Dissertations / Theses on the topic 'Familial breast cancer'
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Collins, N. "BRCA2 in familial and sporadic breast cancer." Thesis, Institute of Cancer Research (University Of London), 2000. http://publications.icr.ac.uk/10070/.
Full textMohammed, Shehla Nilofer. "Familial breast cancer : a clinicopathological and genetic study." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299826.
Full textLuo, Liping. "A genetic study on familial breast cancer predisposing genes /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-628-5184-5.
Full textAgenbag, Gloudi. "Molecular genetic analysis of familial breast cancer in South Africa." Thesis, Link to the online version, 2005. http://hdl.handle.net/10019/953.
Full textMacInnes, Emma G. E. "Psychosocial outcomes in women at increased familial breast cancer risk." Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/20859/.
Full textPharoah, Paul David Peter. "Familial and inherited breast cancer in the East Anglian population." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621725.
Full textKast, Karin, and Kerstin Rhiem. "Familial Breast Cancer: Targeted Therapy in Secondary and Tertiary Prevention." Karger, 2015. https://tud.qucosa.de/id/qucosa%3A71423.
Full textVaittinen, Pauli. "Risk characterization of familial cancer using the Swedish Family-Cancer database with a special reference to breast cancer /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-723-1/.
Full textRenwick, A. A. "Familial breast cancer : are BRCA1 and BRCA2 mutations present in Scotland?" Thesis, University of Aberdeen, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.593342.
Full textAntoniou, A. C. "Developing a comprehensive risk model for familial breast and ovarian cancer." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596129.
Full textMaguire, Paula. "Investigation of the genetic basis of familial non-BRCA1/2 breast cancer /." Stockholm, 2005. http://diss.kib.ki.se/2006/91-7140-602-6/.
Full textDe, Azevedo Moreira Reis Marta. "Evaluation of healthcare management issues in the provision of clinincal services for familial breast/ovarian cancer /." St Andrews, 2009. http://hdl.handle.net/10023/728.
Full textGiongo, Cíntia de Oliveira. "Caracterização imunogenética de variantes dos genes CCR2, CCR5 e HLA-G como potenciais alvos para diagnóstico, prognóstico e tratamento do câncer de mama feminino esporádico e familial." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/78137.
Full textBreast cancer is the most common cancer among women. Its etiology is complex, where genetic, environmental and endocrine factors contribute to tumor development. It is estimated that 5 to 10% of the breast cancers are represented by familial breast cancers and 90 to 95% are represented by sporadic breast cancers. Independent of the etiology, the major aggravating consequence is the ability of tumor cells to metastasize. Mutations can lead to a change or loss of expression a different genes and this allows the appearance of genetic and phenotypic features which contribute to tumor progression. Among these features is the ability of tumor cells to evade from the immune cells or even use immune cells in the promotion of a inflammatory microenvironment promotion which may help angiogenesis and, later, metastasis. The aim of our study was to evaluate four important polymorphic variants of genes which encode important immune system molecules, two related genes encoding chemokine receptors, CCR2 and CCR5, and two related to HLA-G gene in 188 women with breast cancer (105 women with familial breast cancer and 83 with sporadic breast cancer) and 151 women without cancer and family history of cancer (control group), such as potential markers for diagnosis and prognosis of breast cancer. CCR2 polymorphism, CCR264I, and one HLA-G polymorphism, +3142, were genotyped by PCR-RFLP. CCR5delta32 and 14pb HLA-G polymorphism were genotyped by PCR. Allelic, genotypic and haplotypic frequencies were estimated and compared between the groups using the Chi-square test or Fisher's exact test and subsequently were associated to diagnostic and prognostic factors. We observed a higher allelic frequency of the CCR2 wild type allele, Val (p = 0.040, OR 0.61, 95% CI = 0.38 - 0.98) e CCR5 wild type allele, Wt (p = 0.032, OR 0.46, CI 95% = 0.23 - 0.94) and higher haplotype frequency of the double wild type variants (Wt/Val) of these same genes (CCR2 and CCR5) in women in the control group (p = 0.030) compared to women with familial breast cancer. All polymorphisms were evaluated together with the clinical parameters and it was observed that women with breast cancer showed sporadic cancer latter (57.29 ± 8.457 years and 44.23 ± 12.092 years for women with sporadic breast cancer and familial breast cancer, respectively, p < 0.001) and more invasiveness (p = 0.001) as compared to women with familial breast cancer. Moreover, the HLA-G 14pb and CCR264I polymorphism, showed a positive association with tumor aggressiveness in women with sporadic breast cancer (p = 0.039 and p = 0.005, respectively). Our data suggest that invasive cancers may be associated with increased immune cells infiltration and inflammation in the tumor microenvironment mediated by both CCR2 receptor and HLA-G molecule.
Lloyd, Susannah. "Understanding the experience of prophylactic bilateral mastectomy : a grounded theory study." Thesis, University of East Anglia, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302194.
Full textCatucci, Irene. "Identification of low-penetrance alleles, genetic modifiers and mutation analysis in familial breast cancer cases." Thesis, Open University, 2013. http://oro.open.ac.uk/54681/.
Full textBubien, Virginie. "Identification de nouveaux gènes de prédisposition héréditaire au cancer du sein par génotypage tumoral et séquençage de nouvelle génération." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0393/document.
Full textHereditary breast cancers (BCs) account for 5-10% of all diagnosed BCs, yet only 50% of such tumors arise in the context of a germline mutation in known tumor suppressor genes such as BRCA1 or BRCA2. The vast genetic heterogeneity which characterizes BRCAx families makes grouped studies impossible to perform. Next generation sequencing (NGS) techniques, however, allow individual families to be studied in order to identify private mutations. Single nucleotide polymorphism (SNP) arrays allow the detection of conserved haplotypes within recurrent regions of loss of heterozygosity, common to several familial tumors, therefore identifying genomic loci likely to harbor a germline mutation in cancer predisposition genes. The combination of both exome sequencing and SNP arrays for a series of 17 familial BC did not allow the identification of a novel BC predisposition gene, but revealed a germline ATM mutation associated with a loss of the wild-type allele in a BRCAx family. The analysis of 17 additional breast tumors from ten BC families in which a germline ATM mutation had been identified revealed a high frequency of wild-type allele loss in these tumors (>80% compared to the 20% expected in sporadic BC; p <0.001). This result argues strongly in favor of the involvement of ATM in the carcinogenesis of these tumors as a tumor suppressor gene and suggests that germline ATM mutations are involved in a subset of familial BC
Elliott, Diana. "The impact of genetic counselling for familial breast cancer on women's psychological distress, risk perception and understanding of BRCA testing." University of Western Australia. School of Population Health, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0190.
Full textde, Azevedo Moreira Reis Marta. "Evaluation of healthcare management issues in the provision of clinical services for familial breast/ovarian cancer." Thesis, University of St Andrews, 2009. http://hdl.handle.net/10023/728.
Full textErkko, H. (Hannele). "TOPBP1, CLSPN and PALB2 genes in familial breast cancer susceptibility." Doctoral thesis, University of Oulu, 2008. http://urn.fi/urn:isbn:9789514289682.
Full textZheng, Guoqiao [Verfasser], and Kari [Akademischer Betreuer] Hemminki. "Breast and ovarian cancers in women: familial clustering, second primary cancer and cause of death / Guoqiao Zheng ; Betreuer: Kari Hemminki." Heidelberg : Universitätsbibliothek Heidelberg, 2019. http://d-nb.info/1195710216/34.
Full textKamon, Phochana Pimpicha Patmasiriwat. "Variant analysis at 5' and 3' untranslated regions of BRCA2 in thai familial breast and ovarian cancer /." Abstract, 2004. http://mulinet3.li.mahidol.ac.th/thesis/2547/cd364/4436684.pdf.
Full textKarppinen, S. M. (Sanna-Maria). "The role of BACH1, BARD1 and TOPBP1 genes in familial breast cancer." Doctoral thesis, University of Oulu, 2009. http://urn.fi/urn:isbn:9789514291593.
Full textCoignard, Juliette. "Nouvelles stratégies pour l’étude des facteurs génétiques impliqués dans le cancer du sein familial." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS426.
Full textOne of the most important risk factors for breast cancer (BC) is having a family history of BC. Around 20% of the familial BC risk is explained by rare mutations in the genes BRCA1 and BRCA2 (BRCA1/2). An additional 30% of the risk is accounted for mutations in other known genes, like ATM or TP53, and by common genetic variants, called single nucleotide polymorphism (SNPs), identified in population-based GWAS. Therefore, the majority of the familial forms of BC remains unexplained. Furthermore, there are large variations in the estimation of the BC lifetime risk for BRCA1/2 mutation carriers. It has been shown that some SNPs identified in the general population by GWAS (Genome Wide Association Studies) modified BC risk for BRCA1/2 mutation carriers. Therefore, little is known on how these SNPs interact with BRCA1/2 mutations since association studies have been performed within the population of BRCA1/2 mutation carriers so far.In the first part of this PhD project, I developed a novel strategy to analyze genetic factors by integrating simultaneously environmental and lifestyle factors. This strategy was used to analyze the data of GENESIS study composed of pairs of sisters affected by BC without BRCA1/2 mutation and controls from the general population. 5,000 BC cases and controls were genotyped for the 200,000 SNPs targeted by the iCOGS array. Groups of subjects was created according to their exposition profile reflecting expositions to radiation or reproductive factors. Analyses stratified on groups built according to their reproduction factors exposures did not highlighted specific variants. However, analyses stratified on groups reflecting the chest X—ray exposures showed potential specific SNPs for women who had never been exposed to chest X—ray, in genes XRCC4 and MAGI1, and for women highly exposed to X-ray exposures, in gene FGFR2, already known in the general population.The second aim was to identify and characterize genetic modifiers of BC risk for BRCA1/2 mutation carriers using data from the international consortia CIMBA (Consortium of Investigators of Modifiers of BRCA1/2) and BCAC (Breast Cancer Association Consortium). I developed a case-only GWAS analysis where we compare genotype frequencies between 60,212 unselected BC cases from the BCAC and 13,007 BC cases from CIMBA. We identified 4 novel variants associated with BC for BRCA1 mutation carriers and 4 for BRCA2 mutation carriers at P<10-8. MADD, SPI1 and EIF1 genes, already associated with BC biology, was predicted by the tool INQUISIT, to be target genes of the potential causal variants located in the locus 11p11.2 associated with BRCA1 status.These new SNPs could be used to improve polygenic risk scores (PRS). Studies considering the exposure profile should be implemented in larger population. The models could then evolve towards an adaptation of the PRS according to women’s exposure profiles and that throughout their life
Gold, Stefan M. "Acute endocrine stress reactivity and recovery in women at familial risk of breast cancer association with perceived stress and depressive symptoms /." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968355358.
Full textKechik, Joy E. "Comparing Family Sharing Behaviors in BRCA Carriers with PALB2 Carriers." Scholar Commons, 2019. https://scholarcommons.usf.edu/etd/7825.
Full textDomaison, Sophie. "Étude longitudinale du fonctionnement des familles confrontées au cancer de la mère." Thesis, Toulouse 2, 2012. http://www.theses.fr/2012TOU20135.
Full textAny serious illness occurring in a patient threatens and alters the balance of their family group. The objective of this study is to identify the impact of breast cancer on a mother's nuclear family, when young children are present, with the longitudinal assessment of family functioning, psychological distress and adaptation strategies, through the perspective of different members of the group: the sick mother, the father and child(ren).Method: 39 parents (23 mothers and 16 fathers) of children aged between 6 and 12 completed self-assessment questionnaires as well as 22 children participated in research interviews at four evaluation times: the first (T1), the third (T2) and fifth (T3) of the mother’s chemotherapy, and two months after the end of chemotherapy (T4).Results: Family functioning as perceived by the family’s members is typical and stable over time. Spouses perceive more difficulties within the family than the patients and the children. The temporal evolution of variables highlights the T3 as a respite for the nuclear family. Levels of psychological distress are not pathological, but are different depending on the member’s place in the family. Women are more distressed than their spouses and children, and have more use of coping strategies focused on problem solving and seeking social support. The level of depression, hostility and the use of coping strategies focused on emotion in mothers explain their perception of family functioning. By contrast, the psychological state and the mode of adaptation of spouses and children do not affect their perception of family functioning.Conclusion: These results show the importance of combining qualitative and quantitative longitudinal methodology to analyse the views of all members of the family and improve the understanding of their experiences with the disease of the mother
Vehmanen, Paula. "Breast cancer-predisposing genes in Finnish breast and ovarian cancer families." Helsinki : University of Helsinki, 2001. http://ethesis.helsinki.fi/julkaisut/mat/bioti/vk/vehmanen/.
Full textBailey, A. Kathleen (Ann Kathleen). "Interactional Patterns in Families of Patients with Breast Cancer." Thesis, North Texas State University, 1985. https://digital.library.unt.edu/ark:/67531/metadc330997/.
Full textFord, Deborah. "Genetic epidemiology of breast and ovarian cancer." Thesis, Institute of Cancer Research (University Of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367527.
Full textDavis, Sarah Harmon. "Does Family Communication Matter? Exploring Knowledge of Breast Cancer Genetics in Cancer Families." BYU ScholarsArchive, 2018. https://scholarsarchive.byu.edu/etd/7246.
Full textToviessi, Paula. "The family health decision-making model family influence on breast cancer screening adherence /." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1180551704.
Full textYong, JinSun. "Factors influencing family functioning in families with breast cancer in the mother /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/7367.
Full textSimpson, Margaret Anne. "Family beliefs of women with breast cancer in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31245900.
Full textIzatt, Louise Patricia. "Ataxia telangiectasia : mutation detection in ataxia telangiectasia families and early-onset breast cancer cases." Thesis, King's College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343596.
Full textMentoor, J. L. D. (Juliet Lewie Dionee). "Identification of rare gene variants in South African breast cancer families through next generation sequencing." Thesis, University of Pretoria, 2017. http://hdl.handle.net/2263/63043.
Full textThesis (PhD)--University of Pretoria, 2017.
Genetics
PhD
Unrestricted
Biffi, Raquel Gabrielli. ""A dinâmica familiar de um grupo de mulheres com câncer de mama"." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/22/22133/tde-11042005-152406/.
Full textThe diagnosis of cancer, in general, and of breast cancer in particular has the potential to cause a psychosocial instability not only in the person with the disease, but also in the family context. Therefore, the author aimed at identifying the perceptions of family members about the family dynamics after breast cancer, as well as the differences regarding: family composition, gender, age, literacy level and occupation. This was an exploratory and descriptive research with 23 family members of 10 families of women with breast cancer. In order to collect data, the author used individual interviews that were recorded and transcribed. Data were analyzed through content analysis, aiming at identifying the thematic units related to the family dynamics as described by Barnhill. The results revealed that the family members, independently of their age, literacy level and occupation, showed positive aspects of the family dynamics. Regarding the feminine gender, this in the view of husband and children was placed in an important position in the reorganization of the family unit. The findings showed that the breast cancer in a family member causes alterations in the family dynamics and, on the other hand, the families use the potentials of each member, in particular, in the search for family stability.
Schuler, Tammy A. "Marital Quality Affects Biobehavioral Outcomes in Advanced and Recurrent Breast Cancer Patients." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306854906.
Full textGinter, Amanda Christine. "The Consequences of Mothers' Breast Cancer Experiences for Their Adult Daughters' Intimate Relationship Decisions: A Phenomenological Approach." Oxford, Ohio : Miami University, 2010. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=miami1271940770.
Full textSantana, dos santos Elizabeth. "Contribution of the Missense and Non-Coding BRCA1/2 Variants for the Hereditary Predisposition and Response to Treatment of Breast and Ovarian Cancers Assessment of the Functional Impact of Germline BRCA1/2 Variants Located in Non- Coding Regions in Families with Breast and/or Ovarian Cancer Predisposition Non-Coding Variants in BRCA1 and BRCA2 Genes: Potential Impact on Breast and Ovarian Cancer Predisposition." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASS027.
Full textOvarian and breast cancers are currently defined by the main pathways involved in the tumorigenesis. In hereditary breast/ovarian cancers (HBOC), tumors with BRCA1/2 pathogenic variants (PV) present an impairment of DNA repair by homologous recombination (HR). For many years, BRCA1/2 PV were only searched on germline DNA. Currently, this information is also searched at tumor level to personalize treatment. Even so, the reason of the inactivation of this pathway remains uncertain for most cases, even in the presence of HR deficient signature.Gathered evidence indicates that protein inactivating PV may not be the only mechanism of HR dysfunction. In this context, the main objective of this thesis is to identify alternative mechanisms of HR inactivation to improve both: genetic counseling and therapeutic response. For this purpose, we have attempted to contribute to non-coding and missense (other than premature stop codon) BRCA1/2 variant classification and searched for new biomarkers of therapeutic response to DNA damage agents in other HR genes.We identified germline variants in key transcriptional regulatory elements of BRCA1 and BRCA2, and demonstrated that part of them were functionally active and had additional arguments suggesting pathogenicity. We also explored molecular features of breast and ovarian tumors from BRCA1 variant carriers and observed a predominance of loss of the wild-type allele. Conforming to this evidence, we propose to incorporate LOH information, into the multifactorial model for BRCA1 variant classification. Finally, besides the enrichment of BRCA1/2 germline and somatic PV, we described alternative mechanisms of HR inactivation in a OC population presenting optimal response to platinum-based chemotherapy, including BRCA1 promoter hypermethylation and also mutations in other genes of HR pathway
Rouault, Audrey. "Etude génomique des cancers du sein familiaux liés à une mutation constitutionnelle du gène BRCA2." Thesis, Bordeaux 2, 2013. http://www.theses.fr/2013BOR22122/document.
Full textGermline BRCA1 and BRCA2 mutations account for 20-30% of familial breast cancer. The main indication for BRCA2 screening is a family history, but the mutation detection rate in patients selected this way is low. The identification of characteristics common to BRCA2-associated tumors would improve the criteria used to select patients for BRCA2 screening and could identify factors implicated in BRCA2-mutant breast cancer tumorigenesis. The analysis of BRCA2-mutant breast tumor genomic profiles identified deletions of chromosomes 13q and 14q as a common feature of BRCA2-tumors. Supervised gene expression analysis of BRCA2-mutant breast tumors and familial breast tumors without germline BRCA1 or BRCA2 mutations identified a specific BRCA2 gene signature. Exome sequencing of chromosomes 13q and 14q for 5 BRCA2-mutant tumors, and their associated germline DNA was performed in order to identify the target(s) of the specific genomic deletions in the BRCA2 tumors. This analysis characterized somatic variants that will be screened for in a larger cohort of BRCA2 and control tumors cases to explore their role in BRCA2-mutant breast cancer. Our study identified deletions of chromosomes 13q and 14q as a common feature of tumors with germline BRCA2 mutations, as has been observed in several previous studies. We suggest that FISH analysis for the deletion of these chromosomes would be a rapid and technically feasible first step to select tumors worth screening for germline BRCA2 mutations and we hypothesize that the inactivation of candidate genes located in these deleted regions allows the cell to resume division and progress thus contributing to tumorigenesis in BRCA2-mutant tumors
Imada, Teresa Cristina Martins Leite. "Adaptação transcultural e validação da Family Dynamics Measure II (FDM II) para familiares de mulheres portadoras de câncer de mama no Brasil." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/22/22133/tde-03092008-115235/.
Full textBreast cancer is a disease that affects the woman\'s family and, the way the family faces the disease affects the woman coping process. Knowing the family dynamics and identifying interaction aspects among the relatives affected by the disease, and that may damage the coping process and life quality of the woman and her family, is an initial stage to develop adequate services for the focused population. The use of well constructed and reliable tools to assess the family dynamics is a relevant strategy. Tools of that kind, to achieve such results, were not available in Brazil. Therefore, the cross-cultural adaptation and validation of a north-American instrument for family assessment was chosen to supply this need and became the purpose of this study. The chosen scale was the Family Dynamics Measure II (FDM II), a 66 items questionnaire, built by a group of nurses and based on Barnhill\'s healthy family system. The adaptation process involved the translation, back-translation, assessment of the equivalence between the original and the back-translated version by the main scale\'s author, a semantic analysis and two face and content validity assessments by judges. For the psychometric properties tests of the instrument, analysis of the construct were carried out by means of factor analysis and convergent validity towards Hospital Anxiety and Depression Scale (HADS); and reliability analysis, through items internal consistency calculation (Cronbach\'s alpha). The FDM II adapted version, HADS, and a socio-demographic identification form were submitted to a sample with 251 breast cancer women\'s relatives, in treatment at two health services facilities in Sao Paulo state. The product of the semantic and the face and content validity analysis resulted in a version of the FDM II in Portuguese adapted for use in Brazil. Factor analysis showed that the adapted version did not confirm the theoretical dimensionality. However, it was like to those obtained by the authors at the factor analysis on the original instrument. At the convergent validity analysis on FDM II and HADS, the correlation between anxiety and depression measurements and the FDM II dimensions measurements were inverted, from moderate to low intensity. At the reliability analysis, the items internal consistency were very good (α = 0,90), despite the low coefficients by dimension. The conclusion is that the FDM II adapted version was considered valid and new studies to strengthen this evidence are suggested.
Sánchez-Cid, Pérez Lourdes. "Análisis de los perfiles de expresión de microRNAs en cáncer de mama y de la implicación de la familia miR-200 en metástasis." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/402827.
Full textThe maintenance of an epithelial gene program is essential for the metastatic growth of epithelial cancers, including breast cancer. However, little is known of the molecular and cellular mechanisms leading to the enhanced proliferative and survival properties of metastatic epithelial cells. We report here that forced expression of miR-200s in MCF10CA1h mammary cells induced not only a strong epithelial program but also aldehyde dehydrogenase (ALDH) activity, mammosphere growth and ability to form branched tubuloalveolar structures while promoting orthotopic tumor growth and lung colonization in vivo. This was accompanied with the expression of luminal differentiation markers in vitro and in vivo, the overall phenotype being compatible with a promotion of luminal progenitor traits. Interestingly, the morphology of tumors formed in vivo by MCF10CA1h cells expressing miR-200s was reminiscent of metaplastic breast cancer (MBC) and the epithelial components of MBC samples expressed significantly higher levels of miR-200s than their mesenchymal components and displayed a marker profile compatible with luminal progenitor cells. Additionally, the miR-200 family showed enhanced expression along progression of invasive ductal breast cancer (IDC) from primary tumors to distant metastases, further reflected in higher blood levels of miR-200b in patients with regional or distant metastases relative to patients with primary node-negative tumors. We propose that the expression of epithelial gene programs through miR-200 family microRNAs promote traits of highly proliferative mammary luminal progenitor cells, thereby exacerbating the growth and metastatic properties of transformed mammary epithelial cells.
López, Nicolás Rubén. "Estudio de la función de la familia de Proteínas Quinasas C en el cáncer de mama." Doctoral thesis, Universidad de Murcia, 2011. http://hdl.handle.net/10803/28234.
Full textIn this Doctoral Thesis, the role of several fatty acids like arachidonic, docosahexaenoic, eicosapentaenoic and oleic, as well as some DAG-lactones derivatives, on the activation of different PKC isoforms has been studied. Some breast cancer cell lines, specifically BT-474, MCF-7 and MDA-MB-231, have been used as a model. The role of PKC in proliferation, invasion and migration has been studied by means of cellular and molecular techniques, confocal microscopy, siRNA and gene expression microarrays. The results obtained reveal new molecular mechanisms of PKCalpha; localization and activation in breast cancer cell lines. It is also interesting the anti-proliferative and pro-apoptosis role of several fatty acids tested, as well as the direct involvement of PKCalpha; in proliferation, migration and invasion of breast cancer cells
Clark, Cammi. "When Bad Genes Ruin a Perfectly Good Outlook: Psychological Implications of Hereditary Breast and Ovarian Cancer via Narrative Inquiry Methodology." Antioch University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=antioch1565254126257837.
Full textCrafford, Johannes Daniel. "Die groei van hoop na mastektomie 'n narratiewe, pastoraal-gesinsterapeutiese studie /." Thesis, Pretoria : [s.n.], 2003. http://upetd.up.ac.za/thesis/available/etd-06242004-110440/.
Full textFernandes, Simone Batista de Abreu. "Diagnóstico de um grupo de familiares em risco para o câncer de mama: contribuição para a assistência de enfermagem." Universidade do Estado do Rio de Janeiro, 2012. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=3733.
Full textDue to the incidence, mortality and high costs, female breast cancer is considered a Health Care issue in Brazil. Its etiology binds an interaction of various risk factors which can be environmental and genetic ones. A positive family history for breast cancer is an important risk factor for the development of this pathology. Knowing the factors and protection measures allow the women with high risk create personal strategies that minimize the damage caused by the disease. Objectives: evaluate the level of knowledge of the women regarding the risk of breast cancer development related to family history with population which carries this neoplasia assisted by the Hospital do Câncer III, Cancer National Institute (INCA) branch specialized on breast cancer treatment and control, located at the city of Rio de Janeiro, Brazil; describe the social demographical characters of the women whose relatives are breast cancer patients and report their hormonal and reproductive history as well as their health care habits. Methodology: It consists of an exploratory study under a quantitative perspective in a descriptive and transversal way with 52 women that accompanied their hospitalized relatives in a clinic and surgery unity of Hospital do Câncer III. The data collection was performed between July and August 2011. The sampling technique adopted was intentionally the non-probabilistic. The applied sample size calculation was infinite population. The selected variables to compose the study were the following: social demographical aspects, reproductive and hormonal life aspects, health care aspects and awareness concerning the pathology/disease. The structured interview counted with a form of 63 questions. Results: 61,5% were daughters 34,6% were sisters and 3,8% were mothers, 40,4% lived in the city of Rio de Janeiro, 86,4% were between 29 and 51 years old, 32% were yellow, 46,1% finished high school, 46,2% were housewives, 15,4% had premature menarche, 7,7 % had late menopause, 7,7% adopted Hormone Replacement Therapy (HRT), 38,5% never got pregnant 3,8% got pregnant after 30 years old, 3,8% did not breastfeed, 42,4% took hormonal contraceptive for more than 5 years and 40,4% never stopped taking hormone contraceptive or stopped for period under 6 months, 7,7% and 7,6% never stopped taking hormone contraceptive and had more than 24 months from their last gynecological exam. Regarding the degree of awareness 34% agreed with the risk factor affirmatives, 65% agreed with preventive measures and the health professionals were the main source of information about breast cancer. Conclusion: first-degree relative associated with lack of knowledge put the women more vulnerable in relation to general feminine population. Here resides the chance for nursery assistance educational strategies which achieve health promotion and contribute for a disease changing panorama caused by early detection.
Rieger, Michael A. "CYP4Z1 und CYP4Z2P: Identifizierung neuer Mitglieder der humanen Cytochrom P450 Familie mit präferentieller Expression in Brustdrüsengewebe und Mammakarzinom." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2004. http://nbn-resolving.de/urn:nbn:de:swb:14-1093525824984-91466.
Full textViale-Garrone, Audrey. "Période de la ménopause, état de santé orale et facteurs systémiques." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM5028/document.
Full textIn a cross-sectional study of 202 postmenopausal and premenopausal women,the objectives of this study are to demonstrate a link between menopause and altered state of oral health.To evaluate the action of HRT on dental disease and finally on the tooth mortality. To assess and clarify the relationship between oral health and various general diseases and links between psyche and soma in postmenopausal women.Also discussed was the influence of bisphosphonates on the state of periodontal health.Finally,it was decided to place the study links oral menopausal status in a social and anthropological perspective.It appears then that menopause results in an altered state of oral health,(p = 0.003).HRT has a beneficial effect on the periodontal disease.The biological effects of diabetes are related to dental mortality (p = 0.050). This study emphasize the influence "per se" a bad oral health status for coronary artery disease (OR = 1.214).In postmenopausal women, stressful events, dry mouth, joint and bone diseases, hormonal deficiency are factors variously related dental mortality during this period. Moreover, it was found that women who have recently been treated for breast cancer developed more dental caries (p = 0.031 OR = 2.161).The study related the effects of bisphosphonates on the alteration of periodontal (p = 0.011), despite taking HRT (p = 0.020).In addition,background socio-economic favored contribute to the medicalization of physiological phenomenon. The fact of living alone would affect the loss of dental organs (p = 0.035). Finally, the regular practice of a sport improve the state of oral health (p = 0.036)
Bosch, Gutiérrez Almudena. "Role of Ring1B in ephitelial to mesenchimal transition, invasion and migration of mammary epithelial cells." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7230.
Full textLas proteínas del grupo Polycomb (PcG) forman complejos modificadores de la cromatina esenciales en el desarrollo embrionario y en la renovación de las células madre, y su desregulación ha sido asociada al cáncer. Varios estudios muestran la posible implicación de las proteínas de PcG en la progresión tumoral y en la metástasis, pero a pesar de ello se sabe muy poco de los procesos moleculares en los que estas proteínas están participando. Por otro lado, los procesos moleculares responsables del peor pronóstico en cáncer, la metástasis, que continua siendo una enfermedad incurable, siguen sin estar completamente elucidados. En esta disertación mostramos el papel de Ring1B, una proteína del PcG, en tres procesos implicados en la metástasis: en la transición epitelio-mesénquima (EMT), un proceso morfogénico crítico en el desarrollo embrionario y durante la progresión de varios cánceres epiteliales, y en la migración y la invasión de las células epiteliales mamarias.
Lourenço, Rita Adubeiro. "Functional Characterization of Variants of Unknown Significance in Familial Breast Cancer." Master's thesis, 2018. http://hdl.handle.net/10362/56683.
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