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1

Station, Iowa Agriculture and Home Economics Experiment. Dietary modifications designed to affect lipid metabolism. Ames, Iowa: The Station, 1992.

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2

Cone, Joseph. A common fate: Endangered salmon and the people of the Pacific Northwest. Corvallis: Oregon State University Press, 1996.

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3

Cone, Joseph. A common fate: Endangered salmon and the people of the Pacific Northwest. New York: H. Holt, 1995.

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4

(Josie), Santomauro J., ed. Friendly facts: A fun, interactive resource to help children explore the complexities of friends and friendship. Shawnee Mission, Kan: Autism Asperger Pub. Co., 2010.

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5

Barnard, Neal. Foods that cause you to lose weight: The negative calorie effect. McKinney, TX: MagniGroup, 1992.

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6

Karen, Bellenir, Dresser Peter D, and National Institutes of Health (U.S.), eds. Cardiovascular diseases and disorders sourcebook: Basic information about cardiovascular diseases and disorders featuring facts about the cardiovascular system, demographic and statistical data, descriptions of pharmacologic and surgical interventions, lifestyle modifications, and a special section focusing on heart disorders in children. Detroit, MI: Omnigraphics, 1995.

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7

Hughes, Stella E., and Gabrielle Macaron. Fast Facts : Multiple Sclerosis: A New Era of Disease Modification and Treatment. Health Press Limited, 2021.

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8

Macaron, G., and S. E. Hughes. Fast Facts : Multiple Sclerosis: A New Era of Disease Modification and Treatment. Karger AG, S., 2021.

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9

Toplis, Blake Stephen. Tracking, adaptability and stability modifications for fast recursive least squares algorithms. 1987.

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10

Poplack, Shana. The bare facts of borrowing. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190256388.003.0006.

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This chapter addresses the problem of classifying formally ambiguous bare forms. It illustrates with analysis of three typologically distinct language pairs involving isolating recipients (Wolof, Fongbe, and Igbo) that feature virtually no overt morphology on the noun, obviating the morphological criterion for loanword integration. Here the appeal is to the syntax of nouns and noun phrases, focusing on their variable distribution across different types of modification structure. This expands and systematizes the comparisons of chapters 4 and 5 by considering in greater detail not just the rates of occurrence of a diagnostic but also its variable structure. Regardless of language pair, the overwhelming majority of lone donor-language nouns display quantitative parallels to their relevant recipient-language counterparts in ways far too specific to be random. At the same time, they pattern differently from nouns in unmixed donor-language contexts. This reveals that the donor-language nouns have been borrowed and integrated into different recipients.
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11

Hooper, Amanda J., and John R. Burnett. Abetalipoproteinemia and Hypobetalipoproteinemia. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199972135.003.0037.

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Abetalipoproteinemia and hypobetalipoproteinemia are characterized by marked hypocholesterolemia and are classified depending on the lipid biochemical phenotype, gene involved, and mode of inheritance of the condition together with the severity of the mutation or mutations present. These disorders may or may not be associated with clinical manifestations such as fat malabsorption, growth failure, fat-soluble vitamin deficiency, fatty liver disease, and neuro-ophthalmological dysfunction. Early diagnosis and treatment with dietary modification and replacement of fat-soluble vitamins can prevent the clinical complications.
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12

Ozéias de Jesus dos Santos. Prática de Processo Civil Art. 350: Fato Impeditivo, Modificativo Ou Extintivo Do Direito. Independently Published, 2017.

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13

Zeitlin, Vladimir. Getting Rid of Fast Waves: Slow Dynamics. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198804338.003.0005.

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After analysis of general properties of horizontal motion in primitive equations and introduction of principal parameters, the key notion of geostrophic equilibrium is introduced. Quasi-geostrophic reductions of one- and two-layer rotating shallow-water models are obtained by a direct filtering of fast inertia–gravity waves through a choice of the time scale of motions of interest, and by asymptotic expansions in Rossby number. Properties of quasi-geostrophic models are established. It is shown that in the beta-plane approximations the models describe Rossby waves. The first idea of the classical baroclinic instability is given, and its relation to Rossby waves is explained. Modifications of quasi-geostrophic dynamics in the presence of coastal, topographic, and equatorial wave-guides are analysed. Emission of mountain Rossby waves by a flow over topography is demonstrated. The phenomena of Kelvin wave breaking, and of soliton formation by long equatorial and topographic Rossby waves due to nonlinear effects are explained.
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14

Mary Ellen, O’Connell. Part 3 The Post 9/11-Era (2001–), 63 The Crisis in Ukraine—2014. Oxford University Press, 2018. http://dx.doi.org/10.1093/law/9780198784357.003.0063.

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On 28 February 2014, Russian forces moved out of their base on the Black Sea into Crimea, triggering a crisis with Ukraine that quickly spread to Eastern Ukraine. Russia has attempted to justify its actions in Ukraine. On close analysis, no argument is adequate to avoid the charge of aggression, which is any serious violation of United Nations Charter Article 2(4). Article 2(4) is no mere treaty rule. It is jus cogens, a peremptory norm, meaning it is durable, impervious to modification. Facts on the ground in Ukraine may remain unchanged without sufficient international pressure. Regardless, Russia’s presence will remain unlawful.
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15

Jappelli, Tullio, and Luigi Pistaferri. Conclusions. Oxford University Press, 2017. http://dx.doi.org/10.1093/acprof:oso/9780199383146.003.0015.

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The final chapter summarizes the material covered by the book, offering our perspectives on areas of consent, disagreement, and future research. The book analyzes how consumers respond to changes in their economic environment and react to risks they face during the life cycle. In addressing these issues, the basic life-cycle permanent-income model is augmented with other significant features of consumers’ preferences and environment: precautionary motives for saving, borrowing constraints, life span uncertainty, intergenerational transfers, non-separability between consumption and leisure, habits, and financial sophistication. By and large, one can reconcile some puzzling facts present in the empirical data by means of relatively modest modifications of the basic version of the model, such as provision for home production and non-separable preferences between consumption and leisure. However, in order to explain other “anomalies” and “puzzles” observed in individuals’ actual saving and financial behaviors, more important modifications to the standard framework are required.
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16

Cone, Joseph. Common Fate: Endangered Salmon and the People of the Pacific Northwest. Holt & Company, Henry, 2014.

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17

Cone, Joseph. A Common Fate: Endangered Salmon and the People of the Pacific Northwest. Henry Holt & Co, 1994.

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18

Harper, Ryan P. The Gaithers and Southern Gospel. University Press of Mississippi, 2017. http://dx.doi.org/10.14325/mississippi/9781496810908.001.0001.

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This ethnography examines songwriters Bill and Gloria Gaithers’ Homecoming video and concert series. The Homecomings re-present the “southern gospel” subgenre of gospel music—a musical style popular among white evangelical Christians in the American South and Midwest. The book explores how the Gaithers negotiate the tension between preservation and modification of community norms as they seek simultaneously to maintain and expand their audience, and to initiate and respond to ideological shifts within their fan base’s culture. Using data he collected from his immersion in the Homecoming catalogue, his attendance of numerous concerts and tapings, and his extensive conversations with Homecoming fans and the Gaithers themselves, Harper reveals the Homecomings to be a crucible of American religious, racial, sexual and regional identity formation.
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19

Riccardi, Gabriele, and Maria Masulli. Overweight, obesity, and abdominal adiposity. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199656653.003.0013.

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Obesity is a serious chronic disease of epidemic and global proportions. The incidence of cardiovascular diseases (CVD) is increased in obese people. Since overweight and obesity are associated with decreased lifespan, weight loss might be expected to improve long-term survival and to have beneficial effects on CVD risk. The therapeutic approaches for obesity are lifestyle changes, drugs, and bariatric surgery. Lifestyle modifications include modest weight loss and moderate-intensity physical activity. A low-fat (low saturated fat), low-sugar diet rich in fruit and vegetables, as well as legumes and whole grains, should be advised for its beneficial impact on weight and cardiovascular risk. Bariatric surgery represents an effective treatment in cases of severe obesity. Prevention of overweight and obesity at the population level will probably play a major role in combating the present obesity epidemic. Combining different intervention strategies is probably the best choice for maximizing the effects and minimizing the costs.
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20

Karpyn, Allison. Behavioral Design as an Emerging Theory for Dietary Behavior Change. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190626686.003.0003.

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In the past two decades, public health interventions have moved from education strategies aimed at individuals to broad, multilevel interventions incorporating environmental and policy strategies to promote healthy food behaviors. These intervention programs continue to employ classic behavior change models that consider individuals as deliberate, intentional, and rational actors. Contrary to the ideas posited by rational choice theory, diet-related literature draws little correlation between an individual’s intentions and his/her resultant behavior. This chapter adds to the dual-system model of cognition—reflective or slow thinking, and automatic or fast thinking—and introduces an emerging theory for dietary behavior change called behavioral design. Behavioral design recognizes that human decisions and actions lie on a continuum between spheres and are continually shaped by the interactions between an agent (individual, group) and his/her/their exposure (environment). More specifically, behavioral design considers the importance of the “experience” left as time passes, such as conditioning, resilience, expectation, repeated behaviors, and normality, as the central and iterative influence on future decisions. Behavioral interventions must consider the individual’s “experience” resulting from his or her interaction with the environment, while acknowledging the fast and slow mechanisms by which choices are made. This chapter introduces aspects to consider when using behavioral design to increase healthier food behaviors and physical activity, and briefly discusses ethics questions related to intentional modification of environment for health behavior change.
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21

Barnard, Neal, and Neal D. Barnard. Foods That Cause You to Lose Weight:: The Negative Calorie Effect. Avon, 1999.

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22

Barnard, Neal. Foods That Cause You to Lose Weight. Magni Co, 1998.

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23

Barnard, Neal. Foods That Cause You to Lose Weight: The Negative Calorie Effect. Magni Company, 1998.

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24

Mullin, Gerard E., Marvin Singh, Alyssa Parian, and Andrew T. Weil, eds. Integrative Gastroenterology. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780190933043.001.0001.

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Digestive diseases encompass numerous acute and chronic conditions of the gastrointestinal tract, ranging from common digestive disorders to serious, life-threatening diseases. Over 60 million Americans are afflicted with known digestive diseases with the association of many other adverse health conditions and disability. The annual economic impact on the US economy is more than $141 billion. The Western diet and lifestyle contribute to this high prevalence of digestive disease in America and worldwide. The most common digestive conditions in the United States, Canada, and Europe were uncommon in Asia and Africa until recently with the expansion of fast-food franchises and heightened availability of processed foods worldwide. Digestive diseases have a complex underlying pathogenesis that involves a number of influences, including environmental factors, genetics, inflammation, and the gut microbiome. The risk of developing digestive disease is adjustable by making key dietary and lifestyle modifications. Adopting a personalized approach to digestive illness can achieve improved patient satisfaction and quality of life for patients.
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25

Michelman, Frank I. Constitutional Essentials. Oxford University PressNew York, 2022. http://dx.doi.org/10.1093/oso/9780197655832.001.0001.

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Abstract This work examines closely the constitution-centered proposition on political legitimacy, offered by John Rawls in Political Liberalism in response to the problem posed for government by consent by facts of deep-lying disagreement among citizens. An answer, Rawls thought, could lie in the possibility of a framework law for a society’s politics—a “constitution,” including a bill of rights—that all, despite other disagreements, could find reason to accept. The work offers explication of the thought behind Rawls’s proposal, while also placing it in relation to a duality of functions—–“regulatory” and “justificatory”—for which lawyers in constitutional-democratic societies typically look to their countries’ bodies of constitutional law. Conflicts in practical implications from these functional attributions, the work suggests, can help explain the persistence of debates in constitutional-democratic venues over topics ranging from choices between “legal” and “political”—or between “written” and “unwritten”—constitutions, to thinness versus thickness in formulations of constitutional principles and guarantees, the place of constitutional fidelity among liberal political virtues, activism versus restraint in the conduct of judicial constitutional review, original-meaning versus moral-reading approaches to constitutional interpretation, and extension of constitutional substantive guarantees beyond negative restraints on the government to take in affirmative state obligations for satisfaction of the basic material needs of citizens, and for protection of them against oppression from nongovernmental social powers. The book also looks into whether some later-arriving work from Rawls signifies modification of the procedurally dependent basis for political justification than it finds in the first edition of Political Liberalism.
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26

Maj, Dorota. Modyfikujący wpływ roślinnych dodatków paszowych na użytkowość mięsną i ekspresję wybranych genów u królików w zależności od wieku i płci. Publishing House of the University of Agriculture in Krakow, 2017. http://dx.doi.org/10.15576/978-83-66602-29-8.

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The aim of the study was to determine the effect of feed additives (algae, soybean, and sunflower oil) used in the rabbit feed on: growth indices and slaughter traits, pH, colour, texture, chemical composition, fatty acid profile and oxidative stability (TBARS) of the meat as well as FTO and FABP4 genes expression in the meat’s intramuscular fat (m. longissimus lumborum), depending on the age and sex. The experimental material consisted of Termond White rabbits (n = 160, 80 females and 80 males). Animals were weaned on the 35th day of life, and housed in metal cages arranged in batteries (4 rabbits of the same sex in a cage). From weaning to 12 or 18 weeks of age, the rabbits were fed pellets ad libitum. Animals in the control group (C) received non-supplemented pellets throughout the experiment. In the other groups, the pellet contained 1% algae (A), 3% sunflower oil (OS), and 3% soybean oil(SO).The experimental diets were formulated to have similar protein and energy content. Diets were balanced by lowering the proportion of other feed components. The total share of all components remained at 100%. The results indicate that 3% vegetable oils (soybean or sunflower) supplementation of diets for growing rabbits leads to an increase of body weight and improvement of some of the slaughter traits, while 1% addition of algae to the feed causes deterioration of body weight and slaughter traits. The effect of oil additive depends on the animals’ age. Supplementation of the rabbits’ diet with algae (1%) or sunflower and soybean oils (3%) led to an increase in the dressing percentage of rabbits slaughtered at 18 weeks of age (approx. 3%), but had no effect on the dressing percentage of rabbits slaughtered at 12 weeks of age. Feeding pellets with either 3% vegetable oils or 1% algae additive to the rabbits did not significantly change the chemical composition of the meat. Protein content increased and intramuscular fat content decreased with age, while ash and water content were similar. The feed additives significantly differentiated meat acidity without deteriorating meat quality. Diet modification has not affected negatively meat colour. 24 h after the slaughter, the colour of rabbit meat was similar across the studied feeding groups. Correlation between diet and rabbits’ age was found. Meat texture (hardness, springiness and chewiness) of all rabbit groups slaughtered at 12 weeks of age was similar, and the shear for cewas greater in rabbits fed pellets with algae and soybean oil. At 18 weeks of age, rabbit meat from experimental groups had lower hardness and chewiness, compared to meat of the animals from the control group. Meat shear force was higher in the control group, and from algae-supplemented group. The correlation between diet and age was also found. The use of 3% vegetable oils or 1% algae as feed additives significantly reduced meat oxidative stability. Soybean or sunflower oil (3%) usedas feed additives favourably modified the fatty acid composition of intramuscular fat. Polyunsaturated fatty acids (PUFA) content was increased, including linoleic acid, and PUFA/MUFA ratio was improved. The content of these acids decreased with age. The use of algae (1%) as a feed additive resulted in positive effect on the increase of n-3 fatty acid content (EPA and DHA) in meat intramuscular fat. Algae supplementation improved pro-health properties of meat, with low n-6/n-3 acid ratio (2.5), indicating that diet modification may affect the fatty acid composition of rabbit meat. The influence of diet and age on FTO and FABP4 gene expression in meat intramuscular fat (m. longissimus lumborum) was found. FTO and FABP4 gene expression increased with age and was the highest in the group of rabbits with 1% algae supplementation in the diet. The effect of rabbits’ gender on growth, slaughter traits, meat quality and gene expression in rabbits was not observed. In conclusion, the use of natural feed additives, such as sunflower, soybean oil or algae, can improve the nutritional value of rabbit meat, without changing its chemical or physical properties, and therefore the meat can serve as functional food, with properties beneficial to human health. The results obtained in this study also indicate that the expression of FTO and FABP4 genes in rabbit muscles is regulated by dietary factors and age, which, in addition to cognitive significance, has practical implications for improving technological and dietary quality of rabbit meat.
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27

Hilgurt, S. Ya, and O. A. Chemerys. Reconfigurable signature-based information security tools of computer systems. PH “Akademperiodyka”, 2022. http://dx.doi.org/10.15407/akademperiodyka.458.297.

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The book is devoted to the research and development of methods for combining computational structures for reconfigurable signature-based information protection tools for computer systems and networks in order to increase their efficiency. Network security tools based, among others, on such AI-based approaches as deep neural networking, despite the great progress shown in recent years, still suffer from nonzero recognition error probability. Even a low probability of such an error in a critical infrastructure can be disastrous. Therefore, signature-based recognition methods with their theoretically exact matching feature are still relevant when creating information security systems such as network intrusion detection systems, antivirus, anti-spam, and wormcontainment systems. The real time multi-pattern string matching task has been a major performance bottleneck in such systems. To speed up the recognition process, developers use a reconfigurable hardware platform based on FPGA devices. Such platform provides almost software flexibility and near-ASIC performance. The most important component of a signature-based information security system in terms of efficiency is the recognition module, in which the multipattern matching task is directly solved. It must not only check each byte of input data at speeds of tens and hundreds of gigabits/sec against hundreds of thousand or even millions patterns of signature database, but also change its structure every time a new signature appears or the operating conditions of the protected system change. As a result of the analysis of numerous examples of the development of reconfigurable information security systems, three most promising approaches to the construction of hardware circuits of recognition modules were identified, namely, content-addressable memory based on digital comparators, Bloom filter and Aho–Corasick finite automata. A method for fast quantification of components of recognition module and the entire system was proposed. The method makes it possible to exclude resource-intensive procedures for synthesizing digital circuits on FPGAs when building complex reconfigurable information security systems and their components. To improve the efficiency of the systems under study, structural-level combinational methods are proposed, which allow combining into single recognition device several matching schemes built on different approaches and their modifications, in such a way that their advantages are enhanced and disadvantages are eliminated. In order to achieve the maximum efficiency of combining methods, optimization methods are used. The methods of: parallel combining, sequential cascading and vertical junction have been formulated and investigated. The principle of multi-level combining of combining methods is also considered and researched. Algorithms for the implementation of the proposed combining methods have been developed. Software has been created that allows to conduct experiments with the developed methods and tools. Quantitative estimates are obtained for increasing the efficiency of constructing recognition modules as a result of using combination methods. The issue of optimization of reconfigurable devices presented in hardware description languages is considered. A modification of the method of affine transformations, which allows parallelizing such cycles that cannot be optimized by other methods, was presented. In order to facilitate the practical application of the developed methods and tools, a web service using high-performance computer technologies of grid and cloud computing was considered. The proposed methods to increase efficiency of matching procedure can also be used to solve important problems in other fields of science as data mining, analysis of DNA molecules, etc. Keywords: information security, signature, multi-pattern matching, FPGA, structural combining, efficiency, optimization, hardware description language.
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28

Harte, Liam, ed. The Oxford Handbook of Modern Irish Fiction. Oxford University Press, 2020. http://dx.doi.org/10.1093/oxfordhb/9780198754893.001.0001.

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The Oxford Handbook of Modern Irish Fiction presents authoritative essays by thirty-five distinguished scholars of Irish fiction. Collectively, they provide accessible and incisive assessments of the breadth and achievement of Ireland’s modern novelists and short story writers, whose contribution to the evolution and modification of these unique art forms has been far out of proportion to the country’s small size. The volume brings an impressive variety of critical perspectives to bear on the development of modern Irish fiction, situating authors, texts, and genres in their social, intellectual, and literary-historical contexts. The Handbook’s coverage encompasses an expansive range of topics, including the nature and function of the Irish Gothic mode; nineteenth-century Irish women’s fiction and its influence on emergent modernism and cultural nationalism; the diverse modes of irony, fabulism, and social realism that characterize the fiction of the Irish Literary Revival; the fearless aesthetic radicalism of James Joyce; the jolting narratological experiments of Samuel Beckett, Flann O’Brien, and Máirtín Ó Cadhain; the fate of the realist and modernist traditions in the work of Elizabeth Bowen, Frank O’Connor, Seán O’Faoláin, and Mary Lavin, and in that of their ambivalent heirs, Edna O’Brien, John McGahern, and John Banville; the subversive treatment of sexuality and gender in Northern Irish women’s fiction written during and after the Troubles; the often neglected genres of Irish crime fiction, science fiction, and fiction for children; the many-hued novelistic responses to the experiences of famine, revolution, and emigration; and the variety and vibrancy of post-millennial fiction from both parts of Ireland. Readably written and employing a wealth of original research, The Oxford Handbook of Modern Irish Fiction illuminates a distinguished literary tradition that has altered the shape of world literature.
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29

Diabetes sourcebook: Basic consumer health information about type 1 and type 2 diabetes mellitus, gestational diabetes, monogenic forms of diabetes, and insulin resistance, with guidelines for lifestyle modifications and the medical management of diabetes, including facts about insulin, insulin delivery devices, oral diabetes medications, self-monitoring of blood glucose, meal planning, physical activity recommendations, foot care, and treatment options for people with kidney failure; along with a section about diabetes complications and co-occurring conditions, a glossary of related terms, and directories of resources for additional help and information. 4th ed. Detroit, MI: Omnigraphics, 2008.

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30

Skiba, Grzegorz. Fizjologiczne, żywieniowe i genetyczne uwarunkowania właściwości kości rosnących świń. The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 2020. http://dx.doi.org/10.22358/mono_gs_2020.

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Bones are multifunctional passive organs of movement that supports soft tissue and directly attached muscles. They also protect internal organs and are a reserve of calcium, phosphorus and magnesium. Each bone is covered with periosteum, and the adjacent bone surfaces are covered by articular cartilage. Histologically, the bone is an organ composed of many different tissues. The main component is bone tissue (cortical and spongy) composed of a set of bone cells and intercellular substance (mineral and organic), it also contains fat, hematopoietic (bone marrow) and cartilaginous tissue. Bones are a tissue that even in adult life retains the ability to change shape and structure depending on changes in their mechanical and hormonal environment, as well as self-renewal and repair capabilities. This process is called bone turnover. The basic processes of bone turnover are: • bone modeling (incessantly changes in bone shape during individual growth) following resorption and tissue formation at various locations (e.g. bone marrow formation) to increase mass and skeletal morphology. This process occurs in the bones of growing individuals and stops after reaching puberty • bone remodeling (processes involve in maintaining bone tissue by resorbing and replacing old bone tissue with new tissue in the same place, e.g. repairing micro fractures). It is a process involving the removal and internal remodeling of existing bone and is responsible for maintaining tissue mass and architecture of mature bones. Bone turnover is regulated by two types of transformation: • osteoclastogenesis, i.e. formation of cells responsible for bone resorption • osteoblastogenesis, i.e. formation of cells responsible for bone formation (bone matrix synthesis and mineralization) Bone maturity can be defined as the completion of basic structural development and mineralization leading to maximum mass and optimal mechanical strength. The highest rate of increase in pig bone mass is observed in the first twelve weeks after birth. This period of growth is considered crucial for optimizing the growth of the skeleton of pigs, because the degree of bone mineralization in later life stages (adulthood) depends largely on the amount of bone minerals accumulated in the early stages of their growth. The development of the technique allows to determine the condition of the skeletal system (or individual bones) in living animals by methods used in human medicine, or after their slaughter. For in vivo determination of bone properties, Abstract 10 double energy X-ray absorptiometry or computed tomography scanning techniques are used. Both methods allow the quantification of mineral content and bone mineral density. The most important property from a practical point of view is the bone’s bending strength, which is directly determined by the maximum bending force. The most important factors affecting bone strength are: • age (growth period), • gender and the associated hormonal balance, • genotype and modification of genes responsible for bone growth • chemical composition of the body (protein and fat content, and the proportion between these components), • physical activity and related bone load, • nutritional factors: – protein intake influencing synthesis of organic matrix of bone, – content of minerals in the feed (CA, P, Zn, Ca/P, Mg, Mn, Na, Cl, K, Cu ratio) influencing synthesis of the inorganic matrix of bone, – mineral/protein ratio in the diet (Ca/protein, P/protein, Zn/protein) – feed energy concentration, – energy source (content of saturated fatty acids - SFA, content of polyun saturated fatty acids - PUFA, in particular ALA, EPA, DPA, DHA), – feed additives, in particular: enzymes (e.g. phytase releasing of minerals bounded in phytin complexes), probiotics and prebiotics (e.g. inulin improving the function of the digestive tract by increasing absorption of nutrients), – vitamin content that regulate metabolism and biochemical changes occurring in bone tissue (e.g. vitamin D3, B6, C and K). This study was based on the results of research experiments from available literature, and studies on growing pigs carried out at the Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences. The tests were performed in total on 300 pigs of Duroc, Pietrain, Puławska breeds, line 990 and hybrids (Great White × Duroc, Great White × Landrace), PIC pigs, slaughtered at different body weight during the growth period from 15 to 130 kg. Bones for biomechanical tests were collected after slaughter from each pig. Their length, mass and volume were determined. Based on these measurements, the specific weight (density, g/cm3) was calculated. Then each bone was cut in the middle of the shaft and the outer and inner diameters were measured both horizontally and vertically. Based on these measurements, the following indicators were calculated: • cortical thickness, • cortical surface, • cortical index. Abstract 11 Bone strength was tested by a three-point bending test. The obtained data enabled the determination of: • bending force (the magnitude of the maximum force at which disintegration and disruption of bone structure occurs), • strength (the amount of maximum force needed to break/crack of bone), • stiffness (quotient of the force acting on the bone and the amount of displacement occurring under the influence of this force). Investigation of changes in physical and biomechanical features of bones during growth was performed on pigs of the synthetic 990 line growing from 15 to 130 kg body weight. The animals were slaughtered successively at a body weight of 15, 30, 40, 50, 70, 90, 110 and 130 kg. After slaughter, the following bones were separated from the right half-carcass: humerus, 3rd and 4th metatarsal bone, femur, tibia and fibula as well as 3rd and 4th metatarsal bone. The features of bones were determined using methods described in the methodology. Describing bone growth with the Gompertz equation, it was found that the earliest slowdown of bone growth curve was observed for metacarpal and metatarsal bones. This means that these bones matured the most quickly. The established data also indicate that the rib is the slowest maturing bone. The femur, humerus, tibia and fibula were between the values of these features for the metatarsal, metacarpal and rib bones. The rate of increase in bone mass and length differed significantly between the examined bones, but in all cases it was lower (coefficient b <1) than the growth rate of the whole body of the animal. The fastest growth rate was estimated for the rib mass (coefficient b = 0.93). Among the long bones, the humerus (coefficient b = 0.81) was characterized by the fastest rate of weight gain, however femur the smallest (coefficient b = 0.71). The lowest rate of bone mass increase was observed in the foot bones, with the metacarpal bones having a slightly higher value of coefficient b than the metatarsal bones (0.67 vs 0.62). The third bone had a lower growth rate than the fourth bone, regardless of whether they were metatarsal or metacarpal. The value of the bending force increased as the animals grew. Regardless of the growth point tested, the highest values were observed for the humerus, tibia and femur, smaller for the metatarsal and metacarpal bone, and the lowest for the fibula and rib. The rate of change in the value of this indicator increased at a similar rate as the body weight changes of the animals in the case of the fibula and the fourth metacarpal bone (b value = 0.98), and more slowly in the case of the metatarsal bone, the third metacarpal bone, and the tibia bone (values of the b ratio 0.81–0.85), and the slowest femur, humerus and rib (value of b = 0.60–0.66). Bone stiffness increased as animals grew. Regardless of the growth point tested, the highest values were observed for the humerus, tibia and femur, smaller for the metatarsal and metacarpal bone, and the lowest for the fibula and rib. Abstract 12 The rate of change in the value of this indicator changed at a faster rate than the increase in weight of pigs in the case of metacarpal and metatarsal bones (coefficient b = 1.01–1.22), slightly slower in the case of fibula (coefficient b = 0.92), definitely slower in the case of the tibia (b = 0.73), ribs (b = 0.66), femur (b = 0.59) and humerus (b = 0.50). Bone strength increased as animals grew. Regardless of the growth point tested, bone strength was as follows femur > tibia > humerus > 4 metacarpal> 3 metacarpal> 3 metatarsal > 4 metatarsal > rib> fibula. The rate of increase in strength of all examined bones was greater than the rate of weight gain of pigs (value of the coefficient b = 2.04–3.26). As the animals grew, the bone density increased. However, the growth rate of this indicator for the majority of bones was slower than the rate of weight gain (the value of the coefficient b ranged from 0.37 – humerus to 0.84 – fibula). The exception was the rib, whose density increased at a similar pace increasing the body weight of animals (value of the coefficient b = 0.97). The study on the influence of the breed and the feeding intensity on bone characteristics (physical and biomechanical) was performed on pigs of the breeds Duroc, Pietrain, and synthetic 990 during a growth period of 15 to 70 kg body weight. Animals were fed ad libitum or dosed system. After slaughter at a body weight of 70 kg, three bones were taken from the right half-carcass: femur, three metatarsal, and three metacarpal and subjected to the determinations described in the methodology. The weight of bones of animals fed aa libitum was significantly lower than in pigs fed restrictively All bones of Duroc breed were significantly heavier and longer than Pietrain and 990 pig bones. The average values of bending force for the examined bones took the following order: III metatarsal bone (63.5 kg) <III metacarpal bone (77.9 kg) <femur (271.5 kg). The feeding system and breed of pigs had no significant effect on the value of this indicator. The average values of the bones strength took the following order: III metatarsal bone (92.6 kg) <III metacarpal (107.2 kg) <femur (353.1 kg). Feeding intensity and breed of animals had no significant effect on the value of this feature of the bones tested. The average bone density took the following order: femur (1.23 g/cm3) <III metatarsal bone (1.26 g/cm3) <III metacarpal bone (1.34 g / cm3). The density of bones of animals fed aa libitum was higher (P<0.01) than in animals fed with a dosing system. The density of examined bones within the breeds took the following order: Pietrain race> line 990> Duroc race. The differences between the “extreme” breeds were: 7.2% (III metatarsal bone), 8.3% (III metacarpal bone), 8.4% (femur). Abstract 13 The average bone stiffness took the following order: III metatarsal bone (35.1 kg/mm) <III metacarpus (41.5 kg/mm) <femur (60.5 kg/mm). This indicator did not differ between the groups of pigs fed at different intensity, except for the metacarpal bone, which was more stiffer in pigs fed aa libitum (P<0.05). The femur of animals fed ad libitum showed a tendency (P<0.09) to be more stiffer and a force of 4.5 kg required for its displacement by 1 mm. Breed differences in stiffness were found for the femur (P <0.05) and III metacarpal bone (P <0.05). For femur, the highest value of this indicator was found in Pietrain pigs (64.5 kg/mm), lower in pigs of 990 line (61.6 kg/mm) and the lowest in Duroc pigs (55.3 kg/mm). In turn, the 3rd metacarpal bone of Duroc and Pietrain pigs had similar stiffness (39.0 and 40.0 kg/mm respectively) and was smaller than that of line 990 pigs (45.4 kg/mm). The thickness of the cortical bone layer took the following order: III metatarsal bone (2.25 mm) <III metacarpal bone (2.41 mm) <femur (5.12 mm). The feeding system did not affect this indicator. Breed differences (P <0.05) for this trait were found only for the femur bone: Duroc (5.42 mm)> line 990 (5.13 mm)> Pietrain (4.81 mm). The cross sectional area of the examined bones was arranged in the following order: III metatarsal bone (84 mm2) <III metacarpal bone (90 mm2) <femur (286 mm2). The feeding system had no effect on the value of this bone trait, with the exception of the femur, which in animals fed the dosing system was 4.7% higher (P<0.05) than in pigs fed ad libitum. Breed differences (P<0.01) in the coross sectional area were found only in femur and III metatarsal bone. The value of this indicator was the highest in Duroc pigs, lower in 990 animals and the lowest in Pietrain pigs. The cortical index of individual bones was in the following order: III metatarsal bone (31.86) <III metacarpal bone (33.86) <femur (44.75). However, its value did not significantly depend on the intensity of feeding or the breed of pigs.
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