Academic literature on the topic 'Faecal occult blood test (FOBT)'

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Journal articles on the topic "Faecal occult blood test (FOBT)"

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Yong, Sook Kwin, Whee Sze Ong, Gerald Choon-Huat Koh, Richard Ming Chert Yeo, and Tam Cam Ha. "Colorectal cancer screening: Barriers to the faecal occult blood test (FOBT) and colonoscopy in Singapore." Proceedings of Singapore Healthcare 25, no. 4 (July 31, 2016): 207–14. http://dx.doi.org/10.1177/2010105816643554.

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Introduction: This study aims to identify the barriers to adopting faecal occult blood test (FOBT) and colonoscopy as colorectal cancer (CRC) screening methods among the eligible target population of Singapore. Materials and methods: This study was previously part of a randomised controlled trial reported elsewhere. Data was collected from Singapore residents aged 50 and above, via a household sample survey. The study recruited subjects who were aware of CRC screening methods, and interviewed them about the barriers to screening that they faced. Collected results on barriers to each screening method were analysed separately. Results: Out of the 343 subjects, 85 (24.8%) recruited knew about FOBT and/or colonoscopy. Most of the respondents (48.9%) cited not having symptoms as the reason for not using the FOBT. This is followed by inconvenience (31.1%), not having any family history of colon cancer (28.9%), lack of time (28.9%) and lack of reminders/recommendation (28.9%). Of the respondents who indicated not choosing colonoscopy as a screening method, more than one-half (54.8%) identified not having any symptoms as the main barrier for them, followed by not having any family history (38.7%) and having a healthy/low-risk lifestyle (29.0%). There was no difference between the reported barriers to each of the screening methods and the respondents’ dwelling types. Conclusions: Lack of knowledge, particularly the misconceptions of not having symptoms and being healthy, were identified as the main barriers to FOBT and colonoscopy as screening methods. Interventions to increase the uptake of CRC screening in this population should be tailored to address this misconception.
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Bond, Ashley D., Michael D. Burkitt, David Sawbridge, Bernard M. Corfe, and Chris S. Probert. "Correlation between Faecal Tumour M2 Pyruvate Kinase and Colonoscopy for the Detection of Adenomatous Neoplasia in a Secondary Care Cohort." Journal of Gastrointestinal and Liver Diseases 25, no. 1 (March 1, 2016): 71–77. http://dx.doi.org/10.15403/jgld.2014.1121.251.m2p.

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Background & Aims: Colorectal cancer screening programmes that target detection and excision of adenomatous colonic polyps have been shown to reduce colorectal cancer related mortality. Many screening programmes include an initial faecal occult blood test (FOBt) prior to colonoscopy. To refine the selection of patients for colonoscopy other faecal-based diagnostic tools have been proposed, including tumour M2-pyruvate kinase (tM2-PK). To determine whether tM2-PK quantification may have a role in diverse settings we have assessed the assay in a cohort of patients derived from both the England bowel cancer screening programme (BCSP) and symptomatic individuals presenting to secondary care. Method. Patients undergoing colonoscopy provided faecal samples prior to bowel preparation. Faecal tM2-PK concentrations were measured by ELISA. Sensitivity, specificity, positive predictive value, negative predictive value and ROC analyses were calculated. Results. Ninety-six patients returned faecal samples: 50 of these with adenomas and 7 with cancer. Median age was 68. Median faecal tM2-PK concentration was 3.8 U/mL for individuals without neoplastic findings at colonoscopy, 7.7 U/mL in those with adenomas and 24.4 U/mL in subjects with colorectal cancer (both, p=0.01). ROC analysis demonstrated an AUROC of 0.66 (sensitivity 72.4%, specificity 48.7%, positive predictive value 67.7%, negative predictive value 36.7%). Amongst BCSP patients with a prior positive FOBt faecal tM2-PK was more abundant (median 6.4 U/mL, p=0.03) and its diagnostic accuracy was greater (AUROC 0.82). Conclusion. Our findings confirm that faecal tM2-PK ELISA may have utility as an adjunct to FOBt in a screening context, but do not support its use in symptomatic patients. Abbreviations: BCSP: Bowel cancer screening programme; EMR: Endoscopic mucosal resection; FAP: Familial adenomatous polyposis; FOBt: Faecal occult blood testing; NHS: National Health Service; tM2-PK: tumour M2-pyruvate kinase.
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Lué, Alberto, Gonzalo Hijos, Carlos Sostres, Alba Perales, Mercedes Navarro, Maria Victoria Barra, Barbara Mascialino, et al. "The combination of quantitative faecal occult blood test and faecal calprotectin is a cost-effective strategy to avoid colonoscopies in symptomatic patients without relevant pathology." Therapeutic Advances in Gastroenterology 13 (January 2020): 175628482092078. http://dx.doi.org/10.1177/1756284820920786.

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Background: Faecal occult blood test (FOBT) has demonstrated effectiveness in colorectal cancer (CRC) screening. Faecal calprotectin (FC) has proven efficient for evaluating activity in inflammatory bowel disease (IBD), but its value in CRC detection is less established. Most symptomatic patients have benign pathologies, but still undergo colonoscopy in many settings. Aims: To evaluate the diagnostic accuracy and cost-effectiveness of the combination of FOBT plus FC in symptomatic patients. Methods: Patients who completed colonic investigations and returned stool samples, on which FOBT and FC were performed, were recruited prospectively. CRC, advanced adenoma, IBD and angiodysplasia were considered as relevant pathologies. Results: A total of 404 patients were included, of whom 87 (21.5%) had relevant pathologies. Sensitivity and specificity were 50.6% and 69.6% for FOBT, 78.2% and 54.4% for FC. Negative predictive value (NPV) was 90.1% for FC and 86.9% for FOBT. NPV for the combination of FOBT and FC was 94.1%, with a sensitivity and specificity of 88.5% and 50.3%. The area under ROC (receiver operator curve) (AUC) was 0.741 for FOBT, 0.736 for FC and 0.816 for the combination. The total cost for visits and procedures was €233,016 (€577/patient). Using a combination of FOBT and FC as pre-endoscopic tool allows colonoscopies to be reduced by 39.4%, reducing total costs by 20.5%. Conclusion: The combination of FOBT and FC has a better diagnostic accuracy compared with each test alone. Performing both tests before colonoscopy is a less costly and more effective strategy, reducing unnecessary procedures and complications.
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Pollack, Allan, Doreen Busingye, Jill Thistlethwaite, Suzanne Blogg, and Kendal Chidwick. "Characteristics of patients aged 50–74 years with a request for an immunochemical faecal occult blood test in the Australian general practice setting." Australian Health Review 46, no. 2 (February 28, 2022): 222–32. http://dx.doi.org/10.1071/ah21129.

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Objective To support improving participation in the National Bowel Cancer Screening Program (NBCSP), we aimed to identify Medicare-subsidised test requests for immunochemical faecal occult blood tests (FOBT) in Australian general practice for patients aged 50–74 years, eligible for the NBCSP, and describe sociodemographics, risk factors, indications and outcomes. Methods A cross-sectional study was conducted using de-identified data from 441 Australian general practice sites in the MedicineInsight database, recorded from 1 January 2018 to 31 December 2019. Results Of the 683 625 eligible patients, 45 771 (6.7%) had a record of a general practitioner (GP)-requested FOBT, either to aid diagnosis in symptomatic patients, or for screening; 144 986 (21.2%) patients had only an NBCSP FOBT. A diagnosis of polyps, gastrointestinal inflammatory condition or haemorrhoids, or a referral to a gastroenterologist or general surgeon, was more commonly recorded in the 6 months after a GP-requested FOBT than after an NBCSP FOBT. Uptake of NBCSP FOBTs was lower among those with obesity, high alcohol consumption and current smokers, who are at higher risk of bowel cancer. Conclusions This study describes the patient characteristics, reasons and outcomes associated with GP-requested FOBTs, identifies under-screened population sub-groups, and suggests involvement of GPs to improve participation in the NBCSP.
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Castiglione, G., G. Grazzini, G. Miccinesi, T. Rubeca, C. Sani, P. Turco, and M. Zappa. "Basic variables at different positivity thresholds of a quantitative immunochemical test for faecal occult blood." Journal of Medical Screening 9, no. 3 (September 1, 2002): 99–103. http://dx.doi.org/10.1136/jms.9.3.99.

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OBJECTIVES: Screening by faecal occult blood testing (FOBT) is effective in decreasing mortality and incidence of colorectal cancer (CRC). Immunochemical tests have proved to be more cost effective than guaiac FOBTs. The latex agglutination test (LAT) has the advantage of being a fully automated, quantitative test. The aim of this study is to interpret the overall experience with LAT according to different positivity thresholds. SETTING: A population based screening programme is currently running involving subjects aged 50–70, invited every 2 years to have an FOBT. LAT is the standard screening test and has a positivity threshold for further diagnostic tests of 100 ng haemoglobin/ml of sample solution. METHODS: Positivity rates, detection rates for CRC high risk adenomas, and positive predictive values for CRC, high risk adenomas, and low risk adenomas were calculated for several positivity thresholds. RESULTS: 19 132 attendances at screening were recorded (11 774 at first screening, 7358 at subsequent screenings). Progressively increasing the positivity threshold from 100 to 200 ng/ml showed (a) a decrease in positivity rate; (b) a decrease in detection rates for CRC or high risk adenomas; (c) an increase in positive predictive values for cancer; (d) an increase in positive predictive value for high risk adenomas. CONCLUSIONS: Increasing the positivity threshold of the LAT reduces recall rate and improves positive predictive value for cancer or high risk adenomas but substantially decreases the detection rate of CRC and high risk adenomas. For this reason increasing the positivity cut off for LATs is not advisable. On the other hand decreasing the positivity threshold would increase recall rate and sensitivity of screening. Careful evaluation of sensitivity of the quantitative results of the LAT for interval cancers is needed to definitively assess the optimal positivity threshold for LATs in population based screening programmes.
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Grazzini, Grazia, Stefano Ciatto, Cesare Cislaghi, Guido Castiglione, Manuele Falcone, Paola Mantellini, and Marco Zappa. "Cost evaluation in a colorectal cancer screening programme by faecal occult blood test in the District of Florence." Journal of Medical Screening 15, no. 4 (December 2008): 175–81. http://dx.doi.org/10.1258/jms.2008.008032.

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Objectives To evaluate the direct costs of first and repeat colorectal cancer screening by immunochemical faecal occult blood testing (I-FOBT). Methods Florence district residents aged 50–70 were invited to undergo one-time I-FOBT every two years. Full colonoscopy was recommended for FOBT-positive subjects. Direct cost analysis was carried out separately for the first and repeat screening. All relevant resources consumed by the programme were calculated. Results Among 25,428 or 62,369 subjects invited to the first or repeat screening, respectively, the corresponding participation rate was 47.8% or 52.3%, and the positivity rate was 4.4% and 3.3%. Corresponding detection rates and positive predictive values for cancer and advanced adenoma were 11.3% or 8.9% and 32.4% or 32.8%, respectively. The assessment phase accounted for the major cost, as compared with recruitment and screening. All cost indicators were slightly higher in the first screening compared with repeat screening. Cost per cancer and advanced adenoma detected was similar in the first or repeat screening. A higher than observed participation rate would have substantially reduced screening cost. Conclusion Analysis of I-FOBT-organized population-based screening cost demonstrates lower cost at repeat compared with first screening and provides reference for decision-making in screening implementation.
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Brown, Louise F., and Callum G. Fraser. "Effect of delay in sampling on haemoglobin determined by faecal immunochemical tests." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 45, no. 6 (September 9, 2008): 604–5. http://dx.doi.org/10.1258/acb.2008.008024.

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Background Faeces must be sampled directly onto guaiac-based faecal occult blood test (FOBT) cards since analysis of specimens collected in traditional faeces containers is inappropriate because degradation of haemoglobin continues after faeces have been passed. Newer faecal immunochemical tests (FIT) are replacing FOBT, but it is likely that the practice of obtaining specimens in traditional faeces collection containers for later analysis will continue. The aim of this study was to assess the effect of delay in stool sampling on FIT. Methods Five specimens of faeces from healthy volunteers, all qualitatively FIT negative, were supplemented with whole blood haemolysate to three different FIT positive concentrations. Each sample was analysed daily after 1–14 days delay using a quantitative latex immunoturbidimetric-based FIT and also after five and ten days delay using a qualitative FIT. Results Haemoglobin concentrations fell each day, the rate being generally proportional to the original haemoglobin concentration. After eight days delay, no sample had a haemoglobin concentration >100 ng/mL and, after nine days, no sample had a haemoglobin concentration >50 ng/mL. After five days delay, five of the 15 supplemented faeces with initially positive qualitative FIT had negative FIT; after 10 days, none had positive FIT. Conclusion False-negative results will occur if sampling of fresh faeces into or onto FIT collection devices is delayed. Laboratories that undertake FIT analyses on faeces collected into traditional containers are likely to miss significant neoplasia. FIT collection devices must be used for sampling fresh faeces.
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Lecis, P., S. Mancuso, G. Bertiato, E. Galliani, F. Soppelsa, R. Mel, R. Schiavon, A. Quaranta, S. Di Camillo, and B. Germanà. "Colorectal cancer screening with immunochemical faecal occult blood test (FOBT): Intermediate results with high acceptance rate." Digestive and Liver Disease 38 (April 2006): S113. http://dx.doi.org/10.1016/s1590-8658(06)80302-6.

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Cole, S. R., G. Young, D. Byrne, J. Guy, and J. Morcom. "Participation in screening for colorectal cancer based on a faecal occult blood test is improved by endorsement by the primary care practitioner." Journal of Medical Screening 9, no. 4 (December 1, 2002): 147–52. http://dx.doi.org/10.1136/jms.9.4.147.

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OBJECTIVES: To investigate the influence of general practitioner (GP) endorsement on participation in screening for colorectal cancer based on a faecal occult blood test (FOBT). SETTING: South Australian residents (n=2400), in 1999, aged >50 years. METHODS: Random selection of three groups (GP1, GP2, GP3) from two general practices and of one group (ER) from the federal electoral roll; n=600 per group. Without previous communication or publicity, subjects were posted an offer of screening by immunochemical FOBT. The GP1 and ER groups were invited without indication that their GP was involved; GP2 received an invitation indicating support from the practice; and GP3 received an invitation on practice letterhead and signed by a practice partner. A reminder was posted at 6 weeks. Participation was defined as return of correctly completed FOBT sample cards within 12 weeks. RESULTS: Participation rates were: GP1 192/600 (32.0%), GP2 228/600 (38.0%), and GP3 244/600 (40.7%); &khgr;2=10.2, p=0.006. Both GP2 and GP3 differed significantly from GP1 (odds ratio (OR) 0.77, 95% confidence interval (95% CI) 0.60 to 0.98 and relative risk (RR)=0.69, 95% CI 0.54 to 0.87 respectively). ER (193/600 (32.2%)) and GP1 were not significantly different. Age but not sex was significantly associated with participation. Overall test positivity rate was 4.6%; five malignancies were found in the 918 who performed FOBT. CONCLUSIONS: Association of a GP of recent contact with a screening offer in the form of a personalised letter of invitation achieves better participation than does the same letter from a centralised screening unit that does not mention the GP. Thus, GP enhanced participation is achievable without their actual involvement. Additional strategies are needed to further improve participation.
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George, AT, S. Aggarwal, M. Dube, A. Menon, M. Vogler, R. Logan, and A. Field. "PWE-282 Implications of a ‘false negative’ faecal occult blood test (FOBT) – results from a multicentre study." Gut 64, Suppl 1 (June 2015): A335.3—A336. http://dx.doi.org/10.1136/gutjnl-2015-309861.728.

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Dissertations / Theses on the topic "Faecal occult blood test (FOBT)"

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Stevenson, Christopher Eric, and Chris Stevenson@aihw gov au. "A microsimulation study of the benefits and costs of screening for colorectal cancer." The Australian National University. National Centre for Epidemiology and Population Health, 2001. http://thesis.anu.edu.au./public/adt-ANU20040611.162207.

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This thesis examines the benefits and costs of screening for colorectal cancer in the context of an organised population screening programme. It uses microsimulation modelling to derive an optimally cost-effective screening protocol for various combinations of the available screening tests. ¶ First a mathematical model for the natural history of colorectal cancer is derived, based on analyses of Australian population and hospital-based cancer registries combined with data from published studies. Then a model for population based screening is derived based mainly on data from published screening studies, including the four major published randomised controlled trials of faecal occult blood test (FOBT) screening. These two models are used to simulate the application of a screening programme to the Australian population. The simulations are applied to a period of 40 years following 1990 (the study’s base year), with both costs and benefits discounted back to the base year at an annual rate of 3%.¶ The models are applied to simulating a population screening programme based on FOBT with a colonoscopy follow up of positive tests. This simulation suggests that the optimal application of such a programme would be to offer annual screening to people aged 50 to 84 years. Such a programme would lead to a cumulative fall in years of life lost to colorectal cancer (YLL) of 28.5% at a cost per year of life saved (YLS) of $8,987. These costs and benefits are consistent with those arising from other currently funded health interventions. They are also consistent with the cost per YLS which Australian governments appear willing to pay for health interventions when justified on the basis of cost-effectiveness. The fall in colorectal cancer deaths from this screening programme should be first detectable by a national monitoring system after around three years of screening. However the full benefits from screening would not be realised before around 30 years of screening.¶ These simulations are based on the standard guaiac FOBT, but the results suggest that significant cost-effective gains could be made by using the newer immunochemical FOBT. Further cost-effect gains could be made by offering sigmoidoscopy every five years in addition to annual FOBT.¶ The models are then applied to simulating population screening programmes using colonoscopy and sigmoidoscopy as primary screening tools. Offering colonoscopy every ten years to all people aged from 45 to 85 leads to an overall fall in cumulative YLL of 37.6%, at a cost of $15,585 per YLS. Offering sigmoidoscopy every three years to all people aged 40 to 85 leads to an overall fall in cumulative YLL of 29.1%, at a cost of $4,862 per YLS. Both of these cost and benefit results are also consistent with the cost per YLS which Australian governments appear willing to pay. The fall in deaths with colonoscopy screening would also be detectable after three years of screening but the fall with sigmoidoscopy screening would not be detectable until after six years of screening. Sigmoidoscopy would need around 35 years of screening to reach its potential gains while colonoscopy screening would not reach its full potential during the 40 year screening period.¶ Finally the models are applied to targeting people at higher risk of cancer. The results show that offering colonoscopy every five years to people at higher risk because of a family history of colorectal cancer is a cost-effective addition to the annual FOBT screening programme.¶ An earlier version of chapter two of this thesis has been published as Stevenson CE 1995. Statistical models for cancer screening. Statistical Methods in Medical Research; 4: 19–23.¶ An expanded version of chapter two, along with parts of chapter one, has been published as Stevenson CE 1998. Models of screening. In: Encyclopedia of Biostatistics. Armitage P, Colton T, eds. John Wiley and Sons Ltd, pp 3999–4022.
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Walker, Andrew. "An economic evaluation of mass population screening for colorectal cancer using a faecal occult blood test." Thesis, University of Nottingham, 1993. http://eprints.nottingham.ac.uk/11302/.

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Cancer of the colon and rectum is a major cause of ill-health. Options for reducing the burden of the disease include primary prevention, screening for early stage asymptomatic disease and improvements in the treatment of symptomatic disease. If the policy objective is to make a major impact on mortality from the disease then screening appears to be the only technically feasible option. One indication of asymptomatic colorectal cancer is small quantities of blood mixed with faeces. Screening tests capable of detecting bleeding are currently being evaluated in clinical trials. Interim measures of the costs and disease yield of a screening programme using a faecal occult blood test imply that screening may offer good value for money but only if the intended mortality reduction from the disease is realised. There are various ways of 'fine-tuning' the screening programme to improve the balance of costs and benefits; information for making choices regarding important parameters such as the age range of the population to be offered screening are presented. Alternative screening tests are also evaluated and the results presented in terms of the cost-yield trade-off. The policy implications of the evaluation must be qualified at this stage since no proof of mortality reduction will be available until the conclusion of the ongoing trial. Nevertheless, under various assumptions about the impact of screening, the option appears to be an efficient way of reducing the health 'costs' of colorectal cancer.
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Fong, Yuen, and 方圓. "A systematic review of factors influencing the uptake of screening for colorectal cancer using a faecal occult blood test." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193837.

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Background Colorectal cancer (CRC) is one of the most common cancers with high morbidity and mortality among both genders and yet it carries a better prognosis when detected early. Colorectal cancer screening using faecal occult blood test (FOBT) is proven to be cost-effective, however worldwide FOBT uptake rate is suboptimal which directly affects the cost-effectiveness of the screening program. Identifying those factors that influence the uptake of colorectal cancer screening using FOBT will allow implementation of relevant measures when planning a population based screening program. Methods A structured electronic search using PubMed and Medline was conducted in order to identify studies that included factors influencing the uptake of CRC screening by using FOBT. Qualities of included studies were assessed by quality assessment checklist STROBE. Results Factors that contributed to the low uptake rate of CRC screening by FOBT were identified and summarized. They were broadly divided into 3 groups. Demographic factors: age, gender, social economic status, insurance status and education, for ethnicity, employment status and obesity further studies in the future may be needed. Subject factors: subject’s attitudes and knowledge towards CRC screening, type of FOBT screening, health concerned behavior, frequency of clinical visit and physiciancomment. Provider factors: health care system factor and physicians’ factors. Conclusion Different factors, in particular those factors that were associated with low FOBT uptake rate in CRC screening, were reviewed and summarized in this paper. With the continuous effort from worldwide as well as local investigators, timely measures can be implemented to tackle this deathly disease and to ensure cost effectiveness of a screening program.
published_or_final_version
Public Health
Master
Master of Public Health
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Hughes, Karen Leigh. "Repeat adherence to colorectal cancer screening utilising faecal occult blood testing : a community-based approach in a rural setting." Thesis, Queensland University of Technology, 2006. https://eprints.qut.edu.au/16416/1/Karen_Hughes_Thesis.pdf.

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In Australia, colorectal cancer (CRC) is the most common registrable cancer affecting both men and women, and the third most common cause of cancer deaths. Clinical data from randomised, controlled trials indicate that population-based screening utilising the faecal occult blood test (FOBT) can reduce mortality from this disease. However, high adherence rates with repeated testing are required to secure these outcomes. This study examines repeat adherence with FOBT screening in a rural community two years after a first screening round was conducted. Patients, aged 50 to 74 years, registered with four local general practices were mailed a FOBT kit with a letter of invitation from their general practitioner. Following the intervention, 119 telephone interviews were conducted with adherers and non-adherers to examine knowledge and attitudes related to screening. Compliance with screening was recorded and compared with first round-data. Participation in the screening program was modest. Of the 3,406 participants eligible for both screening rounds, 34.1% and 34.7% participated in rounds 1 and 2, respectively. A majority of participants (56.8%) did not adhere to either screening, a quarter (25.7%) participated in both rounds, and 17.5% participated in one of the two rounds. First-round adherence was the strongest predictor of second-round adherence (OR=16.29; 95% CI: 13.58, 19.53) with 75.2% of first-round adherers completing a FOBT in round 2. Females were also more likely to adhere in both rounds, although the difference between females and males decreased across rounds. Knowledge and attitudes differed between adherers and non-adherers and are discussed within the context of the major findings. Results from this trial indicate that achieving high levels of compliance in a national screening program will be challenging. Strategies to increase repeat adherence are suggested.
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Hughes, Karen Leigh. "Repeat adherence to colorectal cancer screening utilising faecal occult blood testing : a community-based approach in a rural setting." Queensland University of Technology, 2006. http://eprints.qut.edu.au/16416/.

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In Australia, colorectal cancer (CRC) is the most common registrable cancer affecting both men and women, and the third most common cause of cancer deaths. Clinical data from randomised, controlled trials indicate that population-based screening utilising the faecal occult blood test (FOBT) can reduce mortality from this disease. However, high adherence rates with repeated testing are required to secure these outcomes. This study examines repeat adherence with FOBT screening in a rural community two years after a first screening round was conducted. Patients, aged 50 to 74 years, registered with four local general practices were mailed a FOBT kit with a letter of invitation from their general practitioner. Following the intervention, 119 telephone interviews were conducted with adherers and non-adherers to examine knowledge and attitudes related to screening. Compliance with screening was recorded and compared with first round-data. Participation in the screening program was modest. Of the 3,406 participants eligible for both screening rounds, 34.1% and 34.7% participated in rounds 1 and 2, respectively. A majority of participants (56.8%) did not adhere to either screening, a quarter (25.7%) participated in both rounds, and 17.5% participated in one of the two rounds. First-round adherence was the strongest predictor of second-round adherence (OR=16.29; 95% CI: 13.58, 19.53) with 75.2% of first-round adherers completing a FOBT in round 2. Females were also more likely to adhere in both rounds, although the difference between females and males decreased across rounds. Knowledge and attitudes differed between adherers and non-adherers and are discussed within the context of the major findings. Results from this trial indicate that achieving high levels of compliance in a national screening program will be challenging. Strategies to increase repeat adherence are suggested.
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Hewitson, Paul James. "A Primary Care-based intervention to improve participation in the NHS Bowel Cancer Screening Programme." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:eb7dcbc4-a1c4-4c37-9dc1-6a74f99edcbf.

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Background: Currently, participation in the NHS Bowel Cancer Screening Programme (NHSBCSP) is poor, with around half of all people invited returning their (FOBT) kits. The research programme aimed to investigate whether a general practitioner’s (GP) letter encouraging participation and a detailed leaflet explaining how to complete the (FOBT) included with the invitation materials would improve uptake. Methods: The research programme was divided into three phases which were designed to sequentially develop and evaluate the two interventions. The initial and second phases developed and refined the two interventions and the trial outcome measures with previous participants and stakeholder representatives. The final phase was a randomised 2x2 factorial trial conducted with people invited to screening in October 2009. Participants were randomised to either a GP’s endorsement letter and/or a detailed procedural leaflet with their FOBT kit. The primary outcome was verified participation in the NHSBCSP. Questionnaires were also used to evaluate participant perceptions of CRC screening and GPs views on involvement with the NHSBCSP. Results: The factorial trial demonstrated both the GP’s endorsement letter and the detailed procedural leaflet increased participation in the NHSBCSP. In the intention-to-treat analysis, participation improved by 6% for the detailed procedural leaflet and 5.8% for the GP endorsement letter 20 weeks after receipt of the FOBT kit. The random effects logistic regression model confirmed that there was no important interaction between the two interventions, and estimated an adjusted rate ratio of 1.11 (P=0.038) for the GP’s letter and 1.12 (P=0.029) for the leaflet. The per protocol analysis indicated that the insertion of an electronic GP’s signature on the endorsement letter was associated with increased participation (P=0.039). Conclusions: Including both an endorsement letter from each patient’s GP and a detailed procedural leaflet could increase participation in the NHSBCSP by around 10%, a relative improvement of 20% on the current participation rate. Both interventions were well-received by participants and there was minimal impact on GP workload.
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Stevenson, Christopher Eric. "A microsimulation study of the benefits and costs of screening for colorectal cancer." Phd thesis, 2001. http://hdl.handle.net/1885/48198.

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This thesis examines the benefits and costs of screening for colorectal cancer in the context of an organised population screening programme. It uses microsimulation modelling to derive an optimally cost-effective screening protocol for various combinations of the available screening tests. ¶ First a mathematical model for the natural history of colorectal cancer is derived, based on analyses of Australian population and hospital-based cancer registries combined with data from published studies. Then a model for population based screening is derived based mainly on data from published screening studies, including the four major published randomised controlled trials of faecal occult blood test (FOBT) screening. These two models are used to simulate the application of a screening programme to the Australian population. The simulations are applied to a period of 40 years following 1990 (the study’s base year), with both costs and benefits discounted back to the base year at an annual rate of 3%. ¶ ...
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Huang, Kuan-Jen, and 黃冠蓁. "Disease prevention values and self-efficacy regarding faecal occult blood test (FOBT) related to colorectal cancer screening behavior and intention – a population based case-control study in central Taiwan." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/55627541899298881428.

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碩士
中山醫學大學
公共衛生學系碩士班
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Objectives: The aim of this study in individual level was to identify the relationships between independent variables [(1) disease prevention related values, (2) cues to action and (3) self-efficacy regarding Faecal Occult Blood Test (FOBT)] and outcome variables (FOBT behavior and intention to future FOBT) in a community population. As for environmental level, this study used multilevel analyses to specify the relationships between outcome variables (FOBT screening behavior and intention to future FOBT) and independent variables (Education level and income status of townships). Methods: A community-based case-control study was conducted by cross-sectional household survey (questionnaire). According to FOBT screening behaviors in 2015, we divided four groups as (1) regular screenees (ever-screenees and completing FOBT in 2015, as control group), (2) irregular screenees (ever-screenees but not completing FOBT, as case A), (3) first screenees (never-screenees and completing FOBT, as case B), (4) never screenees (never-screenees and not completing FOBT, as case C). Participation rates of each group were 46.00% (control group), 41.92% (case A), 39.53% (case B), 36.48% (case C), respectively. A total sample of 814 participants, those aged 50 to 74 lived in Chunghua County, was collected during September, 2015 to January, 2016. Results: Both individual level models were adjusted for gender, age, education, job, income, and personal disease history. For FOBT behavior: (1) disease prevention value of first and never screenees were lower than regular screenees (Odd ration (OR) =0.96 and 0.94, respectively); (2) self-efficacy in irregular, first screenees, and never screenees were lower than regular screenees (OR=0.89, 0.86 and 0.72, respectively). For intention to future FOBT: (1) those who perceived higher disease prevention value showed higher intention to future FOBT; (2) those who reported higher self-efficacy also showed higher intention to future FOBT; (3) never screenees’ self-efficacy were lower than regular screenees. Cues to actions only show significant relationship with the intention to future FOBT: those who received more cues showed higher intention to future FOBT. For environmental level results, this study discovered that those lived in a higher education level township were more likely to possess never screening behavior (compared to regular screening behavior). The income status of townships did not show significant relationship with FOBT behavior. Neither the education level nor the income status of townships has shown a significant relationship with the intention to future FOBT. Conclusions: In individual level, disease prevention values and self-efficacy were significantly positive associated with FOBT behavior and intention. Future intervention and health education program could consider these factors to improve FOBT behavior. In environment level, the education level of townships has found to be a factor of FOBT behavior, but not related to intention. The income status of townships, however, did not show any relation with neither FOBT behavior nor the intention to future FOBT. Our study suggests that organized screening in Chunghua County could successfully reduce the possible health inequity caused by different income status of townships.
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9

Khan, Abdul Haseeb. "Patterns of faecal occult blood test and colonoscopy use in Portugal." Master's thesis, 2018. https://hdl.handle.net/10216/116369.

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Khan, Abdul Haseeb. "Patterns of faecal occult blood test and colonoscopy use in Portugal." Dissertação, 2018. https://repositorio-aberto.up.pt/handle/10216/116369.

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Book chapters on the topic "Faecal occult blood test (FOBT)"

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Hardcastle, J. D., W. M. Thomas, and G. Pye. "A Comparison of an Immunological and a Chemical Faecal Occult Blood Test in Symptomatic Patients." In Updates in Colo-Proctology, 245. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-51680-1_45.

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Fennerty, M. Brian. "Positive Fecal Occult Blood Test (FOBT)." In Decision Making in Medicine, 216–17. Elsevier, 2010. http://dx.doi.org/10.1016/b978-0-323-04107-2.50081-8.

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Wu, Dongfeng, and Adriana Prez. "Modelling and Inference in Screening: Exemplification with the Faecal Occult Blood Test." In Colorectal Cancer - From Prevention to Patient Care. InTech, 2012. http://dx.doi.org/10.5772/29894.

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Conference papers on the topic "Faecal occult blood test (FOBT)"

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Rodríguez Martín, L., DJ Matias, L. Monteserín Ron, S. Vivas Alegre, R. Díez Rodríguez, C. Villar Lucas, R. Quiñones Castro, MI Fernández, E. Fernández Morán, and F. Jorquera Plaza. "UTILITY OF FAECAL OCCULT BLOOD TEST (FOBT) OUT OF COLORECTAL CANCER SCREENING PROGRAMME." In ESGE Days 2018 accepted abstracts. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1637310.

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Ealey, Jamila, Cathy D. Meade, Clement K. Gwede, Gwendolyn Quinn, Rania Abdulla, Susan Vadaparampil, Ji-Hyun Lee, et al. "Abstract A9: Patients’ perspectives on immunochemical fecal occult blood test (I-FOBT or FIT): Not your father's FOBT." In Abstracts: AACR International Conference on the Science of Cancer Health Disparities‐‐ Sep 18-Sep 21, 2011; Washington, DC. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1055-9965.disp-11-a9.

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Bandi, Priti, Vilma Cokkinides, Robert A. Smith, and Ahmedin Jemal. "Abstract B96: Trends in colorectal cancer screening with home-based fecal occult blood test (FOBT) in adults aged 50–64 years, 2000–2008." In Abstracts: AACR International Conference on the Science of Cancer Health Disparities‐‐ Sep 18-Sep 21, 2011; Washington, DC. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1055-9965.disp-11-b96.

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Tardieu, E., S. Manfredi, V. Cottet, and J. Faivre. "UP TO WHAT AGE PROPOSE MASS SCREENING FOR COLORECTAL CANCER BY FAECAL OCCULT BLOOD TEST? ANALYSIS OF A COHORT IN A WELL-DEFINED POPULATION." In ESGE Days 2019. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1681624.

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