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March, Helen Nicola. "Regulation of AP-1 family proteins by MAP kinase pathways." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612889.
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Wronka, Agata Ewa. "Separatrix splitting for the extended standard family of maps." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5043.
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This thesis presents two dimensional discrete dynamical system, the extended standard family of maps, which approximates homoclinic bifurcations of continuous dissipative systems. The main subject of study is the problem of separatrix splitting which was first discovered by Poincaré in the context of the n-body problem. Separatrix splitting leads to chaotic behaviour of the system on exponentially small region in parameter space. To estimate the size of the region the dissipative map is extended to complex variables and approximated by differential equation on a specific domain. This approach was proposed by Lazutkin to study separatrix splitting for Chirikov’s standard map. Furthermore the complex nearly periodic function is used to estimate the width of the exponentially small region where chaos prevails and the map is related to the semistandard map. Numerical computations require solving complex differential equation and provide the constants involved in the asymptotic formula for the size of the region. Another problem studied in this thesis is the prevalence of resonance for the dissipative standard map on a specific invariant set, which for one dimensional map corresponds to a circle. The regions in parameter space where periodic behaviour occurs on the invariant set is known as Arnold tongues. The width of Arnold tongue is studied and numerical results obtained by iterating the map and solving differential equation are related to the semistandard map.
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Yang, Tun-Hsiang. "Family based liquid association study an approach to map the disease genes for the complex trait /." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1610653951&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.
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O’Connor, Teresia M., Louise C. Mâsse, Andrew W. Tu, Allison W. Watts, Sheryl O. Hughes, Mark R. Beauchamp, Tom Baranowski, et al. "Food parenting practices for 5 to 12 year old children: a concept map analysis of parenting and nutrition experts input." BIOMED CENTRAL LTD, 2017. http://hdl.handle.net/10150/625794.
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Background: Parents are an important influence on children's dietary intake and eating behaviors. However, the lack of a conceptual framework and inconsistent assessment of food parenting practices limits our understanding of which food parenting practices are most influential on children. The aim of this study was to develop a food parenting practice conceptual framework using systematic approaches of literature reviews and expert input. Method: A previously completed systematic review of food parenting practice instruments and a qualitative study of parents informed the development of a food parenting practice item bank consisting of 3632 food parenting practice items. The original item bank was further reduced to 110 key food parenting concepts using binning and winnowing techniques. A panel of 32 experts in parenting and nutrition were invited to sort the food parenting practice concepts into categories that reflected their perceptions of a food parenting practice conceptual framework. Multi-dimensional scaling produced a point map of the sorted concepts and hierarchical cluster analysis identified potential solutions. Subjective modifications were used to identify two potential solutions, with additional feedback from the expert panel requested. Results: The experts came from 8 countries and 25 participated in the sorting and 23 provided additional feedback. A parsimonious and a comprehensive concept map were developed based on the clustering of the food parenting practice constructs. The parsimonious concept map contained 7 constructs, while the comprehensive concept map contained 17 constructs and was informed by a previously published content map for food parenting practices. Most of the experts (52%) preferred the comprehensive concept map, while 35% preferred to present both solutions. Conclusion: The comprehensive food parenting practice conceptual map will provide the basis for developing a calibrated Item Response Modeling (IRM) item bank that can be used with computerized adaptive testing. Such an item bank will allow for more consistency in measuring food parenting practices across studies to better assess the impact of food parenting practices on child outcomes and the effect of interventions that target parents as agents of change.
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Raman, Malavika. "Identification of intracellular signaling pathways regulated by the TAO family of mammalian STE20p kinases." Access to abstract only; dissertation is embargoed until after 5/15/2007, 2006. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=163.
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Sixsmith, Jaimie. "Development of real time PCR to map poly(ADP-ribose) polymerase family gene expression in human brain tissue and cultured cells." Thesis, University of Newcastle Upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413948.
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Alvarez, Susana. "Interlaced Distortions." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1308186327.
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Chládeková, Paulína. "Zaměření rodinného domu v Brně Žabovřeskách." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2020. http://www.nusl.cz/ntk/nusl-414308.
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This diploma thesis is about measuring of family house, creating drawings and visualization of results. The family house is located in the Brno-Žabovřesky The house was surveyed by the classical geodetic method using a survey net built using GNSS (Global Navigation Satellite System). The results of field measurements were processed in the Groma program, graphic outputs (footprints of individual floors, sections and 3D model) in the MicroStation application. The documentation can be used mainly for the planned reconstruction of the family house and other related purposes.
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Bowles, Mollie Ellen. "Interactions Between Phytophthora spp. and Castanea spp. and the Creation of a Genetic Linkage Map for the F1 Parent in a First-Generation Backcross Family of Castanea spp." NCSU, 2006. http://www.lib.ncsu.edu/theses/available/etd-08162006-093218/.
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Efforts are underway to restore the American chestnut, Castanea dentata (Marsh.) Borkh, to its original range within the United States. The American Chestnut Foundation has traditionally focused on introducing blight resistance of the Chinese chestnut, C. mollissima Blume, into their breeding stock. Now, however, they are encountering problems with a root rot caused by Phytophthora cinnamomi Rands, and the threat of a potential disease caused by Phytophthora ramorum Werres, De Cock, and Man in?t Venld. In order for the Foundation to breed for resistance against the effects of these pathogens, much more needs to be discovered regarding their interactions within Castanea. This thesis is part of the effort to understand these interactions. The first chapter provides a literature review of interactions for two Phytophthora species and Castanea spp. The second chapter presents experiments investigating the mode of inheritance and number of loci controlling resistance to each of these Phytophthora species. Initial experimentation appears to suggest that resistance to P. cinnamomi may be controlled by a single dominant gene in chestnut, but conclusive evidence from subsequent experiments was not found; possible causes are discussed. A series of screening assays based on leaf disk assays using P. ramorum also failed to provide conclusive evidence that a single locus controls the degree of response, but statistically significant differences were noted among seedlots in each trial, suggesting some level of genetic control. The third chapter presents a genetic linkage map developed from amplified fragment length polymorphic (AFLP) markers for the F1 parent in a backcross family ((C. mollissima ?Mahogany? x C. dentata ?RCF1? = ?KY115?) x C. dentata ?WB348?). This purpose of this map is to correlate future resistance segregation patterns from controlled P. cinnamomi inoculation trials with specific marker loci. This would provide a foundation for future genetic research regarding the number of loci controlling resistance to root rot caused by P. cinnamomi and its relationship with other traits of interest in chestnuts.
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Durant, Richard P. "A Concept Mapping Needs Assessment of Young Families with Parental Cancer." Antioch University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=antioch1307109066.
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Maza, Paloma Korehisa [UNIFESP]. "Estudos sobre o envolvimento de “membrane rafts” e a ativação de quinases de células epiteliais durante a interação com paracoccidioides brasiliensis." Universidade Federal de São Paulo (UNIFESP), 2008. http://repositorio.unifesp.br/handle/11600/9604.
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Made available in DSpace on 2015-07-22T20:50:11Z (GMT). No. of bitstreams: 0
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Publico-Tese%20Paloma%20Korehiza%20Maza%20versao%20final.pdf: 1568579 bytes, checksum: 8a94eab5c79046acd8162d9a949d2c36 (MD5)Muitos patógenos são capazes de manipular a sinalização de células do hospedeiro para facilitar sua infecção. Nesta tese, demonstramos que o fungo Paracoccidioides brasiliensis promove um aumento na ativação de ERK1/2 e SFKs em células epiteliais A549 (de pulmão humano), de aproximadamente 6 e 7 vezes, respectivamente, em relação aos níveis basais. Utilizando PP2, inibidor da atividade de SFKs, e PD98059, inibidor da ativação da via ERK1/2, verificamos que a ativação de ERK1/2 é parcialmente dependente de SFKs ativadas e que provavelmente outras quinases também estão envolvidas neste evento. Além da modulação da sinalização de células do hospedeiro, diversos estudos têm demonstrado que patógenos seqüestram domínios presentes nas membranas da célula hospedeira denominados “membrane rafts”, os quais são enriquecidos em esfingolipídeos e colesterol e estão envolvidos em diversos eventos celulares, incluindo a sinalização celular. Por diferentes metodologias, como a desorganização de “membrane rafts” por drogas que extraem (metil-β- ciclodextrina, MβCD) ou que se ligam (nistatina) ao colesterol, e a localização do gangliosídeo GM1, um marcador de “membrane rafts”, utilizando a subunidade B da toxina da cólera (CTB), mostramos o envolvimento destes domínios de membranas de células epiteliais na adesão de P. brasiliensis. A partir do isolamento de membranas resistentes a detergente (DRMs) de células epiteliais após incubação com o fungo, mostramos a ativação e o deslocamento de SFKs para as frações que contêm os “membrane rafts”. Além disso, verificamos que a depleção do colesterol com MβCD inibe completamente a ativação de SFKs, corroborando a importância dos domínios de membranas para a ativação destas quinases. Os resultados apresentados nesta tese demonstram, pela primeira vez, que fungos patogênicos modulam a organização e a atividade de “membrane rafts” de células hospedeiras para o estabelecimento da infecção.
Many pathogens are able to manipulate host cell signaling in order to facilitate infection. In this thesis, we demonstrated that the fungus Paracoccidioides brasiliensis promotes an increase of ERK12 and SFK activation in A549 epithelial cells (human lung cells), by approximately 6- and 7-fold over basal levels, respectively. By using PP2, inhibitor for SFK activity, and PD98059, inhibitor for ERK1/2 activation, we verified that ERK1/2 activation is partially dependent of activated SFKs and probably other kinases are involved in this event. Besides modulation of host cell signaling, several studies have been demonstrated that pathogens hijack domains that are present in host cell membranes called membrane rafts, which are cholesterol- and sphingolipidenriched domains, that are involved in several cell events, including cell signaling. By using several approaches, such as membrane rafts disruption with cholesterolextractor (methyl-β-cyclodextrin, MβCD) or –binding (nystatin) drugs, and the localization of ganglioside GM1, a membrane raft marker, by using cholera toxin subunit B (CTB), we showed the involvement of these epithelial cell membrane domains in P. brasiliensis adhesion. By isolating detergent-resistant membrane (DRM) from epithelial cells after incubation with this fungus, we showed the activation and the dislodgment of SFKs to fractions which contain membrane rafts. Moreover, we verified that cholesteroldepletion with MβCD completely inhibits SFK activation, corroborating the importance of membrane domains in activation of these kinases.The results presented in this thesis demonstrate for the first time that pathogenic fungi may modulate the organization and activity of host cell membrane rafts for infection establishment.
TEDE
BV UNIFESP: Teses e dissertações
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Arvidsson, Oona, and Alexander Taubert. "”Man måste bli allt – man måste vara mamma, pappa, syskon, man” : En fenomenologisk studie om familjeåterförening för ensamkommande barn i Sverige." Thesis, Södertörns högskola, Socialt arbete, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-34172.
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Syftet i den här studien har varit att undersöka hur ensamkommande unga i Sverige beskriver sin upplevelse av familjeåterförening och vilken innebörd eller mening familjeåterföreningen har för dem. Vidare har vi haft för avsikt att ta reda på hur ensamkommande unga upplever den förändring som sker när samhällsstödet dras in vid familjens ankomst till Sverige. Studien är en kvalitativ intervjustudie där vi intervjuat tre personer som kommit till Sverige som ensamkommande barn och som senare återförenats med sina familjer i Sverige. Studiens teoretiska ramverk utgörs av Schütz fenomenologiska sociologi samt Berger och Luckmanns teori om den sociala verkligheten. För att ytterligare fördjupa förståelsen har vi kompletterat det teoretiska ramverket med Boss teori om tvetydig förlust samt med Greifs teori om tvetydig återförening. Analysmetoden var interpretativ fenomenologisk analys (IPA). Studiens huvudsakliga resultat är att det verkar finnas en kluvenhet i ensamkommande ungas upplevelser av familjeåterföreningen. Samtidigt som familjeåterföreningen har haft stor betydelse för respondenterna, har tiden efter återföreningen präglats av ett påfrestande ansvar över familjen. Avslutningsvis diskuteras eventuella brister i socialtjänstens stöd för familjer vid familjeåterförening i Sverige.The purpose of this study was to explore how unaccompanied minors describe their experiences of family reunification, and what importance or implications it has for them. Furthermore, our aim was to find out how they experience the withdrawal of public social support after the arrival of their families. We interviewed three persons who were unaccompanied minors by the arrival to Sweden, and later reunified with their families in Sweden. The theoretical framework of this qualitative interview study is formed by Schütz’ phenomenological sociology and Berger and Luckmann’s theory of the social construction of reality. We complemented the theoretical framework with Boss’ theory of ambiguous loss and Greif’s theory of ambiguous reunification. The method for analysis used is Interpretative Phenomenological Analysis (IPA). The main results shown in this study is that there seems to be an ambiguity in the family reunification experience. On one hand, the family reunification was of big importance to the participants. On the other hand, the time following the reunification was characterized by a great responsibility for the family. Finally, we discuss possible shortcomings in the way the public social support for families after family reunification is provided.
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Hultin, Hanna. ""Även om man inte blir exakt som vilken annan familjsom helst" : En kvalitativ studie om föreställningar kring familjehemsuppdraget." Thesis, Linnéuniversitetet, Institutionen för socialt arbete (SA), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-64808.
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The aim of this study was to gain a better understanding of possible foster families’ views on fostering a child and what they consider to be important factors for deciding whether or not to become a foster family. The studys result is based on five semi-structured interviews with persons whom have an interest for becoming foster families and the findings were analyzed by using a norm theory. The way that the interviewed people described their views on fostering a child could in the analysis be seen as a result of different norms and they often described the ideal foster family based on either their own family or the nuclear family.
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Gresh, Kristen Ann. "The Family of man : histoire critique d'une exposition américaine." Paris, EHESS, 2010. http://www.theses.fr/2010EHES0132.
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En 1955, Edward Steichen organise l'exposition monumentale «The Family of Man» au Museum of Modem Art (MoMA) à New York, qui a été ensuite exposée dans le monde entier sous les auspices de l’United States Information Agency. L'objectif principal de cette thèse est de retracer les arcanes de cette exposition afin de créer un document de référence dévoilant sa nature concrète. Cette démystification de l'exposition a été conçue à partir de témoignages directs de photographes participants recueillis par l'auteur, complétée par un travail d'analyse de documents d'archives inédits. La première partie s'interroge sur les programmes du Musée lors de la Seconde Guerre mondiale qui ont préparé le terrain pour «The Family of Man», sur le personnage de Steichen et sur son rôle de directeur du département de la photographie du MoMA. La deuxième partie remonte aux prémices du projet, afin d'éclaircir les diverses collaborations de Steichen, comme de nombreuses correspondances, des réunions collectives, et un voyage déterminant en Europe. La troisième partie met en lumière les méthodes et les résultats du travail de Steichen, à la fois comme photographe et comme éditeur. A l'appui d'une discussion des sources, notamment journalistiques, les contours du monde de la photographie de presse à l'époque sont esquissés, suivis d'une synthèse de l'exposition et de sa diffusion à l'étranger en plusieurs versions. Ce travail révèle que «The Family of Man», à la fois véritable prouesse de la photographie et arme de propagande, témoigne de toute une chaîne de contacts et de connaissances au sein du monde de la photographie et de la politique, et des croisements entre ces deux mondesIn 1955, Edward Steichen organized the historic exhibition "The Family of Man" at the Museum of Modem Art (MoMA) in New York. Under the auspices of United States Information Agency, it was exhibited throughout the world and gained a mythic status. This dissertation looks beyond that myth, in order to present a reference document with background information not previously examined. It is based on the author's research involving personal interviews with photographers who contributed to the exhibition as well as the analysis of unpublished archival documents. Part 1 explores the MoMA's World War II programs that paved the way for "The Family of Man", Steichen's career and his role as director of the museum's photography department. Part II traces the origins of the project, showing Steichen's various collaborations through a thorough examination of his correspondence, his individual and group meetings with photographers, and, in particular, his decisive trip across Europe. Part III examines the methods and results of Steichen's work, as both photographer and editor. A discussion of the sources of "The Family of Man", mainly photojournalistic, illustrates the contours of press photography at the time followed by a synopsis of the exhibition and its international circulation, in several versions. This dissertation demonstrates how "The Family of Man" was a tour de force in the history of photography because of Steichen's ability to combine his innovative photographic and editing skills that exploited the medium to communicate a political agenda that is a reflection of a complex network of colleagues, friends and acquaintances from the world of photography and of politics
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Jasaitis, Audrius. "Electrogenic reactions in the heme-copper oxidase family of enzymes." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/mat/bioti/vk/jasaitis/.
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Kukkonen, Maini. "Structure-function relationships in the omptin family of enterobacterial proteases /." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/mat/bioti/vk/kukkonen/.
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Louk, Tyler M. "An intergroup perspective on family targeted hurtful messages used in romantic relationships." Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5796.
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Thesis (M.A.)--West Virginia University, 2008.Title from document title page. Document formatted into pages; contains v, 49 p. Vita. Includes abstract. Includes bibliographical references (p. 32-38).
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Cederholm, Tova, and Maja Hagström. "”Det är något man läser om på högskolan” : En kvalitativ studie om socialarbetarens syn på arbetet med stigmatisering och stämpling." Thesis, Högskolan Dalarna, Institutionen för hälsa och välfärd, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:du-36450.
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Tidigare forskning gällande insatsbeviljade familjer visar på att klienterna är stigmatiserade eller stämplade. Syftet med studien är att undersöka, bland socialarbetare inom barn- och familjeenheten, medvetenheten om och arbetet med stigmatisering och stämpling gällande de familjer de har kontakt med i sitt arbete inom socialtjänsten. Stigmateori och stämplingsteori utgjorde studiens teoretiska tolkningsram. Studien genomfördes med en kvalitativ ansats i form av sex semistrukturerade intervjuer som sedan analyserades med hjälp av en tematisk analys vilket härledde till två teman: bortprioriterat arbete och indirekt arbete. Studiens resultat visade på att medvetenheten hos socialarbetarna om risken att klienterna var stigmatiserade och stämplade var låg. Det saknades riktlinjer och rutiner gällande ämnet och att arbetet som gjordes för att stödja familjerna var indirekt och inte preciserat för bearbetning av stigmatisering och stämpling. Slutsatsen drogs att en ökad medvetenhet bland socialarbetarna som möter familjer inom socialtjänsten gällande risken att familjerna stigmatiseras och stämplas behövs.Previous research has shown that families receiving interventions from the social services are stigmatized and labeled. The purpose of this study is to examine, among social workers within the family unit’s awareness of and work with stigmatization and labeling regarding the families they meet in their work. Stigma and labeling theory make up the theoretical framework for the study. It was conducted with a qualitative approach with six semi-structured interviews, the data was analyzed with a thematic analysis. Two themes emerged: de-prioritized work and indirect work. The results showed that the social workers awareness about family’s risk of being stigmatized and labeled was low. Guidelines and routines were missing and the work to support the families was indirect and not specified for processing stigma and labeling. It was concluded that there needed to be a greater awareness of the stigmatization and labeling of the clients among the social workers.
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McClure, Sarah A. "Using cognitive mapping to describe the family members experiences of living with a problem gambler." access full-text online access from Digital Dissertation Consortium, 2006. http://libweb.cityu.edu.hk/cgi-bin/er/db/ddcdiss.pl?1439658.
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Thesis (M.P.H.)--Southern Connecticut State University, 2006.Page(s) missing in number only; text follows. Page(s) were scanned as received. Adviser: Sandra Bulmer. Includes bibliographical references.
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Rice, Jerome Lee. "Examining Family Hierarchy Through the Eyes of Former Mac Baller Gang Members." ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/7952.
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Criminal gang membership is growing, which corresponds to a continued breakdown of the family unit in the United States. Most of the young people who form gangs come from broken families or single-parent-headed households. This study explored the role of family hierarchy on gang membership. A qualitative case study approach was used to gather information on what motivates young people to join criminal gangs. A random sampling technique was used to recruit seven former members of the Mac Baller Brim gang. Ethical concerns were addressed to minimize the risks to the participants. The collected data from interviews were analyzed using an interpretive research philosophy to determine the contribution of family hierarchy on motivating the participants to join gangs. Interpretive research philosophy indicates that reality can only be understood by subjective interpretation and intervention. An action research strategy was also used in an attempt to provide a practical solution for the people studied while adding to existing theories. The findings of the study indicated that there are 5 reasons why young people join gangs: protection, respect, money, fun, and because a friend was in the gang. This study may contribute to social change by identifying factors that lead to gang membership to aid policy and program interventions that lower the likelihood of youth joining gangs.
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Tsuchiyama, Yoko. ""The Family of Man" : la réception de l'exposition de 1955 jusqu'à aujourd'hui." Thesis, Paris Sciences et Lettres (ComUE), 2018. http://www.theses.fr/2018PSLEH104.
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L’exposition The Family of Man d’Edward Steichen a été initialement présentée au MoMA en 1955. Cette thèse porte sur sa réception depuis sa création en 1955 jusqu’à aujourd’hui, grâce à sa réinstallation au Château de Clervaux au Luxembourg depuis 1994. Dans les années 1950 et 1960, l’exposition a été présentée dans le monde entier. Comment l’exposition The Family of Man a-t-elle été perçue dans certains pays où l’exposition itinérante a été présentée de 1955 à 1964 ? Comment a-t-elle été réinstallée depuis les années 1990 au Luxembourg dans un nouveau contexte ? Pourquoi a-t-on continué à produire du discours sur l’exposition alors qu’elle avait disparu en tant qu’objet entre ces périodes ? En effet, des réactions sur l’exposition avaient émergé dans la presse au moment de l’exposition itinérante. Aujourd’hui, l’exposition est visible grâce aux objets matériels reproduits des années 1950 et aux documents archivés en plus de la consultation du catalogue. Cela permet au spectateur d’expérimenter l’exposition réellement de son point de vueThe Family of Man exhibition of Edward Steichen was organized at MoMA in 1955. This thesis addresses the reception of The Family of Man from its creation in 1955 until today, thanks to the reinstallation of the exhibition in the Clervaux Castle in 1994. In the 1950s and 1960s, the exposition was shown in 38 countries. How was The Family of Man exhibition received in certain countries where the itinerant exhibition was shown from 1955 to 1964? How was it reinstalled in the 1990s in Luxembourg in a new context? Why was discourse on the exhibition produced between the two periods when it was no longer there as an object? In fact, there had been reactions to The Family of Man at the time of the itinerant exhibition. Today, the exhibition is visible thanks to the material objects reproduced in the 1950s and the archived documents in addition to the consultation of the catalogue. This allows the spectators to have an actual experience of the exhibition by themselves from their point of view
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Curbilié, Camille. "Processus identitaire adolescent en mal de filiation : quels liens et quels lieux pour devenir ?" Thesis, Paris 10, 2015. http://www.theses.fr/2015PA100057.
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Les fonctionnements psychopathologiques de certains adolescents nés en France (de parents migrants) et placés dans des institutions éducatives, relèvent de souffrances identitaires qui ne peuvent être comprises en dehors du contexte socioculturel de la situation familiale et institutionnelle. La perte des repères socioculturels lors de la migration parentale, la séparation induite par le placement éducatif ainsi que les réaménagements identificatoires et pulsionnels de l’adolescent interrogent en profondeur la dynamique des temps de passages. Il est apparu que la séparation originaire de la migration résonne avec la séparation du placement empêchant le sujet d’accéder aux objets qui fondent ses origines et donc son devenir. Ces jeunes sont comme exclus d’une filiation, dans l’incapacité d’accéder à une historisation. Ils cherchent par eux-mêmes (en marge) des référentiels privés, les excluant d’une subjectivité reconnue et partagée par le reste de la société. Ils signent ainsi une difficulté d’accéder à des idéaux collectifs dont le surmoi culturel se fait normalement le représentant psychique. La destructivité des relations objectales révèle une conflictualité intrapsychique, transgénérationnelle et institutionnelle qui nous oblige à articuler subjectivité et collectivité pour penser la multiplicité du traumatisme. Une réflexion sur une clinique de terrain ainsi que sur les dispositifs de prise en charge a pu être menée en lien avec la spécificité des souffrances identitairesThe psychological functions of certain teenagers born in France and placed in educational institutions, reveals identity sufferance which cannot be understood outside of the sociocultural family’s and institution’s context. The loss of sociocultural references during parental migration, the separation induced by educational placement just as the teenager’s identity and drive reorganization deeply questions the “ temps de passage”. It appears that the original emigrational separation resonates with the placement separation, preventing the subject access to objects, which are the basis for their origins and therefore their future. These young people are just like excluded from filiations, incapable of reaching “historisation”. They search by their own means private references, excluding them from admitted subjectivity, shared by the rest of society. In this way they mark a difficulty to access collective ideals in which the cultural superego normally acts as the psychological representative. “Objectales” relational destructivity reveals intra-psychological, trans-generational and institutional conflict that obliges us to articulate subjectivity and collectivity in order to apprehend the multiplicity of trauma. A reflection based on clinical ground, along with care measures has been lead linked with the specificity of identity sufferance
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Kimbrough, Wynne A. ""If a man know not how" an examination of the minister's family life /." Online full text .pdf document, available to Fuller patrons only, 1999. http://www.tren.com.
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Wikström, Maria, and Anna Möllerstrand. "En familj är att man är bra ihop – en diskursanalytisk studie av regnbågsbarns prat om familj och tillblivelse." Thesis, Linköpings universitet, Institutionen för beteendevetenskap och lärande, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-70367.
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Denna studie kan placeras inom barndomsforskningen, där barn ses som aktörer vars röster förtjänar att tas på allvar. Syftet var att undersöka regnbågsbarns syn på familj, sin egen familj och tillblivelse. Intervjuer har genomförts med tolv barn i åldern fem till åtta år som alla var samboende med två mammor. En semistrukturerad intervjuguide användes och barnen ombads att måla sin egen och en annan familj. Barnens tal har analyserats utifrån en diskursanalytisk ansats. Resultatet visar att regnbågsbarnen pratar om familj utifrån relationella band, emotionell närhet, att man bor och gör saker tillsammans. Barnen visar en öppenhet inför olika familjestrukturer. Föräldrar beskrivs som omhändertagande och mammors och pappors funktion sägs vara likvärdig. Pratet om den egna familjen och mammorna präglas av positiva beskrivningar men utmanas i ett fåtal berättelser genom att teman av konflikt lyfts. Majoriteten av barnen pratar om pappor och beskriver dessa dels utifrån ursprung och dels utifrån en relationell mening. En del barns prat framstår förvirrat kring dessa två aspekter av pappor. Barnen uppvisar svårigheter att närma sig prat om tillblivelse och använder begreppen frö och ägg i olika utsträckning. Majoriteten av barnen som pratar om frö berättar att det kommer från en man. Regnbågsbarnens sätt att prata om familj är i linje med tidigare forskning om barns syn på familj. Barnens öppenhet inför olika familjestrukturer kan ses som ett uttryck för att rättfärdiga den egna familjekonstellationen, alternativt visar det på en realistisk spegling av samhällets mångfald vad gäller familjeformer. Svårigheterna att prata om negativa erfarenheter inom den egna familjen visar på det problematiska att gå emot en dominerande diskurs av familj som harmonisk. Regnbågsbarnens prat kring att mammor och pappor är samma sak skiljer sig från tidigare forskning om barns syn på föräldrar och hur detta kan förstås diskuteras i uppsatsen. Den förvirring som en del barns prat kring att i en mening ha en pappa och i en annan inte, kan visa på att barnen behöver få stöd i att hitta en fungerande diskurs om vad en pappa är och skillnaden på en relationell pappa och en donator.
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Butler, Jonathan Alexander. "Characterisation of the Campylobacter jejuni motility accessory factor (maf) gene family involved in flagellin glycosylation." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.518480.
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Lennmyr, Fredrik. "Signal Transduction in Focal Cerebral Ischemia : Experimental Studies on VEGF, MAPK and Src family kinases." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5267-1/.
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Walti, Lee. "A practical theology on the doctrine of repentance in the life of a family man." Theological Research Exchange Network (TREN), access this title online, 2006. http://www.tren.com/search.cfm?p091-0060.
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O'Hara, Shifawn R. K. "The Effects of HIV on the Regulation of IL-12 Family Cytokines, IL-12, IL-23, and IL-27 Production in Human Monocyte-derived Macrophages." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23220.
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IL-12 family cytokines IL-23 and IL-27 play an important role linking innate and adaptive immunity, and regulating T-cell responses. The production of IL-12, a structurally similar cytokine, is decreased in chronic HIV infection; therefore IL-23 and IL-27 may also be influenced by HIV infection. I hypothesized that HIV inhibits LPS-induced IL-23 and IL-27 production in human MDMs by suppressing the activation of signalling pathways regulating their expression. In vitro HIV-infection of MDMs did not have any effect on basal secretion of IL-23 or IL-27; however, HIV inhibited LPS-induced production of IL-12/23 p40 and IL-23 p19, and IL-27 EBI3 and IL-27 p28 mRNA expression, and IL-23, IL-12/23 p40 and IL-27 secretion. In order to evaluate the molecular mechanisms by which HIV inhibits IL-23 and IL-27 in LPS-stimulated MDMs, the signalling pathways regulating their expression were evaluated. The PI3K, p38 MAPK, and JNK MAPK pathways were found to positively regulate LPS-induced IL-27 secretion. Interestingly, in vitro HIV infection inhibited LPS-induced p38 and JNK MAPK activation in MDMs. In summary, I have shown that HIV inhibits IL-23 and IL-27 production in LPS-stimulated MDMs and that HIV may inhibit LPS-induced IL-27 production through the inhibition of p38 and JNK MAPK activation. It is currently unknown whether PKCs regulate LPS-induced IL-23 or IL-27 in human monocytes/macrophages. I demonstrated that classical PKCs differentially regulate LPS-induced IL-23 and IL-27 secretion within THP-1 cells, primary monocytes, and MDMs. Classical PKCs were found to positively regulate LPS-induced IL-12/23 p40 and IL-27 p28 mRNA expression and IL-12/23 p40, IL-23, and IL-27 secretion in primary human monocytes. Similarly, the classical PKCs were found to positively regulate IL-27 p28 mRNA expression and IL-27 secretion in THP-1 cells. However, classical PKCs did not regulate LPS-induced IL-27 production in MDMs, or LPS-induced IL-23 production in THP-1 cells. Overall, this demonstrates that classical PKCs differentially regulate LPS-induced IL-23 and IL-27 production in different myeloid cells.
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Turner, Elizabeth C. "Acting like a man : a critical investigation into the performance practices of the seduction community." Thesis, University of Warwick, 2013. http://wrap.warwick.ac.uk/59919/.
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This thesis sets out to investigate the techniques and strategies used by members of the seduction community to perform masculinity, using as its primary sources material produced by the community ranging from published texts to online commentary. The research is interdisciplinary and incorporates theoretical frameworks drawn from performance studies, semiotics and cultural studies, sociology, literary theory and gender studies. The first chapter explains the origins and operations of the seduction community, positioning it as a force that regulates performances of masculinity and depends upon teamwork and co-operation in order to function. The second chapter discusses the community's dual understanding of masculinity as a construct open to adaptation and change, and also as an innate and natural category. This tension is addressed through an analysis of power relations evident through narcissism and self-display, and a reliance on the suppression of non-masculine elements through homosociality, and performances of leadership based upon embodied expertise. This leads me to conclude that the seduction community may be a heterosexual pretext for building fulfilling homosocial relations. The final chapter addresses how women and femininity are imagined in the community, specifically as inferior and in many ways incomplete without masculine intervention, an attitude which reflects broader social trends. Of particular importance here are the devaluation of female speech and sexuality and the imagining of sex as a commodity. The thesis argues that where women themselves appropriate the language and techniques of the seduction community, this is presented as complicity with conventional gender norms, but also a potential route to individual empowerment through learning to manage relationships more effectively.
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Lam, Yeung-Yin. "Resolving disputes within the family of problem gambler in Hong Kong." access abstract and table of contents access full-text, 2006. http://libweb.cityu.edu.hk/cgi-bin/ezdb/dissert.pl?ma-slw-b21847666a.pdf.
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Thesis (M.A.)--City University of Hong Kong, 2006."Master of Arts in arbitration and disputes resolution [MAArbDR]" Title from PDF t.p. (viewed on May 23, 2007) Includes bibliographical references.
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Oredsson, Susanna. ""Man kan säga att båda sänder signaler men på olika frekvenser" : en kvalitativ studie om partners upplevelse av att vara i ett parförhållande där den andra partnern har Aspergers syndrom." Thesis, Högskolan Kristianstad, Sektionen för hälsa och samhälle, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-11089.
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Being in a relationship where the partner has Asperger's syndrome makes you indirectly affected by their disability as it affects not only the disabled but also the partner. The partner may be faced with a lack of understanding from their partner with Asperger's syndrome and from its surroundings, where the syndrome including causes, limits ability in social interaction and communication. The study is a qualitative study based on six asynchronous interviews conducted via email with partners who are in a relationship with a partner who has Asperger's syndrome. The aim of the study was to increase understanding and to highlight partners experience to be in a relationship where the other partner has Asperger's syndrome and how outside support from the environment is perceived. Results of the study showed that all six partners felt that everyday life was structured around the partner with Asperger's syndrome. There was a perceived feeling of loneliness because of the partner with Asperger's syndrome not caring about the partner and of being the one taking the greatest responsibility in everyday life for it to work. There was a feeling of stress, anxiety, lost confidence and frustration but there was also a strong desire and commitment to their partner with Asperger's syndrome. There was a strong love for the partner with Asperger's syndrome and a willingness to get the couple relationship to work. The results show that partners need and want support from the environment. It is important that they receive the support they need. The type of support needed varies but the important thing is that it is flexible, tailored and personalized for the couple or the individual partner's needs. The results indicate that there is a benefit for the couple relationship when the partner with Asperger's syndrome has a diagnosis. Both parties can thus get a better understanding of why certain things are the way they are and then work from there.
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Pflieger, Jacqeline Cornett. "Parental processes and young adults' romantic relationships in traditional, divorced, and remarried family structures." Auburn, Ala., 2005. http://repo.lib.auburn.edu/2005%20Summer/master's/PFLIEGER_JACQUELINE_6.pdf.
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Zhao, Xianjie. "Mediation a popular choice of dispute resolution in family problems : an analysis of reasons, advantages and practice in mainland China and Hong Kong /." access abstract and table of contents access full-text, 2007. http://libweb.cityu.edu.hk/cgi-bin/ezdb/dissert.pl?ma-slw-b22052422a.pdf.
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Thesis (M.A.)--City University of Hong Kong, 2007.Title from PDF t.p. (viewed on Sept. 7, 2007) "LW6409A, dissertation of MA arbitration and dispute resolution" Includes bibliographical references.
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Mulcahy, Lori Ann. "MAPK regulation of DC IL-12 family is exploited by melanoma to subvert Th-1 priming." Thesis, University of Nottingham, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490963.
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Effective anti-cancer responses are mediated by an IFN-y and Twi type immune profile. Crucial to the induction of IFN-y are the cytokines Il-27 and Il-12. Il-27 initiates Twi differentiation from naive T-cells and Il-12 quickly takes over to drive IFN-y and expand the TH-i population. Dendritic cells (DC) present antigen and instruct lymphocytes, this role places them at the apex of adaptive immunity. They are the major source of Il-12 and Il-27. DC conditioning by the microenvironment upon antigen uptake significantly alters both the resultant cytokine response and T-cell polarisation The tumour microenvironment is a.unique compartment where a high concentration of pro-angiogenic and inflammatory suppressor modulators are concentrated. It is in this region that DC encounter tumour antigens and inflammatory signals are switched off. Il-12 is inhibited in patients of melanoma and other tumours and the underlying molecular mechanisms are of considerable interest to cancer immunologis~s. Here the investigation of melanoma mediated Il-12 suppression revealed that both Il-12 and Il-27 are targeted. Cytokine inhibition directly limits T-ceIlIFN-y release and the TH-l population size, reinforcing the central role of Il-12 in anticancer responses. Il-12 is highly regulated and there are several mechanisms able to switch off IL-12 expression. Melanoma acts in an Il-iO independent manner and does not alter global phenotypic DC maturation. Selected TLR ligands and pathogen derived molecules activate the MAPK ERK pathway and down-regulate IL-12 in a manner strikingly similar to melanoma. Investigation of the MAPK revealed hyper-activation of ERK is responsible for IL- 12 suppression and using a specific inhibitor of ERK recovers melanoma suppressed IL-12 expression from DC. This work is the first to demonstrate that a signalling pathway used to regulate inflammation and exploited by pathogens is also.a mechanism of tumour immune escape. One of the major hurdles for effective DC based immunotherapy is functional inhibition in the tumour setting. This work suggests that the application of ERK inhibitors, already clinically approved, could be a useful tool in overcoming this issue.
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De, Bruyn Paul Jacobus. "'n Pastoraal-teologiese studie oor die roeping van die Afrikaanssprekende man tussen die ouderdom van 30-40 in die gesin, kerk en samelewing / Paul Jacobus de Bruyn." Thesis, North-West University, 2004. http://hdl.handle.net/10394/660.
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The aim of this study was to look at the vocation of the Afrikaans-speaking male between 30
and 40 years within the family, church and society. The following procedure was followed:
A base theoretical investigation was undertaken to establish Scriptural perspectives
on the subject. The model of Zerfass was used.
It was found:
The male as representative of God on earth must live in an intimate personal relationship
with God. He should therefore be peacemaker, acting in love towards all, even his enemies.
A man should accompany his wife as his equal with unconditional sacrificial love so that she
is able to grow spiritually. His family should be the highest priority in his daily programme.
Metatheoretical perspectives were subsequently obtained from the two disciplines,
namely Psychology and Sociology. An empirical study was simultaneously undertaken
in order to determine the shortcomings in a man's life.
The following conclusions were made:
The male between 30 and 40 years-old is in a phase where he critically evaluates certain
religious systems and values.
The male between 30 and 40 years regards his marriage and family as one of his four
"enemies" because it feels as if his family expects too much of him.
The male between 30 en 40 years also struggles to maintain a balance between time at work
and time with his family.
Theoretical guidelines from practice were subsequently established by synthesising the
above information in an hermeneutical way.
The following guidelines were set:
Through the love of Christ a man should be "the salt of lie" to counteract perdition and a
"light for this world" to indicate direction in life.
A husband should make time for his family in order to spend quality time with them. His
behaviour and the way that he communicates with them will show them that he loves them,
appreciates them and understands them.
A man should do his work as if were doing it for Christ, and not for people. This, however,
means that he should work in such a way that he does not lose valuable time that he could
have spent with his family.
A man must be aware of his own sinful nature and continuously profess his sins before God
and his neighbour.
This study aimed to give men a vision so that they would have a conception of what it means
to be a man of God in a troubled world.Thesis (M.Th. (Pastoral))--North-West University, Potchefstroom Campus, 2005.
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Lyle, Timothy Scott. ""Check with Yo' Man First; Check with Yo' Man": Perry Appropriates Drag as a Tool to Recirculate Patriarchal Ideology." Atlanta, Ga. : Georgia State University, 2009. http://digitalarchive.gsu.edu/english_theses/52/.
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Thesis (M.A.)--Georgia State University, 2009.Title from title page (Digital Archive@GSU, viewed June 8, 2010) Shirlene Holmes, Kameelah Martin Samuel, committee co-chairs; Chris Kocela, committee member. Includes bibliographical references(p. 85-87).
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Broodo, Beth (Beth Lauren). "Influence of Family Environment on Ease of Discussion of Sexual Issues With a Partner." Thesis, University of North Texas, 1995. https://digital.library.unt.edu/ark:/67531/metadc277679/.
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The purpose of the present study was to investigate the relationship between ease of discussion of sexual likes and dislikes with a sexual partner and religious, expressive, and affectional influences in the family of origin.
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Qurik, Yvonne. "”Om man börjar från början”. Litteracitetspraktiker i flerspråkiga familjer med små barn." Thesis, Högskolan i Borås, Institutionen Biblioteks- och informationsvetenskap / Bibliotekshögskolan, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-17553.
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The aim of this master thesis is to investigate how parents’ in multilingual families perceive language learning and reading for young children, and how their practice of this can be understood in relation to their language situation and cultural background.This study focuses on the interaction between parents’ and young children in the light of the literacy practice. Important concepts such as early childhood literacy and family literacy have been used to study language, culture and literacy practice as phenomena that interact. The theoretical framework is a sociocultural perspective. Through qualitative interviews with seven parents’, it was found that multilingual families have a strong ambition for their children to learn all the languages spoken in the family. They also have a high ambition to read to their children. The ability to do so is not proportional the circumstances to give children a good start at an early age by consciously practicing language and reading to the child in the mother tongue. Lack of access to books in the mother tongue is one of the reasons. Some also prefer reading Swedish books in order to practice Swedish. Another reason is an ambivalent attitude to which order the languages in the family should be prioritized. Considering cultural aspects, the parents’ childhood memories of literacy practices from their background is linked to factors such as parents’ who are illiterate, lack of reading, but also rich oral storytelling traditions.Program: Masterprogram: Biblioteks- och informationsvetenskap, Digitala bibliotek och informationstjänster
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Sánchez, Mir Laura. "Control diferencial de la ruta de MAP quinasas de integridad celular por GTPasas de la familia Rho en Schizosaccharomyces pombe." Doctoral thesis, Universidad de Murcia, 2014. http://hdl.handle.net/10803/277324.
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Tesis por compendio de publicacionesLas rutas de señalización mediadas por MAP quinasas (MAPK) tienen un papel fundamental en la respuesta de células eucariotas frente a estímulos ambientales. La levadura con fisión Schizosaccharomyces pombe representa un modelo particularmente adecuado para abordar estudios básicos sobre dichas rutas de señalización, debido a la gran homología funcional que existe entre sus circuitos reguladores y los de organismos superiores. En S. pombe, la ruta de MAPKs de integridad celular (CIP) participa en la regulación de numerosos procesos biológicos como la construcción de la pared celular, la citocinesis, la morfogénesis, la fusión de vacuolas durante el estrés hipotónico, y la homeostasis iónica mediante la modulación de la activación de la MAPK Pmk1 en respuesta a cambios en las condiciones ambientales. Aunque la GTPasa Rho2 es el principal activador de la ruta de integridad celular a través del ortólogo de PKC Pck2, Pmk1 puede ser activada en ausencia de ambos dependiendo de la naturaleza del estímulo recibido, lo que indica la existencia de elementos reguladores adicionales aguas arriba del módulo de MAPKs. Se ha propuesto a la GTPasa Rho1 como candidata para tal función, mientras que el ortólogo de PKC Pck1 parece regular negativamente la actividad de la CIP. Hemos investigado el posible papel de Rho1 y Pck1 como reguladores de la CIP empleando un mutante hipoactivo de Rho1 (rho1-596) y un mutante carente de Pck1 en distintos fondos genéticos. Las evidencias obtenidas mostraron que Rho1 y Pck1 son activadores de la ruta adicionalmente a Rho2 y Pck2, lo que pone de manifiesto la naturaleza ramificada de los mecanismos de señalización que actúan aguas arriba del módulo de MAPKs. Por otra parte Rho2 se localiza en la membrana plasmática y en el área de división celular, y es farnesilada in vivo en el motivo -CAAX de su extremo C-terminal, siendo esta modificación esencial para su localización y función activadora de la CIP. Sin embargo, la presencia de un residuo de cisteína previo al motivo -CAAX sugiere que Rho2 podría encontrarse palmitoilada en dicho residuo. Para estudiar la relevancia biológica de la palmitoilación de Rho2 creamos una serie de cepas que expresan versiones mutantes tanto de Rho2 como de Rho1 afectadas en lipidación, y estudiamos su localización y función biológica. Los resultados obtenidos permitieron concluir que en la levadura con fisión, la GTPasa Rho2 es palmitoilada in vivo, siendo esta modificación crítica para su correcta localización en membrana plasmática y para ejercer su regulación de la morfogénesis y la ruta de integridad celular. Por último, son numerosos los estudios que han puesto de manifiesto la importancia de la localización subcelular de los componentes de los módulos de MAP quinasas en la respuesta a estrés. En el caso de la ruta de integridad celular, la MAPK Pmk1 muestra una localización núcleo/citoplasmática constitutiva, así como en el huso mitótico, el corpúsculo polar del huso, y en el septo durante la separación celular. Sin embargo, a diferencia del modelo descrito en ERK1/2 en mamíferos, el patrón de localización de Pmk1 no se modifica en respuesta a estrés, lo que indica que tanto la forma activa como inactiva de la MAP quinasa son capaces de entrar en el núcleo. En base a esto, nos planteamos el estudio de la relevancia biológica de la localización nuclear de Pmk1 sobre su función biológica. Para ello recurrimos a la caracterización de mutantes de S. pombe que expresan una versión de Pmk1 anclada a la membrana plasmática y excluida del núcleo constitutivamente en distintos fondos genéticos. Los resultados mostraron que aunque la localización nuclear de Pmk1 en Schizosaccharomyces pombe no es crítica para ejercer la mayor parte de sus funciones biológicas, sí es necesaria para la regulación transcripcional en respuesta al estrés de pared celular, lo que revela la importancia del control espacio-temporal de la actividad de las MAPKs en los organismos eucariotas.
SUMMARY Mitogen-activated protein kinase (MAPK) signaling pathways play a fundamental role in the response of eukaryotic cells to environmental changes. Fission yeast Schizosaccharomyces pombe has emerged as an excellent model organism to study mechanisms and cellular events linked to MAPK activation, given the significant functional homology between their regulatory circuits and those of higher cells. In S. pombe the cell integrity pathway (CIP) participates in multiple biological processes like cell wall construction, vacuole fusion during hypotonic stress, cytokinesis, morphogenesis, and ionic homeostasis by fine tuning of MAPK Pmk1 activation in response to various environmental conditions. Although the small GTPase Rho2 is a main positive regulator operating upstream the CIP through protein kinase C ortholog Pck2, Pmk1 can still be activated in the absence of either Rho2 or Pck2 depending on the nature of the stimulus, suggesting the existence of additional upstream regulatory elements to modulate its activity. The essential GTPase Rho1 is a candidate to control the activity of the CIP, whereas Pck1 appears to negatively regulate Pmk1 activity. To study the role of Rho1 GTPase and PKC ortholog Pck1 in the CIP, we characterized a S. pombe mutant that expresses hypomorphic Rho1 allele (rho1-596) and a mutant lacking Pck1 in distinct genetic backgrounds. The evidences obtained in this study revealed that Rho1 and Pck1 are positive upstream activators of the CIP in addition to Rho2 and Pck2 during cell growth and cell wall stress. This model shows the branched nature of the upstream signal network that regulates the CIP. Rho2 positively regulates the CIP and is involved in the control of cell polarity and cell wall biosynthesis in fission yeast. Rho2 locates along the plasma membrane and the division area and it has been described that becomes farnesylated in vivo at its -CAAX motif. This lipid modification appears essential for both localization and function within the MAPK pathway. Moreover, there is a second conserved cysteine residue upstream the Rho2 CAAX motif which might be palmitoylated in vivo like other Rho GTPases such as human RhoB. To investigate the role of palmitoylation in Rho2-signaling we constructed rho2Δ strains expressing the wild type, unpalmitoylated, or unprenylated versions of Rho2 as well as Rho2 chimeras fused to the carboxyl end from the essential GTPase Rho1, and we study their location and Rho2-dependent signalling within the CIP. Our results showed that in fission yeast Rho2 becomes palmitoylated in vivo and this modification is required for plasma membrane localization and proper signaling to the CIP. Pmk1 is constitutively localized in both cytoplasm and nucleus, as well as in the mitotic spindle and septum during cytokinesis. However, contrary to the current model for ERK1/2, its localization pattern appears unaffected by its activation status. In this context, we questioned the biological significance of nuclear localization of MAPK Pmk1. We have addressed this issue by characterization of mutants expressing Pmk1 versions excluded from the cell nucleus and anchored to the plasma membrane in different genetic backgrounds. We have found that nuclear localization of Pmk1 is not critical to exert their biological functions, although its presence in the nucleus is necessary for transcriptional regulation under cell wall stress. These evidences highlight the relevance of the spatial/temporal activity control of MAPK activity in eukaryotes.
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Redondo, i. Arolas Mar. "Llegat i vigència de les aportacions de l'exposició "The Family of Man" en la representació fotogràfica de la identitat." Doctoral thesis, Universitat de Barcelona, 2010. http://hdl.handle.net/10803/32049.
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La recerca que es presenta aborda la capacitat discursiva de la fotografia, delimitant uns usos concrets del mitjà fotogràfic i analitzant algunes exposicions que es qüestionen la fotografia que parla de l’home en relació amb el seu context social. És per aquest motiu que la investigació pren com a centre d’interès "The Family of Man", exposició fotogràfica de gran rellevància quant a la idea de projecte, quant al procés de gestió de les imatges, i quant a la recepció pública. Comissariada per Edward Steichen, es va inaugurar al Museu d'Art Modern de Nova York l’any 1955. Del seu estudi se’n conclou que es tracta d’un cas paradigmàtic de model expositiu fotogràfic que aglutinava molts dels aspectes que s’han debatut i es debaten encara al voltant de la fotografia, de l’art, i de llurs implicacions socials. En la recerca es circumscriuen els temes de reflexió més rellevants i s’observa com es presenten aquests en algunes exposicions o actituds artístiques de finals del segle XX, principis del XXI, les actituds reflexives i crítiques dels autors de les quals semblen revelar directament o indirecta, l’herència dels propòsits del fotògraf E. Steichen, artífex representatiu d’un corrent en la producció fotogràfica que procura conciliar l’art i la vida comuna. La revisió i l’anàlisi d’exhibicions perfilen el què ha canviat en la fotografia pel que fa a la percepció i representació de l’home i les seves relacions socials, i com aquests canvis s’han emmirallat en les diverses manifestacions artístiques contemporànies sobre l’home. Així mateix, el recorregut per les obres i el temps deixen paleses algunes de les modificacions que des dels anys cinquanta han esdevingut respecte a la concepció i comprensió de la imatge fotogràfica en el context de l’art.This research address the discursive capacity of photography, delimiting specific uses of the photographic medium and analyzing some exhibitions that question the photography that speaks about mankind in relation to its social context. It is for this reason that research takes as its focus of interest The Family of Man photographic exhibition of great relevance attending to the idea of the project, the management of the pictures, and in terms of public reception. Curated by Edward Steichen, was opened at the Museum of Modern Art in New York in 1955. Its study concludes that it is a paradigmatic case of model photography exhibition that brings together many of the issues being and discussed even now around the photography, art, and their social implications. The research reflects the highlights that are shown in some exhibitions and in several artistic attitudes of the late twentieth and twenty-first centuries, and also the critical and reflective attitudes of the authors which seem to reveal directly or indirectly, the inheritance of the purposes of the photographer E. Steichen, the most representative artifex of a photographic movement that tries to reconcile art and common daily life. The review and the analysis of exhibitions outline what has changed in the photography attending to the perception and representation of men and their social relationships, and how these changes have been mirrored in several contemporary art demonstrations about mankind. Likewise studying the works through the time reveals some of the changes that have occurred since the fifties about the conception and understanding of the photographic image in the context of art.
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Hörtin, Matilda, and Niki Karimgholipour. "Man tar plats : en kvalitativ studie om könsskillnader i chefers uppfattningar om karriärmöjligheter." Thesis, Stockholms universitet, Sociologiska institutionen, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-125676.
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Denna uppsats är en induktiv kvalitativ studie som avser att undersöka och belysa eventuella skillnader mellan kvinnliga och manliga chefers uppfattningar om karriärmöjligheter ur ett genusperspektiv. Metoden är semi-strukturerade intervjuer med sex chefer på två olika nivåer från tre olika avdelningar på ett statligt ägt företag. Datamaterialet behandlas med en kvalitativ innehållsanalys och tre olika teman lyfts fram som fokusområden, där materialet återkopplas till tidigare forskning, begrepp och teori: uppfattningar om attityder och stöd från företaget, uppfattningar om strukturella faktorer, samt uppfattningar om kombinationen av familj och karriär. Resultatet tyder på att individuella skillnader är mer framträdande än könsskillnader, men det går att se tendenser till könsskillnader inom våra fokusområden: (1) att de kvinnliga cheferna tenderar att vara mindre nöjda med sina karriärmöjligheter samt verkar uppleva ett lägre stöd från företaget än de manliga cheferna, (2) att varken de kvinnliga eller manliga cheferna anser att det finns negativa attityder eller könsstrukturer på arbetsplatsen mot ett specifikt kön, men att det dock finns en indikation på att de manliga cheferna kan gynnas av att vara i minoritetsposition, och (3) att de kvinnliga cheferna verkar ha en större ansvarskänsla för och påverkas mer av familjen i sina karriärer än de manliga cheferna. Det diskuteras dock att det är svårt att avgöra om skillnaderna beror på faktiskt upplevda skillnader eller om de har sin grund i genusskillnader i form av beteenden, uppfattningar och värderingar.
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Janze, Anna. "Förberedelse för att vårda en partner under pågående palliativ vård. : "...mycket är att man inte vet"." Thesis, Ersta Sköndal högskola, Institutionen för vårdvetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:esh:diva-2628.
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Bakgrund: Att vårda en närstående med livshotande sjukdom innebär ett stort ansvar och uppgiften kan både upplevas svår och tung men kan även vara en källa till tillfredställelse då man kan göra något för sin närstående. Flera studier har visat att situationen kan vara förknippad med negativa konsekvenser för närståendevårdaren. Förberedelse för att vårda är en faktor som visat sig ha samband med mer positiva konsekvenser av att vårda. Syfte: Att beskriva närståendes erfarenhet utifrån berättelser om förberedelse för att vårda sin partner i hemmet under pågående palliativ vård Metod: Kvalitativ intervjustudie, kvalitativ innehållsanalys. Deskriptiv design. Resultat: Analysen utmynnade i ett övergripande tema, Förberedelse i medvetenhet om döden och två teman; Strävan efter något att förhålla sig till i förberedelsen för det värsta; Förberedelse för att vårda en partner i livets slut- en utmaning ett ansvar och en möjlighet. Diskussion: Förberedelse för att vårda en partner i livets slut tolkades som en transition med betydelsen förberedelse i medvetenhet om döden. Två sätt att förhålla sig till döden och framtiden fanns; att skjuta upp förberedelsen eller att förbereda sig. De närstående förberedde sig trots ovisshet genom strävan efter något att förhålla sig till. Förberedelse för att vårda beskrevs som ett ansvar, en utmaning och en möjlighet. Det upptäcktes efter hand vad vårdarrollen och den förändrade relationen skulle innebära. Detta kunde upplevas antingen positivt eller negativt.Background: Caring for a family member with a life limiting illness is a big responsibility and it can be experienced as difficult and as a burden but it can also be a source of satisfaction doing good for a loved one. Studies have shown that the situation can be associated with negative consequences for the caregiver. Preparedness is a factor that is associated with positive outcomes of caregiving such as higher levels of wellbeing, less anxiety and higher rewards of caregiving. Aim: To describe caregivers experiences from their stories about preparedness when caring for a partner during palliative care. Method: The study design was descriptive using qualitative in depths interviews and qualitative content analysis. Result: One overarching theme emerged which was Preparedness for caregiving in awareness of death, and two themes witch were Striving for something to relate to when preparing for the worst and Preparedness for caregiving-challenges, responsibilities and possibilities. Discussion: The event could be seen as a transition that caused a major change in the lives of the participants influencing meaning, roles and actions. The overarching theme Preparedness for caregiving in awareness of death could be seen as the meaning influencing the transition and a change in values and priorities in the lives of the participants and in different ways of dealing with the situation. Nurses have an important role and may through a person centered approach understand and increase preparedness through knowing what the transition means for the caregiver and where in the process he or she is.
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Johnsson, Hilda. "Man vill ju veta vad som finns där ute... : En studie om unga människors val inför framtiden." Thesis, Linköpings universitet, Institutionen för kultur och kommunikation, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-94250.
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I denna uppsats har jag valt att skriva om unga kvinnors tankar kring karriär, familjeliv och identitet. Dessa ämnen är saker som jag tror att de flesta upplever eller har upplevt att det finns många tankar och frågor kring, och jag vill genom min studie ge dessa kvinnors bild av hur man får livspusslet att gå ihop och hur tankar kring identitet, karriär och familjeliv kring detta kan se ut. Jag kommer att skriva om detta utifrån två synsätt, dels från det individuella planet, där jag utgår från mina intervjuer och berättar om mina informanters tankar, dels ur ett bredare perspektiv där jag sätter informanternas berättelser i ett större samanhang, men fokus på unga människors situation i Sverige.In this paper, I have chosen to write about young women's thoughts on career, family life and identity. These substances are things that I think most people are experiencing or have experienced that there are many thoughts and questions about, and I want through my study give these women's view of how to get the puzzle of life go together and how ideas about identity, career and family around this might look like. I will write about this from two points of view, and from the individual level, where I use my interviews to talk about my informant thoughts, and from a broader perspective where I put narratives in a wider context, but the focus is on young people's situation in Sweden.
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Eklund, Rimsten Anders, and Mats Larsson. ""Det ger sig självt om man är en bra terapeut". En intervjustudie av hemuppgifter i familjeterapi." Thesis, Linköpings universitet, Avdelningen för kliniska vetenskaper, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-114905.
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Hemuppgiften är ett viktigt moment inom såväl Funktionell familjeterapi (FFT) som Dialektisk beteendeterapi (DBT). Målsättningen med denna uppsats var att utröna om, och i sådana fall på vilket sätt, hemuppgifter ges inom den familjeterapeutiska kontext som utgör ramen för FFT. En hypotes vid arbetets ingång var att de interaktionistiska hemuppgifterna kommit att ersättas av de mer beteendeorienterade som ingår i DBT. De personer som utgjort underlag för undersökningen arbetar alla på en öppenvårdsmottagning inom Barn- och ungdomspsykiatrin (BUP) i Uppsala, med antingen ovan nämnda Funktionella familjeterapi (n=3) eller med Dialektisk beteendeterapi (n=2). Syftet med studien var att, dels via en enkätundersökning dels via en intervju i fokusgruppform, försöka förstå mer av det psykoterapeutiska redskap som utgörs av hemuppgiften. Fokus låg på den relationella hemuppgift som familjeterapeuterna tillhörande nämnda team förväntas konstruera utifrån tillhandahållen FFT-manual. Resultatet visade på en relativt stor bredd när det gällde terapeuternas syn på och tillämpning av hemuppgiften, men det generella mönstret pekade på att terapeuterna i sitt praktiska arbete konstruerade såväl relationella som beteendeorienterade hemuppgifter. Vad som framkom är dock ett behov av och en önskan från familjeterapeuternas sida om en större tydlighet kring hur man går tillväga då man fastställer och ger en familj en relationellt orienterad hemuppgift. Det vi sluter oss till i vår uppsats är att ett sådant förtydligande inte låter sig göras med mindre än att man går till botten med och definierar vad funktionen av relationen innebär samt hur man använder sig av denna vid det som inom Funktionell familjeterapi kallas för relationsbedömningen.The homework is an important part of both Functional Family Therapy (FFT) and Dialectical Behavior Therapy (DBT). The goal of this essay has been to determine if, and in what way, homework is used in the context of family therapy, that is the frame of FFT. One hypothesis at the beginning of this work was that the interactional home assignments have started to be replaced by the behavior oriented ones that are a part of DBT. The individuals participating in the study are all working in a psychiatric outpatient clinic (BUP) in Uppsala. They are all using either Functional Family Therapy (n=3) or Dialectical Behavior Therapy (n=2) as treatment methods. The purpose of the study has been to try to understand more of the homework as a therapeutic instrument, especially the relational homework that family therapists are expected to work out on the basis of a manual that is provided within FFT. Two methods have been used to examine this: a survey and focus group interview. The results show a relatively large width when it comes to the therapists view on and practice of homework, though the general pattern indicates that they work out both relational as well as behavior oriented assignments in their practical work. However, there is a need and a wish of the family therapists to gain more clarity on how to determine and give a family a relational oriented homework. The conclusion of this essay is that a clarification like that is not possible, unless you go to the bottom with and define what the relational function is and how to use it in what within Functional Family Therapy is called the Relational Assessment Phase.
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Johansson, Lovisa, and Sabina Stenborg. "..." Det är konstigt att man tvistar om barn som man tvistar om inventarier i hemmet" : En studie om socialsekreterarens syn på barns delaktighet i umgängesärenden." Thesis, Karlstads universitet, Fakulteten för humaniora och samhällsvetenskap (from 2013), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-85676.
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Syftet med denna studie var att undersöka hur socialsekreterare beaktar barnperspektivet i umgängesärenden och vad som är avgörande när socialsekreteraren skall bedöma barnets åsikt. Barnperspektivet inriktades på barns delaktighet. Utgångspunkten för studien var fyra teorier, barndomssociologi, Harts delaktighetsstege, makt och ålderskategorisering samt blivande och varande. Studien genomfördes genom att använda en kvalitativ metod där fyra yrkesverksamma socialsekreterare inom familjerätt intervjuades. Resultatet visade att socialsekreterarna som deltog beaktade ett barnperspektiv på så sätt att de arbetar för och reflekterar aktivt kring att barn ska göras delaktiga i umgängesärenden. De ansåg även att det är viktigt att barnen får möjligheten till delaktighet. Det framkom även att det finns många faktorer som socialsekreterarna anser påverkar barns möjlighet till delaktighet i dessa ärenden och att det är ett komplext ämne. De faktorer som framkommer av resultatet var ålder, mognad, lojalitetskonflikter, föräldrarnas samtycke, relationen mellan socialsekreterare och barn samt riskområden. Slutligen framkom flera förslag på förbättring som kan göras för att barn ska bli ännu mer delaktiga än vad de är idag och att mycket av ansvaret ligger på de vuxna att detta händer.The purpose of this study was to investigate how social workers consider the child´s perspective in contact orders and what is crucial when social workers was to assess children’s opinions. The child´s perspective focused on children's participation. The starting point for the study was based on four theories: childhood sociology, Hart's participation ladder, power and age categorization and being or becoming. The study was carried out using a qualitative method where four professional social workers in family law were interviewed. The results showed that the social workers who participated considered the child's perspective in that they work for and actively reflect on the involvement of children in contact orders. They believe that it is important that the children get the opportunity to participate. Social workers believe that there are many factors affecting children’s ability to participate in contact orders, therefore making the subject complex/a complex matter. The factors that emerged from the result were age, maturity, loyalty conflicts, parental consent, the relationship between social workers and children and risk areas. Finally, several suggestions for improvement were discovered that could be utilized to make children even more involved in contact orders than they are today, and that much of that responsibility should lie with the adults.
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Biella, Andrea Alexandra do Amaral Silva e. "Famílias no museu de arte: lazer e conhecimento: um estudo sobre o programa educativo Interar-te do MAC USP." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/48/48134/tde-29052012-135440/.
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A pesquisa Famílias no museu de arte: lazer e conhecimento um estudo sobre o programa educativo Interar-te do MAC USP teve como objetivo investigar as motivações dos adultos que optam por proporcionar a crianças e jovens, nos momentos de lazer de sua família, atividades de cunho cultural e educativo e, com isso, observar os desdobramentos destas iniciativas na formação e na criação do hábito de frequentação de museus de arte de todos os envolvidos. Foi selecionado para estudo de caso o programa Interar-te do Museu de Arte Contemporânea da Universidade de São Paulo. Este programa uma das ações de extensão universitária da Divisão Técnico-Científica de Educação e Arte do MAC USP tem como público-alvo famílias e é realizado aos sábados, uma vez ao mês, entre janeiro e novembro; foi criado a partir de uma demanda institucional para a sede do Museu no Parque Ibirapuera, que é muito frequentado aos finais de semana pelas opções de lazer que oferece. Para compreensão do contexto da pesquisa, foram delimitados os conceitos de lazer e de família e abordados princípios sobre educação em museus de arte. Utilizou-se metodologias de análise qualitativa de pesquisa e outras informações complementares foram obtidas através de instrumentos quantitativos direcionados à amostra selecionada para estudo. Constatou-se que há influências da família de origem sobre os adultos na criação de seus hábitos de frequentação de programações artístico-culturais, assim como destes sobre suas próprias famílias, considerando-se a delimitação do perfil que a amostra representa; e, ainda, que o programa educativo Interar-te do MAC USP promove ensino e aprendizagem em artes visuais a diferentes faixas etárias e promove integração entre os membros das famílias que o frequentam.The research Families in the museum of art: leisure and knowledge a study about the Interar-te Educational Program from MAC USP aims to investigate the motivation of adults who provide their children with cultural and educational activities during their families leisure time, in order to observe the impact of these initiatives on the habit of attending museums of art among these family members. A program called Interar-te, which is developed by the Museum of Contemporary Art of the University of São Paulo (MAC USP), was chosen for this case study. This Program, whose target audience is directed to parents and their children, is held once a month, on Saturdays, between January and November, and is one of the university extension activities provided by the Technical-Scientific Division of Education and Art of MAC USP. It was created to supply an institutional demand of the Museums headquarters, located at Ibirapuera Park, which is a park that receives lots of visitors on weekends because of the leisure options it offers. The concepts of leisure and family were approached, and the principles related to education in art museums were approached in order to provide a better comprehension of the research context. The research was based on methodologies for qualitative research analysis, and other complementary information was collected by using quantitative tools, which were directed to the sample selected for the study. Considering the delimitation of the sample profile, we verified that families play an influential role on adults in relation to the construction of their habits of attending cultural-artistic programs, and that these habits also influence their own families. We also concluded that the Interar-te Educational Program of MAC USP promotes teaching and learning concerning visual arts for people of different ages and promotes integration among the family members who visit the Museum.
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Kufskie, Kathy L. "Family functioning and parental divorce as predictors of attachment styles and sexual attitudes in college students." Diss., St. Louis, Mo. : University of Missouri--St. Louis, 2009. http://etd.umsl.edu/r4602.
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Engström, Maja. "Familj eller karriär i arbetslivet, måste man välja? : -en uppsats om arbetstagares skydd mot diskriminering i arbetslivet." Thesis, Linnéuniversitetet, Institutionen för ekonomistyrning och logistik (ELO), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-33455.
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Pregnant workers are considered at risk in the labor market and therefore need extra protection from employment discrimination . The purpose of this essay is to investigate what protection of pregnant workers against discrimination in employment situations and if there is no corresponding protection for female workers claim the right to parental leave. The essay describes the national and EU rules on applications and practice, showing how pregnant women and workers on parental leave are treated in the labor market. Through Sweden's accession to the EU , we must apply the requirements nationally EU imposes on its member countries. The essay shows that pregnant employees have a strong legal protection from discrimination in employment , from both DL and by EU directives . Employers who deny workers employment because of pregnancy is guilty of direct discrimination on grounds of sex, because it is only women who may become pregnant. It is not important whether it is a temporary or permanent position . Employers must never deviate from the protection of pregnant workers in employment situations. Furthermore, states the essay that male workers are protected from unfair treatment in relation to parental leave by 16 § föräldraledighetslagen. Male workers are not as strongly protected as an employer is allowed to derogate from disadvantaged prohibition in certain situations.Gravida arbetstagare anses vara en riskgrupp på arbetsmarknaden och behöver därförextra skydd mot diskriminering i arbetslivet. Syftet med denna uppsats är att utreda vilket skydd gravida arbetstagare har mot diskriminering i anställningssituationer samt om det finns något motsvarande skydd för manliga arbetstagare gällande rätten tillföräldraledighet.Uppsatsen redovisar nationella och EU-‐rättsliga bestämmelser på området samt praxis som visar hur gravida och föräldralediga arbetstagare behandlas på arbetsmarknaden. Genom Sveriges anslutning till EU måste vi nationellt tillämpa de krav EU ställer på sinamedlemsländer.Uppsatsen visar att gravida arbetstagare har ett starkt rättsligt skydd från diskriminering i arbetslivet, både från DL samt genom direktiv från EU. Arbetsgivare som nekar arbetstagare anställning på grund graviditet gör sig skyldig till direkt diskriminering på grund av kön, eftersom det endast är kvinnor som kan bli gravida. Det är inte av betydelse om det gäller en tidsbegränsad -‐eller tillsvidareanställning. Arbetsgivare får aldrig frångå skyddet gravida arbetstagare har i anställningssituationer. Vidare fastslår uppsatsen att manliga arbetstagare skyddas mot missgynnande i samband med föräldraledighet genom 16 § föräldraledighetslagen. Manliga arbetstagare är dock inte lika starkt skyddad eftersom arbetsgivare tillåts att göra undantag frånmissgynnandeförbudet i vissa situationer.
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Randa, Carrie D. "Attributions, coping, self-blame and emotional status in victims of rape and domestic violence /." Electronic version (PDF), 2005. http://dl.uncw.edu/etd/2005/randac/carrieranda.html.
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Reis, Gilcelia Lima da Silva. "Homem-pai: do cenário da provisão material à construção do cuidado." Pontifícia Universidade Católica de São Paulo, 2016. https://tede2.pucsp.br/handle/handle/19345.
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Conselho Nacional de Desenvolvimento Científico e Tecnológico
This research aims to understand how men-fathers, in the family dynamics of contemporary Brazilian society, experience the exercise of the care of children. Thus, it seeks to discover, describe and analyze how the experiences of parental care have repercussions in the material life conditions: organization, routine and daily home actions, work and play with their children and evaluate motivations, problems, care consequences and loving relationship between parents and sons. The methodology is the qualitative approach to reality based on thematic oral history, from three men-parents with children that make part of the Musical Inclusion Program Guri Santa Marcelina (GSM). As a result, it is possible to say that, in Brazilian society, there are men with very different education, age groups and social levels, who choose to be part of parenting. The act of caring for children is a difficult, but pleasant task, not restricted to supplying basic material needs. In the view of respondent parents-men, care is the expression of love with commitment in all processes of human life
Esta pesquisa tem o objetivo de entender como os homens-pais, na dinâmica familiar da sociedade brasileira contemporânea, vivenciam o exercício do cuidado com os filhos. Assim, busca conhecer, descrever e analisar como as experiências do cuidado paterno vêm repercutindo nas condições materiais de vida: organização, rotina e ações cotidianas da casa, trabalho e lazer com seus filhos e avaliar motivações, dificuldades, consequências do cuidado e relação amorosa entre pais e filhos. A metodologia consiste na abordagem qualitativa da realidade com base na História Oral Temática, a partir de três homens-pais com filhos inseridos no Programa de Inclusão Musical Guri Santa Marcelina (GSM). Como resultados, é possível dizer que, na sociedade brasileira, surgem homens com escolaridade, faixas etárias e níveis sociais bastante distintos, que optam por fazer parte da criação dos filhos. O ato de cuidar dos filhos é tarefa difícil, mas prazerosa e não se restringe a suprir necessidades básicas materiais. Na visão dos homens-pais entrevistados, o cuidado é expressão do amor com comprometimento em todos os processos da vida humana