971-2008), 2007. http://www.theses.fr/2007STR13249.

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Au cours de la somitogénèse, l’action combinée d’un oscillateur moléculaire et la progression d’un front de détermination conduit à la formation périodique et synchronisée des somites. La régulation de la somitogénèse est sous le contrôle de plusieurs voies de signalisation dont les voies Notch, Wnt et Fgf. Récemment nous avons montré l’importance de l’acide rétinoïque (AR) dans cette cascade pour le positionnement correct des frontières somitiques de la synchronisation gauche/droite des oscillations moléculaires. L’asymétrie induite par la déficience en AR semble entre autre passer par la rég

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22

陸梅 and Mei Lu. "Allogeneic bone grafts mixed with basic fibroblast growth factor: a cellular and molecular study." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B29866340.

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23

Seet, Li Fong. "Characterization of the biological properties of FGF-9." Thesis, University of Oxford, 1996. http://ora.ox.ac.uk/objects/uuid:a46cee92-c179-4d22-b27b-0e67c3c85a37.

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The fibroblast growth factor family of polypeptides currently consists of nine structurally-related members. Cloning of the mouse homologue of the latest reported member of the family, FGF-9, is described in this study. Mouse Fgf9 exhibits a high level of sequence conservation with the human, rat and Xenopus counterparts. Of note is the lack of a hydrophobic signal peptide at the N-terminus of the coding sequence. The protein, however, appeared to be secreted by producer cells since a significant quantity of the protein could be purified from the culture supernatant of transfected cells. Membe

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24

Zamora, Brian G. "Functions of Rx in early vertebrate ocular development." Morgantown, W. Va. : [West Virginia University Libraries], 2009. http://hdl.handle.net/10450/10830.

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Thesis (Ph. D.)--West Virginia University, 2009.<br>Title from document title page. Document formatted into pages; contains x, 148 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 136-148).

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25

Nash, Gordon W. "Characterization of fibroblast growth factor receptor type I isoforms in Xenopus laevis embryonic development /." Internet access available to MUN users only, 2003. http://collections.mun.ca/u?/theses,167327.

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26

Schuschereba, Steven Theodore. "An investigation of factors modulating wound healing after laser damage to the retina." Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251783.

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27

Pierce, Paul Randall 1951. "Control of fibroblast contamination in primary rat skeletal muscle cell cultures: Effects of an epidermal growth factor linked cytotoxin." Thesis, The University of Arizona, 1988. http://hdl.handle.net/10150/276812.

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The in vitro study of muscle cell growth is hampered by the presence of non-muscle cells, particularly fibroblasts. The heterobifunctional cross-linking agent, N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP) has been used to create a novel "toxic growth factor" to address the problem. Epidermal growth factor (EGF), which stimulates fibroblast but not satellite cell proliferation, was conjugated via SPDP to a potent ribosome inhibitor, pokeweed antiviral protein (PAP). By preferentially binding to fibroblasts, it was hoped that EGF-PAP could cytotoxically eliminate fibroblasts from primary

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28

Ryan, Paula. "Characterization of the FGF receptor signaling complex in Xenopus laevis during early embryonic development /." St. John's, NF ; [s.n.], 1999.

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29

Butt, Richard Philip. "Effect of mechanical forces and polypeptide growth factors on cardiovascular fibroblast function." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363055.

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30

Baradji, A. "Interactions of fibroblast growth factors with glycosaminoglycan brushes and the pericellular matrix." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3019050/.

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31

Martin, Christopher School of Biomedical Engineering UNSW. "Investigation of exogenous growth factors; platelet derived growth factor, insulin-like growth factor binding protein and fibroblast growth factor, and their influence on in vivo bone repair." Awarded by:University of New South Wales. School of Biomedical Engineering, 2006. http://handle.unsw.edu.au/1959.4/30405.

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This research investigated if exogenous growth factors (GFs), in particular platelet derived growth factor (PDGF), has an in vivo effect on the healing response of normal healthy bone. The research was orientated to study whether a clinical beneficial effect could be demonstrated. To achieve this two animal models were utilised, namely, a rabbit tibial osteotomy model and an ovine tibial defect and porous implant ingrowth model. The rabbit model comprised of a unilateral V-shaped tibial osteotomy, stabilised with an absorbable intramedullary pin and figure-of-eight tension band suture, with a

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32

Drugan, Caroline S. "The role of fibroblast growth factors and their receptors in human oral carcinogenesis." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389231.

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33

McCabe, Kathryn Leigh. "The transition from progenitor cell to neuron : fibroblast growth factors and their role in retinal ganglion cell neurogenesis /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/10640.

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34

Bhatnagar, Sushant. "Fibroblast growth factor-19 a novel factor that inhibits hepatic fatty acid synthesis /." Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=6060.

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Thesis (Ph. D.)--West Virginia University, 2008.<br>Title from document title page. Document formatted into pages; contains ix, 86 p. : ill. (some col.). Includes abstract. Includes bibliographical references.

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35

Kreuger, Johan. "Decoding Heparan Sulfate." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5161-6/.

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36

Magnusson, Peetra. "Fibroblast Growth Factor Receptor-1 Function in Vasculo- and Angiogenesis." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5824.

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37

Song, Jihwan. "Cloning, expression and biological activity of fibroblast growth factors in early Xenopus development." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307020.

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38

Mehta, Piyush Bachoolal. "The roles of fibroblast growth factors and their receptors in human prostate cancer." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311115.

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39

Dorkin, Trevor John. "The role of fibroblast growth factors in the pathogenesis of human prostate cancer." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366585.

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40

Heer, Rakesh. "Characterisation of fibroblast growth factors in differentiation and carcinogenesis of the human prostate." Thesis, University of Newcastle Upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423723.

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41

Bresnick, Janine Nicola. "The fibroblast growth factors and their receptors in mammary gland development and malignancy." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307597.

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42

Wang, Jie. "Broad-Spectrum Protection Against Chemotherapy-Induced Alopecia by Acidic and Basic Fibroblast Growth Factors." The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1111433922.

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43

Knights, Victoria E. E. "Tumour cell responses to novel fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608393.

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44

Boulle, Nathalie. "Analyse du système des insulin-like growth factors (IGF) et du fibroblast growth factor-2 (FGF-2) dans la tumorigenèse corticosurrenalienne." Paris 11, 2000. http://www.theses.fr/2000PA11T006.

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Dans les tumeurs corticosurrénaliennes, des anomalies de la région 11p15 et une surexpression du gène d'IGF-11 sont contemporaines de l'acquisition du phénotype malin. Nous montrons que la surexpression du gène IGF-11 dans les tumeurs corticosurrénaliennes malignes s'accompagne d'une traduction efficace de la protéine, majoritairement sous forme de précurseurs d'IGF-11. Ces mêmes tumeurs surexpriment de manière spécifique IGFBP-2, protéine de liaison des IGF fréquemment associée à la prolifération tumorale. La caractérisation de la lignée H295R, dérivée d'un carcinome surrénalien, montre que c

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45

Li, Yu. "Cloning and characterization of a cDNA encoding er1 , a novel developmentally regulated FGF response gene." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0030/MQ47427.pdf.

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46

Fletcher, Michael. "Network analysis of fibroblast growth factor receptor 2-regulated gene expression in breast cancer." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608087.

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47

Pazmany, Csaba C. "In Vitro analysis of FGF-23 induced gene expression." Link to electronic thesis, 2003. http://www.wpi.edu/Pubs/ETD/Available/etd-0114103-160205.

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Thesis (M.S.)--Worcester Polytechnic Institute.<br>Keywords: factor; FGF-23; phosphatonin; microarray; expression; phosphate; time; gene; RT-PCR; growth; fibroblast. Includes bibliographical references (p. 127-136).

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48

Quennell, Janette Henrietta, and n/a. "Molecular and cellular biology of FGF2 in human ovarian follicles." University of Otago. Department of Anatomy & Structural Biology, 2006. http://adt.otago.ac.nz./public/adt-NZDU20061025.142115.

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Ovaries maintain and produce functional female gametes, oocytes, for fertilisation. Oocytes develop inside cellular assemblies, the ovarian follicles, before birth and can reside there for up to 50 years in the human. Despite recent inroads, the precise mechanisms of initial follicle recruitment and growth remain unclear. Although the pituitary gonadotrophins play a role in this developmental process, locally produced factors have been implicated strongly in initiation of follicle growth. It is known that fibroblast growth factor 2 (FGF2) is a powerful mitogen for follicular granulosa cells in

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49

Ge, Xuan, and 戈萱. "Fibroblast growth factor 21 as a key modulator of glucose uptake and lipolysis in adipocytes: molecular mechanismsand physiological implications." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hub.hku.hk/bib/B50434378.

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Fibroblast Growth Factor (FGF) 21 is a liver-derived endocrine factor with multiple metabolic effects on glucose and lipid homeostasis in animals. The adipose tissue has been proposed as a major target of FGF21, where it enhances glucose uptake and modulates lipolysis as well as thermogenesis. However, the molecular mechanisms underlying the pleiotropic effects of FGF21 in adipocytes and the physiological roles of FGF21 in regulating energy homeostasis remain poorly characterized. Therefore, the present study aimed to investigate: 1) the signal transduction pathway whereby FGF21 enhances g

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50

Christensen, Randolph N. "Fibroblast growth factors and the Apical Epithelial Cap in Axolotl (Ambystoma mexicanum) limb regeneration /." The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486399160104861.

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