Journal articles on the topic 'FFA2'
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Priyadarshini, Medha, Guadalupe Navarro, and Brian T. Layden. "Gut Microbiota: FFAR Reaching Effects on Islets." Endocrinology 159, no. 6 (May 4, 2018): 2495–505. http://dx.doi.org/10.1210/en.2018-00296.
Full textSchmidt, Johannes, Nicola J. Smith, Elisabeth Christiansen, Irina G. Tikhonova, Manuel Grundmann, Brian D. Hudson, Richard J. Ward, et al. "Selective Orthosteric Free Fatty Acid Receptor 2 (FFA2) Agonists." Journal of Biological Chemistry 286, no. 12 (January 10, 2011): 10628–40. http://dx.doi.org/10.1074/jbc.m110.210872.
Full textGough, Sophie, Brian Layden, Chioma Nnyamah, Medha Priyadarshini, Barton Wicksteed, and Kristen Lednovich. "OR23-4 Intestinal FFA2 and FFA3 Mediate Obesogenic Effects in Mice on a Western Diet." Journal of the Endocrine Society 6, Supplement_1 (November 1, 2022): A19. http://dx.doi.org/10.1210/jendso/bvac150.040.
Full textVilla, Stephanie R., Rama K. Mishra, Joseph L. Zapater, Medha Priyadarshini, Annette Gilchrist, Helena Mancebo, Gary E. Schiltz, and Brian T. Layden. "Homology modeling of FFA2 identifies novel agonists that potentiate insulin secretion." Journal of Investigative Medicine 65, no. 8 (August 7, 2017): 1116–24. http://dx.doi.org/10.1136/jim-2017-000523.
Full textBisenieks, Egils, Brigita Vigante, Ramona Petrovska, Baiba Turovska, Ruslan Muhamadejev, Vitalijs Soloduns, Astrida Velena, et al. "The Specificity and Broad Multitarget Properties of Ligands for the Free Fatty Acid Receptors FFA3/GPR41 and FFA2/GPR43 and the Related Hydroxycarboxylic Acid Receptor HCA2/GPR109A." Pharmaceuticals 14, no. 10 (September 28, 2021): 987. http://dx.doi.org/10.3390/ph14100987.
Full textNnyamah, Christine, Barton Wicksteed, and Brian Layden. "PSUN82 The Gut Microbiome Regulates Healthy Adipose Tissue Expansion via the Action of FFA2." Journal of the Endocrine Society 6, Supplement_1 (November 1, 2022): A25. http://dx.doi.org/10.1210/jendso/bvac150.053.
Full textZhang, J., S. Cheng, Y. Wang, X. Yu, and J. Li. "Identification and characterization of the free fatty acid receptor 2 (FFA2) and a novel functional FFA2-like receptor (FFA2L) for short-chain fatty acids in pigs: Evidence for the existence of a duplicated FFA2 gene (FFA2L) in some mammalian species." Domestic Animal Endocrinology 47 (April 2014): 108–18. http://dx.doi.org/10.1016/j.domaniend.2013.10.004.
Full textFuller, Miles, Medha Priyadarshini, Sean M. Gibbons, Anthony R. Angueira, Michael Brodsky, M. Geoffrey Hayes, Petia Kovatcheva-Datchary, et al. "The short-chain fatty acid receptor, FFA2, contributes to gestational glucose homeostasis." American Journal of Physiology-Endocrinology and Metabolism 309, no. 10 (November 15, 2015): E840—E851. http://dx.doi.org/10.1152/ajpendo.00171.2015.
Full textLednovlch, Kristen R., Sophie Gough, Medha Priyadarshini, and Brian Layden. "Tu1952 DEFINING THE ROLE OF INTESTINE-SPECIFIC FFA2 AND FFA3 IN HORMONAL SECRETION." Gastroenterology 158, no. 6 (May 2020): S—1231. http://dx.doi.org/10.1016/s0016-5085(20)33739-2.
Full textKaji, Izumi, Yasutada Akiba, Jonathan D. Kaunitz, Shin-ichiro Karaki, and Atsukazu Kuwahara. "Su1745 Differential Expression of Short-Chain Fatty Acid Receptor FFA2 and FFA3 in Foregut." Gastroenterology 142, no. 5 (May 2012): S—494. http://dx.doi.org/10.1016/s0016-5085(12)61887-3.
Full textMilligan, Graeme, Leigh A. Stoddart, and Nicola J. Smith. "Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3." British Journal of Pharmacology 158, no. 1 (September 2009): 146–53. http://dx.doi.org/10.1111/j.1476-5381.2009.00421.x.
Full textBindels, Laure B., Evelyne M. Dewulf, and Nathalie M. Delzenne. "GPR43/FFA2: physiopathological relevance and therapeutic prospects." Trends in Pharmacological Sciences 34, no. 4 (April 2013): 226–32. http://dx.doi.org/10.1016/j.tips.2013.02.002.
Full textMikami, Daisuke, Mamiko Kobayashi, Junsuke Uwada, Takashi Yazawa, Kazuko Kamiyama, Kazuhisa Nishimori, Yudai Nishikawa, et al. "Short-chain fatty acid mitigates adenine-induced chronic kidney disease via FFA2 and FFA3 pathways." Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1865, no. 6 (June 2020): 158666. http://dx.doi.org/10.1016/j.bbalip.2020.158666.
Full textTang, Cong, Kashan Ahmed, Andreas Gille, Shun Lu, Hermann-Josef Gröne, Sorin Tunaru, and Stefan Offermanns. "Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes." Nature Medicine 21, no. 2 (January 12, 2015): 173–77. http://dx.doi.org/10.1038/nm.3779.
Full textSleeth, Michelle L., Emily L. Thompson, Heather E. Ford, Sagen E. K. Zac-Varghese, and Gary Frost. "Free fatty acid receptor 2 and nutrient sensing: a proposed role for fibre, fermentable carbohydrates and short-chain fatty acids in appetite regulation." Nutrition Research Reviews 23, no. 1 (May 19, 2010): 135–45. http://dx.doi.org/10.1017/s0954422410000089.
Full textSwaminath, Gayathri, Peter Jaeckel, Qi Guo, Mario Cardozo, Jennifer Weiszmann, Richard Lindberg, Yingcai Wang, Ralf Schwandner, and Yang Li. "Mutational analysis of G-protein coupled receptor – FFA2." Biochemical and Biophysical Research Communications 405, no. 1 (February 2011): 122–27. http://dx.doi.org/10.1016/j.bbrc.2010.12.139.
Full textBrown, Andrew J., Christina Tsoulou, Emma Ward, Elaine Gower, Nisha Bhudia, Forhad Chowdhury, Tony W. Dean, Nicolas Faucher, Akanksha Gangar, and Simon J. Dowell. "Pharmacological properties of acid N -thiazolylamide FFA2 agonists." Pharmacology Research & Perspectives 3, no. 3 (May 8, 2015): e00141. http://dx.doi.org/10.1002/prp2.141.
Full textAkiba, Yasutada, Koji Maruta, Kazuyuki Narimatsu, Hyder Said, Izumi Kaji, Ayaka Kuri, Ken-ichi Iwamoto, Atsukazu Kuwahara, and Jonathan D. Kaunitz. "FFA2 activation combined with ulcerogenic COX inhibition induces duodenal mucosal injury via the 5-HT pathway in rats." American Journal of Physiology-Gastrointestinal and Liver Physiology 313, no. 2 (August 1, 2017): G117—G128. http://dx.doi.org/10.1152/ajpgi.00041.2017.
Full textVaziri, Nosratola D., Ane C. F. Nunes, Hyder Said, Mahyar Khazaeli, Han Liu, Yitong Zhao, Wanghui Jing, Kyle Cogburn, Leila Alikhani, and Wei Ling Lau. "Route of intestinal absorption and tissue distribution of iron contained in the novel phosphate binder ferric citrate." Nephrology Dialysis Transplantation 35, no. 7 (June 8, 2020): 1136–44. http://dx.doi.org/10.1093/ndt/gfaa053.
Full textKang, Jisoo, and Dong-Soon Im. "FFA2 Activation Ameliorates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice." Biomolecules & Therapeutics 28, no. 3 (May 1, 2020): 267–71. http://dx.doi.org/10.4062/biomolther.2019.160.
Full textFuller, Miles, Xiaoran Li, Robert Fisch, Moneb Bughara, Barton Wicksteed, Petia Kovatcheva-Datchary, and Brian T. Layden. "FFA2 Contribution to Gestational Glucose Tolerance Is Not Disrupted by Antibiotics." PLOS ONE 11, no. 12 (December 13, 2016): e0167837. http://dx.doi.org/10.1371/journal.pone.0167837.
Full textVanhoutte, F., F. Namour, S. Dupont, W. Haazen, M. Petkova, A. Van der Aa, G. van ‘t Klooster, and J. Beetens. "DOP070 The FFA2 antagonist GLPG0974: opportunity to treat neutrophil-driven inflammation." Journal of Crohn's and Colitis 8 (February 2014): S48. http://dx.doi.org/10.1016/s1873-9946(14)60095-7.
Full textLymperopoulos, Anastasios, Malka S. Suster, and Jordana I. Borges. "Short-Chain Fatty Acid Receptors and Cardiovascular Function." International Journal of Molecular Sciences 23, no. 6 (March 18, 2022): 3303. http://dx.doi.org/10.3390/ijms23063303.
Full textLiu, Jun-Li, Irina Segovia, Xiao-Lin Yuan, and Zu-hua Gao. "Controversial Roles of Gut Microbiota-Derived Short-Chain Fatty Acids (SCFAs) on Pancreatic β-Cell Growth and Insulin Secretion." International Journal of Molecular Sciences 21, no. 3 (January 30, 2020): 910. http://dx.doi.org/10.3390/ijms21030910.
Full textVanhoutte, Frédéric P., Florence S. Namour, Sonia Dupont, Mathieu Pizzonero, Steve De Vos, Laurent Sanière, Annegret van der Aa, Johan Beetens, and Gerben van 't Klooster. "Mo1234 The FFA2 Antagonist GLPG0974: A Promising Approach to Treat Neutrophil-Driven Inflammation." Gastroenterology 146, no. 5 (May 2014): S—593. http://dx.doi.org/10.1016/s0016-5085(14)62149-1.
Full textHudson, Brian D., Irina G. Tikhonova, Sunil K. Pandey, Trond Ulven, and Graeme Milligan. "Extracellular Ionic Locks Determine Variation in Constitutive Activity and Ligand Potency between Species Orthologs of the Free Fatty Acid Receptors FFA2 and FFA3." Journal of Biological Chemistry 287, no. 49 (October 12, 2012): 41195–209. http://dx.doi.org/10.1074/jbc.m112.396259.
Full textFreitas, Raquel D. S., Thaís C. Muradás, Ana Paula A. Dagnino, Fernanda L. Rost, Kesiane M. Costa, Gianina T. Venturin, Samuel Greggio, Jaderson C. da Costa, and Maria M. Campos. "Targeting FFA1 and FFA4 receptors in cancer-induced cachexia." American Journal of Physiology-Endocrinology and Metabolism 319, no. 5 (November 1, 2020): E877—E892. http://dx.doi.org/10.1152/ajpendo.00509.2019.
Full textAl Mahri, Saeed, Shuja Shafi Malik, Maria Al Ibrahim, Esraa Haji, Ghida Dairi, and Sameer Mohammad. "Free Fatty Acid Receptors (FFARs) in Adipose: Physiological Role and Therapeutic Outlook." Cells 11, no. 4 (February 21, 2022): 750. http://dx.doi.org/10.3390/cells11040750.
Full textLee, Taeweon, Ralf Schwandner, Gayathri Swaminath, Jennifer Weiszmann, Mario Cardozo, Joanne Greenberg, Peter Jaeckel, et al. "Identification and Functional Characterization of Allosteric Agonists for the G Protein-Coupled Receptor FFA2." Molecular Pharmacology 74, no. 6 (September 25, 2008): 1599–609. http://dx.doi.org/10.1124/mol.108.049536.
Full textWang, Yingcai, Xianyun Jiao, Frank Kayser, Jiwen Liu, Zhongyu Wang, Malgorzata Wanska, Joanne Greenberg, et al. "The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators." Bioorganic & Medicinal Chemistry Letters 20, no. 2 (January 2010): 493–98. http://dx.doi.org/10.1016/j.bmcl.2009.11.112.
Full textMa, Liang, Taijin Wang, Min Shi, Ping Fu, Heying Pei, and Haoyu Ye. "Synthesis, Activity, and Docking Study of Novel Phenylthiazole-Carboxamido Acid Derivatives as FFA2 Agonists." Chemical Biology & Drug Design 88, no. 1 (February 15, 2016): 26–37. http://dx.doi.org/10.1111/cbdd.12729.
Full textPatti, Angelo Maria, Rosaria Vincenza Giglio, Nikolaos Papanas, Dragos Serban, Anca Pantea Stoian, Kalliopi Pafili, Khalid Al Rasadi, et al. "Experimental and Emerging Free Fatty Acid Receptor Agonists for the Treatment of Type 2 Diabetes." Medicina 58, no. 1 (January 11, 2022): 109. http://dx.doi.org/10.3390/medicina58010109.
Full textGrundmann, Manuel, Eckhard Bender, Jens Schamberger, and Frank Eitner. "Pharmacology of Free Fatty Acid Receptors and Their Allosteric Modulators." International Journal of Molecular Sciences 22, no. 4 (February 10, 2021): 1763. http://dx.doi.org/10.3390/ijms22041763.
Full textAgapay, R. C., A. W. Go, and Y. H. Ju. "Synthesis of symmetrical structured triglycerides via a bottom-up process." IOP Conference Series: Materials Science and Engineering 1195, no. 1 (October 1, 2021): 012017. http://dx.doi.org/10.1088/1757-899x/1195/1/012017.
Full textAkiba, Yasutada, and Jonathan D. Kaunitz. "Su240 ENHANCED FFA2/5-HT MEDIATED ANION SECRETION IN MOUSE DUODENUM – A MODEL OF FUNCTIONAL DYSPEPSIA?" Gastroenterology 160, no. 6 (May 2021): S—650. http://dx.doi.org/10.1016/s0016-5085(21)02265-4.
Full textNamour, Florence, René Galien, Tim Van Kaem, Annegret Van der Aa, Frédéric Vanhoutte, Johan Beetens, and Gerben Klooster. "Safety, pharmacokinetics and pharmacodynamics of GLPG0974, a potent and selective FFA2 antagonist, in healthy male subjects." British Journal of Clinical Pharmacology 82, no. 1 (May 2016): 139–48. http://dx.doi.org/10.1111/bcp.12900.
Full textHansen, Anders Højgaard, Eugenia Sergeev, Sunil K. Pandey, Brian D. Hudson, Elisabeth Christiansen, Graeme Milligan, and Trond Ulven. "Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43)." Journal of Medicinal Chemistry 60, no. 13 (June 16, 2017): 5638–45. http://dx.doi.org/10.1021/acs.jmedchem.7b00338.
Full textMaruta, Koji, Yasutada Akiba, Izumi Kaji, and Jonathan D. Kaunitz. "Serotonin Released by FFA2 Activation Stimulates HCO 3 - Secretion, but Induces Mucosal Injury in Rat Duodenum." Gastroenterology 152, no. 5 (April 2017): S13—S14. http://dx.doi.org/10.1016/s0016-5085(17)30420-1.
Full textSaid, Hyder, Yasutada Akiba, Izumi Kaji, Kazuyuki Narimatsu, and Jonathan D. Kaunitz. "Sa1725 FFA2 Activation Suppresses Basal and Stimulated Gastric Acid Secretion via 5-HT3 Receptor Activation in Rats." Gastroenterology 148, no. 4 (April 2015): S—315. http://dx.doi.org/10.1016/s0016-5085(15)31041-6.
Full textAkiba, Yasutada, Takeshi Takajo, and Jonathan D. Kaunitz. "Mo1171 - Functional Localization of Ffa2 to the Basolateral Membrane of Enterochromaffin Cells in Rat and Mouse Duodenum." Gastroenterology 154, no. 6 (May 2018): S—695. http://dx.doi.org/10.1016/s0016-5085(18)32452-1.
Full textHudson, Brian D., Maria E. Due-Hansen, Elisabeth Christiansen, Anna Mette Hansen, Amanda E. Mackenzie, Hannah Murdoch, Sunil K. Pandey, et al. "Defining the Molecular Basis for the First Potent and Selective Orthosteric Agonists of the FFA2 Free Fatty Acid Receptor." Journal of Biological Chemistry 288, no. 24 (April 15, 2013): 17296–312. http://dx.doi.org/10.1074/jbc.m113.455337.
Full textTang, Gang, Yi Du, Haochen Guan, Jieshuang Jia, Nan Zhu, Yuping Shi, Shu Rong, and Weijie Yuan. "Butyrate ameliorates skeletal muscle atrophy in diabetic nephropathy by enhancing gut barrier function and FFA2‐mediated PI3K/Akt/mTOR signals." British Journal of Pharmacology 179, no. 1 (November 23, 2021): 159–78. http://dx.doi.org/10.1111/bph.15693.
Full textKimura, Ikuo, Atsuhiko Ichimura, Ryuji Ohue-Kitano, and Miki Igarashi. "Free Fatty Acid Receptors in Health and Disease." Physiological Reviews 100, no. 1 (January 1, 2020): 171–210. http://dx.doi.org/10.1152/physrev.00041.2018.
Full textPizzonero, Mathieu, Sonia Dupont, Marielle Babel, Stéphane Beaumont, Natacha Bienvenu, Roland Blanqué, Laëtitia Cherel, et al. "Discovery and Optimization of an Azetidine Chemical Series As a Free Fatty Acid Receptor 2 (FFA2) Antagonist: From Hit to Clinic." Journal of Medicinal Chemistry 57, no. 23 (December 2014): 10044–57. http://dx.doi.org/10.1021/jm5012885.
Full textKaji, Izumi, Shin-ichiro Karaki, Ryo Tanaka, and Atsukazu Kuwahara. "M1718 Fructo-Oligosaccharide (FOS) Supplementation Increases Enteroendocrine L Cells Containing GLP-1 and SCFA Receptor GPR43 (Ffa2) in the Large Intestine." Gastroenterology 138, no. 5 (May 2010): S—405. http://dx.doi.org/10.1016/s0016-5085(10)61861-6.
Full textKytikova, O. Yu, T. P. Novgorodtseva, Yu K. Denisenko, M. V. Antonyuk, and T. A. Gvozdenko. "Medium and long chain free fatty acid receptors in the pathophysiology of respiratory diseases." Bulletin Physiology and Pathology of Respiration, no. 80 (July 16, 2021): 115–28. http://dx.doi.org/10.36604/1998-5029-2021-80-115-128.
Full textVelasco, Cristina, Marta Conde-Sieira, Sara Comesaña, Mauro Chivite, Adrián Díaz-Rúa, Jesús M. Míguez, and José L. Soengas. "The long-chain fatty acid receptors FFA1 and FFA4 are involved in food intake regulation in fish brain." Journal of Experimental Biology 223, no. 17 (July 14, 2020): jeb227330. http://dx.doi.org/10.1242/jeb.227330.
Full textChristiansen, Elisabeth, Kenneth R. Watterson, Claire J. Stocker, Elena Sokol, Laura Jenkins, Katharina Simon, Manuel Grundmann, et al. "Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases." British Journal of Nutrition 113, no. 11 (April 28, 2015): 1677–88. http://dx.doi.org/10.1017/s000711451500118x.
Full textHori, Yasushi, Kazutoshi Nakamura, Masaharu Yamamoto, Kenji Shimada, Hiroto Nakadaira, Norio Shibuya, Kazuo Endoh, and Kazuei Ogoshi. "Determination of Free Fatty Acids in Human Bile by High-Performance Liquid Chromatography." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 35, no. 2 (March 1998): 279–82. http://dx.doi.org/10.1177/000456329803500213.
Full textAlharbi, Abdulrahman G., Andrew B. Tobin, and Graeme Milligan. "How Arrestins and GRKs Regulate the Function of Long Chain Fatty Acid Receptors." International Journal of Molecular Sciences 23, no. 20 (October 13, 2022): 12237. http://dx.doi.org/10.3390/ijms232012237.
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