Dissertations / Theses on the topic 'Features of significance'
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Schuy, Lars. "Speech features and their significance in speaker recognition." Thesis, University of Sussex, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288845.
Full textBrown, Sandra Lois School of Design UNSW. "Significance, the vessel and the domestic." Awarded by:University of New South Wales. School of Design, 2004. http://handle.unsw.edu.au/1959.4/20761.
Full textGerakis, J. G. (Jeffrey George). "Aerodynamic measurements on some special wing features of nocturnal owls and their acoustic significance." Thesis, McGill University, 1985. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=63333.
Full textChan, Yuen Ling (Tracey). "The biological features and clinical significance of natural killer cell reconstitution following allogenic stem cell transplantation." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8714/.
Full textStyles, Adam James. "The nature and significance of Late-Orogenic extensional structures in the Varsican Orogen of SW England and comparison to equivalent features from the Italian Apennines." Thesis, Durham University, 1997. http://etheses.dur.ac.uk/981/.
Full textWhissell, John. "Significant Feature Clustering." Thesis, University of Waterloo, 2006. http://hdl.handle.net/10012/2926.
Full textPerkins, David Neil. "Computer methods for identifying significant features in protein sequences." Thesis, University of Leeds, 1994. http://etheses.whiterose.ac.uk/6772/.
Full textChang, Raphael M. Eng Massachusetts Institute of Technology. "Significance of omnidirectional fisheye cameras for feature-based visual SLAM." Thesis, Massachusetts Institute of Technology, 2020. https://hdl.handle.net/1721.1/129885.
Full textCataloged from student-submitted PDF of thesis.
Includes bibliographical references (pages 117-124).
Robust GPS-denied navigation of mobile robots is becoming increasingly important as robots become more ubiquitous. Cameras are powerful sensors for this application due to their low cost and high information density. The task of using camera-based computer vision techniques for navigation is typically referred to as visual simultaneous localization and mapping (SLAM), where a robot both estimates its pose and reconstructs its environment simultaneously using only cameras. Most existing work for visual SLAM relies on the use of the pinhole camera model, which requires that images from wider angle, more distorted lenses be rectified before they are usable. This limits the field of view well below 180 degrees. However, cameras with omnidirectional fisheye lenses can see much more of their surroundings, which suggests they may be beneficial for the visual SLAM task; this hypothesis is supported by the trend that recent commercial products that rely on robust visual navigation use fisheye cameras. In this thesis, we explore the apparent discrepancy between the types of cameras traditionally used for navigation tasks in the research community and in industry where robustness is critical. We propose that the scarcity of work using omnidirectional cameras is due to an ill-formed belief that adapting fisheye lenses into traditional computer vision algorithms is infeasible or not worth the effort required to redesign those algorithms. To show this, a benchmarking suite for stereo visual SLAM was developed using traditional feature-based visual odometry algorithms. The building block components of visual SLAM, including feature correspondence, odometry, and reconstruction, were evaluated for both fisheye and perspective cameras. The results show that not only do omnidirectional fisheye cameras easily plug into existing algorithms with minimal modification, they also result in better performance for navigation tasks than perspective cameras with limited field of view.
by Raphael Chang.
M. Eng.
M.Eng. Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science
Chen, Li. "Searching for significant feature interaction from biological data." Diss., Online access via UMI:, 2007.
Find full textSreevalson, Nair Jaya. "Modular processing of two-dimensional significance map for efficient feature extraction." Thesis, Mississippi State : Mississippi State University, 2002. http://library.msstate.edu/etd/show.asp?etd=etd-07012002-111746.
Full textTreter, Christine W. "The significance of selected compositions by Ralph Vaughan Williams which feature the viola." Virtual Press, 1993. http://liblink.bsu.edu/uhtbin/catkey/861379.
Full textSchool of Music
Erande, Abhijit. "Automatic detection of significant features and event timeline construction from temporally tagged data." Kansas State University, 2009. http://hdl.handle.net/2097/1675.
Full textDepartment of Computing and Information Sciences
William H. Hsu
The goal of my project is to summarize large volumes of data and help users to visualize how events have unfolded over time. I address the problem of extracting overview terms from a time-tagged corpus of data and discuss some previous work conducted in this area. I use a statistical approach to automatically extract key terms, form groupings of related terms, and display the resultant groups on a timeline. I use a static corpus composed of news stories, as opposed to an on-line setting where continual additions to the corpus are being made. Terms are extracted using a Named Entity Recognizer, and importance of a term is determined using the [superscript]X[superscript]2 measure. My approach does not address the problem of associating time and date stamps with data, and is restricted to corpora that been explicitly tagged. The quality of results obtained is gauged subjectively and objectively by measuring the degree to which events known to exist in the corpus were identified by the system.
Pearson, John. "Indians, ungulates, and unconventional oil : the protection of culturally significant environmental features through multi-jurisdictional human rights law." Thesis, Lancaster University, 2013. http://eprints.lancs.ac.uk/62137/.
Full textRomeiro, Ricardo Augusto Guimarães. "Aprendizagem baseada em projetos na aplicação de gráficos de funções com apoio de recursos computacionais no Ensino Médio." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/97/97138/tde-29032017-095836/.
Full textThe Project Based Learning (PBL) is an active and systematic approach, where classes are student-centered and allows you to work individually and in groups by applying this method to solve problems. This project aims to attempt to improve the quality of education through the construction of functions using alternative computing resources as support for meaningful learning, assuming insert software in education, with the help of PHET simulator and software educational WINPLOT. The simulator will be used to create the necessary motivation to enter content and contribute to the student better understand the presence of mathematics in other disciplines such as physics and biology, the WINPLOT software will be used to build and graphics conferences and PHET simulator will be used to relate the content with everyday situations. This project will be applied to students of the 3rd year of high school, in a private institution of elementary education in the city of Lorena- SP. This work will be divided in seven stages, and these steps will be done in sequence and, for the assembly of each activity, the results presented in the previous activity will be analyzed.
Zavalina, Viktoriia. "Identifikace objektů v obraze." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2014. http://www.nusl.cz/ntk/nusl-220364.
Full textDušek, Stanislav. "Určení parametrů pohybu ze snímků kamery." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2009. http://www.nusl.cz/ntk/nusl-217782.
Full textGhadie, Mohamed A. "Analysis and Reconstruction of the Hematopoietic Stem Cell Differentiation Tree: A Linear Programming Approach for Gene Selection." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32048.
Full textDrochytka, Jan. "Vliv specifické lokality na cenu rezidenčního objektu na Brněnsku." Master's thesis, Vysoké učení technické v Brně. Ústav soudního inženýrství, 2020. http://www.nusl.cz/ntk/nusl-413826.
Full textMcgowan, Eileen Marie. "Significance of Water-Related Features on Mars." 2010. https://scholarworks.umass.edu/open_access_dissertations/208.
Full textMcgowan, Eileen M. "Significance of water -related features on Mars." 2010. https://scholarworks.umass.edu/dissertations/AAI3409820.
Full textIdika, Odum. "A preliminary investigation into the ecological significance of headwater drainage features in Southern Ontario." Thesis, 2010. http://hdl.handle.net/10012/5236.
Full textShie, Ya-Shing, and 謝雅欣. "The Features and Significance of Taiwanese Street Dancers' Clothing Styles : A Multiple Case Study." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/81379789411687515370.
Full text國立嘉義大學
視覺藝術研究所
95
Street dance has become a popular Taiwanese youth culture in recent years, representing a diversified vusul code. Derived from the subculture of African Americans, street dance was created by African Americans and transferred to and localized in Taiwan, resulting in a brand new form. Taiwanese street dancers’ common clothing models have become one of the visual codes that characterize contemporary Taiwanese visual culture. However, relatively little research attention seems to have been devoted to the feature and significance of street dance clothing in Taiwan. Thus, this study aims to recognize features of Taiwanese street dancers’ clothing styles and understand the significance of Taiwanese street dancers’ clothing style revealed in individual cases. The research methods include those of semiotics and multiple case study. The data are drawn via on-site observation, photos and pictures gathering, and in-depth interviewing. The data on street dancer clothing styles and multiple case styles are analyzed in light of paradigm. The findings are: (1) loose garments are no longer the only choice, and fashionable pluralistic styles have become the current trend; (2) female dancers’ clothing styles are more pluralistic than male, but the styles of both are mainly for catching attention; (3) through some media the dancers look for clothing reference materials, whether creative or reproductive; and (4) the significance of the dancers’ clothing styles is constructed according to their own understanding of street dance clothing styles. By reproducing elements of American hip-hop clothing, and blending into their own clothing the code of fashion, Taiwanese street dancers have created the features and significance of their own clothing styles in accordance with their own personality and experience.
Hong-Fang, Song, and 宋宏方. "The Significance of Prostaglandin E Receptors in the Pathogenesis of Renal Cell Carcinoma with Rhabdoid Features." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/ypn3n3.
Full text國立成功大學
分子醫學研究所
104
Renal cell carcinoma (RCC) arises from proximal convoluted tubules and is the most common type of kidney cancer. The common histologic subtypes include clear cell RCC (ccRCC, 70-75%), papillary RCC (16%), chromophobe RCC (7%), translocation carcinoma (1%), collecting duct carcinoma (〈0.5%), and renal medullary carcinoma (〈0.5%). Malignant rhabdoid tumor is a rare and aggressive malignant tumor that mostly occurs in the kidney and brain of infants and young children. The important pathogenic mechanism of this entity is truncating mutation of a tumor suppressor gene- Integrase interactor 1 (INI1/hSNF5) gene. The INI1, core member of BAF (hSWI/SNF) complex, is an ATP-dependent chromatin-remodeling complex and plays an essential role in multiple nuclear processes, such as transcription, DNA replication and repair and negative regulator of cell cycle. In addition, the SWI/SNF remodeling complex also involves in cell proliferation, differentiation, antiviral activity, and inhibition of tumor formation. RCC with rhabdoid features (RCC-RF) occur in around 3% to 7% of RCC and is associated with a poor prognosis. However, its pathogenesis remains elusive. Analysis of paired tumor and non-neoplastic kidney specimens (n = 5) revealed down-regulation of INI1 at both transcriptional and translational levels. A total of 8 cases (age ranged from 48 to 79) were retrieved from archive and analyzed for INI1 immunohistochemistry and clinical outcome. Loss of nuclear INI1 expression was demonstrated in the rhabdoid cells in all 8 cases compared with adjacent ccRCC. The interval between diagnosis and metastasis ranged from 3 to 43 months. Four of them died of cancer and one patient is alive with progressive disease despite of treatment with targeted therapies. To identify molecular pathogenesis of RCC-RF, an INI1 stable knock-down cell line was established from ACHN ccRCC. Suppression of INI1 was significantly associated with rhabdoid changes, enhanced cell proliferation, up-regulated EGFR, and VEGF expression/secretion in vitro. However, only Everolimus and Erlotinib were effective in suppression the growth of INI1 stable knock-down cell line, whereas treatment with VEGFR inhibitors (sorafenib or sunitinib) did not inhibit the growth of tumor cells. To identify potential co-targeting molecules, EP family, which receives PGE2 signal, was chosen from microarray profiling for investigation because of its involvement in VEGF-C-mediated pulmonary carcinogenesis and a crosstalk with EGFR. RT-PCR screening revealed an up-regulated EP1 and EP4 in ACHN INI1 knock-down stable cells compared with control. We also demonstrated that PGE2 synthase-COX1 is up-regulated by knocking down the INI1. Erlotinib (EGFR inhibitor) effectively inhibited the growth of ACHN INI1 knock-down cells compared with vector control; whereas Gefitinib had no inhibitory effect. The Everolimus (mTOR inhibitor) also inhibited the growth of ACHN INI1 knock-down cells. Both Everolimus and EGFR inhibitors (Erlotinib and Gefitinib) effectively suppressed the growth of ACHN INI1 and EP1 double knockdown cells. Using this model experiment, a cocktail of PGE2/EP1 pathway inhibitor together with Everolimus and EGFR inhibitor (Erlotinib or Gefitinib) is preferred for patients with RCC-RF.
Campelo, Filipe José Valente. "Climatic significance of tree-ring width and intra-annual wood features in Pinus pinea L. and Quercus ilex L." Doctoral thesis, 2008. http://hdl.handle.net/10316/9678.
Full textYuan, Tein-Ming, and 袁天民. "The Prognostic Significance of Clinical Features and Immunohistochemical Characterization of the Recurrence in the Resected Advanced Gastrointestinal Stromal Tumors." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/87877006591404740838.
Full text國立中興大學
生命科學院碩士在職專班
96
Gastrointestinal stromal tumors (GISTs) are the most malignant mesenchymal tumor in the gastrointestinal (GI) tract. Palpable abdominal mass and acute abdomen pain are the major common symptoms in the GISTs. Most of GISTs were detected in the stomach. The tumor size and mitosis counts are the most important factors to predict the prognosis and to define the risk categories. The GISTs are poor responder to chemotherapy and radiotherapy and the only cure method is surgical resection for the primary GISTs in time. Recently, a target therapy using imatinib had a promising reponse rate. However, in some GISTs mutation in constitutively activated C-kit gene mutation (CD 117) and platelet-derived growth factor receptor alpha (PDGFR-α), which are the major therapeutic target for imatinib mesylate (Gliveec), are frequently identified. However, the clinical significance of these factors in GIST is not well characterized in this study. We therefore analyzed the clinicopatholical factors to evaluate the role of these factors in the the recurrence and metastasis of the primary resected GIST. Between August 2001 and March 2006, 31 advanced GIST patient’s paraffin embedded specimens were collected Immunohistochemical staining of CD-117, SMA, CD-34, S-100, Desmin, Bcl-2, PDGFR-α were performed in these specimens. Patients were classified on the basis of tumor size, the mitotic rate and CD117 positively. Advanced GISTs were defined as intermediate (I) and high risk (II) group. To evaluate what prognostic factors influences tumor recurrence and metastasis after resection of advanced gastrointestinal stromal tumors. Results revealed that age (p=0.048) and tumor recurrence (p=0.036) had significant differences between (I) and (II) group. The intermediated risk group had longer disease free time than high risk group (27 months Vs 17.5 months). It is evidence that high risk group GISTs were belong to poor disease free survival (p=0.047). Between the tumor recurrence group and non-recurrence group, there were significant differences in sex (p=0.013), incomplete resection (p=0.035), and Bcl-2 (p=0.046). Otherwise, most factors ( including age, clinical signs and symptoms, tumor location, immunochemical stains and PDGFR-α) had no significant differences in the recurrence group. PDGFR-α expression (29%) also was noted in the CD 117 overexpression specimens and no significant influence in disease progression. No mortality case was found in the advanced GISTs treated with imatinib. In conclusion, the results from this study that male, resection margin and Bcl-2 are predictive factors for GISTs tumor recurrence. Meanwhile, the GIST risk classification not only has the help to forecast the GIST progression also to be able effectively to forecast the GIST recurrence.
Chang, Jun-Chieh, and 張潤杰. "A Study of Applying Image Significant Features to Robust Watermarking Techniques." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/793td3.
Full text臺中技術學院
資訊工程系碩士班
99
Nowadays, our life is full of the digital technologies, and the digital watermarking has been used for copyright protection widely. The methods of digital watermarking technique are to embed the specific signal in the host media that we want to protect. The media could be video, voice or image…etc. In extraction procedure, users use the algorithm which same as what provider embedded in to extract the watermark information. Therefore, users can prove the legal ownership by utilizing the watermark information. To achieve workable copyright protection, have to keep the embedded algorithm robust enough. That is, users can still extract the watermark information to provide the legal ownership even the media had been attacked or affected under any circumstance. This thesis presents two robust watermarking schemes in the spatial domain and transform domain according to the image signification features. In Chapter 3, a robust watermarking scheme that resisting geometric attack is proposed. The major method uses the corner detection to find the important edge features from the host protected image. These edge features usually are more robust and not being damaged easily. Therefore, the location information of edge features still can be recovered even the image has been rotated, scaled, and geometric attacked. Since these edge features are selected by corner detection, the embedded information can still be extracted under the geometric attack. Since these edge features are selected by corner detection, the embedded information can still be extracted under the geometric attack. In Chapter 4, an effective robust watermarking scheme which based on singular value decomposition (SVD) and particle swarm optimization (PSO) is proposed. The core idea aims at the transform domain method which is the singular value decomposition. The SVD can extract important feature of protected image and then we use PSO algorithm to modify the singular values for embedding. Because the singular value matrix of SVD remains unchanged via translation attack, transpose attack, rotation attack, and the proposed watermarking technique is robust based on the properties of SVD. Finally, we clearly demonstrate that the watermarking technique to against attacks is workable. Besides, does not need to record the extra information because of the quantization method.
Huang, Yu-Hsiang, and 黃昱翔. "The Significance of Maintenance: the Social and Technological Feature of Residential Green Building." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/7shnx2.
Full text國立臺灣大學
地理環境資源學研究所
104
This paper aims to illuminate both the difficulty of and the key point to building maintenance in the practice field of residential green building in Taiwan, and this paper treats the maintenance of the green building system as a process in which society, technique and users interweave with one another. The social factor points to the policies and the laws concerning building construction, the residential spaces and the features of commodities. It affects the usage of green building construction technology, the normative regulation for building constructors, and the mechanism of building maintenance among dwellers. The technical factor refers to the technical features of variegated green technology, which not only should be responsive to the policies, but also has an effect on the actors, including how the companies design and construct buildings, and dwellers’ agency. The concepts of Interpretive Flexibility from Social Construction of technology Theory (SCOT) and boundary object from Social World Theory shed us a new light to understand how buildings maintenance is possible under the intertwining factors. In practical world, the disputes over technology—the faults produced in the process of design or construction, the unpredictability of the technology—will keep emerging such that implementing new technology seems impossible. Fortunately, the case of H Building Company is a silver lining, proffering another alternative. After finishing the construction, H Building Company keeps highly involved in how dwellers’ maintain their building, and re-identifies technological problems, resulting in dwellers’ gestalt switch on the cognition of technology—that green building technology is now an issue of sustaining a symbiotic relationship with nature in an ecosystem but no longer mere the concept in architectural landscape. As a result, caterpillars, algae, aphids and mosquitos which were once claimed potential threat to technology are now used as a means to justify the indispensability of upgrading new technology on the one hand, and to prove the success of the gestalt switch on the cognition of technology on the other hand, enabling the green technology carried out as H Building Company originally planned.
Lin, Ching-Hsiu, and 林敬修. "The Evaluation of the Significant Features of Hepatocellular Carcinoma for Precontrast CT Liver Images." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/468zj2.
Full text義守大學
資訊工程學系
106
Due to the low index of renal function who after use contrast media probability lead to acute kidney failure, and only by precontrast CT difficult to diagnose all diseases. And in physical examination CT items to the most are without contrast media. This study hopes to provide a reference for predicting HCC without increasing the physical burden. This study is a retrospective study design, a total of 101 cases of CT triphase examinations reported by radiologists are expected to be collected from December 2016 to June 2017.Among them, those who did not find significant abnormalities and benign lesions were classified as control group, a total of 56 cases; and the radiologist completed the report of suspected HCC as experimental group, a total of 45 cases. Then we will using multi-seed region growing to obtain the features of precontrast CT liver images, and the statistical analysis of the intra-area image characteristics was calculated to establish a model for predicting the occurrence of HCC. For descriptive statistics, the mean value in the experimental group was 138.84 HU, which was lower than the 141.74 HU of the control group, while the average age of the experimental group was 64.22 years, the AFP,GOT and GPT was 531.43 ng/ml,59.36 U/L and 53.04 U. /L, were higher than the average age of the control group 57.05 years old, AFP.GOT and GPT was 9ng/ml,32.43U/L and 33.19U/L, P<0.05 is a significant feature of HCC. Cross-table comparisons found that the chance of male rickets in this study was 1.88 times that of women. In the univariate logistic regression, the significant features of HCC were the mean value, age, AFP,GOT and GPT (P<0.05). Finally, using the multivariate logistic regression to establish the prediction model, and then use the ROC curve to verify ,and the AUC can reach 0.899. When the cut-off point is 0.526, it has a true positive rate of 80.5% and a clearness of 88.6%. It has a very high accuracy, and the Kappa also has a consistency of 0.657. The significant features of HCC are the mean value, age, AFP, GOT, and GPT. The predictive model shows high probability of HCC, as lower mean value, older, higher AFP, GOT and GPT. Then, further inspections are needed to exam the situation of body. In the future, we hope to analyze the liver texture to improve the capture of the whole liver area.
Hsueh, Shih-Hua, and 薛詩樺. "A Study of Building a Specific Image Database Based on Significant Color and Texture Features." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/5t6b5m.
Full text國立臺中科技大學
資訊管理系碩士班
100
In this thesis, the main issue is to build a specific database for different web image search engines. The searching result images contain the true images, drawing images, sometimes contemporary images exist in search results. To solve this problem, two simple color features and a texture feature are proposed to build image databases. First, building a specific database scheme to use quantization-color-size histogram is proposed in Chapter 3. The proposed method first removes the smaller size and clipart images from the return images, and then it uses color quantization and calculates the sum of continuous intervals from the quantization-color-size histogram to get the global color feature. If an image is conformed to the global feature then it can be saved in the database. As a result, the proposed method has the high accuracy and effectively filters the web-searching results to form the desired image database.In Chapter 4, a simple color feature to obtain the global feature for building the specific image database with more accuracy is proposed. First, accumulate histogram of quantized colors for each block, and find the maximum of quantization colors of each block. Next, accumulate and find the larger accumulations of quantized colors in an image. Finally, the proposed method counts the frequency of these quantized for all search images and obtain the global color feature. From experimental results, the proposed method has high accuracy for the specific database for the web search engine.In Chapter 5, an angle texture feature is proposed to build a specific texture database for web image search engine. After removing the clipart images, the proposed method uses angle direction variation to build each angle co-occurrence matrix. The next step is to find the top 11 elements of the co-occurrence matrix as the angle feature, and the indices of corresponding columns and rows are extracted to be representative patterns. Finally, for all search images, count the pattern numbers for each angle feature and find the patterns of the each angle feature where the amount is larger than 70%. From experimental result, the proposed method has high accuracy of larger than 94% to build a specific database for the web search engine.
Mu, Yang-Ming, and 穆陽明. "To explore whether the IFRS features and information system performance have a significant impact on achieving IFRS financial reporting task." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/ar57vx.
Full text國立中央大學
企業管理學系在職專班
105
To attract foreign investment for investing domestic enterprises and reducing the cost of preparation of relevant international statements, Taiwan's listed and over-the-counter companies and financial management of the financial industry in 2013 formally adopted IFRS to prepare financial statements instead of ROC GAAP. Introducing IFRS has had a comprehensive impact on the enterprise. Thus, the purpose of this study is to explore whether the information system performance and IFRS features have a significant impact on achieving IFRS financial reporting task after IFRS was introduced. This study collected research data through a questionnaire distributed in 2015. The participants were composed of companies that adopted the IFRS and covered in the fields of Taiwan’s listed, over-the-counter, and emerging stock markets. SmartPLS 3.0 was used as the analysis tool. In this way, the study can explore the relationships among information system performance, IFRS features, as well as IFRS financial reporting task. The empirical results show that the performance of the information system is not significantly related to the IFRS financial reporting task. However, some of the mediators in the IFRS accounting process have significant influence on the IFRS financial reporting task. It can be learned that in order to achieve the goal of IFRS financial reporting task, the information system upgrade cannot be the only thing to rely on. It is crucial to make the appropriate adjustment and response in terms of IFRS features so that the objectives of IFRS financial reporting can be improved and achieved.
Chuang, Han-Yu, and 莊涵宇. "An Objective-Oriented aspect of Feature Selection for Optimal Experimental Designs and Detection of Significant Genes on Microarray." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/64828530039483774412.
Full text國立臺灣大學
資訊工程學研究所
91
For science, engineering, and bioinformatics, feature selection are found in all machine learning tasks, including pattern recognition and time-series prediction. This thesis proposes a new approach named objective-oriented (ObO) approach of feature selection and presents several related applications for microarray analysis, categorized optimal experimental design and detection of significant genes. With the frame of ObO, the objectives of feature selection are two classes: 1) ranking features individually with ability to provide a better realization of the underlying concept that generates the data, and 2) combining a set of features to derive the best possible prediction performance of the target learning algorithm. For the first objective, ObO uses “Data Fusion” techniques to rank features by their capability of interpreting the aimed knowledge. For the second one, Obo uses evolutionary approaches to acquire optimal sets of features with the best performance for the target. ObO has produced promising results in these bioinformatics problems on microarray. For optimal experimental design problem, we demonstrate that the evolutionary approach of ObO is promising for several kinds of experimental objectives: 1) comparisons between all pairs of treatments of equal interest; 2) comparisons between some pairs of treatments of greatest interest. The experimental results indicate that the proposed method can find all the optima for tested problems. For the problems of detection of significant genes, we derive three methods. Two of them are based on data fusion techniques of ObO to rank genes using expression levels for relevance of given experimental conditions, and the other one uses the evolutionary approach of ObO to search the optimal gene sets with small size and the best discriminability between samples. The experimental results show these methods based on ObO are competitive with commonly used feature selection methods and provide more general solutions.