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Dissertations / Theses on the topic 'FC'

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Published: 4 June 2021

Last updated: 18 May 2024

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1

Smith, Claude David. "Development of a maintenance advisor expert system for the MK 92 MOD 2 Fire Control System : FC-1 Designation - Time, Range, Bearing, FC-1 Acquisition, FC-1 Track - Range, Bearing, and FC-2 Designation - Time, Range, Bearing, FC-2 Acquisition, FC-2 Track." Thesis, Monterey, California. Naval Postgraduate School, 1993. http://hdl.handle.net/10945/40000.

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Approved for public release; distribution is unlimited.
The MK 92 MOD 2 Fire Control System is a complex weapons system based on 1970's technology. It is a maintenance intensive system, requiring extensive technical trouble-shooting and, occasionally, supplemental shore based support. Development of an expert maintenance system for the MK 92 MOD 2 Fire Control System offers a viable solution to the labor intensive efforts of the technicians, reduces the number of Visits by shore based support staff, and provides relief to an already overburdened maintenance budget. It will also significantly reduce the depot repair 'no fault evident' rate which is the result of good parts replaced because of defective trouble shooting. This thesis addresses the first iteration of prototype development of the performance channels of the MK 92 MOD 2 Maintenance Advisor Expert System. Specific issues covered include the scope of the project, hardware selection, system shell selection, knowledge acquisition, knowledge representation, knowledge implementation, and lessons learned in the process.

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2

Zhang, Gaiping. "Bovine IgG Fc receptors." Thesis, University of Hertfordshire, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387187.

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3

Čížek, Ondřej. "Podnikatelská strategie FC Insolvence." Master's thesis, Vysoká škola ekonomická v Praze, 2014. http://www.nusl.cz/ntk/nusl-193298.

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Tato diplomová práce se soustředí na podnikatelský projekt a klade si za cíl zjistit, zda je popisovaný záměr dlouhodobě konkurenceschopný a ziskový. K dosažení zadaného cíle budu postupně používat vhodné analýzy, které budu následně vyhodnocovat a prezentovat. Tyto a samozřejmě i jiné nástroje využívané v práci budou sloužit k získávání kvalitních dat a jejich následné třídění bude přispívat k zjištění cíle uvedeného na začátku. Sekundárním cílem je vytvořit strategii společnosti na základě získání dat o konkurenci, trhu, zákaznících a dalších. Použité metody budou mít teoretické ukotvení v příslušných kapitolách práce. Prezentaci výsledků společně s hodnocením a mými názory najdete v závěru práce.

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4

Janssen-Graalfs, Iska. "Charakterisierung des murinen Fc[gamma]RII [Fc-gamma-RII] bei Entzündung und Autoimmunität." [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=960596771.

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5

Sowa, Eveline. "Untersuchung der Expression verschiedener Fc[gamma]-Rezeptoren [Fc-gamma-Rezeptoren] in glomerulären Mesangiumzellen der Maus sowie deren Funktion in vitro mit Hilfe von Fc[gamma]RIII-Defektmutanten [Fc-gamma-RIII-Defektmutanten]." [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=960916644.

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6

Al-Khabbaz, Hana J. "The Role of the Neonatal FC Receptor (FCRN) in the Transfer of Passive Immunity and Maintenance of Active Autoimmunity." Fogler Library, University of Maine, 2008. http://www.library.umaine.edu/theses/pdf/AlkhabbazH2008.pdf.

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7

Jaroš, Luboš. "Ekonomika FC Vysočina Jihlava, a.s." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2009. http://www.nusl.cz/ntk/nusl-222165.

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The thesis analyses the current economic position of the football club FC Vysočina Jihlava, a.s. (joint-stock company), including the analysis of motives and conditions for the sponsorship of the club. The primary task of this thesis was to create a theoretical description of the points at issue of marketing (or marketing mix) and financial analysis and consequentially their practical use for the appraisal of general economic position of the football club FC Vysočina Jihlava, a.s. in the period 2005-2007.

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8

Drescher, Bettina. "Effekt der Glycosylierung von CD16 (Fc[gamma]RIII) [(Fc-gamma-RIII)] auf das IgG-Bindungsverhalten." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963204076.

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9

Hashmi, Syed Mushahid Hussain. "Cooling Strategies for PEM FC Stacks." Hamburg Helmut-Schmidt-Universität, Bibliothek, 2010. http://d-nb.info/1001185463/34.

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10

Baruah, Kavitha. "Structural biology of IgG Fc glycoforms." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:def683d3-aa06-41d9-9f28-29d21258bebe.

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The conserved N-linked glycosylation site on the Fc domain of IgG1 antibodies is essential for maintaining a functionally active conformation of the antibody. Different glycoforms of the Fc exhibit widely different effector functions. Similarly, therapeutic antibodies, with engineered glycosylation, exhibit altered binding to cellular Fc receptors (FcRs). Here, X-ray crystallographic structures were obtained for biosynthetic intermediate glycoforms of human IgG1 Fc bearing: unprocessed oligomannose-type, intermediate hybrid-type, and mature complex-type glycans. The fully processed Fc protein crystallised in an “open” conformation with glycans forming canonical stabilising interactions on the protein surface. Analysis of the biosynthetic intermediates revealed that these stabilising hydrophobic protein-glycan interactions are formed only after processing by Golgi -mannosidase II. Mutagenesis of hydrophobic residues on Fc disrupted crucial protein-glycan interactions resulting in the selective destabilization of the 3-arm of the glycan chain with the 6-arm closely matching that seen for the native structure. However, carbohydrate analysis of released glycans shows increased processing on both arms indicating a more accessible and flexible glycan in the mutant structure suggesting that the crystallographic structure of these antibody glycans represents a minor low-energy conformation. The importance of Fc glycosylation is highlighted by endoglycosidases which eliminate Fc effector function. The crystallographic structure of enzymatically deglycosylated IgG Fc revealed a significant collapse of the of Cγ2 domains resulting in a ‘closed’ quaternary conformation, incompatible with Fc receptor binding. This provides a structural explanation for immune deactivating properties of endoglycosidases including those under preclinical development for the treatment of antibody-mediated immune pathology. One such bacterial endoglycosidase, Endo S, was studied further and revealed a specificity for complex-type glycans of the type found on IgG but no hydrolytic activity towards an engineered IgG Fc with oligomannose-type glycans. Introduction of both the engineered monoclonal IgG and endoglycosidase in serum led to a dramatic increase in FcR binding as the competitive binding of serum IgG for FcRs was selectively eliminated. This approach is a general technique for boosting the effector signal of therapeutic antibodies.

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11

Nekvindová, Martina. "Ocenění fotbalového klubu FC Slovan Liberec." Master's thesis, Vysoká škola ekonomická v Praze, 2016. http://www.nusl.cz/ntk/nusl-264686.

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The aim of this thesis is to find a suitable approach for valuation of Czech football clubs and application of this approach for valuation of FC SLOVAN LIBEREC. The thesis examines specifics of football business and its effects on valuation. The market value of FC SLOVAN LIBEREC is determined as of 31. 12. 2015, based on strategic and financial analysis of the club.

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12

Benhamou, Marc. "Etude des recepteurs fc des mastocytes derives de la moelle osseuse de souris : modulation du fc::(e)r1 par la dexametasone, et caracterisation du fc::(g)r." Paris 7, 1988. http://www.theses.fr/1988PA077009.

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13

Schwemmler, Christopher [Verfasser]. "Antivirale Wirksamkeit des Fc-gekoppelten CAR-Like-Soluble-Proteins (CLSP-Fc) bei Coxsackie- und Adenovirusinfektionen / Christopher Schwemmler." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2013. http://d-nb.info/1043197087/34.

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14

Good, Samantha. "An investigation into the interaction of truncated recombinant IgE-Fc fragments with Fc&RI and CD23." Thesis, University of Sheffield, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274954.

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15

Lorenz, Anja, Annett Einert, and Barbara Dinter. "FC WInf: Flipped Classroom in der Wirtschaftsinformatik." Universitätsbibliothek Chemnitz, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-96870.

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Szenarien mit Blended-Learning-Charakter sind Alltag an deutschen Hochschulen: Insbesondere durch die Verbreitung von Learning-Management- Systemen, in Sachsen namentlich „OPAL“, können Lehrveranstaltungen über die Präsenzveranstaltungen hinaus in nahezu allen Fachbereichen um computergestützte Lerneinheiten ergänzt werden. Nach der Etablierung von Web Based Trainings als typische digitale Ergänzungsmodule streben einige didaktische Konzepte die verstärkte Abstimmung von Präsenz- und Onlinephase an. In der jüngeren Zeit wurde vor allem die Idee des Flipped Classroom (auch Inverted Classroom genannt) diskutiert. Hierbei wird die traditionelle Aufteilung der Lehr-Lern-Aktivitäten, bei der die Wissensvermittlung in den Präsenzveranstaltungen und die Vertiefung des Gelernten in Übungen zu Hause stattfinden, vertauscht. Stattdessen erwerben die Studierenden das nötige Wissen online und im Vorfeld der Präsenzphase, in der dann mithilfe komplexer Beispiele und unter aktiver Einbeziehung der Studierenden das Verständnis gefestigt und durch den Lehrenden unterstützt angewendet werden kann. Auch die Großveranstaltung „Grundlagen der Wirtschaftsinformatik“ (GWI) an der TU Chemnitz soll im Übungsbetrieb durch ein Flipped-Classroom-Konzept verbessert werden. Hierfür werden bestehende Aufgaben mithilfe einer Fachlandkarte und der Bewertung der jeweiligen Lehrziele zu einem Online-Materialien-Pool aufgebaut. Die Präsenzphase soll zur stärkeren Einbeziehung der Studierenden in Form eines aktiven Plenums abgehalten werden.

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16

Floto, Rodrigo Andres. "Fc receptor-triggered intracellular signalling in monocytes." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627016.

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17

Kanmert, Daniel. "Structure and Interactions of Human IgG-Fc." Doctoral thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-65536.

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This thesis involves structure and interaction studies of the Fc fragment of human IgG. For this purpose, hIgG-Fc of different subclasses were cloned and expressed in the eukaryotic host Pichia pastoris, where relevant protein modification at the post-translational level can be obtained. Sometimes, changes in pH, temperature and salt concentration or addition of moderate amounts of denaturants to a protein solution are associated with the protein forming non-natively folded states, such as the molten globule or the A state. IgG and some parts thereof are capable of forming another, so called alternatively folded state, usually induced by acidification in the presence of anions. This state is in many aspects related to the molten globule and the A state but with distinguishing properties related mainly to chemical stability and formation of oligomeric structures. The first part of this thesis describes two different alternatively folded states of hIgG-Fc of subclass 4. One of them was induced by decreasing the pH of the protein solution. Observed structural changes were highly dependent on the concentration of sodium chloride. The alternatively folded protein showed drastic changes in its secondary structure compared to the native protein and significant tertiary structure was lost. Moreover, it displayed an apparently increased chemical stability and had surface exposed hydrophobic patches resulting in the formation of higher order assemblies. In addition, it was shown for the first time that thermal induction of an alternatively folded state is also possible, with similar, but not identical, properties as the acid-induced state. Heat incubation for 20 hours at neutral pH and at a physiological salt concentration further resulted in the formation of protein aggregates. The dye Congo red had affinity for these aggregates, and when viewed under polarized light, it showed green birefringence. They also displayed binding of Thioflavin T and had a typical fibril appearance in the transmission electron microscope. Hence, the formed aggregates share key properties with structures constituting amyloid. The second part of this thesis is focused on interactions of the Fc-fragment with respect to both Fcγ-receptors on monocytes and the IgG autoantibody rheumatoid factor. Immune complexes and their binding to Fcγ-receptors are of pathogenic interest to rheumatoid arthritis. A surface mimic presenting full IgG molecules was designed as an in vitro immune complex model. Utilizing self-assembled monolayers composed of alkanethiolates with different chemical functionalities, the lateral IgG density could be tuned, enabling control of monocyte interaction with the surface. Importantly, the IgG molecules were homogeneously oriented to expose the Fc-fragment. The protein repellent properties of these surfaces ensured that only differences in IgG concentration determined variations in cellular adhesion. In a separate study the specificities of IgG rheumatoid factor with respect to the different subclasses of hIgG-Fc were investigated, using sera from patients with early rheumatoid arthritis. Strikingly high IgG-RF reactivity against hIgG2-Fc was observed, together with raised levels against hIgG1-Fc and hIgG4-Fc. No reactivity against hIgG3-Fc was found.

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18

Stirling, Catriona M. A. "Characterisation of the porcine neonatal Fc receptor." Thesis, University of Sussex, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288146.

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19

Simister, Neil E. "Studies of Fc receptors mediating IgG transport." Thesis, University of Oxford, 1985. http://ora.ox.ac.uk/objects/uuid:14aa3ac3-a440-466f-8871-9f7fdd935cb7.

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20

Antoncich, Ivan. "Resan med FC Nörd : Gemenskap i utanförskap." Thesis, Linköpings universitet, Institutionen för kultur och kommunikation, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-128123.

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Jag kommer i denna uppsats använda min egen upplevelse och mitt eget perspektiv för att kunna återberätta det som kan vara avgörande för att ett fotbollslag ska klara alla hinder framför sig. Vad det kan innebära för otränade individer att sättas i en grupp och försöka fungera som en grupp. Vad ledarskapets roll kan betyda för en grupp eller vad det kan orsaka för problem om den som blir ledare inte vet hur en ledare ska vara eller vad dess roll innebär inom fotboll.vad det innebär att vara i en grupp och vad som krävs att en grupp ska fungera som ett lag.
I will in this paper to use my own experience and my own perspective to retell that which can be crucial to a football team must clear all obstacles in front of him . What that might mean for untrained individuals to be in a group and try to act as a group . What leadership role mean for a group or whatever it may cause problems if that becomes the leader does not know how a leader should be or what its role is in fotboll.vad it means to be in a group and what it takes to a group to work as a team.

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21

Antoncich, Ivan. "Resan med FC Nörd : Gemenskap i utanförskap." Thesis, Linköpings universitet, Institutionen för kultur och kommunikation, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-127632.

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I denna uppsats återberättar jag min upplevelse och mitt perspektiv på vad som kan vara avgörande för att ett fotbollslag ska klara av hinder framför sig. Uppsaten fokuserar på hur skilda individer kan skapa en tillhörighet och gemenskap när de försätts i ett sammanhang där de delar ett utanförskap i samhället. Denna gemenskap i utanförskap kopplas till teorier kring etniska grupper och gruppstrukturer.
In this essay i will retell my experience and my view on what can be crucial for a soccer team to clear all obstacles in front of a team. The paper focus on how different individuals kan create a unity and kinship when they share a context when they are viewed as outsiders in the society. The unity in the exclusion connects to theories about ethnic groups and group structures.

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22

Doonan, James Joseph. "Fc gamma receptor mediated modulation of osteoclastogenesis." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5579/.

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Osteoporosis is a condition that results from substantially weakened bone, increasing an individual’s risk of fracture. Post-menopausal osteoporosis is the most common form of the condition, affecting 30% of post-menopausal women over the age of 50. Following the menopause, female oestrogen levels decline and this perturbs bone homeostasis by promoting an environment that is biased towards bone erosion. Osteoclasts are the cells responsible for eroding bone and are normally inhibited by oestrogen. However, the decline in oestrogen production results in increased osteoclast differentiation and activity. This rapidly decreases the bone mineral density and results in fracture-prone bone. Osteoclasts are derived from mononuclear myeloid progenitors found in the blood and bone marrow, which fuse to form large multinucleated cells that reside in the bone cavity. These progenitor cells are also responsible for replenishing monocytes, macrophages and dendritic cells. One class of receptors present on the surface of these cells, which are capable of dictating a cells function, are Fcγ receptors and modulation of Fcγ receptors has been shown to inhibit the differentiation of human monocytes to osteoclasts. This thesis investigates Fcγ receptor modulation on murine osteoclastogenesis and in order to stimulate Fcγ receptors, both IgG and IgG complexes were used. IgG complexes were generated using Staphylococcus aureus Protein A (SpA) in combination with IgG to form SpA-IgG complexes (SIC). We show that IgG and SIC are capable of engaging with Fcγ receptors resulting in the inhibition of osteoclast differentiation. Furthermore, both IgG and SIC inhibit the transcription of mRNA essential for the fusion of progenitors and enzymes for the erosion of bone matrix. Therefore, IgG and SIC are capable of inhibiting murine osteoclastogenesis. The murine model of osteoporosis was used to further investigate the ability of SIC to inhibit murine osteoclast differentiation. Previous studies have shown that when SpA is administered in vivo it is capable of binding circulating IgG to form SIC. We used this property to test the ability of SpA to bind to the surface of monocytes. SpA was found to bind with highest affinity to blood Ly6Chigh monocytes, which are known to differentiate in vitro to OCs. IgG and SIC were also able to inhibit the in vitro osteoclastogenesis of Ly6Chigh monocytes. It was hypothesised that SpA would co-opt IgG and inhibit the in vivo differentiation of progenitors to osteoclasts in the ovariectomy model of osteoporosis. To generate this animal model the ovaries were removed from the mice in order to simulate the menopause and induce bone loss. To assess the percentage of bone present after ovariectomy, we used micro-computer tomography and discovered that SpA was unable to prevent bone loss associated with ovariectomy. Therefore, SpA can bind to the surface of osteoclast progenitors but is unable to inhibit bone loss in the model of osteoporosis. In addition to studying the role of Fcγ receptor modulation of osteoclastogenesis, the role of Bcl-3 (a negative regulator of NF-κB) in osteoclast differentiation and bone remodelling was also investigated. NF-κB is an essential signalling molecule and transcription factor involved in osteoclast differentiation. Previous research has shown that in the absence of Bcl-3 (Bcl-3-/-) aberrant cytokine responses to LPS and TNF- occur. Therefore, RANKL stimulation of WT and Bcl-3-/- osteoclast precursors was done to determine whether Bcl 3 /- animals responded aberrantly to RANKL. WT and Bcl-3-/- animals were able to generate in vitro osteoclasts, which were phenotypically and transcriptionally similar. However, comparison of in vivo osteoclast progenitors revealed that Bcl-3-/- animals had reduced CD115+ osteoclast progenitors compared to WT animals. Examination of the trabecular bone present in the proximal tibia revealed that Bcl-3-/- animals had a higher percentage of bone present that WT controls. Therefore, Bcl-3 does not effect in vitro osteoclast differentiation but further work needs to be done to understand the role of Bcl 3 in bone remodelling. This thesis aimed to investigate whether SpA-IgG complexes or Bcl-3 could represent a novel avenue of therapeutic intervention in osteoporotic disease. In summation, SpA is able to form IgG complexes that can inhibit the differentiation of OCs in vitro; however, treatment of osteoporotic animals with SpA was unable to halt bone loss. This suggests that SpA-IgG complexes are able to modulate Fcγ receptors in vitro and skew progenitors from differentiation into osteoclasts but cannot overcome the prevailing pro-osteoclastogenic environment that results from ovariectomy. The presence of osteoclast progenitors was also shown to be partially dependent on Bcl-3 and as such Bcl-3 may be a novel target for therapeutic agents to target osteoclast progenitors in diseases like osteoporosis. However, the role of Bcl-3 in bone remodelling requires further investigation.

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23

Buřival, Tomáš. "Opravy DPS s BGA a FC pouzdry." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2009. http://www.nusl.cz/ntk/nusl-217906.

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Graduation thesis is specialized on dilemma of the integrated circuits with ball grid array. Chapter two describes several types of packages and confrontation of their characteristics. Chapter three considers possibilities of corrections these boards bedded with packages, mounting and demounting of these packages, method of camera control and also inspection of the soldering process. Chapter four attend to practical measuring of thermal profiles and their optimalization.

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24

Östman, Zacharias. "Hammers, Lions and Yids: Identity and Ethnicity on British Football Grounds : A Critical Discourse Analysis of the Terrace Chants of West Ham United FC, Millwall FC and Tottenham Hotspur FC." Thesis, Södertörns högskola, Institutionen för kultur och kommunikation, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-5999.

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This essay will show how manifestations of local identity, ethnicity and community in the terrace chants of the three football clubs West Ham United Football Club, Millwall Football Club and Tottenham Hotspurs Football Club are created. By featuring a collection of chants from each club, a connection to the clubs’ geographical areas, the home grounds and ethnic features will be described. By featuring a critical discourse analysis of the language used in the various clubs’ chants at their respective home ground, this essay will display aspects of above mentioned aspects and how these are upheld in language and interaction between people. Each club’s supporters acknowledge allegiance to various communities. West Ham United is traditionally a club of working class Londoners who often relate to themselves as ‘the cockney boys’, while Millwall (although being set in working class London) identifies more with the geographical area (South London) where they are situated, than with their heritage. Tottenham is one of the clubs in Britain most strongly influenced by religion, as many of the supporters are Jews.

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25

Akeel, Mohammed Abdulraheem Mohammed. "The generation and characterisation of DigLON-Fc (CO-Fc) recombinant protein and its interactions with the putative neuronal receptors." Thesis, University of Liverpool, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540042.

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26

Van, Zyl Dwain George. "Production of recombinant human CD21 and CD23 : towards a better understanding of their interaction." Thesis, Nelson Mandela Metropolitan University, 2013. http://hdl.handle.net/10948/d10211135.

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The prevalence of allergic diseases has dramatically increased over the last three decades. Presently, it is estimated that 20-30 per cent of the developed world suffers from allergic diseases. The majority of allergic diseases are rooted in the activities of IgE; an immunoglobulin which exerts its effector functions by interacting with a network of proteins. This network includes its low affinity receptor CD23. Cross linking of membrane IgE and CD21 by soluble CD23 results in an increase in IgE synthesis. This marks the interaction between CD23 and CD21 as an attractive therapeutic target. However, details regarding this interaction are inadequate for rational drug design. To obtain a deeper understanding of the CD23-CD21 interaction recombinant human CD21 (SCR1-2 and SCR5-8) and CD23 (16 kD and 25 kDa) were produced. The cloning, expression and purification of recombinant proteins comprised a significant portion of this study. Recombinant CD23 was expressed as inclusion bodies, refolded by rapid dilution and purified by size exclusion chromatography. Conversely, recombinant CD21 was expressed as soluble MBP-fusions and purified with an amylose affinity resin. The interaction between recombinant CD23 and CD21 was analysed by flow cytometry and ELISA experiments. Flow cytometry showed that 16 kDa and 25 kDa CD23 interacted with SCR5-8 to the same extent. Semi-quantitative ELISA experiments showed that both SCR1-2 and SCR5-8 were able to interact with 16 kDa and 25 kDa CD23. This suggests that the binding sites of SCR1-2 and SCR5-8 occur on 16 kDa CD23. Furthermore, since proteins were expressed in E. coli it suggests that the CD23-CD21 interaction does not require glycosylation. Furthermore, considering what is known about the SCR1-2-CD23 interaction from previous NMR studies; i.e. that the C-terminal tail (residues residues 289-298) of CD23 is responsible for binding SCR1-2, indicates that SCR5-8 binds somewhere within the lectin domain of CD23. This indicates that the CD23-CD21 interaction involves C-terminal tail-SCR1-2 and lectin domain-SCR5-8 interactions.

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27

Brown, Kirsty Stevenson. "Fc#gamma#RIIb : signalling aspects and implications for autoimmune disease." Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249965.

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28

Pinel, Patrick. "Expression du récepteur Fc par les polynucléaires au cours de la migration à travers la peau humaine." Nantes, 1986. http://www.theses.fr/1986NANT3565.

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29

Joshi, Trupti Prabhakar. "Molecular analysis of the role of Fc[gamma]b, SHIP and PI 3-kinase in macrophage Fc[gamma] receptor function." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1180983336.

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30

Benadda, Samira. "Le rôle du système endosomal dans la fonction des récepteurs activateurs aux fragments Fc des immnunoglobulines : exemples du RFcyI." Thesis, Université de Paris (2019-....), 2019. http://www.theses.fr/2019UNIP7075.

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Les Récepteurs aux fragments Fcs des immunoglobulines (RFcs) sont des récepteurs majeurs du système immunitaire, présents à la surface des cellules immunes et faisant l’interface entre l’immunité innée et l’immunité adaptative. Ils reconnaissent la partie Fc des immunoglobulines des complexes immuns (IC) constitués d’un antigène et d’une immunoglobuline spécifique déclenchant des voies de signalisation qui déterminent la production de médiateurs anti- ou pro-inflammatoires ainsi que d’autres réactions permettant l’élimination de l’infection. Après la liaison de la partie Fc des ICs, le récepteur et les ICs sont internalisés. Il est connu que cette internalisation permet la présentation de l’antigène contenu dans les ICs et l’élimination de pathogènes internalisés, mais le rôle de l’internalisation dans la transduction du signal via les RFcs n’avait pas été bien étudié auparavant. Nous avons étudié le rôle du système endosomal dans la fonction des RFcs et montré que le RFcγI, récepteur de haute affinité aux IgG, continue à signaler via des plates-formes de signalisation endosomale, ce qui serait un mécanisme essentiel pour l'activation complète des fonctions clés des RFcs. Les endosomes caractérisés par l’aminopeptidase insulinodépendante IRAP constituerait une plateforme de signalisation pour le RFcγI. De manière similaire, nous avons mis en évidence que la sous unité CD3ζ du TCR, récepteur au lymphocyte T, forme un pool intracellulaire dans les endosomes contenant IRAP et la syntaxine STX6. Nos résultats montrent que le TCR continue de signaler après l'endocytose et que cette signalisation intracellulaire est particulièrement importante pour l’activation de la cellule T par des complexes peptide-CMH de faible affinité
Immunoglobulin Fc receptors (FcR) are cell surface immune receptors at the interface between innate and adaptive immunity. They recognize the Fc part of the immunoglobulin of the immune complexes consisting of an antigen and a specific immunoglobulin. They trigger signaling pathways that determine the production of anti- or pro-inflammatory mediators and other reactions allowing the elimination of infection. After the binding of ICs, the receptor and the ICs are internalized. It is known that this internalization allows the presentation of the antigen contained in the ICs and the elimination of internalized pathogens, but the role of internalization in signal transduction via RFCs has not been well studied before.We investigated the role of the endosomal system in FcR function and we showed that the FcγR1, a high affinity IgG receptor, continues to signal via endosomal signaling platfrorms, which would be essential for the complete activation of the receptor functions. The endosomes characterized by insulin-dependent aminopeptidase IRAP constituted a signaling platform for RFcγI. Similarly, we have demonstrated that the CD3ζ subunit of the TCR, the lymphocyte T receptor, form an intracellular pool in the endosomes containing IRAP and the syntaxine STX6. Our results demonstrate that the TCR continues to signal after endocytosis and that this intracellular signaling is particularly important for T cell activation by low affinity peptide-MHC complexes

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31

Engelmark, Andreas. "FC Barcelonas olika uppställningar – Ett anfallsspel med flexibilitet." Thesis, Gymnastik- och idrottshögskolan, GIH, Tränarlänken, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-1361.

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32

Romero, Alirio Jose Melendez. "Intracellular signalling pathways activated by Fc#gamma#RI." Thesis, University of Glasgow, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266462.

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33

Socolovsky, Merav. "Function of Fc IgG receptors in heterologous cells." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318347.

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Stephens, Lauren Ellis. "Interaction of immunoglobulins with primate Fc[gamma]RIIIa." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708276.

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35

Mekhaiel, David. "Fc-fusion proteins as adjuvants and therapeutic reagents." Thesis, University of Nottingham, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.662197.

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Fc-fusions proteins are a growing class of bio-therapeutics, widely used in the clinic as well as off label applications. In this work, the ability of the Fc region of IgG to act as an immunological adjuvant when fused to antigen was investigated. Fc-fusions were constructed, produced and purified, wherein the malarial antigen, MSP119, was fused to the Fc region of either mouse IgG2a or human IgG1. These monomeric Fc-fusion proteins were found to bind to Fc gamma receptors (FcyRs) in a similar fashion to the antibodies they were derived from. Immunisation of mice with these fusions resulted in the production of MSP119-specific antibodies, predominantly murine IgGl, with lower levels of IgG2a and IgG2b. However, these MSP119-specific antibodies had no influence on the course of a subsequent malarial challenge. In order to improve the immunogenicity of these monomeric Fc-fusion proteins, critical residues from IgM (a polymeric class of antibody) were introduced in an attempt to polymerise these fusions. The modifications described here, resulted in the formation of dimeric and barrel shaped hexameric IgGl based fusions, whilst failing to induce polymerisation of the mlgG2a based fusion proteins. In immunisation studies, these hexameric Fc-fusions were found to be less immunogenic than their monomeric counterparts, and again, failed to protect from challenge. Analysis of hexameric Fc-fusion binding to FcyRs revealed that the inclusion of the fusion partner, MSP119, significantly reduced the ability of the fusions to bind FcyRs. The ability of the hexameric Fc scaffold alone to act as a replacement for intravenous immunoglobulins (IVIG) in the treatment of immune thrombocytopenia (ITP) was also investigated. At the dose used in this work, under 2% of the commonly used dose of IVIG, the hexameric IgGl scaffold offered no amelioration of experimental ITP in mice. This work described here forms the foundation for the future use of stable well defined barrel shaped hexameric Fc-fusions, both as a platform for use in vaccination, and as a therapeutic reagent.

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36

Bell, Robert William II. "Three dimensional FC Artin groups are CAT(0)." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1054781795.

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37

Maresco, Diane L. "Biological studies of the human IgG Fc receptors /." The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487948440825252.

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38

Lowry, Malcolm B. "Functional analysis of Fc[beta] receptor-mediated phagocytosis /." The Ohio State University, 1998. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487950153603095.

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39

Hossain, Md Kamal. "Targeting Fc Receptors for More Effective Cancer Vaccines." University of Toledo Health Science Campus / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=mco1544800037742347.

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40

Puwanich, Patana. "Rapid imaging of free radicals using FC-PEDRI." Thesis, University of Aberdeen, 1999. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU602006.

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In the work described in this thesis, new techniques to reduce the electron paramagnetic resonance (EPR) irradiation power required in field cycled proton electron double resonance (FC-PEDRI) and to improve the temporal resolution of FC-PEDRI have been investigated. These are the aims of this work. Details of free radicals and basic principles of EPR and EPR imaging are given and the fundamentals of NMR are also described. The principles of NMR imaging (MRI) are summarised and the essential hardware of MRI for the experiments are also described. Details of PEDRI and FC-PEDRI are also described in this thesis. It is widely realised in MRI that a surface coil, or local RF coil, generates very strong magnetic fields in the coil proximity and that the field decreases rapidly with the distance away from the coil. This should be a useful advantage to limit the EPR irradiation within the desired area of the sample. Hence, the use of a surface coil as an EPR irradiation resonator has been investigated. Not only is the EPR irradiation restricted to the area of interest close to the surface coil but a stronger RF field and high SNR are also generated in this region too. The double resonance coil assembly developed here consisted of a split-solenoid coil (for NMR) and a loop-gap resonator surface coil (for EPR). The results confirmed that the enhancement of NMR signal was higher compared to the whole-body birdcage EPR coil used previously and that the enhancement area was restricted within the proximity of the surface coil. Using the technique of rapid imaging in NMR with FC-PEDRI, fast imaging of free radicals has been investigated. A number of fast pulse sequences are presented in this thesis. A snapshot centric-reordered phase-encoding pulse sequence using the technique of population preparation has been studied and employed. With an essential ideal of EPR irradiation applied only once followed by a snapshot NMR imaging pulse sequence, the EPR power is greatly reduced and the temporal resolution is greatly improved, too. However, the experimental results showed that the image quality needed much improvement and this technique is still limited to be used with samples where the longitudinal relaxation time (Ti) is longer than 250 ms. Next, the rapid imaging of free radicals in very short Ti samples equivalent to biological tissue (typically Ti of -150 ms) was investigated. The basis of image artefacts was studied. From the experimental results, it was found that the snapshot NMR pulse sequence must be commenced very soon after the end of field cycling to avoid the signal enhancement decay. To address the problem of image artefacts, the NMR FID data have been analysed. As a result, phase shift correction and amplitude adjustment schemes have been adopted and applied to the FID data. Details of the data correction schemes are given. Experiments employing rapid imaging of free radicals in vivo using FC-PEDRI are presented. The results show that the rapid imaging in vivo using this technique are possible. However, the resulting images are still noisy. More study is required for further refinement of this technique. Experiments using EPR surface coils with rapid FC-PEDRI were also investigated. The preliminary results obtained from biological-equivalent samples show the possibility of the use of this method in in vivo experiments.

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Bell, Robert William. "Three dimensional FC Artin groups are CAT(0) /." Connect to this title online, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1054781795.

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Thesis (Ph. D.)--Ohio State University, 2003.
Title from first page of PDF file. Document formatted into pages; contains viii, 103 p.; also includes graphics Includes bibliographical references (p. 102-103). Available online via OhioLINK's ETD Center

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Fernandes, Luciana. "Implementação do interpretador Pascal-FC usando IPC-Unix." Florianópolis, SC, 2004. http://repositorio.ufsc.br/xmlui/handle/123456789/87417.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Ciência da Computação.
Made available in DSpace on 2012-10-21T19:45:25Z (GMT). No. of bitstreams: 0
Este trabalho apresenta a implementação de uma versão do interpretador da linguagem PASCAL-FC. Em sua versão original, o código concorrente é executado seqüencialmente, apenas simulando a execução de processos concorrentes. Seu ambiente de execução é chamado de pseudoparalelo, o que é suficiente para uma ferramenta didática de programação concorrente. Na versão aqui apresentada, o código compilado é executado em um fluxo principal que se divide em n fluxos de execução independente, que são fluxos de processos independentes. A utilização de processos baseados no modelo UNIX-IPC, como processos, semáforos, segmentos de memória compartilhada e filas de mensagens,

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Lejeune, Julien. "Génétique et génomique des récepteurs de faible affinité pour le IgG - Implications pour le développement et l'analyse de la variabilité des effets des anticorps thérapeutiques." Thesis, Tours, 2010. http://www.theses.fr/2010TOUR3140/document.

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Les récepteurs Fc jouent un rôle important en permettant aux cellules de l’immunité d’interagir avec lesanticorps, notamment thérapeutiques. Dans cette thèse, nous montrons que des mécanismes de recombinaisonhomologue, de knock-in par insertion rétrovirale et de duplication segmentale ont permis l’acquisition chez lesPrimates (FCGR2A) puis chez les Hominidés (FCGR2C et FCGR3B) de gènes codant des récepteurs Fc ayantde nouvelles propriétés, tout en rendant instable ce cluster (variation de nombre de copies), et très complexeson analyse chez l’Homme. Grâce à une approche originale de pyroséquencage, nous sommes parvenus àétudier simultanément le polymorphisme allélique ORF/STOP du FCGR2C, ainsi que son nombre de copies.Nous avons ainsi révélé de nouveaux déséquilibres de liaison, s’ajoutant au déséquilibre FCGR3A-FCGR2Adont nous avons montré l’importance d’une prise en compte adaptée dans les études d’association avec laréponse aux anticorps thérapeutiques. Ces résultats devraient contribuer à améliorer le développement préclinique(pertinence des modèles animaux) et clinique (variabilité des effets) des anticorps thérapeutiques
Fc receptors play an important allowing connexion between immune cells and antibody notably therapeutic. Inthis thesis, we have shown that homologous recombination events, knock-in by retroviral insertion andsegmental duplication led to the acquisition in primates (FCGR2A) then in Hominids (FCGR2C and FCGR3B)of genes coding for Fc receptors with new properties, led to genomic instability of the cluster (copy numbervariation) and to complex analysis in human. Through a original pyrosequencing approach, we have studiedsimultaneously ORF/STOP polymorphism and copy number variation of FCGR2C. We have also revealed newlinkage disequilibrium, additionnaly to FCGR3A-FCGR2A disequilibrium which we have shown theimportance of a suitable methdology in association studies with responses to therapeutic antibodies. Theseresults contribute to improve pre-clinical (of animal models) and clinical (variability effects) development oftherapeutic antibodies

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44

Heusohn, Frank. "Molekulare Analyse der regulierten Genexpression in NK/T-Zellen am Beispiel des humanen Fc[gamma]RIIIA-Rezeptors [Fc-gamma-RIIIA-Rezeptors]." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=962838004.

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45

Lewis, Clinton Dean. "Development of a maintenance advisor expert system for the MK 92 MOD 2 Fire Control System : FC-1 Designation - Time, FC-1 Track - Bearing, Elevation and Range, and FC-2 Track - Bearing, Elevation and Range." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from the National Technical Information Service, 1993. http://handle.dtic.mil/100.2/ADA275160.

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46

Allred, Laura K. "Polymorphic variants of Human Fc-GAMMA-RIIIa, gamma-chain, CTLA-4 and Fc-GAMMA-RIIb1 : possible implications for systemic Lupus Erythematosus Pathogenesis /." The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486394475979377.

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47

Li, Ping. "The binding characteristics of CD16a binding and its inhibition." Diss., Georgia Institute of Technology, 1999. http://hdl.handle.net/1853/15865.

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48

Hardie, Diana Ruth. "Characterization of an Fc-receptor for human IgG in the tegument of human cytomegalovirus." Master's thesis, University of Cape Town, 1991. http://hdl.handle.net/11427/26353.

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49

Cohen-Solal, Joël. "Étude des structures et fonctions des récepteurs de faible affinité pour la portion Fc des immunoglobulines G." Paris, Muséum national d'histoire naturelle, 2004. http://www.theses.fr/2004MNHN0003.

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Les RFcgIIIb cristallisent sous forme de dimères. In vivo ils sont physiquement distants donc non dimériques. L'étude de mutants confirme le rôle essentiel du domaine 2 dans la fixation des IgG et révèle le rôle inattendu du domaine 1 dans la modulation de leur affinité pour les IgG. Par ailleurs, l'étude de sa glycosylation révèle une forte présence de Mannose, absente du mRFcgII, qui pourrait rendre compte de l'interaction RFcgIIIb-CD11b. Le hRFcgIIb, d'expression hématopoi͏̈étique, est un récepteur inhibiteur. Les mélanomes métastatiques humains l'expriment ectopiquement. Ce hRFcgIIb tumoral induit l'inhibition de la croissance des mélanomes in vitro ou greffés aux souris immunodéficientes. Pour étudier la relation "hôte-tumeur" dans un hôte immunocompétent, nous avons inoculé aux souris le mélanome B16F0 exprimant le mRFcgIIb1. Ce modèle révèle le rôle de "leurre" du mRFcgIIb1 tumoral qui permet aux mélanomes d'échapper à la réponse antitumorale humorale
FcgRIIIb are dimeric in the crystal lattice but not in vivo where they are physically distant as shown by chemical crosslinking. Mutants study confirmed the essential role of domain 2 in IgG binding and enlightened the role of domain1 in the modulation of IgG binding affinity. Glycosylations study revealed high mannose sugar, which are absent from mFcgRII and could be implicated in the specificity of FcgRIIIb - CD11b interaction. HFcgRIIb expressed specifically on hematopoietic cells is an inhibitory receptor. Human metastatic melanoma express it ectopicaly. These tumoral hFcgRIIb inhibit melanoma growth in vitro as well as in vivo for tumor grafted in immunodeficient mice. To study the "Tumor-host" immunological relationship, the murin B16 melanoma expressing mFcgRIIb have been inoculated into immunocompetent mice. This model shown the decoy role of tumoral mFcgRIIb expression which allow the melanoma to escape antitumor humoral response

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50

Pasquier, Benoit. "Dualité fonctionnelle du récepteur aux fragments constants des Immunoglobulines A : RFcαI ou CD89." Paris 5, 2004. http://www.theses.fr/2004PA05N032.

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Les IgA sériques sont décrites comme ayant des propriétés anti-inflammatoires, alors que les complexes immuns à IgA induisent des réponses inflammatoires. Nous avons identifié le récepteur aux IgA, le RFcα comme le médiateur de ces deux fonctions, activatrice et inhibitrice. Les IgA en l'absence d'antigène, ou le fragment Fab d'un Acm anti-RFcαI inhibe la réponse de récepteurs hétérologues, alors que l'agrégation du RFαI par des complexes à IgA médie l'activation cellulaire. Nous avons identifié le motif ITAM de la chaîne γ comme étant impliqué dans ces deux fonctions. L'absence d'agrégation du RFcαI induit une phosphorylation partielle de la chaine γ, permet le recrutement de la phosphatase SHP-1 au RFcαI et induit la déphosphorylation des protéines Syk, LAT et ERK
Serum IgA is considered a housekeeper of the immune system with anti-inflammatory functions whereas IgA-immune complexes mediate inflammation. Here, we identify FcαRI or CD89 as the molecular device that determines the nature of IgA responses In the absence of sustained aggregation, receptor targeting by IgA or anti-FcαRI Fab inhibits activatory responses of heterologous receptors. The inhibitory mechanism involves recruitment of the tyrosine phosphatase SHP-1 to FcαRI, thereby affecting Syk, LAT and ERK phosphorylation. Conversely, sustained aggregation of FcαRI by multimeric ligands stimulates cell activation. Both signals require the FcαRγ-ITAM motif. Anti-FcαRI fab treatment suppresses manifestations of allergic asthma in FcαRI transgenic mice

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