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Bower, Julienne E., Patricia A. Ganz, Katherine A. Desmond, Julia H. Rowland, Beth E. Meyerowitz, and Thomas R. Belin. "Fatigue in Breast Cancer Survivors: Occurrence, Correlates, and Impact on Quality of Life." Journal of Clinical Oncology 18, no. 4 (February 14, 2000): 743. http://dx.doi.org/10.1200/jco.2000.18.4.743.
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PURPOSE: To describe the occurrence of fatigue in a large sample of breast cancer survivors relative to general population norms and to identify demographic, medical, and psychosocial characteristics of fatigued survivors. PATIENTS AND METHODS: Breast cancer survivors in two large metropolitan areas completed standardized questionnaires as part of a survey study, including the RAND 36-item Health Survey, Center for Epidemiological Studies–Depression Scale, Breast Cancer Prevention Trial Symptom Checklist, Medical Outcomes Study Sleep Scale, and demographic and treatment-related measures. RESULTS: On average, the level of fatigue reported by the breast cancer survivors surveyed (N = 1,957) was comparable to that of age-matched women in the general population, although the breast cancer survivors were somewhat more fatigued than a more demographically similar reference group. Approximately one third of the breast cancer survivors assessed reported more severe fatigue, which was associated with significantly higher levels of depression, pain, and sleep disturbance. In addition, fatigued women were more bothered by menopausal symptoms and were somewhat more likely to have received chemotherapy (with or without radiation therapy) than nonfatigued women. In multivariate analyses, depression and pain emerged as the strongest predictors of fatigue. CONCLUSION: Although the majority of breast cancer survivors in this large and diverse sample did not experience heightened levels of fatigue relative to women in the general population, there was a subgroup of survivors who did report more severe and persistent fatigue. We identified characteristics of these women that may be helpful in elucidating the mechanisms underlying fatigue in this population, as well as directing intervention efforts.
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Gardner, Diane L. "Fatigue in postpartum women." Applied Nursing Research 4, no. 2 (May 1991): 57–62. http://dx.doi.org/10.1016/s0897-1897(05)80056-4.
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Canário, Ana Carla Gomes, Patricia Uchoa Leitão Cabral, Lucila Corsino de Paiva, Gilzandra Lira Dantas Florencio, Maria Helena Spyrides, and Ana Katherine da Silveira Gonçalves. "Physical activity, fatigue and quality of life in breast cancer patients." Revista da Associação Médica Brasileira 62, no. 1 (February 2016): 38–44. http://dx.doi.org/10.1590/1806-9282.62.01.38.
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SUMMARY Objective: to evaluate the relationship between levels of physical activity, fatigue and quality of life (QOL) in women diagnosed with breast cancer. Methods: 215 women between the ages of 40 and 65 years were recruited at a cancer clinic. Physical activity levels were assessed by using the International Physical Activity Questionnaire (IPAQ), fatigue levels by using the revised Piper scale, and QOL by means of EORTC QLQ-C30 and WHOQOL-Bref. Statistical analysis was performed using Minitab statistical software, version 16. Results: the mean age of subjects was 52.66 years (SD=8.6); patients were mostly white (58.14%) and overweight (55.81%). Most women were fatigued (72.09%) while physically active women showed lower symptoms of fatigue (p<0.001). Mean scores for QOL were significantly lower among fatigued women (p<0.001). More active women scored higher on all scales of QOL (EORTC), especially for functional capacity (p<0.001), compared with the sedentary patients. A significant association was found between level of physical activity and overall QOL (WHOQOL-Bref) for all domains (p<0.001). Climacteric symptoms ranged from mild to strong and did not show any statistically significant results; however, the most active women had the fewest symptoms. Conclusion: physical activity appears to positively influence fatigue and QOL in women diagnosed with breast cancer.
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Mathis, Bryan. "The Intricate Web of Fatigue in Women." Women 1, no. 4 (December 1, 2021): 267–79. http://dx.doi.org/10.3390/women1040023.
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The modern woman has taken her rightful place in society as a worker, a caregiver, a mother, and a world citizen. However, along with the privileges of these roles comes the great cost of stress and resultant exhaustion and fatigue. Psychosocial, physical, cultural, and disease-related realms of stress act as strands of a web that serve to bind and hinder women with chronic stress. New areas of research, such as exercise intervention, improved social programs (e.g., childcare), and supplementation are constantly evaluated for effectiveness alongside traditional remedies such as exercise. This review will highlight some of the key issues regarding stress in women and explore reports of new treatment modalities in light of the specific requirements of the modern woman.
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Libbus, M. Kay, Janet L. Baker, Jean M. Osgood, Theresa C. Phillips, and Diane M. Valentine. "Persistent Fatigue in Well Women." Women & Health 23, no. 1 (August 4, 1995): 57–72. http://dx.doi.org/10.1300/j013v23n01_04.
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Fuhrer, Rebecca, and Simon Wessely. "The epidemiology of fatigue and depression: a French primary-care study." Psychological Medicine 25, no. 5 (September 1995): 895–905. http://dx.doi.org/10.1017/s0033291700037387.
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SYNOPSISThe prevalence of fatigue as a presenting complaint and as a symptom is evaluated in French general practice patients. The data for a sample of 3784 persons 18–64 years-of-age who were seen by 367 general practitioners were examined for fatigue as a presenting complaint, diagnosis, and reported symptoms of persistent fatigue. Gender, age, and socio-professional category were considered as potential risk correlates. At least one of the symptoms of persistent fatigue was reported by 41·2% of the patients, but only 7·6% had presented with fatigue to the doctor. Women reported more symptoms of fatigue than men, but they were only slightly more likely to present with, or be diagnosed with fatigue; women were more frequently diagnosed with depression. There was a strong relationship between the symptoms of depression as measured by the Center for Epidemiologic Studies – Depression Scale (CES-D) and fatigue, but fatigue was neither sensitive nor specific for the diagnosis of depression. Age and fatigue as a presenting complaint and diagnosis were strongly associated for men. After adjusting for sex and age, we found that lower social classes were less likely to be diagnosed as fatigued, though they were more likely to report symptoms of fatigue.
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Kent-Braun, J. A., A. V. Ng, J. W. Doyle, and T. F. Towse. "Human skeletal muscle responses vary with age and gender during fatigue due to incremental isometric exercise." Journal of Applied Physiology 93, no. 5 (November 1, 2002): 1813–23. http://dx.doi.org/10.1152/japplphysiol.00091.2002.
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The purpose of this study was to compare the magnitude and mechanisms of ankle dorsiflexor muscle fatigue in 20 young (33 ± 6 yr, mean ± SD) and 21 older (75 ± 6 yr) healthy men and women of similar physical activity status. Noninvasive measures of central and peripheral (neuromuscular junction, sarcolemma) muscle activation, muscle contractile function, and intramuscular energy metabolism were made before, during, and after incremental isometric exercise. Older subjects fatigued less than young ( P < 0.01); there was no effect of gender on fatigue ( P = 0.24). For all subjects combined, fatigue was modestly related to preexercise strength ( r = 0.49, P < 0.01). Neither central (central activation ratio) nor peripheral (compound muscle action potential) activation played a significant role in fatigue in any group. During exercise, intracellular concentrations of Piand H2PO[Formula: see text] increased more and pH fell more in young compared with older subjects ( P < 0.01) and in men compared with women ( P < 0.01). These varied metabolic responses to exercise suggest a greater reliance on nonoxidative sources of ATP in young compared with older subjects and in men compared with women. These results suggest that the mechanisms of fatigue vary with age and gender, regardless of whether differences in the magnitude of fatigue are observed.
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Melkani, Ekta, Manju Mehta, and Sudesh Gandhi. "Drudgery Reduction and Grip Fatigue Review of Indian Women Making Handicrafts." Asian Pacific Journal of Health Sciences 7, no. 2 (June 2020): 54–57. http://dx.doi.org/10.21276/apjhs.2020.7.2.13.
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S., Deepa, Kumaresan A., Prathap Suganthirababu, and Surya Vishnuram. "Correlation of biomarker cortisol with fatigue and quality of life among men and women with idiopathic Parkinson’s disease." Biomedicine 42, no. 4 (September 12, 2022): 812–16. http://dx.doi.org/10.51248/.v42i4.1577.
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Introduction and Aim: Fatigue is the prodromal symptom occurring as the earliest symptom even before motor symptoms. It has been unidentified, which also proves to be an untouched symptom for intervention. Little has been understood how men and women feel fatigued. The objective of this study is to find the correlation between fatigue and quality of life among men and women with idiopathic Parkinson’s disease (PD). Materials and Methods: Recommended scale for fatigue as fatigue severity score and a biomarker salivary cortisol was correlated against the quality-of-life questionnaire as PDQ-39 among 25 PD male and female patients. Results: Females are found to show significantly higher values compared to males in PDQ and salivary cortisol. F values are significant for PDQ and salivary cortisol only (p < 0.01) when compared to the H/Y scale (‘r’ = 0.420). Conclusion: Females reported more fatigue and poor quality of life. Salivary cortisol can be a useful biomarker to measure and infer the level of fatigue which had been only feeling reported by the patients until now.
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김영희 and Okhee Cho. "Factors Influencing Fatigue in Pregnant Women." JOURNAL OF THE KOREAN SOCIETY OF MATERNAL AND CHILD HEALTH 16, no. 1 (January 2012): 80–88. http://dx.doi.org/10.21896/jksmch.2012.16.1.80.
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Dzurec, Laura Cox, Phyllis M. Hoover, and Jonathan Fields. "Acknowledging Unexplained Fatigue of Tired Women." Journal of Nursing Scholarship 34, no. 1 (March 2002): 41–46. http://dx.doi.org/10.1111/j.1547-5069.2002.00041.x.
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Taylor, Jan, and Maree Johnson. "How women manage fatigue after childbirth." Midwifery 26, no. 3 (June 2010): 367–75. http://dx.doi.org/10.1016/j.midw.2008.07.004.
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Cahill, Cheryl A. "Differential Diagnosis of Fatigue in Women." Journal of Obstetric, Gynecologic & Neonatal Nursing 28, no. 1 (January 1999): 81–86. http://dx.doi.org/10.1111/j.1552-6909.1999.tb01968.x.
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Hunter, Gary R., William H. Neumeier, C. Scott Bickel, John P. McCarthy, Gordon Fisher, Paula C. Chandler-Laney, and Stephen P. Glasser. "Arterial Elasticity, Strength, Fatigue, and Endurance in Older Women." BioMed Research International 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/501754.
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Arterial health may influence muscle function in older adults. Study purpose was to determine whether arterial elasticity is related to strength, central and peripheral fatigue, fatigue at rest, and treadmill endurance. Subjects were 91 healthy women aged >60. Treadmill endurance and maximal oxygen uptake (VO2max) were measured. Peripheral and central fatigue for the knee extensors were evaluated using two isometric fatigue tests (one voluntary and one adding electrical stimulation). Arterial elasticity was determined using radial artery pulse wave analysis. Linear multiple regression was used in statistical analysis. Large artery elasticity was associated with central fatigue(P<0.01)and treadmill endurance(P<0.02)after adjusting for VO2max and knee extension strength. Subjective fatigue at rest was related to large artery elasticity after adjusting for ethnic origin (<0.02). Strength was significantly related to small artery elasticity after adjusting for ethnic origin, leg lean tissue, age, and blood pressure. Arterial elasticity is independently related to strength and fatigue in older women, especially in the central nervous system where arterial elasticity is independently related to perceptions of fatigue at rest and central fatigue. These results suggest that arterial health may be involved with the ability of the central nervous system to activate muscle in older women.
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Hunter, Sandra K., Jane E. Butler, Gabrielle Todd, Simon C. Gandevia, and Janet L. Taylor. "Supraspinal fatigue does not explain the sex difference in muscle fatigue of maximal contractions." Journal of Applied Physiology 101, no. 4 (October 2006): 1036–44. http://dx.doi.org/10.1152/japplphysiol.00103.2006.
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Young women are less fatigable than young men for maximal and submaximal contractions, but the contribution of supraspinal fatigue to the sex difference is not known. This study used cortical stimulation to compare the magnitude of supraspinal fatigue during sustained isometric maximal voluntary contractions (MVCs) performed with the elbow flexor muscles of young men and women. Eight women (25.6 ± 3.6 yr, mean ± SD) and 9 men (25.4 ± 3.8 yr) performed six sustained MVCs (22-s duration each, separated by 10 s). Before the fatiguing contractions, the men were stronger than the women (75.9 ± 9.2 vs. 42.7 ± 8.0 N·m; P < 0.05) in control MVCs. Voluntary activation measured with cortical stimulation before fatigue was similar for the men and women during the final control MVC (95.7 ± 3.0 vs. 93.3 ± 3.6%; P > 0.05) and at the start of the fatiguing task ( P > 0.05). By the end of the six sustained fatiguing MVCs, the men exhibited greater absolute and relative reductions in torque (65 ± 3% of initial MVC) than the women (52 ± 9%; P < 0.05). The increments in torque (superimposed twitch) generated by motor cortex stimulation during each 22-s maximal effort increased with fatigue ( P < 0.05). Superimposed twitches were similar for men and women throughout the fatiguing task (5.5 ± 4.1 vs. 7.3 ± 4.7%; P > 0.05), as well as in the last sustained contraction (7.8 ± 5.9 vs. 10.5 ± 5.5%) and in brief recovery MVCs. Voluntary activation determined using an estimated control twitch was similar for the men and women at the start of the sustained maximal contractions (91.4 ± 7.4 vs. 90.4 ± 6.8%, n = 13) and end of the sixth contraction (77.2 ± 13.3% vs. 73.1 ± 19.6%, n = 10). The increase in the area of the motor-evoked potential and duration of the silent period did not differ for men and women during the fatiguing task. However, estimated resting twitch amplitude and the peak rates of muscle relaxation showed greater relative reductions at the end of the fatiguing task for the men than the women. These results indicate that the sex difference in fatigue of the elbow flexor muscles is not explained by a difference in supraspinal fatigue in men and women but is largely due to a sex difference of mechanisms located within the elbow flexor muscles.
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Estévez-López, Fernando, María Rodriguez-Ayllon, Alberto Soriano-Maldonado, Pedro Acosta-Manzano, Víctor Segura-Jiménez, Inmaculada C. Álvarez-Gallardo, Manuel Pulido-Martos, et al. "Lower Fatigue in Fit and Positive Women with Fibromyalgia: The al-Ándalus Project." Pain Medicine 20, no. 12 (January 29, 2019): 2506–15. http://dx.doi.org/10.1093/pm/pny304.
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Abstract Objective To analyze 1) the independent association of physical fitness, positive affect, and negative affect with the different dimensions of fatigue (general fatigue, physical fatigue, reduced activity, reduced motivation, and mental fatigue) and 2) whether the interactions of physical fitness, positive affect, and negative affect were associated with fatigue over and above the independent association. Design Cross-sectional study in 420 women with fibromyalgia. Setting Fibromyalgia associations from southern Spain. Methods Physical fitness was measured by performance-based tests, and questionnaires were used to measure positive affect, negative affect, and different dimensions of fatigue (general fatigue, physical fatigue, reduced activity, reduced motivation, and mental fatigue). Age, body mass index, and current pain level were included as potential confounders in all analyses. Results Physical fitness was independently associated with general fatigue, physical fatigue, and reduced activity (all P ≤ 0.02). Positive affect was independently associated with all fatigue dimensions (all P < 0.001). Negative affect was independently associated with general fatigue, physical fatigue, reduced motivation, and mental fatigue (all P ≤ 0.04). The interaction of overall physical fitness and positive affect was related to general fatigue and physical fatigue (all P ≤ 0.02). Women with fibromyalgia with higher levels of overall physical fitness and positive affect showed the lowest general fatigue and physical fatigue. Conclusions In women with fibromyalgia, positive affect was independently and consistently associated with all dimensions of fatigue. The combination of higher levels of overall physical fitness and positive affect might serve as a buffer against general and physical fatigue in women with fibromyalgia.
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Henderson, Jane, Fiona Alderdice, and Maggie Redshaw. "Factors associated with maternal postpartum fatigue: an observationalstudy." BMJ Open 9, no. 7 (July 2019): e025927. http://dx.doi.org/10.1136/bmjopen-2018-025927.
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ObjectivesTo assess the prevalence of postpartum fatigue at 10 days, 1 month and 3 months, and to describe the sociodemographic and clinical characteristics of women with fatigue and the associations with infant characteristics, maternal–infant attachment, and partner and midwifery support.SettingMaternity care in England. Secondary analysis of 2014 National Maternity Survey.ParticipantsParticipants were a random sample of 10 000 women selected by the Office for National Statistics using birth registration records. Women aged less than 16 years or if their baby had died were excluded. Questionnaires were sent to women at 3 months post partum and asked about well-being and care during pregnancy, labour, birth and post partum. Specifically, women were asked whether they experienced fatigue/severe tiredness at 10 days, 1 month or 3 months post partum. Responses were received from 4578 women (47% response rate).ResultsDecreasing but substantial proportions of women, 38.8%, 27.1% and 11.4%, experienced fatigue/severe tiredness at 10 days, 1 month and 3 months, respectively. These figures varied significantly by maternal age, level of deprivation, education and parity. Women reporting depression, anxiety, sleep problems and those breast feeding were at significantly increased risk (eg, OR for depression in women with fatigue at 3 months: 2.99 (95% CI 2.13 to 4.21)). Significantly more negative language was used by these women to describe their babies, and they perceived their baby as more difficult than average (eg, two or more negative adjectives used by women with fatigue at 3 months: OR 1.86 (95% CI 1.36 to 2.54)). Women with postpartum fatigue had greater partner support but were significantly less likely to report seeing the midwife as much as they wanted.ConclusionsPostpartum fatigue is not inevitable or universal, although early in the postnatal period it affects a substantial proportion of women. Predictors include age and parity, but practical help and support from partners and midwives may be protective factors.
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Jeong, Hwee-soo. "THE STATUS OF HAIR MINERALS IN CHRONIC FATIGUE AND DEPRESSED WOMEN." Asian Journal of Pharmaceutical and Clinical Research 11, no. 11 (November 7, 2018): 485. http://dx.doi.org/10.22159/ajpcr.2018.v11i11.29335.
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Objective: Chronic fatigue and depression are common problems in primary care. The status of micronutrients may be related to two conditions. The present study aimed to identify the association of minerals with chronic fatigue and depression.Methods: We conducted a cross-sectional study using medical records of 97 female patients aged 20–64 years old who visited the integrated medical center of a university hospital in Gyeongju, South Korea, from 2013 to 2016. Collected information comprised their scores for the fatigue severity scale, beck depression inventory, and concentrations of mineral in hair samples.Results: The subjects were classified into three groups according to their depression and fatigue scores: 21 patients (21.6%) were free of fatigue and depression, 55 (56.8%)experienced fatigue without depression, and 21 (21.6%) experienced fatigue with depression. The potassium (K) concentration in hair significantly decreased in the groups of fatigue or fatigue with depression compared to the group with free of fatigue and depression (p=0.042). The trend of sodium (Na), K concentration, and Na/magnesium (Mg) ratios in hair gradually decreased with fatigue and depression (p for trend=0.027, 0.037, and 0.03).Conclusion: Chronic fatigue and depression in women are associated with the concentrations of hair minerals, especially Na, K, and Na/Mg ratios.
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Torres, Mylin Ann, Thaddeus Pace, Jennifer Felger, Tian Liu, Karen D. Godette, Liza Jane Stapleford, Donna Mister, and Andrew H. Miller. "A prospective longitudinal study of cancer-related fatigue in patients undergoing breast-conserving surgery and radiation with or without chemotherapy for breast cancer." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): 9122. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.9122.
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9122 Background: We prospectively evaluated risk factors for persistent cancer-related fatigue in women with breast cancer undergoing lumpectomy with or without chemotherapy (CTX) prior to whole breast radiotherapy (XRT). We assessed the potential role of inflammatory mediators, demographic characteristics, and treatment history including CTX. Methods: Following lumpectomy, 60 women received a definitive course of whole breast XRT (50 Gy plus a 10 Gy boost). Prior to XRT, at week 6 of XRT, and 6 weeks post XRT, subjects completed the Multidimensional Fatigue Inventory (MFI) and underwent blood draws for inflammatory mediators (protein and mRNA). Results: Independent multivariate analyses of clinical and demographic factors revealed that CTX (p<.001) , given neoadjuvantly or adjuvantly, and age <50 (p=.03) were significant predictors of higher fatigue scores post XRT. Mean MFI scores in patients treated with CTX (n=24) were 20 points higher than patients not treated with CTX (p<.001) with a clinically meaningful difference in scores being 10 points on the MFI. Gene ontology analysis of differentially expressed genes indicated increased activation of genes involved in immune and inflammatory responses in fatigued vs. non-fatigued patients (p<.001). Of the inflammatory mediators, plasma IL-6 prior to XRT was the strongest predictor of post XRT fatigue (p=.02). Moreover, plasma IL-6 concentrations prior to XRT were significantly higher in patients who received CTX (mean 4.96 vs. 2.53, p=.01). Patients who received CTX also had significantly higher levels of NF Kappa B DNA binding 6 weeks post XRT (p<.001), and transcription factor binding analysis revealed a greater representation of genes with the NF Kappa B DNA binding motif in fatigued vs. non-fatigued patients (p =.05). Conclusions: Collectively, these data suggest an interaction between CTX and XRT leading to inflammation and fatigue several weeks post XRT. This relationship was independent of whether CTX was given pre or post-operatively. Treatments targeting inflammation before XRT may reduce fatigue post therapy, particularly in patients previously treated with CTX.
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McBean, Amanda L., and Hawley E. Montgomery-Downs. "Diurnal Fatigue Patterns, Sleep Timing, and Mental Health Outcomes Among Healthy Postpartum Women." Biological Research For Nursing 17, no. 1 (March 24, 2014): 29–39. http://dx.doi.org/10.1177/1099800414528278.
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Postpartum women have frequently interrupted sleep, report high levels of fatigue, and may experience circadian rhythm disruptions. They are also susceptible to mood impairments, anxiety, and stress. The current study explored associations between maternal postpartum daily fatigue patterns, which should vary according to circadian influences and mental health. Seventy-one primiparous, healthy mothers completed multiple daily self-reports of fatigue during postpartum Weeks 2 and 12 and were categorized at each week as having either a rhythmic or random fatigue pattern during the daytime. Wrist actigraphy data were used to calculate sleep midpoints. Surveys assessed chronotype, mood, anxiety, and stress. At postpartum Week 2, there were no differences in mental health measures between fatigue groups. At postpartum Week 12, higher overall fatigue levels were associated with increased anxiety, stress, and mood disruption. However, overall fatigue levels did not differ between fatigue groups. Women with a rhythmic fatigue pattern reported significantly less stress and more vigor than women with a random fatigue pattern. An earlier sleep midpoint was associated with a rhythmic fatigue pattern during postpartum Week 12. These data suggest that, despite similar average daily fatigue levels, having a rhythmic daily pattern of fatigue may be advantageous for mental health outcomes among postpartum women.
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Schaefer, Karen Moore. "Sleep Disturbances and Fatigue in Women With Fibromyalgia and Chronic Fatigue Syndrome." Journal of Obstetric, Gynecologic & Neonatal Nursing 24, no. 3 (March 1995): 229–33. http://dx.doi.org/10.1111/j.1552-6909.1995.tb02467.x.
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Broeckel, J. A., P. B. Jacobsen, J. Horton, L. Balducci, and G. H. Lyman. "Characteristics and correlates of fatigue after adjuvant chemotherapy for breast cancer." Journal of Clinical Oncology 16, no. 5 (May 1998): 1689–96. http://dx.doi.org/10.1200/jco.1998.16.5.1689.
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PURPOSE Clinical reports suggest that many breast cancer patients experience persistent fatigue as a long-term side effect of adjuvant chemotherapy treatment. To investigate this issue further, we examined the characteristics and correlates of fatigue in women who had completed adjuvant chemotherapy for breast cancer and in a comparison group of women with no history of cancer. PATIENTS AND METHODS Participants were 61 women with breast cancer who had completed chemotherapy an average of 471 days previously and 59 women with no history of cancer. All participants completed standardized self-report measures of fatigue, sleep quality, menopausal symptoms, and coping and were administered a structured clinical interview to identify current and past psychiatric disorder. RESULTS Compared with women with no history of cancer, former adjuvant chemotherapy patients reported more severe fatigue (P < .01) and worse quality of life because of fatigue (P < .05). More severe fatigue among patients was significantly (P < .05) related to poorer sleep quality, more menopausal symptoms, greater use of catastrophizing as a coping strategy, and current presence of a psychiatric disorder. CONCLUSION These findings support the view that many breast cancer patients experienced heightened fatigue after completion of adjuvant chemotherapy treatment. Results yield a profile of women who are at increased risk for heightened fatigue after chemotherapy and suggest ways to intervene clinically to prevent or reduce fatigue in this patient population.
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Sakai, K. "Strategy for reducing fatigue in women workers." Sangyo Igaku 34, no. 7 (1992): 658–59. http://dx.doi.org/10.1539/joh1959.34.658.
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Milne, David. "Fatigue Linked to Depression In Postpartum Women." Psychiatric News 41, no. 7 (April 7, 2006): 26. http://dx.doi.org/10.1176/pn.41.7.0026.
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Fritschi, Cynthia, Laurie Quinn, Eileen D. Hacker, Sue M. Penckofer, Edward Wang, Marquis Foreman, and Carol E. Ferrans. "Fatigue in Women With Type 2 Diabetes." Diabetes Educator 38, no. 5 (June 19, 2012): 662–72. http://dx.doi.org/10.1177/0145721712450925.
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Plach, Sandra K., Susan M. Heidrich, and Lee Jeske. "Fatigue representations in women with heart failure." Research in Nursing & Health 29, no. 5 (2006): 452–64. http://dx.doi.org/10.1002/nur.20156.
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Hsieh, Ching-Hsing, Chien-Lan Chen, Feng-Fang Chung, and Su-Ying Lin. "Efficacy of Warm Showers on Postpartum Fatigue Among Vaginal-Birth Taiwanese Women: A Quasi-Experimental Design." Research and Theory for Nursing Practice 31, no. 2 (2017): 96–106. http://dx.doi.org/10.1891/1541-6577.31.2.96.
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Background and Purpose: Postpartum fatigue is one of the most common complaints among women following childbirth. As a postpartum ritual practice, Taiwanese women refrain from taking showers while “doing the month.” However, warm showers are the systemic application of moist heat, and they maintain physical hygiene, stimulate blood circulation, mitigate discomfort, and provide relaxation. As Taiwanese society becomes increasingly receptive to scientific and contemporary health care practice, more and more women choose to take warm showers after childbirth. The purpose of this study was to evaluate the efficacy of warm showers on postpartum fatigue among vaginal-birth women in Taiwan. Methods: This was a two-group quasi-experimental design. Women took showers in warm water with temperatures ranging between 40 °C and 43 °C for approximately 20 minutes. Postpartum women’s fatigue is measured using the 10-item Postpartum Fatigue Scale (PFS). The intervention effect was analyzed using a generalized estimating equation (GEE) model. Results: The study population consisted of 358 vaginal-birth postpartum Taiwanese women aged 20–43 years. Postpartum women who took warm showers showed improvements from their pretest to posttest mean scores of postpartum fatigue compared to postpartum women who did not take warm showers. Warm showers helped to reduce postpartum fatigue among vaginal-birth women during the study period. Implications for Practice: Nurses have the unique opportunity to provide the intervention to Taiwanese women who have vaginal birth to help them relieve postpartum fatigue with warm showers while “doing the month” without the taboo of no-showering customary practices in the early postpartum period.
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Loge, Jon Håvard, Arne Foss Abrahamsen, Øivind Ekeberg, and Stein Kaasa. "Hodgkin's Disease Survivors More Fatigued Than the General Population." Journal of Clinical Oncology 17, no. 1 (January 1999): 253. http://dx.doi.org/10.1200/jco.1999.17.1.253.
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PURPOSE: To estimate the level of fatigue and frequency of fatigue cases among Hodgkin's disease survivors (HDS) and compare them with normative data from the general population. PATIENTS AND METHODS: A cross-sectional follow-up study was done of 557 HDS (age range, 19 to 74 years) treated at the Norwegian Radium Hospital from 1971 to 1991. The sample was approached by mail, and their data were compared with normative data from 2,214 controls (age range, 19 to 74 years) representative of the general Norwegian population. Of the 557 HDS, 459 (82%) responded. The mean age (± SD) at the time of study was 44 ± 12 years, and the mean observation time was 12 ± 6 years. The Fatigue Questionnaire (11 items) measures physical and mental fatigue. Two systems of scoring were used, dichotomized (0, 0, 1, and 1) and Likert (0, 1, 2, and 3). Total fatigue (TF) constitutes the sum of all the Likert scores. Caseness was defined as a total dichotomized score of ≥4 and fatigue that lasted 6 months or longer. RESULTS: The HDS had significantly higher levels of TF than the controls (14.3 v 12.2) (P < .001). Fatigue among the HDS equaled that of the controls in poorest health. More HDS (61%) than controls (31%) reported fatigue symptoms lasting 6 months or longer (P < .001). Fatigue cases were more frequent among HDS (men, 24%; women, 27%) than among the controls (men, 9%; women, 12%) (P < .001). Disease stage/substage IB/IIB predicted fatigue caseness (P = .03). No significant associations were found between treatment characteristics and fatigue. CONCLUSION: Hodgkin's disease survivors are considerably more fatigued than the general population and report fatigue of a substantially longer duration.
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olde Hartman, Tim C., Tomas P. Scheepers, Peter Lucassen, and Kees van Boven. "Do Women With Severe Persistent Fatigue Present With Fatigue at the Primary Care Consultation?" Zeitschrift für Psychologie 228, no. 2 (May 2020): 93–99. http://dx.doi.org/10.1027/2151-2604/a000402.
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Abstract. Recent studies have shown underdiagnosis of severe persistent fatigue in primary care. To study how patients with severe persistent fatigue present in primary care and whether they differ from patients with less severe fatigue and patients with no fatigue. A 4-year retrospective database study combined with a questionnaire, including all female patients 25–50 years ( n = 917) who are registered in one primary care group practice. Based on the results of a validated self-administered questionnaire, patients were divided into three groups: patients with severe persistent fatigue ( n = 42), patients with fatigue ( n = 174), and patients with no fatigue ( n = 246). Data on frequency of consulting, reason for encounter, and diagnoses from 2009 to 2013 were obtained from the electronic medical health record. Data were analyzed using odds ratios. Women with severe persistent fatigue more often were unemployed and had lower education. They visited the general practitioners (GP) more often than other women. However, more than half of the women with severe persistent fatigue did not visit their GP with fatigue as reason for encounter at all during the 4 years of study. A minority of the women with severe persistent fatigue received a psychological diagnosis or social diagnosis (36% and 19%, respectively) during these 4 years. Underdiagnosis of severe persistent fatigue is partly a consequence of patients not presenting or reporting this to their GP. The reasons for this behavior are not clear.
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Zhu, Xiaoxiao, and Haiou Xia. "Trajectory patterns and factors influencing perinatal fatigue among Chinese women from late pregnancy to 6 months after delivery." PeerJ 10 (May 26, 2022): e13387. http://dx.doi.org/10.7717/peerj.13387.
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Background Perinatal fatigue among women is related to the clinical outcomes of mothers and infants. Perinatal fatigue changes over time, and the trajectory varies according to the predictors and outcomes of the mothers. This, however, has not been documented in any study. Objectives This study aimed to identify and characterize the trajectory patterns of perinatal fatigue among women from late pregnancy to 6 months after delivery. Methods We used growth mixture modeling to estimate the trajectory of perinatal fatigue at 28 gestational weeks (T0), 37 gestational weeks (T1), 3 days (T2), 1 week (T3), 6 weeks (T4), and 6 months (T5) after delivery with (n = 1,030). The Mann-Whitney U test and binary logistic regression were used to tie the selected trajectory classes to predictors and outcomes. Results There were two distinct patterns of perinatal fatigue in women: “persistently high” (11.1%, n = 114) and “persistently low” (88.9%, n = 916). Levels of perinatal fatigue among women in the “persistently high” group were higher than those in the “persistently low” group across the six measurements. Complications, fatigue at T0, and employment status in late pregnancy were all significant predictors of trajectories. Additionally, the “persistently high” group had a greater prevalence of difficult baby care and weight retention and a lower prevalence of exclusive breastfeeding. Conclusions Our study proved the heterogeneity and characteristics of perinatal fatigue among women. Future research should concentrate on developing intervention packages targeted at specific individuals in order to alleviate perinatal fatigue in women.
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Xia, Haiou, Xiaoxiao Zhu, and Chunxiang Zhu. "Associations between pro-inflammatory cytokines and fatigue in pregnant women." PeerJ 10 (September 28, 2022): e13965. http://dx.doi.org/10.7717/peerj.13965.
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Background Fatigue is one of the most prevalent symptoms among pregnant women. In patients with various diseases, pro-inflammatory cytokines are associated with fatigue; however, such associations are unknown in pregnant women. Objectives The objective of this study was to examine the associations between pro-inflammatory cytokines and prenatal fatigue. Methods A cross-sectional study was conducted on 271 pregnant Chinese women in their third trimester of pregnancy. Patient-reported Outcome Measurement Information System (PROMIS) was used to evaluate women’s prenatal fatigue. Using enzyme-linked immunosorbent assay (ELISA), the serum concentrations of four pro-inflammatory cytokines, including tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), interleukin 6 (IL-6) and interleukin 8 (IL-8), were measured. The data was analyzed by correlation analysis and general linear regression analysis. Results In this sample, the mean (standard deviation) of fatigue scores was 51.94 (10.79). TNF-α (r = 0.21, p < 0.001), IL-6 (r = 0.134, p = 0.027) and IL-8 (r = 0.209, p = 0.001) were positively correlated to prenatal fatigue, although IL-1β was not. TNF-α (β = 0.263, p < 0.001), along with sleep quality (β = 0.27, p < 0.001) and depression (β = 0.376, p < 0.001) independently predicted prenatal fatigue. Conclusions TNF-α was identified as an independent biomarker for prenatal fatigue in our study. Reducing pro-inflammatory cytokines may be a unique method for lowering prenatal fatigue and, consequently, enhancing mother and child health.
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Russ, David W., and Jane A. Kent-Braun. "Sex differences in human skeletal muscle fatigue are eliminated under ischemic conditions." Journal of Applied Physiology 94, no. 6 (June 1, 2003): 2414–22. http://dx.doi.org/10.1152/japplphysiol.01145.2002.
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Several studies have suggested that women may be more resistant to muscle fatigue than men (Fulco CS, Rock PB, Muza SA, Lammi E, Cymerman A, Butterfield G, Moore, LG, Braun B, and Lewis SF. Acta Physiol Scand 167: 233–239, 1999) possibly because of differences in muscle oxidative metabolism. We evaluated muscle fatigue produced by intermittent, maximal volitional isometric contractions of the dorsiflexor muscles of healthy young (21–34 yr) men ( n = 8) and women ( n = 8) under two conditions: free-flow (FF) circulation and ischemia. Measures of voluntary and stimulated (10- and 50-Hz) force, central activation ratio (CAR), and compound muscle action potential (CMAP) were collected in each session. The ischemic protocol induced greater fatigue than the FF protocol, in both sexes, and was associated with greater reductions in CAR, CMAP, stimulated force, and the ratio of 10- to 50-Hz force compared with the FF condition. Women fatigued less than men in FF but not during ischemia, and this difference was roughly paralleled by a difference in CAR. No sex effects on the CMAP, tetanic force, and measures of excitation-contraction coupling function were found in the FF condition, suggesting that the primary mechanism behind the difference in fatigue was a relatively greater impairment of central activation in men. The observation that ischemia eliminated the sex differences in fatigue is consistent with a number of studies (Kent-Braun JA, Ng AV, Doyle JW, and Towse TF. J Appl Physiol93: 1813–1823, 2002) relating fatigue to muscle metabolism and might be the result of sex-based differences in metabolic pathway utilization during muscle contraction.
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Chiu, Hsiao-Hui, Lee-Ing Tsao, and Mei-Hsiang Lin. "Suffering Exhausted Life Like Burning at Both Ends of a Candle - Women With Menopausal Fatigue." International Journal of Studies in Nursing 5, no. 1 (March 30, 2020): 95. http://dx.doi.org/10.20849/ijsn.v5i1.722.
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Background: Fatigue is a common complaints for perimenopausal or menopausal women. It is a subjective feeling and deeply affect women's lives. Studies evaluating it as a marker for diseases or the transition of menopause among menopausal women are lacking.Aims: To explore the life experiences among women with menopausal fatigue.Methods: In- depth interview were conducted with 17 Taiwanese women with a mean age of 52.2years, who perceived themselves as getting tired or exhausted life but have no major or serious diseases were invited by in-depth interviewed. Data were analyzed by constant comparative method.Results: “Suffering exhausted life like burning at both ends of a candle” was the core category for describing and guiding the process of women with menopausal fatigue. During this process, “Energy Exhaustion” was identified as the antecedent condition. Once the woman became aware, she would begin the process of “Suffering exhausted life like burning at both ends of a candle”. This process would be marked by action and interaction among the categories of “Need refreshing or diverting attention”, “Seeking family or significance others help and supports”, and “Arranging leisure activities and exercise”. Throughout this process women viewed their fatigue life by acceptance by “Slowing and modifying my life paces” or retrieval it but felt frustration and recycling the process of Energy Exhaustion.Conclusion: Menopausal fatigue was viewed as suffering exhausted life like burning at both ends of a candle instead of a silent life message. It is like menopausal symptoms needing to attention.
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LEE, KATHRYN A. "Sleep and Fatigue." Annual Review of Nursing Research 19, no. 1 (January 2001): 249–73. http://dx.doi.org/10.1891/0739-6686.19.1.249.
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This chapter provides a review and synthesis of research on women’s sleep and fatigue from a nursing perspective. Most of the research involves four primary issues for women: menstrual cycles, childbearing, chronic mental or physical illness, and oncology. Research with healthy women focused on diurnal fluctuations in fatigue and relationships to sleep, without regard for exercise or level of daytime activity. Research on chronic illness and cancer fatigue focused on general fatigue and its impact on activity, without regard for sleep or therapeutic use of rest and naps. A comparison of these two areas highlights gaps in nursing knowledge about sleep and fatigue. Further research is needed to understand relationships between nonrestorative sleep, fatigue, and symptoms related to poor quality of life. From a synthesis of these studies, nonpharmacologic interventions that could be prove useful in promoting a higher quality of life for those with either acute or chronic fatigue are then proposed.
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Oliveira, Ana Maria da Silva Sousa, Mariana Azevedo Carvalho, Luis Nacul, Fábio Roberto Cabar, Amanda Wictky Fabri, Stela Verzinhasse Peres, Tatiana Assuncao Zaccara, et al. "Post-Viral Fatigue Following SARS-CoV-2 Infection during Pregnancy: A Longitudinal Comparative Study." International Journal of Environmental Research and Public Health 19, no. 23 (November 26, 2022): 15735. http://dx.doi.org/10.3390/ijerph192315735.
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Studies reported post-COVID-19 fatigue in the general population, but not among pregnant women. Our objectives were to determine prevalence, duration, and risk factors of post-viral fatigue among pregnant women with SARS-CoV-2. This study involved 588 pregnant women with SARS-CoV-2 during pregnancy or delivery in Brazil. Three groups were investigated: G1 (n = 259, symptomatic infection during pregnancy); G2 (n = 131, positive serology at delivery); G3 (n = 198, negative serology at delivery). We applied questionnaires investigating fatigue at determined timepoints after infection for G1, and after delivery for all groups; fatigue prevalence was then determined. Cox regression was used to estimate hazard ratio (HR) and 95% CI of the risk of remaining with fatigue in G1. Overall fatigue prevalence in G1 at six weeks, three months and six months were 40.6%, 33.6%, and 27.8%, respectively. Cumulative risk of remaining with fatigue increased over time, with HR of 1.69 (95% CI: 0.89–3.20) and 2.43 (95% CI: 1.49–3.95) for women with moderate and severe symptoms, respectively. Multivariate analysis showed cough and myalgia as independent risk factors in G1. Fatigue prevalence was significantly higher in G1 compared to G2 and G3. Post-viral fatigue prevalence is higher in women infected during pregnancy; fatigue’s risk and duration increased with the severity of infection.
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Cheng, Arthur, David S. Ditor, and Audrey L. Hicks. "A comparison of adductor pollicis fatigue in older men and women." Canadian Journal of Physiology and Pharmacology 81, no. 9 (September 1, 2003): 873–79. http://dx.doi.org/10.1139/y03-084.
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Sex differences in fatigue resistance of the adductor pollicis (AP) muscle were studied in 24 older adults who were divided into three groups: 12 older men (69.8 ± 4.60 years), 6 older women not on hormone replacement therapy (HRT) (70.2 ± 4.02 years), and 6 older women on HRT (68.7 ± 6.47 years). Fatigue in the AP muscle was induced using an intermittent (5 s contraction, 5 s rest) submaximal voluntary contraction (50% of maximal voluntary contraction (MVC)) protocol, which was continued until exhaustion (i.e., when subjects could either no longer maintain a 5-s contraction at 50% MVC or when the MVC was deemed to be lower than the target force). There was no effect of HRT on MVC or time to fatigue (TTF); therefore, the older women were pooled as one subject group. At baseline, men were stronger than women for MVC (75.9 ± 18.8 N in men vs. 56.8 ± 10.0 N in women; P < 0.05) and evoked twitch force (7.3 ± 1.7 N in men vs. 5.2 ± 0.8 N in women; P < 0.05). There was no difference in TTF between men and women (14.77 ± 7.06 min in men vs. 11.53 ± 4.91 min in women; P > 0.20), nor was there a significant relationship between baseline muscle force and TTF (r = 0.14). There was also no difference in the pattern of fatigue and recovery between the men and women. These results suggest that there is no difference in endurance or fatigue characteristics of the AP muscle in men and women over the age of 65 years, and that baseline muscle force does not predict fatigue resistance in this muscle.Key words: muscle fatigue, aging, gender differences.
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Almurdi, Muneera, and Syamala Buragadda. "Association Between Physical Activity and Post menopausal Symptoms in Saudi Women: A Cross-sectional Study." Iranian Rehabilitation Journal 19, no. 2 (June 1, 2021): 157–64. http://dx.doi.org/10.32598/irj.19.2.1237.1.
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Objectives: Menopause is the termination of a woman’s menstrual cycle for a year. In this condition, women’s health status declines due to hormonal changes and aging. Physical Activity (PA) is among the best available alternatives for managing menopause-related symptoms without any adverse effects. This study aimed to assess the relationship between PA and symptoms, such as fatigue, depression, and insomnia in Saudi menopausal women. Methods: This cross-sectional study involved 60 menopausal women; they were divided into physically active and inactive groups. The group allocation was conducted based on their PA level determined by the International Physical Activity Questionnaire Short-Form (IPAQ-SF). Menopausal symptoms, such as fatigue, depression, and insomnia were assessed using the Fatigue Severity Scale (FSS), Beck Depression Inventory-II (BDI-II), and Insomnia Severity Index (ISI), respectively, in the study groups. The association between PA and fatigue, depression, and insomnia was assessed using the Pearson correlation coefficient. The significance level was set at P≤0.05. Results: Fatigue, depression, and insomnia were more prevalent in physically inactive post-menopause women than the active women. A significant difference was observed in the outcome variables between the study groups. Furthermore, a significant association was detected between PA and fatigue, depression, and insomnia in the study participants. Discussion: Half of the explored menopausal women were physically active. Physically active menopausal women presented less fatigue, depression, and insomnia, compared to their inactive counterparts. This study suggested that PA positively impacted menopausal symptoms (fatigue, insomnia, & depression). Besides, the collected results highlighted the importance of physical activity among menopausal women.
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Bitner, Anna, Paweł Zalewski, Jacek Klawe, Mariusz Kozakiewicz, and Julia Newton. "Chronic fatigue syndrome in 57-year-old woman." Open Medicine 9, no. 1 (February 1, 2014): 126–32. http://dx.doi.org/10.2478/s11536-013-0243-9.
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AbstractChronic fatigue syndrome (CFS) is characterized by unexplained fatigue lasting for more than 6 months and accompanied by flulike symptoms. It most commonly affects women aged between 30 and 60 years. To date, clear diagnostic criteria allowing for unambiguous diagno-sis of CFS have not been established. We present a case of a 57-year-old woman with chronic fatigue syndrome in order to showcase the symptoms of this condition and propose a diagnos-tic protocol.
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Aldhahi, Monira I., Mohammed M. Alshehri, Faleh Alqahtani, and Abdulfattah Saeed Alqahtani. "A pilot study of the moderating effect of gender on the physical activity and fatigue severity among recovered COVID-19 patients." PLOS ONE 17, no. 7 (July 13, 2022): e0269954. http://dx.doi.org/10.1371/journal.pone.0269954.
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Background Clinical data point toward gender-based differences in COVID-19 severity. However, there is insufficient research examining whether gender predicts physical activity (PA) and fatigue severity in patients recovering from COVID-19. Therefore, this study aimed to characterize the PA and fatigue severity in a cohort of patients recovering from COVID-19 infection and measure the extent to which gender-based differences moderate the relationship of PA with fatigue. Method A cross-sectional survey was conducted in Riyadh, Saudi Arabia. The sample comprised patients recovering from COVID-19 over at least 3 months. Recovered patients were stratified into two groups based on gender. The survey included items pertaining to sociodemographic, a fatigue severity scale and a self-reported international PA questionnaire. Results Eighty-seven patients (44 women and 43 men) met the inclusion criteria. Compared with men, women reported sedentary behavior (70%) and high fatigue severity (64%). A significantly higher number of women had a low PA score compared with men (p = .002). The findings indicated that gender significantly moderates the effect of total PA in metabolic equivalents (METs; min/wk) on fatigue severity [F = 4.8, p = .03, ΔR2 = 0.24]. Conclusions The current study suggests that women might be at risk of higher fatigue severity, in addition to engaging less in PA. Physical activity may plays a significant role in modulate the fatigue severity. Consequently, interventions aimed at promoting physical activity in women stand high chances of addressing the disparity in the distribution of prevalence of fatigue between men and women.
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Fritschi, Cynthia, Chang Park, Laurie Quinn, and Eileen G. Collins. "Real-Time Associations Between Glucose Levels and Fatigue in Type 2 Diabetes: Sex and Time Effects." Biological Research For Nursing 22, no. 2 (February 3, 2020): 197–204. http://dx.doi.org/10.1177/1099800419898002.
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Objective: Fatigue is a pervasive and serious complaint among aging adults with type 2 diabetes. Anecdotally, hyperglycemia was thought to cause fatigue, but prior cross-sectional analyses failed to find any relationship between glucose levels and fatigue. However, study methodology may have caused this relationship to be missed. Our aim was to use concurrent and continuous data across 5 days to examine real-time momentary relationships between glucose and fatigue levels by week, day, and time of day. Additionally, we explored how these relationships differed by sex. Method: Participants ( N = 54, 51% male, 54% non-White) wore continuous glucose monitors and wrist actigraphy into which they inputted fatigue ratings 6–8 times daily during waking hours across 5 days. Generalized estimation equation models were used to explore the relationship between glucose and fatigue when averaged by week, day, and time of day. Differences by sex were also explored. Results: HbA1c and baseline and real-time fatigue were higher in women than in men. Baseline HbA1c and self-reported general fatigue were unrelated. Fatigue levels averaged by day and time of day were higher in women than in men ( p < .05). Glucose and fatigue were significantly related at all levels of data (weekly, daily, and time of day) in women but not men. Conclusions: Our findings suggest that, when measured concurrently, glucose excursions may affect fatigue levels in women.
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Soriano, Maria, Alejandro Alvarez-Bustos, Javier Ramos, Carmen Piquin, Pablo Osorio, Javier Ros, Miguel Ramírez, et al. "Cancer-related fatigue in cancer survivors (CS) with no active treatment." Journal of Clinical Oncology 35, no. 31_suppl (November 1, 2017): 238. http://dx.doi.org/10.1200/jco.2017.35.31_suppl.238.
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238 Background: Fatigue is a subjective experience that should be systematically assessed at the initial visit, at regular intervals and as clinically indicated. Quality of fatigue management should be included in institutional continuous quality improvement projects. The PERFORM questionnaire (PQ) was developed among Spanish speaking patients for the assessment of fatigue. Methods: Outpatients recruited for projects in which physical condition and physical activity (PA) were evaluated, rated their fatigue severity on the PQ (12-60, being 60 no fatigue). PHUEM-01 evaluated early colon CS after finishing adjuvant treatment (AT). PHUEM-02 early breast CS at the end of AT. PH-UEM-03 evaluated colorectal CS (localized and metastatic) at the time of diagnosis. MS-04 evaluated fatigue at the time of diagnosis of different tumors (localized and metastatic). Physical condition was evaluated through the one-mile walk test (VO2MAX) and handgrip dynamometer. Heart rate was measured as a sign of autonomic dysfunction. PA was objectively evaluated through accelerometers generating weekly MVPA information. Results: 262 CS (63% women) were recruited, (110 breast, 119 colorectal, 14 other), mean age 60. 30% of survivors reported no fatigue. Mean PERFORM score 48,34; VO2max 25.5 ml/kg/min; handgrip 29,14 kg; HR 75 bpm. Women, younger CS, CS with worse physical condition, higher BMI, higher HR and less active CS reported more fatigue (only sex, handgrip strength and weekly PA were statistically significant for the overall population). Breast CS reported higher scores of fatigue than colorectal CS (p < 0.000). For breast CS there was an association between fatigue and HR which was not seen in the overall population. Metastatic colorectal did not report worse scores of fatigue than CS with localized tumors. Conclusions: As a subjective symptom, fatigue is unpredictable and its severity and interference with daily activities can be bothersome in an unexpected population (young CS, early stages) with no active treatment. More physically active and fitter CS are less fatigued. Mechanisms underlying cancer-related fatigue could be different for different tumors. More research in prevalence, evaluation, mechanisms and management of fatigue is needed.
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Michelsen, Trond M., Anne Dørum, Claes G. Tropé, Sophie D. Fosså, and Alv A. Dahl. "Fatigue and Quality of Life After Risk-Reducing Salpingo-Oophorectomy in Women at Increased Risk for Hereditary Breast-Ovarian Cancer." International Journal of Gynecologic Cancer 19, no. 6 (July 2009): 1029–36. http://dx.doi.org/10.1111/igc.0b013e3181a83cd5.
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Background:Risk-reducing salpingo-oophorectomy (RRSO) is the safest intervention for prevention of ovarian cancer in women at increased risk for hereditary breast-ovarian cancer. Little is known about other effects of RRSO. The objective of this study was to investigate quality of life (QoL) and fatigue in a sample of women who had RRSO for increased cancer risk and to compare the findings with those of age-matched controls from the general population (NORM).Materials and Methods:In a cross-sectional follow-up mailed questionnaire design, 301 (67%) of 450 invited Norwegian women with RRSO attended. The questionnaire contained measures of QoL, fatigue, anxiety/depression, and body image, and questions about demography, lifestyle, and morbidity. The findings were compared with those of the NORM.Results:For RRSO women, mean age at survey was 53.7 years (SD, 9.2), mean age at RRSO was 48.4 years (SD 8.4), and median follow-up time was 5.0 years (range, 1-15 years). No clinically significant differences were observed between RRSO and NORM for any of the QoL or fatigue dimensions. In subgroup analyses of the RRSO group, no clinically significant differences in QoL and fatigue were observed between those who had surgery before or after age 50 years, or between BRCA1/2 carriers and women with unknown mutation statuses. Women who had cancer (32%), however, showed clinically significant lower levels of QoL and more fatigue than women without cancer.Conclusions:Women who had RRSO showed similar levels of QoL and fatigue as NORM. Women who had cancer before RRSO had lower levels of QoL and more fatigue.
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Andarini, Yulia Dwi, and Tofan Agung Eka Prasetya. "The Correlation of Occupational Stress With Subjective Fatigue Women Workers In Weaving Loom Unit PT. X." Journal Of Vocational Health Studies 1, no. 1 (July 3, 2017): 18. http://dx.doi.org/10.20473/jvhs.v1.i1.2017.18-22.
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Background : An occupation with a high risk of work fatigue is an occupation in textile industry. The involvement of women in the textile industry sector in Indonesia is dominant. Women labors who run work on domestic and public sector will be less inclined a work fatigue. Subjective fatigue is the problem faced by women workers at production division weaving loom unit of PT. X. Purpose : This study aimed to determine occupational stress correlation with subjective fatigue in weaving loom unit PT. X. Methods : Type of this observational analytic study was using a cross sectional design. The number of research subject were 95 people. An occupational stress is independent variable. The dependent variable is a subjective fatigue. Occupational stress measurement was using job stress indicator questionnaire. Subjective fatigue measurement was using Subjective Self Rating Test questionnaires. Chi square test used as significance test. All test used 95% confidence interval and significance level of p=0,05. Result : Chi square test result showed that occupational stress has significant association with subjective fatigue. Conclusion : An occupational stress has a positive correlation with subjective fatigue women workers in weaving loom unit PT. X.
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Estévez-López, Fernando, Diego F. Salazar-Tortosa, Daniel Camiletti-Moirón, Blanca Gavilán-Carrera, Virginia A. Aparicio, Pedro Acosta-Manzano, Víctor Segura-Jiménez, et al. "Fatigue in Women with Fibromyalgia: A Gene-Physical Activity Interaction Study." Journal of Clinical Medicine 10, no. 9 (April 28, 2021): 1902. http://dx.doi.org/10.3390/jcm10091902.
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Fatigue is a cardinal symptom in fibromyalgia. Fatigue is assumed to be the result of genetic susceptibility and environmental factors. We aimed at examining the role of genetic susceptibility for fatigue in southern Spanish women with fibromyalgia, by looking at single nucleotide polymorphisms in 34 fibromyalgia candidate-genes, at the interactions between genes, and at the gene-physical activity interactions. We extracted DNA from saliva of 276 fibromyalgia women to analyze gene-polymorphisms. Accelerometers registered physical activity and sedentary behavior. Fatigue was assessed with the Multidimensional Fatigue Inventory. Based on the Bonferroni’s and False Discovery Rate values, we found that the genotype of the rs4453709 polymorphism (sodium channel protein type 9 subunit alpha, SCN9A, gene) was related to reduced motivation (AT carriers showed the highest reduced motivation) and reduced activity (AA carriers showed the lowest reduced activity). Carriers of the heterozygous genotype of the rs1801133 (methylene tetrahydrofolate reductase, MTHFR, gene) or rs4597545 (SCN9A gene) polymorphisms who were physically active reported lower scores on fatigue compared to their inactive counterparts. Highly sedentary carriers of the homozygous genotype of the rs7607967 polymorphism (AA/GG genotype; SCN9A gene) presented more reduced activity (a dimension of fatigue) than those with lower levels of sedentary behavior. Collectively, findings from the present study suggest that the contribution of genetics and gene-physical activity interaction to fatigue in fibromyalgia is modest.
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Schjolberg, Tore Kr, Marylin Dodd, Nils Henriksen, and Tone Rustoen. "Factors affecting hope in a sample of fatigued breast cancer outpatients." Palliative and Supportive Care 9, no. 1 (February 25, 2011): 63–72. http://dx.doi.org/10.1017/s1478951510000556.
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AbstractObjective:The aims of this study of women with breast cancer were: to describe the levels of hope and compare hope scores for these patients with a sample from the general Norwegian population; to describe the relationship between hope and fatigue; and finally to evaluate the effect of demographic and clinical characteristics and fatigue on hope.Method:A total of 160 Norwegian outpatients with cancer and fatigue (>2.5 on a 0–10 scale) completed the Herth Hope Index (HHI), Fatigue Questionnaire (FQ), and Self-administered Comorbidity Questionnaire (SCQ).Results:The mean age of the women was 55.3 years (SD = 9.4), 81% lived with someone, and 67% were employed. The most common comorbidities were back pain (42%), osteoarthritis (26%), and headache (19%). The fatigued breast cancer patients reported significantly higher total hope scores than the general Norwegian population (p < .0001). The difference was largest in the individual item “I can see a light in the tunnel,” to which the cancer sample reported the highest scores, but they also felt more “scared about the future.” Total hope score was negatively correlated with total fatigue (TF), mental fatigue (MF), and chronic fatigue (CF), but not with physical fatigue (PF). Demographic and clinical characteristics were not significantly related to hope, except that patients who were married or living with someone showed significantly higher total hope scores.Significance of results:The higher levels of hope in breast cancer patients compared with the general Norwegian population may reflect a response shift in patients after getting a cancer diagnosis. The fact that a significant relationship was found between total hope scores and living arrangements may indicate that hope is easier to establish when patients have someone to relate to or receive support from. Hope and total fatigue were significantly, but weakly correlated.
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Kwakkenbos, Linda, Ollie Minton, Patrick C. Stone, Susanna Alexander, Murray Baron, Marie Hudson, and Brett D. Thombs. "Can the Cancer-related Fatigue Case-definition Criteria Be Applied to Chronic Medical Illness? A Comparison between Breast Cancer and Systemic Sclerosis." Journal of Rheumatology 42, no. 7 (June 1, 2015): 1156–62. http://dx.doi.org/10.3899/jrheum.141421.
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Objective.Fatigue is a crucial determinant of quality of life across rheumatic diseases, but the lack of agreed-upon standards for identifying clinically significant fatigue hinders research and clinical management. Case definition criteria for cancer-related fatigue were proposed for inclusion in the International Classification of Diseases. The objective was to evaluate whether the cancer-related fatigue case definition performed equivalently in women with breast cancer and systemic sclerosis (SSc) and could be used to identify patients with chronic illness-related fatigue.Methods.The cancer-related fatigue interview (case definition criteria met if ≥ 5 of 9 fatigue-related symptoms present with functional impairment) was completed by 291 women with SSc and 278 women successfully treated for breast cancer. Differential item functioning was assessed with the multiple indicator multiple cause model.Results.Items 3 (concentration) and 10 (short-term memory) were endorsed significantly less often by women with SSc compared with cancer, controlling for responses on other items. Omitting these 2 items from the case definition and requiring 4 out of the 7 remaining symptoms resulted in a similar overall prevalence of cancer-related fatigue in the cancer sample compared with the original criteria (37.4% vs 37.8%, respectively), with 97.5% of patients diagnosed identically with both definitions. Prevalence of chronic illness-related fatigue was 36.1% in SSc using 4 of 7 symptoms.Conclusion.The cancer-related fatigue criteria can be used equivalently to identify patients with chronic illness-related fatigue when 2 cognitive fatigue symptoms are omitted. Harmonized definitions and measurement of clinically significant fatigue will advance research and clinical management of fatigue in rheumatic diseases and other conditions.
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Skarpsno, Eivind Schjelderup, Tom Ivar Lund Nilsen, Trond Sand, Knut Hagen, and Paul Jarle Mork. "Physical work exposure, chronic musculoskeletal pain and risk of insomnia: longitudinal data from the HUNT study, Norway." Occupational and Environmental Medicine 75, no. 6 (April 19, 2018): 421–26. http://dx.doi.org/10.1136/oemed-2018-105050.
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ObjectivesTo prospectively investigate (i) the association of physical work demands and work-related physical fatigue with risk of insomnia symptoms and (ii) if these associations are influenced by chronic musculoskeletal pain.MethodsProspective study on a working population of 8563 women and 7598 men participating in the Nord-Trøndelag Health Study (Norway) who reported no insomnia at baseline in 1995–1997. Occurrence of insomnia symptoms was assessed at follow-up in 2006–2008. A Poisson regression model was used to calculate adjusted risk ratios (RRs) for insomnia symptoms with 95% CI.ResultsCompared with workers without work-related physical fatigue, women and men who reported that they were always fatigued had RRs of insomnia of 2.34 (95% CI 1.72 to 3.18) and 2.47 (95% CI 1.59 to 3.83), respectively. Overall, physical work demands was not associated with risk of insomnia, although men who reported heavy physical work had an RR of 0.67 (95% CI 0.47 to 0.97) compared with men with mostly sedentary work. Compared with the reference group of workers without work-related physical fatigue and no chronic pain, analyses of joint effects showed that women with excessive work-related fatigue had an RR of 4.20 (95% CI 2.95 to 5.98) if they reported chronic pain and an RR of 1.67 (95% CI 0.87 to 3.18) if they did not. Corresponding RRs in men were 3.55 (95% CI 2.11 to 5.98) and 2.13 (95% CI 1.07 to 4.25).ConclusionThese findings suggest that there is an interplay between work-related physical fatigue and musculoskeletal pain that should receive particular attention in the prevention of insomnia in working populations.
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Rudroff, Thorsten, Craig D. Workman, and Andrew D. Bryant. "Potential Factors That Contribute to Post-COVID-19 Fatigue in Women." Brain Sciences 12, no. 5 (April 26, 2022): 556. http://dx.doi.org/10.3390/brainsci12050556.
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Mortality of acute coronavirus disease (COVID-19) is higher in men than in women. On the contrary, women experience more long-term consequences of the disease, such as fatigue. In this perspective article, we proposed a model of the potential factors that might contribute to the higher incidence of post-COVID-19 fatigue in women. Specifically, psycho-physiological factors are features that might increase central factors (e.g., inflammation) and result in greater perceptions of fatigue. Furthermore, pre-existing conditions likely play a prominent role. This model offers a framework for researchers and clinicians, and future research is required to validate our proposed model and elucidate all mechanisms of the increased incidence and prevalence of post-COVID-19 fatigue in women.
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Mundo-López, Antonio, Olga Ocón-Hernández, Ainhoa P. San-Sebastián, Noelia Galiano-Castillo, Olga Rodríguez-Pérez, María S. Arroyo-Luque, Manuel Arroyo-Morales, Irene Cantarero-Villanueva, Carolina Fernández-Lao, and Francisco Artacho-Cordón. "Contribution of Chronic Fatigue to Psychosocial Status and Quality of Life in Spanish Women Diagnosed with Endometriosis." International Journal of Environmental Research and Public Health 17, no. 11 (May 28, 2020): 3831. http://dx.doi.org/10.3390/ijerph17113831.
Full textAbstract:
Aim: To analyze the levels of chronic fatigue in Spanish women with endometriosis and its relationship with their psychosocial status and quality of life (QoL). Methods: A total of 230 Spanish women with a clinical diagnosis of endometriosis were recruited. Chronic fatigue (Piper Fatigue Scale) and pelvic pain (Numeric Rating Scale) were evaluated. An on-line battery of validated scales was used to assess psychosocial status [Hospital Anxiety and Depression Scale, Scale for Mood Assessment, Pain Catastrophizing Scale, Pittsburgh Sleep Quality Index, Gastrointestinal Quality of Life Index, Female Sexual Function Index and Medical Outcomes Study-Social Support Survey] and QoL [Endometriosis-Health Profile questionnaire-30]. Associations between fatigue and both psychosocial and QoL outcomes were explored through multivariate regression models. Results: One-third and one-half of women showed moderate and severe fatigue, respectively. Fatigue was associated with higher anxiety and depression, poorer sleep quality, poorer sexual functioning, worse gastrointestinal health, higher catastrophizing thoughts, higher anger/hostility scores and lower QoL (p-values < 0.050). Moreover, fatigue and catastrophizing thoughts showed a mediating effect on the association between pelvic pain and QoL. Conclusion: This work reveals the important role of fatigue in the association between pain, psychosocial status, and QoL of Spanish women with endometriosis.
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Alvarez, Marcos C., Maria Luiza L. Albuquerque, Henrique P. Neiva, Luis Cid, Filipe Rodrigues, Diogo S. Teixeira, and Diogo Monteiro. "Differences between Portuguese and Brazilian Patients with Fibromyalgia Syndrome: Exploring the Associations across Age, Time of Diagnosis, and Fatigue-Related Symptoms." Medicina 57, no. 4 (April 1, 2021): 322. http://dx.doi.org/10.3390/medicina57040322.
Full textAbstract:
Background and Objectives: The current literature demonstrates that different cultures have different perceptions of the symptoms of Fibromyalgia Syndrome (FM). The aim of the study was to explore the differences between Brazilian and Portuguese patients with FM in their fatigue experience and to measure the differences in the perception of fatigue according to age and duration of diagnosis. Materials and Methods: In total, 209 Portuguese women aged between 21 and 75 years old (M = 47.44; SD = 10.73) and 429 Brazilian women aged between 18 and 77 years old (M = 46.51; SD = 9.24) were recruited to participate in the present study. Participants filled out the items in the Multidimensional Daily Fatigue-Fibromyalgia-17 Diary (MDF-Fibro-17), a specific tool to measure the level of five components of FM-related fatigue. Results: The results showed a greater perception of all of the components of fatigue in the Brazilian sample. No significant differences were found related to the age and duration of FM diagnosis. Conclusions: Overall, there are significant differences in fatigue symptoms between Portuguese and Brazilian women with FM, suggesting that cultural and geographical differences should be considered when describing fatigue-related symptoms in women with FM.