Dissertations / Theses on the topic 'Family – Senegal'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 17 dissertations / theses for your research on the topic 'Family – Senegal.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.
Villar, Paola. "Essays in Family Economics in Senegal." Thesis, Paris Sciences et Lettres (ComUE), 2018. http://www.theses.fr/2018PSLEH131.
Full textIn the West Africa subregion, poverty is pervasive and social protection at the state-level, as well as formal financial markets poorly function. In such a context, families fulfill important roles, which shape the economic and social life of its members and are key drivers of economic development. How this private institution performs is, however, quite a debate and a growing body of the literature in development economics has focused on the question of the economic inefficiencies of the family institution. My PhD thesis builds upon this literature and contributes to it by shedding light on how individual economic decisions are taken within the family in Senegal, and in which cases the family fails to ensure individual welfare of its members.The first chapter focuses on the individual costs of the informal redistribution that take place within and between social networks, and in particular within the extended family. Using a lab-in the field experiment, we aim at identifying the hidden costs of social obligations for redistribution on individual resource allocation choices. Our results are threefold: (i) we estimate a social tax of about 9\%; (ii) we provide evidence on strong distortions in individual allocation choices; (iii) our results point at people fearing redistributive pressure from the extended family members, but not from within the household or from friends and neighbors. We expand on prior literature by both identifying the individual cost of informal redistribution and then relating it to postexperiment resource-allocation decisions, and by disentangling intra- and interhousehold redistributive pressure. The second chapter investigates how the health environment prevents parents from investing in child health. Its main objective is to investigate whether the health risks faced by children, and in particular their competing nature as mortality risks, depress parental investment in child health. We argue that there are complementarities between disease-specific investments and we test this hypothesis by exploiting recent interventions that made anti-malaria products suddenly affordable to most households in 2009 in Senegal. Our first contribution is to be the first to use data on private health expenditures to validate a model with complementarities between disease-specific investments. Our second contribution is to show that parental behavioral responses clearly complement anti-malaria campaigns, whereby they magnify their impact on all-cause mortality for children. Finally, the third chapter explores how a quite harmful ex-post risk management strategy, child marriage, relates to changes in family structures (mortality shocks). In particular, I investigate whether paternal death induces adverse marriage outcomes for young orphans. I also discuss the channel that could induce such effects. My results underpinned the high vulnerability of this group of children: when the father dies, the young girls are more likely to marry as child brides and to be child mothers than their non-orphan counterparts. Those girls have more frequently broken marital trajectories, in particular due to divorce. This paper builds upon the existing demographic literature and provides at least two contributions. First, it is, to my knowledge, the first to study jointly the timing of the father's death and other dimensions of well-being such as fertility, marital dissolution and consumption. Second, it discusses the extent to which selection on unobservables might bias the analysis, an issue that is discarded in most studies
Boltz, Marie. "Informal Redistribution and Savings in the Extended Family in Senegal." Paris, EHESS, 2015. http://www.theses.fr/2015EHES0128.
Full textThis PhD dissertation aims at analyzing the effect of informal redistribution, taking mostly place within the extended family, on individuals' resource allocation choices in Sub-Saharan Africa. Indeed, in this region, due to limited access to markets for insurance, credit and savings, and to formal redistribution, individuals are vulnerable to life risks and economic shocks. To protect themselves against these risks, individuals rely mainly on two strategies: informal redistribution and informal savings. I analyze in this thesis how informal redistribution within the extended family affects individual savings decisions. The first chapter is based on an original qualitative survey conducted in Senegal in 2012 and propose a detailed analysis of the relationship between the transfer senders and the recipients within several family networks to understand the dynamics of resource sharing in the extended family and the social norms attached to these transfers. In the second Chapter, I investigate transfer patterns within a sibship and analyze how these patterns are related to saving decisions, using the nationally-representative ' Pauvrete et Structure Familiale' (PSF) suvey in Senegal. I find some evidence of high redistributive obligations that come generally at the cost of lower savings achieved for the main transfer senders. Based on an original lab experiment, in the third chapter, I highlight the widespread use of costly strategies aimed at circumventing these redistributive norms, namely income hiding. I identify the distortionary effects of such strategies on resource allocation decisions. In particular, I elicit a high willingness-to-pay to hide income from peers in the lab and show that hidden income induce a lower share of the gains devoted to transfers out of the lab, compensated by an increase in personal expenses. Finally, in my last chapter, using the panel of individuals of the PSF survey, I show that monogamous wives, when facing a higher risk of becoming polygamous, invest in self-protective strategies by saving more and spending more on personal expenses and on the education of their children
Hann, Agnes C. E. "An ethnographic study of family, livelihoods and women's everyday lives in Dakar, Senegal." Thesis, London School of Economics and Political Science (University of London), 2013. http://etheses.lse.ac.uk/722/.
Full textLondon, Scott Barry 1962. "Family law, marital disputing and domestic violence in post-colonial Senegal, West Africa." Diss., The University of Arizona, 1999. http://hdl.handle.net/10150/284052.
Full textMoahi, Refilwe M. "Women's Advancement in Francophone West Africa: A Comparison of Mali and Senegal." Scholarship @ Claremont, 2013. http://scholarship.claremont.edu/scripps_theses/256.
Full textLangdji, Anne Ruedisili. "Factors that influence disclosure or non-disclosure of one's HIV-positive status to friends, family and regular sexual partners in Linguere, Senegal." Thesis, University of the Western Cape, 2012. http://hdl.handle.net/11394/4511.
Full textBackground: Disclosure in the context of HIV is the sharing of information about one’s HIV-positive status with someone else. In the case of people living with HIV (PLHIV), many factors influence their decision to disclose. As with other illnesses there is a concern about possible discrimination or stigma. On the other hand, disclosure can lead to higher levels of support and better management of HIV infection. Types of disclosure can also vary depending on the need of the PLHIV, being partial or full, in order to gain the most benefit. Self-disclosure or mediated disclosure with the assistance of someone else is controlled by the PLHIV, whereas involuntary or forced disclosure might not be under the PLHIV's control and thus more likely to have negative consequences. No studies have been done in the rural area of Linguère, Senegal or in the rest of the country to identify the factors that influence the decisions of PLHIV around disclosure. Senegal has a concentrated HIV epidemic with national HIV prevalence stable at 0.7% in 2005 and 2010 Demographic and Health Surveys. Linguère District's HIV prevalence was at 0.8% in 2003. By knowing more about what motivates PLHIV to disclose or not disclose their status, service providers and others can better support PLHIV to practise beneficial disclosure. Aim: The aim of this study was to explore factors that influence the decision to disclose or not disclose one's HIV-positive status to regular sexual partners, friends and family in Linguère District,Senegal. Methods: A qualitative method with in-depth interviews was used to explore the factors that influenced decisions concerning disclosure. Fifteen PLHIV were identified through purposive sampling based on criteria such as marital status, gender and prior disclosure decisions. In addition, four service providers from the AIDS service organization, Projet SSP, and the district health and social workers served as key informants. The interviews were recorded, transcribed and translated from the local languages into French. Record reviews of the HIV/AIDS service organization complemented the interviews. The fieldwork was conducted in the study setting for two weeks in January 2012. The data was analysed through thematic analysis. Findings: The main themes that emerged as reasons for disclosure were maintaining psychosocial well-being, existence of trusting relationships, need for support with health care, reciprocal obligations and concern for others, whereas reasons for non-disclosure included stigma and discrimination and negative impact on family. However, the factors varied from one participant to another and could not consistently be attributed to one group or another, whether man or woman, married or divorced,etc. Influencing factors were related to gaining support for the participant or avoiding problems. Concerns about stigma were great and included reference to wanting others to have soutoura— privacy, dignity, respect. There were also factors which took into consideration the consequence for the person to whom they might disclose, such as desire to avoid upset or desire to seek testing and possible care for a spouse. Of the participants who had disclosed, there were no cases of severe negative consequences. Not one participant expressed regret for having disclosed, rather they acknowledged that there were positive benefits for themselves and sometimes also the other person to whom disclosure was made. The roles of the service providers and the support group were also influential in decision-making around disclosure, with a good number of cases of mediated disclosure. Conclusion: In line with consequence theory, PLHIV weighed up their benefits and costs when decisions around disclosure were contemplated. The benefits were that PLHIV who chose to disclose gained from increased social support and better management of their HIV infection. At the same time further transmission of infection was potentially reduced and others were oriented for testing and for access to care if needed. In general, HIV continues to be a particularly stigmatising condition and thus the majority of PLHIV in this study judged that it is not worth the risk of possible abandonment,rejection or slander to disclose their status, regardless of the fact that few have actually experienced severe negative consequences as a result of actual disclosure. Because of support provided through service providers and the support group, however, those participants who had chosen to disclose to someone outside of the support group were reaping benefits and also likely avoiding the need to turn to risky activities, such as transactional sex or formal sex work. Recommendations: Recommendations drawn from this study include the need to support programmes or initiatives which seek to reduce HIV-related stigma. There is also the need for leaders in the community to show support for PLHIV which can reduce stigma. Health care and service providers should be aware of the needs of PLHIV and the changes that may arise over time which could lead to a decision to practise beneficial disclosure. They should also learn from the experiences shared by other PLHIV which can in turn be shared. They should receive further training in order to better understand the complexity of disclosure and to assist with mediated disclosure.
Niyonsaba, Emmanuel. "Vieillissements pluriels : Expériences des "parents" âgés Sénégalais en cours de fragilisation." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMLH27.
Full textThis thesis is part of an analysis of the contemporary dynamics of aging in African societies, particularly in Senegal. It proposes to explore the experiences of elderly "parents" in the process of becoming fragile through the prism of solidarity in a context of social change, to grasp the relative ambivalences, on the one hand in their place within the family and social sphere, and on the other hand in the representations of aging. This research deconstructs first of all the representation of aging by showing that the elderly parents are not the "simple assisted", but actors within the family solidarity and that "their ageing" are plural, dynamic and rich of inventiveness. Then, from the qualitative surveys carried out in Senegal and in a complementary way with Senegalese migrants living in France (Le Havre), the research highlights the limits of family solidarities in the social accompaniment of elderly "parents" and calls for imagining of varied solutions to ageing people. Finally, the transformations in the family modalities of exercising of solidarities towards the elderly invite to a reversal of glance, if not dominant paradigm, in the way of thinking old age. This thesis is a contribution to the knowledge of the multiple experiences of aging
N'Diaye, Marième. "La politique constitutive au Sud : refonder le droit de la famille au Sénégal et au Maroc." Thesis, Bordeaux 4, 2012. http://www.theses.fr/2012BOR40019/document.
Full textIn Muslim countries, Family Law is a highly sensitive matter, which generates recurrent controversy, mainly polarised around Islamic and feminist positions. This is, for instance, what can be observed in Senegal and Morocco. In both countries, the legislator tried to mediate this tension by strengthening Women’s Rights within a text that conciliates Islamic imperatives and injunction to modernity. But this solution is far from receiving unanimous support.Taking the Family Law debate as a starting point, this work combines public policy studies and political sociology of law to analyse how the State tries to regulate the intimate sphere in order to be viewed as the sole domination apparatus within a context of strong normative pluralism. The comparison between the Moroccan and the Senegalese States - a comparison based on ‘dramatic contrasts’- allows to focus the analysis on the differences between the Morocco and Senegalese states in terms of capacity and legitimacy, and thus helps us in better understanding the specificity of state-institutionalisation processes in developing countries.In both cases, the State tries to take advantage from the controversy. It plays on the different normative systems and involves all the actors who acknowledge it as the legitimate arbitrator in order to keep and consolidate its power of law framing. Furthermore, in order to overcome the difficulties linked to law enforcement, the State relies on non-state actors to apply the law. This evidences and confirms the fact that Family Law is the result of a process of co-production. Even if State jurisprudence does not constitute the only normative order, but one amongst others, it nevertheless importantly influences individual behaviour on both the cognitive and the experiential levels. It thus reinforces the State’s pretention to constitute the ultimate political authority
Franckel, Aurélien. "LES COMPORTEMENTS DE RECOURS AUX SOINS EN MILIEU RURAL AU SENEGAL. Le cas des enfants fébriles à Niakhar." Phd thesis, Université de Nanterre - Paris X, 2004. http://tel.archives-ouvertes.fr/tel-00195109.
Full textNdiaye, Macodou. "Les usages sociaux des groupes de travail au Sénégal : facteurs d'égalisation des chances à l'école." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM3094.
Full textWork groups are part of the main informal school life-stirring factors in Senegal. Though they are at the core of socializing activities in high school education, they have never been studied on a sociological basis. Nevertheless, one has to admit that in the past years, they have become simultaneous and alternative to official and regular transmission of education contents due to the ever growing incapacity of school to take on this essential mission of students’ supervision. Qualitative and quantitative surveys carried towards 110 work groups show that these groups are where gender-related practices start off. Two socializing models, introverted and extroverted, regulate social activities and school and professional projects. The model we shall call “introverted” lead girls, one the one hand, to a limited use of school sociability activities in order to favor their matrimonial project and short-term trainings. On the other hand, boys in this model are encouraged to build on a strong school and professional project. This thesis study questions the on-going transformations in the Senegalese socializing trends, that can be partly explained by the access of women to modern employment sectors. This feminine presence on the employment market doesn’t trigger necessarily a negotiation in parental terms. The study of the work groups’ role in school success show that disadvantaged social groups benefit a lot from socializing activities through access to a social space prone to school and professional vocations
Stanard, Pia. "AFRICAN AMERICAN CHILDREN LIVING IN URBAN ENVIRONMENTS: AN INVESTIGATION OF EARLY LITERACY AND THE INFLUENCE OF PSYCHOLOGICAL STRENGTHS AND FAMILY SUPPORT." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2257.
Full textRodríguez, García Dan. "Endogamia, exogamia y relaciones interétnicas. Un estudio sobre la formación y dinámica de la pareja y la familia centrado en inmigrantes de Senegal y Gambia entre Cataluña y África." Doctoral thesis, Universitat Autònoma de Barcelona, 2002. http://hdl.handle.net/10803/5754.
Full textLos objetivos generales planteados son: 1) conocer cómo afecta la migración en la formación de la pareja/familia, analizando qué factores intervienen en el proceso, y dedicando una atención particular a la formación de familias mixtas (bi-nacionales); 2) avanzar en una conceptualización multidisciplinar y transcultural del parentesco, y producir un conocimiento que sirva para comprender y afrontar los procesos de interculturalidad en las sociedades plurales a un nivel profundo.
Las conclusiones señalan que los patrones de elección matrimonial son uno de los aspectos que menos varía con la migración, y que la endogamia y la homogamia (o en todo caso hipergamia para los inmigrantes) son las tendencias que predominan. Esto ocurre en todos los niveles analizados; a saber: país/región de nacimiento-socialización; religión; grupo étnico; familia (vínculo de parentesco) y clase-estatus social. Las razones son tanto estructurales como normativas: por un lado, está el patrón migratorio masculino y el proyecto de migración temporal en el contexto de estrategias migratorias colectivas organizadas fundamentalmente por la familia, donde el matrimonio concertado tiene una función cohesionadora de la estructura de parentesco. Por otro lado, la endogamia supone un elemento de referencia dentro de la organización familiar, como soporte básico y principal vehículo para la transmisión de los valores de la sociedad de origen (aquí el Islam actúa como catalizador cultural). La mayor conectividad de la red comunitaria en origen y en destino conduce la endogamia; lo contrario compele a la exogamia. Sin embargo, no se trata de procesos irreversibles ni excluyentes. Se cumplen también tres hipótesis secundarias: a) Los hombres son más exógamos que las mujeres, tanto por factores socio-culturales (Islam, estructura patriarcal) como estructurales (migración masculina); b) La exogamia es mayor en las relaciones 'informales' que en las 'formales', además de porque a nivel público la presión de la norma es mayor, por procesos de xenofilia y mixofilia (occidentalidad-modernidad vs. extranjeridad-exostismo); y c) Las 'generaciones jóvenes' (i.e. los inmigrantes más jóvenes y los descendientes de inmigrantes) son más exógamas que las 'generaciones viejas', debido a la desvinculación con el país de origen propio o de los padres, y a la consecuente diversificación de las redes sociales y los procesos de secularización.
Las aportaciones de la investigación se pueden resumir en que: 1) cabe relativizar el papel del factor cultural en los procesos de endogamia/exogamia, en favor de los aspectos de clase social (la homogamia socio-económica predomina tanto en las uniones endógamas como en las exógamas); 2) tanto la consideración de la exogamia como panacea de la integración, como la consideración unilateralmente negativa de la endogamia (ghettización), deben ser cuestionadas (la endogamia suele responder a la articulación de una red social básica en la sociedad de acogida, y el mestizaje no es una precondición para la integración estructural); y 3) la formación de familias mixtas (bi-nacionales) en el marco de la transnacionalidad, obliga a replantearse los esquemas tradicionales sobre lo que constituye el lugar y la diferencia, lo que implica cambios sociopolíticos estructurales (e.g. en cuanto a la definición de ciudadanía).
This thesis research was carried out between 1994 and 2002, and entailed multi-sited fieldwork (Spain, United Kingdom, The Gambia). It incorporates both qualitative (ethnographic) and quantitative research methods. The thesis deals with one of the most important aspects of interethnic relations: partner choice, family formation and cultural adaptation -in the context of transnational migration- among immigrants in receiving countries. Processes of endogamy and exogamy (i.e. marriage and intimate informal relationships inside/outside one's category or group), a central aspect of the discussion, are explored through considering the case of African immigrants -especially Senegalese and Gambian immigrants- living in Catalonia, Spain.
The thesis has the following general objectives: 1) to understand better how migration affects the formation of the couple/family, an understanding which is arrived at through an analysis of the factors involved in partner choice, and a close examination of the formation and experiences of bi-national (i.e. Senegalese/Gambian-Spanish) families; 2) to contribute to an interdisciplinary and cross-cultural conceptualization of kinship; 3) to understand better interethnic relations and patterns of social and cultural adaptation in pluralistic societies.
The conclusions point out that patterns of partner choice are one of the most stable aspects of processes of migration, and that endogamy and homogamy (if not, hypergamy) are the predominant trends. These patterns are present at all the different levels analysed here, whether country or region of birth; religious affiliation; ethnic group; or family (consanguinity) and social class/status. The causes are both structural and normative. On the one hand, endogamy prevails due to the masculine migratory pattern and the plan of temporary migration (i.e. a plan ultimately to return to and invest in the society of departure), which should be seen in the context of collective migratory strategies, organised by the family of origin; in this context, arranged marriages function as an element of cohesion of the kinship structure. On the other hand, endogamy is a principal vehicle for the maintenance of cultural and social values and practices (Islam works here as a cultural catalyst). In other words, a greater connection with one's community network, both within the society of origin and the society of destination, leads to endogamy, while a lesser connection leads to exogamy. However, endogamy and exogamy are neither irreversible nor exclusive processes.
Three other secondary hypotheses are validated in this research: a) men are more exogamous than women because of both socio-cultural factors (Islam and the global patriarchal structure) and structural factors (masculine migratory patterns); b) exogamy has a higher incidence in 'informal' than 'formal' relationships due to public pressure and accepted norms surrounding marriage, as well as processes of xenophilia and mixophilia (i.e., Westernness-modernity vs. foreignness-exoticism); c) 'younger generations' (i.e. young immigrants and descendants of immigrants) are more exogamous than 'older generations', attributable to the former's detachment from their own, or their parents', country of origin, and to the consequent diversification of social networks and processes of secularization that occur.
The research contributions of this work can be summarized as follows: 1) greater importance should be awarded to factors of social class than culture when considering processes of endogamy/exogamy, given that socio-economic homogamy exists both among endogamous and exogamous couples; 2) it is a mistake to consider a priori endogamy as a negative or an anti-integratory practice (ghettoization), or exogamy as a panacea of integration: endogamy is linked to the necessity of articulating a basic social and kinship network in the receiving society, and exogamy (métissage) does not necessarily mean structural integration; and 3) the formation of bi-national families within the dynamic and fluid context of transnationalism challenges traditional ideas of location and difference, a reality that leads to socio-political changes at a structural level around the globe (i.e. a rearticulated definition of citizenship).
Faucilhon, Emmanuelle. "Cinéaste amateur dans les colonies : expérience, filiation et reconstruction cinématographique." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM3145.
Full textThe films corpus is made by amateur films shot by colonials in the French colonies, Madagascar and Senegal. This source corpus is enriched by contemporary films using these amateur films and films from the colonial era. As part of a practice of action research, two films were made. In 3 movements we tried to determine the value colonial home movies may have today. We relied on the pragmatic anthropology and ordinary philosophy to understand the issues of these films. The starting assumption was that these films had been abandoned, they had no more value as a result of a colonial state denied by settlers. Our historical and sociological surveys show that this lack of value is a denial of reality of the colonial situation, denying both injustice and emotional ties that had been created mainly between the settler children and servants. Hence the paradox of films called "domestic" is that domestics are absent. This lack is essential. Without nannies and boys, these films are a no man's land. Moreover, the colonial context creates a report view illegitimacy illegality of these films. In conclusion we propose firstly a cinematic reconstruction method that puts the heart of its system linked to the three actors amateur films: the filmmakers, the filmed people and those in the fields Out. Secondly we propose the creation of an institute of colonial amateur films based on principles established by an ethic of audiovisual archiving that allow former colonized to reclaim the images of their own past at a time when there was a monopoly of audiovisual means of production. This would respond to a memorial, audiovisual and emotional justice
Ba, Emmanuelle. "Impact des médias sur l'émancipation des femmes au Sénégal. Approche historique (1960-2010)." Thesis, La Réunion, 2013. http://www.theses.fr/2013LARE0022.
Full textThe power of women in politics, before, during and after colonization, has not declined with the power of media. Through the associative life, women have managed to prevail by empowerment in civil society, despite the constraints of polygamy, excision and levirate marriage, since the time of independence in 1960. But with the informal trade, women come together to develop a strategy to escape. The emergence of a feminine power, could waver existing strengths. About polygamy, what could be more natural to have several wives for a Muslim, to the extent that religion encourages it. While ignorance of family planning, the repetition of birth, make them sick and destroyed the integrity of women. Regarding informal trade, becomes a lever of emancipation which affirm their social, economic empowerment and recognition of the society to care after for their ''Borom Kër'', the householder. The future is concentrated in associative areas in different villages. The group therefore allows women an education and a reduction of illiteracy. Awareness of their power over men is present in their work force. When Wolof woman managed to supplant her husband by informal trade, went to meetings of women, it's kneel and humbly ask her husband's permission. This allows him to leave. This is necessary, despite the economic independence of women. Its lower about the rights is important for the future of children. Vision of Senegalese culture, whom respect the man made it the spiritual guide and protector of all family
Buggenhagen, Beth Anne. "At home in the Black Atlantic : circulation, domesticity and value in the Senegalese Murid trade diaspora /." 2003. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3088718.
Full textMachado, Alison. "Fine mapping of susceptibility loci to malaria clinical episodes in a family-based cohort from Senegal." Master's thesis, 2010. http://hdl.handle.net/10400.14/16308.
Full textThe malaria parasite, P. falciparum, kills on the order of a million African children each year, and this is a small fraction of the number of infected individuals world-wide. The clinical outcome of an infection by this parasite depends to some extent on the genetic makeup of the infected individual. The role of genetic factors that regulate the severity of malaria infection has been repeatedly demonstrated in humans and animals. Association studies are conducted with the aim of identifying the causal genes implicated in the outcome of infection. Linkage was previously detected on human chromosome 5p15 controlling the number of Plasmodium falciparum attacks (PFA) in Dielmo, a Senegalese village [48]. Subsequently, and prior to this present study, a fine mapping study using a "GoldenGate assay” from Illumina, with about 1450 SNPs was performed in this region of linkage with PFA phenotype. Analysis was performed with three statistical family-based programs: Merlin, QTDT, and FBAT/PBAT. These programs identified three candidate genes associated with PFA phenotype: three SNPs (rs4867417, rs7714218, and rs11959398) located in PDZD2, one SNP (rs11134099) in ADAMTS16, and one (rs3777320) in SEMA5A. The aim of this present study was to investigate these associations. Novel SNPs in the candidate regions of these genes were selected either by sequencing exons located in these candidate regions or by bioinformatics analysis using HapMap data from Yoruba population. SNPs were studied using either Pre-design or Custom SNP genotyping assay (Applied Biosystems). Data were included in an Access Database and checked for error of Mendelian transmission. Statistical analyses were performed using two family-based association programs, PBAT and QTDT. We used different models of allele transmission and defined p=10-3 as significance threshold. The analyses did not confirm the association with SNPs of PDZD2 or ADAMTS16, but did find significant association with SNPs of SEMA5A. One SNP (rs3777325) was significantly associated with PFA phenotype using both programs (p-value= -6.49x10-4 using the PBAT program and p-value=2.0x10-4 using the QTDT program). A haplotype analysis of two adjacent SNPs (rs4541632 and rs1018956) also showed a significant association of the haplotype GC (p-value= -6.82x10-5) using the PBAT program. This work confirms that a susceptibility locus to PFA phenotype is located inside SEMA5A. Further studies will be necessary to replicate this association and identify the causal polymorphism.
Ndiaye, Khadidiatou Hecht Michael L. Parrott Roxanne. "When Soutoura (dignity, respect, and privacy) matters most understanding and assessing HIV/AIDS stigma in the family context in Senegal /." 2008. http://etda.libraries.psu.edu/theses/approved/WorldWideIndex/ETD-3143/index.html.
Full text