Academic literature on the topic 'Feline infectious peritoniti'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Feline infectious peritoniti.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Journal articles on the topic "Feline infectious peritoniti"
1
TZIVARA (Α. ΤΖΙΒΑΡΑ), A., and S. K. KRITAS (Σ.Κ. ΚΡΗΤΑΣ). "Feline Coronavirus infections and feline infectious peritonitis." Journal of the Hellenic Veterinary Medical Society 50, no. 3 (January 31, 2018): 199. http://dx.doi.org/10.12681/jhvms.15710.
Full textAbstract:
Cats are susceptible to infection with several different strains of feline Coronavirus. Depending on the involved strain, clinical signs may range from asymptomatic infection to gastrointestinal disease or fibrinous serositis and disseminated vasculitis, commonly known as feline infectious peritonitis (FIP). Excretion of virus by infected cats into the environment occurs by faeces, oronasal secretions and urine. The feline coronaviruses are rapidly inactivated by most disinfectants. Clinical diagnosis of Coronavirus infection is made by evaluating the case history, physical findings, laboratory results, Coronavirus antibody titers and tissue biopsy. A temperature-sensitive feline infectious peritonitis virus vaccine has become available for healthy 16 week of age or older cats.
2
Avila, Vicente, and Daniel Rissi. "Ulcerative dermatitis due to feline infectious peritonitis virus infection in a cat." Brazilian Journal of Veterinary Pathology 13, no. 1 (March 31, 2020): 48–50. http://dx.doi.org/10.24070/bjvp.1983-0246.v13i1p48-50.
Full text
3
Kipar, A., and M. L. Meli. "Feline Infectious Peritonitis." Veterinary Pathology 51, no. 2 (February 25, 2014): 505–26. http://dx.doi.org/10.1177/0300985814522077.
Full text
4
Andrew, Stacy E. "Feline Infectious Peritonitis." Veterinary Clinics of North America: Small Animal Practice 30, no. 5 (September 2000): 987–1000. http://dx.doi.org/10.1016/s0195-5616(00)05002-6.
Full text
5
Hartmann, Katrin. "Feline infectious peritonitis." Veterinary Clinics of North America: Small Animal Practice 35, no. 1 (January 2005): 39–79. http://dx.doi.org/10.1016/j.cvsm.2004.10.011.
Full text
6
Kennedy, Melissa A. "Feline Infectious Peritonitis." Veterinary Clinics of North America: Small Animal Practice 50, no. 5 (September 2020): 1001–11. http://dx.doi.org/10.1016/j.cvsm.2020.05.002.
Full text
7
Ermakov, Aleksey, Tatyana Lipilkina, Pavel Lipilkin, and Igor Popov. "Feline coronavirus infection." E3S Web of Conferences 273 (2021): 02025. http://dx.doi.org/10.1051/e3sconf/202127302025.
Full textAbstract:
The main feature of feline coronavirus infection is its manifestation in the form of peritonitis. Feline infectious peritonitis is a highly lethal disease that lacks primary prevention and therapy. Therefore, feline infectious peritonitis is an epizootic problem in the near future. In our review, we demonstrate the current clinical, diagnostic, and therapeutic interventions for feline infectious peritonitis, as well as hypotheses of origin.
8
Sweet, Arjun N., Nicole M. André, Alison E. Stout, Beth N. Licitra, and Gary R. Whittaker. "Clinical and Molecular Relationships between COVID-19 and Feline Infectious Peritonitis (FIP)." Viruses 14, no. 3 (February 26, 2022): 481. http://dx.doi.org/10.3390/v14030481.
Full textAbstract:
The emergence of severe acute respiratory syndrome 2 (SARS-CoV-2) has led the medical and scientific community to address questions surrounding the pathogenesis and clinical presentation of COVID-19; however, relevant clinical models outside of humans are still lacking. In felines, a ubiquitous coronavirus, described as feline coronavirus (FCoV), can present as feline infectious peritonitis (FIP)—a leading cause of mortality in young cats that is characterized as a severe, systemic inflammation. The diverse extrapulmonary signs of FIP and rapidly progressive disease course, coupled with a closely related etiologic agent, present a degree of overlap with COVID-19. This paper will explore the molecular and clinical relationships between FIP and COVID-19. While key differences between the two syndromes exist, these similarities support further examination of feline coronaviruses as a naturally occurring clinical model for coronavirus disease in humans.
9
Nururrozi, Alfarisa, Agistanya Andimi, Yanuartono Yanuartono, and Soedarmanto Indarjulianto. "Studi Retrospektif Profil Hemogram Kasus Peritonitis Menular Tipe Efusif pada Kucing." Jurnal Veteriner 23, no. 1 (March 31, 2022): 112–20. http://dx.doi.org/10.19087/jveteriner.2022.23.1.112.
Full textAbstract:
Feline Infectious Peritonitis (FIP) merupakan penyakit pada kucing dengan tingkat mortalitas tinggi, sehingga membutuhkan diagnosa yang cepat untuk kepentingan prognosis. Penelitian ini bertujuan mengevaluasi profil hemogram kucing yang terinfeksi FIP tipe efusif. Dua puluh ekor kucing yang telah terdiagnosa FIP di Klinik Hewan Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Hewan Universitas Gadjah Mada digunakan dalam penelitian. Diagnosa FIP ditegakkan berdasarkan pemeriksaan klinis, ultrasonografi, rontgen, uji rivalta, dan uji rapid test. Profil hemogram yang dianalisis meliputi gambaran hematologi rutin dan kimia darah. Profil hemogram pada kucing terinfeksi FIP tipe effusif, diketahui mengalami penurunan hematokrit, hiperproteinemia, dan leukositosis dengan rerata masing-masing 22,9±7,4%; 9,0±2,2 g/dL; 22425±4116 sel/mm3. Gambaran eritrosit, hemoglobin dan fibrinogen masih dalam kisaran normal. Sebanyak 90% kucing terinfeksi FIP efusif mengalami neutrofilia dan 75% kucing mengalami limfopenia dengan rerata masing-masing 20066±3337 sel/mm3 dan 1861±1818sel/mm3. Profil hemogram kimia darah diketahui 60% kucing mengalami kenaikan SGPT dan SGOT dengan rerata 138,4±72,3 IU/L dan 101±60,5 IU/L. Sebanyak 90% kucing mengalami hiperglobulinemia dengan rerata 6,7±0,8 g/dL dan semua kucing memiliki rasio albumin:globulin yang rendah dengan rerata 0,3±0,1. Kucing terdiagnosa FIP efusif memiliki gambaran hemogram leukositosis, neutrofilia, limfopenia, hiperglobulinemia, dan penurunan rasio albumin-globulin.
10
Hora, A. S., P. O. Tonietti, S. A. Taniwaki, K. M. Asano, P. Maiorka, L. J. Richtzenhain, and P. E. Brandão. "Feline Coronavirus 3c Protein: A Candidate for a Virulence Marker?" BioMed Research International 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/8560691.
Full textAbstract:
Feline infectious peritonitis virus (FIPV) is highly virulent and responsible for the highly fatal disease feline infectious peritonitis (FIP), whereas feline enteric coronavirus (FECV) is widespread among the feline population and typically causes asymptomatic infections. Some candidates for genetic markers capable of differentiating these two pathotypes of a unique virus (feline coronavirus) have been proposed by several studies. In the present survey, in order to search for markers that can differentiate FECV and FIPV, several clones of the 3a–c, E, and M genes were sequenced from samples obtained from cats with or without FIP. All genes showed genetic diversity and suggested the presence of FCoV mutant spectrum capable of producing a virulent pathotype in an individual-specific way. In addition, all the feline coronavirus FIPV strains demonstrated a truncated 3c protein, and the 3c gene was the only observed pathotypic marker for FCoVs, showing that 3c gene is a candidate marker for the distinction between the two pathotypes when the mutant spectrum is taken into account.
Dissertations / Theses on the topic "Feline infectious peritoniti"
1
Hora, Aline Santana da. "Diversidade gênica do coronavírus felino em populações virais entéricas e sistêmicas intra e inter-hospedeiros." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-22072014-140450/.
Full textAbstract:
O coronavírus felino (FCoV) ocorre sob uma grande diversidade gênica de amostras e é classificado em dois patotipos: o coronavírus felino entérico (FECoV) e o vírus da peritonite infecciosa felina (FIPV). O patotipo FIPV é altamente virulento e responsável pelo desenvolvimento de uma doença altamente fatal, denominada de peritonite infecciosa felina (PIF). Já o FECoV apresenta-se amplamente disseminado na população felina e é responsável na maioria das vezes por infecção assintomática. Atualmente, nenhum marcador gênico conhecido é capaz de diferenciar os patotipos FECoV de FIPV. O presente estudo foi dividido em dois capítulos. No primeiro capítulo, objetivou-se avaliar a diversidade molecular do gene da membrana (M) em 190 amostras provenientes de 5 gatos sem manifestações de PIF (PIF-) e de 10 gatos com manifestações clínicas e histopatológicas de PIF (PIF+). Com esse estudo, conclui-se que tanto a hipótese de mutação in vivo do FECoV para FIPV, quanto a hipótese de transmissão entre gatos do patotipo FIPV são plausíveis. No segundo capítulo, com o objetivo de avaliar a diversidade dos genes 3a-c, E e M foram sequenciados clones de amplicons para estes genes obtidos, de 6 gatos PIF+ e 2 gatos PIF-. Os genes 3a-c, E e M apresentaram diversidade gênica que confere a constituição das quasiespécies de coronavírus felino com probabilidade de emergência do patotipo de alta virulência, mas de um modo hospedeiro-específico. Com o segundo estudo, conclui-se que as linhagens FIPV de coronavírus felino apresentaram a proteína 3c truncada, sendo o gene 3c o único marcador de patotipo dos FCoVs observado dentre os genes estudados.Feline coronavirus (FCoV) occurs as a large genic diversity of strains and is classified as two pathotypes: feline enteric coronavirus (FECoV) and feline infectious peritonitis virus (FIPV). The FIPV pathotype is highly virulent and responsible for the onset of a highly fatal disease named feline infectious peritonitis (FIP), while the FECoV pathotype is widely disseminated in feline populations leading mostly to asymptomatic infections. No genic marker is currently known to differentiate the FECoV and FIPV pathotypes. This study has been divided in two chapters. In the first chapter, the aim was to evaluate the molecular diversity of the membrane (M) gene in 190 samples from 5 cats without FIP (FIP-) and 10 cats with clinical and histopathological evidence of FIP (FIP+). The conclusion of this study is that both the in vivo mutation hypothesis in the FECoV-to-FIP direction and the hypothesis of FIPV transmission amongst cats are plausible. In the second chapter, aimed to evaluate the diversity of genes 3a-c, E and M, clones of amplicons for these genes were obtained and sequenced from samples from six FIP+ and 2 FIP- cats. Genes 3a-c, E and M show a genic diversity that results in a quasispecies constitution of FCoV that leads to the probability of the emergence of the highly virulent pathotype in a host-specific way. The conclusion of this second study is that FIPV lineages show a truncated form of the 3C protein, making the 3c gene the only pathotype marker for FCoV observed amongst the genes studied herein.
2
Almeida, Cláudia Maria Urmal. "Peritonite infeciosa felina : casuística e formas clínicas." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2020. http://hdl.handle.net/10400.5/20190.
Full textAbstract:
Dissertação de Mestrado Integrado em Medicina VeterináriaA peritonite infeciosa felina (PIF) é uma doença patogénica e fatal, causada pelo coronavírus felino (FCoV), capaz de induzir uma reação inflamatória sistémica. A PIF é associada a falhas no sistema imunitário, nomeadamente à inibição da resposta humoral e celular, havendo um conjunto de fatores genéticos, ambientais e do hospedeiro que predispõem para o seu aparecimento. Estudos recentes sugerem novos fármacos, promissores na cura da PIF. O GS-441524 revela-se muito promissor para todas as formas clínicas de PIF, relevando altas taxas de remissão. Contudo, não se encontra comercialmente disponível e são ainda necessários estudos para o licenciamento deste medicamento. O presente estudo teve como objetivo caracterizar gatos diagnosticados com PIF na Unidade de Isolamento de Doenças Infeciosas do Hospital Veterinário da Faculdade de Medicina Veterinária da Universidade de Lisboa, entre outubro de 2013 e novembro de 2019. Com o auxílio dos médicos responsáveis por este departamento foi possível a obtenção de dados, não só relativamente ao historial dos animais, como resultados de exames complementares. O diagnóstico foi realizado através de necropsia ou por deteção de coronavírus através de PCR em tempo real a partir de líquido de derrame torácico ou abdominal. A partir de janeiro de 2019 o diagnóstico foi otimizado recorrendo-se à deteção de mutações do coronavírus por PCR em tempo real em diferentes amostras (sangue, líquido de derrame, granulomas ou linfonodos). Analisando os dados disponíveis, foi possível identificar na presente população os seguintes fatores de risco: idade, fator raça, origem e a presença de pelo menos um fator de stress antes do aparecimento dos sinais clínicos. Perante os desafios económicos que esta doença carece desenvolveu-se um fluxograma para direcionar os recursos financeiros de forma a obter um diagnostico definitivo ante-mortem, PCR em tempo real para deteção de mutações, e quando não é possível, post-mortem.
ABSTRACT - Feline Infectious Peritonitis: casuistry and clinical forms - Feline infectious peritonitis (FIP) is a fatal and pathogenic disease caused by the feline coronavirus, which is responsible for inducing an inflammatory reaction. FIP is responsible for a number of faults in the immune system, namely the inhibition of humoral and cellular response. A set of genetic, environmental and host factors can predispose its appearance. Recent studies have shown promising new drugs in the treatment of FIP. GS-441524 has been reported as a very promising drug in the treatment of all clinical forms of FIP, with high rates of remission. However, it is not yet commercially available and studies are required to its licence. The present study aimed to study cats diagnosed with FIP, in the Infectious Diseases Isolation Unit of the Veterinary Hospital of the Faculty of Veterinary Medicine of the University of Lisbon, between October 2013 and November 2019. With the help of the doctors responsible for this department, it was possible to collect data regarding the animal’s history, complementary test results. The diagnosis of FIP was made through autopsy or real time PCR positive for feline coronavirus in thoracic or abdominal fluid. Since January of 2019, the diagnosis was improved by using the real time PCR detection of mutation of feline coronavirus in different samples (blood, effusion fluid and granuloma or lymph nodes). With the analysis of the available data, it was possible to identify in the present population the following risk factors: age, being of breed, origin and the presence of at least one stress factor before the appearance of clinical signs. Facing the economic challenges of FIP, a flowchart has been developed to direct the financial resources in order to obtain a definitive ante-mortem diagnosis, real time PCR with detection of mutations, and if not possible, post-mortem.
N/A
3
Silva, Filipa de Melo Gago Vassalo e. "Avaliação da carga viral do Coronavírus felino e sua relação com o perfil de expressão de mediadores imunitários, em animais portadores e com Peritonite Infecciosa." Master's thesis, Universidade de Lisboa. Faculdade de Medicina Veterinária, 2013. http://hdl.handle.net/10400.5/6270.
Full textAbstract:
Dissertação de Mestrado Integrado em Medicina VeternáriaA infecção pelo coronavírus felino (FCoV) em gatos, não só leva à excreção do vírus após infecção intestinal mas também à infecção sistémica, podendo manter-se assintomática ou manifestar-se como Peritonite Infecciosa Felina (PIF), uma doença fatal. Estima-se que 80 a 90% da população felina esteja infectada por este vírus mas apenas 5 a 12% desenvolvem a doença. O FCoV divide-se em dois subtipos, o tipo I e o tipo II, sendo o primeiro o responsável pela maioria das infecções. A patogénese da doença é complexa e não é totalmente conhecida, não estando claramente identificado qual o papel do sistema imunitário no seu estabelecimento e manutenção. Considera-se que uma forte resposta imunitária celular pode prevenir a doença e, pelo contrário, que uma forte resposta imunitária humoral pode levar ao estabelecimento da doença, na sua forma exsudativa ou não exsudativa. De forma a conhecer o perfil imunitário de animais naturalmente infectados pelo FCoV foram determinados os níveis de transcrição do mRNA das citoquinas IL-10, IL-4, IL-12p35, TNF-α e IFN-γ em amostras de sangue dos animais em estudo, através de RTqPCR. Estes foram divididos em três grupos para comparação dos resultados: o primeiro sem sintomatologia associada a PIF (I); o segundo com sintomatologia gastrointestinal suspeita de PIF (II) e o terceiro com sintomatologia neurológica e ocular suspeita de PIF (III). Foi ainda realizada a subtipificação viral e determinada a carga viral em líquido de derrame e em zaragatoas rectais e/ou amostras de fezes, avaliando o nível de excreção viral destes animais na tentativa de associar ao perfil de citoquinas. Apesar da tentativa de realizar o estudo com grupos com a maior homogeneidade possível, observou-se muita variabilidade nos níveis de transcrição. A carga viral entre os três grupos revelou-se sem diferenças significativas pelo que fica por responder o seu efeito no desenvolvimento e manutenção da doença. Já nos perfis de citoquinas, o TNF-α revelou-se inesperadamente elevado em animais naturalmente infectados e assintomáticos e diminuído nos dois grupos naturalmente infectados mas com sintomatologia suspeita de PIF. Os perfis da expressão de citoquinas aparentemente demonstram uma resposta predominantemente celular nos grupos I e III e mista no grupo II, apesar de estatisticamente não se terem verificado diferenças entre os grupos.
ABSTRACT - Evaluation of feline coronavirus viral load and its relation with the expression profile of immune mediators on healthy carriers and on animals with Feline Infectious Peritonitis - Infection with feline coronavirus (FCoV) in cats, not only leads to virus elimination on faeces after intestinal infection but also to systemic infection that may remain asymptomatic or manifest as Feline Infectious Peritonitis (FIP), a fatal disease. It is estimated that 80 to 90% of the cat population is infected with this virus, but only 5 to 12% develop the disease, one of the most important viral diseases in cats. FCoV can be divided into two types, type I and type II, the former being responsible for the majority of infections. The pathogenesis of the disease is complex and the role of the immune system in the establishment and maintenance of disease remains unclear. It is considered that a strong cellular immune response can prevent the disease, and, conversely, that a strong humoral immune response may lead to the establishment of the disease whether on in its exudative or non-exudative form. In order to learn about the immune profile of naturally infected cats with FCoV, the mRNA transcription levels of IL-10, IL-4, IL-12p35, TNF-α and IFN-γ cytokines was measured by RTqPCR in blood samples. The animals were divided into three groups for comparison purposes: the first had no symptoms associated with PIF (I); the second had gastrointestinal symptoms suspected of FIP (II) and the third had ocular and neurologic symptoms suspected of FIP (III). Furthermore viral subtyping was performed and viral load was determined in effusions and in rectal swabs and/or faecal samples, assessing the level of viral shedding of these animals in an attempt to associate with the cytokine profile. Despite the attempts to arrange the study groups with the greatest possible homogeneity, there was significative variability on the transcription levels. The viral load between the three groups revealed no significant differences, leaving the effect of viral load in the development and maintenance of the disease unanswered. The TNF-α profile proved unexpectedly high in naturally infected and asymptomatic cats and decreased in both naturally infected with suspected symptoms of FIP groups. The expression profiles of cytokines apparently show a predominantly cellular response in groups I and III and mixed in group II, although there have been no statistically differences between groups.
4
McArdle, Francis. "Studies on feline infectious peritonitis." Thesis, University of Liverpool, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316969.
Full text
5
STRANIERI, ANGELICA. "INNOVATIVE APPROACHES FOR THE CLINICO-PATHOLOGICAL DIAGNOSIS OF FELINE INFECTIOUS PERITONITIS AND FELINE CORONAVIRUS INFECTION." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/488776.
Full textAbstract:
La peritonite infettiva felina (FIP) è una patologia letale dei felidi, a patogenesi virale ed
immunomediata. La propensione dell’agente eziologico alle mutazioni – coronavirus felino, FCoV –
e la sintomatologia spesso aspecifica, rendono questa patologia complessa sia dal punto di vista
diagnostico che patogenetico. Non si è ancora a conoscenza, infatti, della mutazione virale
responsabile della patologia, non esiste ancora un gold standard per la diagnosi intra vitam e non
è ancora disponibile una terapia valida. Lo scopo di questa tesi è di tentare di chiarire alcuni di
questi aspetti. I primi due obiettivi (studio I e II) erano diretti allo sviluppo di un test per la diagnosi
di FIP in forma effusiva. In particolare, è stata valutata l’accuratezza diagnostica del valore
ottenuto dal rapporto tra le due conte leucocitarie fornite dal Sysmex XT-2000iV (Δ total nucleated
cell count – TNCC) su campioni di versamento FIP indotto. Successivamente, è stato valutata la
possibilità di effettuare lo stesso test su surnatanti di versamenti dopo aggiunta di sangue intero
felino, in modo da poter ottenere questo valore su campioni congelati o con risultati dubbi ad altri
esami. Il terzo scopo (studio III) era volto a confermare o smentire la presenza di pattern
elettroforetici atipici in corso di FIP, come registrato nel nostro laboratorio negli ultimi anni. E’
stato quindi svolto uno studio retrospettivo per confrontare pattern elettroforetici in due periodi
di tempo diversi. Il quarto obiettivo (studio IV) si prefissava di valutare l’accuratezza diagnostica di
diversi test, sia clinico patologici che molecolari, per trovare il miglior test o la miglior
combinazione di test per la diagnosi di FIP in vivo. Nello stesso studio è stato anche valutato il
sequenziamento del gene spike (S), ultimamente proposto come discriminante, quando mutato,
tra i due patotipi del FCoV. Il quinto scopo (studio V) era di mettere a punto una metodica
molecolare isotermica (loop isothermal amplification method – LAMP) per il rilevamento del FCoV.
Questa metodica, essendo veloce ed economica, potrebbe facilitare l’identificazione dei gatti
eliminatori del FCoV o, per alcuni campioni, la diagnosi di FIP. Durante il mio percorso di dottorato
ho anche partecipato ad un progetto sotto la supervisione della prof. Séverine Tasker e della
dott.ssa Emi Barker dell’università di Bristol. Questo progetto (studi VI e VI.1) ha lo scopo di
scoprire la vera prevalenza, in un ampio numero di tessuti, fluidi e feci ottenute da gatti affetti e
non affetti da FIP, di due mutazioni del gene spike considerate ultimamente come co-responsabili
della FIP.
Gli studi I e II hanno dimostrato che il ΔTNC può essere usato per diagnosticare la FIP con buona
accuratezza. Lo studio III ha confermato che i pattern elettroforetici tipici di FIP sono meno
frequenti negli ultimi anni, possibilmente per modificazioni nella patogenicità dei FCoVs. Dallo
studio IV si evince che i test molecolari possono confermare la diagnosi di FIP, ma che solo l’AGP
puo’ escluderla; l’esame citologico dei versamenti dovrebbe essere il test di scelta sui versamenti,
mentre sui tessuti il sequenziamento del gene S dovrebbe essere usato per confermare la
diagnosi, mentre la PCR 3’ UTR PCR quando la FIP è meno probabile. La metodica LAMP
sviluppata nello studio V si è rivelata molto specifica ma poco sensibile, dimostrandosi un buon
test per confermare la presenza di FCoV in campioni biologici, ma non per escluderla. Infine, lo
studio VI ha messo in evidenza la presenza di coronavirus mutati anche nelle feci di gatti non
affetti da FIP, mostrando che i successivi progressi in questo studio metteranno in evidenza nuovi
aspetti della patogenesi della FIP.Feline infectious peritonitis (FIP) is a deadly disease of felids with a viral and immune-mediated pathogenesis. The nature of the etiological agent – feline coronavirus, FCoV – and the non specific clinical presentation make this disease particularly challenging both from a pathogenetic and a diagnostic point of view. Many aspects still represent an issue, like not knowing the mutation(s) responsible for the development of FIP, the lack of a gold standard for the diagnosis of FIP in vivo and the absence of an effective treatment. This thesis was aimed to clarify some of these aspects, specifically: a novel test on effusions was developed (namely, Δ total nucleated cell count – ΔTNC – i.e. the ratio between the two white blood cell count provided by the Sysmex XT-2000iV analyzer) (studies I and II); the frequency of atypical serum protein electrophoresis (SPE) patterns in cats with FIP, anecdotally reported during our diagnostic activity (study III) was investigated, a comparison of clinico-pathological and molecular tests for the diagnosis of FIP (study IV) was performed, a loop isothermal amplification method (LAMP) for the detection of FCoV was developed(study V) and an investigation on the prevalence of two mutations of the spike (S) protein gene in a wide number of samples from FIP and non-FIP cats was carried out (this latter study developed during an externship at the University of Bristol in collaboration with Prof. Séverine Tasker and Dr. Emi Barker) (study VI). The results of studies I and II demonstrated that the ΔTNC is a reliable method to support the diagnosis of FIP either on fresh or on frozen effusions. Study III confirmed that SPE profiles consistent with FIP are less frequent in recent years than in the past, possibly due to changes in the pathogenic characteristics of the FCoVs. However, study IV demonstrated that: on blood molecular tests may support a clinical diagnosis of FIP but none of the test, except the measurement of a1 acid-glycoprotein (AGP) may rule out this disease; cytology should be preferred on effusions either to exclude or confirm the disease and, on tissues, S gene sequencing should be preferred when histology is highly consistent with FIP while 3’ UTR PCR when FIP is less likely; the LAMP method developed in study V may be used to confirm the presence of FCoVs in the samples but is poorly sensitive and cannot exclude the presence of FCoVs. Finally, pyrosequencing of FCoV performed in study VI demonstrated the presence of gene S mutations also in FCoVs from fecal samples. The analysis of sequences recorded in this latter study, however, is still ongoing and future results may provide new insights on the pathogenesis and diagnosis of FIP.
6
McDonagh, Phillip. "Novel antiviral strategies for feline coronavirus and feline calicivirus." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/12331.
Full textAbstract:
Feline coronavirus (FCoV) and feline calicivirus (FCV) commonly infect domestic cats, and are an important cause of morbidity and mortality. There are currently no effective antiviral agents for these pathogens. Studies reported herein attempt address this therapeutic shortfall through the testing of a panel of small molecule compounds and specifically designed small interfering RNAs (siRNAs) for antiviral effects against both viruses. Initial compound screening identified chloroquine, mefloquine, and hexamethylene amiloride as effective inhibitors of FCoV, whilst mefloquine effectively inhibited FCV. Efficacy at low micromolar concentration was confirmed with orthogonal testing, albeit with relatively narrow selective indices. Preliminary experiments performed to inform the antiviral mechanism of the compounds against FCoV demonstrated all three compounds acted at an early stage of viral replication. For FCV, mefloquine exhibited potent inhibition of a panel of recent field isolates and demonstrated additive effects in combination with recombinant feline interferon omega. For both FCoV and FCV, a number of siRNAs demonstrated potent and specific inhibition of viral replication. These were effective at low nanomolar concentrations, when used in combination, and against high viral loads. A structural siRNA variant, Dicer-substrate siRNA, demonstrated similar or better efficacy, depending on the target, over canonical siRNAs directed at the same FCoV motif. Limitations of antiviral siRNAs in terms of antiviral resistance were investigated. FCoV serially passaged through siRNA treated cells rapidly acquired resistance, however combination therapy with three siRNAs was able to delay this considerably. For FCV, siRNAs effective against the reference strain were broadly efficacious against field isolates, although some variability was noted. Taken together these results provide important information regarding potential antiviral therapies against these important pathogens.
7
Luz, Flávia Serena da. "Aspectos anatomopatológicos da medula óssea na peritonite infecciosa felina." Universidade Federal de Santa Maria, 2017. http://repositorio.ufsm.br/handle/1/11756.
Full textAbstract:
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESFeline infectious peritonitis (FIP) is a highly contagious, progressive and invariably fatal viral disease of cats, and occasionally of wild felids, which results from antibody-mediated hypersensitivity reactions (types III and IV) in individuals incapable to produce a cell-mediated immune response. Although the prevalence of FIP is high worldwide, recent anatomopathological studies about this disease are scarce. Furthermore, the microscopic characteristics of the bone marrow of FIP-affected cats do not exist in the available literature. Based on this, the purpose of this dissertation is to describe possible bone marrow lesions seen in spontaneous cases of FIP. Therefore, the bone marrow collected systematically from the femoral diaphysis of 16 cats necropsied in the LPV-UFSM (Santa Maria, RS, Brazil), between January 2000 and June 2017, with a definitive diagnosis of FIP, were evaluated phenotypically (histopathology [hematoxylin and eosin] and histochemistry [Perls reaction]) and immunophenotypically (immunohistochemistry using anti-myeloid [MAC387] and anti-lymphoid [CD79αcy and CD3] markers). The results showed, regardless of the clinicopathological form of the disease (“dry” [noneffusive] or “wet” [effusive]), myeloid hyperplasia; erythroid hipoplasia; megakaryocytic dysplasia (dismegakaryocytopoiesis); and medullary plasmacytosis. In cases of “dry FIP”, but not in those of “wet PIF”, there was bone marrow and hepatic hemosiderosis. These lesions allowed establishing that cats with FIP develop myelodysplasia, a myeloproliferative lesion very similar to that reported in HIV-infected humans. It is suggested that, based on the findings described here, myelodysplasia is considered to be the main cause of hematological abnormalities observed in FIP, especially for non-regenerative anemia and thrombocytopenia, frequently developed by patients.
Peritonite infecciosa felina (PIF) é uma doença marcadamente contagiosa, progressiva e invariavelmente fatal de gatos, ocasionalmente de felideos selvagens, que decorre de uma reação de hipersensibilidade (tipos III e IV) em um indivíduo incapaz de montar uma resposta imune celular adequada. Apesar da prevalência da peritonite infecciosa felina (PIF) ser alta em praticamente o mundo todo, estudos anatomopatológicos recentes acerca dessa doença são escassos. Não obstante, as características microscópicas da medula óssea de gatos com PIF inexistem na literatura consultada. Com base nisso, o objetivo deste estudo é descrever possíveis alterações medulares ósseas vistas em casos espontâneos de PIF. Para isso, as medulas ósseas colhidas sistematicamente da região diafisária dos fêmures de 16 gatos necropsiados no LPV-UFSM (Santa Maria, RS, Brasil), entre janeiro de 2000 e junho de 2017, e que tiveram diagnóstico definitivo de PIF, foram avaliadas fenotípica (histopatologia [hematoxilina e eosina] e histoquímica [reação de Perls]) e imunofenotipicamente (imuno-histoquímica utilizando marcadores anti-mieloide (MAC387) e anti-linfoide (CD79 αcy e CD3). Os resultados permitem afirmar que, independentemente da apresentação clinicopatológica da doença (seca ou úmida), ocorre: 1) hiperplasia mieloide; 2) hipoplasia eritroide, 3) displasia megacariocítica (dismegacariocitopoiese) e 4) plasmocitose medular. Nos casos de PIF seca, mas não naqueles de PIF úmida, há hemossiderose medular óssea e hepática. Essas alterações permitem estabelecer que gatos com PIF desenvolvem mielodisplasia, uma lesão mieloproliferativa muito semelhante àquela relatada em humanos infectados pelo HIV. Sugere-se que a partir dos achados aqui descritos, mielodisplasia seja considerada a principal responsável pelas alterações hematológicas observadas na PIF, especialmente pela anemia e trombocitopenia arregenerativas tão frequentemente desenvolvidas pelos pacientes com essa doença.
8
Gunn-Moore, Danielle Audry. "Molecualar characterisation of feline coronavirus infection." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390379.
Full text
9
Parreira, Maria Manuel Manteiga Carvalho Roma. "Diagnóstico laboratorial em animais de companhia." Master's thesis, Universidade de Évora, 2022. http://hdl.handle.net/10174/31366.
Full textAbstract:
O presente relatório foi realizado no âmbito do estágio curricular do Mestrado Integrado em Medicina Veterinária da Universidade de Évora, encontrando-se dividido em três partes. A primeira parte corresponde à análise da casuística acompanhada durante o estágio curricular, realizado no Laboratório Veterinário INNO, entre seis de outubro de 2020 e 26 de março de 2021. A segunda parte consiste numa revisão bibliográfica sobre a Peritonite Infeciosa Felina (PIF), uma doença infeciosa, inflamatória e imunomediada. Por fim, a terceira parte apresenta um estudo retrospetivo acerca da contribuição do rácio A/G e ΔTCN das efusões cavitárias para o diagnóstico de PIF. Apesar de não existirem caraterísticas bioquímicas e celulares nas efusões que permitam o diagnóstico definitivo da PIF, os resultados do estudo permitiram averiguar que este torna-se mais provável quando as efusões apresentam rácio A/G inferior a 0,88 e ΔTCN superior a 4,9; Abstract:
Laboratorial Diagnosis in Companion Animals
The present report refers to the internship for the completion of the Master Degree in Veterinary Medicine of the University of Évora, and is divided in three parts. The first part includes a statistical description of the followed procedures during the curricular internship, which was held at Laboratório Veterinário INNO, between October of 2020 and March of 2021. The second part consists of a bibliographic review on Feline Infectious Peritonitis (FIP), an infectious, inflammatory and immunomediated disease. Finally, the third part presents a retrospective study about the contribution of the A/G and ΔTCNN ratio of cavitary effusions to the diagnosis of FIP. Although there are no biochemical and cellular characteristics in effusions that allow the definitive diagnosis of PIF, the results of the study allowed to verify that it becomes more likely when effusions have an A/G ratio of less than 0,88 and ΔTCN greater than 4,9.
10
MEAZZI, SARA. "THE INTERPLAY BETWEEN HOST DEFENSES AND SYSTEMIC PATHOGENS IN PROMOTING DISEASES OF COMPANION ANIMALS." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/709076.
Full textAbstract:
Il microbiota intestinale (insieme dei microrganismi che si trovano all’interno dell’apparato gastroenterico) svolge diverse funzioni e, tra queste, di particolare interesse è il suo rapporto con il sistema immunitario. Infatti, diversi studi hanno evidenziato la presenza di disbiosi non solo in corso di patologie gastroenteriche, ma anche autoimmuni ed infettive. Gli studi in medicina veterinaria sull’argomento sono ancora pochi e proprio per questo motivo, all’interno di questo progetto, è stato scelto di indagare la possibile relazione tra il microbiota intestinale e due particolari patologie infettive (la peritonite infettiva felina -FIP- e la leishmaniosi canina) la cui patogenesi è fortemente influenzata dal tipo di risposta immunitaria sviluppata dall’ospite. Gli scopi di questo progetto sono quindi stati: la valutazione del microbiota intestinale in gatti affetti o meno da FIP (studio I). Dal momento che diagnosi in vivo di FIP risulta spesso difficoltosa, è stato valutato il potenziale, come biomarker di FIP, della paraoxonasi-1, una proteina di fase acuta negativa fortemente influenzata da importanti stati ossidativi (studi II e III). Per lo stesso motivo è stata valutata la correlazione tra le performance diagnostiche di istopatologia, immunoistochimica e RT-PCR su differenti organi (studio IV). Infine, è stata indagata la composizione del microbiota intestinale in cani infetti o meno da Leishmania spp., correlando i risultati ottenuti con le differenti popolazioni leucocitarie valutate mediante citofluorimetria (studi V e VI). I risultati ottenuti da questo progetto hanno fornito delle indicazioni preliminari sulla composizione del microbiota intestinale in gatti affetti da FIP o positivi per Coronavirus, che necessitano però un approfondimento su un gruppo di studio più ampio (studio I). È stato possibile determinare gli intervalli di riferimento della paraoxonasi-1 nel gatto ed evidenziare le sue buone performance come marker diagnostico in corso di FIP (studi II e III). Nonostante l’immunoistochimica rimanga il gold standard per la diagnosi di FIP, l’associazione con RT-PCR potrebbe ridurre gli errori diagnostici, vista la buona correlazione tra le due metodiche (studio IV). Infine, la valutazione della composizione del microbiota e delle popolazioni leucocitarie in cani affetti da leishmaniosi ha messo in luce delle differenze significative sia rispetto ai cani sani, che agli esposti asintomatici. Questi risultati sono incoraggianti e possono fungere da punto di partenza per ulteriori indagini (studi V e VI).The gut microbiota (consortium of all the microorganisms that inhabit the gastrointestinal tract) plays different roles in the host. Among these, its relationship with the immune system has been of great interest in the last few years. Indeed, several studies highlight the presence of dysbiosis not only in gastrointestinal diseases, but also during autoimmune or infectious diseases. Literature about this topic is scarce in veterinary medicine. Thus, in this project, the possible relationship between gut microbiota and two specific diseases (feline infectious peritonis -FIP- and canine leishmaniasis) was investigated. These diseases were chosen due to the pivotal role of the immune response in their pathogenesis. The aims of this projects were: the evaluation of gut microbiota of cats with and without FIP (study I). Since in vivo diagnosis of FIP is quite challenging, the potential role of paroxonase-1 (a negative acute phase protein strongly influenced by oxidation) as a biomarker of FIP was investigated (studies II-III). For the same reason, the diagnostic agreement among histopathology, immunohistochemistry and RT-PCR on different organs was evaluated (study IV). Finally, the gut microbiota composition in dogs infected or not by Leishmania spp. was investigated. The results were correlated with the leukocyte populations studied by flow cytometry (studies V-VI). Results obtained in this project provided preliminary data about gut microbiota composition in cats affected by FIP or only Coronavirus positive. This achievement needs to be further investigated on a bigger sample size (study I). Paraoxonase-1 reference interval and its good performance as a diagnostic biomarker of FIP were determined (studies II-III). Despite the immunohistochemistry is still the gold standard for FIP diagnosis, the good diagnostic agreement obtained in the study suggested that a possible association with RT-PCR could minimize diagnostic errors (study IV). Finally, the gut microbiota composition and leukocyte populations of leishmaniotic dogs highlighted some significant differences compared with both healthy and exposed asymptomatic dogs. These promising results could be a starting point for further researches (studies V-VI).
Books on the topic "Feline infectious peritoniti"
1
Nicholas, Kim Alan. Serum antibody responses in cats experimentally infected with feline infectious peritonitis virus. 1985.
Find full text
2
The Man in the Cat-Hair Suit: And other true stories. Chapel Hill, NC, USA: William R. Greene, 2011.
Find full text
3
The Man in the Cat-Hair Suit: And other true stories. Chapel Hill, NC, USA: William R. Greene, 2011.
Find full text
4
The Man in the Cat-Hair Suit: And other true stories. Chapel Hill, NC, USA: William R. Greene, 2011.
Find full text
5
The Man in the Cat-Hair Suit: And other true stories. Chapel Hill, NC, USA: William R. Greene, 2011.
Find full textBook chapters on the topic "Feline infectious peritoniti"
1
de Groot, Raoul J., and Marian C. Horzinek. "Feline Infectious Peritonitis." In The Coronaviridae, 293–315. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4899-1531-3_14.
Full text
2
Schmeltzer, Linda E. "Feline Infectious Peritonitis." In Nursing the Feline Patient, 185–88. Ames, Iowa, USA: John Wiley & Sons, Inc, 2016. http://dx.doi.org/10.1002/9781119264910.ch25.
Full text
3
Ishida, Takuo, Kazushige Toriyabe, Jun Fukuoka, and Shigekatsu Motoyoshi. "Serodiagnosis of Feline Infectious Peritonitis." In Coronaviruses, 577–78. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-1280-2_73.
Full text
4
Gershwin, Laurel J. "Case 30: Feline Infectious Peritonitis." In Case Studies in Veterinary Immunology, 145–49. New York, NY : Garland Science, [2017]: Garland Science, 2017. http://dx.doi.org/10.4324/9781315165462-30.
Full text
5
Mehrbod, Parvaneh, Mohammad Syamsul Reza Harun, Ahmad Naqib Shuid, and Abdul Rahman Omar. "Transcriptome Analysis of Feline Infectious Peritonitis Virus Infection." In Coronaviruses, 241–50. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2438-7_20.
Full text
6
Pedersen, Niels C. "Virologic and Immunologic Aspects of Feline Infectious Peritonitis Virus Infection." In Coronaviruses, 529–50. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-1280-2_69.
Full text
7
Soma, Takehisa. "Feline Coronavirus RT-PCR Assays for Feline Infectious Peritonitis Diagnosis." In Springer Protocols Handbooks, 161–70. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3414-0_15.
Full text
8
McArdle, F., M. Bennett, R. M. Gaskell, B. Tennant, D. F. Kelly, and C. J. Gaskell. "Canine Coronavirus Infection in Cats; A Possible Role in Feline Infectious Peritonitis." In Advances in Experimental Medicine and Biology, 475–79. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4684-5823-7_66.
Full text
9
Gerber, J. D., N. E. Pfeiffer, J. D. Ingersoll, K. K. Christianson, R. M. Landon, N. L. Selzer, and W. H. Beckenhauer. "Characterization of an Attenuated Temperature Sensitive Feline Infectious Peritonitis Vaccine Virus." In Advances in Experimental Medicine and Biology, 481–89. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4684-5823-7_67.
Full text
10
Vennema, Harry, Raoul J. de Groot, David A. Harbour, Mieke Dalderup, Tim Gruffydd-Jones, Marian C. Horzinek, and Willy J. M. Spaan. "Immunogenicity of Recombinant Feline Infectious Peritonitis Virus Spike Protein in Mice and Kittens." In Advances in Experimental Medicine and Biology, 217–22. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4684-5823-7_30.
Full textConference papers on the topic "Feline infectious peritoniti"
1
Jähne, S., S. Felten, K. Matiasek, M. Bergmann, C. Leutenegger, and K. Hartmann. "Detection of mutated and non-mutated feline coronaviruses in cats without feline infectious peritonitis." In 29. Jahrestagung der FG „Innere Medizin und klinische Labordiagnostik“ der DVG (InnLab) – Teil 1: Vorträge. Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0040-1722399.
Full text