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Journal articles on the topic 'Fiber-OPO'

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Published: 7 July 2024

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1

Hu, Liemao, Yuning Shao, Xinjie Lv, Jian Ning, Gang Zhao, and Shining Zhu. "Performance Studies of High-Power Optical Parametric Oscillators Pumped by a Pulsed Fiber Laser." Applied Sciences 13, no. 13 (June 21, 2023): 7356. http://dx.doi.org/10.3390/app13137356.

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High-power optical parametric oscillators (OPOs), as mature radiation sources in mid-infrared (MIR), degenerate gradually with wavelength increase, mainly above 3700 nm. Using a periodically poled magnesium-oxide-doped lithium niobate (MgO:PPLN) as the nonlinear crystal, we build a high-power signal-resonant OPO pumped by ytterbium-doped fiber laser (YDFL). To improve the OPO’s output power at ~3.8 μm, the parameters, such as the pump beam’s waist diameter and location, the curvature radius of the output coupler and the length of MgO:PPLN, are discussed in detail. When pump power is 79 ± 4 W with a repetition rate of 200 kHz, the OPO provides up to 8 ± 0.4 W average power in beam quality with M2 factors of ~1.84 and ~1.69 in the two axes. Under the highest output power, the center wavelength of the idler beam is 3768.4 nm with a full-width at half-maximum (FWHM) bandwidth of ~18.6 nm. When the output power reaches ~6.3 W, its power stability is 1.6% root mean square (RMS) over 7 h. Further analysis of the factors affecting OPO’s performance and simple structure are critically essential for compact OPO prototypes with a capacity of high output power.

2

Allan, Ewan, Craig Ballantine, Sebastian C. Robarts, David Bajek, and Richard A. McCracken. "Modelling Dispersion Compensation in a Cascaded-Fiber-Feedback Optical Parametric Oscillator." Optics 2, no. 2 (May 28, 2021): 96–102. http://dx.doi.org/10.3390/opt2020010.

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Fiber-feedback optical parametric oscillators (OPOs) incorporate intracavity fibers to provide a compact high-energy wavelength-tunable laser platform; however, dispersive effects can limit operation to the sub-picosecond regime. In this research article, we modeled pulse propagation through systems of cascaded fibers, incorporating SMF-28 and ultra-high numerical aperture (UHNA) fibers with complementary second-order dispersion coefficients. We found that the pulse duration upon exiting the fiber system is dominated by uncompensated third-order effects, with UHNA7 presenting the best opportunity to realise a cascaded-fiber-feedback OPO.

3

Lin, S. T., Y. Y. Lin, R. Y. Tu, T. D. Wang, and Y. C. Huang. "Fiber-laser-pumped CW OPO for Red, Green, Blue Laser Generation." Optics Express 18, no. 3 (January 21, 2010): 2361. http://dx.doi.org/10.1364/oe.18.002361.

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4

Wang, Kaifeng, Xiao Li, Peng Wang, Weihong Hua, Zefeng Wang, and Kai Han. "Broadband, Continuous-Wave, Mid-Infrared Generation Based on ASE Fiber Source." Photonics 9, no. 10 (October 5, 2022): 724. http://dx.doi.org/10.3390/photonics9100724.

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The research reports broadband, continuous-wave (CW), mid-infrared generation based on an optical parametric oscillator (OPO), pumped by an amplified spontaneous emission (ASE) fiber source. The ASE fiber source has a ytterbium (Yb)-doped fiber master oscillator power amplifier (MOPA) structure. By injecting another fiber laser with high power and a narrow linewidth into the nonlinear crystal, the phase-matching difference frequency generation (DFG) can be realized at a low pumping threshold. It is shown that during the down-conversion of the ASE fiber source, the intracavity DFG can steadily and effectively generate a broadband mid-infrared laser, with a central wavelength of 3713 nm. The bandwidth of the mid-infrared laser is 122 nm. The pump power of 2 W generates a 0.238 W mid-infrared laser with a pump-idler conversion efficiency of 11.6%. It has tremendous application potential in the research of broadband CW mid-infrared lasers.

5

Henderson, Angus, and Ryan Stafford. "Low threshold, singly-resonant CW OPO pumped by an all-fiber pump source." Optics Express 14, no. 2 (2006): 767. http://dx.doi.org/10.1364/opex.14.000767.

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6

Cao, Jianjun, Dongyi Shen, Yuanlin Zheng, Yaming Feng, Yan Kong, and Wenjie Wan. "Femtosecond OPO based on MgO:PPLN synchronously pumped by a 532 nm fiber laser." Laser Physics 27, no. 5 (March 23, 2017): 055402. http://dx.doi.org/10.1088/1555-6611/aa637b.

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7

Ren, Tingwei, Chunting Wu, Yongji Yu, Tongyu Dai, Fei Chen, and Qikun Pan. "Development Progress of 3–5 μm Mid-Infrared Lasers: OPO, Solid-State and Fiber Laser." Applied Sciences 11, no. 23 (December 3, 2021): 11451. http://dx.doi.org/10.3390/app112311451.

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A 3–5 μm mid-infrared band is a good window for atmospheric transmission. It has the advantages of high contrast and strong penetration under high humidity conditions. Therefore, it has important applications in the fields of laser medicine, laser radar, environmental monitoring, remote sensing, molecular spectroscopy, industrial processing, space communication and photoelectric confrontation. In this paper, the application background of mid-infrared laser is summarized. The ways to realize mid-infrared laser output are described by optical parametric oscillation, mid-infrared solid-state laser doped with different active ions and fiber laser doped with different rare earth ions. The advantages and disadvantages of various mid-infrared lasers are briefly described. The technical approaches, schemes and research status of mid-infrared lasers are introduced.

8

Leindecker, Nick, Alireza Marandi, Robert L. Byer, Konstantin L. Vodopyanov, Jie Jiang, Ingmar Hartl, Martin Fermann, and Peter G. Schunemann. "Octave-spanning ultrafast OPO with 26-61µm instantaneous bandwidth pumped by femtosecond Tm-fiber laser." Optics Express 20, no. 7 (March 13, 2012): 7046. http://dx.doi.org/10.1364/oe.20.007046.

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9

Zhong, Kai, Jian-quan Yao, De-gang Xu, Yu-ye Wang, and Peng Wang. "A low-threshold efficient KTA OPO by a fiber-coupled diode-end-pumped Nd:YVO4 laser." Optoelectronics Letters 6, no. 6 (November 2010): 412–16. http://dx.doi.org/10.1007/s11801-010-0078-4.

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10

Mahnke, Peter, Peter Peuser, and Philipp Huke. "Nd:YAG laser/KTiOAsO4 (KTA) OPO system for laser ultrasound measurements on carbon-fiber-reinforced composite materials." Applied Physics B 116, no. 2 (January 7, 2014): 333–38. http://dx.doi.org/10.1007/s00340-013-5696-7.

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11

Schneider, Julian, Patrick Forster, Clément Romano, Marc Eichhorn, and Christelle Kieleck. "High pulse energy ZnGeP2 OPO directly pumped by a Q-switched Tm3+-doped single-oscillator fiber laser." Optics Letters 46, no. 9 (April 26, 2021): 2139. http://dx.doi.org/10.1364/ol.422702.

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12

Kieleck, Christelle, Antoine Berrou, Brenda Donelan, Benoit Cadier, Thierry Robin, and Marc Eichhorn. "65 W ZnGeP_2 OPO directly pumped by a Q-switched Tm^3+-doped single-oscillator fiber laser." Optics Letters 40, no. 6 (March 12, 2015): 1101. http://dx.doi.org/10.1364/ol.40.001101.

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13

Freysz, Valerian, and Eric Freysz. "Femtosecond OPO pumped by a high power ytterbium rod-type fiber laser mode locked at harmonic repetition rates." EPJ Web of Conferences 267 (2022): 02040. http://dx.doi.org/10.1051/epjconf/202226702040.

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14

Valerian, Freysz, and Freysz Eric. "Femtosecond OPO pumped by a high power ytterbium rod-type fiber laser mode locked at harmonic repetition rates." Optics & Laser Technology 148 (April 2022): 107750. http://dx.doi.org/10.1016/j.optlastec.2021.107750.

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15

Cleff, C., J. Epping, P. Gross, and C. Fallnich. "Femtosecond OPO based on LBO pumped by a frequency-doubled Yb-fiber laser-amplifier system for CARS spectroscopy." Applied Physics B 103, no. 4 (February 26, 2011): 795–800. http://dx.doi.org/10.1007/s00340-011-4465-8.

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16

Cassis, L. A., J. Yates, W. C. Symons, and R. A. Lodder. "Cardiovascular Near-Infrared Imaging." Journal of Near Infrared Spectroscopy 6, A (January 1998): A21—A25. http://dx.doi.org/10.1255/jnirs.162.

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This research uses near-infrared spectrometric imaging to nondestructively locate and determine Low-Density Lipoprotein (LDL) cholesterol that may serve as an in vivo marker for vulnerable atherosclerotic plaques. Vulnerable plaques are plaques prone, in the presence of an appropriate trigger, to events such as ulceration, rupture, erosion, or thrombus that can lead to an acute syndrome. A Nd:YAG-pumped KTP/OPO tunable near-infrared (NIR) laser system is used as a light source for the fiber-optic catheters employed in this research. The BEST algorithm is used to construct chemical-composition images of the intima of the aorta in test subjects in vivo. The long-term goal of these studies is to use NIR laser spectrometric assays of plaque performed with cardiac catheters in vivo to facilitate assignment of patients to specific drug or surgical interventions selected to match their individual vulnerable plaque characteristics.

17

Feng, Jiacheng, Xi Cheng, Xiao Li, Peng Wang, Weihong Hua, and Kai Han. "Highly Efficient Mid-Infrared Generation from Low-Power Single-Frequency Fiber Laser Using Phase-Matched Intracavity Difference Frequency Mixing." Applied Sciences 10, no. 21 (October 23, 2020): 7454. http://dx.doi.org/10.3390/app10217454.

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In this paper, we demonstrated efficient mid-infrared generation using a low-power 1064 nm single-frequency (SF) fiber laser based on phase-matched intracavity difference frequency generation (DFG) in a continuous-wave (CW) periodically poled lithium niobate (PPLN)-based optical parametric oscillator (OPO). This is the first time that the frequency down conversion of a low-power SF light source has been achieved using intracavity difference frequency mixing. A high power 1018 nm fiber laser was firstly used for building the parametric oscillation and providing the high power resonant signal wave. To realize an efficient DFG process between the SF pump wave and the intracavity signal wave, the temperature of periodically poled lithium niobate (PPLN) crystal was properly adjusted to satisfy the phase-matching conditions. Finally, the low-power 1064 nm SF pump wave was successfully converted to a 3.7 μm mid-infrared wave with a conversion efficiency of 21.6%. The conversion efficiency, to the best of our knowledge, is the highest for SF lasers in DFG processes. Meanwhile, taking advantage of SF laser pumping, a narrow linewidth of 271 pm (5.9 GHz) in the mid-infrared region was achieved without adding any etalons or devices in the cavity.

18

Yang, Wenlong, Ang Li, Yuanzhen Suo, Fa-Ke Lu, and X. Sunney Xie. "Simultaneous two-color stimulated Raman scattering microscopy by adding a fiber amplifier to a 2 ps OPO-based SRS microscope." Optics Letters 42, no. 3 (January 27, 2017): 523. http://dx.doi.org/10.1364/ol.42.000523.

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19

Grzegorczyk, Adrian, and Marcin Mamajek. "A 70 W thulium-doped all-fiber laser operating at 1940 nm." Photonics Letters of Poland 11, no. 3 (September 30, 2019): 81. http://dx.doi.org/10.4302/plp.v11i3.928.

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An all-fiber thulium-doped fiber laser operating at a wavelength of 1940 nm is reported. A maximum output continuous-wave power of 70.7 W with a slope efficiency of 59%, determined with respect to the absorbed pump power, was demonstrated. The laser delivered almost a single-mode beam with a beam quality factor of < 1.3.Full Text: PDF ReferencesM. N. Zervas and C. A. Codemard, "High Power Fiber Lasers: A Review", IEEE J. Sel. Top. Quantum Electron. 20, 0904123 (2014). CrossRef D. J. Richardson, J. Nilsson, and W. A. Clarkson. "High power fiber lasers: current status and future perspectives [Invited]", J. Opt. Soc. Am. B 27, B63 (2010). CrossRef J. Swiderski, A. Zajac, and M. Skorczakowski, "Pulsed ytterbium-doped large mode area double-clad fiber amplifier in MOFPA configuration", Opto-Electron. Rev. 15, 98 (2007). CrossRef M. Eckerle et al. "High-average-power actively-modelocked Tm3+ fiber lasers", Proc. SPIE 8237, 823740 (2012). CrossRef J. Swiderski, D. Dorosz, M. Skorczakowski, and W. Pichola, "Ytterbium-doped fiber amplifier with tunable repetition rate and pulse duration", Laser Phys. 20, 1738 (2010). CrossRef P. Grzes and J. Swiderski, "Gain-Switched 2-μm Fiber Laser System Providing Kilowatt Peak-Power Mode-Locked Resembling Pulses and Its Application to Supercontinuum Generation in Fluoride Fibers", IEEE Phot. J. 10, 1 (2018). CrossRef S. Liang et al. "Transmission of wireless signals using space division multiplexing in few mode fibers", Opt. Express 26, 6490 (2018). CrossRef J. Swiderski, M. Michalska, and P. Grzes, "Broadband and top-flat mid-infrared supercontinuum generation with 3.52 W time-averaged power in a ZBLAN fiber directly pumped by a 2-µm mode-locked fiber laser and amplifier", Appl. Phys. B 124, 152 (2018). CrossRef F. Zhao et al. "Electromagnetically induced polarization grating", Sci. Rep. 8, 16369 (2018). CrossRef J. Sotor et al. "Ultrafast thulium-doped fiber laser mode locked with black phosphorus", Opt. Lett. 40, 3885 (2015). CrossRef M. Olivier et al. "Femtosecond fiber Mamyshev oscillator at 1550 nm", Opt. Lett. 44, 851 (2019). CrossRef J. Swiderski and M. Michalska, "Over three-octave spanning supercontinuum generated in a fluoride fiber pumped by Er & Er:Yb-doped and Tm-doped fiber amplifiers", Opt. Laser Technol. 52, 75 (2013). CrossRef C.Yao et al. "High-power mid-infrared supercontinuum laser source using fluorotellurite fiber", Optica 5, 1264 (2018). CrossRef J. Swiderski and M. Maciejewska, "Watt-level, all-fiber supercontinuum source based on telecom-grade fiber components", Appl. Phys. B 109, 177 (2012). CrossRef O. Traxer and E. X. Keller, "Thulium fiber laser: the new player for kidney stone treatment? A comparison with Holmium:YAG laser", World J. Urol., 1-12 (2019). CrossRef M. Michalska, et al. "Highly stable, efficient Tm-doped fiber laser—a potential scalpel for low invasive surgery", Laser Phys. Lett. 13, 115101 (2016). CrossRef R. L. Blackmon et al. "Thulium fiber laser ablation of kidney stones using a 50-μm-core silica optical fiber", Opt. Eng., 54, 011004 (2015). CrossRef A. Zajac et al. "Fibre lasers – conditioning constructional and technological", Bull. Pol. Ac.: Tech. 58, 491 (2010). CrossRef C. Guo, D. Shen, J. Long, and F. Wang, "High-power and widely tunable Tm-doped fiber laser at 2 \mu m", Chin. Opt. Lett. 10, 091406 (2012). CrossRef F. Liu et al. "Tandem-pumped, tunable thulium-doped fiber laser in 2.1 μm wavelength region", Opt. Express 27, 8283 (2019). CrossRef H. Ahmad, M. Z. Samion, K. Thambiratnam, and M. Yasin, "Widely Tunable Dual-Wavelength Thulium-doped fiber laser Operating in 1.8-2.0 mm Region", Optik 179, 76 (2019). CrossRef N. M. Fried, "Thulium fiber laser lithotripsy: An in vitro analysis of stone fragmentation using a modulated 110‐watt Thulium fiber laser at 1.94 µm", Lasers Surg. Med. 37, 53 (2005). CrossRef N. M. Fried, "High‐power laser vaporization of the canine prostate using a 110 W Thulium fiber laser at 1.91 μm", Lasers Surg. Med. 36, 52 (2005). CrossRef E. Lippert et al. "Polymers Designed for Laser Applications-Fundamentals and Applications", Proc. SPIE 6397, P639704 (2006). CrossRef N. Dalloz et al. "High power Q-switched Tm3+, Ho3+-codoped 2μm fiber laser and application for direct OPO pumping", Proc. SPIE 10897, 108970J (2019). CrossRef N. J. Ramírez-Martinez, M. Nunez-Velazquez, A. A. Umnikov, and J. K. Sahu, "Highly efficient thulium-doped high-power laser fibers fabricated by MCVD", Opt. Express 27, 196 (2019). CrossRef T. Ehrenreich et al. "1-kW, All-Glass Tm:fiber Laser", Proc. SPIE 7580, 758016 (2010). DirectLink L. Shah et al. "Integrated Tm:fiber MOPA with polarized output and narrow linewidth with 100 W average power", Opt. Express 20, 20558 (2012). CrossRef H. Zhen-Yue, Y. Ping, X. Qi-Rong, L. Qiang, and G. Ma-Li, "227-W output all-fiberized Tm-doped fiber laser at 1908 nm", Chin. Phys. B 23, 104206 (2014). CrossRef

20

Peuser, Peter, Willi Platz, Andreas Fix, Gerhard Ehret, Alexander Meister, Matthias Haag, and Paul Zolichowski. "Compact, passively Q-switched, all-solid-state master oscillator-power amplifier-optical parametric oscillator (MOPA-OPO) system pumped by a fiber-coupled diode laser generating high-brightness, tunable, ultraviolet radiation." Applied Optics 48, no. 19 (June 29, 2009): 3839. http://dx.doi.org/10.1364/ao.48.003839.

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21

DING, JIANWU, BRUCE W. ODOM, ALLEN R. GEIGER, and RICHARD D. RICHMOND. "A COMPACT EYE-SAFE OPO PUMPED BY A Nd:YAG MICROCHIP MOPA." International Journal of High Speed Electronics and Systems 18, no. 02 (June 2008): 483–92. http://dx.doi.org/10.1142/s0129156408005503.

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A compact high peak power eye-safer optical parametric oscillator was constructed by pumping it with a master oscillator power amplifier consisting of a large-mode-area ytterbium doped fiber amplifier and a diode-pumped, passively Q-switched Nd : YAG microchip laser. The master oscillator power amplifier has the maximum output pulse energy of 570 μJ with a 3 nanosecond pulse width and a 3 kHz pulse repetition rate. The compact singly resonating optical parametric oscillator utilized a 50 mm periodically poled Lithium Niobate crystal and generated high peak power 1.5 μm eye-safe laser pulses with more than 140 μJ pulse energy, 3 nanosecond pulse width and 3 kHz repetition rate.

22

Tang Zhao, 唐. 钊., 张钧翔 Zhang Junxiang, 付士杰 Fu Shijie, 白晓磊 Bai Xiaolei, 盛. 泉. Sheng Quan, 史. 伟. Shi Wei, and 姚建铨 Yao Jianquan. "Tunable CW all-fiber optical parametric oscillator based on the multimode interference filter." Infrared and Laser Engineering 48, no. 5 (2019): 520002. http://dx.doi.org/10.3788/irla201948.0520002.

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23

Kempf, Hannes, Andrey Muraviev, Felix Breuning, Peter G. Schunemann, Ron Tenne, Alfred Leitenstorfer, and Konstantin Vodopyanov. "Direct sampling of femtosecond electric-field waveforms from an optical parametric oscillator." APL Photonics 9, no. 3 (March 1, 2024). http://dx.doi.org/10.1063/5.0189059.

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Detecting the electric-field waveform of an optical pulse from the terahertz to the visible spectral domain provides a complete characterization of the average field waveform and holds great potential for quantum optics, time-domain (including frequency-comb) spectroscopy, high-harmonic generation, and attosecond science, to name a few. The field-resolved measurements can be performed using electro-optic sampling, where a laser pulse is characterized through an interaction with another pulse of a much shorter duration. The measured pulse train must consist of identical pulses, including their equal carrier-envelope phase (CEP). Due to the limited coverage of broadband laser gain media, creating CEP-stable pulse trains in the mid-infrared typically requires nonlinear frequency conversion, such as difference frequency generation, optical parametric amplification, or optical rectification. These techniques operate in a single-pass geometry, often limiting efficiency. In this work, we demonstrate field-resolved analysis of the pulses generated in a resonant system, an optical parametric oscillator (OPO). Due to the inherent feedback, this device exhibits a relatively high conversion efficiency at a given level of input power. By electro-optic sampling, we prove that a subharmonic OPO pumped with CEP-stable few-cycle fiber-laser pulses generates a CEP-stable mid-infrared output. The full amplitude and phase information renders dispersion control straightforward. We also confirm the existence of an exotic “flipping” state of the OPO directly in the time domain, where the electric field of consecutive pulses has the opposite sign.

24

Xi, Cheng, Peng Wang, Xiao Li, and Zejin Liu. "Highly efficient continuous-wave mid-infrared generation based on intracavity difference frequency mixing." High Power Laser Science and Engineering 7 (2019). http://dx.doi.org/10.1017/hpl.2019.45.

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We report on a new scheme for efficient continuous-wave (CW) mid-infrared generation using difference frequency generation (DFG) inside a periodically poled lithium niobate (PPLN)-based optical parametric oscillator (OPO). The pump sources were two CW fiber lasers fixed at 1018 nm and 1080 nm. One worked as the assisted laser to build parametric oscillation and generate an oscillating signal beam while the other worked at low power ( ${\leqslant}3~\text{W}$ ) to induce DFG between it and the signal beam. The PPLN temperature was appropriately adjusted to enable OPO and DFG to synchronously meet phase-matching conditions. Finally, both low-power 1018 nm and 1080 nm pump beams were successfully converted to $3.1~\unicode[STIX]{x03BC}\text{m}$ and $3.7~\unicode[STIX]{x03BC}\text{m}$ idler beams, respectively. The conversion efficiencies of the 1018 nm and 1080 nm pumped DFG reached 20% and 15%, respectively, while their slope efficiencies reached 19.6% and 15%. All these data were comparable to the OPOs pumped by themselves and never realized before in traditional CW DFG schemes. The results reveal that high-efficiency frequency down-conversion can be achieved with a low-power near-infrared pump source.

25

Gorbunov, Alexey, Eugene E. Mukhin, Jorge Manuel Munoz Burgos, Dariya Krivoruchko, Konstantin Yu Vukolov, Gleb Kurskiev, and Sergei Tolstyakov. "Laser-induced Quenching Diagnostics of Hydrogen Atoms in Fusion Plasma." Plasma Physics and Controlled Fusion, August 15, 2022. http://dx.doi.org/10.1088/1361-6587/ac89ad.

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Abstract Laser-induced quenching (LIQ) is a new diagnostic technique developed for hydrogen and hydrogen-like ions with degenerate excited states. The technique is proposed to be used for local measurements of hydrogen parameters (density, temperature, velocity distribution etc.) in the scrape-off-layer and divertor plasmas of tokamaks and other fusion devises. The Hα quenching effect was simulated via a dynamic collision-radiative model developed for the hydrogen atom. The model has also been applied to both analyze the performance of various spectroscopic schemes and to evaluate saturation effects and quenching signals. Possibility of the LIQ technique to measure hydrogen density is given as well as electron density from analysis of quenching to fluorescence ratio. Experimental testing was performed in a glow discharge plasma with pulsed wavelength-tunable OPO laser and in Globus-M2 tokamak with time-modulated 1875 nm fiber laser.

26

Kong, Cihang, Christian Pilger, Manuel Kunisch, Christine Förster, Jan Schulte am Esch, and Thomas Huser. "Hyperspectral Coherent Raman Scattering (CRS) Microscopy Based on a Rapidly Tunable and Environmentally Stable Fiber Laser." Laser & Photonics Reviews, September 8, 2023. http://dx.doi.org/10.1002/lpor.202300521.

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AbstractCoherent Raman scattering (CRS) microscopy is an attractive label‐free imaging method providing high chemical sensitivity, sub‐micron spatial resolution, and video‐rate imaging speed. When extended to hyperspectral CRS (HS‐CRS), it is capable of distinguishing molecules even in complex heterogeneous systems by probing multiple Raman resonances. Solid‐state lasers, associated with their high cost, large footprint, and slow tuning speed, currently limit the widespread application of HS‐CRS. Fiber lasers with comparable properties usually suffer from poor noise performance or instabilities during wavelength tuning. A tunable two‐color fiber laser is demonstrated that can be electronically tuned at rates of up to 1 kHz. The use of polarization‐maintaining fibers and an all‐optical synchronization mechanism guarantees its mode‐locking stability. The superior noise performance of this system is evaluated by the side‐by‐side comparison with data obtained by a commercial optical parametric oscillator (OPO)‐based laser. Large‐area multimodal imaging of liver tissue sections surgically resected from a patient suffering from a non‐neoplastic liver parenchyma with micronodular cirrhosis in combination with a multilocular hepatocellular carcinoma is demonstrated. By exploiting the fast‐hyperspectral scanning capability of the laser and multivariate statistical analysis, virtual staining of tissue sections and a comparison of the diagnostic properties of HS‐CRS to the classical histopathological approach are achieved.