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Zhang, Zheng-Feng, Tsung-Lung Li, and Ming-Der Su. "Correction: Understanding the reactivity of carbene-analogous phosphane complexes with group 13 elements as a central atom: a theoretical investigation." New Journal of Chemistry 44, no. 35 (2020): 15299. http://dx.doi.org/10.1039/d0nj90117b.
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Correction for ‘Understanding the reactivity of carbene-analogous phosphane complexes with group 13 elements as a central atom: a theoretical investigation’ by Zheng-Feng Zhang et al., New J. Chem., 2020, 44, 12815–12826, DOI: 10.1039/D0NJ01708F.
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Zheng, Feng. "Response to Critique by Feng Zheng." Journal of Controlled Release 55, no. 1 (October 1998): 101. http://dx.doi.org/10.1016/s0168-3659(98)00008-x.
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CAO, CHENG-QUAN, YAN DANG, and ZHAN YIN. "A new species and key to all known species of the genus Ceracris Walker, 1870 from China (Orthoptera: Acridoidea, Arcypteridae)." Zootaxa 4555, no. 2 (February 12, 2019): 275. http://dx.doi.org/10.11646/zootaxa.4555.2.8.
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The genus Ceracris Walker, 1870 is a median genus in Arcypteridae, which contains 23 species in the world, among them 11 species distributed in China [Walker, 1870; Bolivar, 1914; Uvarov, 1931; Zheng, 1977; Liu, 1981; Zheng, 1983; Yin, 1984; Liang, 1988; Wang, 1992; Liu et Li, 1995; Ou et al, 1995; Yin et al, 1996; Zheng et Xia, 1998; Zhang et al, 2017; Feng et al, 2018; Cigliano, 2018]. A new species of the genus from Hainan, China is described in this paper. The new species i.e. Ceracris amplicornis sp. nov. is similar to Ceracris versicolor (Brunner von Wattenwyl, 1893), but differs from latter by antennae short, length of a segment in the middle 2.9 times its width; lateral carinae of pronotum not intact and indistinct in metazona; median area of tegmen without intercalary vein; bridge of epiphallus straight and tegmen of female short, reaching the end of hind femur only. Type specimens are deposited in the Natural Museum of Hebei University, Baoding, Hebei, China.
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Yun, Hye‑ji. "A Brief Analysis on Female Narration Poems of 『Shijing⋅Zheng Feng』." Journal of Chinese Studies 89 (August 30, 2019): 1–31. http://dx.doi.org/10.36493/jcs.89.1.
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Wang, Yuanfei. "The Emaciated Soul: Four Women’s Self-Inscriptions on Their Portraits in Late Imperial China." NAN Nü 22, no. 1 (June 8, 2020): 36–69. http://dx.doi.org/10.1163/15685268-00221p02.
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Abstract This article examines the emaciated self-images of four women’s self-inscription poems on their own portraits. They are Huang Hong (early seventeenth century), Xi Peilan (1760–after 1829), Tan Yinmei (fl. mid-eighteenth to early nineteenth century) and Zheng Lansun (1819-61). These women similarly describe their self-images as qiaocui (emaciated), alluding to the legendary girl poet Feng Xiaoqing. Inherently ambivalent, qiaocui could imply sexual and erotic appeal, the virtuous mind of a recluse, sickness, ordinariness, melancholy, as well as aging and death. The article argues for the importance of the rhetoric of qiaocui and the topoi of Feng Xiaoqing in the self-inscriptions by women in Hangzhou and the broader Jiangnan region as a medium to construct their female subjectivity. This article suggests that, initially a persona publicly circulated in the late Ming, the topoi of Feng Xiaoqing came to define the women’s personhood in private spaces in late eighteenth and early nineteenth centuries.
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Yiqing, Xiang. "A Study on Feng Tang’s Translation of Stray Birds from Manipulation Theory." English Literature and Language Review, no. 56 (June 10, 2019): 89–96. http://dx.doi.org/10.32861/ellr.56.89.96.
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Tagore is a distinguished Indian writer and poet, and his works have never lost popularity around the world. Published in 1916, Stray Birds is one of the earliest translated poetry collections in China, of which the version translated by Zheng Zhenduo is highly regarded. However, Chinese poet Feng Tang translated Stray Birds in 2015 and his version soon became the subject of heated discussions among translation field and academic world due to his unique style and bold diction. Based on Lefevere’s manipulation theory, this essay offers an analysis of Feng Tang’s translation of Stray Birds, analyzing the influence of the manipulative factors, namely ideology, poetics and patronage on Feng’s translation methods and strategies. At present, most criticisms of Feng Tang’s translation focus mainly on translation theories and linguistic factors. From the perspective of manipulation theory, the study on Feng’s translation will not only provide new methods and ideas for the appreciation and translation of poetry, but also add more radiance on Stray Birds.
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Meng, Xiangwei, Xue-ping Gao, Wen-zhong Zhang, and Yun-peng Jiang. "EXPERIMENTAL FORMULA FOR THE WAVE-INDUCED SHIP MOORING FORCE." Coastal Engineering Proceedings 1, no. 32 (January 19, 2011): 61. http://dx.doi.org/10.9753/icce.v32.waves.61.
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The wave force dose not considered at the formula of mooring ship cable force in the Load Code for Harbor Engineering[JTJ215-98]. This brought the inconvenience to the calculation of designed cable force for mooring ship. By means of analysis for the laboratory model test result of mooring ship cable force under wave effect, Wave force formula of mooring ship under wave effect was gained. This formula well reflected the influence of ship size, ship load , ship rolling period, ship pitch period, wave period and wave height. The formula can be used in the calculation of standard value of mooring ship cable force under the wave effection, also it can be used to instruct the wave model test for mooring ship.
References
Zhang Ri-xiang. Liu Zhong-bo. Zhang Ning-chuan. 2003 .An Experimental Study on the Mooring Line Forces & Impact Forces of a Moored Ship Under the Combined Action of Wind,Wave and Current [J].,China offshore Platform, (01).15-18.
Li Yan. Zheng Bao-you.Gao Feng. Meng Xiang-wei.2007.Model test study on the impact forces and mooring line forces of a moored ship under the combined action of wave and current [J].;The Ocean Engineering, (02).57-63.
Ministry of transport of the People's Republic of China(1998).The Load Code for Harbor Engineering(JTJ215-98). [S].
Jiang Qing. Ge Hong-zheng.Xie Peng.2007.Influence of Ship's Type and Tonnage on the Ship's Mooring Force [J]. Port & Waterway Engineering, (09).51-59.
Wu Xiuhuan. 1999.Ship and maneuverability and seakeeping [M]. Ministry of transport of the People's Republic of China. p220.
Zhang Wen-zhong. Etc.(2006): Model test of Mooring LNG ship at Jiangsu Provence, Tianjin Port Engineering Institute Ltd. of CCCC.
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Eve, Angelia. "Reviewer Acknowledgements." Applied Finance and Accounting 1, no. 2 (July 31, 2015): 150. http://dx.doi.org/10.11114/afa.v1i2.996.
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Applied Finance and Accounting [AFA] would like to thank the following reviewers for reviewing manuscripts from February 1, 2015 to July 31, 2015. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Many authors, regardless of whether AFA publishes their work, appreciate the helpful feedback provided by the reviewers. Redfame Publishing appreciates the following reviewers’ rigorous and conscientious efforts for this journal. Each of the reviewers listed below returned at least one review during this period. Abdelaziz HAKIMI Adam Zaremba Ana Iglesias-Casal Anastasia,Kopaneli Aneta Karina Bernat Augustine Akhidime Desti Kannaiah Feng Jui Hsu Florin Peci Ghazi Alassaf Gheorghe Morosan Haitham Nobanee, Hajar Jahangard Hong Bo Kesseven Padachi Lee Kian Tek Luca Sensini Luo Yongli Marco Muscettola Mazurina Mohd Ali Meri Boshkoska Mohamed Jalloh Nicoleta Radneantu Nikolay Patonov Noriaki Okamoto Odumeso-Jimoh M I John Peibiao Zhao Wei-Bin ZHANG Wilson E. Herbert Rui FERNANDES Shahram Fattahi Vineet Chouhan Yao Zheng Yu Peng Lin
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Eve, Angelia. "Reviewer Acknowledgements." Applied Finance and Accounting 1, no. 1 (January 26, 2015): 60. http://dx.doi.org/10.11114/afa.v1i1.656.
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Applied Finance and Accounting (AFA) would like to thank the following reviewers for reviewing manuscripts from August 30, 2014, to January 30, 2015. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Many authors, regardless of whether AFA publishes their work, appreciate the helpful feedback provided by the reviewers. Redfame Publishing appreciates the following reviewers’ rigorous and conscientious efforts for this journal. Each of the reviewers listed below returned at least one review during this period. Abdelaziz HAKIMI Adam Zaremba Anastasia, Kopaneli Aneta Karina Bernat Feng Jui Hsu Florin Peci Gheorghe Morosan Haitham Nobanee Hong Bo Kesseven Padachi Lee Kian Tek Luca Sensini Luo Yongli Marco Muscettola Mohamed Jalloh Nikolay Patonov Noriaki Okamoto Odumeso-Jimoh M I John Peibiao Zhao Rui FERNANDES Shahram Fattahi Vineet Chouhan Wei-Bin ZHANG Yao Zheng Yu Peng Lin Angelia Eve Editorial Assistant On behalf of, The Editorial Board of Applied Finance and Accounting Redfame Publishing 9450 SW Gemini Dr. #99416 Beaverton, OR 97008, USA E-mail: afa@redfame.com URL: http://afa.redfame.com
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Shao, Qing, and Xuesong Gao. "‘Noisy guests shall not unseat the host’." English Today 33, no. 3 (July 26, 2016): 25–30. http://dx.doi.org/10.1017/s0266078416000419.
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There have been growing concerns in recent years about the status of English in China, the most populous country that boasts the largest number of English speakers and learners (Bolton & Graddol, 2012; Wang, 2015). Such concerns are closely associated with the rising importance of the Chinese language worldwide, which seems to signal that ‘English is no longer so important’ (Wei & Feng, 2015: 59). The Chinese government has become much more active in promoting Chinese as an international language through the establishment of Confucius Institutes worldwide. The concerns about the status of English have also been related to the growing assertiveness of China's nationalism. In September 2013, a former spokesman of the Ministry of Education appealed to the public to emancipate children from English and save the Chinese language (Zheng, 2014). In October 2013, the Beijing Municipal Commission of Education announced that the weighting of the English section in the Beijing version of Gaokao, the national university matriculation examination, would be reduced to 100 from 150, starting from 2016. In the meantime, the weighting of Chinese will be increased to 180 (Wei & Feng, 2015). In March 2016, the Beijing Education Examination Authority finalized the decision and set the weighting of Chinese and English in Gaokao to 150 in 2016 (Beijing Education Examination Authority, 2016). In addition to Gaokao, critics have openly challenged whether satisfactory College English Test (CET®) results should be used as a prerequisite for degree conferment in many Chinese universities (Xie, 2014).
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Akther, Jasmeen, Chaojie Song, Ken Tsay, Khalid Fatih, and Peter Pickup. "Room Temperature, Ambient Pressure Synthesis of Urea By Electrolysis and Its Accurate and Consistent Measurement." ECS Meeting Abstracts MA2022-01, no. 55 (July 7, 2022): 2330. http://dx.doi.org/10.1149/ma2022-01552330mtgabs.
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There is rapidly growing interest in the electrochemical reduction of both nitrite and carbon dioxide to mitigate environmental concerns and produce fuels and commodity chemicals (1). Urea is an important target in this area since it is the most widely used nitrogen fertilizer, and can also be used as a fuel and source of hydrogen. It can be produced simultaneously by electrochemical coreduction of NO2 - and CO2 (2-7). Various TiO2 based catalysts such as Cu-doped TiO2 (7) and FeTiO3 (4) have been reported to be effective for co-reduction of CO2 and NO2 -. Metallophthalocyanine catalysts have also been found to be effective in a gas-diffusion electrode configuration under ambient conditions (3). The primary objective of this research is to develop fast and straightforward methodologies that can be routinely used to comprehensively evaluate and compare commercial and new catalysts for co-electrolysis of CO2 and NO2 - in an anion exchange membrane multi-cathode electrolysis cell under ambient conditions. The second objective is using this methodology to synthesize urea and develop reliable and consistent urea measurement methods using various techniques including spectrophotometric, 1H-NMR, mass spectrometry, and enzyme-based methods. It was found that NO2 - and the electrolyte can cause interference during urea measurement. In this research, commercial catalysts such as iron (II) phthalocyanine were used for co-electrolysis of CO2 and NO2 -. Acknowledgements This project is funded in part by the Government of Canada. / Ce projet est financé en partie par le gouvernement du Canada, and by Memorial University References C. Tang, Y. Zheng, M. Jaroniec and S. Z. Qiao, Angew. Chem. Int. Ed., 60, 19572 (2021). M. Shibata, K. Yoshida and N. Furuya, J. Electrochem. Soc., 145, 2348 (1998). M. Shibata and N. Furuya, Electrochim. Acta, 48, 3953 (2003). P. Siva, P. Prabu, M. Selvam, S. Karthik and V. Rajendran, Ionics, 23, 1871 (2017). Y. G. Feng, H. Yang, Y. Zhang, X. Q. Huang, L. G. Li, T. Cheng and Q. Shao, Nano Lett., 20, 8282 (2020). N. N. Meng, Y. M. Huang, Y. Liu, Y. F. Yu and B. Zhang, Cell Reports Physical Science, 2 (2021). N. Cao, Y. L. Quan, A. X. Guan, C. Yang, Y. L. Ji, L. J. Zhang and G. F. Zheng, J. Colloid Interface Sci., 577, 109 (2020).
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Myrhaug, Dag, Hong Wang, and Lars Erik Holmedal. "Discussion/comments of “Parameterization of nearshore wave breaker index” by Chi Zhang, Yuan Li, Yu Cai, Jian Shi, Jinhai Zheng, Feng Cai and Hong Shuai." Coastal Engineering 173 (April 2022): 104042. http://dx.doi.org/10.1016/j.coastaleng.2021.104042.
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Marcella, Benedicta Sophie. "BENTUK DAN MAKNA ATAP KELENTENG SAM POO KONG SEMARANG." Jurnal Arsitektur KOMPOSISI 10, no. 5 (May 1, 2017): 349. http://dx.doi.org/10.24002/jars.v10i5.1094.
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Abstract: Roof might signifiy the lid of upper house or building; objects which are used as a lid of the upper house. The roof of houses or buildings is one of the essential elements or components that make up the traditional architecture. Since ancient times until now, the shape of the roof is a prominent and essential part, showing the different periods. Chinese building roof is the part which has distinctive features. Indonesia also has a plenty of Chinese architectural styles, one of them is Sam Poo Kong Temple in Semarang. This temple was built in 1724 by the Chinese community in Semarang, as a kind of homage to Admiral Zheng He, widely known as Admiral Cheng Ho. In the area of Sam Poo Kong temple, there are several buildings, including the main building (main temple), Goa Pem ujaan, Goa Pemujaan, kelenteng Kyai Juru Mudi, Dewa Bumi, Kyai Nyai Tumpeng dan Kyai Tjundrik Bumi, dan Kyai Jangkar. Roof in Sam Poo Kong Chinese architecture shows the influence of feng shui. The purpose of this study is to find the shapes and the meanings of the roof of the building Sam Poo Kong as well as the influence of the concept of building in China. The method used in this study is qualitative rationalistic. The data was gained from surveys and literature studies. Some related theories are also significantly used to discuss and review the object roof at Sam Poo Kong. The analysis was conducted by comparing the object with the theory. The result of this research is to find the shapes and the meanings of the roof of the building Sam Poo Kong as well as the influence of the concept of Chineses building.Keywords: shapes, meanings, roof of Sam Poo Kong temple , feng shui, chinese architectureAbstrak: Atap memiliki pengertian sebagai penutup rumah atau bangunan sebelah atas; benda yang dipakai untuk penutup rumah sebelah atas. Atap rumah atau bangunan merupakan salah satu unsur atau komponen penting yang membentuk arsitektur tradisional. Sejak jaman dahulu hingga sekarang, bentuk atap adalah bagian yang menonjol ataupun mencolok, menunjukkan periode yang berbeda-beda. Atap bangunan Tiongkok merupakan bagian yang memiliki ciri khas. Indonesia juga memiliki kekayaan langgam arsitektur Tionghoa, salah satunya ada Kelenteng Sam Poo Kong di Semarang. Kelenteng ini dibangun pertama kali pada tahun 1724 oleh masyarakat Tionghoa di Semarang, sebagai bentuk penghormatan kepada Laksamana Zheng He, lebih dikenal dengan nama Laksamana Cheng Ho. Dalam kawasan Kelenteng Sam Poo Kong terdapat beberapa bangunan kelenteng, diantaranya adalah bangunan utama (kelenteng utama), Goa Pemujaan, kelenteng Kyai Juru Mudi, Dewa Bumi, Kyai Nyai Tumpeng dan Kyai Tjundrik Bumi, dan Kyai Jangkar. Atap yang terdapat di Kelenteng Sam Poo Kong menunjukkan arsitektur Tionghoa yang masih mempergunakan kaidah feng shui serta memiliki bentuk dan makna tertentu. Tujuan dari penelitian ini adalah untuk menemukan bentuk dan makna atap bangunan Kelenteng Sam Poo Kong serta pengaruh konsep bangunan di Tiongkok terhadapnya. Metode yang digunakan adalah rasionalistik kualitatif. Data diperoleh dengan survei lapangan dan studi literatur. Teori terkait digunakan untuk membahas dan mengulas obyek atap pada Kelenteng Sam Poo Kong. Analisis dilakukan dengan membandingkan obyek dengan teori. Hasil dari penelitian ini adalah menemukan bentuk dan makna atap bangunan Kelenteng Sam Poo Kong serta pengaruh konsep bangunan di Tiongkok terhadapnyaKata Kunci: bentuk, makna, atap Kelenteng Sam Poo Kong, feng shui, arsitektur Tiongkok
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Křístek, Vladimír, and Jiří Studnička. "Discussion of “ Negative Shear Lag in Cantilever Box Girder with Constant Depth ” by Shih Toh Chang and Feng Zhen Zheng (Jan., 1987, Vol. 113, No. 1)." Journal of Structural Engineering 114, no. 9 (September 1988): 2168–72. http://dx.doi.org/10.1061/(asce)0733-9445(1988)114:9(2168).
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Maisel, B. I. "Discussion of “Negative Shear Lag in Cantilever Box Girder with Constant Depth” by Shih Toh Chang and Feng Zhen Zheng (Jan., 1987, Vol. 113, No. 1)." Journal of Structural Engineering 114, no. 9 (September 1988): 2172–73. http://dx.doi.org/10.1061/(asce)0733-9445(1988)114:9(2172).
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Chang, Shih Toh, and Fang Zhen Zheng. "Closure to “ Negative Shear Lag in Cantilever Box Girder with Constant Depth ” by Shih Toh Chang and Feng Zhen Zheng (Jan., 1987, Vol. 113, No. 1)." Journal of Structural Engineering 114, no. 9 (September 1988): 2173. http://dx.doi.org/10.1061/(asce)0733-9445(1988)114:9(2173).
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Huang, Yuan, Feifei Zheng, Huan-Feng Duan, and Qingzhou Zhang. "Closure to “Skeletonizing Pipes in Series within Urban Water Distribution Systems Using a Transient-Based Method” by Yuan Huang, Feifei Zheng, Huan-Feng Duan, Tuqiao Zhang, Xinlei Guo, and Qingzhou Zhang." Journal of Hydraulic Engineering 146, no. 4 (April 2020): 07020004. http://dx.doi.org/10.1061/(asce)hy.1943-7900.0001727.
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Seog Jung, Bong, and Bryan W. Karney. "Discussion of “Skeletonizing Pipes in Series within Urban Water Distribution Systems Using a Transient-Based Method” by Yuan Huang, Feifei Zheng, Huan-Feng Duan, Tuqiao Zhang, Xinlei Guo, and Qingzhou Zhang." Journal of Hydraulic Engineering 146, no. 4 (April 2020): 07020003. http://dx.doi.org/10.1061/(asce)hy.1943-7900.0001728.
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Zheng, Yu-feng. "Yu-feng Zheng, PHD, Professor and Vice Chair, Department of Materials Science & Engineering, College of Engineering, Peking University, Beijing, China." Endodontic Topics 29, no. 1 (September 2013): 171. http://dx.doi.org/10.1111/etp.12051_12.
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Dai, Wen, Xi Liu, Zhichen Zhang, Jianxin Chen, Rongjuan Guo, Hong Zheng, Xianglan Jin, et al. "A Two-Level Model for the Analysis of Syndrome of Acute Ischemic Stroke: From Diagnostic Model to Molecular Mechanism." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–15. http://dx.doi.org/10.1155/2013/293010.
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Prompt and accurate diagnosis of acute ischemic stroke is critical to seek acute therapy. In traditional Chinese medicine (TCM) science, there is a comprehensive system of diagnosis and medical care of acute ischemic stroke. Here we introduce a two-level model for the analysis of TCM syndrome of acute ischemic stroke. Owing to the limitation of sample size and imbalance, we focused on the analysis of wind-phlegm collateral obstruction syndrome (Feng Tan Yu Zu Zheng). Firstly, a Support-Vector-Machine- (SVM-) based diagnostic model was set up through selection of core symptoms. After pairwise undersampling, we improved the performance of prediction and generated the core symptoms-based diagnostic model of wind-phlegm collateral obstruction syndrome. Next, Pathway Pattern-based method and MetaDrug platform were used to shed light on the molecular basis of the significance of core symptoms in three complementary aspects: symptom-gene-pathway multilayer correlation network, enriched pathways, and most relevant interaction network. The integration of diagnostic model and molecular mechanism analysis creates an interesting perspective for better understanding the syndrome. The two-level model would provide a new opportunity for the study of TCM syndromes.
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Long, Mary Kate, Siyi Liu, and Guangsheng Zhang. "A New Method for Triggering Lithium-Ion Cell Internal Short Circuit (ISC) While Monitoring the ISC Current." ECS Meeting Abstracts MA2022-02, no. 1 (October 9, 2022): 79. http://dx.doi.org/10.1149/ma2022-02179mtgabs.
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Internal short circuit (ISC) is a critical failure mechanism for lithium-ion cells that can lead to disastrous thermal runaway. Therefore, great effort has been made to understand its mechanisms by purposefully triggering ISC through various methods1, 2, such as embedding a nickel particle3 or a wax covered copper pad4 inside lithium-ion cells. While these methods have been successful in triggering ISC, none of them allows measurement of ISC current, a critical parameter that influences heat generation and risk of thermal runaway. Alternatively, Feng et al.5 reported a method of placing a resistor between two parallel-connected cells and using the resistor to externally short circuit the cells. This method could allow measurement of short circuit current, but the resistor is placed between two cells rather than between electrode layers to create different types of ISC6. Inspired by this method5 and the established ISC methods3, 4, here we report a new method that not only triggers lithium-ion cell ISC but also monitors ISC current. As shown schematically in Figure 1, the method works by inserting a pair of small nickel pads inside a lithium-ion cell. One pad is between cathode and separator. The other is between anode and separator. Then the pads are connected electronically outside the cell through insulated metal wires, a switch and a current sensor. Once the switch is closed, the anode and cathode will be shorted at the pad region to form an Anode-Cathode type ISC. The ISC current is forced to flow through the external circuit to be measured by the current sensor. The resistance of the external circuit is much lower than the resistance between nickel pads and their corresponding electrode, so heat generation is focused inside the cell at the pad region as in an ISC scenario. By adjusting dimension of the nickel pads and/or the pressure applied to the pad region, the ISC resistance can be adjusted for investigation of its effects. Furthermore, by connecting one of the pads electronically to the opposite tab, the Anode-Aluminum type ISC and the Cathode-Copper type ISC, can be created. Alternatively, these types of ISC can be created by removing part of electrode coating and placing one of the Ni pads to be in direct contact with current collector. In addition, by embedding thermocouples inside the cell7, temperature distributions can be simultaneously measured for understanding of electrochemically-thermally coupled phenomena during ISC. Figure 2 shows preliminary results obtained from a prototype lithium-ion cell using this new method. The cell has a single unit of electrodes and a nominal capacity of 0.02 Ah. Three types of ISC were created, including Anode-Cathode, Anode-Aluminum and Cathode-Copper. As expected, the Anode-Cathode type ISC had the smallest current while the Anode-Aluminum type ISC had the highest current6, which can be attributed to the high resistance of cathode and the contact resistance between nickel pad and electrode. More results and analysis will be presented. References X. Lai, C. Jin, W. Yi, X. Han, X. Feng, Y. Zheng and M. Ouyang, Energy Storage Materials, 35, 470 (2021). G. Zhang, X. Wei, X. Tang, J. Zhu, S. Chen and H. Dai, Renewable and Sustainable Energy Reviews, 141, 110790 (2021). IEEE, IEEE Std 1625-2008 (Revision of IEEE Std 1625-2004), 1 (2008). E. Darcy and M. Keyser, On-Demand Cell Internal Short Circuit Device, in Power Sources Conference 2014; 9-12 Jun. 2014; , Orlando, FL; United States (2014). X. Feng, X. He, L. Lu and M. Ouyang, Journal of The Electrochemical Society, 165, A155 (2018). S. Santhanagopalan, P. Ramadass and J. Zhang, Journal of Power Sources, 194, 550 (2009). S. Huang, Z. Du, Q. Zhou, K. Snyder, S. Liu and G. Zhang, Journal of The Electrochemical Society, 168, 090510 (2021). Figure 1
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Maruyama, Shigeo. "(Invited) Synthesis and Application of One-Dimensional Van Der Waals Heterostrucures Based on Single-Walled Carbon Nanotubes." ECS Meeting Abstracts MA2022-01, no. 9 (July 7, 2022): 724. http://dx.doi.org/10.1149/ma2022-019724mtgabs.
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A typical one-dimensional (1D) van der Waals (vdW) heterostructure consists of single-walled carbon nanotubes (SWCNT), boron nitride nanotube (BNNT), and molybdenum disulfide nanotube (MoS2NT), can be grown coaxially by successive chemical vapor deposition (CVD) steps [1]. The coaxially nested structure based on SWCNTs can expand the board application possibilities of 1D vdW heterostructures [2]. Semiconductor SWCNT wrapped with BNNT can be regarded as the ideal building blocks of field-effect transistors (FET) [3]. We have demonstrated the radial semiconductor–insulator–semiconductor (S-I-S) tunneling heterojunction diode by using a micrometer long 1D vdW heterostructure SWCNT@BNNT@MoS2NT [4]. By comparing optical properties of films of BNNT@MoS2NT and SWCNT@BNNT@MoS2NT, we found strong photoluminescence (PL) from monolayer MoS2NT and quenching of PL by coupling to SWCNT through thin BNNT [5]. The remarkable population of free charges and inter-tube excitons are demonstrated by ultrafast optical spectroscopy [6]. The inter-tube excition is regarded as the inter-layer excition for 2D heterostructures. Precise control of the chemical vapor deposition (CVD) process of each layer is essential since the mechanical exfoliation & stacking technique for 2D counterpart is not possible for 1D vdW heterostructures. The surprisingly sharp edge of BNNT grown on SWCNT is the signature of preference of nitrogen terminated zig-zag edge of h-BN common to 2D counterpart [7]. The next challenge is the CVD growth of various transition metal dichalcogenides on BNNTs. In addition to MoS2 nanotubes [1], we will discuss the growth control of WS2 nanotubes and NbS2 nanotubes. A general strategy we can tune the CVD condition from 2D flake to 1D tube is proposed [8]. Part of this work was supported by JSPS KAKENHI Grant Number JP20H00220, and by JST, CREST Grant Number JPMJCR20B5, Japan. References [1] R. Xiang, et al., Science, 367 (2020) 537. [2] S. Cambré, et al., Small, 17 (2021) 2102585. [3] R. Xiang, S. Maruyama, Small Sci., 1 (2021) 2000039. [4] Y. Feng, et al., ACS Nano, 15 (2021) 5600. [5] M. Liu, et al., ACS Nano, 15 (2021) 8418. [6] M. G. Burdanova, et al., Adv. Funct. Mater., 9 (2021) 2104969. [7] Y. Zheng, et al, P. Natl. Acad. Sci., 118 (2021) e2107295118. [8] Y. Zheng, et al, to be submitted.
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Feng, Z., M. Cao, L. Duan, and Z. Wu. "THU0211 The Combination of Chinese Herbal Preparation Zheng Qing Feng Tong Ning with Methotrexate for The Treatment of Rheumatoid Arthritis: A Systematic Review and Meta-Analysis." Annals of the Rheumatic Diseases 75, Suppl 2 (June 2016): 264.1–264. http://dx.doi.org/10.1136/annrheumdis-2016-eular.4732.
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ZHANG, Yu-Zhu, Yue ZHOU, Bai-Ling SHI, Hong-Feng CHEN, and Li-Juan CHE. "Effect of the Fu Zheng Method Applied by Hong-Feng CHEN on the Quality of Life in TNBC Patients and Empirical Research Based on Data Mining." Digital Chinese Medicine 1, no. 4 (December 2018): 272–79. http://dx.doi.org/10.1016/s2589-3777(19)30052-7.
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Morgan, Trevor. "Visualizing the discourse in Material Thinking: Conversations between China and South Africa, Chen Qingqing, Feng Jiali, Gu Lin, Liu Liguo, Qi Zhilong, Qing Taimao, Wang Xiaojin and Zhong Biao (China); William Kentridge, Diane Victor, Colbert Mashile, Kristin NG-Yang and Rory Klopper (South Africa), curated by Zhang Siyong." Journal of Arts & Communities 12, no. 1 (June 1, 2021): 119–25. http://dx.doi.org/10.1386/jaac_00026_7.
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Visualizing the discourse in Material Thinking: Conversations between China and South Africa, Chen Qingqing, Feng Jiali, Gu Lin, Liu Liguo, Qi Zhilong, Qing Taimao, Wang Xiaojin and Zhong Biao (China); William Kentridge, Diane Victor, Colbert Mashile, Kristin NG-Yang and Rory Klopper (South Africa), curated by Zhang SiyongDurban Art Gallery, South Africa, 12 September‐10 November 2019
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Ball, Philip. "Synthetic organic chemistry in China: building on an ancient tradition—an interview with Qi-Lin Zhou and Xiaoming Feng." National Science Review 4, no. 3 (April 4, 2017): 437–40. http://dx.doi.org/10.1093/nsr/nwx035.
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Abstract If the core of chemistry is making molecules, then the construction of those found in nature—natural products—has long been regarded as one of the highest forms of the art in synthesis. These molecules, produced by living organisms for a variety of purposes, are a key source of pharmaceuticals such as antibiotics and anticancer agents. The medicinal value of natural products has been known for centuries via herbal treatments, and such compounds are still collected, refined and screened for potential drugs today, sometimes being identified from local ‘folk medicine’ practices. By identifying the active ingredients of natural extracts used in traditional medicine, chemists can then synthesize modified forms that may be even more active: this was how the analgesic aspirin was first identified as a derivative of the plant hormone salicylic acid from willow bark. As well as offering such derivatives, natural-product synthesis in organic chemistry can potentially provide a more plentiful alternative source of natural products that are available in only tiny amounts from their natural sources. Efforts to devise cheap and efficient synthetic strategies for molecules such as paclitaxel (Taxol, an anticancer agent present in the Pacific yew) and artemisinin (an anti-malarial extracted from the herb sweet wormwood, qinghao (青蒿), and recognized by the 2015 Nobel Prize for Medicine) are still on-going to satisfy global demand. Organic synthesis is about much more than making natural products: it contributes, for example, to catalysis, polymer chemistry, food science and the development of wholly synthetic drugs. Yet efforts to make complex natural products may supply a motivational testing ground for developing new synthetic techniques with broader applications. Indeed, many chemists prize the discovery of a new synthetic method above the recreation of some complex natural molecule: it is the means, not the end, that matters. The field of organic and natural-product synthesis has a strong history in China, where there is a long tradition of herbal medicine. The use of the qinghao extract for treating malaria is first recorded in AD 340, in a manual that the 2015 Nobel laureate Tu Youyou says she consulted for clues about isolating the compound in the beginning of 1970s. Some say that, in the past decade, Chinese natural-product chemistry has entered a ‘golden era’ (Zheng Q-Y and Li A. Sci China Chem 2016;59: 1059–60). Qi-Lin Zhou of Nankai University and Xiaoming Feng of Sichuan University have been at the forefront of this upsurge. Both of them have developed methods for making so-called chiral molecules: arrangements of atoms that have a handedness, so that they can exist in two mirror-image versions. Natural products typically are chiral molecules, and their biological activity may depend on having the correct handedness. The selective synthesis of chiral molecules (asymmetric synthesis) is therefore vital to natural-product chemistry, and typically involves the use of catalysts that are chiral themselves. National Science Review spoke to Zhou and Feng about their work and their perspectives on organic synthesis in China. Qi-Lin Zhou of College of Chemistry at Nankai University, China. (Courtesy of Q Zhou)
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Xu, Jie, Fan Song, Baozhen Zhang, Huijue Lyu, Mikoto Kobayashi, Ziyu Zhao, Ye Hou, et al. "Abstract 2953: Subtype-specific and structure variation induced 3D genome alteration in acute myeloid leukemia." Cancer Research 82, no. 12_Supplement (June 15, 2022): 2953. http://dx.doi.org/10.1158/1538-7445.am2022-2953.
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Abstract Acute myeloid leukemia (AML) represents a set of heterogeneous myeloid malignancies hallmarked by mutations in epigenetic modifiers, transcription factors, and kinases that can cause epigenetic reshaping. It is unclear to what extent AML mutations drive chromatin 3D structure alteration and contribute to myeloid transformation. We first performed Hi-C and whole-genome sequencing in 25 AML patient samples and seven healthy donor samples, and identified recurrent alterations of A/B compartments, TADs, and chromatin loops that are unique to different subtypes. To investigate how altered chromatin organization contributes to transcriptional misregulation, we performed RNA-Seq, ATAC-Seq and CUT&ag for CTCF, H3K27ac, and H3K27me3 in the same AML samples. We identified extensive and recurrent AML-specific promoter-enhancer and promoter-repressor loops. We performed both CRISPR deletion and interference experiments and validated two repressor loops that downregulated cancer related genes IKZF2 and RTTN. Furthermore, by using our recently developed algorithm, we identified structural variation-induced enhancer-hijacking and repressor-hijacking events in AML samples. We further demonstrated the role of hijacked enhancers in AML cell growth by CRISPR screening, and the role of hijacked repressors by CRISPR de-repression. We performed whole-genome bisulfite sequencing in 20 AML and normal samples, and showed the delicate relationship between DNA methylation, CTCF binding and 3D genome structure. Finally, by treating the AML cells with the DNA hypomethylating agent and performing triple knockdown of DNMT1/3A/3B, we demonstrated the impact of altered DNA methylation on gene expression and 3D genome organization. Overall this study provides an invaluable resource for leukemia studies and also highlighted the role of repressor-loops and hijacked cis-elements in gene regulation and human diseases. Citation Format: Jie Xu, Fan Song, Baozhen Zhang, Huijue Lyu, Mikoto Kobayashi, Ziyu Zhao, Ye Hou, Xiaotao Wang, Yu Luan, Bei Jia, Lena Stasiak, Qixuan Wang, Qi Jin, Qiushi Jin, Yihao Fu, Ross C. Hardison, Sinisa Dovat, Leonidas C. Platanias, Yue Yang, Tomoko Yamada, Aaron D. Viny, Ross L. Levine, David F. Claxton, James R. Broach, Hong Zheng, Feng Yue. Subtype-specific and structure variation induced 3D genome alteration in acute myeloid leukemia [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2953.
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Zhang, Q. B., Y. Q. Huang, F. N. Xiao, G. L. Jian, Y. P. Tang, F. Dai, J. X. Zheng, and Y. F. Qing. "POS1146 NONCODING RNA CONTRIBUTE TO PATHOGENESIS IN PRIMARY GOUTY ARTHRITIS." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 852.1–852. http://dx.doi.org/10.1136/annrheumdis-2021-eular.4056.
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Background:Gout is an arthritic disease caused by the deposition of monosodium urate crystal (MSU) in the joints, which can lead to acute inflammation and damage adjacent tissue [1].Over the past decade, noncoding RNAs (ncRNAs) have been shown to have crucial importance in health and disease[2,3]. However, studies evaluating the function of ncRNAs in gout are scarce, and current knowledge of the role of ncRNAs in gout is still limited.Objectives:To assess the contribution of noncoding RNAs to gout and the clinical importance of these genes in primary gouty arthritis (GA).Methods:The mRNA expression levels of noncoding RNAs (LINC00173, LINC00963, LINC01330 and miRNA-182-5p) were measured in peripheral blood mononuclear cells (PBMCs) from 60 gout patients(including 30 acute gout patients, 30 intercritical gout patients) and 40 healthy subjects. The relationship between noncoding RNA expression levels and laboratory features was analyzed in GA patients.Results:The expression levels of LINC00173, LINC00963 and miRNA-182-5p were much lower in the AG and IG group than in the HC groups (p<0.05), and no significant difference was detected between AG and IG groups(P>0.05). The expression levels of LINC01330 were much lower in the AG group than in the IG and HC groups (p<0.05), and no significant difference was detected between AG and IG groups(P>0.05). In GA patients, the levels of noncoding RNAs mRNA correlated with laboratory inflammatory and metabolic indexes.Conclusion:Altered noncoding RNAs expression suggests that noncoding RNAs is involved in the pathogenesis of GA and participates in regulating inflammation and metabolism.References:[1]Xu Yi-Ting,Leng Ying-Rong,Liu Ming-Ming et al. MicroRNA and long noncoding RNA involvement in gout and prospects for treatment.[J].Int Immunopharmacol, 2020, 87: 106842.doi:10.1016/j.intimp.2020.106842[2]Yu Yunfang,Zhang Wenda,Li Anlin et al. Association of Long Noncoding RNA Biomarkers With Clinical Immune Subtype and Prediction of Immunotherapy Response in Patients With Cancer.[J].JAMA Netw Open, 2020, 3: e202149.doi:10.1001/jamanetworkopen.2020.2149[3]Zou Yaoyao,Xu Siqi,Xiao Youjun et al. Long noncoding RNA LERFS negatively regulates rheumatoid synovial aggression and proliferation.[J].J Clin Invest, 2018, 128: 4510-4524.doi:10.1172/JCI97965Figure 1.Relative Expression of noncoding RNAs in the PBMCs of Patients.Disclosure of Interests:Quan-Bo Zhang Grant/research support from: the National Natural Science Foundation of China(General Program) (no.81974250) and Science and Technology Plan Project of Sichuan Province (no.2018JY0257), Yu-Qin Huang: None declared, Fan-Ni Xiao: None declared, gui-lin jian: None declared, Yi-Ping Tang: None declared, Fei Dai: None declared, Jian-Xiong Zheng: None declared, Yu-Feng Qing Grant/research support from: Science and Technology Project of Nanchong City (no.18SXHZ0522).
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Zheng, Shansong, Wei Deng, Qingmei Zheng, Yingying Yang, Na Li, Tan Pang, Xueying Feng, et al. "Abstract 5457: QLH11811, a selective 4th-generation EGFR inhibitor for osimertinib-resistant EGFR-mutant NSCLC." Cancer Research 82, no. 12_Supplement (June 15, 2022): 5457. http://dx.doi.org/10.1158/1538-7445.am2022-5457.
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Abstract Background: The 3rd-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI), like osimertinib, provide marked clinical benefit for EGFR-mutant non-small cell lung cancer (NSCLC) patients with extended overall survival vs former EGFR TKIs (e.g., gefitinib). Approximate 10%-24% of NSCLC patients acquired C797S mutation when treated with osimertinib. Unfortunately, limited treatments are available for patients after osimertinib resistance. QLH11811 is a new generation EGFR TKI designed to target the EGFR with ex19del/L858R/T790M/C797S mutations. Here, we disclosed its preclinical data to support its clinical development in EGFR-mutant NSCLC. Methods: The inhibitory activity of QLH11811 on mutated and wild-type EGFR was tested in engineered cell lines and patient-derived organoid (PDO). The in vivo antitumor activity of QLH11811 was evaluated in the patient-derived xenograft (PDX) model with cis EGFR ex19del/T790M/C797S triple mutations, and the H1975 (cis EGFR L858R/T790M/C797S and cis EGFR ex19del/T790M/C797S), PC-9 (EGFR ex19del), and Ba/F3 (EGFR ex19del/C797S) cell line-derived xenograft (CDX) models. The pharmacokinetic (PK) profile was investigated in animals, and the human PK profile was projected using allometric scaling method. Results: QLH11811 displayed potent anti-proliferation activity against Ba/F3 (EGFR ex19del/T790M/C797S, L858R/T790M/C797S, ex19del/C797S, or L858R/C797S), PC-9 (EGFR ex19del/T790M/C797S), H1975 (EGFR L858R/T790M/C797S, L858R/T790M), H3255 (L858R) and HCC827 (ex19del) with IC50 of 2.6, 3.1, 2.4, 4.1, 51, 50, 27, 21, and 11 nM, respectively. QLH11811 also showed excellent selectivity when compared the above values with its IC50 against Ba/F3 (EGFR wild-type, 61 nM) and A431 (EGFR wild-type, 440nM). QLH11811 demonstrated excellent inhibitory activities against seven osimertinib-resistant PDO models. Daily oral QLH11811 significantly inhibited tumor growth at all doses tested (P <0.001) in the PDX model, the H1975, PC-9, and Ba/F3 CDX models. QLH11811 had good PK profile in mice, rats, dogs, and monkeys, with the absolute bioavailability at 71%, 29%, 80% and 42%. The human PK parameters were obtained by allometric scaling method, and the efficacious dose in human was projected to 103 mg, daily. Conclusion: The in vitro and in vivo preclinical data demonstrated QLH11811 is a highly potent and selective 4th-generation EGFR TKI with activity against the osimertinib-resistant NSCLC with EGFR C797S mutation. The preclinical PK data supported the efficacious dose of QLH11811 in human would be 103 mg. Citation Format: Shansong Zheng, Wei Deng, Qingmei Zheng, Yingying Yang, Na Li, Tan Pang, Xueying Feng, Simon Taylor, Lina Ma, Yaqiong Wu, Ziwei Zhao. QLH11811, a selective 4th-generation EGFR inhibitor for osimertinib-resistant EGFR-mutant NSCLC [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5457.
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Zheng, Ze-yi, Hanan Elsarraj, Yang Hong, Jonathan T. Lei, Meenakshi Anurag, Yichao Shen, Flora Lo, et al. "Abstract 2979: ElevatedNRASexpression as a potential driver of DCIS progression to basal-like invasive breast cancer." Cancer Research 82, no. 12_Supplement (June 15, 2022): 2979. http://dx.doi.org/10.1158/1538-7445.am2022-2979.
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Abstract Background: Ductal carcinoma in situ (DCIS) is the most common type of in situ premalignant breast cancers. What drives a subset of luminal DCIS to transition to basal invasive breast cancers is unclear. Basal-like invasive breast cancers are aggressive and associated with the shortest overall survival and time to distant metastasis. We have previously shown that N-Ras is highly expressed selectively in the basal-like subtypes of invasive breast cancers and can promote their growth and progression. In this study, we investigated whether NRAS expression at the DCIS stage can control transition from luminal DCIS to basal-like invasive breast cancers. Methods: Wilcoxon rank-sum test was conducted to assess the relative expression of NRAS in DCIS compared to invasive breast cancers in a patient cohort (GSE59248). NRAS levels were also determined by fluorescence in situ hybridization (FISH) in a collection of 21 patient tumor microarrays (TMAs) with concurrent normal, DCIS, and invasive breast cancer, and NRAS’s association with DCIS and invasive breast cancer was assessed by Wilcoxon signed rank test. How NRAS levels correlated with basal biomarkers in the TMAs, as well as in patient datasets GSE59248 and GSE3369 was determined by Pearson correlation. Gene expression changes in cell line were assessed by RNA-seq. Results: Invasive breast cancers showed higher NRAS mRNA levels, as compared to DCIS samples. These NRAShigh lesions were also enriched with basal-like features, such as basal gene expression signature, lower ER, higher p53 protein levels, and higher Ki67 levels. We have shown previously that N-Ras is a driver for tumor growth in SUM102 cells, which is a DCIS-like cell line model displaying basal-like features. Here we found that NRAS-silencing in these cells induced a shift to a luminal gene expression pattern as determined by PAM50. Conclusions: These data suggest that the rise of N-RAS levels in DCIS can not only mark but also control the emergence of basal-like features leading to more aggressive tumor activities. Targeting N-Ras and/or its downstream pathway may prevent the emergence of basal invasive breast cancers. Citation Format: Ze-yi Zheng, Hanan Elsarraj, Yang Hong, Jonathan T. Lei, Meenakshi Anurag, Yichao Shen, Flora Lo, Long Feng, Zifan Zhao, Xiang H. Zhang, Fariba Behbod, Eric C. Chang. ElevatedNRASexpression as a potential driver of DCIS progression to basal-like invasive breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2979.
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Feng, Shechao, Leonardo Golubović, and Yi-Cheng Zhang. "Feng, Golubović, and Zhang reply." Physical Review Letters 66, no. 16 (April 22, 1991): 2177. http://dx.doi.org/10.1103/physrevlett.66.2177.
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Whittingham, Stan, BEN PEI, Isik Buyuker, Krystal Lee, Fengxia Xin, and Hui Zhou. "(Invited, Digital Presentation) Pushing the Limits of High Nickel NMC Cathodes." ECS Meeting Abstracts MA2022-01, no. 2 (July 7, 2022): 334. http://dx.doi.org/10.1149/ma2022-012334mtgabs.
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Lithium-ion batteries now dominate electrochemical energy storage for vehicle propulsion and grid storage in addition to portable electronics. In 2022, they celebrate their 50th anniversary, and yet still achieve only 25% of their theoretical energy density. The dominant anode and cathode today are graphitic carbon and the layered NMC oxides, LI[NiMnCoAl]O2. Both need improving. Most of the carbon in the anode must go, and the NMCs need pushing to their limit and at the same time eliminating cobalt. I will today discuss the challenges faced as we push the limits of the NMCs to their limits, > 80% lithium cycling, and Ni>0.8 and Co <<0.1. The higher the Ni content the lower the charging voltage needed for a given cycling capacity, but the greater its surface and bulk reactivity. The issues discussed will include 1stcycle loss [1], high rate capability [2], cathode stability [3], and surface/bulk reactivity and the impact of surface/bulk modification [4,5] and the micron-size single crystals vs meatballs on these [6]. This work is being supported by DOE-EERE-BMR-Battery500 consortium. [1]. Hui Zhou, Fengxia Xin, Ben Pei, M. Stanley Whittingham, “What Limits the Capacity of Layered Oxide Cathodes in Lithium Batteries?”, ACS Energy Lett. 2019, 4: 1902−1906. [2]. Chunmei Ban, Zheng Li, Zhuangchun Wu, Melanie J. Kirkham, Le Chen, Yoon Seok Jung, E. Andrew Payzant, Yanfa Yan, M. Stanley Whittingham, and Anne C. Dillon “Extremely Durable High-Rate Capability of a LiNi0.4Mn0.4Co0.2O2 Cathode Enabled by Single–Wall Carbon Nanotubes”, Advanced Energy Materials, 2011, 1: 58-62. [3]. Hyung-Joo Noh, Sungjune Youn, Chong Seung Yoon, Yang-Kook Sun “Comparison of the structural and electrochemical properties of layered Li[NixCoyMnz]O2 (x = ¼ 1/3, 0.5, 0.6, 0.7, 0.8 and 0.85) cathode material for lithium-ion batteries”, J. Power Sources, 2013, 233: 121-130. [4]. Fengxia Xin, Hui Zhou, Yanxu Zong, Mateusz Zuba, Yan Chen, Natasha A. Chernova, Jianming Bai, Ben Pei, Anshika Goel, Jatinkumar Rana, Feng Wang, Ke An, Louis F. J. Piper, Guangwen Zhou, and M. Stanley Whittingham, “What is the Role of Nb in Nickel-Rich Layered Oxide Cathodes for Lithium-Ion Batteries?”, ACS Energy Letters, 2021, 6: 1377-1382. [5]. Ben Pei, Hui Zhou, Anshika Goel, Mateusz Zuba, Hao Liu, Fengxia Xin, and M. Stanley Whittingham, “Al Substitution for Mn during Co-Precipitation Boosts the Electrochemical Performance of LiNi0.8Mn0.1Co0.1O2”, J. Electrochemical Society, 2021, 68: 050532. [6]. Yujing Bi, Jinhui Tao, Yuqin Wu, Linze Li, Yaobin Xu, Enyuan Hu, Bingbin Wu, Jiangtao Hu, Chongmin Wang, JiGuang Zhang, Yue Qi and Jie Xiao, “Reversible planar gliding and microcracking in a single-crystalline Ni-rich cathode”, Science, 2020, 370: 1313-1317.
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Palleschi, Vincenzo. "Comment on “A multivariate model based on dominant factor for laser-induced breakdown spectroscopy measurements” by Zhe Wang, Jie Feng, Lizhi Li, Weidou Ni and Zheng Li, J. Anal. At. Spectrom., 2011, DOI: 10.1039/c1ja10041f." Journal of Analytical Atomic Spectrometry 26, no. 11 (2011): 2300. http://dx.doi.org/10.1039/c1ja10197h.
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Huang, Y. Q., Q. B. Zhang, J. X. Zheng, G. L. Jian, T. H. Liu, X. He, F. N. Xiao, Q. Xiong, and Y. F. Qing. "POS0136 ROLES OF AUTOPHAGY IN THE PATHOGENESIS OF PRIMARY GOUTY ARTHRITIS." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 280.1–280. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3592.
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Background:Gout is a chronic autoinflammatory disease caused by monosodium urate (MSU) crystal deposition [1].Acute gout is characterized by an acute inflammatory reaction that resolves spontaneously within a few days[2], which is one of the distinguishing features of gout compared to other arthropathies or self-inflammatory diseases. Autophagy is a lysosomal degradation pathway that is essential for cellular growth, survival, differentiation, development and homeostasis [3]. Studies have demonstrated that autophagy might play a key role in the pathogenesis of primary gouty arthritis (GA) [4-7]. However, the roles of autophagy in the development of gout have not yet been elucidated.Objectives:The aim of our study was to investigate the changes in autophagy-related gene (ATG) mRNA and protein in patients and the clinical importance of these genes in primary gouty arthritis (GA) and to explore the roles of autophagy in the pathogenesis of GA.Methods:The mRNA and protein expression levels of ATGs (ATG3, ATG7, ATG10, ATG5, ATG12, ATG16L1, ATG4B and LC3-2) were measured in peripheral blood mononuclear cells (PBMCs) from 196 subjects, including 57 acute gout patients (AG group), 57 intercritical gout patients (IG group) and 82 healthy control subjects (HC group). The relationship between ATG expression levels and laboratory features was analyzed in GA patients.Results:The expression levels of ATG4B, ATG5, ATG12, ATG16L1, ATG10 and LC3-2 mRNA were much lower in the AG group than in the IG and HC groups (p<0.05), while the ATG7 mRNA level was much higher in the AG group than in the IG and HC groups (p<0.05). The protein expression levels of LC3-2, ATG3, ATG7 and ATG10 were much higher in the AG group than in the other groups, while those of ATG5, ATG12, ATG16L1 and ATG4B were far lower in the AG group than in the other groups (p<0.05). In GA patients, the levels of ATG mRNA and protein correlated with laboratory inflammatory and metabolic indexes.Conclusion:Altered ATG expression suggests that autophagy is involved in the pathogenesis of GA and participates in regulating inflammation and metabolism.References:[1]Dalbeth N, Choi HK, Joosten LAB, Khanna PP, Matsuo H, Perez-Ruiz F, et al. Gout. Nat Rev Dis Primers. 2019;5: 69.doi:10.1038/s41572-019-0115-y.[2]Schauer C, Janko C, Munoz LE, Zhao Y, Kienhöfer D, Frey B, et al. Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines. Nat Med. 2014;20: 511-517.doi:10.1038/nm.3547.[3]Han Y, Zhang L, Xing Y, Zhang L, Chen X, Tang P, et al. Autophagy relieves the function inhibition and apoptosis-promoting effects on osteoblast induced by glucocorticoid. Int J Mol Med. 2018;41: 800-808. doi:10.3892/ijmm.2017.3270.[4]Yang QB, He YL, Zhong XW, Xie WG, Zhou JG. Resveratrol ameliorates gouty inflammation via upregulation of sirtuin 1 to promote autophagy in gout patients. Inflammopharmacology. 2019;27: 47-56.doi:10.1007/s10787-018-00555-4.[5]Mitroulis I, Kambas K, Chrysanthopoulou A, Skendros P, Apostolidou E, Kourtzelis I, et al. Neutrophil extracellular trap formation is associated with IL-1β and autophagy-related signaling in gout. PLoS One. 2011;6: e29318.doi: 10.1371/journal.pone.0029318.[6]Crişan TO, Cleophas MCP, Novakovic B, Erler K, van de Veerdonk FL, Stunnenberg HG, et al. Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway. Proc Natl Acad Sci U S A. 2017;114: 5485-5490.doi:10.1073/pnas.1620910114.[7]Lee SS, Lee SW, Oh DH, Kim HS, Chae SC, Kim SK. Genetic analysis for rs2241880(T > C) in ATG16L1 polymorphism for the susceptibility of Gout. J Clin Rheumatol. 2019;25: e113-e115.doi:10.1097/rhu.0000000000000685.Disclosure of Interests:Yu-Qin Huang: None declared, Quan-Bo Zhang Grant/research support from: National Natural Science Foundation of China(General Program) (no.81974250) and Science and Technology Plan Project of Sichuan Province (no.2018JY0257), Jian-Xiong Zheng: None declared, gui-lin jian: None declared, tao-hong liu: None declared, Xin He: None declared, fan-ni xiao: None declared, qin xiong: None declared, Yu-Feng Qing Grant/research support from: Science and Technology Project of Nanchong City (no.18SXHZ0522)
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Liu, Yongshang, Sung-Hwan Kim, and Xinyu Li. "The Effects of ESG Performance on Export Intensity of Korean Firms." Korea International Trade Research Institute 18, no. 6 (December 31, 2022): 1–18. http://dx.doi.org/10.16980/jitc.18.6.202212.1.
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Purpose – This study examines whether the export intensity of firms listed in the Korean market is affected by environmental, social and governance (ESG) ratings. We test whether the environmental, social, and governance (ESG) performance in ratings of Korean firms can improve their export intensity in the global markets. Design/Methodology/Approach – In this study, we introduce ESG ratings, export intensity and other control variables in the models using unbalanced panel data of 1,974 firms listed on the KOSPI and KOSDAQ Exchange between 2012 and 2021 from a merged dataset of the KIS-VALUE and TS-2000 databases. We apply the fixed effects model (FEMs) after applying the Hausman and Lagrangian multiplier tests. Also, we apply instrument variable regressions (IV regressions) to control endogeneity in ESG ratings affected by other factors introduced. Findings – First, higher ESG ratings of the firms have a significantly negative effect on export intensity, which is inconsistent with the results of the previous research (Herding and Poncet, 2014). Second, ESG ratings of chaebol firms do not significantly reduce export intensity. The results might be due to the less severe constraints in chaebol firms by ESG costs. (Chaney, 2008; Shi Xin-Zheng and Xu Zhu-Feng, 2018). Third, each ESG rating, E, S, and G individually, shows a significantly negative effect on export intensity for only non-chaebol firms, while such an effect for chaebol firms is not statistically significant. Fourth, using the instrument variable regression, we have verified the result that ESG performance has a negative effect on firms' export intensity. Research Implications – This study is the first to examine the relationship between the ESG ratings of Korean firms and their export intensity, whose result is different from that of a prior study regarding Chinese firms (Wu Qing-Lan, Chen Gui-Fu, Han Jing and Wu Li-Yan, 2022). The negative effects of ESG ratings in Korea on exports for non-chaebol firms suggest that higher ESG ratings of Korean firms are not favorably accepted by their counterparts in the global markets while their efforts to get or enhance higher ratings incurring more expenses might hurt their competence in the global markets. Such negative effects of ESG ratings are not clearly observed for chaebol affiliated firms.
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Liu, Siyi, Shan Huang, Qian Zhou, Kent Snyder, Mary Kate Long, and Guangsheng Zhang. "Understanding Li-Ion Cell Internal Short Circuit during Nail Penetration By Simultaneous in Situ Measurement of Local Current, Resistance and Temperature." ECS Meeting Abstracts MA2022-02, no. 3 (October 9, 2022): 356. http://dx.doi.org/10.1149/ma2022-023356mtgabs.
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Internal short circuit (ISC) can be a main cause of Li-ion cell thermal runaway in field failures, but its mechanisms still require better understanding1 , 2. Due to the highly localized and electrochemical-thermal coupled nature of ISC, it is important to use in situ/operando measurement of critical parameters for insightful understanding of the mechanisms. We recently reported a method for in situ measurement of dynamic ISC resistance and ISC current during nail penetration as schematically shown in Figure 1(a)3. When an ISC is formed inside the small test cell by nail penetration, external current will flow from the large power supply cell to the test cell. The test cell capacity is much smaller than the large power supply cell, so the measured current (A) can be assumed to be equal to the ISC current. The ISC voltage (V) is measured directly. Then the ISC resistance can be obtained through dividing the ISC voltage by the ISC current. The local temperature at the ISC spot is directly measured by a thermocouple embedded at the tip of the smart nail4. The previous method enabled insightful understanding of ISC3. It was observed that the ISC resistance changed by several orders of magnitude during nail penetration and dramatically influenced heat generation and local temperature rise. In some cases, the local ISC temperature increased more than 500 ℃, and even caused melting of Al foil in contact with the nail and rapid recovery of ISC resistance. But the previous method has a shortcoming. As noted in Figure 1(a), the small test cell with ISC is chemically and thermally disconnected from the large power supply cell. Such disconnection makes the thermal behaviors of the cells different from a real-world large Li-ion cell in which the ISC location is electrochemically and thermally connected to the entire cell. In particular, it does not allow investigation of thermal runaway propagation from the ISC location to the large cell. Built on our previous work while addressing its shortcoming, here we report an improved method. As shown schematically in Figure 1(b), a small cell and a large cell are fabricated inside the same pouch, sharing the same electrolyte and the same separator. They are not only electrically connected, but also chemically and thermally connected. The measurement of ISC current, resistance and temperature is similar to our previous work. When the smart nail penetrates the small cell, the ISC current flows from the large cell to the small cell through the external wire and can be measured by a current sensor (A). The ISC resistance is obtained from directly measured ISC current and ISC voltage. The local temperature can be measured not only by the thermocouple embedded at the tip of the smart nail, but also by thermocouples embedded at different locations inside the large cell5. This new method will enable insightful understanding of the highly localized and electrochemical-thermal coupled ISC phenomena under conditions closer to field failures. The experimental data can also be used for validation and improvement of numerical models of ISC. References X. Lai, C. Jin, W. Yi, X. Han, X. Feng, Y. Zheng and M. Ouyang, Energy Storage Materials, 35, 470 (2021). G. Zhang, X. Wei, X. Tang, J. Zhu, S. Chen and H. Dai, Renewable and Sustainable Energy Reviews, 141 (2021). S. Liu, S. Huang, Q. Zhou, K. Snyder, M. Long and G. Zhang, 241st ECS Meeting, May 29- June 2, 2022, Vancouver, BC, Canada (2022). S. Huang, X. Du, M. Richter, J. Ford, G. M. Cavalheiro, Z. Du, R. T. White and G. Zhang, Journal of The Electrochemical Society, 167 (2020). S. Huang, Z. Du, Q. Zhou, K. Snyder, S. Liu and G. Zhang, Journal of The Electrochemical Society, 168 (2021). Figure 1
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Wang, Xiaoping, Magali Ferrandon, Jaehyung Park, Evan C. Wegener, A. Jeremy Kropf, and Deborah J. Myers. "Optimization of Synthesis Variables Towards Improved Activity and Stability of Fe-N-C PGM-Free Catalysts." ECS Meeting Abstracts MA2022-01, no. 35 (July 7, 2022): 1447. http://dx.doi.org/10.1149/ma2022-01351447mtgabs.
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Materials in the Fe-N-C family are the most promising platinum group metal-free (PGM-free) catalysts for the oxygen reduction reaction (ORR) in polymer electrolyte fuel cells (PEFCs).1-3 Although significant progress has been made in recent years in improving both the ORR activity and durability of the Fe-N-C catalysts, further improvements are needed, especially in long-term performance durability in hydrogen-air PEFCs, to enable their use in applications such as propulsion power for light-duty vehicles.3 The most active ORR catalysts in the Fe-N-C family were synthesized by heat treating iron salts or other iron-containing compounds with zinc-based zeolitic imidazolate frameworks (ZIFs) and/or phenanthroline (as carbon and nitrogen sources), or by heat treating iron-substituted ZIFs. For this family of PGM-free materials, it has been shown that many synthesis variables, such as the metal and carbon-nitrogen macrocycle content, the heat treatment temperature, atmosphere, and temperature profile all affect the activity and durability of the resulting catalysts.4-7 Optimization of these variables and testing the resulting catalyst properties is not a trivial task, and only a limited portion of the composite composition and temperature space has been explored for this family of catalysts. To accelerate optimization of the synthesis variables to obtain improved ORR activity and stability for the Fe-N-C catalysts, high-throughput synthesis and characterization methods were developed and utilized. An automation platform, a multi-port ball-mill, and parallel fixed bed reactors in Argonne’s High-throughput Research Laboratory were used to rapidly synthesize the PGM-free catalysts with systematically-varied synthesis conditions. A multi-channel flow double electrode (m-CFDE) cell and other cells were designed and constructed for the simultaneous testing the ORR activity and stability of the multiple catalysts synthesized. The ORR activity and stability of the catalysts were correlated with their Fe speciation, as determined using Fe K-edge X-ray absorption spectroscopy (XAFS), electrochemically-determined surface areas, and other variables, which is beneficial for the further improved catalyst activity and stability. References B. Pivovar, Nature Catalysis, 2 (2019) 562. S. Thompson and D. Papageorgopoulos, Nature Catalysis, 2 (2019) 558. L. Osmieri, J. Park, D.A. Cullen, P. Zelenay, D.J. Myers, and K.C. Neyerlin, Curr. Opin. Electrochem., 25 (2021) 100627. X. Wang, H. Zhang, H. Lin, S. Gupta, C. Wang, Z. Tao, H. Fu, T. Wang, J. Zheng, G. Wu, and X. Li, Nano Energy, 25 (2016) 110. H. Zhang, S. Hwang, M. Wang, Z. Feng, S. Karakalos, L. Luo, Z. Qiao, X. Xie, C. Wang, D. Su, Y. Shao, and G. Wu, J. Am. Chem. Soc., 139 (2017) 14143-14149. E. Proietti, F. Jaouen, M. Lefevre, N. Larouche, J. Tian, J. Herranz, and J.-P. Dodelet, Nature Comm. 2 (2011) 1. A. Zitolo, V. Goellner, V. Armel, M.-T. Sougrati, T. Mineva, L. Stievano, E. Fonda, and F. Jaouen, Nature Materials, 14 (2015) 937. This work was supported by the U.S. Department of Energy (DOE), Energy Efficiency and Renewable Energy, Hydrogen and Fuel Cell Technologies Office (HFTO) under the auspices of the Electrocatalysis Consortium (ElectroCat). This work utilized the resources of the Advanced Photon Source, a U.S. DOE Office of Science user facility operated by Argonne National Laboratory for DOE Office and was authored by Argonne, a U.S. Department of Energy (DOE) Office of Science laboratory operated for DOE by UChicago Argonne, LLC under contract no. DE-AC02-06CH11357.
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Tang, Y. P., Y. F. Qing, Z. R. Dong, F. Dai, J. Zheng, Y. Jiang, Y. X. He, and Q. B. Zhang. "AB0075 HSA_CIRC_0012732, HSA_CIRC_0008961, HSA_CIRC_0405239 AND HSA_CIRC_0068784 MIGHT BE INVOLVED IN THE PATHOGENESIS AND DEVELOPMENT OF ANKYLOSING SPONDYLITIS." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 1067.3–1068. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3412.
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Background:CircRNAs have been found to be involved in the occurrence and development of many rheumatic diseases[1-2]. Are circRNAs involved in the pathogenesis of ankylosing spondylitis (AS)? How do these circRNAs participate in the pathogenesis of AS? This all needs further study.Objectives:This study is to clarify the expression levels of hsa_circ_0012732, hsa_circ_0008961, hsa_circ_0405239 and hsa_circ_0068784 in the peripheral blood of AS patients, and to explore whether these circRNAs are involved in the pathogenesis of AS.Methods:To collected 60 cases of AS (30 cases of active AS (ASA): BASDA> 6 or 6> BASDAI> 4, ESR> 22mm / h or 6> BASDAI> 4, hsCRP> 9mg / L; 30 cases of stable AS (ASS): BASDAI <4) and 30 health control (HC) peripheral blood samples, related clinical and laboratory indicators. The relative expression levels of hsa_circ_0012732, hsa_circ_0008961, hsa_circ_0405239 and hsa_circ_0068784 in each group were detected by real-time quantitative polymerase chain reaction (qPCR). The relationships between the 4 circRNAs and clinical and laboratory indicators were explored by correlation analysis.Results:1. The qPCR results suggested that the expression of hsa_circ_0012732 between the ASA and ASS groups was statistically significant (p<0.05), and the expression of hsa_circ_0008961 was statistically significant between the ASA and HC groups (p<0.05). Howeverthere was no statistical significance among other groups (p>0.05)Figure 1. Similarly, the expression level of hsa_circ_0405239 was not statistically significant among the groups (p>0.05), and the same was true for hsa_circ_0068784 (p>0.05).2. Correlation analysis results (Figure 2) showed that hsa_circ_0012732 is positively correlated with lymphocyte count (LY), mean corpusular volume (MCV), albumin (ALB), and negatively correlated with Bath ankylosing spondylitis disease activity index (BASDAI), Bath ankylosing spondylitis functional index (BASFI), high sensitivity C-reactive protein (hsCRP), Globulin (GLOB) (p<0.05); hsa_circ_0008961 is negatively correlated with platelet (PLT) (p<0.05); hsa_circ_0405239 is negatively correlated with BASDAI and BASFI; hsa_circ_0068784 was negatively correlated with BASDAI (p<0.05); and there was no statistically significant (p>0.05) between these 4 circRNAs and other indicators.Conclusion:Hsa_circ_0012732, hsa_circ_0008961, hsa_circ_0405239 and hsa_circ_0068784 may be related to the pathogenesis of AS. Among them, hsa_circ_0012732 may be involved in AS inflammation and has the potential to participate in the judgment of disease activity.References:[1]LS, K., et al., The biogenesis, biology and characterization of circular RNAs. 2019. 20(11): p. 675-691.[2]J, W., et al., Non-coding RNAs in Rheumatoid Arthritis: From Bench to Bedside. 2019. 10: p. 3129.Disclosure of Interests:Yi-Ping Tang Grant/research support from: Science and Technology Project of Nanchong City (18SXHZ0522)., Yu-Feng Qing: None declared, Zeng-Rong Dong: None declared, Fei Dai: None declared, Jianxiong Zheng: None declared, Yi Jiang: None declared, Yi-Xi He: None declared, Quan-Bo Zhang Grant/research support from: National Natural Science Foundation of China(General Program) (81974250); Science and Technology Plan Project of Sichuan Province (2018JY0257)
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Qing, Y. F., F. Dai, Q. B. Zhang, Y. P. Tang, Z. R. Dong, Y. X. He, Y. Jiang, Y. Q. Huang, and J. Zheng. "AB0011 EXPRESSION PROFILE AND POTENTIAL FUNCTION OF CIRCRNAS IN PERIPHERAL BLOOD MONONUCLEAR CELLS FROM PATIENTS WITH PRIMARY GOUT." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 1040.2–1040. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3081.
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Background:Autophagy is a phenomenon of “self-phagocytosis” in eukaryotic cells, which maintains cell homeostasis by transporting intracellular materials to lysosomes for degradation and recycling. In recent years, studies have shown that autophagy may be involved in the pathogenesis of rheumatoid arthritis(RA)[1], but its specific mechanism is still unclear.Objectives:The expression levels of autophagy-related genes(ATG) unc-51-like kinase 1(ULK1), ATG13, ATG17, microtubule associated protein 1 light chain 3 (LC3), and P62 in peripheral blood mononuclear cells (PBMC) of patients with RA were detected, and their role and clinical significance in the pathogenesis of RA were explored.Methods:Real-time fluorescent quantitative PCR was performed to detect the expression levels of ULK1, ATG13, ATG17, LC3, and P62 in PBMCs of 50 RA patients, 50 healthy controls (HC), and 25 moderate to severe RA patients before and after treatment. Then, t test, χ2 test, Mann-Whitney U test, Pearson test were used for statistical analysis.Results:1.The levels of hsCRP, white blood cell(WBC), neutrophils(GR), platelet(PLT) and plateletcrit(PCT) in RA group were higher than those in HC group (P <0.05). Lymphocytes (LY), red blood cell(RBC), hemoglobin(HGB), hematocrit(HCT), mean corpuscular hemoglobin(MCH), mean red blood cell volume(MCV) and mean red blood cell hemoglobin concentration(MCHC) in RA group were lower than those in HC group (P <0.05). 2.The expressions of ULK1, ATG17, and LC3 in RA group were higher than those in HC group, while the expressions of P62 was lower than those in HC group(P<0.05) (Figure 1). The correlation analysis suggested that ATG17 was positively correlated with tender joint count (TJC), swollen joint count (SJC), and health assessment questionnaire (HAQ) (P<0.05); ULK1 and HAQ were negatively correlated (P<0.05).3. Compared with before treatment with TNFi, ATG17, HAQ, DAS-28, ESR, hsCRP, WBC, GR, PLT and PCT were significantly reduced after treatment (P<0.05); the expressions of RBC, HCT, MCV and MCH were significantly increased after treatment,(P<0.05); ULK1, ATG13, LC3, P62 and other related clinical and laboratory indicators were not significantly different before and after treatment with TNFi (P>0.05).Figure 1.The expression levels of ATGs in HC and RA groups.Conclusion:There is abnormal expression of autophagy genes in the peripheral blood of RA patients. ULK1, ATG17, LC3 and P62 may be related to the pathogenesis of RA, among them, ATG17 may regulate the pathogenesis of RA by participating in the TNF-α pathway.References:[1]Rockel Jason S,Kapoor Mohit,Autophagy: controlling cell fate in rheumatic diseases.[J].Nat Rev Rheumatol, 2016, 12: 517-31.Disclosure of Interests:Yu-Feng Qing Grant/research support from: Science and Technology Project of Nanchong City (no.18SXHZ0522), Fei Dai: None declared, Quan-Bo Zhang Grant/research support from: the National Natural Science Foundation of China(General Program) (no.81974250), and Science and Technology Plan Project of Sichuan Province (no.2018JY0257), Yi-Ping Tang: None declared, Zeng-Rong Dong: None declared, Yi-Xi He: None declared, Yi Jiang: None declared, Yu-Qin Huang: None declared, Jianxiong Zheng: None declared
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Zhou, Hua-rong, Jian-zhen Shen, Hai-ying Fu, and Feng Zhang. "Erratum to: Genistein-induced Anticancer Effects on Acute Leukemia Cells Involve the Regulation of Wnt Signaling Pathway Through H4K20me1 Rather Than DNA Demethylation." Current Medical Science 41, no. 6 (December 2021): 1257. http://dx.doi.org/10.1007/s11596-021-2478-z.
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The article “Genistein-induced Anticancer Effects on Acute Leukemia Cells Involve the Regulation of Wnt Signaling Pathway Through H4K20me1 Rather Than DNA Demethylation”, written by Hua-rong ZHOU, Jian-zhen SHEN, Hai-ying FU, Feng ZHANG was originally published electronically on the publisher’s internet portal on October 2021 without open access. With the author(s)’ decision to opt for Open Choice, the copyright of the article is changed to © The Author(s) 2021 and the article is forthwith distributed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The original article has been corrected.
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Wang, Pu. "Poets of the Chinese Revolution Chen Duxiu, Chen Yi, Mao Zedong and Zheng Chaolin Edited by Gregor Benton and Feng Chongyi, translated by Gregor Benton London and New York: Verso, 2019 xix + 291 pp. £29.95; $39.99 ISBN 978-1-78873-468-4." China Quarterly 240 (November 4, 2019): 1173–75. http://dx.doi.org/10.1017/s0305741019001346.
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Feng, Zheng, Danyi Wang, Francesco Vallania, Neil Smith, Anupriya Tripathi, and Juergen Scheuenpflug. "Abstract 5113: Liquid biopsy-based multiomics profiling using low-pass whole genome sequencing and proteomics with computational modeling reveals molecular correlates of disease severity in EGFR/ALK wild type NSCLC patients." Cancer Research 82, no. 12_Supplement (June 15, 2022): 5113. http://dx.doi.org/10.1158/1538-7445.am2022-5113.
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Abstract Background: Molecular features of disease severity provide a basis for patient stratification, and may hint at previously unrecognized drug targets. Liquid biopsy-based multiomics profiling of plasma coupled with computational modeling provides a promising approach to interrogate both tumor and non-tumor derived signals, to support patient-centric personalized precision oncology. Here, we utilized a blood-based multiomics platform to identify, refine, and combine signals to categorize late-stage, treatment-naive, EGFR/ALK wild type NSCLC. Methods: Cell-free DNA (cfDNA) was extracted from 34 late-stage, treatment-naive, EGFR/ALK wild type NSCLC patients and low pass whole-genome sequencing was performed to characterize cfDNA fragments, which reflect nucleosome protection and chromatin state. Gene activation for protein-coding genes (GAP scores) was modeled from fragment distribution around transcription start sites. The abundances of 644 plasma proteins including markers of the immune response, inflammation, cancer, and DNA repair were measured. Partial least-squares discriminant analysis (PLS-DA) was used for marker selection and sample separation by smoking status with either genomics or proteomics data. Results: By statistically modeling clinical data, we identified a significant association showing never-smokers being enriched in the highest N stage, (P = 7.95E-3). Using PLS-DA, we identified proteomic (top 3 proteins: ST1A1, AXIN1, STAMPB) and GAP score (top 3 genes: CHD3, FANCF, METTL3) markers that separated patients by smoking status, suggesting underlying molecular differences. By performing pathway analysis on GAP scores, we identified 108 significant pathways enriched in the never-smoker group (FDR < 5%), 18 of which were associated with immune cell signatures, specifically myeloid cells and macrophages. Based on our previous association of IL1RN GAP scores with disease progression in NSCLC, we examined whether these results are confirmed. In this cohort, patients with high IL1RN GAP scores were significantly associated with worse lymph-node staging (N) (P = 6E-3), which is indicative of worse prognosis. Pathway analysis comparing patients with high vs low IL1RN scores revealed 102 significant pathways (FDR < 5%), including leukocyte activity and regulation of inflammatory response. Conclusion: The liquid biopsy-based multiomics platform suggests an association between never-smoker status and pathways of inflammatory response, resulting in more severe lymph-node staging. Future applications of this multiomics platform provide promise for stratification of NSCLC patients for patient-centric precision oncology. Citation Format: Zheng Feng, Danyi Wang, Francesco Vallania, Neil Smith, Anupriya Tripathi, Juergen Scheuenpflug. Liquid biopsy-based multiomics profiling using low-pass whole genome sequencing and proteomics with computational modeling reveals molecular correlates of disease severity in EGFR/ALK wild type NSCLC patients [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5113.
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Feng, Zheng, Jean-Christophe Pignon, Radwa Sharaf, Natalie Romanov, Julien Doudement, Lee A. Albacker, Noriaki Kurata, Neil R. Smith, Nobutoshi Matsushita, and Juergen Scheuenpflug. "Abstract 5737: Precision oncology driven real world clinical genomics data mining of MET alterations, TMB, and PDL-1 to empower indication agnostic patient enrollment and combination strategies." Cancer Research 82, no. 12_Supplement (June 15, 2022): 5737. http://dx.doi.org/10.1158/1538-7445.am2022-5737.
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Abstract Background: Following MET inhibitor and checkpoint inhibitor approvals, it is essential to identify cancer indications that harbor molecular alterations of interest and a thorough real-world molecular genomics based characterization of those tumors would allow to expand cancer specific indications that might benefit from MET and checkpoint inhibitors and shed light on exploring clinically efficacious combo strategies. Importantly, such an approach provides the end-to-end solutions that shall significantly contribute to clinical translation and/or back translation strategies for innovative cancer therapies. Methods: We systemically interrogated FoundationInsights®, a dataset of real-world molecular genomic tumor profiling from North American patients, and investigated the prevalence of MET amplifications, METex14 skipping and MET fusions prevalence in 62110 unique patient samples across five indications (lung adenocarcinoma [LUAD], esophageal/gastroesophageal-junction/stomach adenocarcinoma [Eso/GEJ/Sto], papillary renal cell carcinoma, hepatocellular carcinoma [HCC] and glioblastoma). MET alteration prevalence was further categorized based on tumor cell PD-L1 IHC status (22C3 pharmDx) and TMB status. Additionally, comprehensive text mining from clinicaltrials.gov and landscape overview were conducted. Results: MET amplification was the most frequent MET alteration examined with a prevalence ranging from 1.4% in HCC to 4.8% in Eso/GEJ/Sto. In HCC and LUAD, MET amplification prevalence was higher in tumors with high TMB (≥10 mutations/megabase, P<0.05). In Eso/GEJ/Sto and LUAD, MET amplification occurrence was higher in PD-L1-high tumor vs. PD-L1-low or PD-L1-neg tumors (P<0.05). METex14 skipping mutations were observed in LUAD (2.3%), rarely in the other five tumor types analyzed (≤0.1%). Lastly in LUAD, METex14 skipping mutations were more frequent in PD-L1 high tumors but not those with high TMB (P<0.05). Text mining results indicate that- while most trials use MET amplification for patient stratification- there is a distinct tendency for MET inhibitor trials to increasingly include METex14 skipping as a major selection criterion as well. Conclusions: Real world genomics corroborated MET amplification as a predominant MET alteration across various indication. The potential clinical benefit to combine MET inhibitors with PD-1/PD-L1 blockades in specific indications and specific subsets of patients is further recognized. Collectively, the comprehensive molecular profiling & text mining approaches will continue to guide application of precision medicine in clinical trial design based on appropriate biomarker selection. Citation Format: Zheng Feng, Jean-Christophe Pignon, Radwa Sharaf, Natalie Romanov, Julien Doudement, Lee A. Albacker, Noriaki Kurata, Neil R. Smith, Nobutoshi Matsushita, Juergen Scheuenpflug. Precision oncology driven real world clinical genomics data mining of MET alterations, TMB, and PDL-1 to empower indication agnostic patient enrollment and combination strategies [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5737.
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Weidinger, Inez Marita, Hoang Khoa Ly, Anthony Ramuglia, Mino Borelli, Christine Joy Querebillo, Renhao Dong, Xinliang Feng, and Matthias Schwalbe. "Understanding Active Sites in Molecular (Photo)Electrocatalysis through Vibrational Spectroelectrochemistry." ECS Meeting Abstracts MA2022-01, no. 49 (July 7, 2022): 2103. http://dx.doi.org/10.1149/ma2022-01492103mtgabs.
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Molecularly defined (photo)electrocatalysts have great potential to perform important energy conversion reactions with high efficiency and selectivity. A particular advantage is their modular design, which allows their reactivity to be tailored to a specific reaction. However, to advance their rational development, a deep mechanistic understanding of the catalytic reactions is required. In situ vibrational spectrochemistry, in particular confocal Raman and infrared absorption spectroscopy, is an extremely powerful method to gain deep insights into the structure and reactivity of electrode-immobilized molecular catalytic systems under operando conditions [1]. Since both vibrational spectroscopic techniques have different selection rules, complementary information about the system under operando conditions can be obtained. In my talk, selected research examples will be used to present the different aspects and features of (photo)electrocatalysis that can be visualized using vibrational spectrochemistry. The target systems presented include, on the one hand, porphyrin- and phthalocyanine-based systems for electrocatalytic oxygen and CO2 reduction [2,3] and, on the other hand, conjugated acetylene polymers for photoelectrocatalytic hydrogen evolution [4]. Spectra evaluation under operando conditions allowed us to demonstrate charge separation and ligand binding within these catalysts, identify the active sites during catalysis, and gain insight into the redox properties, reaction intermediates as well as synergistic effects of dual active sites. [1] H. K. Ly, I. M. Weidinger, Chem. Commun. 2021, 57, 2328-2342 [2] T. R. Ramuglia, V. Budhija, K. H. Ly, M. Marquardt, M. Schwalbe, I. M. Weidinger, ChemCatChem, 2021, 13, 3934. [3] H. Zhong, M. Ghorbani-Asl, K. H. Ly, J. Zhang, J. Ge, M. Wang, Z. Liao, D. Makarov, E. Zschech, E. Brunner, I.M. Weidinger, J. Zhang, A. V. Krasheninnikov, S. Kaskel, R. Dong, X. Feng, Nat. Comm. 2020, 11, 1409. [4] M. Borelli, C. J. Querebillo, D. L. Pastoetter, T. Wang, A. Milani, C. Casari, H. K. Ly, F. He, Y. Hou, C. Neumann, A. Turchanin, H. Sun, I. M. Weidinger, X. Feng, Angew. Chemie Int. Ed. 2021, 60 (34), 18876-18881.
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Wang, Zhen-xin, Xi-long Feng, Chengwei Liu, Jin-ming Gao, and Jianzhao Qi. "Correction: Wang et al. Diverse Metabolites and Pharmacological Effects from the Basidiomycetes Inonotus hispidus. Antibiotics 2022, 11, 1097." Antibiotics 11, no. 11 (November 21, 2022): 1671. http://dx.doi.org/10.3390/antibiotics11111671.
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In the original publication, there were publisher errors in the names of authors Zhen-xin Wang, Xi-long Feng and Jin-ming Gao and affiliation (1) of the first, second, fourth and fifth authors (name of the Key Laboratory and city) [...]
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Dainian, Zhang. "The Historical Significance of Feng Youlan’s Zhen Yuan Liu Shu." Journal of Chinese Philosophy 21, no. 3-4 (February 10, 1994): 283–301. http://dx.doi.org/10.1163/15406253-0210304009.
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Dainian, Zhang. "THE HISTORICAL SIGNIFICANCE OF FENG YOULAN'S ZHEN YUAN LIU SHU." Journal of Chinese Philosophy 21, no. 3-4 (September 1994): 283–301. http://dx.doi.org/10.1111/j.1540-6253.1994.tb00690.x.
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Wei, Xiameng. "Deep Learning-Based Artificial Neural Network-Cellular Automata Model in Constructing Landscape Gene in Shaanxi Ancient Towns under Rural Revitalization." Computational Intelligence and Neuroscience 2022 (July 16, 2022): 1–12. http://dx.doi.org/10.1155/2022/1340038.
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With the development of modern industrialization, the rational planning of land resources, especially rural settlements (RSs), has become an important part of rural revitalization. Optimizing the RS spatial layout and enhancing its evolution simulation can encourage effective land resource allocation. It helps improve rural residents’ production and living standards, alleviates the pressure of urban and rural land conflicts, and promotes the common development of urban and rural economies. This work mainly uses the ANN-CN (artificial neural network-cellular automata) model to study the cultural landscape gene construction of ancient towns in Shaanxi. First, RSs’ spatial layout and landscape pattern index (LPI) in Shaanxi are analyzed. Second, the ANN-CA model is designed using the artificial neural network (ANN). Finally, Hua Yang Ancient Town in southern Shaanxi, Feng Huo Town in Guan Zhong, and Zhong Jiao Town in Northern Shaanxi are selected as the research objects. The influencing factors of spatial layout are extracted, and the evolution extracted of spatial layout is simulated based on the ANN-CA model. The simulation experiment finds that the area change of Hua Yang Ancient Town is more obvious than that of the other two ancient towns, with a change rate of 6.98%. Although the area change rate of Feng Huo Town is 19.79%, the actual change area is less than that of Hua Yang Ancient Town. Second, comparing the simulation accuracy of the model under different parameters, we can obtain the most suitable parameter for predicting the ancient towns’ land-use type and construing landscape gene land. Specifically, for Hua Yang Ancient Town, T = 0.9 and the random disturbance parameter α = 1.0. For Zhong Jiao Town, T = 0.8 and α = 1.0. For Feng Huo Town, T = 0.9 and α = 1.0. It is hoped that this work can further carry forward Shaanxi’s traditional culture and carry out the protective development of traditional rural buildings.
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Alaufey, Rayan, and Maureen H. Tang. "A Mechanistic Investigation of Electrochemical Ozone Production Using Nickel and Antimony Doped Tin Oxide in Non-Aqueous Electrolytes." ECS Meeting Abstracts MA2022-02, no. 64 (October 9, 2022): 2389. http://dx.doi.org/10.1149/ma2022-02642389mtgabs.
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Electrochemical water splitting to produce hydrogen has attracted great interest as an environmentally-friendly renewable fuel. While cathodic hydrogen evolution (HER) is a relatively fast process that produces a valuable chemical, the anodic oxygen evolution reaction (OER) is a slow process that adds little to no economic value to water splitting.1,2 Generating a high-performance oxidizer such as ozone instead of oxygen could make water splitting more economically feasible because of the added value of ozone. However, electrochemical ozone production (EOP) catalysts are typically hindered by low current efficiencies, poor selectivity, low stability, and high energy demands, which limit the industrial application of this reaction.3,4 Further improvements in catalyst performance could be achieved by better understanding the mechanism of ozone production. Nickel and antimony doped tin oxide (Ni/Sb-SnO2, NATO) is currently reported to have the highest EOP current efficiency at room temperature. However, the mechanism of EOP on NATO electrodes has not yet been established. A primary complication when studying the mechanism of EOP using NATO electrocatalysts in water is that oxygen atoms in the ozone molecule can originate from sources other than water, such as dissolved molecular oxygen or the electrocatalyst oxide lattice.1,5,6 In this work, lattice oxygen participation in EOP is investigated by replacing water with acetonitrile, a polar aprotic solvent without oxygen atoms. Our results show that ozone can be generated in acetonitrile in similar quantities as aqueous conditions.2 These quantities are inconsistent with a 6-electron process based on calculated current efficiencies. Furthermore, the addition of small quantities of water is shown to have a negative impact on ozone generation. The origin of this impact is thought to not be mechanistic in nature. Instead, we suggest that adding water to the mixture leads to the generation of hydroxide ions which act as ozone scavengers. To our knowledge, this is the first report of electrochemical ozone production in a non-aqueous solvent. Future work will more conclusively determine the origin of oxygen atoms using isotopic labeling. Furthermore, the ability of nonaqueous solvents to stabilize reactive oxygen species and impact selectivity will be investigated. Utilizing the knowledge gained by studying ozone generation in nonaqueous solvents, it might be possible to design a better EOP system which could enhance the applicability of this reaction. (1) Lees, C. M.; Lansing, J. L.; Morelly, S. L.; Lee, S. E.; Tang, M. H. Ni- and Sb-Doped SnO2 Electrocatalysts with High Current Efficiency for Ozone Production via Electrodeposited Nanostructures. J. Electrochem. Soc. 2018, 165 (16), E833. https://doi.org/10.1149/2.0051816jes. (2) James L. Lansinga±, Lingyan Zhaob, Tana Siboonruanga, N. Harsha Attanayakea, Angela B. Leob, Peter Fatourosb, So Min Parkc, Kenneth R. Grahamc, John A. Keithb, Maureen Tang*a. Gd-Ni-Sb-SnO2 Electrocatalysts for Active and Selective Ozone Production. (3) Christensen, P. A.; Attidekou, P. S.; Egdell, R. G.; Maneelok, S.; Manning, D. A. C.; Palgrave, R. Identification of the Mechanism of Electrocatalytic Ozone Generation on Ni/Sb-SnO 2. J. Phys. Chem. C 2017, 121 (2), 1188–1199. https://doi.org/10.1021/acs.jpcc.6b10521. (4) Wang, Y.-H.; Chen, Q.-Y. Anodic Materials for Electrocatalytic Ozone Generation. Int. J. Electrochem. 2013, 2013, 1–7. https://doi.org/10.1155/2013/128248. (5) Jiang, W.; Wang, S.; Liu, J.; Zheng, H.; Gu, Y.; Li, W.; Shi, H.; Li, S.; Zhong, X.; Wang, J. Lattice Oxygen of PbO 2 Induces Crystal Facet Dependent Electrochemical Ozone Production. J. Mater. Chem. A 2021, 9 (14), 9010–9017. https://doi.org/10.1039/D0TA12277G. (6) Feng, J.; Johnson, D. C.; Lowery, S. N.; Carey, J. J. Electrocatalysis of Anodic Oxygen‐Transfer Reactions: Evolution of Ozone. J. Electrochem. Soc. 1994, 141 (10), 2708–2711. https://doi.org/10.1149/1.2059184.
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Smith, Neil R., Jean-Christophe Pignon, Scott A. Shell, Arialle Yablonovitch, Juergen Scheuenpflug, and Zheng Feng. "Abstract 5748: Longitudinal evaluation of ctDNA molecular response for monitoring clinical benefit and investigating treatment related impacts in metastatic colorectal cancer patients treated with different drug regimens." Cancer Research 82, no. 12_Supplement (June 15, 2022): 5748. http://dx.doi.org/10.1158/1538-7445.am2022-5748.
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Abstract Introduction: The patient-centric liquid biopsy approach to detect changes in ctDNA provides an early indication of treatment response to therapies and is an emerging tool to aid clinicians in treatment decision making. We investigated this approach in the mCRC palliative treatment setting by exploring the potential clinical utility of the validated Guardant Health Molecular Response (MR) algorithm. Methods: Longitudinal plasma samples (70) were collected from 14 patients with mCRC and treated using chemotherapy alone or combined with one or more targeting agents. All patients were clinically stable or had clinical benefit over the course of plasma collection. 6 patients had radiological response by RECISTv1.1 and 10 had tumor RAS/RAF mutation status. Baseline and longitudinal plasma samples (27-276 days post treatment) were tested by GuardantOMNI® 500-gene liquid biopsy assay. Selection of qualifying alterations and generation of MR scores were pursued using the Guardant Health MR algorithm. Results: Thirteen patients were evaluable for MR by having somatic alterations at each timepoint that exceeded the molecule threshold required for reliable MR score calculation. Mean variant allele fraction (mVAF) of all plasma samples outside the 4-10 week on-treatment window trended in the same direction as the early on-treatment plasma samples when compared to baseline. Eleven patients experienced a consistent reduction in mVAF compared to baseline. One outlier showed a mVAF increase at the earliest on-treatment timepoint, followed by molecular clearance at all subsequent timepoints. GuardantOMNI® detected a frameshift APC alteration at the baseline of this patient, which may have limited the tumor response to the chemotherapy. The second outlier patient was originally diagnosed as RAS/RAF wild-type and treated with anti-EGFR and anti-PD-L1. MR scores for this patient across all timepoints reflected an increase in mVAF compared to baseline. Notably, GuardantOMNI® detected a low level KRAS alteration in the baseline plasma sample of this patient, indicating this patient’s disease had elements of KRAS alteration that were not detected by tissue-based testing. All 6 patients with RECIST 1.1 information had partial responses (PR) and 5 showed a decrease in the MR score. The one patient whose MR score did not align with radiographic assessment was the mis-genotyped KRAS mutation-positive patient, who is under further investigation. Conclusions: We demonstrate that ctDNA analysis of plasma samples taken at early timepoints (4-10 weeks) after treatment initiation are sufficient to support MR assessments and highlight the advantage of the patient-centric liquid biopsy approach over genetic testing of diagnostic tumor samples in detecting potential resistance mutations prior to therapy. Citation Format: Neil R. Smith, Jean-Christophe Pignon, Scott A. Shell, Arialle Yablonovitch, Juergen Scheuenpflug, Zheng Feng. Longitudinal evaluation of ctDNA molecular response for monitoring clinical benefit and investigating treatment related impacts in metastatic colorectal cancer patients treated with different drug regimens [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5748.