Journal articles on the topic 'Falisci'
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1
Carlucci, Claudia, Maria Anna De Lucia Brolli, Simon Keay, Martin Millett, and Kristian Strutt. "An archaeological survey of the Faliscan settlement at Vignale, Falerii Veteres (province of Viterbo)." Papers of the British School at Rome 75 (November 2007): 39–121. http://dx.doi.org/10.1017/s0068246200003524.
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UNA RICOGNIZIONE ARCHEOLOGICA DELL'INSEDIAMENTO FALISCO A VIGNALE, FALERII VETERES (PROVINCIA DI VITERBO)L'articolo presenta i risultati di una ricognizione geofisica condotta a Vignale nel 2001–2 come parte del ‘Progetto città romane nella media e bassa valle del Tevere’. Il sito costituisce una parte importante dell'insediamento topograficamente complesso di Falerii Veteres (moderna Civita Castellana) nella provincia di Viterbo. Il sito ebbe una lunga e complessa occupazione che si estese dall'età del bronzo al basso medioevo, benché il suo principale periodo di vita sia stato l'età del ferro.Le caratteristiche di questo sito particolare necessitavano di una ricognizione topografica dettagliata, associata all'uso della magnetometria, della resistività e di un programma di campionatura geochimica. I risultati di simili approcci hanno gettato nuova luce sull'organizzazione spaziale del pianoro di Vignale. Inoltre, i dati sono stati integrati con quelli raccolti in passato sulla stessa Vignale da Raniero Mengarelli tra il 1895 e il gennaio del 1896. Le evidenze emerse, insieme al riesame delle terrecotte raccolte sul sito, suggeriscono che a Vignale si trovasse uno dei santuari falisci principali di Falerii Veteres e che esso si sia sviluppato tra il V e il III secolo a.C.
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Rigobianco, Luca. "Falisco." Palaeohispanica. Revista sobre lenguas y culturas de la Hispania Antigua, no. 20 (May 1, 2020): 299–333. http://dx.doi.org/10.36707/palaeohispanica.v0i20.373.
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L’articolo è dedicato al falisco, una varietà indoeuropea appartenente al filone italico e affine al latino attestata da circa 300 iscrizioni provenienti dall’agro falisco nel Lazio e datate dal VII al II secolo a.C. Nello specifico nella prima parte dell’articolo si offre un quadro di carattere generale relativo alla lingua e alla epigrafia falische aggiornato alla luce di una revisione della documentazione e degli studi sull’argomento. Nella seconda parte dell’articolo si prendono in considerazione taluni problemi e prospettive di carattere editoriale e linguistico con particolare attenzione rispettivamente alla iscrizione ‘di Cerere’ e alle iscrizioni capenati.
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Cristofani, Mauro. "Etruschi nell' Agro Falisco." Papers of the British School at Rome 56 (November 1988): 13–24. http://dx.doi.org/10.1017/s0068246200009545.
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ETRUSCANS IN THE AGER FALISCUSThe Etruscan inscriptions that have been found in the Ager Faliscus document differing historical trends. At Narce, the continuity of the epigraphic evidence between the seventh and third centuries B.C. demonstrates that a group of Etruscan-speakers lived there permanently; their language retained archaic characteristics and underwent phonological changes from contact with the Faliscan language. In the northern part of the Ager Faliscus, however, the distribution of upper class Etruscan names suggests that groups of Etruscans were integrated rapidly into the Faliscan population. These Etruscans probably came from the territory of Volsinii (Orvieto), forced to emigrate after the destruction of their city in 264 B.C.
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Joseph, Brian D., and Rex E. Wallace. "Is Faliscan a Local Latin Patois?" Diachronica 8, no. 2 (January 1, 1991): 159–86. http://dx.doi.org/10.1075/dia.8.2.02jos.
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SUMMARY Faliscan clearly shows affinities with Latin, but the exact nature of the relationship between the two languages has not met with complete acceptance. Some scholars treat Faliscan as nothing more than a 'rural dialect' of Latin, though the inexactness of the designation 'dialectal Latin' makes this characterization problematic.Moreover, it is demonstrated here that the various features that are claimed to link Faliscan and non-Roman Latin to the exclusion of the Latin of the city of Rome are all rather late in their appearance in Faliscan, while a few very early features are to be found that unite Faliscan with all of Latinity. At the same time, though, there are significant isoglosses separating Faliscan from all Latin dialects, Roman and non-Roman. The conclusion to be drawn is that Faliscan is a separate language from Latin and not a dialect of Latin, though it is closest sibling to Latin in the Italic family tree. RÉSUMÉ La question du rapport génétique entre le latin et le falisque est examinée ici à la lumière de la méthodologie comparative et au modèle dialectologique du 'Stammbaum'. Il est démontré que le falisque n'est pas un dialect rurale du latin, comme l'on a proposé encore tout récemment, à la base de trois faits: bien des characteristiques qui se retrouvent dans les deux langues n'apparaissent que très tard dans la tradition falisque; il y a aussi des vieilles innovations qui unifient les deux; et il y a des isoglosses qui séparent le falisque de tous les dialectes latins — ceux de Rome aussi bien que les autres. Le falisque est une langue liée au latin mais à la même fois il n'est pas equivalent à un vrais dialecte latin. ZUSAMMENFASSUNG In diesem Aufsatz wird das Verhaltnis des Lateinischen mit dem Falis-kischen untersucht. Die Autoren fiïhren den Beweis, daß das Faliskische keine lateinische Mundart, und zwar aus den folgenden drei Griinden: Ers tens erscheinen viele Eigenschaften, die sich in beiden Sprachen finden fassen, erst sehr spät im Faliskischen. Zweitens gibt es sehr alte Neuerungen, die beide Sprachen gemeinsam haben, und drittens gibt es einige Neuerungen im Faliskischen, die es von alien lateinischen Mundarten, sowohl solchen inner-halb als auch außerhalb Roms, trennen. Das Faliskische ist demnach eine Sprache, die einerseits mit dem Lateinischen verwandt, andererseits aber auch von ihm deutlich abgesetzt ist.
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De Lucia Brolli, Maria Anna, and Laura Maria Michetti. "La ceramica a rilievo di produzione falisca." Mélanges de l’École française de Rome. Antiquité 117, no. 1 (2005): 137–71. http://dx.doi.org/10.3406/mefr.2005.10943.
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Garbowski, Tomasz. "Optymalna tektura falista – czyli jaka?" PRZEGLĄD PAPIERNICZY 1, no. 9 (September 15, 2022): 59–66. http://dx.doi.org/10.15199/54.2022.9.1.
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BARANEK, EL�BIETA. "Jakie tektury faliste s� dobre dla IKEA." PRZEGL�D PAPIERNICZY 1, no. 3 (March 5, 2015): 43–46. http://dx.doi.org/10.15199/54.2015.3.2.
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VERREYKE, Hélène. "The Faliscan Red-Figured Stamnos of Ghent University." BABESCH - Bulletin Antieke Beschaving 77 (January 1, 2002): 43–48. http://dx.doi.org/10.2143/bab.77.0.94.
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Pola, Angela, and Rex Wallace. "A Dipinto on a Faliscan Kylix." Glotta 98, no. 1 (March 22, 2022): 253–62. http://dx.doi.org/10.13109/glot.2022.98.1.253.
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Lemieux, Raymond. "FALISE, Michel, RÉGNIER, Jérôme, Économie et foi." Laval théologique et philosophique 50, no. 2 (1994): 459. http://dx.doi.org/10.7202/400863ar.
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Wallace, Rex E., and Brian D. Joseph. "On the Development of PIE *gh/gh in Faliscan." Diachronica 10, no. 1 (January 1, 1993): 144–50. http://dx.doi.org/10.1075/dia.10.1.16wal.
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Noszczyk, Paweł. "Termoizolacyjność materiałów pochodzenia celulozowego – tektura falista i plaster miodu." MATERIAŁY BUDOWLANE 1, no. 11 (November 29, 2022): 158–60. http://dx.doi.org/10.15199/33.2022.11.44.
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Vendrell Cabanillas, David. "Bañistas en una cratera de cáliz falisca conservada en el Museo Nacional de Dinamarca. Una propuesta de lecturas." Lucentum, no. 40 (July 22, 2021): 111. http://dx.doi.org/10.14198/lvcentvm.18383.
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El siguiente artículo presenta un vaso procedente del Museo Nacional de Dinamarca en Copenhague, el cual se trata de una cratera de cáliz falisca de figuras rojas fechada a principios del siglo IV a. C. y procedente cerca del Monte Soracte (próximo a la localidad italiana de Sant'Oreste). En ella vemos, por un lado, una escena de baño femenino y, por otro lado, una escena de conversación en la palestra; unas imágenes que reformulan los modelos artísticos áticos creados desde mediados/finales del siglo V a. C. A tal efecto, se lleva a cabo una descripción detallada del vaso y un análisis estilístico, compositivo e iconográfico con el fin de formular una hipotética afiliación y autoría, y una nueva lectura interpretativa.
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Maras, Daniele Federico. "Le scritture dell'Italia preromana." Palaeohispanica. Revista sobre lenguas y culturas de la Hispania Antigua, no. 20 (May 1, 2020): 923–68. http://dx.doi.org/10.36707/palaeohispanica.v0i20.386.
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La scrittura è stata introdotta nell’Italia antica attraverso il contatto tra i navigatori greci e le aristocrazie etrusche dell’età Orientalizzante. Entrando a far parte dei rapporti cerimoniali tra pari, si è diffusa rapidamente presso le popolazioni vicine e nel corso del VI secolo a. C. ha assunto un valore identitario etnico, dando vita a un mosaico di diverse tradizioni grafiche, volta per volta derivate direttamente dalla scrittura greca o attraverso la mediazione etrusca o latina. L’autore dedica alcune pagine introduttive al processo storico di trasmissione e adattamento della scrittura e poi passa in rassegna i domini epigrafici etrusco, falisco, latino, celtico, veneto, retico, camuno, paleo-italico, paleo-sabellico, ausone, osco e umbro. In conclusione, alcuni spunti per la ricerca futura vengono brevemente accennati.
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Loreto, Luigi. "Il conflitto romano-falisco del 241/240 a.C. e la politica romana degli anni successivi." Mélanges de l’École française de Rome. Antiquité 101, no. 2 (1989): 717–37. http://dx.doi.org/10.3406/mefr.1989.1646.
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Poręba, Karol. "Linia falista i totalność. Efektowność i efektywność poezji Kamili Janiak." Śląskie Studia Polonistyczne 14, no. 2 (December 28, 2019): 163–72. http://dx.doi.org/10.31261/ssp.2019.14.11.
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The aim of this article is to discuss poetic works by Kamila Janiak using categories of showiness (a formal surplus) and efficiency (understood as critical or per-formative potential). The author of the article comments upon the early reception of Janiak’s poems to point that first reviewers oftentimes intuitively indicated the totality of Janiak’s poetic gestures, and then he traces the poetess’s strategy back to Camp aesthetics.
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Picard, Marc. "On the Evolution of PIE *gh in Latin and Faliscan." Diachronica 10, no. 1 (January 1, 1993): 139–43. http://dx.doi.org/10.1075/dia.10.1.15pic.
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Drigo, Jasmim. "As Línguas da Itália Antiga: um Breve Panorama." Mare Nostrum (São Paulo) 8, no. 9 (February 15, 2018): 117. http://dx.doi.org/10.11606/issn.2177-4218.v8i9p117-130.
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Este artigo traça um panorama das línguas de maior expressão da Itália Antiga durante os séculos VI a I a.C. As línguas indo-europeias itálicas recebem mais atenção neste estudo por se tratarem de línguas com mais vestígios textuais e por serem mais inteligíveis que as demais, são elas: latim-falisco, úmbrio, osco e piceno meridional. As indo-europeias não itálicas apresentam similaridades com as itálicas, mas ainda assim são menos inteligíveis, são elas: venético e messápico. As línguas não indo-europeias apresentam estruturas fonológicas, morfológicas e sintáticas diferentes e menos vestígios textuais, por isso são mais complicadas de se analisar, são elas: etrusco, rético e piceno setentrional. O objetivo desse panorama é demonstrar a diversidade linguística da região e apresentar bibliografia atualizada e relevante sobre o assunto.
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Bakkum, Gabriël. "The Latin Dialect of the Ager Faliscus: 150 Years of Scholarship." Mnemosyne 62, no. 4 (2009): 704. http://dx.doi.org/10.1163/156852510x456255.
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Berenguer Sánchez, José A., and Eugenio R. Luján Martínez. "Falisco faced y el perfecto de *dheh1-k- ‘hacer’ en las lenguas itálicas." Emerita 73, no. 2 (December 30, 2005): 197–216. http://dx.doi.org/10.3989/emerita.2005.v73.i2.42.
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Schinkel, Wolfgang. "Erste Erfahrungen beim Einsatz von Falisan-Universal-Flüssigbeize (FL 398) unter praktischen Bedingungen." Archives Of Phytopathology And Plant Protection 21, no. 5 (January 1985): 383–401. http://dx.doi.org/10.1080/03235408509435967.
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Downes, Sophy. "Head of an athlete from Falerii Novi." Papers of the British School at Rome 73 (November 2005): 265–72. http://dx.doi.org/10.1017/s0068246200003044.
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RELAZIONE DI SCAVO: TESTA DI UN ATLETA DA FALERII NOVIL'articolo presenta una testa scultorea di marmo trovata nel 1997 durante le ricognizione eifettuate a Falerii Novi nell'ambito del Progetto Valle del Tevere. La testa viene collocata nel genere delle sculture romane idealizzanti, e datata al I secolo a.C. grazie al confronto con altre statue ellenizzanti coeve. Si considera anche la scultura nel contesto storico di Falerii Novi e Veteres, in particolare le possibili origini falische della nuova città e si esaminano i dati degli scavi condotti nel sito nel XIX secolo per suggerire una possibile punto di ritrovamento e di esposizione nel teatro e nel complesso termale della città.
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Trevizam, Matheus. "Modos de inserção do Cinegético, de Grattius Faliscus, na tradição da poesia didática antiga." Phoînix 23, no. 1 (June 30, 2017): 140–57. http://dx.doi.org/10.26770/phoinix.v23n8.
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Martelli, Maria Paola, Roberta Rossi, Emanuela Varasano, Giorgina Specchia, Francesco Di Raimondo, Giuseppe Avvisati, Enrico Tiacci, Franca Falzetti, Paolo Sportoletti, and Brunangelo Falini. "Identification and Characterization of Novel Rare Nucleophosmin (NPM1) Gene Mutations in Acute Myeloid Leukemia (AML) By a Combinatorial Approach of Immunohistochemistry and Molecular Analyses." Blood 128, no. 22 (December 2, 2016): 1717. http://dx.doi.org/10.1182/blood.v128.22.1717.1717.
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Abstract Introduction. Nucleophosmin (NPM1) gene mutations occur in 50-60% of adult AML with normal karyotype (Falini et al, NEJM 2005). About 50 NPM1 mutations have been so far identified, all clustering in exon-12 (Falini et al, Blood 2007) but few sporadic cases involving either exon-9 (one) (Mariano et al, Oncogene 2006) or exon-11 (two) (Albiero et al, Leukemia 2007). In spite of molecular heterogeneity, all mutations cause common changes at the C-terminus of NPM1 mutants, i.e. loss of tryptophans 288 and 290 (or 290 alone) and creation of a new nuclear export signal (NES) motif (Falini et al, Blood 2006a).As a consequence, all NPM1 mutants aberrantly accumulates in the cytoplasm of leukemic cells and can be detected by immunohistochemistry, which is fully predictive of NPM1 gene mutations (Falini et al, Blood 2006b). Methods. From 2005 to 2015, 702 AML patients samples were analyzed at diagnosis by both immunohistochemistry (IHC) for NPM1 subcellular localization and western blot (WB) with anti-NPM1 mutant specific rabbit polyclonal antibodies antibodies, produced in our laboratory (Martelli et al, Leukemia 2008). Discordant cases were further analyzed by NPM1 gene Sanger sequencing. Newly discovered NPM1 mutated genes were subcloned in pEGFP-C1 vector and transiently expressed in NIH-3T3 adherent cells to study the NPM1 mutant subcellular localization by immunofluorescence microscopy. The NESbase version 1.0 program was used to identify putative NES within the new protein sequence, and their efficiency was evaluated by the pREV1.4-based NES efficiency assay, as previously described (Bolli et al, Cancer Res 2007). Results. At IHC and WB analyses, concordance in diagnosis was obtained in 695/702 samples (291 NPM1-mutated and 404 NPM1-unmutated AML). In 7/702 (1%), IHC detected cytoplasmic NPM1 whilst WB with anti-NPM1 mutant antibodies was negative. Unfortunately, in 3 out of these cases, the original patient sample was not available for further analyses. In the other 4, exon-12 NPM1 gene sequence was wild-type (WT), in keeping with the negative WB results. One of these cases harbored the previously described exon-11 NPM1 mutation, in 1 case no mutation was detected (further studies are ongoing), and in 2 cases new mutations involving exon-6 were discovered. Strikingly, in the latter cases, WB analysis with different anti-NPM1 antibodies revealed a new band at different molecular weight (MW) than NPM1-WT. Indeed, in 1 case an in frame 21 nucleotides insertion at exon-6 lead to a 7 aa longer than WT protein, whilst in the other a 19 nucleotides insertion created a new stop codon leading to a truncated protein. In both cases, a new NES motif was created. Importantly, cell transfection experiments confirmed that the new NPM1 mutants localized at least partly in the cytoplasm, and the pREV1.4-based NES efficiency assay showed the new NES were active. Conclusions. Here, we report on the identification and functional characterization of two novel NPM1 mutations in AML. Our observations further support the view that cytoplasmic NPM1 dislocation is a critical step in leukemogenesis, and that immunohistochemistry, that detects, through cytoplasmic dislocation on NPM, 'all types' of NPM1 mutations, might be used as first step for directing further molecular studies. Disclosures Di Raimondo: Janssen-Cilag: Honoraria.
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Ambrosini, Laura. "Su un elmo falisco a figure rosse da Cerveteri e sulla deposizione di elmi fittili nei corredi tombali di età ellenistica." Mélanges de l’École française de Rome. Antiquité 118, no. 1 (2006): 251–66. http://dx.doi.org/10.3406/mefr.2006.10983.
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Gilotta, Fernando. "Chiusi e il Clusium Group. Un nuovo documento dagli scavi di Orvieto." Opuscula. Annual of the Swedish Institutes at Athens and Rome 3 (November 2010): 179–84. http://dx.doi.org/10.30549/opathrom-03-08.
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This note deals with sherds of a very important “new” Etruscan red-figure cup from Orvieto (Excavations Campo della Fiera, 2006), showing a fragmentary group of Fufluns/Satyr and a winged female goddess. The poorly preserved paintings, close to the “Clusium Group” as far as the central medaillon is concerned, are reminiscent of older “tiberine” vases, such as the Casuccini stamnos and related pottery, and at the same time show intriguing links with later Faliscan and Campanizing red-figure. This combination of stylistic and workshop relationships sheds light on the milieu from which the Clusium Group (possibly) emerged around the middle of the fourth century BC. As for the kylix, a date toward the third quarter of the fourth century BC is suggested.
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Nida, Nushrotun. "حقائق الحياة الفلسطينية في الشعر "يوميات جرح فلسطين" لمحمود درويش." Journal of Arabic Literature (Jali) 2, no. 2 (June 30, 2021): 135–50. http://dx.doi.org/10.18860/jali.v2i2.12065.
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Talking about Mahmud Darwis works is as if we were invited to see the real world reality. In this study, the researcher used the object of Mahmud Darwis' poetry entitled "yaumiyyatu Jurhi Falistin" because the poem depicts the real life of the Palestinian people, which is full of sadness and suffering. Therefore, this study aims to determine the real life of the Palestinian people which is described in the poem “yaumiyyatu jurhi falistiin” with the sociology of literature theory by Alan Swingewood and descriptive qualitative methods. The results of the reality of the life of the Palestinian people are described in Mahmud Dawis poetry, namely war, sadness, death and also the patriotism of the Palestinian people in defending their country.
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Cifani, Gabriele, Rachel Opitz, and Simon Stoddart. "Mapping the Ager Faliscus road-system: the contribution of LiDAR (light detection and ranging) survey." Journal of Roman Archaeology 20 (2007): 165–76. http://dx.doi.org/10.1017/s1047759400005353.
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Simón Cornago, Ignacio. "Adaptations of the Latin alphabet." Palaeohispanica. Revista sobre lenguas y culturas de la Hispania Antigua, no. 20 (May 1, 2020): 1067–101. http://dx.doi.org/10.36707/palaeohispanica.v0i20.387.
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The aim of this paper is to offer an overview of the use of the Latin alphabet to write the so-called fragmentary languages of Italy and Western Europe during Antiquity. The Latin alphabet was created from an Etruscan model to write Latin, but was also used to record texts in other languages: Etruscan, Oscan, Umbrian, the minor Italic dialects, Faliscan, and Venetic in Italy; Gaulish in the Gauls and other provinces in the north of Europe; and, finally, Iberian, Celtiberian, and Lusitanian in the Iberian Peninsula. The use of the Latin alphabet to write the so-called fragmentary languages represents a step before complete Latinisation. Two models are proposed to explain how the use and/or adaptation of the Latin alphabet to write the local languages came about.
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Goldstein, David. "Angelo Mercado: Italic Verse. A Study of the Poetic Remains of Old Latin, Faliscan, and Sabellic." Gnomon 87, no. 8 (2015): 695–703. http://dx.doi.org/10.17104/0017-1417-2015-8-695.
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Spurway, John. "Hiki Mo e Faliki: Why Ma'afu Brought his Floor Mats to Fiji in 1847." Journal of Pacific History 37, no. 1 (June 2002): 5–23. http://dx.doi.org/10.1080/00223340220139243.
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Minor, Tomasz. "Analiza możliwości stosowania systemów faliście giętkich przewodów ze stali nierdzewnej w instalacjach gazowych w budynkach w Polsce." Nafta-Gaz 76, no. 3 (March 2020): 176–85. http://dx.doi.org/10.18668/ng.2020.03.04.
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Mancini, Marco. "Does Prenestinian fe⋮faked actually exist?" Journal of Latin Linguistics 20, no. 1 (June 25, 2021): 75–108. http://dx.doi.org/10.1515/joll-2021-2019.
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Abstract After more than a century since its discovery, the mystery of the Fibula Praenestina has been definitively solved. The artifact and the inscription are both authentic beyond any reasonable doubt. Complex spectrographic analyses published a few years ago have confirmed that the Fibula is not a forgery. However, quite paradoxically, an Early Latin reduplicated perfect fefaked is still implausible from a morphological point of view. This form continues to disturb the Early Latin linguistic framework, which can be reconstructed thanks to the available data at our disposal. The article presents a new reading of the text, which on the one hand confirms the congruity of the preterite morphology (not a reduplicated form of the root *d h ē- / d h ǝ-, but an ancient aorist similar to Faliscan făced / făcet) and on the other gives an account of the abnormal use of punctuation between <whe> and <wha>.
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Martelli, Maria Paola, Valentina Pettirossi, Christian Thiede, Elisabetta Bonifacio, Mauro Di Ianni, Ilaria Gionfriddo, Debora Cecchini, et al. "Dissecting the Hierarchical Level of Hematopoietic Progenitors' Involvement in AML with NPM1 Gene Mutation and Their Engraftment Potential in Immunocompromised Mice." Blood 114, no. 22 (November 20, 2009): 480. http://dx.doi.org/10.1182/blood.v114.22.480.480.
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Abstract Abstract 480 Acute myeloid leukemia with mutated NPM1 gene and cytoplasmic nucleophosmin (NPMc+ AML) [Falini B et al, NEJM 2005;352:254-266] is a new entity of WHO classification that shows distinctive biological and clinical features [Falini B et al, Blood 2007;109:874-885] which include negativity for CD34 antigen expression at both immunohistochemistry and gene expression profiling. Flow cytometric analysis shows that, in most NPM1-mutated AML, percentages of CD34+ cells are in the low range (< 5-10%). Detection of NPM1 mutations by molecular techniques and/or immunohistochemistry and Western Blot analysis with specific antibodies provides an important tool for tracking the genetic lesion in leukemic cells at different hierarchical stage. We previously reported involvement by NPM1 gene mutation of the CD34+ cell fraction isolated from patients with NPM1-mutated AML, and, in one case, the involvement, in particular, of the early progenitor CD34+/CD38- [Martelli MP et al, Blood (ASH Annual Meeting Abstracts) 2008;112:307]. Here we expand and confirm our previous observation in 5 cases of CD34-negative NPM1-mutated AML. CD34+/CD38- cells were isolated by either FACS (3 cases, purity >98%) or MACS-sorting (2 cases, purity >92%) and analyzed by molecular analysis and Western Blot with a specific anti-NPM1 mutant antibody, respectively. The presence of either NPM1 gene mutation or mutant protein was demonstrated in all samples analyzed proving the CD34+/CD38- cells belong to the leukemic clone. This cell subpopulation displayed also immunophenotypic features classically associated to leukemic stem cells (LSCs) (CD123+/CD33+/CD90-) in all (16/16) samples analyzed, suggesting they might actually represent the LSCs in NPM1-mutated AML. Indeed, CD34+ cell fraction isolated from NPM1-mutated AML was able to generate leukemia in immunocompromised mice resembling the original patient's disease. However, there is experimental evidence that, at least in some CD34-negative AML, also the CD34- population may contain LSCs. Whether the CD34- cell compartment in NPM1-mutated AML is also able to engraft and outgrow into leukemia in mice remains to be clarified. For this purpose, we assessed the engraftment ability of CD34- cells from 5 NPM1-mutated AML patients. No engraftment was observed in one case. Interestingly, in three patients with myelomonocytic (M4, 2 cases) and myelocytic (M2, 1 case) AML, the CD34- fraction resulted into marrow engraftment by human CD45+/CD33+ myeloid cells that, at morphological and immunohistological grounds, consisted of a mixed population of macrophage cells expressing the CD68 (PG-M1) antigen and mature looking myeloperoxidase (MPO)-positive cells. This pattern possibly reflects short-term engraftment by leukemic cells devoid of self-renewal potential that differentiated into mature elements. However, the neoplastic nature of engrafted cells could be established with certainty only in one case by western blotting detection of NPM1 mutant protein. Immunohistochemistry could not help in these cases to establish the leukemic nature of human cells since terminally differentiated leukemic cells in NPM1-mutated AML show nucleus-restricted NPM1 positivity. In contrast, the pure CD34+ fraction (availabel for comparison in one of these three cases) engrafted as AML with clear blastic morphology and cytoplasmic dislocation of nucleophosmin. In a fourth patient, the highly purified CD34- fraction from relapsed NPM1-mutated AML engrafted in mice with a typical AML picture. These preliminary findings suggest that in general the CD34- fraction from NPM1-mutated AML may have more limited engraftment potential than the CD34+ fraction. Further studies are ongoing to address this issue. Disclosures: Falini: Xenomics: Patents & Royalties.
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CLINE, ANDREW R. "Revision of the sap beetle genus Pocadius Erichson, 1843 (Coleoptera: Nitidulidae: Nitidulinae)." Zootaxa 1799, no. 1 (June 16, 2008): 1. http://dx.doi.org/10.11646/zootaxa.1799.1.1.
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A total of 47 species are included in a revisionary treatment of Pocadius Erichson. Twenty-one species are redescribed, P. yunnanensis Grouvelle is resurrected, and 25 are described as new, including: P. antennuliferus (Brazil), P. ashei (Bolivia), P. barclayi (Sulawesi), P. bicolor (Brazil), P. carltoni (Nicaragua), P. centralis (Central America), P. cochabambus (Bolivia), P. coxus (Brazil), P. crypsis (Guyana), P. dominicus (Dominican Republic), P. endroedyi (southern Africa), P. falini (Paraguay), P. fasciatus (Borneo), P. femoralis (Vietnam), P. fusiformis (Sulawesi), P. globularis (Honduras), P. insularis (Trinidad), P. kirejtshuki (Australia), P. luisalfredoi (Mexico), P. nigerrimus (Paraguay), P. okinawaensis (Okinawa), P. pecki (Venezuela), P. peruensis (Peru), P. tepicensis (Mexico), P. wappesi (Bolivia). An adult and larval description for the genus also is provided and its phylogenetic position within Nitidulinae discussed. A key to all species is included, as well as a checklist of species and their distributions.
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Beziat, Guillaume, Suzanne Tavitian, Sarah Bertoli, Francoise Huguet, Laetitia Largeaud, Francois Vergez, Jean-Baptiste Rieu, Pierre Bories, Eric Delabesse, and Christian Recher. "Dactinomycin in Acute Myeloid Leukemia with NPM1 Mutations." Blood 134, Supplement_1 (November 13, 2019): 3900. http://dx.doi.org/10.1182/blood-2019-125782.
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NPM1 mutations are frequent in acute myeloid leukemia (AML) and define a distinct entity according to the 2016 WHO classification. NPM1 mutations are generally associated with chemosensitivity and a favorable prognosis. However, outcome may vary according to co-mutational events, and still approximately 40% of patients relapse after achieving complete response. Wild-type NPM1 is mainly located in the nucleolus where it plays a key role in the regulation of ribosome biogenesis, protein synthesis and tumor suppression through TP53 activation. Mutated NPM1 loses its predominant nucleolar location and accumulates in cytoplasm contributing to leukemogenesis (Falini B, Blood 2011). Moreover, this mutational event leads to haploinsufficiency and cytoplasmic retention of wild type NPM1 creating a vulnerability to nucleolar stress. Indeed, complete responses have been observed in NPM1-mutated AML patients with dactinomycin, a nucleolar stress-inducing drug (Falini B, NEJM 2015). Here, we report our experience of off-label dactinomycin in untreated or relapsed/ refractory NPM1-mutated AML. Inclusion criteria for this retrospective study were: age ≥ 18 years-old, AML with NPM1 mutation, relapsed or refractory disease as well as treatment-naive patients unfit for intensive chemotherapy. Patients should also have completed one cycle of dactinomycin 12.5 µg/kg/day for 5 days every 28 days. From September 2015 to February 2019, 26 patients received dactinomycin. Median age was 62.5y, WBC count was > 50 giga/L in 8 patients (31%), 13 patients (50%) had FLT3-ITD mutation whereas 10 (38%) and 11 (42%) patients were classified as favorable or intermediate-I according to the ELN-2010 classification. There were 7 (27%) relapses post-allogeneic transplantation. Median number of dactinomycin cycle was 1 (1-8) and 7 patients (27%) received more than 3 cycles. Sorafenib was added in 6 patients with associated FLT3-ITD mutations whereas 2 others patients received ATRA in combination with dactinomycin. Dactinomycin was administered in different situations: front-line treatment in 4 unfit patients (16%); morphologic (n=16, 62%) or molecular relapses (n=4, 16%) following intensive chemotherapy, refractory disease (n=1, 13%) or post remission therapy in second complete response (CR) following salvage chemotherapy (n=1, 13%). Three out of 17 patients (18%) in morphologic relapse or refractory to chemotherapy reached complete remission after the first cycle of dactinomycin. The duration of response was 4 and 6 months in 2 patients whereas the third patient is still in CR 3 years after dactinomycin. One out of 4 patients in molecular relapses achieved a complete molecular remission with dactinomycin. None of the 4 patients unfit for intensive chemotherapy responded to dactinomycin as front-line therapy. The only patient treated in post-CR2 with dactinomycin achieved a complete molecular remission before allogeneic transplantation. Overall, 5 patients (19%) appeared to benefit from dactinomycin treatment. Grade 3-4 adverse events were thrombocytopenia (n=11, 42%), neutropenia (n=11, 42%), GI toxicity (n=6, 23%), mucositis (n=5, 19%), lung infection (n=5, 19%) and skin rash (n=2, 7.6%). Dactinomycin is an inexpensive and easily available drug that may induce significant responses in AML patients with NPM1 mutations with an acceptable safety profile. Prospective and controlled clinical trials are mandatory to clearly define the role of this agent in AML with NPM1 mutations. Disclosures Tavitian: Novartis: Membership on an entity's Board of Directors or advisory committees. Bertoli:Sanofi: Honoraria. Huguet:Incyte Biosciences: Honoraria; Servier: Honoraria; Amgen: Honoraria; Pfizer: Honoraria; BMS: Honoraria; Jazz Pharmaceuticals: Honoraria; Novartis: Honoraria. Bories:Abbvie: Consultancy. Recher:Novartis: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Incyte: Honoraria; Abbvie: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Jazz: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Celgene: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Macrogenics: Consultancy, Membership on an entity's Board of Directors or advisory committees; Astellas: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Amgen: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Sunesis: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Astellas: Consultancy, Membership on an entity's Board of Directors or advisory committees. OffLabel Disclosure: NPM1 mutations are frequent in acute myeloid leukemia (AML) and define a distinct entity according to the 2016 WHO classification. Wild-type NPM1 is mainly located in the nucleolus where it plays a key role in the regulation of ribosome biogenesis, protein synthesis and tumor suppression through TP53 activation. Mutated NPM1 loses its predominant nucleolar location and accumulates in cytoplasm contributing to leukemogenesis (Falini B, Blood 2011). Moreover, this mutational event leads to haploinsufficiency and cytoplasmic retention of wild type NPM1 creating a vulnerability to nucleolar stress. Indeed, complete responses have been observed in NPM1-mutated AML patients with dactinomycin, a nucleolar stress-inducing drug (Falini B, NEJM 2015).
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Halldórsson, Viðar. "Sjónræn félagsfræði: að sjá og greina samfélagið í gegnum myndavélina." Tímarit um uppeldi og menntun 29, no. 1 (June 23, 2020): 21–44. http://dx.doi.org/10.24270/tuuom.2020.29.2.
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Eitt meginmarkmið kennslu í félagsfræði er að hjálpa nemendum að verða læsir á samfélagið, meðal annars með því að þróa með sér félagsfræðilegt innsæi (e. sociological imagination). Kennsluhættir í félagsfræði hafa um langa hríð falist að miklu leyti í því að láta nemendur lesa félagsfræði í stað þess að sjá félagsfræði en sjónræn félagsfræði (e. visual sociology) hefur verið að ryðja sér til rúms á síðustu áratugum sem viðurkennd kennslu- og rannsóknaraðferð innan félagsvísinda. Í þessari grein fjalla ég um það hvernig hægt er að nýta sjónræna félagsfræði, í þessu tilfelli ljósmyndaritgerðir, til þess að þjálfa og þróa félagsfræðilegt innsæi nemenda á efri skólastigum. Til að lýsa þessu greini ég fjórar af mínum eigin ljósmyndum út frá ýmsum hugmyndum, hugtökum og kenningum félagsfræðinnar. Greiningu myndanna er ætlað að vekja athygli á því hvernig nýta má ljósmyndun og ljósmyndaritgerðir til samfélagslegrar greiningar og til kennslu í félagsfræði með hliðsjón af lykilmarkmiðum sem lagt er upp með í aðalnámskrám grunn- og framhaldsskóla.
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Martelli, Maria Paola, Valentina Pettirossi, Elisabetta Bonifacio, Federica Mezzasoma, Nicla Manes, Debora Cecchini, Maruska Capanni, et al. "Evidence for CD34+ Hematopoietic Progenitor Cell Involvement in Acute Myeloid Leukemia with NPM1 Gene Mutation: Implications for the Cell of Origin." Blood 112, no. 11 (November 16, 2008): 307. http://dx.doi.org/10.1182/blood.v112.11.307.307.
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Abstract Acute myeloid leukemia expressing mutated NPM1 gene and cytoplasmic nucleophosmin (NPMc+ AML) [Falini B et al, NEJM2005;352:254–266] is a new entity of WHO classification that shows distinctive biological and clinical features, including a unique molecular signature characterized by downregulation of CD34 and upregulation of most HOX genes [Falini B et al, Blood2007;109:874–885]. Involvement of HOX genes in the maintenance of the stem-cell phenotype strongly suggest that AML with mutated NPM1 originates from a multipotent hematopoietic progenitor (HSC). This view is also supported by immunohistological findings showing that AML with mutated NPM1 frequently displays multilineage involvement [Pasqualucci L et al, Blood2006;108:4146–4155]. On the other hand, the frequent negativity of NPMc+ AML for the HSC-associated antigen CD34 raises the question of whether the mutation event occurs in a CD34-negative HSC (these cells have been identified in mice) or whether a minimal pool of CD34-positive NPM1-mutated leukemic cells does exist. Currently, the hierarchical level of stem cell involvement in NPMc+ AML is unknown. To address this issue, we purified CD34+ cells from NPMc+ AML patients and detected NPM1 mutant protein in the sorted population by Western blot with anti-NPM mutant specific antibodies [Martelli MP et al, Leukemia 2008] (Figure 1A). We investigated 6 NPMc+ AML patients presenting at diagnosis with 0.12%, 0.14%, 0.38%, 5%, 22%, and 28% of CD34+ cells in the peripheral blood. In all cases, CD34+ fractions (purity >90%) harboured NPM1 mutant protein, indicating they belong to the leukemic clone (Figure 1B). The percentage of most undifferentiated CD34+/CD38− cells in the CD34+ fractions ranged from 5 to 97%. Notably, in at least one case, all CD34+ NPM1-mutated leukemic cells were CD38−negative. Moreover in all cases, CD34+ NPM1-mutated leukemic cells appeared to express CD123 (IL-3 receptor), considered a marker of the leukemic stem cell and target of potential therapy. Double staining of bone marrow biopsies with anti-CD34 and anti-NPM antibodies revealed that the rare CD34+ cells expressed NPM1 aberrantly in the cytoplasm. Inoculation of CD34+ NPM1-mutated AML cells into sublethally irradiated NOD/SCID mice resulted into leukemia engrafment in various body sites, especially bone marrow, spleen, lung and liver. Preliminary results showed that CD34+ leukemic cells reacquired the same leukemic phenotype as the original patient’s, including CD34-negativity of the leukemic bulk in spite of any lack of differentiation. This finding suggests that NPM1 mutant protein may be involved in downregulation of CD34 antigen, while keeping a gene expression profile typical of the hematopoietic stem cell. These findings suggest the CD34+ fraction contains the SCID-leukemia initiating cells (SL-IC) and point to CD34+/CD38− HSC as the cell of origin of AML with mutated NPM1. Figure Figure
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Martelli, M. P., V. Pettirossi, N. Manes, A. Liso, F. Mezzasoma, F. Cecchetti, M. F. De Marco, et al. "Selective Silencing of the NPM1 Mutant Protein and Apoptosis Induction upon ATRA In Vitro Treatment of AML Cells Carrying NPM1 Mutations." Blood 110, no. 11 (November 16, 2007): 868. http://dx.doi.org/10.1182/blood.v110.11.868.868.
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Abstract We previously identified a new AML category carrying NPM1 mutations which lead to aberrant cytoplasmic expression of the nucleolar protein NPM1, hence the term NPMc+ AML[Falini et al, NEJM 2005]. This leukemia accounts for about one-third of adult AML and shows distinctive biological and clinical features[Falini et al, Blood 2007]. Notably, AML carrying NPM1 mutations in the absence of FLT3-ITD are characterized by a favourable prognosis. However, still a proportion of NPMc+ AML cannot be cured by conventional treatments and new therapeutic strategies need to be explored. We previously identified OCI/AML3 as the only human AML cell line carrying cytoplasmic mutated NPM (type A) in the absence of FLT3-ITD[Quentmeier et al, Leukemia 2005]. Because of these features and the ability to engraft in NOD/SCID mice, the OCI-AML3 represents a remarkable tool for the study of NPMc+ AML. Previous findings that ATRA exerts growth inhibitory effects on the OCI/AML3 prompt us to investigate the molecular mechanisms underlying the response to ATRA, with focus on the NPM mutant protein. As cellular model for our studies, we also used primary leukemia cells originated from a patient with NPMc+ AML (mutation A) bearing FLT3-ITD (Mont1) that have been propagated in NOD/SCID mice for 5 years without loss of initial characteristics. Early cell cycle arrest and proapoptotic effects of pharmacological doses of ATRA were confirmed in both cellular models in vitro. Morphological signs of differentiation were not evident. Western blot analysis using specific antibodies showed marked downregulation of the leukemic NPM1 mutant protein upon ATRA treatment, preceding apoptosis activation. On the other hand, wild-type NPM1 protein levels remained unchanged, leading to a condition of NPM1 haploinsufficiency. Semi-quantitative RT-PCR for NPM mutant A showed no change in mRNA expression following treatment, suggesting a regulation of the NPM mutant protein expression at post-transcriptional level. Indeed, concomitant treatment with proteasome-inhibitors partly reverted this effect. Downregulation of NPM mutant protein preceded activation of caspase-8 and caspase-3, PARP-cleavage and Bax activation. No NF-kB activation was observed upon ATRA treatment. Activation of the p53-dependent pathway was a later event, as expected in conditions of NPM1 haploinsufficiency. Importantly, these results were confirmed in the primary NPMc+ AML cells from patient Mont1. Activation of caspase-8 suggests that the response to ATRA in NPMc+ AML cells may be mediated through the death receptor pathway. Although protein levels of TRAIL, TRAIL receptors and TNF-alpha receptors seem to be unaffected, it might be possible that the NPM1 mutant protein modulates the signalling through death cell receptors. Analysis of ATRA-induced transcriptome and proteome modifications in NPMc+ AML is ongoing and will be also presented, as well as further pre-clinical studies on patients’ primary AML cells and in NOD/SCID mice. In conclusion, our data suggest that NPM mutant protein might be involved in the in vitro response to ATRA in AML cells carrying NPM1 mutations. Figure Figure
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Bolli, Niccolo’, Maria Paola Martelli, Barbara Bigerna, Alessandra Pucciarini, Barbara Verducci, Teresa Pallotta, Felicetta de Marco, et al. "Reciprocal Interaction between NPM Leukemic Mutants and Arf: Structural Basis and Functional Consequences." Blood 108, no. 11 (November 16, 2006): 1939. http://dx.doi.org/10.1182/blood.v108.11.1939.1939.
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Abstract Mutations at exon-12 of nucleophosmin (NPM) gene are the most common gene lesion in Acute Myeloid Leukemia (AML) (Falini et al., NEJM, 352:254, 2005). They result indisruption of tryptophan (W) 288 and/or 290, constituting the Nucleolar Localization Signal (NoLS), andcreation of a new C-terminal Nuclear Export Signal (NES) motif, with 6 variations observed to date. Both alterations are necessary for aberrant NPM accumulation in leukemic cell cytoplasm (NPMc+ AML, Falini et al., Blood, 107:4514, 2006). In NPM mutants, there is a correlation between NES sequence and the type of NoLS disruption: the most common NES motif (LxxxVxxVxL) always associates with loss of both W288 and W290, e.g. mutant A; when retained, W288 always associates with rare NES variant sequences, such as LxxxLxxVxL in NPM mutant E. We demonstrated this correlation is explained by efficiency differences between NES motifs: NPM mutant A is not efficiently exported in cytoplasm upon artificial W288 reinsertion; the same happens when LxxxLxxVxL NES motif in mutant E is artificially replaced with LxxxVxxVxL, typical of mutant A. This suggest LxxxVxxVxL NES motif is weaker than the others, being unable to efficiently export mutant NPM to cytoplasm when artificially coupled with W288 (repesenting a partial NoLS). Such changes at NPM C-terminus also influence NPM-Arf binding and subcellular distribution. Tumor suppressor Arf is a major NPM interactor in the nucleolus, and its deregulation would be strongly implicated in leukemogenesis. In co-transfected cells, NPM leukemic mutants partially relocates Arf from nucleolus to nucleoplasm and cytoplasm and, in turn, Arf partially relocates NPM mutants A and E from cytoplasm to nucleus in a dose-related manner. Artificial NPM mutants carrying W288 coupled with LxxxVxxVxL NES motif show higher degree of co-localization with Arf, and lower doses of Arf are required for them to be completely relocated to nucleoli as compared to NPM leukemic mutants A and E. Co-immunoprecipitation studies show that leukemic mutants A and E bind less Arf than wild-type NPM or artificial NPM mutants. This obervation suggest that NPM leukemic mutants and Arf reciprocally interact and influence each otheri n a dose-related manner, with C-terminal NPM mutated sequence playing a role in Arf binding. Cytofluorimetric analysis of Arf-transfected NIH-3T3 cells shows G1 cell cycle arrest. Upon co-transfection, neither wild-type NPM nor leukemic or artificial NPM mutants are able to relieve Arf-induced cell cycle arrest. In conclusion, we suggest there is a “determinism” in the combination of NES motif/NoLS disruption: NPM mutants are selected for efficient cytoplasmic export and reduced Arf binding as compared to wild-type NPM. Both mechanisms may contribute to Arf dislocation/degradation, thus having the same functional consequences as NPM silencing; moreover, it is tempting to speculate that NPM leukemic mutants could be themselves less sensitive to ARF induced inhibition. Nevertheless, in our experimental model, changes in Arf subcellular distribution didn’t result in functional alterations. To clarify wether these findings will be relevant to the pathogenesis of NPMc+ AML, future studies should address in deeper detail the relationship between NPM and Arf doses and function in specific subcellular compartments.
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Quinteiro, Fabio B., and Ralph W. Holzenthal. "Fourteen new species ofOecetisMcLachlan, 1877 (Trichoptera: Leptoceridae) from the Neotropical region." PeerJ 5 (August 30, 2017): e3753. http://dx.doi.org/10.7717/peerj.3753.
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BackgroundThe caddisfly genusOecetiscurrently contains 534 valid species. Its larval stages are found in freshwaters around the world. The adults can be distinguished from other Leptoceridae by the unbranched forewing M vein and the exceptionally long maxillary palps. In the Neotropical region, 55 species ofOecetishave been recorded and most of them can be placed in one of the six species groups known from this biogeographical region: theavara-,falicia-,inconspicua-,punctata-,punctipennis-, andtestacea-groups. More than 50% of the known diversity of NeotropicalOecetishas been described in the past 40 years. Here, we describe an additional 14 new species ofOecetisto further document the diversity of this genus in the Neotropical region.MethodsThe descriptions and illustrations presented here are based on male specimens. Specimens were collected with Malaise traps or ultraviolet light traps. They were preserved in alcohol or pinned as stated in material examined section. Specimens had their genitalia prepared in 85% lactic acid to better observe internal characters and illustrations were aided by the use of a microscope with drawing tube attached.Results and DiscussionThis study raises the number of species ofOecetisin the Neotropics from 55 to 69. Eight of the new species presented here could not be reliably placed in one of the known species groups (Oecetis acuticlaspern. sp.,Oecetis flintin. sp.,Oecetis carinatan. sp.,Oecetis cassicoleatan. sp.,Oecetis blahnikin. sp.,Oecetis gibbosan. sp.,Oecetis licinan. sp., andOecetis pertican. sp.). The others are placed in thepunctata-group (Oecetis bidigitatan. sp.,Oecetis quasipunctatan. sp.),testacea-group (Oecetis plenuspinosan. sp.), andfalicia-group (Oecetis calorin. sp.,Oecetis hastapullan. sp.,Oecetis machaeran. sp.). Most of the diagnostic characters rely on structures of the inferior appendages and phallic apparatus, and the shape of tergum X.
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Czarnecka, Bożenna. "Living on the edge: studies on ecology of plant species and populations at the limits of their geographic range. Tribute to Professor Janusz B. Faliński (1934-2004)." Biodiversity Research and Conservation 37, no. 1 (March 1, 2015): 37–50. http://dx.doi.org/10.1515/biorc-2015-0001.
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Abstract Abies alba and Senecio rivularis - two of 44 mountain species reported from the Roztocze Highlands, SE Poland were objects of the study. Both species reach the north-eastern limits of their occurrence in this region. In case of Abies alba, the extent of its habitat niche and possibility of adaptation to alternative niches at the range limits were investigated in two areas of the Roztocze Highlands - the Roztocze National Park (RNP) and gorge sections of four river valleys (RV) of a mountainous character. In both landscapes, fir prefers mineral soils that are too leachy for deciduous species and even for spruce. In the RV sites, fir seems to have a much broader ecological scale and often colonizes organic soils with wet mixed coniferous forests with spruce, ash-alder, and bog alder forests. The studies on Senecio rivularis are an example of long-term ecological studies at the population level, conducted in the RNP since 1987, e.g., in terms of changes in the size structure of individuals compared to the changes in the surface area covered by this population. A nearly 3-fold increase in the area inhabited by the population was accompanied by changes in the spatial organisation of the population and individual size structure dynamics, which reflects the intensification of intra- and interspecific competition, and indicates condition changes in the population area.
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AlEnezia, Ahmed Farhan, Abdulkarem A. Alalwanya, M. N. A. Al-Falahi, and Saifuldeen A. Salima. "Study the Variations of Agricultural Land Degradation in Zawiyat Al-Dhban District (Abu Falis) within the Arid Environment of Anbar Governorate." IOP Conference Series: Earth and Environmental Science 1060, no. 1 (July 1, 2022): 012130. http://dx.doi.org/10.1088/1755-1315/1060/1/012130.
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Abstract A survey study was conducted on the lands of Zawiyat al-Dhaban district (Abu Falis) and calculated some physical and chemical characteristics and the state of fertile soil in an area of 3,926 square dunums, which is part of the flood plain of the Euphrates River, which is one of the advanced and promising provinces in Anbar Governorate, which was long ago a food basket that provides the people The region has various vegetable and fruit crops, but a rapid deterioration occurred in that province and the neighboring provinces, The human being has an important role in the process of changing these soils through the state of urban sprawl on agricultural soils of that province and the removal of irrigation and drainage canals, which led to an increase in the deterioration of its qualities and a decrease in its agricultural areas and increase Salt accumulations in it, the study area is located between longitude 43°30’0"-43°33’45" east and 33°22’30"-33°24’45"North, the study aims to create maps of temporal variances from the year 2000 to 2020, using remote sensing techniques, classifying them, and creating a predictive soil map for the salinity distributions in those soils, using the free-lance method, scenes from the satellite images of the US Landsat satellite were used. You will be obtained from sensors (ETM, TM) to characterize urban areas, vegetation layer, saline land, etc., for the years 2000-2020, depending on Program (ARCGIS-V9.1), (ARCGIS-V10) optical spectrum analyzes using the method Data-oriented classification, the study dealt with soil salinity in detail as it reflects the suitability of the soil for growing crops with a value of <2 dS.m-1 under the (USDA2017.soil survey manual). Handbook No. 18), the soil units were represented in 10 sites where a complete description of them was made and some physical and chemical characteristics of the soil samples were estimated. The results showed that a serious deterioration occurred within the years of comparison, where the plant area varied from 2826.7 to 2021.8 dun.2 by 72.0 to 51.5% for the years 2000. -2020, respectively, the area of saline soils is from 1052.1 to 1743.1 dun.2 by 26 to 44.4% for the years 2000-2020 respectively, while the area of urban expansion is from 47.1 to 160.9 dun.2, by 1.2 to 4.1% for the years 2000-2020 respectively. It was found, through the survey of the provincial soils, that about 14.1%, with a total area of 553.5 dun.2, its salinity range was 1.2-2.6 dS.m-1of the area of Zawiyat Dhban district. And in order to improve the production capacity of the province’s soils, the study recommends implementing practical measures that must be taken related to managing these soils, the most important of which is the immediate cessation of the operations of converting agricultural lands into urban areas, which is considered to be the destruction of the ecosystem, food security, and the violation of human rights. The right of future generations to deprive them of the best agricultural lands in those areas, and to follow careful soil management practices soils Residual of soils follow a fertilization plan to increase the amount of beneficial elements for plant growth in addition to using new irrigation methods. In order to suit the soil for cultivation in those regions.
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Chatzimanolis, Stylianos, and James Ashe. "Revision and phylogeny of the Neotropical genus Philothalpus Kraatz (=Eugastus Sharp and Allostenopsis Bernhauer) (Coleoptera: Staphylinidae: Xanthopygina)." Insect Systematics & Evolution 36, no. 1 (2005): 63–119. http://dx.doi.org/10.1163/187631205788912813.
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AbstractThe staphylinid genus Philothalpus is revised. The species of Allostenopsis Bernhauer and Eugastus Sharp are shown to be congeneric with Philothalpus fervidus (the type species of Philothalpus), and consequently, Allostenopsis Bernhauer and Eugastus Sharp are placed as junior synonyms of Philothalpus Kraatz. Allostenopsis kraatzi Bernhauer is shown to be a junior synonym of A. antennaria Bernhauer. Seventeen species are described as new: P. asymmetros sp. n. from Ecuador, P. bilobus sp. n. from French Guiana, Guyana and Suriname, P. brooksi sp. n. from Colombia, Ecuador and Panama, P. chloropennis sp. n. from Panama, P. chotaenus sp. n. from Colombia, P. ecuadorensis sp. n. from Ecuador, P. falini sp. n. from Costa Rica and Nicaragua, P. loksos sp. n. from Colombia, Ecuador and Peru, P. mauroprasinus sp. n. from Guyana, P. nitidus sp. n. from Brazil, P. osanus sp. n. from Costa Rica, P. pecki sp. n. from Brazil and Peru, P. porphyros sp. n. from Ecuador, P. portokalis sp. n. from Ecuador, P. rufus sp. n. from Panama, P. rugosus sp. n. from Panama, and P. stravos sp. n. from Ecuador and Peru. Lectotypes are designated for Eugastus mundus Sharp, Philonthus fervidus Erichson, and Stenopsis kraatzi Bernhauer. Distributional maps, a key and illustrations of structural features including aedeagi are provided for the identification of the known species. Phylogenetic analysis of three outgroup and 21 ingroup taxa based on 43 characters resulted in three equally most parsimonious trees (CI = 0.48, RI = 0.66). The monophyly of Philothalpus is supported by high Bremer support and bootstrap values.
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Braun, Sharon, and Emily Barr. "Gluten-Free Friends: An Activity Book for Kids by Nancy Patin Falini, MA, RD, LDN • Centennial, CO: Savory Palate Inc. • 2004 • 57 pages • $18.95 • ISBN: 1889374091." ICAN: Infant, Child, & Adolescent Nutrition 1, no. 4 (August 2009): 235. http://dx.doi.org/10.1177/1941406409340406.
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Pitiot, A. S., I. Santamaría, O. García-Suárez, I. Centeno, A. Astudillo, C. Rayón, and M. Balbín. "Reply to ‘Aberrant cytoplasmic expression of C-terminal truncated NPM leukaemic mutant is dictated by tryptophans loss and a new NES motif’ by Falini et al." Leukemia 21, no. 9 (July 19, 2007): 2054. http://dx.doi.org/10.1038/sj.leu.2404840.
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Tiacci, Enrico, Gianluca Schiavoni, Maria Paola Martelli, Emanuela Boveri, Roberta Pacini, Alessia Tabarrini, Silvia Zibellini, et al. "Constant Activation of the RAF-MEK-ERK Pathway As a Diagnostic and Therapeutic Target in Hairy Cell Leukemia." Blood 120, no. 21 (November 16, 2012): 2657. http://dx.doi.org/10.1182/blood.v120.21.2657.2657.
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Abstract Abstract 2657 The BRAF-V600E mutation defines genetically hairy cell leukemia (HCL) among B-cell leukemias and lymhphomas. In solid tumors, BRAF-V600E is known to aberrantly activate the oncogenic MEK-ERK pathway, and targeted BRAF and/or MEK inhibitors have shown remarkable efficacy in clinical trials of melanoma patients. However, the MEK-ERK pathway status in HCL has not been thoroughly investigated so far. Therefore, as a read-out of MEK-ERK pathway activation, we assessed phospho-ERK expression in 37 HCL patients using immunohistochemistry on routine biopsies and/or Western blotting on purified leukemic cells. Beside confirming the constant presence of BRAF-V600E in all patients, we documented ubiquitous phospho-ERK expression in HCL. Conversely, all 44 HCL-like cases in parallel studied (40 splenic marginal zone lymphoma, 2 HCL-variant and 2 splenic lymphoma/leukemia unclassifiable) were devoid of BRAF-V600E and none expressed phospho-ERK. Lack of phospho-ERK expression was also documented in two exceptionally rare cases of non-HCL CD5-negative B-cell lymphoproliferative disorders not otherwise specifiable that were previously described to harbour the BRAF-V600E mutation on allele-specific PCR (Arcaini et al, Blood 2012;119:188–191), pointing to the presence of this mutation in only a small part of the leukemic clone in these cases. Our findings support the use of phospho-ERK immunohistochemistry in the differential diagnosis between HCL and HCL-like neoplasms and establish the MEK-ERK pathway as a rational therapeutic target in HCL. Disclosures: Tiacci: Not applicable: Dr. Tiacci filed a patent for the clinical use of BRAF mutations as biomarkers of HCL. Other. Inghirami:OncoEthix SA: Research Funding. Falini:Not applicable: Dr. Falini filed a patent for the clinical use of BRAF mutations as biomarkers of HCL. Other.
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Rajala, Ulla. "PRE-COLONIAL LATIN COLONIES AND THE TRANSITION TO THE MID-REPUBLICAN PERIOD IN THE FALISCAN AREA AND SOUTH ETRURIA: ORIENTALIZING, ARCHAIC AND LATE ARCHAIC SETTLEMENT AND FUNERARY EVIDENCE FROM THE NEPI SURVEY." Papers of the British School at Rome 84 (September 20, 2016): 1–72. http://dx.doi.org/10.1017/s0068246216000015.
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This paper discusses the survey evidence from the Orientalizing and Archaic settlement and funerary sites at Nepi (ancient Nepet), one of the first Latin colonies outside Latium adiectum. The comparison of its pre-Roman, pre-colonial developments to the Roman patterns from the Nepi Survey Project and the trends from other Latin colonies in southern Etruria allows the examination of the local effects of Roman colonialism. The evidence shows that Nepi seemed to develop as an independent city state in the Orientalizing period, peaked in the Archaic period and weakened before the capture of Veii in 396bc, making it easier to defeat. Rural settlement all but disappeared afterwards with similar hiatus apparent at the sister colony at Sutri as well. In the third centurybcthe first few villas near the town appeared as a sign of the establishment of a Roman settlement pattern. The extensive ‘rural colonization’ at Nepi, similarly to Sutri and Cosa, started only in the second centurybcwhen all southern Etruria had entered a colonial phase and could develop alongside Rome. Thus, Latin colonization disrupted earlier patterns and the colonies appear to have been originally outposts set up to secure new territory.
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Garzon, R., S. Volinia, B. Falini, and C. M. Croce. "A unique microRNA signature associated with nucleophosmin mutations in normal karyotype acute myeloid leukemia." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 7015. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.7015.
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7015 Background: Nucleophosmin (NPM) mutations are present in about 30 to 50 % of the patients with normal karyotype acute myeloid leukemia (NK-AML). The mutant NPM protein shows aberrant cytoplasmic location and is frequently associated with FLT3 mutations. Little is know, however how NPM mutants promote leukemia. To obtain insights about the biology of NPM+ AML we investigated the expression of microRNAs in NK-AML patients characterized for NPM mutations. Methods: We studied 85 adult NK-AML patients characterized for NPM, FLT3 ITD and FLT3 D835 mutations using a miRNA microarray platform containing 345 mature and precursors miRNAs. Mutation analysis for NPM, FLT3 ITD and FLT3 D835 were carried out in most of the patients as previously described (Falini, Blood 2006). The distribution of the mutations were as follows: NPMc+ (54 patients), NPMc- (31), FLT3 ITD+ (27), FLT3 ITD-(51) and FLT3 D835+ (21) and FLT3 D835-(26). Data were analyzed after background subtraction and normalization with a set of housekeeping genes using Significance Analysis of Microarrays and Predictive Analysis of microarrays. The results were validated using miRNA q-RT-PCR. Results: We identified a strong miRNA signature that distinguishes NPMc+ cases with high accuracy and includes the up-regulation of miR-10a, miR-10b and several let-7 family members. Many of the down-regulated miRNAs including miR-134, miR-194, miR-204, miR-526 and miR-28 are predicted to target many HOX genes suggesting that NPM mutants may induce HOX genes through the down-modulation of miRNA regulators of these genes. The signatures associated with FLT3 mutations were not accurate to predict this abnormality. However, when we analyzed the subgroup of NPMc+ FLT3 ITD + cases a distinctive signature was found with respect to other NPMc+ FLT3 negative cases. Conclusions: A unique miRNA signature is associated with NPMc+ mutations in AML. FLT3 ITD and FLT3 D835 are not clearly associated to any characteristic miRNA signature when analyzed individually. However the subgroup of NPMc+ FLT3 ITD has a distinctive miRNA signature. This data provide with new insights about the pathogenesis of NPMc+ AML that could be exploited to generate novel therapeutic strategies for one of the most common mutations in AML. No significant financial relationships to disclose.
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Quentmeier, Hilmar, Maria P. Martelli, Wilhelm G. Dirks, Niccolo Bolli, Arcangelo Liso, Roderick A. F. MacLeod, Ildo Nicoletti, et al. "Exon-12 Nucleophosmin (NPM) Mutation and Aberrant Cytoplasmic Expression of NPM Protein in Leukemia Cell Line OCI-AML3." Blood 106, no. 11 (November 16, 2005): 2376. http://dx.doi.org/10.1182/blood.v106.11.2376.2376.
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Abstract Wild-type nucleophosmin (NPM) is a multifunctional protein shuttling between the nucleus and the cytoplasm. Chromosomal rearrangements leading to NPM fusion proteins occur in leukemias and lymphomas (e.g. with partners RARA, ALK). Recently, Falini et al. reported that 60% of acute myeloid leukemia (AML) patients with normal karyotype carry mutations at exon-12 of the NPM gene. This results in frame shifts that lead to alterations of the C-terminus of NPM resulting in the aberrant cytoplasmic localization of the mutated protein (NPMc+) (1). The effects of a mutationally altered protein on cellular functions like proliferation, differentiation or apoptosis, have often been revealed using immortalized cell lines that carry the mutation in question. Therefore, we screened a panel of 79 myeloid leukemia cell lines for presence of mutations - 4 bp insertions - at the exon-12 of the NPM gene. We performed polymerase chain reaction (PCR) analysis with fluorescent dye-labeled primers. For fragment size determination, the PCR products were mixed with dye-labeled size standards and separated by capillary electrophoresis. OCI-AML3 was the only cell line that expressed a signal in addition to and 4 bp larger than the wild-type NPM signal. Sequencing of the cloned NPM-mutated PCR product showed TCTG duplication at positions 956–959 of exon-12. This mutation was heterozygous and corresponded to the type that occurs in 77% of primary NPMc+ AMLs. OCI-AML3 cells have a hyperdiploid karyotype with 48(45–50)<2n>X/XY, +1, +5, +8, der(1)t(1;18)(p11;q11), i(5p),del(13)(q13q21), dup(17)(q21q25); sideline with r(Y)x1-2 and show the following immunoprofile: CD3−, CD4+, CD7−, CD8−, CD10−, CD13+, CD14−, CD15+, CD19−, CD30−, CD33−, CD34−, CD41+, CD42b−, CD68+, CD235a+, HLA-DR-. Especially the presence of myeloid markers and absence of CD34 is typical for NPMc+ cells (1). Furthermore, immunostaining with anti-NPM antibodies confirmed that the OCI-AML3 cells, like primary NPMc+ AML and in contrast to NPM wild-type cells, show cytoplasmic expression of NPM. Functional studies showed that the altered nucleo-cytoplasmic transport of NPM was nuclear export signalling-dependent and could be blocked by using the specific CRM1/exportin-1 inhibitor leptomycin B. In conclusion, cell line OCI-AML3 promises to be an important tool for studying the biological properties and response to new drugs of NPMc+ AML.