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Dissertations / Theses on the topic 'Fibroblast growth factor 2 (FGF2)'

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Published: 14 March 2023

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1

Sullivan, Christopher James. "The role of fibroblast growth factor-2 (FGF2) in vascular remodeling and adaptation." Diss., The University of Arizona, 2002. http://hdl.handle.net/10150/284317.

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The goal of this dissertation was to test the hypothesis that fibroblast growth factor-2 (FGF2) is required during diseased-related vascular growth and remodeling in the adult organism. Given previous research, it is generally assumed that FGF2 is an important regulator of vessel growth during various pathophysiological processes (e.g. tissue ischemia, vessel injury, and flow-dependent remodeling). However, such studies only indirectly implicate FGF2 in vascular adaptation and remodeling. In contrast, experiments using mice with a targeted disruption of the Fgf2 gene have allowed direct determ

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2

Olson, Nels Eric. "FGF2 is weakly mitogenic for intimal smooth muscle cells : role of FGF receptor expression, cytoplasmic signaling and cell cycle regulation /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/6335.

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3

Kole, Denis. "Role of Fibroblast Growth Factor 2 in Maintenance of Multipotency in Human Dermal Fibroblasts Treated with Xenopus Laevis Egg Extract Fractions." Digital WPI, 2014. https://digitalcommons.wpi.edu/etd-dissertations/207.

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Current usage of human embryonic stem cells (hES) and induced pluripotent stem cells (iPS) in clinical therapies and personalized medicine are limited as a result of ethical, technical and medical problems that arise from isolation and generation of these cells. Isolation of hES cells faces ethical problems associated with their derivation from human pre-implantation embryos. The most controversial aspect of hES cell isolation targets the generation of autologous hES cell lines which requires the transfer of a somatic-cell nucleus from the patient to an enucleated oocyte. While already establi

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4

Kinkl, Norbert. "Mechanisms of action of fibroblast growth factor 2 (FGF2) in rat retinal cells : photoreceptor survival and intracellular signaling." Université Louis Pasteur (Strasbourg) (1971-2008), 2001. http://www.theses.fr/2001STR13166.

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La dégénérescence des photorécepteurs est à l'origine de nombreuses pathologies rétiniennes aboutissant à une malvoyance voire à la cécité. Les facteurs neurotrophiques représentent une approche thérapeutique potentielle. Au cours de cette thèse nous nous sommes intéressés aux mécanismes d'actions in vitro d'un facteur neurotrophique exprimé dans la rétine, le FGF2. Afin d'étudier les effets directs du FGF2 sur la survie des photorécepteurs, nous avons mis au point un nouveau modèle de culture pure en photorécepteurs à partir de rétine jeune de rat. La pureté en photorécepteurs des cultures es

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5

Hedlund, Eva-Maria. "Molecular mechanisms of angiogenic synergism between Fibroblast Growth Factor-2 and Platelet Derived Growth Factor-BB." Thesis, Södertörn University College, School of Life Sciences, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-932.

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6

RIZZO, ILARIA MARIA. "Biological role of sphingosine 1-phosphate in neuroblasts derived from otic vesicle." Doctoral thesis, Università di Siena, 2016. http://hdl.handle.net/11365/1009811.

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Hearing loss is a health and social problem, particularly common among older people. Deafness is associated with an irreversible loss of sensory hair cells and spiral ganglion neurons, which don’t have regenerative potential. To date, cochlear implants are the only possible therapy, even if not always effective. Therefore, there is an enormous research interest aimed at identifying factors that could prevent hearing loss. Sphingosine 1-phosphate (S1P) is a bioactive lipid involved in the regulation of many physiological and pathological processes. Most of S1P functions are mediated throu

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7

Manning, Janet R. "Fibroblast growth factor 2-mediated cardioprotection: the kinase mediators and downstream targets of FGF2-induced protection from ischemia and reperfusion injury." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1331296684.

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8

Aguiar, Rodrigo Barbosa de. "Aplicação diagnóstica e terapêutica de um novo anticorpo anti-FGF2 em processos de angiogênese em melanoma experimental." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-29102014-162446/.

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Evidências sugerem que o fator de crescimento de fibroblasto 2 (FGF2), produzido por melanomas, possui importante papel no crescimento tumoral, angiogênese e metástase. Assim, o uso de anticorpo monoclonal (mAb) que reconhece e bloqueia a atividade de FGF2 é uma abordagem a ser considerada em oncologia. O propósito desse estudo foi avaliar a aplicação diagnóstica e terapêutica de um novo anticorpo anti-FGF2, 3F12E7 IgG1, em melanoma experimental B16-F10. Para isso, camundongos C57Bl/6 foram implantados subcutaneamente (ou intravenosamente, para ensaios de metástase) com células de melanoma mur

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9

Adeyemo, Adeola T. "The Roles of the High and Low Molecular Weight Isoforms of Fibroblast Growth Factor 2 in Ischemia-Induced Revascularization." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1460444581.

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10

Ehrenfels, Yvonne. "Mutationen in den "fibroblast growth factor" (FGF)-Rezeptorgenen FGFR 1, 2 und 3 bei primären Craniosynostosen." [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=960357629.

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11

Kilkenny, Dawn M. "Fibroblast growth factor (FGF) receptor-1 and FGF-2 nuclear localization in proliferating growth plate chondrocytes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0021/NQ58142.pdf.

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12

Magnusson, Peetra. "Fibroblast Growth Factor Receptor-1 Function in Vasculo- and Angiogenesis." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5824.

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13

Wagner, Andreas. "Identifizierung von Genen, die durch fibroblast growth factor receptor 2 (FGFR2) reguliert werden." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=961705361.

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14

Maucher, Tobias [Verfasser]. "Regulation des glialen Glutamattransports durch den Wachstumsfaktor ''Fibroblast growth factor 2'' (FGF-2) / Tobias Maucher." Ulm : Universität Ulm. Medizinische Fakultät, 2004. http://d-nb.info/1015438520/34.

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15

SAKANAKA, MASAHIRO, SHIGERU KOBAYASHI, MINORU UEDA, et al. "THE LOCALIZATION OF BASIC FIBROBLAST GROWTH FACTOR (FGF-2) IN RAT SUBMANDIBULAR GLANDS." Nagoya University School of Medicine, 1994. http://hdl.handle.net/2237/16076.

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16

Boulle, Nathalie. "Analyse du système des insulin-like growth factors (IGF) et du fibroblast growth factor-2 (FGF-2) dans la tumorigenèse corticosurrenalienne." Paris 11, 2000. http://www.theses.fr/2000PA11T006.

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Dans les tumeurs corticosurrénaliennes, des anomalies de la région 11p15 et une surexpression du gène d'IGF-11 sont contemporaines de l'acquisition du phénotype malin. Nous montrons que la surexpression du gène IGF-11 dans les tumeurs corticosurrénaliennes malignes s'accompagne d'une traduction efficace de la protéine, majoritairement sous forme de précurseurs d'IGF-11. Ces mêmes tumeurs surexpriment de manière spécifique IGFBP-2, protéine de liaison des IGF fréquemment associée à la prolifération tumorale. La caractérisation de la lignée H295R, dérivée d'un carcinome surrénalien, montre que c

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17

Kirtland, David Rand. "Preparation of Heparin Surface for Quantification of Fibroblast Growth Factor-2 (FGF-2) Binding Using Surface Plasmon Resonance (SPR)." Thesis, Virginia Tech, 2005. http://hdl.handle.net/10919/33265.

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A mixed self assembling monolayer (mSAM) chip with attached heparin was developed to analyze heparin-protein interactions using a Reichert Inc, SR7000, surface plasmon resonance (SPR) instrument. The heparin was attached via streptavidin-biotin linkage where the streptavidin was covalently coupled to the mSAM and biotinylated heparin bound to it. These chips were then used to quantify the interactions of fibroblast growth factor-2 (FGF-2) with the surface bound heparin. Kinetic rate constants of association and disassociation were calculated. The association data of FGF-2 with heparin was

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18

Liao, Siyun. "The Role of Fibroblast Growth Factor-2 Isoforms in Ischemia-reperfusion Injury and Cardioprotection." University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1203690695.

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19

Filani, Oluwadamilola. "Expression and Purification of Unlabelled and Isotopically Labelled Human Fibroblast Growth Factor-1 and its Receptor Relevance in Cancer Research." TopSCHOLAR®, 2015. http://digitalcommons.wku.edu/theses/1549.

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Studies show that fibroblast growth factors (FGFs) control variety of cellular activities such as mitosis, cell differentiation, survival and angiogenesis. The FGF family consists of 23 different heparin-binding proteins. One of the most intensively studied members is human FGF-1 (hFGF-1) because of its critical role in the formation of blood vessels and cell proliferation in some types of cancer. The biological activities of FGFs are primarily mediated via interactions with fibroblast growth factor receptors (FGFR) and are a potent target in cancer. In this study, we report an efficient affin

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20

Gilbert, Emmanuelle. "L'épissage alternatif comme mécanisme de contrôle de l'expression du gène codant pour le récepteur-2 aux facteurs de croissance des fibroblastes." Nantes, 1994. http://www.theses.fr/1994NANT2096.

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Le gène FGFR2 code pour une famille de récepteurs des facteurs de croissance des fibroblastes (FGFS) dérivant du même pré-messager par le jeu d'épissages alternatifs. Quatre récepteurs à haute affinité pour ces facteurs ont été identifiés, de FGFR1 à FGFR4. Ces récepteurs sont tous bâtis sur le même modèle. Leur domaine extra-cellulaire est composé de trois boucles immunoglobuline-like et leur domaine intra-cellulaire possède une activité tyrosine kinase. La première partie de ce mémoire concerne la caractérisation des divers transcrits issus du gène FGFR2. Quatre extrémités carboxy-terminales

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21

Machado, Aline Zamboni. "Pesquisa de mutações nos genes FGF9 e FGFR2 em pacientes portadores de distúrbios do desenvolvimento sexual 46,XY por anormalidades no desenvolvimento gonadal." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-18092012-143903/.

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Introdução: Várias evidências em estudos de animais knockout sugerem a efetiva participação dos genes Fgf9-Fgfr2 no processo de determinação testicular. Animais XY knockout para os genes Fgf9 e Fgfr2 apresentam reversão sexual como consequência da alteração na cascata de eventos masculinizantes nas gônadas fetais. Até o momento, mutações inativadoras dos genes FGF9-FGFR2 não foram descritas em pacientes 46, XY portadores de disgenesia gonadal. Objetivos: Pesquisar a presença de mutações inativadoras nos genes FGF9 e FGFR2 em pacientes portadores de DDS 46,XY por anormalidades do desenvolviment

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22

Santiago, Jon-Jon. "Studies on high molecular weight fibroblast growth factor-2 isoforms produced by rat and human cardiac myofibroblasts." Oxford Journals, 2011. http://hdl.handle.net/1993/23867.

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Fibroblast growth factor-2 (FGF-2) is expressed as high molecular weight (> 20 kDa, Hi-FGF-2), or low molecular weight, (18 kDa, Lo-FGF-2) isoforms with distinct functions in the heart and other tissues. Studies to-date have focused on Lo-FGF-2, while the biology of Hi-FGF-2 is less well understood. This work investigated potential autocrine and paracrine effects of rat and human Hi-FGF-2 on cardiac myocytes and non-myocytes (myofibroblasts). Using rat ventricular myofibroblast cultures stimulated with angiotensin II (Ang II), in the absence or presence of YVAD, a peptide inhibitor of caspa

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23

Burger, Patricia E. "The effects of fibroblast growth factor-2 (FGF-2) on haematopoietic cells and the identification of those cells expressing FGF receptors." Doctoral thesis, University of Cape Town, 2002. http://hdl.handle.net/11427/3110.

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24

Tassone, Evelyne. "Extracellular matrix-degrading enzymes and control of fibroblast growth factor-2 (FGF-2) signaling in pediatric glioma cell lines." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422194.

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The main purpose of my research project was to investigate the role of two extracellular matrix-degrading enzymes, heparanase (HPSE) and membrane-type 1 matrix metalloproteinase (MT1-MMP), in pediatric gliomas. I spent the first two years of my PhD program in Dott. Maurizio Onisto’s laboratory (University of Padua). Then I continued my work at New York University School of Medicine, under the supervision of Prof. Paolo Mignatti, whose experimental work focuses on the molecular mechanisms of proteolysis-independent signaling by MT1-MMP and its physiological inhibitor, tissue inhibitor of metall

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25

Robbez-Masson, Luisa. "Investigating the functional significance of an FGFR2 intronic SNP in breast cancer." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8539.

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Single nucleotide polymorphisms present in the second intron of the fibroblast growth factor receptor 2 (FGFR2) gene have been linked with increased risk of breast cancer in several genome wide association studies. The potential effect of those SNPs appeared to be mediated through the differential binding of cis-regulatory elements, such as transcription factors, since all the SNPs in linkage disequilibrium were located in a regulatory DNA region. Preliminary studies have shown that a Runx2 binding site is functional only in the minor, disease associated allele of rs2981578, resulting in incre

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26

Brooks, Nicole E. "Fibroblast Growth Factor 21 Expression in Mice with Altered Growth Hormone Action: Links to Obesity, Type 2 Diabetes Mellitus, and Increased Longevity." Ohio University Honors Tutorial College / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1461161246.

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Dehkhoda, Farhad. "Identification and validation of FGFR2 mutations providing resistance to pan-FGFR inhibitor BGJ398." Thesis, Queensland University of Technology, 2014. https://eprints.qut.edu.au/114506/1/Farhad%20Dehkhoda%20Thesis.pdf.

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Endometrial cancer (EC) is the most commonly diagnosed gynaecological cancer, and is responsible for ~370 deaths per year in Australia and 8600 deaths annually in the USA. Fibroblast growth factor receptor 2 (FGFR2) mutations have been identified in ~ 12% of endometrial cancer patients and research confirms it is a valid therapeutic target. Tyrosine kinase inhibitors (TKIs) have been used in the last few years to treat patients with mutant receptor tyrosine kinases (RTKs). Despite patients showing an initial response to these TKIs, acquired resistance associated with cancer relapse often occur

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28

Elahouel, Rania. "Le Fibroblast Growth Factor 2 ( FGF-2 ) et la neuropiline-1 (NRP-1) : nouveaux partenaires moléculaires de Heparin Affin Regulatory Peptide ( HARP)." Thesis, Paris Est, 2012. http://www.theses.fr/2012PEST0066.

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HARP (Heparin Affin regulatory peptide) est un facteur de croissance qui constitue avec la midkine une sous-famille des Heparin Binding Growth Factors (HBGFs). HARP est impliqué dans de nombreux processus physiologiques comme la neurogenèse et la vasculogenèse mais aussi dans des processus physiopathologiques comme l’angiogenèse et la progression tumorale. HARP interagit avec différents récepteurs (N-syndécan, RPTPβ/ζ, et ALK). Plus récemment, il a été montré au laboratoire que la nucléoline, protéine navette entre le noyau, le cytoplasme, et la surface cellulaire est un nouveau récepteur à HA

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Krajewski, Anna Christina. "Die Regulation der Synthese und Freisetzung von FGF-2 aus humanen dermalen Mastzellen." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2006. http://dx.doi.org/10.18452/15404.

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Die Synthese und -Freisetzung von FGF-2 aus humanen dermalen Mastzellen Fibroblast growth factor-2 (FGF-2) ist ein Mitglied einer großen Familie von Wachstumsfaktoren. FGF-2 fördert das Wachstum und die Entwicklung von Blutgefäßen (Angiogenese) und nimmt somit Einfluss auf Wundheilungsprozesse, Gewebeentwicklung, als auch verschiedene pathologische Vorgänge im Organismus. Mastzellen wurden lange Zeit allein als Effektorzellen der Typ I Allergiereaktion betrachtet. Mittlerweile betrachten man sie auch als wichtige Zellen für die Gewebe Homöostase und Wundheilung. In der vorliegenden Arbeit w

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30

Kefalakes, Ekaterini Sofia [Verfasser]. "Role and putative therapeutic implications of fibroblast growth factor-2 (FGF-2)-dependent interplay of neurotrophic factors and signaling cascades in amyotrophic lateral sclerosis / Ekaterini Sofia Kefalakes." Hannover : Stiftung Tierärztliche Hochschule Hannover, 2018. http://d-nb.info/1178008851/34.

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31

Wang, Jie. "Fibroblast growth factor-2 protects neonatal rat cardiac myocytes from doxorubicin-induced damage via protein kinase C- dependent effects on efflux drug transporters." Cardiovascular Research, 2013. http://hdl.handle.net/1993/18318.

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Introduction: Therapeutic agents like doxorubicin, an anthracycline antibiotic drug, are widely used in cancer chemotherapy. The use of doxorubicin is limited however by an increased risk of cardiac damage as a side effect, and an increased cancer cell drug resistance mediated by efflux drug transporters. Strategies are needed to protect the heart and still allow the benefits of drug treatment. “Basic” fibroblast growth factor-2 (FGF-2) is a multi-functional protein. It is angiogenic and cardioprotective against ischemia-reperfusion injury. FGF-2 can also regulate cancer cell drug resistance

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Baron, Olga [Verfasser]. "Role of basic fibroblast growth factor (FGF-2) during development of mesencephalic dopaminergic neurons of substantia nigra in mice / Olga Baron." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2011. http://d-nb.info/1018928502/34.

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Kamali, Salar [Verfasser]. "Evaluation of the Fibroblast Growth Factor Receptor 2 (FGFR2) in Experimental Autoimmune Encephalomyelitis (EAE) and its Possible Role in Multiple Sclerosis (MS) / Salar Kamali." Gießen : Universitätsbibliothek, 2016. http://d-nb.info/1096137763/34.

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34

Ferraro, Bernadette. "Intradermal Delivery of Plasmids Encoding Angiogenic Growth Factors by Electroporation Promotes Wound Healing and Neovascularization." [Tampa, Fla] : University of South Florida, 2009. http://purl.fcla.edu/usf/dc/et/SFE0002823.

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Kashpur, Olga. "Oxygen-mediated basic fibroblast growth factor (FGF2) effects on adult human dermal fibroblasts." Digital WPI, 2015. https://digitalcommons.wpi.edu/etd-dissertations/546.

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This thesis investigates the effects of low oxygen culture conditions and fibroblast growth factor-2 (FGF2) on adult human dermal fibroblasts. It was previously shown that low oxygen and FGF2 culture conditions lead to an extension of proliferative lifespan, low-level activation of stem cell genes, and global transcriptional changes in adult human dermal fibroblasts. Additionally, an increased in vivo tissue regenerative response can be observed when human muscle-derived fibroblasts grown with FGF2 and low oxygen are implanted into mouse muscle injury, leading to a decrease in collagen deposit

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Merle, Pierre-Laurent. "Effets du facteur de croissance basique des fibroplastes (FGF-2) sur la perméabilité membranaire et l'homéostasie calcique de cardiomyocytes de rats." Université Joseph Fourier (Grenoble), 1997. http://www.theses.fr/1997GRE10126.

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Le facteur de croissance basique des fibroblastes (fgf-2) participe au developpement embryonnaire des cardiomyocytes et semble etre implique dans l'hypertrophie des cardiomyocytes adultes. Dans differents types cellulaires, les cascades d'activation initiees par les facteurs de croissance passent par une elevation de la concentration intracellulaire en calcium. L'objectif de ce travail a ete d'etudier les effets du fgf-2 sur l'homeostasie calcique de cardiomyocytes de ventricules de rats nouveau-nes et adultes. Nous avons montre que les cardiomyocytes de rats nouveau-nes expriment des recepteu

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Prabhudesai, Shirish G. "Fibroblast growth factor-2, chemoresistance and colorectal cancer." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/10163.

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Introduction: The role of fibroblast growth factor-2 (FGF-2) on colorectal cancer (CRC) cells exposed to chemotherapy has not been studied extensively. This thesis investigated whether FGF-2 mediates chemoresistance in primary (SW480) and metastatic (SW620) colon adenocarcinoma cell lines. Methods: Proliferation assays were used to assess the response of SW480 and SW620 colon cancer cell lines to varying concentrations of FGF-2 and to optimise the dose of 5- FU at which 50% cell death was observed. Cell survival assays were performed following 96 hours exposure to 5-FU ± FGF-2. Levels of chemo

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Rennel, Emma. "Molecular Mechanisms in Endothelial Cell Differentiation." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4059.

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Shi-Lu, Chia. "The role of fibroblast growth factor-2 in articular cartilage degradation." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501425.

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Osteoarthritis (OA) is the most common form of joint disease and a leading cause of physical disability woridwide. Cartilage degradation in OA is due to an imbalance between synthesis and degradation of the extracellular matrix. Recent work from our laboratory has shown that the heparin-binding growth factor fibroblast growth factor2 (FGF-2) mediates key responses in cartilage following mechanical trauma and loading. It has also been shown that FGF-2 is localised within the pericellular matrix, attached to the heparan sulphate proteoglycan perlecan. The spatial modulator of chondrocyte functio

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Vailes, McCauley T. "Post-Transfer Outcomes in Cultured Bovine Embryos Supplemented with Epidermal Growth Factor, Fibroblast Growth Factor 2, and Insulin-Like Growth Factor 1." Thesis, Virginia Tech, 2017. http://hdl.handle.net/10919/86273.

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The high incidence of pregnancy loss is a major issue facing the cattle industry. Use of in vitro fertilized (IVF) bovine embryos has become increasingly popular to help alleviate several of these reproductive issues and provide a means to enhance genetic gain for production traits. An uterine paracrine factor cocktail containing epidermal growth factor (EGF), fibroblast growth factor 2 (FGF2), and insulin-like growth factor 1 (IGF1) (collectively termed EFI) was recently identified as a means for improving in vitro derived bovine embryo development and trophectoderm cell numbers. The objectiv

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Dinsdale, Jennifer Anne. "In vivo effects of fibroblast growth factor - 2 on oligodendrocytes and myelin." Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407573.

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Hannocks, Melanie-Jane. "The effects of fibroblast growth factor-2 om human bone marrow cells." Doctoral thesis, University of Cape Town, 2003. http://hdl.handle.net/11427/2836.

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43

HOUSE, STACEY LYNN. "ROLE OF FIBROBLAST GROWTH FACTOR 2 IN CARDIAC ISCHEMIA-REPERFUSION INJURY AND HYPERTROPHY." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1132336027.

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Cha, Jiyoung Der Channing J. "The role and mechanism of fibroblast growth factor receptor 2 in cellular transformation." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1513.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Sep. 16, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Pharmacology." Discipline: Pharmacology; Department/School: Medicine.

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Fletcher, Michael. "Network analysis of fibroblast growth factor receptor 2-regulated gene expression in breast cancer." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608087.

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Moatacim-Berrada, Saadia. "Effet in vitro d'un dextrane biofonctionnel sur la croissance et l'expression du phénotype de l'ostéoblaste humain : modulation par le Fibroblast-Growth-Factor (FGF2)." Bordeaux 2, 1993. http://www.theses.fr/1993BOR28230.

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47

Henry, Rebecca Ann. "The effect of AAV1/2 mediated delivery of brain-derived neurotrophic factor and fibroblast growth factor-2 on adult rodent neurogenesis." Thesis, University of Auckland, 2007. http://hdl.handle.net/2292/1492.

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Neurogenesis is the process by which functionally integrated neurons are generated from progenitor cells. In the adult mammalian brain two sites of high density cell division have been identified that contain neural progenitor cells retaining the ability to generate new neurons: the subgranular zone of the hippocampus (SGZ) and the subventricular zone (SVZ) lining the lateral ventricles in the forebrain. Several studies have suggested that SVZ neural progenitor cells in the adult brain can migrate into regions other than the olfactory bulb after either administration of growth factors, indu

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48

Böhm, Friederike. "Cooperative functions of fibroblast growth factor receptors 1 and 2 in liver homeostasis and regeneration /." [S.l.] : [s.n.], 2009. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=18385.

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49

Debiais, Françoise. "Effets et mecanismes d'action du fibroblast growth factor-2 sur les osteoblastes de calvaria humaine." Paris 7, 2000. http://www.theses.fr/2000PA077058.

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Plusieurs arguments laissent penser que le fgf-2 joue un role important dans le controle de la formation osseuse. Cependant, les mecanismes cellulaires et moleculaires par lesquels le fgf-2 peut moduler l'osteogenese sont peu connus. Nous avons etudie les effets de ce facteur de croissance et ses mecanismes d'action en utilisant des cellules osteoblastiques issues de la voute cranienne de nourrissons, constituant un nouveau modele osteogenique recemment developpe dans le laboratoire. Nous avons montre que ces cellules humaines de calvaria expriment les recepteurs fgfr1 et fgfr2 et sont donc de

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50

Sheikh, Farah. "Regulation of the fibroblast growth factor-2 axis in cardiac cells, effects on cardioprotection and cardiac muscle cell growth." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/NQ62665.pdf.

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