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1
Ptok, Andrzej. "Mechanizmy stabilizujące fazę nadprzewodzącą typu Fulde-Ferrell-Lakin-Ovchinnikov." Doctoral thesis, Katowice : Uniwersytet Śląski, 2012. http://hdl.handle.net/20.500.12128/5337.
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Prezentowana rozprawa poświęcona jest czynnikom stabilizującym fazę nadprzewodzącą
typu Fulde-Ferrella-Larkina-Ovchinnikova, czyli fazę, w której pary Coopera posiadają
niezerowy całkowity pęd. We wstępie (rozdział 1, omówione zostały główne cechy
fazy FFLO oraz eksperymentalne przesłanki istnienia tej fazy. Ze względu na restrykcyjne
wymogi, jakie muszą spełniać materiały, w których można obserwować fazę FFLO, kluczowe
było określenie czynników wpływających na stabilność tej fazy. W rozprawie tej
przedstawione zostały następujące czynniki:
• wpływ przeskoku par - w rozdziale 2
• wpływ niejednorodności układu (domieszek) - w rozdziale 3
• wpływ fal gęstości spinów - w rozdziale 4
W rozdziale 2 pokazaliśmy, że przeskok par elektronów wpływa na efektywny potencjał
parujący. Występowanie przeskoku par elektronowych obniża wartości pola magnetycznego
przy którym pojawia się FFLO. Dodatkowo pokazaliśmy możliwość istnienia dwóch
różnych faz FFLO - gdy całka przeskoku par J jest mała, otrzymujemy FFLO z małym
całkowitym pędem, natomiast dla względnie dużych J otrzymujemy FFLO z pędem w pobliżu wierzchołków FBZ.
W rozdziale 3 rozważaliśmy wpływ niejednorodności układu (domieszek) na stabilność
fazy FFLO. W szczególności chcieliśmy przetestować powszechnie akceptowany pogląd,
że faza FFLO występuje jedynie w układach bardzo czystych i nawet niewielka liczba
domnieszek prowadzi do jej zniszczenia. Okazało się, że taki wniosek był konsekwencją
obliczeń prowadzonych tylko z jedną wybraną wartością pędu par Coopera. Tymczasem
domieszki prowadzą do dodatkowej lokalnej modulacji nadprzewodzącego parametru porządku.
Transformacja Fouriera takiego rozkładu A (R t) daje wiele zbliżonych wkładów
A (q). Oznacza to, że w układach niejednorodnych może występować nadprzewodnictwo
z niezerowym pędem par, jednak należy uwzględnić wiele możliwych wartości pędów. Przestrzenny
rozkład parametru porządku zgodny z postacią LO powinien zostać zastąpiony
bardziej ogólną, którą w rozprawie oznaczałem jako FFLO. Pokazaliśmy dodatkowo, że
nieporządek diagonalny powoduje zmniejszenie wartości parametru porządku, natomiast
nieporządek pozadiagonalny może powodować jego wzrost.
W chwili obecnej najsilniejsze przesłanki eksperymentalne potwierdzające obecność fazy
FFLO dotyczą nadprzewodnictwa ciężkofermionowego CeColn5. Jeśli nadprzewodnictwo
FFLO faktycznie występuje w tym układzie, to musi ono współistnieć z SDW, którego
obecność została jednoznacznie potwierdzona w eksperymentach z rozpraszaniem neutronów.
W rozdział 4 pokazaliśmy, że obecność SDW nie tylko nie wyklucza obecności
FFLO, lecz przeciwnie jest dodatkowym argumentem przemawiającym za obecnością tej
wyjątkowej fazy nadprzewodzącej.
2
Mora, Christophe. "Gaz de bosons et de fermions condensés : phases de Fulde-Ferrell-Larkin-Ovchinnikov et quasicondensats." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2004. http://tel.archives-ouvertes.fr/tel-00005472.
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La première partie de cette thèse concerne les phases inhomogènesFFLO. Celles-ci peuvent apparaître dans les supraconducteurs
ou les gaz d'atomes froids fermioniques en présence d'une différence
homogène de potentiels chimiques entre les deux états de spin.
Nous regardons la compétition
entre les différentes phases FFLO près de la transition.
A 2D, nous utilisons une approche de type Ginzburg-Landau
pour prédire une cascade de transitions entre des phases inhomogènes
de plus en plus complexes.
A 3D ou la transition FFLO est du premier ordre,
nous présentons une méthode numérique
de résolution des équations quasiclassiques d'Eilenberger
basée sur un développement de Fourier.
Nous déterminons ainsi les phases inhomogènes de plus basse énergie.
Dans la seconde partie, nous étendons la théorie perturbative
de Bogoliubov aux quasicondensats dans une représentation densité-phase.
Nous obtenons des prédictions pour différentes observables.
3
Burns, William James. "We Must Grow Our Own Artists: Mary-Russell Ferrell Colton, Northern Arizona's Early Art Educator." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/eps_diss/54.
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What were Mary-Russell Ferrell Colton’s contributions to the progressive education movement and the Indian arts and crafts movement in the Southwestern United States at a time when the region was still very remote? Artist, author, amateur ethnographer, educator, and curator; these were but a few of the talents of Mary-Russell Ferrell Colton, co-founder of the Museum of Northern Arizona and early art advocate on the Colorado Plateau. This study investigates how Colton contributed to the progressive education movement and the Indian arts and crafts movement through the work that she did at the museum. There, she labored to increase public awareness of the importance of art education and to revive Native American arts on the Colorado Plateau. Using an extensive collection of archival material in the Colton Collection at the Museum of Northern Arizona, as well as oral history interviews, this historical study provides a nuanced analysis of Colton’s life as an educator. Colton’s influence is not well known today, but her professional contributions merit recognition, giving her a place in the history of American education. This study reveals how Colton’s efforts fit within the context of the work of her contemporaries in Santa Fe and Taos, and within the progressive education movement, from the then relatively remote outpost of Flagstaff. Much can be learned from Colton’s work that is relevant to the field of education today. Her ideals and writings about art education will resonate with opponents of No Child Left Behind. Colton’s work as one of northern Arizona’s earliest art educators contributed to a better understanding of the culture of the various peoples of the Colorado Plateau and to the preservation of Navajo and Hopi traditions through education. Colton made notable contributions to the Indian arts and crafts movement, museum education, and the progressive education movement. A woman of firm convictions and ideals, Colton was strong-willed, and complex, a multi-faceted person with a broad range of interests which she pursued with passion and commitment. This study crosses the boundaries of several disciplines, including educational history, museum studies, women’s studies, educational biography, Native American studies, and art education.
4
Whitley, William George. "Charge density waves and superconductivity in U6Fe." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/22031.
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U6Fe has the highest superconducting transition temperature TSC ~ 4 K out of all of the U-based compounds. Unusually, the Pauli limit (1:84TSC = 7:36 T) is less than the observed critical field for both the a and c axes in this tetragonal material. Neither Pauli or usual BCS orbital limit is apparently respected. In order to explain why superconductivity exceeds the Pauli limit, it must be considered that either the superconducting state is unaffected by paramagnetic effects, or there is a large amount of spin-orbit scattering. Superconductivity is in the dirty limit for typical samples of U6Fe, which means that the latter cannot be precluded. Another unusual property of the superconducting state of U6Fe is that TSC has a positive dependence on the applied pressure P, for P < 4 kbar. This combined with other subtle signals in various measurements have led to the suggestion that a Charge Density Wave (CDW) state may exist in U6Fe below 110 K. The CDW state is typically favoured by materials with low-dimensional structural features such as chains of atoms. Such materials, if superconductors, are also candidates to exhibit the sought-after Fulde-Ferrell-Larkin-Ovchinnikov (FFLO) state, an unusual state in which the superconducting order parameter is modulated in real space. The FFLO is expected to be suppressed except in clean, Pauli limited materials. Therefore if U6Fe can be produced at high enough quality to bring the superconducting state into the clean limit, it would be a potential candidate for an FFLO state. Part of this project discusses apparatus and techniques applied with the goal of producing such quality samples of U6Fe. We have succeeded in the application of the Solid State Electrotransport (SSE) method to purifying samples, and have been able to replicate the highest Residual Resistivity Ratios (RRRs) achieved (~9, compared to 4 for typical samples), but for single crystals instead of the polycrystals produced in the past. In parallel with the progress made towards higher quality samples of U6Fe, a new X-ray scanner has been developed for grain mapping of samples. This has found application in the course of our synthesis studies. The best quality samples have been studied by X-ray diffraction on the XMaS beamline at the ESRF in Grenoble, France. Below TCDW ~ 10 K, satellites at (δH; δK; 0) = (±0:11;±0:11; 0) were observed that confirm a CDW state, albeit at much lower temperatures than anticipated. By examination of systematic satellite absences we have determined that the displacement vector → u is perpendicular to the modulation direction in k-space. Additionally it has been found that the symmetry of the lattice below TCDW is reduced from that of the room temperature I4=mcm structure. The appearance of additional Bragg peaks below ~110 K during these experiments were later cast into doubt by multiple scattering. We have, however, detected a signal in the form of a jump at ~110 K in specific heat measurements of our samples. These measurements also show a kink near to TCDW. We have additionally extended the investigation of the effect of pressure on the superconducting state. The maximum of TSC is confirmed in our samples, and the subsequent suppression of TSC and Hc2 is investigated up to 8 GPa. We have analysed our Hc2(T) curves at different pressures under a simple two-band model that fits the observed trends well and suggest that at the highest pressures U6Fe is approaching even more unusually enhanced Hc2 values.
5
Barkman, Mats. "Investigation of Order Parameter Structures of the Fulde-Ferrell-Larkin-Ovchinnikov State in Superconductors Using the Finite Element Method." Thesis, KTH, Fysik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-233563.
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Berridge, Andrew McConnell. "Itinerant metamagnetism and magnetic inhomogeneity : a magnetic analogue of the superconducting Fulde-Ferrell-Larkin-Ovchinnikov phase in Sr₃Ru₂O₇." Thesis, University of St Andrews, 2009. http://hdl.handle.net/10023/821.
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The formation of magnetic order in solids is a complex and subtle issue. There are a wide range of different types of magnetisation, all of which may be favoured under different circumstances. In this thesis we consider a novel combination of ideas where the formation of spatially modulated magnetisation is linked to a metamagnetic transition. In this we are inspired by a general principle of modulated phases intervening as intermediate states in phase transitions. In particular we draw analogies with the Fulde-Ferrell-Larkin-Ovchinnikov state of spatially modulated superconductivity. We study a mean-field theory for itinerant magnetism where the crystal lattice drives the formation of a rich phase diagram. A peak in the electronic density of states due to a van Hove singularity creates ferromagnetism and a metamagnetic transition. Furthermore we find that a modulated magnetic phase - a spin-spiral, becomes favoured along the metamagnetic transition line. The appearance of this phase causes the metamagnetic transition to bifurcate to enclose the modulated region. The topology of this reconstructed phase diagram shows remarkable similarity to that observed in experiments on Sr₃Ru₂O₇. This material shows a metamagnetic transition which can be tuned by field angle towards zero temperature. Before this point is reached a new phase with high and anisotropic resistivity appears. We believe that this anomalous phase can be explained by the formation of a phase of modulated magnetisation caused by a peak in the electronic density of states. This mechanism may also apply in a range of other materials as it is driven by rather generic features of the bandstructure.
7
Kehrle, Jan-Michael [Verfasser], and Siegfried R. [Akademischer Betreuer] Horn. "The Fulde-Ferrell Larkin-Ovchinnikov Like State in Bilayers and Trilayers of Superconducting and Ferromagnetic Thin Films / Jan-Michael Kehrle. Betreuer: Siegfried Horn." Augsburg : Universität Augsburg, 2012. http://d-nb.info/107770108X/34.
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Newbold, Haylie Goldene. "Infra-red vision in ferrets (Mustela furo)." The University of Waikato, 2007. http://hdl.handle.net/10289/2357.
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Ferrets are labelled Unwanted Organisms under the Biosecurity Act (1993) due to their predation on New Zealand's native protected species and their status as potential vectors of Bovine Tuberculosis. There was suspicion that ferrets could detect the infrared light-emitting equipment used to monitor predator and prey behaviour. A two-alternative forced-choice operant procedure was used to test whether five pigmented male ferrets could detect infrared (870 and 920 nm) light. First, the ferrets were taught to press a lever under a lit visible (white) light emitting diode (LED) for food rewards. After up to 101 40-minute sessions, each ferret could lever press under the lit-light at or above the pass criteria of 75% responses over four consecutive (or five out of six) sessions. The same ferrets were then tested for stimulus generalisation over different stimulus properties by changing the wavelength/colour and intensity of the lit-light. The overall mean accuracy of each ferret's response to each coloured light varied between 92% and 84%. When a red light was systematically dimmed to halve the intensity nine times, all five ferrets still met the set pass criteria with overall accuracies of between 88% and 78%. This indicated that changing the properties of the light stimuli would not disrupt the ferrets' abilities to perform the learned task. This test was a necessary prerequisite before changing the light stimuli to potentially invisible wavelengths in the infrared spectrum. The light stimulus was changed to a single infrared (870) nm LED. Two of five ferrets showed strong evidence (response accuracies of 77% 4 and 72% 2) and one ferret showed weak evidence (60% 3) that they could see the light at this wavelength. Extraneous cues such as ultrasound emitted at the onset of a stimulus light or a predictable schedule of reinforcement were eliminated as potential response cues. These tests helped to prove that the ferrets were using only the light stimulus to discriminate which stimulus was lit. It may be possible that at least some feral ferrets can detect the light produced from infrared monitoring equipment that emits light wavelengths at or below 870 nm. This has significant implications for conservation because infrared equipment is used by conservation agencies in New Zealand and overseas to monitor predator and prey behaviour in the wild. If the infrared lighting is detected by the subject being observed, then it may potentially influence the behaviour of the animal, or attract a predator towards threatened native species.
9
Pease, García Yrigoyen Franklin. "Onorio Ferrero (1908-1989)." Pontificia Universidad Católica del Perú, 2014. http://repositorio.pucp.edu.pe/index/handle/123456789/122105.
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Siu, Selina. "Computer Aided Ferret Design." Thesis, University of Waterloo, 2003. http://hdl.handle.net/10012/1184.
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Ferrets are amusing, flexible creatures that have been under represented in computer models. Because their bodies can assume almost any curved shape, splines are the natural tool for modelling ferrets. Surface pasting is a hierarchical method of modelling with spline surfaces, where features are added onto a base surface. Existing surface pasting techniques are limited to modelling rectilinear shapes. Using the task of modelling a ferret as a driving force, I propose a method of pasting cylinders in world space; I looked at methods for reducing distortion of pasted features; and I created a method for pasting trimmed features to allow for features that do not have the rectilinear shape of standard pasting. With my methods, modelling ferrets with surface pasting is easier, and the resulting models are closer to a real ferret.
11
Hamayon, Stéphane, and Axel de Ferran. "Les marchés des métaux non ferreux." Paris 10, 1989. http://www.theses.fr/1989PA100026.
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L'objectif de la première partie est d'établir une typologie des marches des métaux non-ferreux au moyen d'analyses statistiques multidimensionnelles. Cet objectif a nécessité la construction et la sélection d'indicateurs complexes, caractéristiques des marchés des produits étudiés. Les résultats des analyses statistiques ont permis d'établir des classifications pertinentes. La deuxième partie est plus spécialement consacrée a l'analyse de l'évolution des prix des métaux non-ferreux et aux différentes méthodologies utilisées pour modéliser les marches des produits de base. Apres une présentation historique générale des modèles, le marché de l'étain fait l'objet d'une étude économétrique destinée a analyser les causes de son disfonctionnement, permettant ainsi de juger l'efficacité des politiques de stabilisation utilisées par la CnucedObjective of first part is to set up a classification of non-ferrous markets through multivariale statistical analysis. It has induced construction and selection of complex indicators to caracterize the markets. Results of statistical analysis allowed us to make relevant classifications. Second part is mainly devoted to analyse evolution of prices of non-ferrous metals and to study the different kinds of modelizations for commodity markets. After a general presentation of the models, we focalized on tin market to analyse the reasons of its problems and to be able to study the efficiency of Cnuced commodity markets stabilization policies
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Chazot, Matthieu. "Verres chalcogénures dopés aux ions ferreux." Master's thesis, Université Laval, 2015. http://hdl.handle.net/20.500.11794/26467.
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Tableau d'honneur de la Faculté des études supérieures et postdorales, 2015-2016Dans le domaine de la photonique, le bande spectrale s’étalant de 3 à 5 μm fait office de la prochaine frontière à franchir dans le domaine des lasers. Les champs d’applications sont nombreux; on peut citer entre autres la spectroscopie moléculaire, la chirurgie, les capteurs atmosphériques ou encore les systèmes de contre-mesure dans le domaine militaire. Ce projet porte sur le développement de verres chalcogénures de haute pureté, dopés aux ions de métaux de transition et en particulier les ions ferreux, afin de les utiliser pour remplacer les cristaux de ZnSe comme cavité résonante et répondre ainsi à la forte demande de sources lasers compactes opérant entre 3 et 5 microns. La forte non-linéarité de ces verres associée à leur transparence dans l’infrarouge en font de bons candidats pour des applications passives et actives dans l’infrarouge. Dans ce travail on met l’emphase sur la synthèse et la caractérisation des verres chalcogénures dopés aux ions ferreux. Le choix de la matrice vitreuse et de la quantité des ions Fe2+ sont les paramètres fondamentaux à contrôler pour l’émission entre 3 et 5 μm. Les matrices Ge28Sb12Se60 et Ge33As12Se55 ont été sélectionnées au cours de ce projet pour leur bonne capacité à accepter de grandes concentrations d’ions ferreux sans cristalliser. Une analyse détaillée de leurs spectres d’absorption en fonction de la concentration en ions Fe2+ a été effectuée dans le but de déterminer la concentration optimale en dopant à utiliser pour avoir une fluorescence entre 3 et 5 microns. Par ailleurs des compositions vitreuses chalcohalogénures ont également été explorées lors de cette étude afin d’améliorer les paramètres optiques des verres. Des mesures de fluorescences des échantillons ont finalement été effectuées et sont présentées dans ce travail.
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Fisher, John T. "Ferret CFTR processing and function." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/3453.
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The most common cystic fibrosis transmembrane conductance regulator (CFTR) gene mutation is δF508 and this causes cystic fibrosis (CF). Animal models that recapitulate the human disease phenotype are critical to understanding pathophysiologic mechanisms in CF and developing therapies. New CF models in the pig and ferret have been generated that develop lung, pancreatic, liver, and intestinal pathologies that reflect disease in CF patients. Species-specific biology in the processing of CFTR has demonstrated that pig and mouse δF508-CFTR proteins are more effectively processed to the apical membrane of airway epithelia than human δF508-CFTR. The processing behavior of ferret wild-type (WT) and δF508-CFTR proteins remain unknown and such information is important to predicting the utility of a δF508-CFTR ferret. To this end, we sought to compare processing, membrane stability, and function of human and ferret WT- and δF508-CFTR proteins in a heterologous expression system using HT1080, HEK293T, BHK21, and Cos7 cells, as well as human and ferret CF polarized airway epithelia. Analysis of the protein processing and stability by metabolic pulse-chase and surface On-Cell Western blots revealed that WT-fCFTR half-life and membrane stability were increased relative to WT-hCFTR. Furthermore, in BHK21, Cos7, and CuFi cells, human and ferret δF508-CFTR processing was negligible, while low levels of processing of δF508-fCFTR could be seen in HT1080 and HEK293T cells. Only the WT-fCFTR, but not δF508-fCFTR, produced functional cAMP-inducible chloride currents in both CF human and ferret airway epithelia. Further elucidation of the mechanism responsible for elevated fCFTR protein stability may lead to new therapeutic approaches to augment CFTR function. These findings also suggest that generation of a ferret CFTRδF508/δF508 animal model may be useful.
Furthermore, in the CFTR and CFTR+/+ ferret model we have characterized abnormalities in the bioelectric properties of the trachea, stomach, intestine and gallbladder of newborn CF ferrets. Short circuit current (ISC) analysis of CF and WT tracheas revealed the following similarities and differences: 1) amiloride sensitive sodium currents were similar between genotypes, 2) responses to 4,4'-diisothiocyano-2,2'-stilbene disulphonic acid (DIDS) were ~4-fold greater in CF animals, suggesting elevated baseline chloride transport through non-CFTR channels, and 3) as expected, there was a lack of IBMX/forskolin-stimulated and GlyH-101-inhibited currents in CF animals due to the lack of CFTR. CFTR mRNA and protein was present throughout all levels of the WT ferret and IBMX/forskolin-inducible ISC was only observed in WT animals. Interestingly, IBMX/forskolin-inducible intestinal ISC in WT animals was not inhibited by the CFTR inhibitor GlyH-101 or bumetanide. The luminal pH of the CF ferret stomach was significantly decreased relative to the controls, while both genotypes maintained near neutral pH along the length of the intestine. The WT stomach and gallbladder exhibited significantly enhanced IBMX/forskolin ISC responses and inhibition by GlyH-101 relative to CF samples. These findings demonstrate that multiple organs affected by disease in the CF ferret have bioelectric abnormalities consistent with the lack of cAMP-mediated chloride transport.
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Geffroy, Pierre-Marie. "Mise en forme d'alliages ferreux et non ferreux par un procédé de fonderie assisté par un champ magnétique." Bordeaux 1, 2005. http://www.theses.fr/2005BOR12979.
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L'étude concerne un procédé original de fonderie qui combine les avantages du moulage coquille et du procédé en moule plein, ou plus connu sous le nom du procédé "Lost Foam". Ce procédé, appelé moulage magnétique, repose sur l'utilisation d'un modèle facilement pyrolysable, et d'un moule malléable et recyclable, la grenaille. Au cours de la coulée, le métal liquide vient brûler le modèle, et la consolidation du moule en grenaille est alors assurée par l'application d'un champ magnétique externe. L'objet de cette étude est d'améliorer la qualité métallurgique et les tolérances dimensionnelles des pièces moulées, et de définir l'ensemble des avantages et inconvénients liés à cette nouvelle technologie. Ainsi, cette étude a permis d'établir des lois de comportement mécanique du moule en grenaille et les lois reliant la cohésion du moule en grenaille et le champ magnétique appliqué externe. Ce travail monte également que, via les propriétés thermiques du moule, les alliages ferreux et non ferreux coulés présentent un affinement de leur microstructure qui conduit à des propriétés mécaniques supérieures à celles obtenues par un moulage en sable traditionnel, mais inférieures à celles obtenues par un moulage en coquille.
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Vásquez, Rossi María Inés. "Desde dentro. Entrevista con Carlos Ferrero Costa." IUS ET VERITAS, 2016. http://repositorio.pucp.edu.pe/index/handle/123456789/123182.
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Carlos Perrero Costa, congresista de Cambio 90-Nueva Mayoría, nos ofrece una visión crítica de los últimos acontecimientos relacionados con la institucionalidad del país y el conflicto con el Ecuador, dando muestra de autonomía política y conciencia democrática.
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Guzmán, Zorrilla Emanuel Jesús. "Modelamiento de corrientes superficiales inducidas por viento y marea en la bahía Ferrol - Chimbote." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2006. https://hdl.handle.net/20.500.12672/2535.
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Se realizaron simulaciones numéricas del patrón de corrientes superficiales forzados por viento y marea en la bahía Ferrol – Chimbote, con el objetivo determinar la influencia de dichas forzantes, dando así un diagnóstico del patrón de corrientes que servirá como contribución a la evaluación de recambio de aguas y su influencia en el proceso de contaminación en la bahía.
El modelo numérico empleado fue el Princeton Ocean Model, más conocido por la comunidad científica internacional como modelo POM.
Las simulaciones realizadas fueron de carácter bidimensional, debido a que la bahía presenta características de aguas poco profundas, con una profundidad máxima de 30 metros dentro de la bahía.
Se emplearon datos de batimetría y del perfil costero con alta resolución de las cartas de navegación de la Dirección de Hidrografía y Navegación (DHN), complementados con datos globales disponibles de bases de datos digitales (ETOPO2) e información de satélites.
Para las simulaciones con viento, se empleó la climatología elaborada por el Internacional Research Institute (IRI). Para simular la corriente de marea, se empleó como forzante los principales constituyentes armónicos de marea obtenidos del modelo global TOPEX6.0, los cuales fueron comparados con las predicciones de marea publicadas en Internet por la DHN.
Los resultados obtenidos, nos muestran la influencia del viento y la marea en la generación de corrientes, concluyendo que debido a la configuración morfológica de la bahía, la circulación que se presenta es muy lenta y que la marea ejerce mayor influencia en la circulación dentro de la bahía Ferrol, mientras que la influencia del viento es notoria fuera de la bahía.Tesis
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Carvalho, Sara Monaliza Costa. "Teste de tetrazólio em sementes de jucá (Libidibia ferrea (Mart. ex Tul.) L.P. Queiroz var. ferrea)." Universidade Federal Rural do Semi-Árido, 2016. http://bdtd.ufersa.edu.br:80/tede/handle/tede/574.
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Currently, the most widely used test for assessing the seed physiological quality is the germination. However, this presents some obstacles, the largest one, is a long time to obtain results, especially for forest species. The tetrazolium test provides fast results, and this has proved to be a promising alternative for the determination of viability of this kind of seed. However, the success of the test depends on the development of an appropriate methodology for each species. Thus, this research aimed to evaluate procedures for the pre-wetting, preparation and staining jucá seeds to tetrazolium test. The experiments have been divided into two steps. As in the first trial were tested pre-wetting conditions and seed preparation, the second was dedicated to the dyeing stage, in which three concentrations of tetrazolium solution were tested (0.05, 0.075 and 0.1%) and three periods (1, 3 and 6 hours) at the temperatures of 35 to 40 ° C. The seeds were sorted into viable or non-viable according to the colorations obtained. At the same time, the germination test was conducted to compare the results with the feasibility estimates by the tetrazolium test. It was found that the mentioned test is efficient to evaluate the feasibility of jucá seeds and to implement it is recommended the scarification of the seeds with sandpaper followed by soaked paper towel for 42 hours at 25 ° C and removal of the seed coat, with subsequent immersion of the seeds into the tetrazolium solution at 0.05% for 3 hours at 35 or 40 ° C
Atualmente o teste mais utilizado para a avaliação da qualidade fisiológica de sementes é o de germinação. No entanto, este apresenta alguns entraves, sendo o maior deles o longo tempo para obtenção de resultados, principalmente para as espécies florestais. O teste de tetrazólio proporciona resultados rápidos e por isso tem se mostrado uma alternativa promissora na determinação da viabilidade de sementes dessas espécies. Todavia, o sucesso do teste depende do desenvolvimento de metodologia adequada para cada espécie. Assim, essa pesquisa teve como objetivo avaliar procedimentos destinados ao pré-umedecimento, preparo e coloração de sementes de jucá para o teste de tetrazólio. Os experimentos foram divididos em duas etapas. Enquanto no primeiro ensaio foram testadas condições de pré-umedecimento e preparo das sementes, o segundo foi dedicado à fase de coloração, onde foram testadas: três concentrações da solução de tetrazólio (0,05; 0,075 e 0,1%) e três períodos (1, 3 e 6 horas), nas temperaturas de 35 e 40 °C. As sementes foram classificadas em viáveis ou inviáveis de acordo com as colorações obtidas. Paralelamente, foi conduzido o teste de germinação para comparação dos resultados com as estimativas de viabilidade do teste de tetrazólio. Constatou-se que o teste de tetrazólio é eficiente para avaliar a viabilidade de sementes de jucá e para a sua execução recomenda-se a escarificação das sementes com lixa seguida de embebição em papel toalha por 42 horas a 25 °C e retirada do tegumento, com posterior imersão das sementes em solução de tetrazólio a 0,05% por 3 horas, a 35 ou 40 °C
2016-12-05
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Joos, Olivier. "Compréhension des mécanismes d'endommagement couplés des cylindres de travail pour le laminage à chaud des alliages ferreux et non ferreux." Paris, ENMP, 2009. http://www.theses.fr/2009ENMP1655.
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L'arrêt d'un laminoir à chaud pour remplacer un cylindre de travail est coûteux. Le remplacement d'un cylindre intervient dès que la qualité de surface de la bande n'est plus satisfaisante. Or la qualité de surface de la bande est le miroir de celle du cylindre. Du fait des nombreuses sollicitations de service couplées (oxydation, abrasion/adhésion, fatigue thermique), la surface des cylindres est progressivement endommagée. Suivant la position du cylindre dans le train, l'amplitude relative des sollicitations varie. L'augmentation de la productivité du laminoir passe par l'augmentation de la durée de vie d'un cylindre, c'est-à-dire l'augmentation de la résistance à l'oxydation, à l'abrasion/adhésion et/ou à la fissuration thermique de la nuance. L'objectif de ce travail consiste à corréler la microstructure de 4 nuances d'étude à la résistance aux différentes sollicitations, qui, à l'échelle du laboratoire, ont été découplées. Après avoir identifié les différences microstructurales des nuances à travers plusieurs paramètres (structure de solidification ; nature, composition chimique, morphologie et distribution des carbures primaires et secondaires ; structure et composition chimique de la matrice,…), nous montrons dans un premier temps comment ces paramètres influencent les mécanismes d'oxydation des nuances. Dans un second temps, nous analysons l'impact de ces paramètres sur les mécanismes d'endommagement lors de sollicitations couplées : l'abrasion et l'oxydation d'une part, la fatigue thermique et l'oxydation d'autre part. L'optimisation de la microstructure d'une nuance se fera en pondérant la présence de ces différents paramètresThe interruption of a hot strip mill in order to replace a work roll is very expensive. This replacement is mainly motivated by strip surface quality degradation. The strip surface quality is the mirror of the roll one. Because of numerous coupled solicitations during service (oxidation, abrasion/adhesion, thermal fatigue), the roll surface is continuously damaged. The relative amplitude of each solicitation depend of the roll position in the mill. The productivity improvement is also linked to the roll life increase, in others words is linked to the enhancement of roll resistance to oxidation, abrasion/adhesion and/or thermal cracking. The aim of this study consists in correlating microstructure of 4 roll grades with resistances against solicitations. At the laboratory level, solicitations are decoupled in order to better study the impact of microstructural parameters on damage mechanisms. After highlighting grade microstructural differences through numerous parameters (such as the solidification structure; the type, chemical composition, morphology and distribution of both primary and secondary carbides ; the structure and chemical composition of the matrix,…), we show firstly how these parameters influence grade oxidation mechanisms. Secondly we analyse the impact of these parameters on wear mechanisms against coupled solicitations: abrasion and oxidation on a one side, thermal fatigue ant oxidation on the other side. By weighing these parameters, it will be possible to optimize the microstructure
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Sebastian, Torres Raimon. "Ferrer Saiol, traductor de Pal•ladi." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/283132.
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Aquesta tesi té per objectiu analitzar i comprendre la capacitat de Ferrer Saiol com a traductor de l’Opus agriculturae de Pal•ladi. D’aquesta traducció, redactada pels volts del 1385, en conservem dos exemplars posteriors, un en català (València, Biblioteca Municipal Serrano Morales, 6437) i un en castellà (Madrid, Biblioteca Nacional de España, 10211), que ens ajuden a entendre fins a quin punt Saiol comprèn l’obra llatina i de quines fonts disposava per al seu treball. Dividim aquest estudi en tres seccions. La primera versa sobre la difusió de l’Opus agriculturae durant l’Edat Mitjana i el Primer Renaixement. Incloem la pervivència de l’obra pal•ladiana a la Corona d’Aragó i la traducció del protonotari Ferrer Saiol. En la segona secció analitzem els dos testimonis conservats i la seva filiació; examinem les fonts llatines emprades per Ferrer; i realitzem una anàlisi del tresor lexicogràfic, morfològic i sintàctic, nucli del nostre estudi. La tercera és una edició del llibre primer de l’Opus agriculturae en què incloem el text llatí canònic i les dues versions iberorromàniques.The aim of this thesis is to analyse and to understand Ferrer Saiol's skills as a translator of Palladius' Opus agriculturae. Only two manuscripts of this translation written around 1385 have reached us: one of them, in Catalan, (from Biblioteca Municipal Serrano Morales in Valencia, 6437) and the other one, in Spanish, (from Biblioteca Nacional de España in Madrid, 10211). Both texts help us to discern which Ferrer Saiol’s comprehension of the Latin work was and which sources were followed to make his translation. Our thesis is divided into three parts. The first one deals with Opus agriculturae’s dissemination during the Middle Ages and the First Renaissance. It also includes the presence to the Palladian work in the Kingdom of Aragon as well as Saiol’s translation. The second section analyses both preserved testimonies and their filiation by examining the Latin sources used by Ferrer and it studies their lexicographical, morphological and syntactic treasure, which is the core of our thesis. The third part consists of an edition of the Opus agriculturae first book, that includes the canonical Latin text and both Ibero-Romance versions.
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Lang, Mia E. "Intestinal permeability in the irradiated ferret." Thesis, University of Ottawa (Canada), 1991. http://hdl.handle.net/10393/7772.
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Ferrets received whole-body irradiation (5 Gy, gamma). At different times post-irradiation (PIRR, 2, 24, and 48 hours), measurements of fluid and electrolyte fluxes, and of the blood-to-lumen clearance of $\sp{51}$Cr-EDTA, were compared between in situ perfused loops of jejunum and ileum. Intestinal permeation of $\sp{51}$Cr-EDTA was increased (4x control) in both the jejunum and ileum at 2 hours PIRR. At 24 hours PIRR, $\sp{51}$Cr-EDTA permeation was the same as control. At 48 hours PIRR, jejunal permeation of $\sp{51}$Cr-EDTA was not statistically different from control animals, whereas in the ileum, $\sp{51}$Cr-EDTA permeation was increased 10x control. Absorption of luminal fluid was abolished 2 hours PIRR in the ileum. Sodium and chloride fluxes were unaffected by radiation exposure, but at 48 hours PIRR there was a significant secretion of potassium in the ileum. Diarrhea rarely occurred after the first hour post-irradiation. Serotonin, acting via 5-HT$\sb3$ receptors, was investigated as a possible mediator of radiation-induced alterations in intestinal permeability. Pretreatment with the 5-HT$\sb3$ antagonist and anti-emetic BRL 43694 significantly reduced the severity of radiation-induced vomiting. It offered some therapeutic benefit to radiation-induced diarrhea. However BRL 43694 pretreatment had no effect on intestinal permeability. (Abstract shortened by UMI.)
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Mrsic-Flogel, Thomas D. "Development of the ferret auditory cortex." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249548.
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Harper, M. S. "Anatomical organisation of ferret auditory complex." Thesis, University of Aberdeen, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.592545.
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A combination of techniques were used to sub-divide the auditory cortex of the ferret. The primary auditory cortex (AI) could be identified as an area of dense myelin, acetylcholinesterase and succinate dehydrogenase staining with high 2-deoxyglucose activity which could be reduced by ablation of the inferior colliculus and which contained three callosally labelled bands which ran in a dorsoventral direction orthogonal to the isofrequency contours. In addition, up to five secondary auditory fields were also identified: (1) A ventroposterior area (VP) which had dense myelin, acetylcholinesterase and succinate dehydrogenase staining, high 2-deoxyglucose activity which could be reduced by ablation of the inferior colliculus and was reciprocally connected to AI. (2) A ventroanterior area (VA) which had dense myelin staining, high 2-deoxyglucose activity which could be reduced by ablation of the inferior colliculus and was reciprocally connected to AI. (3) An area around the suprasylvian gyrus/suprasylvian sulcus (A) which had dense myelin and succinate dehydrogenase staining, high 2-deoxyglucose activity which may be reduced by ablation of the inferior colliculus and was reciprocally connected to AI. (4) An area on the gyrus dorsal to the suprasylvian gyrus (M) which had dense myelin staining and was reciprocally connected to AI. (5) An area ventral to VP (V) which was reciprocally connected to AI. The density of certain neurochemicals, thought to be involved in plasticity, was also studied in ferret AI during development.
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Smith, Lorraine M. "Magnesium transport in ferret red cells." Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/20802.
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Magnesium transport across membranes was investigated in ferret red cells. Both Mg efflux and influx were measured. Mg transport was found to have the following properties. 1. Mg efflux from unloaded, untreated ferret red cells is 44 ± 2 μmol (1 cell)-1h-1 (mean ± S.E.M. n = 38). 2. Mg efflux is partially inhibited by amiloride, quinidine, quinine, imipramine and divalent cations. Efflux is stimulated by SITS (4-acetamdio-4'-isothiocyanato-stilbene-2,2'-disulfonic acid) and unaffected by vanadate. 3. Mg efflux is stimulated by the depletion of cell ATP. Reducing the cell ATP content reduces the Mg buffering capacity of the cells and thus increases the internal free Mg concentration ([Mg2+]i). This increase in [Mg2+]i may account for some of the stimulation of Mg efflux. 4. Reducing external Na ([Nao]) from 145 to 10 mM (Na replaced with choline choride) stimulates Mg efflux. However Mg efflux is inhibited when [Nao] is below 10 mM. Net uptake of Mg is measured when [Nao] is maintained below 1 mM even if the extracellular medium contains only contaminant Mg (Mg is transported against its electrochemical gradient). Changes in the membrane potential are not responsible for this net uptake. These results show that the system is capable of reversing direction and mediating active transport. 5. Net Mg uptake in media with low [Nao] is stimulated when [Mgo] is greater than 1 mM. The stimulated uptake is partially inhibited by amiloride, quinidine, imipramine, NEM (N-ethylmaleimide) and cobalt. Net uptake is stimulated by vanadate and inhibited by reducing cell ATP.
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Hine, Jemma Elizabeth. "Free-field binaural unmasking in ferrets and humans." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358701.
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Shavila, Joseph. "The toxicological significance of fatty liver in ferrets." Thesis, University of Surrey, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280375.
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Wang, Qing Yuan. "Etude de la fatigue gigacyclique des alliages ferreux." Châtenay-Malabry, Ecole centrale de Paris, 1998. http://www.theses.fr/1998ECAP0693.
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La présente étude porte sur le comportement en fatigue des très grandes durées de vie des alliages ferreux a hautes performances (fontes GS, tôles minces et aciers a très haute résistance). Outre la mise au point de trois machines d'essai piézoélectriques adéquates, de nombreux essais de fatigue sont réalisés sur plusieurs métaux et avec différents profils d'éprouvette. En particulier, une nouvelle possibilité d'essai de fatigue vibratoire a été développée pour permettre l'étude de la limite d'endurance de tôle mince et le seuil de propagation de fissure sur les éprouvettes plates de très faible épaisseur. Nous présentons dans ce mémoire les résultats d'endurance d'une fonte GS 52, d'une tôle mince et des aciers à très haute résistance. Les résultats à 20khz sont en accord avec ceux obtenus à 25 Hz par Renault entre 5 10 5 et 10 7 cycles dans le cas ou la comparaison est possible, ce qui montre que la fréquence de la fatigue vibratoire est sans influence sur l'endurance. Les résultats montrent de plus, qu'entre 10 6 et 10 9 cycles l'asymptote présumée de la courbe de Wöhler est faiblement inclinée et non pas horizontale, et qu'il y a rupture par fatigue jusqu'a 10 9 cycles pour la fonte, tôle mince, les aciers a ressort et les aciers de construction mécanique. On a pris conscience du risque de considérer la limite de fatigue à 10 7 cycles seulement. Dans cette étude, on a mesure aussi l'évolution de la température de l'éprouvette a cause de l'absorption d'énergie ultrasonique au cours des essais. Les résultats montrent que l'endurance en fatigue vibratoire ne produit pas d'augmentation brutale de la température sauf en fatigue oligocyclique. Il y a une élévation rapide a proximité de 10 6 cycles.
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Auphan, Étienne. "Quel avenir pour les réseaux ferrés d'Europe occidentale ? /." Paris : Ed. du Centre national de la recherche scientifique, 1991. http://catalogue.bnf.fr/ark:/12148/cb35478558t.
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Ferrer, Ferrer Maura [Verfasser], and Alexander [Gutachter] Dityatev. "Mental retardation-related protease neurotrypsin in spinogenesis, synaptic plasticity and learning / Maura Ferrer Ferrer ; Gutachter: Alexander Dityatev." Magdeburg : Universitätsbibliothek Otto-von-Guericke-Universität, 2019. http://d-nb.info/1220036064/34.
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Matos, Anselmo Junio Pedroso. "Controle de qualidade físico-químico de uma formulação de pomada orabase de Libidibia ferrea ex. Caesalpinia ferrea L." Universidade Federal do Amazonas, 2016. http://tede.ufam.edu.br/handle/tede/5663.
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Herbal medicines are obtained from medicinal plants, and represent a therapeutic option for the treatment of various diseases. The plant species Libidibia ferrea (L. ferrea) ex. Caesalpinia ferrea L is popularly used and has healing, antifungal and antimicrobial effects scientifically proven. Previous studies have determined the minimum inhibitory concentration of L. ferrea extract that can inhibit the growth of microorganisms present in the oral cavity, which allowed establishing the final concentration of dry matter in the formulation of an ointment containing as active ingredient L. ferrea. The overall objective of this study was the physical-chemical quality control of a orabase ointment formulation of Libidibia ferrea. This is an experimental, controlled, "in vitro" study. Plant samples were derived from the National Institute for Amazonian Research (INPA) and transported to the Faculty of Pharmaceutical Sciences (FCF) of the Federal University of Amazonas (UFAM) for the processing and production of dry extract. For physico-chemical evaluation, centrifuge tests, pH, mass, relative density, microbiological evaluation and organoleptic character of contaminants tests were performed. The physical conditions tested storage were: room temperature (± 25.9 ° C), room temperature, protected from light (± 28.8 ° C) and air conditioning (± 23.7 ° C), the experimental periods were 0, 30 and 60 days. The results of the pH test were analyzed by ANOVA and t-test (p <0.05). The analysis of other results was made using descriptive statistics. The results showed that in the centrifugation test, phase separation was observed at all times (0, 30 and 60 days) and in all storage environments. On the pH test, only the formulation stored at room temperature got a lower pH value, mean (1.95) after 60 days of manipulation. The density test showed the average value of 0.809 g / cm³ when at time 0 and after 30 days of formulation air conditioning values (0,746g / cm³), room temperature (0.702 g / cm³) and room temperature, protected from light, dark (1.022 g / cm³). The evaluation of contaminants showed that there was no bacterial growth in any environment and experimental time, but macroscopically was observed the growth of cotton wool colonies compatible with fungal colonies in stored formulation air conditioning in time of 30 days, and all storage locations time 60 days. On the organoleptic assessment, the ointment showed changes after 60 days of formulation. Based on the results, the formulation tested maintained a better stability of the tested characteristics when stored at room temperature in the dark (dark), however, after 60 days of storage the formulation presented chemical and physical instability and growth of contaminants.
Os fitoterápicos são medicamentos obtidos de plantas medicinais e, representam uma opção terapêutica para o tratamento de diversas enfermidades. A espécie vegetal Libidibia ferrea (L. ferrea) ex. Caesalpinia ferrea L é utilizada popularmente e apresenta atividades cicatrizante, antifúngica e antimicrobiana cientificamente comprovadas. Estudos anteriores determinaram a concentração inibitória mínima do extrato L. ferrea capaz de inibir o crescimento de microrganismos presentes na cavidade bucal o que possibilitou estabelecer a concentração final do extrato seco na formulação de uma pomada contendo a L. ferrea como princípio ativo. O objetivo geral do presente estudo foi realizar o controle de qualidade físico-químico de uma formulação de pomada orabase de Libidibia ferrea. Trata-se de um estudo experimental, “in vitro”, controlado. As amostras vegetais foram oriundas do Instituto Nacional de Pesquisa da Amazônia (INPA) e transportadas para a Faculdade de Ciências Farmacêuticas (FCF) da Universidade Federal do Amazonas (UFAM), para o processamento e produção do extrato seco. Para avaliação físico-química foram realizados os testes de centrifugação, pH, densidade relativa de massa, avaliação microbiológica de contaminantes e caracteres organolépticos. As condições físicas de armazenamento testadas foram: temperatura ambiente (±25,9°C), temperatura ambiente ao abrigo da luz (±28,8°C) e ar-condicionado (± 23,7°C), nos períodos experimentais, 0, 30 e 60 dias. Os resultados do teste de pH foram analisados pelo teste ANOVA e teste-t (p < 0,05). A análise dos demais resultados foram analisados através da estatística descritiva. Os resultados mostraram que no teste de centrifugação, foi observada a separação de fases em todos os tempos (0, 30 e 60 dias) e ambientes de armazenamento; no teste do pH, apenas a formulação armazenada em temperatura ambiente obteve um valor de pH mais baixo, média de (1,95) após 60 dias de manipulação; a densidade apresentou o valor médio de 0,809 g/cm³ quando no tempo 0 e após 30 dias de formulação os valores arcondicionado (0,746g/cm³), temperatura ambiente (0,702 g/cm³) e temperatura ambiente ao abrigo da luz, escuro (1,022 g/cm³); na avaliação de contaminantes não houve crescimento de bactérias em nenhum ambiente ou tempo experimental, porém foi observado macroscopicamente o crescimento de colônias algodonosas compatível com colônias de fungos na formulação armazenada em ar-condicionado no tempo de 30 dias, e em todos os locais de armazenamento no tempo de 60 dias; na avaliação organoléptica, a pomada apresentou alterações após 60 dias de formulação. Com base nos resultados, a formulação testada manteve melhor estabilidade quanto às características testadas quando armazenada em temperatura ambiente ao abrigo da luz (escuro), no entanto, após 60 dias de armazenamento a formulação apresentou instabilidade químico-fisica e crescimento de contaminantes.
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Partosoedarso, Elita Roosi. "An electrophysiological study of vagal reflex pathways activated by upper gastrointestinal stimuli." Title page, contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09php274.pdf.
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Additional appendix (5 p.) is pasted onto back end-paper. Bibliography: leaves 219-244. Investigates the complexity of the vagal reflexes arising from the upper gastrointestinal tract by recording single unit vagal afferents and efferents in the ferret. The potential involvement of various neurotransmitters in mediating and modulating gastrointestinal tract inputs is also explored.
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Sangrà, Boladeres Antonio. "El pintor Agustí Ferrer Pino (1884-1960)." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/285168.
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Una primera aproximació d’aquest estudi, molt preliminar, la vam fer quan varem presentar la tesina l’any 2008. El resultat final, però, el presentem en aquest treball en el que procurarem mostrar, estudiar i analitzar la vida artística i l’obra d’Agustí Ferrer Pino, fins aquest moment quasi bé inèdita. Podríem dir que intentarem rememorar un pintor pràcticament desconegut en l’àmbit català i poc reconegut en la seva població d’origen, Sitges. Potser pel tipus d’obra, per les seves circumstàncies, per com era ell, per haver estat de Sitges... mai no acabat de quallar un nom i una obra dispersa en les col•leccions particulars de moltes famílies sitgetanes. Ara que hem descobert el seu fosc amagatall volem il•luminar-lo amb un estudi en profunditat, de la mateixa manera que altres pintors més o menys emparentats cronològica i conceptualment també l’han tingut.
El present treball s’estructurarà en tres volums:
El primer volum, que abraçarà el cos total del treball sobre Agustí Ferrer Pino, estarà dividit en dues parts. En la primera part es desenvoluparà el marc històric i estètic en el que s’inscriu gran part de la trajectòria artística d’Agustí Ferrer. Essencialment, s’estudiarà el període noucentista de començaments del segle XX a Catalunya, però sense oblidar les altres corrents estètiques que cohabitaren i s’interpel•laren durant el Noucentisme. En aquesta primera part, també li voldrem dedicar una especial atenció al context artístic que configura a Sitges com una població important en el mapa cultural de la Catalunya de començaments de segle. En la segona part entrarem a fons en l’estudi i anàlisi d’Agustí Ferrer i la seva obra. També, com a pintor muralista, pretenem dedicar un espai diferencial a la localització i estudi de les seves pintures murals més importants.
En el segon volum es presentarà la proposta d’una primera catalogació de l’obra d’Agustí Ferrer Pino (dibuix i pintura).
En el tercer i últim volum es presentarà l’apèndix documental de la relació d’articles localitzats en diaris i revistes referents a Ferrer Pino, els seus escrits inèdits i la seva documentació, que haurem fet servir per la construcció d’aquesta tesi.
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Bizley, Jennifer K. "Organisation and function of ferret auditory cortex." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418558.
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Aguinaga, Jean-François. "Francisco Ferrer et l'école moderne de Barcelone." Paris 10, 1993. http://www.theses.fr/1993PA100103.
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Cette thèse présente trois éléments: contexte géopolitique et histoire dans lequel évolue l'école moderne de Barcelone; la vie et l'oeuvre de Ferrer de 1907 à 1909; les hommages publics (rues, places en France) à la mémoire de Ferrer et leur éventuel corrélation avec des initiatives éducatives posthumes inspirées par l'école moderne de BarceloneThis research presents three lines: geopolitical and historical frame of the Barcelona modern's school; the life and production of Ferrer since 1907 to 1909; the public honours (streets, places in France) due to Ferrer's memory and their casual relationship with educationnal creations after Ferrer's death inspired by the Barcelona modern school
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Hammond-Kenny, Amy J. "Multisensory processing in the ferret auditory cortex." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:4e9a731e-4001-4e88-8ffb-7c0c7317050a.
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Our perception of events depends on the integration of information derived from different sensory modalities. Functional imaging and electrophysiological studies have shown that multisensory interactions occur even at the level of primary sensory cortices; however their functional significance remains elusive. Therefore, to explore the relationship between multisensory interactions in early auditory cortical processing areas and behaviour, we recorded activity from the auditory cortex during the performance of different auditory-visual tasks. Ferrets were trained by positive operant-conditioning to localise auditory, visual and spatiotemporally coincident auditory-visual stimuli throughout the frontal hemifield and to categorise temporally coincident auditory-visual stimuli according to their spatial congruency. Our results show that the integration of auditory and visual cues results in significantly more accurate and faster localisation responses and that spatial information can be used to merge different sensory stimuli and resolve conflicts between them. This confirmed the ferret as a good model to explore multisensory spatial processing. In total, 509 single units were identified in the auditory cortex of five animals, of which 16% were influenced by visual stimulation. Our results show that modulation of activity in response to changes in auditory stimulus characteristics directly relates to task performance. For example, animals were more likely to correctly localise stimuli when activity increased in the contralateral cortex and decreased in the ipsilateral cortex. The effects of visual co-stimulation were subtle, mainly suppressive and not clearly correlated with performance on either task. A population decoding analysis showed that auditory cortical activity is, however, informative about the task context, since we were able to decode task type from trials that were otherwise equivalent in terms of the stimuli presented. Our results support the existence of multisensory interactions in early auditory processing areas, but suggest that these areas function primarily as auditory feature detectors that operate in a task-dependent manner.
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Goetz, Damien. "Exploitation sélective de gisements massifs de métaux non ferreux." Phd thesis, École Nationale Supérieure des Mines de Paris, 2000. http://pastel.archives-ouvertes.fr/pastel-00578193.
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Les exploitations minières sont confrontées à des marchés concurrentiels difficiles, avec des prix des matières premières plutôt en décroissance sur le long terme et pour certains particulièrement instables. Ceci conduit les opérateurs à rechercher de nouvelles approches de l'exploitation, avec deux objectifs : d'abord tirer un meilleur profit de leur gisement; ensuite disposer d'une capacité de réaction, d'adaptation à des conditions changeantes.Ces deux objectifs conduisent à s'intéresser à la teneur de coupure. Ce paramètre essentiel définit la limite entre minerai et stérile. Il est utilisé au stade de l'étude du projet minier et sert alors à la définition des contours du gisement industriel.
L'ide développée dans ce document repose sur le fait que lorsque ce paramètre est appliqué à un volume de petite dimension, il peut être ajusté à court terme et permet une sélection plus efficace (en ce sens qu'à un niveau équivalent de récupération de métal, il permet d'écarter un tonnage plus important de matière). Cette idée conduit à proposer un modèle, dérivé des modèles par étapes limitantes, de détermination de la teneur de coupure optimale pour ce type d'exploitation, qualifiées ici de sélectives. Les difficultés de la mise en œuvre, qu'il s'agisse de difficultés liées à l'estimation géologique ou à la planification à court terme de l'exploitation, sont également abordées.
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Di, Curzio Domenico. "Preclinical treatments for hydrocephalus in juvenile ferrets and rats." BioMed Central, 2013. http://hdl.handle.net/1993/31647.
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Hydrocephalus is a common neurological condition characterized by altered cerebrospinal fluid (CSF) flow that results in ventricular expansion due to an accumulation of CSF inside the cranial vault. It is the second most frequent congenital neurologic malformation, but it can manifest at any age, as it is associated with multiple acquired etiologies related to CSF blockage or impaired CSF absorbance. The type and severity of brain damage is dependent on the age of onset, the rate of ventricular enlargement, the magnitude of ventriculomegaly, and how near the impaired brain structure(s) is/are to the cerebral ventricles.
The purpose of this thesis was to gain an understanding of potential pharmacological therapies for treating pediatric hydrocephalus that are aimed to supplement commonly used surgical procedures, such as ventricular shunting and endoscopic third ventriculostomy (ETV). In this endeavour, we experimentally induced hydrocephalus by injection of kaolin (aluminum silicate) into the cisterna magna of juvenile rats at 3 weeks age and ferrets at 2 weeks age to mimic the human condition in infants and children. Prior to drug testing, we characterized the ferret model of hydrocephalus and examined the behavioural, brain structural, cellular, and neurobiochemical changes associated with the condition. From there, we treated hydrocephalic rats for 2 weeks with a combination of antioxidant agents, including α-tocopherol, L-ascorbic acid, coenzyme Q10 (CoQ10), reduced glutathione, and reduced lipoic acid to determine if they showed any improvements compared to sham-treated hydrocephalic rats. Afterwards, we used MgSO4 to treat hydrocephalic ferrets for 2 weeks and compared their outcome to sham-treated hydrocephalic ferrets. In both experiments, the pharmacological therapies did not show any significant biochemical and neurological benefits, nor did the animals improve behaviourally compared to sham-treated animals. Overall, it is suggested that therapeutic benefits were not observed in these studies potentially because ventriculomegaly was not severe enough, the route and/or timing of treatment was not maximally effective, or these treatments should be supplemented with surgical interventions to determine their potential synergistic effects, which would be expected to be implemented in the clinical setting. In conclusion, surgical procedures for treating hydrocephalus are rife with complications, which adds to its morbidity and mortality, so it is important to investigate new therapeutic avenues to effectively treat and hopefully cure hydrocephalus one day.October 2016
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Ait, Maamar Rachid. "Systeme expert temps réel pour l'hydrométallurgie des non ferreux." Paris 13, 1996. http://www.theses.fr/1996PA132023.
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Ce mémoire est consacré au développement d'un système expert temps réel sur deux procédés d'hydrométallurgie du zinc. Nous présentons tout d'abord une description génétique des systèmes experts puis nous nous intéressons plus particulièrement aux systèmes experts temps réel. Connectes directement au procédé, ils nécessitent un couplage a un traitement préalable des données mesurées. Nous proposons alors des méthodes de détection, localisation et correction éventuelle de ces paramètres au moyen de tests statistiques et d'une validation des données par équilibrage de bilans. Nous détaillons ensuite les applications développées sur les deux sites de production. Nous montrons, dans différentes situations, qu'elles fournissent des résultats satisfaisants plusieurs dizaines d'heures avant l'obtention des mesures réalisées classiquement. Nous vérifions également que les diagnostics et solutions pressentis par le système sont en adéquation avec les raisonnements des experts
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Malarte, Guillaume. "Voie d'oxydation aérobie du fer ferreux chez Acidithiobacillus ferrooxidans." Aix-Marseille 1, 2005. http://www.theses.fr/2005AIX11055.
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Acidithiobacillus ferrooxidans est un organisme acidophile chimiolithotrophe qui tire son énergie de l'oxydation du fer ferreux, du soufre élémentaire et de différents composés réduits du soufre. Cette bactérie est utilisée dans le processus de biolixiviation qui permet l'extraction industrielle de métaux précieux. L'étude de la voie d'oxydation du fer ferreux nous a permis de mettre en évidence les différentes métalloprotéines impliquées dans les transferts d'électrons : le cytochrome c4 CYC41, le cytocrome c Cyc2, la rusticyanine et la cytochrome c oxydase. Nous avons réalisé la mise au point de la synthèse hétérologue de CYC41 chez la bactérie neutrophile E. Coli afin d'étudier le mode de repliement de ce cytochrome. La résolution de la structure tridimentionnelle de CYC41 nous a permis de déterminer les mécanismes impliqués dans la stabilisation de ce cytochrome à pH acide. Nous avons montré que CYC41 intervient dans le transfert d'électron entre la rusticyanine et la cytochrome c oxydase selon un modèle de type "electron wire". Une étude intégrée nous a permis de mettre en évidence que les métalloprotéines impliquées dans la voie d'oxydation du fer ferreux sont organisées en super-complexe. Ce résultat est en accord avec les données génétiques puisque l'ensemble des gènes codant pour ces métalloprotéines sont organisées au sein de l'opéron rusAcidithiobacillus ferrooxidans is a chimiolithotrophic organism which used ferrous iron, elemental sulphur and reduced sulphur compounds like energy source. This bacterium is used in the industriel processus of biolixiviation for precous metals extraction. Studie of the iron oxidation pathway has enabled to characterize differents metalloproteins involved in the electron transfer : cytochrome c4 CYC41, cytochrome c Cyc2, rsticyanin and cytochrome c oxidase. We have performed the heterologue synthesis of CYC41 in the neutrophilic bacterium E. Coli to study le folding mechanism of this cytochrome. 3D structure resolution of CYC41 has enabled to determine mechanisms involved in the stabilisation of this cytochrome at acidic pH. We have shown that CYC41. Transfer electrons from rusticyanin to cytochrome c oxidase with an “electron wire” mechanism. We have shown that all metalloproteins involved in the ferrous iron oxidation pathway are organised in a super-complex structur. Our results are agree with the genetic organisation metalloproteins coding genes in the rus operon
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Petit, Grostabussiat Sophie. "Conséquences mécaniques des transformations structurales dans les alliages ferreux." Lyon, INSA, 2000. http://theses.insa-lyon.fr/publication/2000ISAL0117/these.pdf.
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Ce travail s'inscrit dans un programme de recherche qui vise l'analyse des contraintes résiduelles dans la zone affectée thermiquement (ZAT) après une opération de soudage sur l'acier de cuve (16MND5 dans la norme AFNOR), des centrales nucléaires de type REP (Réacteurs à Eau Pressurisée). Deux dispositifs expérimentaux sont utilisés dans des études à deux échelles, du matériau et de la structure. A l'échelle du matériau, nous nous intéressons particulièrement à l'évaluation des conséquences mécaniques des transformations structurales au refroidissement : plasticité de transformation, plasticité classique multiphasée et restauration d'écrouissage en cours de transformation. Une étude de l'interaction plasticité classique plasticité de transformation est également réalisée. Il est montré que, pour une même charge appliquée, la plasticité de transformation est plus importante dans une transformation bainito-martensitique par rapport à une transformation unique. Il est également montré que, dans le cas où la phase austénitique subit un écrouissage avant sa transformation en bainite, il semblerait qu'une partie très importante de cet écrouissage est transmise à la bainite en cours de transformation. De plus, les résultats montrent l'importance de l'interaction entre la plasticité classique et la plasticité de transformation. Ainsi, il est clairement mis en évidence que la plasticité de transformation peut intervenir sans charge extérieure appliquée si la phase austénitique est pré-écrouie avant sa transformation. Le sens de l'écoulement n'est pas toujours celui auquel on pourrait s'attendre en considérant les modèles classiques. Ce phénomène est plus significatif dans le cas de la transformation martensitique. En plasticité multiphasée, une fonction empirique est proposée en vue de l'évaluation de la contrainte dans un mélange en cours de transformation. A l'échelle de la structure, des essais sont réalisés sur un disque chauffé axisymétriquement en son milieu de manière à obtenir une ZAT. Une simulation numérique à l'aide du Code_Aster d'E. D. F. (Electricité De France), qui tient compte des interactions thermique -mécanique -métallurgie, est réalisée et les résultats sont comparés aux mesures expérimentales (température, déplacements, contraintes résiduelles, …). Nous retiendrons essentiellement l'importance de la prise en compte de la plasticité de transformation pour l'évaluation des contraintes résiduellesThis work deals with the assessment of residual stresses, in the Heat Affected Zone (HAZ), after a welding process in a 16MND5 steel (used in the French nuclear power plants). Two experimental devices are used to perform some analyses related to the material and the structural scales. For the material scale, we are interested in the evaluation of the mechanical consequences of phase transformations during cooling : transformation induced plasticity (TRIP), classical elastoplastic behaviour when the material is composed of two phases and the recovery phenomenon during the transformation. The interaction between classical plasticity and TRIP is also considered. It is shown that, for the same applied load, the TRIP is more significant in a double transformation (bainite + martensite) compared to a single transformation. It is also shown that, if the austenitic phase is hardened before its transformation into bainite, it seems that a very significant part of this hardening is transmitted to the bainite during the transformation. Moreover, the results show the importance of the interaction between classical plasticity and TRIP. For the classical elastoplastic behaviour, an empirical function is proposed in order to enable the evaluation of the stress in a mixture (austenite + ferritic phase) during transformation. For the structural scale analyses, tests were carried out considering a disc heated axisymetrically in its medium in order to have a HAZ. Numerical simulations using the finite element code, Code_Aster (which takes into account the interactions between the thermal, the mechanical and the metallurgical phenomena), developed by Electricité de France, were also performed. . The numerical results were compared to the experimental measurements (temperatures, displacements, residual stresses. . . ). From this comparison, the significant role played by the TRIP in the assessment of the residual stresses, is clearly shown
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Silva, Volnir de Oliveira. "Estudos cinéticos da catálise da reação de fenton por 3,5-di-terc-butil-catecol." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/46/46132/tde-05022013-140557/.
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A reação de Fenton é o nome dado à oxidação de ferro(II) a ferro(III) pela água oxigenada, uma reação que produz espécies com alto poder oxidante como o radical hidroxila. Neste trabalho, foi desenvolvida uma metodologia espectrofotométrica para o acompanhamento da formação de ferro(III) nos momentos iniciais da reação de Fenton. Esta metodologia foi aplicada a quatro conjuntos de reações: (A) o sistema Fenton simples, contendo apenas ferro(II) e H2O2; (B) o sistema A contendo isopropanol, um substrato orgânico simples que sofre principalmente oxidação a acetona; (C) o sistema A contendo o catalisador 3,5-di-terc-butil-catecol (H2DTBCat); (D) o sistema C mais isopropanol, que corresponde ao sistema catalítico completo. Em cada conjunto, variou-se as concentrações de ferro(II) e H2O2. Um modelo cinético, baseado num conjunto de reações explícitas e as respectivas constantes de velocidade, foi desenvolvido para simular a velocidade de formação de ferro(III) para estes quatro conjuntos de reações. Utilizando reações relatadas na literatura, o modelo forneceu simulações que reproduziram satisfatoriamente os dados experimentais dos conjuntos A e B. No caso dos conjuntos C e D, porém, foi necessário propor uma etapa envolvendo a formação de ferro(IV) ou ferril, estabilizado por complexação com o H2DTBCat. Entretanto, mesmo com a inclusão desta espécie, o modelo não captou a complexidade do sistema em altas concentrações de peróxido e ferro. Esta falha foi atribuída à rápida degradação competitiva do H2DTBCat nestas condições, com a subseqüente participação destes produtos de degradação na reação ou como co-catalisadores ou como inibidores.The Fenton reaction is the name given to the oxidation of iron(II) to iron(III) by hydrogen peroxide, a reaction that produces highly oxidizing species like the hydroxyl radical. In this work, a spectrophotometric methodology is developed to accompany the formation of iron(III) during the initial moments of the Fenton reaction. This methodology was applied to four sets of reactions: (A) the simple Fenton system, containing only iron(II) and H2O2; (B) system A containing isopropanol, a simple substrate that undergoes principally oxidation to acetone; (C) system A containing the catalyst 3,5-di-tert-butyl-catechol (H2DTBCat); (D) system C plus isopropanol, corresponding to the complete catalytic system. For each set of reactions, the concentrations of iron(II) and H2O2 were varied. A kinetic model, based on explicit chemical reactions and their respective rate constants, was developed to simulate the the rate of formation of iron(III) for these four sets of reactions above. Using reactions described in the literature, the model produced simulations that satisfactorily reproduced the experimental data of sets A and B. In the case of sets C and D, however, it was necessary to propose an additional step involving the formation of iron(IV) or ferril, stabilized by complexation with H2DTBCat. Nonetheless, even with the inclusion of this species, the model failed to capture the complexity of the system at high concentrations of peroxide and iron. This failure was attributed to the rapid competitive degradation of H2DTBCat under these conditions, with the subsequent participation of the degradation products in the reaction as either co-catalysts or inhibitors.
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Akerman, Colin J. "The development of functional connectivity in the mammalian geniculocortical pathway." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365701.
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Williams, Adrian Lloyd. "Growth dynamics in the developing lateral geniculate nucleus." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313613.
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Baltzinger, Christiane. "Contribution à l'étude du mécanisme de l'attaque des cristaux en relation avec leur structure cas particulier de l'hématite /." Metz : Université Metz, 2008. ftp://ftp.scd.univ-metz.fr/pub/Theses/1974/Baltzingzer.Christiane.SMZ7407.pdf.
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Wagner, Francis. "Contribution à l'étude des figures d'attaque sur les faces {01.2} de l'hématite par microscopie interférentielles et stéréoscopie au microscope électronique à balayage." Metz : Université de Metz, 2008. ftp://ftp.scd.univ-metz.fr/pub/Theses/1973/Wagner.Francis.SMZ7309.pdf.
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Bessières, Jean Baro R. "Application de la méthode de P. Hartman à l'étude théorique et expérimentale de la forme d'équilibre des cristaux d'hématite [alpha]-Fe203." Metz : Université de Metz, 2008. ftp://ftp.scd.univ-metz.fr/pub/Theses/1972/Bessieres.Jean.SMZ7201.pdf.
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Fischer, Ricardo Guimaräes. "The ferret in periodontal research clinical features, histology, microbiology and immunosuppression (Cyclosporin-A) /." Malmö : Dept. of Periodontology, Center for Oral Health Sciences, Lund University, 1993. http://catalog.hathitrust.org/api/volumes/oclc/28161627.html.
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Guzmán, Zorrilla Emanuel Jesús. "Modelamiento de la dispersión de contaminantes pasivos en la bahía Ferrol – Chimbote." Master's thesis, Universidad Nacional Mayor de San Marcos, 2014. https://hdl.handle.net/20.500.12672/3955.
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Se realizó la modelación numérica de dispersión de contaminantes en la bahía Ferrol- Chimbote mediante el desarrollo de un modelo de dispersión basado en la ecuación de advección-difusión para representar el transporte de sustancias en la bahía Ferrol. El modelo fue desarrollado empleando métodos de diferencias finitas y funciona de manera acoplada con el modelo de circulación oceánica Princeton Ocean Model (POM).
Previo a la modelación de dispersión en la bahía y con el modelo de dispersión desarrollado, se realizaron simulaciones de casos teóricos de dispersión ya conocidos con la finalidad de comparar los resultados del modelo numérico con las soluciones analíticas y con esto verificar las bondades de los esquemas numéricos propuestos.
Para llevar a cabo la modelación de manera más realista aplicada a la zona de estudio, en primer lugar se realizó la modelación de la circulación en la bahía forzado con información de viento y marea de la zona de estudios, para esto se empleó el modelo POM con el que se obtuvo la caracterización de corrientes en la bahía a nivel superficial y subsuperficial. Se logró validar el modelo POM de manera adecuada para los cálculos de los niveles del mar, obteniéndose un coeficiente de correlación de 0.77, lo que indica un buen grado de aproximación entre lo modelado y observado. En cuanto a la validación de corrientes, debido a la poca disponibilidad de información tanto en cobertura espacial como temporal, no fue posible realizar una validación más detallada tal como se hizo para el nivel del mar. Sin embargo, los resultados de las corrientes modeladas indican que estas se encuentran en el mismo orden que las corrientes medidas en los diferentes estudios realizados en la bahía.
Habiendo realizado la caracterización de la circulación, se procedió a ejecutar el modelo de dispersión para tres escenarios definidos, donde en el primero de ellos se contemplan las descargas dentro de la bahía (condiciones actuales) mientras que en el segundo y tercer escenario se evalúan las condiciones de dispersión para descargas que se pudieran ubicar fuera de la bahía como alternativas de descontaminación de la bahía Ferrol. Las sustancias modeladas fueron consideradas como “pasivas o conservativas” ya que no forman compuestos adicionales al reaccionar con el agua de mar. Para esto fue necesario recopilar información referente a las características del agua de mar de la bahía, siendo las sustancias a evaluar coliformes totales y aceites & grasas.
Finalmente se observa que el modelo es una buena herramienta para el estudio de los fenómenos de dispersión y que debe de seguir siendo mejorado tanto en el aspecto matemático como en la investigación más profunda de los parámetros y coeficientes que intervienen en la modelación, para lo que se necesita una mayor disponibilidad de la información sobre la calidad de aguas.Tesis
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Costa, Leidyana Moraes da. "Desenvolvimento de produto seco por aspersão obtido a partir das cascas do caule de libidibia ferrea martius var. ferrea (fabaceae)." Universidade Federal do Amazonas, 2012. http://tede.ufam.edu.br/handle/tede/2590.
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Libidibia ferrea popularly known as jucá or pau-ferro is widely used in popular medicine for treatment of diabetes. The tannins are majority chemical constituents. Pharmacological studies, with the stem bark, showed main activities: antimicrobial, hypotensive, vasodilator and hypoglycemiant. This species are inserted in National Formulary Herbal Medicine. The goal of this work is the technological development and characterization of spray dried products from aqueous solution of the stem bark of L. ferrea. The vegetable material of L. ferrea was collected at different times and places from Manaus-AM, being characterized in order to establish parameters for quality control of this species. The dried products were produced using a 23 factorial design, where the independent variable was the type of adjuvant (colloidal silicon dioxide, microcrystalline cellulose and arabic gum) and the dependents variables were biological and technological characteristics of the products obtained. The dried products were evaluated as yielding, residual moisture, rheological properties, morphology, particle size, porosity and behavior in controlled environment with a relative humidity of 65%. In addition, it was evaluated the ability of in vitro inhibition of angiotensin converting enzyme (ACE) and α-glucosidase of the products obtained. Additionally, it was developed and validated an analytical method in liquid chromatography (HPLC) to quantify polyphenols in L. ferrea raw material. The results of raw material characterization demonstrate that were within the limits recommended by the Brazilian Pharmacopoeia. However, there were statistically significant quantitative differences among the samples studied suggesting that climatic conditions change the physico-chemistries characteristics of this species and therefore may influence the quality, efficacy and safety of the products. The HPLC method was validate and it was efficient for the quantification of gallic acid. Considering the dried products the work showed that the adjuvants studied did not contribute to increase the efficiency of dry operation when compared to the dry extract without adjuvant or improve the rheological characteristics. Evaluation of in vitro activity demonstrates that all products from L. ferrea inhibited significantly the enzyme α-glucosidase, however they were no efficient against ACE
A espécie vegetal Libidibia ferrea conhecida popularmente como jucá ou pau-ferro é largamente utilizada pela medicina popular da Amazônia para o tratamento do diabetes. Dentre os seus principais constituintes químicos destacam-se os taninos. Estudos farmacológicos realizados com as cascas do caule demonstraram atividades antimicrobiana, hipotensora, vasodilatadora e hipoglicemiante. A referida espécie está inserida no Formulário Nacional de Fitoterápicos. O presente trabalho refere-se ao desenvolvimento e caracterização tecnológica de produtos secos por aspersão a partir de solução extrativa aquosa das cascas do caule de L. ferrea. O material vegetal de L. ferrea foi coletado em diferentes épocas e lugares de Manaus, sendo caracterizado a fim de auxiliar no estabelecimento de parâmetros para o controle de qualidade dessa espécie vegetal. Os produtos secos foram produzidos através de um delineamento fatorial do tipo 23, tendo como variável independente o tipo de adjuvante de secagem (dióxido de silício coloidal, celulose microcristalina e goma arábica) e como variáveis dependentes as características tecnológicas e biológicas dos produtos obtidos. Dentre os parâmetros tecnológicos avaliados nos pós destacam-se o rendimento operacional, umidade residual, características reológicas, morfologia e granulometria, porosidade e comportamento frente à ambiente com umidade relativa controlada de 65%. Além disso, foi avaliada a capacidade de inibição in vitro da enzima conversora de angiotensina (ECA) e da α-glicosidase pelos produtos obtidos. Adicionalmente, foi desenvolvido e validado método analítico em cromatógrafo a líquido de alta eficiência (CLAE) para a quantificação polifenóis na matéria-prima vegetal de L. ferrea. Os resultados obtidos permitiram observar que os parâmetros estudados estão dentro dos limites preconizados pela Farmacopéia Brasileira. No entanto, todos os demais parâmetros avaliadas evidenciaram diferenças quantitativas estatisticamente significantes entre as amostras estudadas sugerindo que as condições edafoclimáticas alteram as características físico-químicas desta espécie e, portanto, podem influenciar na qualidade, eficácia e segurança de um produto final proposto. O método desenvolvido e validado em CLAE mostrou-se eficiente para a quantificação de ácido gálico, contemplando todos os critérios preconizados. Dentre os adjuvantes utilizados, a análise demonstrou que os adjuvantes adicionados à solução extrativa não contribuíram para um rendimento superior, assim como não proporcionaram melhores características reológicas. Na avaliação da atividade inibitória da α-glicosidase, no modelo experimental in vitro, todos os produtos oriundos da L. ferrea inibiram, significativamente, a enzima α-glicosidase. Em contrapartida, não foi constatada atividade inibitória para a ECA
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Cunha, Arcelina Pacheco. "Caracterização e modificação química da Galactomanana de Caesalpinia Ferrea Mart Ex Tul.Var Ferrea: estudo do potencial antiviral, hipoglicemiante e cicatrizante." reponame:Repositório Institucional da UFC, 2015. http://www.repositorio.ufc.br/handle/riufc/21445.
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CUNHA, Arcelina Pacheco. Caracterização e modificação química da Galactomanana de
Caesalpinia Ferrea Mart Ex Tul.Var Ferrea: estudo do potencial
antiviral, hipoglicemiante e cicatrizante. 2015. 88 f. Tese (Doutorado em Química)-Universidade Federal do Ceará, 2015.Submitted by Aline Mendes (alinemendes.ufc@gmail.com) on 2016-12-20T19:51:14Z No. of bitstreams: 1 2015_tese_apcunha.pdf: 2614453 bytes, checksum: f0c152c111e433ce87017667416ab588 (MD5)
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This study aims to develop polymeric compositions that can be applied to produce antiviral, hypoglycemic and as an aid in the healing of skin lesions. Therefore, the galactomannan from Caesalpinia ferrea seeds were purified, and subsequently modified by a chemical sulfation reaction. Then, purified sulphated galactomannan (JSGp and JSGs) were characterized by the following techniques: Infrared Transform Infrared spectroscopy (FTIR); Thermal Analysis (TG and DSC); Dispersive Energy X Ray (EDX); Scanning Electron Microscopy (SEM); Surface tension; Atomic Force Microscopy (AFM); Zeta potential; Gel Permeation Chromatography (GPC) and studies in rheology, among others. The toxicity of the galactomannans was evaluated for possible pharmacological applications. The following toxicity tests have been applied: assessment of toxicity through bioassays against nauplios Artemia sp; bioassays in vivo using Swiss mice; assessment of toxicity compared to the human neutrophils, as measured by lactate dehydrogenase (LDH) activity. According to the analyzes performed in this study, the purified galactomannan presented a hypoglycemic effect and a promising adjuvant in the healing of skin lesions. The galactomannan modified by sulfating presented antiviral properties against Herpes (HSV1) and polio (PV1) viruses.
O presente trabalho teve como objetivo desenvolver composições poliméricas que possam ser aplicadas como: antiviral, hipoglicemiante e como coadjuvante na cicatrização de lesões dérmicas. Para isso foi realizado uma purificação e modificação de galactomanana de Caesalpinia ferrea Mart ex Tul.Var Ferrea para avaliar o potencial de bioatividade desse polímero purificado e modificado por sulfatação. Após o procedimento de purificação e modificação química, a galactomanana de jucá foi caracterizada por Espectroscopia na Região do Infravermelho (FTIR), Análise Térmica (TGA e DSC), Energia Dispersiva de Raio-X (EDX) e Microscopia Eletrônica de Varredura (MEV), Tensão Superficial, Microscopia de Força Atômica (AFM), Potencial Zeta, Cromatografia de Permeação em Gel (GPC), estudos em reologia, avaliação da toxicidade das galactomananas (nativa, purificada e sulfatada) através dos bioensaios contra náuplios Artemia sp; bioensaios in vivo, utilizando camundongos da raça swiss e avaliação da toxicidade frente aos neutrófilos humanos, mensurada através da atividade da enzima lactato desidrogenase (LDH). Pelas análises realizadas nesse trabalho, o polissacarídeo, do tipo galactomanana, purificado e modificado por sulfatação, apresentou respostas bioativas, como antiviral, contra vírus da Herpes (HSV1) e poliomielite (PV1), hipoglicemiante e promissor coadjuvante na cicatrização de lesões dérmicas.
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Lenzi, Maria Isabel Ribeiro. "Para aprendermos a história sem nos fatigar: a tradição do antiquariado e a historiografia de Gilberto Ferrez." reponame:Repositório Institucional da UFF, 2013. https://appdesenv.uff.br/riuff/handle/1/282.
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A tese tem como objeto de estudo a historiografia de Gilberto Ferrez e como fonte principal os documentos de seu arquivo pessoal existente no Arquivo Nacional, além de suas obras publicadas e pareceres para o SPHAN. O trabalho se insere no campo dos estudos da história da escrita da história e caracteriza como a obra de Gilberto Ferrez exemplifica o antiquariado enquanto forma de construção do conhecimento histórico. Discute também de que maneira esse modelo se mantém atual, contrariando a tendência a vê-lo apenas enquanto uma expressão da Época Moderna. Para definição do antiquariado, nos valemos de conceitos desenvolvidos por Arnaldo Momigliano. Considerando que Gilberto Ferrez também foi um colecionador notório, a pesquisa evidencia de que modo a prática de colecionar se constituiu como a base de sua formação de pesquisador em história, definindo o documento de época, sobretudo imagens, como objeto de estudo principal da História. Ao lado disso, a partir de Michel de Certeau, discute-se o lugar social da construção de sua historiografia, demarcando sua participação no IHGB e no Conselho Consultivo do SPHAN e sua rede de colaboração, descrevendo um ambiente de sociabilidade intelectual marcada por laços pessoais. Em seguida, a tese discute suas práticas de pesquisa, explorando os trabalhos publicados, os pareceres produzidos para o SPHAN e a correspondência mantida com seus pares. É apresentada ainda uma interpretação de sua leitura da história do Brasil como memória da civilização europeia, associada a estrangeiros que viveram no Brasil.
This dissertation discusses Gilberto Ferrez’s historiography. It uses as its main source the documentation from his personal archives preserved at the Arquivo Nacional, and cite as well the works the published and the technical judgements he issued as counselor at SPHAN. This text belongs to the field of studies dealing with the history of historical writing, and considers the manner in which the work of Gilberto Ferrez exemplifies antiquarianism taken as a form of constructio9n of historical knowledge. This dissertation also seeks to discuss how that model remains current, differing from those who tend to consider it only as an expression of the Modern Age. In order to define antiquarianism, we made use of concepts developed by Arnaldo Momigliano. Given the fact that Gilberto Ferrez also was a well-known collector, our research attests how the practice of collecting turned out to provide the foundations for his formation as a researcher in the historical field, choosing historical documents – especially images – as history’s main object of study. Making use of Michel de Certeau’s work, the social place in which Ferrez’s historiography is constructed is also explored, outlining his participation at IHGB and on SPHAN’s advisory board as well as his network of collaborators, disclosing an atmosphere of intellectual sociability characterized by personal tyes. This thesis then proceeds, to discuss his practice in research work, considering the books he published, the technical opinions issued as a counselor for SPHAN and the correspondence he maintained with he peers. Finally this thesis interprets the way in which Ferrez viewed Brazil’s history as a memory of European civilization, closely linked for foreigners who played a relevant role while living in the country.