Journal articles: 'Fetal outcomes'

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Edwards, Morven S. "Adverse Fetal Outcomes." JAMA 311, no. 11 (March 19, 2014): 1115. http://dx.doi.org/10.1001/jama.2014.1889.

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Abbasalizadeh, Fatemeh, Shamsi Abbasalizadeh, Shamsi Ghaffari, Rabee Hesami, and Leyla Hesmai. "Fetal Arrhythmias and Related Fetal and Neonatal Outcomes." International Journal of Women's Health and Reproduction Sciences 4, no. 3 (September 5, 2015): 130–33. http://dx.doi.org/10.15296/ijwhr.2016.30.

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Camargo, Sávio F., Juliana D. Camargo, Daniel Schwade, Raíssa M. Silva, Maria da Conceição M. Cornetta, Ricardo N. Cobucci, and Eduardo C. Costa. "Movement Behavior during Pregnancy and Adverse Maternal–Fetal Outcomes in Women with Gestational Diabetes: A Pilot Case-Control Study." International Journal of Environmental Research and Public Health 18, no. 3 (January 27, 2021): 1114. http://dx.doi.org/10.3390/ijerph18031114.

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Gestational diabetes mellitus (GDM) is a major complication in pregnancy. GDM is associated with a higher risk for adverse maternal–fetal outcomes. Associations between movement behavior, including physical activity (PA) and sedentary behavior (SB), and maternal–fetal outcomes are still unclear. The objective of this study was to investigate associations between movement behavior and adverse maternal–fetal outcomes in women with GDM. A total of 68 women with GDM (20–35 weeks, 32.1 ± 5.8 years) were included in this pilot case-control study. The cases were defined by the presence of an adverse composite maternal–fetal outcome (preterm birth, newborn large for gestational age, and neonatal hypoglycemia). Controls were defined as no adverse maternal–fetal outcome. PA intensities and domains, steps/day (pedometer), and SB were analyzed. A total of 35.3% of participants showed adverse maternal–fetal outcomes (n = 24). The controls showed a higher moderate-intensity PA level than the cases (7.5, 95%CI 3.6–22.9 vs. 3.1, 95%CI 0.4–10.3 MET-h/week; p = 0.04). The moderate-intensity PA level was associated with a lower risk for adverse maternal–fetal outcomes (OR 0.21, 95%CI 0.05–0.91). No significant associations were observed for other PA and SB measures (p > 0.05). In conclusion, moderate-intensity PA during pregnancy seems to have a protective role against adverse maternal–fetal outcomes in women with GDM.

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Ge, Christina J., Amanda C. Mahle, Irina Burd, Eric B. Jelin, Priya Sekar, and Angie C. Jelin. "Fetal CHD and perinatal outcomes." Cardiology in the Young 30, no. 5 (April 20, 2020): 686–91. http://dx.doi.org/10.1017/s1047951120000785.

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AbstractObjective:To evaluate delivery management and outcomes in fetuses prenatally diagnosed with CHD.Study design:A retrospective cohort study was conducted on 6194 fetuses (born between 2013 and 2016), comparing prenatally diagnosed with CHD (170) to those with non-cardiac (234) and no anomalies (5790). Primary outcomes included the incidence of preterm delivery and mode of delivery.Results:Gestational age at delivery was significantly lower between the CHD and non-anomalous cohorts (38.6 and 39.1 weeks, respectively). Neonates with CHD had a significantly lower birth weights (p < 0.001). There was an approximately 1.5-fold increase in the rate of primary cesarean sections associated with prenatally diagnosed CHD with an odds ratio of 1.49 (95% CI 1.06–2.10).Conclusions:Our study provides additional evidence that the prenatal diagnosis of CHD is associated with a lower birth weight, preterm delivery, and with an increased risk of delivery by primary cesarean section.

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Fanaroff, A. A. "Fetal macrosomia and pregnancy outcomes." Yearbook of Neonatal and Perinatal Medicine 2010 (January 2010): 15–16. http://dx.doi.org/10.1016/s8756-5005(10)79203-9.

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Carney, Ellen F. "Fetal growth and renal outcomes." Nature Reviews Nephrology 10, no. 7 (May 27, 2014): 361. http://dx.doi.org/10.1038/nrneph.2014.97.

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Ju, H., Y. Chadha, T. Donovan, and P. OʼRourke. "Fetal Macrosomia and Pregnancy Outcomes." Obstetric Anesthesia Digest 30, no. 4 (December 2010): 231–32. http://dx.doi.org/10.1097/01.aoa.0000389609.94004.12.

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HOFFMAN, MATTHEW K., AUDREY A. MERRIAM, and DEBORAH B. EHRENTHAL. "Fetal Outcomes of Elective Delivery." Clinical Obstetrics and Gynecology 57, no. 2 (June 2014): 401–14. http://dx.doi.org/10.1097/grf.0000000000000030.

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JU, Hong, Yogesh CHADHA, Tim DONOVAN, and Peter O’ROURKE. "Fetal macrosomia and pregnancy outcomes." Australian and New Zealand Journal of Obstetrics and Gynaecology 49, no. 5 (October 2009): 504–9. http://dx.doi.org/10.1111/j.1479-828x.2009.01052.x.

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More, Vibha S. "Fever in pregnancy and its maternal and fetal outcomes." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 12 (November 23, 2017): 5523. http://dx.doi.org/10.18203/2320-1770.ijrcog20175273.

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Background: Contemporary obstetrics has witnessed improved maternal and fetal outcomes, owing to several advances. Any source of maternal hyperthermia that results in significant core temperature increase (>38.9°C), could potentially affect the fetus. Hence a study was planned to know the effect of fever on maternal and fetal outcome.Methods: This was a retrospective cohort analysis of case-records, of patients admitted in the Department of Obstetrics and Gynecology at tertiary care centre, Mumbai, between May 2007 and October 2009. The main parameters of assessment included incidence of fever in pregnancy, causes of fever, effect of episode(s) of fever on maternal and fetal outcomes, effect of specific infection on maternal and fetal outcomes, impact of fever on antepartum, intrapartum and postpartum phasesResults: The incidence of fever was 10.5%. the common cause of fever was malaria (15%), urinary tract infection (14%), viral (14%), respiratory tract infection (18%), and typhoid (7%). Seventy eight percent had fever in third trimester. The most common antenatal complication observed was preterm (13%), premature rupture of membrane (12%), oligohydramnios (8%), intrauterine growth retardation (26%). The rate of LSCS was 13% in study group and the most common indication was fetal distress and meconium stained amniotic fluid.Conclusions: In the present study on fever during pregnancy and its maternal and fetal outcomes, fever was associated with a definite impact on maternal and fetal outcomes. Preterm and IUGR were the most common fetal complications. Duration of fever was linearly associated with poor outcomes. Different causes of fever also had different impact on maternal and fetal outcome. Preterm IUGR, MSAF were more common with malaria and tuberculosis. Abortion was more commonly seen in first trimester fever, whereas preterm, PROM in the third trimester fever. Hence it is suggested that fever during pregnancy needs to be promptly investigated and treated to have a better outcome.

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Rajan, Sudha J., Sowmya Sathyendra, and Alice J. Mathuram. "Scrub typhus in pregnancy: Maternal and fetal outcomes." Obstetric Medicine 9, no. 4 (June 21, 2016): 164–66. http://dx.doi.org/10.1177/1753495x16638952.

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Scrub typhus is an important unrecognized cause for undifferentiated acute febrile illness in India associated with poor fetal outcomes. Maternal and fetal outcomes among pregnant patients with scrub typhus presenting to a tertiary care university teaching hospital from January 2010 to July 2012 were studied. Scrub typhus was diagnosed by clinical criteria along with scrub ELISA positivity or an eschar. In total, 33 of 738 patients (4.5%) who were diagnosed with scrub typhus were pregnant; 57.6% were in the third trimester, 27.3% in the second, and only 15.2% in the first trimester; 69.7% required admission to intensive care. Mortality was low (3%, n = 1) compared to 12.2% mortality reported previously. All patients were treated with Azithromycin. Poor fetal outcome was observed in 51.5% of these pregnancies with fetal loss occurring in 42.4% and preterm childbirth in 9.1%. Scrub typhus complicating pregnancy is associated with a poor fetal outcome despite treatment with Azithromycin. A majority require intensive care treatment for survival.

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DAVUTOĞLU, Ebru, Mehmet Aytaç YÜKSEL, Mahmut ÖNCÜL, Şükrü ÇEBİ, and Rıza MADAZLI. "Heart Disease and Pregnancy: Maternal and Fetal Outcomes." Turkiye Klinikleri Journal of Gynecology and Obstetrics 25, no. 2 (2015): 103–10. http://dx.doi.org/10.5336/gynobstet.2014-43155.

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Mehmood, Bushra, Anisa Saleem, Rubina Kausar, and Amna Aslam. "Teenage Pregnancy; Maternal and Fetal Outcomes." Pakistan Journal of Medical and Health Sciences 15, no. 10 (October 30, 2021): 3394–96. http://dx.doi.org/10.53350/pjmhs2115103394.

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Objective: The aim of this study is to determine the adverse adverse maternal and fetal outcomes in teenage pregnant women. Study Design: Randomized controlled trial Place and Duration: Department of Gyne & Obs, Shahida Islam Teaching Hospital Lodhran, during from 15-04-2020 to 31-03-2021. Material and methods: Total one hundred and twenty patients were enrolled in this study. Patients were aged between 14- 40 years. Patients detailed demographics were recorded after taking written consent. Patients were equally divided into two groups I and II. 60 patients of aged between 14-18 years were included in group I and equally patients of aged >18 were included in group II. Frequency of pre-eclampsia, gestational diabetes mellitus and post-partum haemorrhage were calculated. Adverse outcomes among (cesarean section, instrumental delivery,induction of labor and prolong labor, hypertensive disorder) were calculated among both groups. Fetal outcomes Perinatal mortality, Low birth weight, Low Apgar score and NICU admission were observed. Complete data was analyzed by SPSS 22.0 version. Results: Mean age of the patients in group I was 17.88±1.42 years with mean BMI 22.09±4.66 Kg/m2 and in group II mean age was 19.16±8.64 years with mean BMI 23.87±4.57 Kg/m2. Fetal outcomes, perinatal mortality in group I 8 (13.3%) and in group II was 5 (8.3%), low birth weight in group I was among 25 (41.7%) and in group II was 9 (15%), low apgar score in group I was 10 (16.7%) and in group II was 7 (11.7%), 12 (20%) in group I went to NICU admission and 4 (6.7%) patient in group II admitted to NICU. Frequency of pre-eclampsia in group I were high among 27 (45%) patients as compared to group II 13 (21.7%) patients , frequency of gestational diabetes mellitus in group I was among 14 (23.3 %) patients and 5 (8.3%) patients were in group II, post partum haemorrhage was seen in 42 (70%) cases in group I and 23 (38.3%) cases in group II. Conclusion: Delaying intrauterine development and premature neonatal intensive care admissions are also on the rise in this study. Anemia, urinary tract infection, high blood pressure pregnancy, and surgical delivery are all associated with pregnancies in which the mother is a teenager. Keywords: Pre-eclampsia, Partum haemorrhage, Maternal outcome, Fetal outcome

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Alsammani, MohamedAlkhatim, and SalahRoshdy Ahmed. "Fetal and maternal outcomes in pregnancies complicated with fetal macrosomia." North American Journal of Medical Sciences 4, no. 6 (2012): 283. http://dx.doi.org/10.4103/1947-2714.97212.

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Peterson, Erika, Kelly Bennett, Timothy Crombleholme, Allan Fisher, Ruth Goldstein, William Goodnight, Shinjiro Hirose, et al. "817: Perinatal outcomes after fetal resuscitation during fetal MMC closure." American Journal of Obstetrics and Gynecology 222, no. 1 (January 2020): S514—S515. http://dx.doi.org/10.1016/j.ajog.2019.11.832.

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16

Kuper, Spencer, Robin Steele, Rachel Sievert, Alan Tita, Lorie Harper, and Michelle Wang. "Outcomes of Medically Indicated Preterm Births Differ by Indication." American Journal of Perinatology 35, no. 08 (December 29, 2017): 758–63. http://dx.doi.org/10.1055/s-0037-1615792.

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Objective We aim to examine whether outcomes of preterm birth (PTB) are further modified by the indication for delivery. Study Design We performed a retrospective cohort study of all singletons delivered at 23 to 34 weeks from 2011 to 2014. Women were classified by their primary indication for delivery: maternal (preeclampsia) or fetal/obstetric (growth restriction, nonreassuring fetal status, and vaginal bleeding). The primary neonatal outcome was a composite of neonatal death, cord pH <7 or base excess < − 12, 5-minute Apgar ≤3, C-reactive protein during resuscitation, culture-proven sepsis, intraventricular hemorrhage, and necrotizing enterocolitis. Secondary outcomes included the individual components of the primary outcome. Groups were compared using Student's t-test and chi-squared tests. Logistic regression was used to adjust for confounding variables. Results Of 528 women, 395 (74.8%) were delivered for maternal and 133 (25.2%) for fetal/obstetric indications. Compared with those delivered for a maternal indication, those with a fetal/obstetric indication for delivery had an increased risk of the composite neonatal outcome (adjusted odds ratio [AOR]: 1.9, 95% confidence interval [CI]: 1.13–3.21) and acidemia at birth (AOR: 4.2, 95% CI: 1.89–9.55). Conclusion Preterm infants delivered for fetal/obstetric indications have worsened outcomes compared with those delivered for maternal indications. Additional research is needed to further tailor counseling specific to the indication for delivery.

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Ginsberg, Jeffrey S., Jack Hirsh, D. Christoper Turner, Mark N. Levine, and Robert Burrows. "Risks to the Fetus of Anticoagulant Therapy During Pregnancy." Thrombosis and Haemostasis 61, no. 02 (1989): 197–203. http://dx.doi.org/10.1055/s-0038-1646558.

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SummaryThe use of anticoagulants during pregnancy is problematic because of the potential adverse effects to the mother and the fetus. Heparin does not cross the placenta, and thus, it was surprising that a recent report concluded that heparin therapy during pregnancy was as risky as oral anticoagulant therapy. Therefore, we performed a literature review of fetal/infant outcomes following anticoagulant therapy during pregnancy. We examined 186 reports which described fetal/infant outcomes in 1,325 pregnancies associated with anticoagulant therapy. The rates of adverse fetal/infant outcomes including death, prematurity and congenital malformations following treatment with heparin, oral anticoagulants, or both were calculated. The previously described high rate of adverse feta/infant outcomes with heparin- treated patients, could be accounted for by the frequent use of heparin in pregnancies with comorbid conditions independently associated with adverse outcomes and by reports of uncomplicated prematurity. After excluding such pregnancies, outcomes in heparin-treated patients are similar to the normal population.

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Parmar, Kantilal. "A Study Evaluating Morphology of Placenta and Fetal Outcomes in Hypertensive Pregnancies." Indian Journal of Anatomy 7, no. 6 (2018): 626–36. http://dx.doi.org/10.21088/ija.2320.0022.7618.10.

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Joshi, Hrishikesh, Amrita Kishor Jeswani, and Sangeeta Sheetal Desai. "A study of materno-fetal outcomes in cases of jaundice during pregnancy." New Indian Journal of OBGYN 8, no. 2 (February 2022): 209–13. http://dx.doi.org/10.21276/obgyn.2022.8.2.11.

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Woods, D. L., and G. B. Theron. "Addressing poor maternal and fetal outcomes." South African Medical Journal 102, no. 10 (August 24, 2012): 786. http://dx.doi.org/10.7196/samj.6216.

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Kamini, Snigdha, and Dr Krishna Veni Avvaru. "Teenage Pregnancy: Maternal and Fetal Outcomes." IOSR Journal of Dental and Medical Sciences 13, no. 4 (2014): 41–44. http://dx.doi.org/10.9790/0853-13464144.

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Neu, J. "Outcomes of pregnancies with fetal gastroschisis." Yearbook of Neonatal and Perinatal Medicine 2008 (January 2008): 68–69. http://dx.doi.org/10.1016/s8756-5005(08)79252-7.

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Hunt, Summer. "Anxiety Disorders and Maternal/Fetal Outcomes." Nursing for Women's Health 21, no. 6 (December 2017): 424. http://dx.doi.org/10.1016/s1751-4851(17)30306-9.

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TUCKER, MIRIAM E. "Valproate Linked to Poor Fetal Outcomes." Internal Medicine News 39, no. 24 (December 2006): 23. http://dx.doi.org/10.1016/s1097-8690(06)74640-6.

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Taghavi, Kiarash, Caitlin Sharpe, Mark D. Stringer, Jane Zuccollo, and Jay Marlow. "Fetal megacystis: Institutional experience and outcomes." Australian and New Zealand Journal of Obstetrics and Gynaecology 57, no. 6 (July 12, 2017): 636–42. http://dx.doi.org/10.1111/ajo.12655.

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Saha, Esha, Edward William Samuel Mullins, Gowrishankar Paramasivam, Sailesh Kumar, and Lorin Lakasing. "Perinatal outcomes of fetal echogenic bowel." Prenatal Diagnosis 32, no. 8 (May 15, 2012): 758–64. http://dx.doi.org/10.1002/pd.3898.

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Saha, E., G. Paramasivam, E. Mullins, S. Kumar, and L. Lakasing. "Perinatal outcomes of fetal echogenic bowel." Archives of Disease in Childhood - Fetal and Neonatal Edition 96, Supplement 1 (June 1, 2011): Fa57—Fa58. http://dx.doi.org/10.1136/adc.2011.300161.14.

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Santiago-Munoz, Patricia C., Donald D. McIntire, Robert G. Barber, Stephen M. Megison, Diane M. Twickler, and Jodi S. Dashe. "Outcomes of Pregnancies With Fetal Gastroschisis." Obstetrics & Gynecology 110, no. 3 (September 2007): 663–68. http://dx.doi.org/10.1097/01.aog.0000277264.63736.7e.

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Phelps, LeAdelle. "Psychoeducational Outcomes of Fetal Alcohol Syndrome." School Psychology Review 24, no. 2 (June 1, 1995): 200–212. http://dx.doi.org/10.1080/02796015.1995.12085762.

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Aliyu, Muktar H., Hamisu M. Salihu, Louis G. Keith, John E. Ehiri, M. Aminul Islam, and Pauline E. Jolly. "High Parity and Fetal Morbidity Outcomes." Obstetrics & Gynecology 105, no. 5, Part 1 (May 2005): 1045–51. http://dx.doi.org/10.1097/01.aog.0000157444.74674.75.

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Laye, M. R., B. C. Moore, M. A. Kosek, L. K. Bufkin, J. C. Morrison, and J. A. Bofill. "Fetal macrocrania: diagnosis, delivery and outcomes." Journal of Perinatology 29, no. 3 (December 4, 2008): 201–4. http://dx.doi.org/10.1038/jp.2008.196.

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Kalin, Marc, Amy Cochran, Donald Jeff Newport, Bettina Knight, Natalie Morris, Jim Ritchie, Michael Owens, and Zachary Stowe. "S58. Fetal Antidepressant Exposure and Outcomes." Biological Psychiatry 85, no. 10 (May 2019): S319. http://dx.doi.org/10.1016/j.biopsych.2019.03.809.

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Cucco, Carl, Mark A. Osborne, and Luis A. Cibils. "Maternal-fetal outcomes in prolonged pregnancy." American Journal of Obstetrics and Gynecology 161, no. 4 (October 1989): 916–20. http://dx.doi.org/10.1016/0002-9378(89)90751-5.

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Vollmer, Brigitte. "Neurodevelopmental outcomes of fetal growth restriction." Reproductive Toxicology 99 (January 2021): 136. http://dx.doi.org/10.1016/j.reprotox.2020.12.011.

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Harmon, Duncan, Aaron B. Caughey, Methodius G. Tuuli, Sindhu K. Srinivas, Alan T. Tita, and Alison G. Cahill. "33: Fetal position at complete cervical dilation and maternal/fetal outcomes." American Journal of Obstetrics and Gynecology 222, no. 1 (January 2020): S28—S29. http://dx.doi.org/10.1016/j.ajog.2019.11.049.

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Lian, Xingji, Li Fan, Xin Ning, Cong Wang, Yi Lin, Wenfang Chen, Wei Chen, and Xueqing Yu. "History of Adverse Pregnancy on Subsequent Maternal-Fetal Outcomes in Patients with Immunoglobulin A Nephropathy: A Retrospective Cohort Study from a Chinese Single Center." Kidney Diseases 8, no. 2 (December 9, 2021): 160–67. http://dx.doi.org/10.1159/000520586.

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Background: Gestation complications have a recurrence risk and could predispose to each other in the next pregnancy. We aimed to evaluate the relationship between a history of adverse pregnancy and maternal-fetal outcomes in subsequent pregnancy in patients with Immunoglobulin A nephropathy (IgAN). Methods: A retrospective cohort study from a Chinese single center was conducted. Pregnant women with biopsy-proven primary IgAN and aged ≥18 years were enrolled and divided into the 2 groups by a history of adverse pregnancy. The primary outcome was adverse pregnancy outcome, which included maternal-fetal outcomes. Logistical regression model was used to evaluate the association of a history of adverse pregnancy with subsequent adverse maternal and fetal outcomes. Results: Ninety-one women with 100 pregnancies were included, of which 54 (54%) pregnancies had a history of adverse pregnancy. IgAN patients with adverse pregnancy history had more composite maternal outcomes (70.4% vs. 45.7%, p = 0.012), while there was no difference in the composite adverse fetal outcomes between the 2 groups (55.6% vs. 45.7%). IgAN patients with a history of adverse pregnancy were associated with an increased risk of subsequent adverse maternal outcomes (adjusted odds ratio [OR], 2.64; 95% CI, 1.07–6.47). Similar results were shown in those with baseline serum albumin <3.5 g/dL, 24 h proteinuria ≥1 g/day, and a history of hypertension. There was no association between a history of adverse pregnancy and subsequent adverse fetal outcomes in IgAN patients (adjusted OR, 1.56; 95% CI, 0.63–3.87). Conclusion: A history of adverse pregnancy was associated with an increased risk of subsequent adverse maternal outcomes, but not for adverse fetal outcomes in IgAN patients.

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Sadhwani, Anjali, David Wypij, Valerie Rofeberg, Ali Gholipour, Maggie Mittleman, Julia Rohde, Clemente Velasco-Annis, et al. "Fetal Brain Volume Predicts Neurodevelopment in Congenital Heart Disease." Circulation 145, no. 15 (April 12, 2022): 1108–19. http://dx.doi.org/10.1161/circulationaha.121.056305.

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Background: Neurodevelopmental impairment is common in children with congenital heart disease (CHD), but postnatal variables explain only 30% of the variance in outcomes. To explore whether the antecedents for neurodevelopmental disabilities might begin in utero, we analyzed whether fetal brain volume predicted subsequent neurodevelopmental outcome in children with CHD. Methods: Fetuses with isolated CHD and sociodemographically comparable healthy control fetuses underwent fetal brain magnetic resonance imaging and 2-year neurodevelopmental evaluation with the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III) and the Adaptive Behavior Assessment System, Third Edition (ABAS-3). Hierarchical regression evaluated potential predictors of Bayley-III and ABAS-3 outcomes in the CHD group, including fetal total brain volume adjusted for gestational age and sex, sociodemographic characteristics, birth measures, and medical history. Results: The CHD group (n=52) had lower Bayley-III cognitive, language, and motor scores than the control group (n=26), but fetal brain volumes were similar. Within the CHD group, larger fetal total brain volume correlated with higher Bayley-III cognitive, language, and motor scores and ABAS-3 adaptive functioning scores ( r =0.32–0.47; all P <0.05), but this was not noted in the control group. Fetal brain volume predicted 10% to 21% of the variance in neurodevelopmental outcome measures in univariate analyses. Multivariable models that also included social class and postnatal factors explained 18% to 45% of the variance in outcome, depending on developmental domain. Moreover, in final multivariable models, fetal brain volume was the most consistent predictor of neurodevelopmental outcome across domains. Conclusions: Small fetal brain volume is a strong independent predictor of 2-year neurodevelopmental outcomes and may be an important imaging biomarker of future neurodevelopmental risk in CHD. Future studies are needed to support this hypothesis. Our findings support inclusion of fetal brain volume in risk stratification models and as a possible outcome in fetal neuroprotective intervention studies.

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Maswime,, Salome, Caroline Pule,, Zama Mtshali,, Richard Chawana,, and Mushi Matjila. "HIV, Placental Lesions, and Adverse Perinatal Outcomes." Journal of Infectious Diseases 224, Supplement_6 (December 1, 2021): S691—S693. http://dx.doi.org/10.1093/infdis/jiab494.

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Abstract Africa has the highest number of pregnant women with human immunodeficiency virus (HIV). In some studies, HIV has been associated with adverse perinatal outcomes. However, the pathophysiological mechanism leading to adverse fetal outcomes is not known. Maternal vascular malformation, chorioamnionitis, and decreased placental weight have been described as placental features associated with HIV in some studies. The use of antiretroviral therapy has reduced perinatal transmission of HIV and adverse fetal outcomes. However, placental mechanisms associated with HIV and the fetal immune response to maternal HIV infection are poorly understood. Additional research is required to understand whether altered maternal immunity in women living with HIV can trigger fetal responses leading to stillbirth or preterm birth.

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Sotiros, Alexandra, Dianne Thornhill, Miriam D. Post, Virginia D. Winn, and Jennifer Armstrong. "Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers." PLOS ONE 16, no. 11 (November 15, 2021): e0260094. http://dx.doi.org/10.1371/journal.pone.0260094.

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Preeclampsia is both a vascular and inflammatory disorder. Since the placenta is a conduit for fetal development, preeclampsia should be a presumed cause of adverse infant outcomes. Yet, the relationship of placental pathology, inflammation and neurological outcomes after preeclampsia are understudied. We prospectively examined a cohort of maternal-infant dyads with preeclampsia for maternal inflammatory cytokines at time of preeclampsia diagnosis and delivery, and fetal cord blood cytokines (IL-1β, IL-6, IL-8, and TNF-α). Placentas were analyzed for inflammatory and vascular pathologies. Neurodevelopmental assessment of infants utilizing the Pediatric Stroke Outcome Measure (PSOM) was conducted at 6-month corrected gestational age. Eighty-one maternal-newborn dyads were examined. Worse neurological outcomes were not associated with elevated maternal / fetal cytokines. Early preterm birth (gestational age ≤ 32 weeks) was associated with worse neurological outcomes at 6-months regardless of maternal/ fetal cytokine levels, placental pathology, or cranial ultrasound findings (OR 1.70, [1.16–2.48], p = 0.006). When correcting for gestational age, elevated IL-6 approached significance as a predictor for worse developmental outcome (OR 1.025 [0.985–1.066], p = 0.221). Pathological evidence of maternal malperfusion and worse outcomes were noted in early preterm, although our sample size was small. Our study did not demonstrate an obvious association of inflammation and placental pathology in preeclampsia and adverse neurodevelopmental outcome at 6-month corrected age but does suggest maternal malperfusion at earlier gestational age may be a risk factor for worse outcome.

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Alba, P., Y. Tissera, N. Cucchiaro, V. Savio, R. Serrano Morales, M. I. Quaglia, J. A. Albiero, et al. "AB0338 PREGNANCY OUTCOMES IN ADOLESCENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 1194.1–1194. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3658.

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Background:Systemic lupus erythematosus (SLE) is a autoimmune disease that affects adolescents and young women of childbearing age. In spite of the improvement in fetal and maternal SLE pregnancy outcome in the last decades, they have increased risk of adverse outcomes including disease flare, abortions, preeclampsia (PE) and premature birth (PB). However, pregnancy outcomes among adolescents with SLE have not been well explored.Objectives:To evaluate maternal and fetal outcomes in pregnant adolescents with SLE.Methods:We retrospectively studied all pregnant SLE adolescent patients, who attended to 3 Maternity Hospitals in Argentina in the last 5 years. Demographic, clinical, and laboratory data were collected. The presence of Antiphospholipid Syndrome (APS) and the Antiphospholipid antibodies (AA), and maternal and fetal outcome were evaluated. Adolescent pregnancy was defined it is happened between 10 and 19 years old. Lupus activity was evaluated by SELENA SLEDAI at the conception and each trimester of pregnancy and puerperium.Results:32 pregnancies in 21 patients were included. Mean age was 18 years old, 66% was mestizo ethnicity and mean disease duration of 2 years. Renal involvement was found in 19, Mucocutaneous in 21, and hematological in 14 patients. 4 patients had positive Anti-SSA/Ro antibodies, 1 Anti-SSB/La, 2 Lupus anticoagulant, 6 Ig G ACL, 3 Ig M ACL, and 8 patients fulfilled APS criteria. Activity disease was 0 SELENA SLEDAI in 1 ° trimester, 4 in 2°,3° trimester and puerperium. Maternal and fetal outcomes are shown in Table 1. Cesarean section was performed in 58%(n=18) of the patients, 6 had abortions and 1 fetal death.Table 1.Maternal outcomesDisease Flares13(41%) 7 renal (PE)/Hellp6 (19%)Gestational Diabetes1 (3%)Maternal outcomesSpontaneous Membrane Rupture1 (3%)Mortality0Fetal outcomeLive birth24 (75%)Gestational age (weeks)32 (32-38)Weight (grs)2805 (2100-3340)IUGR5 (16%)PB8 (25%)Conclusion:Maternal and fetal complications were high in adolescent pregnancy with SLE, including disease activity, PE and PB. A tight control of patients should be performed before and after conception. These patients should be managed by a multidisciplinary team, thus allowing an improvement of maternal and fetal prognosis.References:[1]Ling N, Lawson E, von Scheven E. Adverse Pregnancy outcome in adolescents and young women with systemic lupus erythematosus: a national estimate. Pediatric Rheumatology 2018, 16:26.[2]FraserA, Brockert J, Ward R: Association of young maternal age with adverse reproductive outcomes. N Engl J Med 1995, 223:1113-1117. 26.Disclosure of Interests:None declared

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Murray, Michelle L. "Uterine Activity Impacts Fetal and Neonatal Outcomes." International Journal of Childbirth 10, no. 1 (September 1, 2020): 2–9. http://dx.doi.org/10.1891/ijcbirth-d-19-00037.

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Uterine activity impacts fetal and neonatal outcomes. The value of analysis of contraction frequency and the duration of the resting interval were underappreciated until the last two decades. Misconceptions about electronic fetal monitoring and the cesarean section rate may be related to the lack of early research on the significant impact of abnormal uterine activity.

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Kallur, Sailaja Devi, and Nuzhat Aziz. "Do Fetal Monitoring Tests predict Adverse Perinatal Outcomes in Pregnant Women with Absent End Diastolic Flow? A Retrospective Study." International Journal of Infertility & Fetal Medicine 5, no. 1 (2014): 22–26. http://dx.doi.org/10.5005/jp-journals-10016-1076.

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Abstract Aim To determine the ability of fetal monitoring tests to predict adverse perinatal outcomes in absent end diastolic flow (AEDF) babies. Materials and methods A retrospective cohort study of pregnant women with AEDF during the period 2001 to 2009. Fetal monitoring tests of interest included amniotic fluid index (AFI), nonstress tests (NST), and Doppler flow studies. Adverse perinatal outcomes included perinatal/neonatal mortality, necrotizing enterocolitis, respiratory distress syndrome, and grades III/IV intraventricular hemorrhage. Sensitivity, specificity, likelihood ratios, adjusted odds ratios, area under the receiver operator characteristic curves (AUROC) and the 95% confidence intervals were determined. Study included 142 women with AEDF who delivered before 34 weeks. Indications for delivery included abnormal AFI in 6 (4.23%), worsening Doppler in 31 (21.83%), and abnormal NST in 48 (33.80%). An adverse fetal event was noted in 107 [75.35%, 95% confidence interial (CI) 68.18%, 82.53%]. Birth weight adjusted odds for an adverse perinatal outcome decreased (Odds ratio: 0.79, 95% CI: 0.56, 1.10, p = 0.16) with an increase in each week of gestation. Fetal monitoring tests did not have clinically meaningful positive/negative likelihood ratio or significant AUROC. Conclusion Current fetal monitoring tests are more useful to identify noncompromised fetuses than to identify fetal distress. Delaying delivery till 34 weeks might improve outcomes. How to cite this article Kallur SD, Aziz N. Do Fetal Monitoring Tests predict Adverse Perinatal Outcomes in Pregnant Women with Absent End Diastolic Flow? A Retrospective Study. Int J Infertil Fetal Med 2014;5(1):22-26.

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Agra, Isabela, Antonio Amorim Filho, Lawrence Lin, Sckarlet Biancolin, Rossana Francisco, and Maria Brizot. "Parameters Associated with Adverse Fetal Outcomes in Parvovirus B19 Congenital Infection." Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics 39, no. 11 (September 25, 2017): 596–601. http://dx.doi.org/10.1055/s-0037-1606859.

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Objective To investigate the clinical and sonographic parameters associated with adverse fetal outcomes in patients with congenital parvovirus B19 infection managed by intrauterine transfusion. Methods This was a single-center retrospective study conducted from January 2005 to December 2016 that assessed patients with singleton pregnancies with fetal parvovirus infection confirmed by a polymerase chain reaction of the amniotic fluid or fetal blood samples who underwent at least one intrauterine transfusion. The maternal characteristics, sonographic findings and parameters related to intrauterine transfusion were compared between the two groups (recovery/non-recovery), who were categorized based on fetal response after in-utero transfusions. Progression to fetal death or delivery without fetal recovery after the transfusions was considered non-recovery and categorized as an adverse outcome. Results The final analysis included ten singleton pregnancies: seven of which were categorized into the recovery group and three of which into the non-recovery group. The baseline characteristics were similar between the groups. All fetuses were hydropic at the time of diagnosis. No significant differences related to sonographic or intrauterine transfusion parameters were identified between the groups; however, the non-recovery group tended to have an increased number of sonographic markers and lower fetal hemoglobin and platelet levels before the transfusion. Conclusion We were unable to firmly establish the clinical or sonographic parameters associated with adverse fetal outcomes in patients with parvovirus infection managed with intrauterine transfusions; however, edema, placental thickening and oligohydramnios may indicate greater fetal compromise and, subsequently, adverse outcomes. However, further studies are necessary, mainly due to the small number of cases analyzed in the present study.

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Shankar, Priya, and Madhu J. "Study of maternal and fetal outcome in HIV positive women on HAART therapy in a tertiary hospital." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 2 (January 25, 2019): 717. http://dx.doi.org/10.18203/2320-1770.ijrcog20190311.

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Background: India has the third largest population of HIV. Moving from single dose nevirapine in labor to use of HAART treatment for all pregnant women and the outcome of the same was the subject of present study.Methods: Retrospective study of HIV positive pregnant women on HAART treatment admitted in labor room at Karnataka institute of medical sciences from June 2015 to December 2016. A retrospective analytical study of 93 women with HIV positive status on HAART therapy admitted in labor at KIMS was done by collecting data from case records. Baby follow up details were collected from ART center, KIMS.Results: Parameters studied were maternal and fetal outcomes. Maternal outcome in terms of mode of delivery, morbidity and mortality and fetal outcomes in terms of APGAR at birth, weight of the baby, NICU admission, incidence of meconium, still birth and intrauterine fetal demise, follow up of the babies at 6 weeks, 6 Months and 18 Months for seropositivity.Conclusions: HAART in pregnant women significantly improved the maternal and fetal outcomes.

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Poh, Yih Jia, Irene Yuen Lin Yii, Lim Hee Goh, Hui Hua Li, Liying Yang, Hak Koon Tan, Julian Thumboo, and Lay Kok Tan. "Maternal and Fetal Outcomes in Systemic Lupus Erythematosus Pregnancies." Annals of the Academy of Medicine, Singapore 49, no. 12 (December 31, 2020): 963–70. http://dx.doi.org/10.47102/annals-acadmedsg.2020373.

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Abstract Introduction: To describe the maternal and fetal outcomes in systemic lupus erythematosus (SLE) pregnancies followed-up in a single tertiary referral centre. Methods: We performed a retrospective cohort study of 75 SLE pregnancies who were followed up in Singapore General Hospital over a 16-year period from 2000 to 2016. Adverse fetal and maternal outcomes including preterm delivery, miscarriages, fetal growth restriction, congenital heart block, neonatal lupus, pre-eclampsia and SLE flares were obtained from the medical records. Results: The mean age at conception was 32 years old (SD 3.8). The mean SLE disease duration was 5.9 years (SD 5.2). The majority (88%) had quiescent SLE disease activity at baseline. Most pregnancies resulted in a live birth (74.7%). The mean gestational age at birth was 37.4 weeks (SD 3.4). Adverse fetal outcomes occurred in 53.3%. Preterm delivery (33.9%), miscarriages (20%) and fetal growth restriction (17.3%) were the most frequent adverse fetal outcomes. There was 1 neonatal death and SLE flares occurred in a third (33%). In the subgroup of SLE pregnancies with antiphospholipid syndrome, there were higher SLE flare rates (40%) and adverse fetal outcomes occurred in 8 pregnancies (80%). There were no predictive factors identified for all adverse fetal and maternal outcomes. In the subgroup analysis of preterm delivery, anti-Ro (SS-A) antibody positivity and hydroxychloroquine treatment were associated with a lower risk of preterm delivery. Conclusion: Although the majority had quiescent SLE disease activity at baseline, SLE pregnancies were associated with high rates of adverse fetal and maternal outcomes. Keywords: Antiphospholipid syndrome, anti-La (SS-B) antibody, anti-Ro (SS-A) antibody, lupus nephritis

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Towers, Craig V., Paul Terry, Breanne Rackley, Mark Hennessy, and Kevin Visconti. "Fetal Outcomes with Detoxification from Opioid Drugs during Pregnancy: A Systematic Review." American Journal of Perinatology 37, no. 07 (May 19, 2019): 679–88. http://dx.doi.org/10.1055/s-0039-1688908.

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Objective This study aimed to perform a systematic review of all studies reporting fetal outcomes following detoxification or tapering of opioid drugs during pregnancy. Study Design PubMed, Scopus, Medline, and Google Scholar were searched, and only manuscripts clearly reporting pregnancy/fetal outcomes involving tapering or detoxification from opioid drugs were included. Only pregnancies managed after 1980 were included (when antenatal fetal surveillance became more routine). Collected data included study design, location, years patients were managed, number of patients who were tapered or detoxified, method of tapering, and pregnancy outcome. Results A total of 14 publications met the criteria for review after evaluating more than 2,000 abstracts and 153 published manuscripts. In 1,097 pregnancies, based on mortality rate analyses and forest plots, no increased fetal risks due to tapering or detoxification from opioid drugs were identified. No increased risk of preterm delivery was found. Conclusion Pregnant women with opioid use disorder who are stable in a medication-assisted treatment program with behavioral health can be informed that tapering or full detoxification from opioid drugs does not increase the fetal risk of poor pregnancy outcome. Future research needs to answer the questions on maternal and long-term newborn consequences of tapering or detoxification versus long-term newborn consequences of continued chronic in utero opioid exposure.

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Bezircioğlu, İncim. "The effect of grandmultiparity on maternal, obstetric, fetal and neonatal outcomes." Perinatal Journal 21, no. 1 (April 1, 2013): 17–22. http://dx.doi.org/10.2399/prn.13.0211012.

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Spoor, Jochem K. H., Pravesh S. Gadjradj, Alex J. Eggink, Philip L. J. DeKoninck, Bart Lutters, Jeroen R. Scheepe, Jetty van Meeteren, Peter C. J. de Laat, Marie Lise van Veelen, and Tjeerd H. R. de Jong. "Contemporary management and outcome of myelomeningocele: the Rotterdam experience." Neurosurgical Focus 47, no. 4 (October 2019): E3. http://dx.doi.org/10.3171/2019.7.focus19447.

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OBJECTIVEMyelomeningocele (MMC) is the most common form of spina bifida, with a lifelong impact on the quality of life for infants born with this condition. In recent decades, fetal surgery has evolved from an experimental therapy to standard of care for many centers in the world. In this study, the authors aimed to provide an overview of the current management and outcomes for infants with MMC managed at their institution. This then provides a center-specific historical cohort for comparison with future antenatal-treated MMC cases.METHODSThis is a retrospective, single-institution cohort study including all consecutive MMC cases between January 1, 2000, and June 1, 2018, at Erasmus MC. Outcome data included closure of the defect (location, timing, and surgical parameters), hydrocephalus management, Chiari malformation type II (CMTII) management, incidence of spinal cord tethering and outcome, motor outcomes, and continence.RESULTSA total of 93 patients were included with predominantly lumbosacral lesions. Two patients died during follow-up. Hydrocephalus was present in 84%, with a 71% ventriculoperitoneal shunt reoperation rate. Surgery was performed in 12% for a tethered spinal cord at a mean age of 8 years. Decompression surgery was performed in 3 patients for CMTII. Special education in 63% was significantly associated with hydrocephalus (p < 0.015). Nineteen percent of patients were able to walk independently, and 47% were nonambulators. Social continence for urine was obtained in 75% of patients, 4% had fecal incontinence.CONCLUSIONSThis study provides an overview of current MMC outcomes at the authors’ center and will serve as a historical cohort for comparison with future fetal surgery cases operated on at the center in the coming years. Apart from a relatively low surgical untethering rate, the authors’ outcome data are comparable to those in the literature. Hydrocephalus is highly prevalent in postnatally treated MMC patients; in this study as in much of the literature, hydrocephalus is correlated with a low cognitive function. Fetal surgery for MMC halves the need for shunt treatment in a select group of MMC pregnancies, constituting a major indication for us to undergo the transition to a fetal surgery center. The fetal benefits of open antenatal surgery for MMC are well established, yet long-term data on especially tethered spinal cord are eagerly awaited.

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Pokhanna, Joysee, Urvi Gupta, Madhuri Alwani, and Shruti Pathak Tiwari. "Prevalence of thyroid dysfunction and impact on maternal and fetal outcome in Central Indian pregnant women." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 10 (September 23, 2017): 4666. http://dx.doi.org/10.18203/2320-1770.ijrcog20174461.

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Introduction: Thyroid dysfunctions have become common endocrine problems in pregnant women. It is now well established that not only overt, but subclinical thyroid dysfunction also has adverse effects on maternal and fetal outcome. There are very few data from India about the prevalence of thyroid dysfunction in pregnancy. In this study, we determined the prevalence of thyroid dysfunction in pregnancy and its impact on obstetrical outcome in Central Indian Indore Pregnant Women.Methods: Total 300 pregnant women between the 13 and 26 weeks of gestation were recruited for this study who is residing in Indore. In all patients routine obstetrical investigations, TSH tests were done. Anti-TPO antibody tests and Free T4 were done in patients with deranged TSH. The obstetrical and perinatal outcomes were recorded. Almost all the patients were followed up to delivery.Results: The prevalence of hypothyroidism and hyperthyroidism was 13 and 4%, respectively. Adverse maternal effects in overt hypothyroidism included preeclampsia (22.2 versus 11.6%) and placental abruption (22.2 versus 2.0%). Subclinical hypothyroidism was associated with preeclampsia (30.0 versus 11.6%) as compared to the euthyroid patients. Adverse fetal outcomes in overt hypothyroidism included spontaneous abortion (22.2 versus 6.6%), preterm birth (44.4 versus 30.0%), low birth weight (66.6 versus 30.0%), intrauterine growth retardation (33.3 versus 10.0%), and fetal death (22.2 versus 0%) as compared to the euthyroid women. Adverse fetal outcomes in subclinical hypothyroidism included spontaneous abortion (2.0 versus 6.6%), preterm delivery (5.2 versus 30.0%), low birth weight (11.2 versus 30.0%), and intrauterine growth retardation (4.4 versus 10 %) as compared to the euthyroid women.Conclusions: The prevalence of thyroid disorders was high in our study with associated adverse maternal and fetal outcomes. Routine screening of thyroid dysfunction is recommended to prevent adverse fetal and maternal outcome.

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Park, Ji-Eun, Hyen-Chul Jo, Seon-Mi Lee, Jong-Chul Baek, In-Ae Cho, and Soon-Ae Lee. "Mild Fetal Tricuspid Regurgitation in the First Trimester as a Predictor of Perinatal Outcomes." Medicina 57, no. 6 (June 19, 2021): 637. http://dx.doi.org/10.3390/medicina57060637.

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Background and Objectives: This study aimed to investigate whether mild fetal tricuspid regurgitation (TR) at 11+ 0 to 13+ 6 weeks of gestation affects perinatal outcomes. Since fetal right ventricular load is associated with placental resistance, we hypothesized that fetal mild TR would be associated with perinatal outcomes as a consequence of abnormal placentation. Materials and Methods: We retrospectively evaluated 435 women with first-trimester scan data. Blood flow across the tricuspid valve was examined in singleton pregnancies between 11+ 0 and 13+ 6 weeks of gestation. Women were categorized according to the presence or absence of fetal mild TR, and the maternal and pregnancy characteristics and perinatal outcomes were compared. Multiple linear and logistic regression analyses were conducted to identify independent predictors of perinatal outcome. Results: In the group with mild TR, there were more cases of borderline amniotic fluid index, including oligohydramnios (p = 0.031), and gestational age- and sex-specific birth weights were lower (p = 0.012). There were no significant differences in other perinatal outcomes, including preeclampsia, gestational hypertension and small for gestational age. Gestational diabetes (adjusted odds ratio (OR) 0.514, 95% confidence interval (CI) 0.312–0.947) and fetal mild TR (adjusted OR 1.602, 95% CI 1.080–2.384) were identified as factors associated with below borderline amniotic fluid index before birth. The factors that affected gestational age and sex-specific birth weight were also gestational diabetes (adjusted beta coefficient 9.673, p = 0.008) and the presence of fetal mild TR (adjusted beta coefficient −6.593, p = 0.007). Conclusions: Mild fetal TR observed in the first trimester is negatively associated with fetal growth and the amniotic fluid index at term but not with other adverse pregnancy or perinatal outcomes due to abnormal placentation.

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Journal articles on the topic 'Fetal outcomes'

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