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Thomas, Robyn. "Appraisal in the gendered organisation : the experience of women academics." Thesis, University of South Wales, 1997. https://pure.southwales.ac.uk/en/studentthesis/appraisal-in-the-gendered-organisation(6c27a71b-f07a-46ee-9354-c5e0fd992d8e).html.
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This thesis investigates women academics' experiences of the gendered university culture, during a period of rapid change in the management of higher education and the academic profession. The research draws on a Foucauldian feminist methodology to understand how, and in what ways, the dominant discourses of the university culture constitute women academics' identities. In particular, the research questions the nature of the gender relations emerging as a result of the introduction of the discourses of 'new public management'. The research examines the ways in which these new discourses are promoted through a range of disciplinary technologies, including academic appraisal, and the impact this has on women academics' professional roles and identities. The empirical work is based on three university case studies, from both the 'old' and 'new' university sectors. In each case study, the women academics tell of their experiences of the gendered university culture, and their perceptions of the appraisal process. The findings suggest that the recent changes in the management of universities have reinforced and strengthened the masculine discourses of the gendered academy. The opportunities for women to exploit the discursive spaces arising from the recent unseating of the traditional discourses of the academy have been marginal. Through the adoption of a Foucauldian feminist methodology, this research has enabled women academics to have a voice in the shaping of knowledge about university organisations and management. In doing so, the research contributes to the understanding of gendered university cultures and the constitution of individual subjectivities, as well as, in the wider context, the gendered nature of organisations and organisational theory.
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Khotavivattana, Tanatorn. "¹⁸F-labelling of new chemotypes for drug discovery." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:d4e8c8fd-f07d-44c3-b95b-5e7ad4127dde.
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In this thesis, the 18F-labelling of new "chemotypes" will be described with the aim of application in pharmaceutically interesting targets. In Chapter 1, a general introduction to the effect of fluorine substituents on molecular properties and reactivity is provided. This includes the application of organofluorine in both medicinal chemistry and positron emission tomography. Chapter 2 describes a novel silver-mediated 18F-labelling of Ar-SCF3, Ar OCF3 and Ar-OCF2H, including [18F]Riluzole, the 18F labelled version of a drug for treatment of amyotrophic lateral sclerosis (ALS). This work demonstrates that AgOTf can induce halogen exchange nucleophilic 18F-fluorination under mild reaction conditions with a wide range of substrates. In addition, the 18F-labelled Ar-SCF3 substrate is further transformed into the [18F]Umemoto reagent in a single step. The Umemoto reagent has been extensively used for electrophilic trifluoromethylation of various functional groups. Therefore the labelling of this reagent could potentially expand the radiochemical space available for PET applications. To augment the utility of this reagent, we developed a late-stage stereoselective trifluoromethylation-thiocyclisation of alkenes using electrophilic trifluoromethylating reagents such as Umemoto reagent or Togni reagent, which will be discussed in Chapter 3. In this process, thiourea acts as both S-nucleophile and CF3 radical initiator; therefore no metal or photoredox catalyst is required. The reaction affords novel trifluoromethylated 2-amino-thiazolines and 2-amino-thiazines, important scaffolds in the development of aspartate beta-secretase enzyme (BACE-1) inhibitors, a therapeutic target for Alzheimer's disease. Chapter 4 investigates the 18F-labelling of a,a-difluoro-a-aryloxyacetic acid, a class of substrate that can serve as a versatile intermediate which can undergo various decarboxylative functionalisation reactions to afford a wide range of novel 18F labelled a fluorinated aryl ethers. Finally, Chapter 5 gives full experimental procedures and characterisation data for all compounds.
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Lalic, Tatjana. "Synaptic transmission of hippocampal mossy fibres in health and disease." Thesis, University of Oxford, 2009. http://ora.ox.ac.uk/objects/uuid:cb37e4ad-f00a-4fb5-b4b4-5f8a55c3c64c.
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Dentate microcircuitry is thought to be involved in filtering, integrating, and relaying extrinsic hippocampal inputs to the hippocampus proper, which contributes to memory formation and retrieval. The axons of granule cells are called mossy fibres (MFs), and contain multiple terminal types that form characteristic synaptic connections with their postsynaptic targets. This diversity of presynaptic release sites that exists on the same MF provides an extremely interesting axonal type to study the organizing principles of presynaptic release regulation. A remarkable set of neurotransmitters and receptors present at the MF synaptic complex allow diverse computational modification of information from the dentate gyrus to the hippocampus. There are several types of glutamate receptors expressed at MF, such as group II/III mGluRs and kainate receptors (KARs). Presynaptic KARs modulate transmission at MF-CA3 pyramidal cell synapses; however, it is not known whether presynaptic KARs affect other synapses made by MFs. The aim of the first part of this thesis was to establish the principles of synapse-specific actions of presynaptic KARs in MFs. Combining electrophysiology and calcium imaging, this study provides compelling evidence that presynaptic KARs and Ca2+ stores can be activated by glutamate release from a single action potential in a single MF axon. This contributes to short-term, use-dependent facilitation of presynaptic Ca2+ entry and glutamate release exclusively at MF-CA3 pyramidal cell synaps, but not at other MF synapses, on hilar mossy cells or interneurons. Thus, our findings indicate that the presynaptic KARs, coupled with intracellular stores, exist in a synapse-specific autoreceptor mechanism. Activation of KARs strengthened MF-CA3 pyramidal cell synapses by increasing the Ca2+ influx at giant boutons, which might also contribute to the KAR-dependent hyper-excitability of the MF circuitry related to the mechanisms of temporal lobe epilepsy (TLE). This makes KARs good potential targets for therapies in CNS disorders such as epilepsy and other neurological and psychiatric disorders. The second part of this thesis was to explore the actions on the hippocampus of purified antibodies from a limbic encephalitis (LE) patient. LE is a CNS disease characterized by subacute onset of memory loss and temporal lobe seizures. The serum of these patients strongly labels MFs apparently co-localizing with the VGKC. The patients improve with immunotherapies that reduce the VGKC antibody levels in the serum, thus, strongly suggesting that these antibodies cause the condition. We found that LE serum IgGs enhance CA3 pyramidal cell excitability by blocking α-DTX sensitive VGKCs, which results in the increased release of glutamate. This, in turn, strengthens and desynchronizes MF and CA3 pyramidal cells synaptic transmission. However, these effects were occluded by α-DTX, a Kv1.1, Kv1.2 and Kv1.6 antagonist which, when applied alone, mimicked the action of the LE IgG, suggesting that they may share similar mechanisms of action. In contrast serum taken from healthy control patients had no significant effect under same recording conditions. Thus, this study provides the first evidence that the LE IgG functionally affects VGKC containing Kv1.1, Kv1.2 and/or Kv1.6 at both presynaptic MF axon terminals as well as the postsynaptic somatodendritic domain of CA3 pyramidal cells. Whatever defines the exact nature of LE IgG action, our results suggest that drugs acting specifically as openers of VGKC might help to protect the hippocampus from immune-mediated damage. In conclusion my data is consistent with the increasingly documented idea that MFs play a critical role in regulating the excitability of the hippocampal circuits and the dysfunction of MF transmission profoundly impairs hippocampal function.
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Chen, Yiping. "Word recognition and reading in Chinese." Thesis, University of Oxford, 1993. http://ora.ox.ac.uk/objects/uuid:8f034ff4-f07c-459b-95f7-4b0a72e07c45.
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Finally, the present thesis develops an analytic account of word recognition and reading in Chinese. Implications are drawn for both experimental studies of normal reading and neuropsychological studies of dyslexia in Chinese.
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Stovold, Caroline P. "An ion-binding approach to asymmetric allylation reactions." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:1dc96ffb-f079-4b7a-847e-5d2fb792caf9.
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Ion-binding organocatalysis is an emerging field that has the potential to control the stereochemical outcome of any transformation that goes via charged intermediates. The aim of this project was to explore how this concept could be applied to an asymmetric allylation reaction. Chapter 2 of this thesis discusses anion-binding catalysis and investigates a chiral cooperative thiourea catalyst that could bind to fluoride to control allylation using an allylsilane. Optimization using a non-chiral thiourea (Schreiner’s catalyst) demonstrated that the reaction proceeded in high yield with TBAT onto an N-benzoylhydrazone. A chiral cooperative thiourea catalyst library was then synthesized but unfortunately, although the allylation using these catalysts proceeded in excellent yield, the product was isolated as the racemate (Scheme 1). Scheme 1: Anion-binding catalysis gave allylated products in high yields but gave no stereocontrol. Chapter 3 examines a chiral quaternary ammonium fluoride as an example of chiral cation-directed catalysis. We hypothesized that an allylsilane activated by fluoride would generate an allyl anion species that would associate with the chiral quaternary ammonium cation through electrostatic interactions. Extensive optimization found that the allylation reaction proceeded in good yield in chloroform at reflux with N-benzoylhydrazones. Different fluoride catalysts were prepared using an ion-exchange resin, and cinchonidine-derived catalysts performed the best. This methodology was extended to a phase-transfer catalyzed process, where solid cesium fluoride exchanged with chloride in situ, removing the need to synthesize and isolate ammonium fluoride catalysts (Scheme 2). Scheme 2: Cation-directed asymmetric allylation. In Chapter 4 cation-directed asymmetric catalysis was extended to an intramolecular allylation reaction. Substrate synthesis was attempted by cross metathesis but the reaction was capricious and yields were low. Intramolecular allylation with these materials gave promising results (Scheme 3) but a lack of material prevented optimization. Scheme 3: Intramolecular allylation results.
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Tan, Tiong Kit. "Development of viral vectors for passive immunisation against influenza." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:54fd7396-f09a-46e5-952e-95a1f5449326.
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Seasonal influenza is a major global health threat causing more than 500,000 deaths annually. Pandemic influenza can arise through antigenic shift, or when novel influenza strains escape from animal reservoirs, and can affect a large geographical area leading to a large number of deaths. Neither prior infection, nor current vaccines, provide lasting protection due to the rapid antigenic evolution of influenza virus. The discovery of broadly neutralising antibodies (bnAbs) against influenza has opened the possibility of passive immunisation, which could provide protection against multiple influenza strains. Passive immunisation by parenteral administration of purified antibody is challenging, hindered by high antibody production costs and the short half-life of antibody in the circulation leading to relatively transient protection; however the use of viral vectors to deliver bnAbs can begin to address these limitations. Studies presented in this thesis investigated the feasibility of a novel, lung-targeting lentiviral vector pseudotyped with the fusion (F) and haemagglutinin-neuraminidase (HN) coat proteins from Sendai virus (rSIV.F/HN) as a gene transfer agent for bnAb expression. Recombinant SIV.F/HN vector expressing a secreted reporter protein Gaussia luciferase showed expression in the mouse lung lumen 1 month after lung administration. A single dose of rSIV.F/HN encoding novel anti-influenza bnAb (T1-3B) in a single Open Reading Frame directed expression of T1-3B into the lung lumen and systemic circulation, and conferred partial protection against lethal influenza challenge. Intramuscular (IM) delivery of a recombinant adeno-associated virus vector (rAAV2/8), previously reported to be effective against influenza challenge in mice, directed levels of T1-3B that conferred complete protection against influenza challenge. Daily repeat administrations of rSIV.F/HN did not improve protection against influenza challenge, but the ability of this vector to be repeatedly administered without loss of efficacy may be an advantage in potential clinical applications. Engineering of the bnAb, into the IgA1 backbone greatly enhanced the potency of several bnAbs and might improve influenza protection mediated by rSIV.F/HN. In conclusion, prophylaxis provided by gene transfer during an influenza pandemic might be feasible, providing long-lasting, more cost-effective and time-responsive protection than traditional vaccines or parenteral administration of therapeutic antibody.
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Davis, Harrison E. C. "An investigation of a possible non-neuronal cholinergic system in the vasculature." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:9249c66f-f074-41ce-83a4-029d654d5124.
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Vascular endothelial cells express muscarinic acetylcholine receptors, which lead to NO- and endothelium derived hyperpolarization responses that constitute major pathways for vasodilation. As evidence suggests that perivascular nerves may not represent a viable source of innervating ACh, we investigated whether suggestions of a 'non-neuronal cholinergic system' within the vasculature might act as a source of ACh that is able to influence the endothelium. Rat mesenteric arteries were cut open and held as an en-face preparation with the endothelial cell (EC) layer exposed to measure EC [Ca2+]i. Furthermore we present the first example of EC tubes isolated from rat mesenteric arteries, used to measure EC [Ca2+]i. Immunohistochemistry was performed on intact arteries to demonstrate localization of important cholinergic proteins. Direct application of rat whole blood induced increased Ca2+ activity in ECs that did not appear to rely on shear stress or other mechanical interaction of the blood with the endothelial cells. This response, shown to rely on IP3 mediated Ca2+ release, was attenuated by the muscarinic antagonist atropine; it was concluded that blood contains or induces the release of non-neuronal ACh. The localization of the ACh synthesizing protein, choline acetyltransferase by immunohistochemistry provides evidence for a source of ACh originating within the endothelium. In accordance with this, the blocker of high affinity choline uptake, hemicholinium-3, had a significant effect in reversing choline potentiated responses in ECs. Taken together, we proposed that ACh is released potentially via organic cation transporter proteins located in the endothelium, upon stimulation by blood in response to an as yet undetermined signal. The ability to influence EC Ca2+ highlights a role for blood in the local control of these cells and the data presented suggest ACh produced locally may provide physiological relevance by exerting influence on endothelial M3 muscarinic acetylcholine receptors.
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Ruckli, Beatrix. "The meaning of creative activities in the lives of people in remission from mental illness." Thesis, University of Brighton, 2016. https://research.brighton.ac.uk/en/studentTheses/fc01d70f-f071-46fa-9d19-a64c590cb6bf.
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Traditionally, creative activities have been used in occupational therapy practice as an intervention with people who have a mental illness. Recent research has explored engagement in creative activities with people living with disabilities, mental illness, retired people and people with cognitive impairment. The findings centred on positive emotions, increase in self-confidence and respite from worrying thoughts. Anecdotal evidence from local occupational therapy practitioners and arts organisations suggested that people in remission of mental illness seemed to use creative activities in their daily lives as a way to keep well, but deeper understanding was missing about this. The first aim of this study was to gain a deeper understanding of the phenomenon of voluntary participation in creative activities by people in remission of mental illness. The second aim was to explore and provide evidence of any relationship between well-being and creative activities as it was perceived by the participants. The research utilised a hermeneutic phenomenological approach. Qualitative data were collected through interviews with participants, transcribed verbatim and analysed within the hermeneutic tradition. Ten participants volunteered and were recruited by mental health NHS staff in central England. All participants had a diagnosis of a mental illness but were in remission from between six months and seven years at the time of the interviews. The data were analysed via my own interpretation of Cohen, Kahn and Steeves’ (2000) approach to hermeneutic phenomenological data analysis. The findings revealed that for all participants, engagement in their chosen creative activity evoked enjoyment and was of particular personal significance and meaning. Their subjective experiences highlighted the possible therapeutic potential of creative occupation, in particular, temporary mental relief from self-referential thoughts through deep immersion into the creative process. Deep engagement in creative occupation encompassed different types of optimal experience and might have a soothing effect on the Default Mode Network. The deliberate engagement in creative activities supports Wilcock’s theory of the use of occupation for self-restoration and keeping healthy. Additionally, the real contact with people and places facilitated a more active lifestyle which impacted also positively on the participants’ sense of well-being. The findings of the study are discussed from an occupational science perspective to extend our understanding of the solitary and group nature and effects of participation in creative activities.
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Noiret, Christophe. "Modèles éléments finis du pressage, du fluage et du soufflage du verre." Valenciennes, 1996. https://ged.uphf.fr/nuxeo/site/esupversions/c7f770ab-f0a7-47b2-8040-68a6f0458416.
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Pour prévoir et mettre au point la mise en forme d'articles volumiques en verre, les modèles éléments finis et les simulations numériques sont développées pour trois grands procédés : le pressage, le fluage et le soufflage. Par une formulation thermomécanique découplée, les modèles tiennent compte de l'écoulement newtonien du verre en présence des conditions de contact fortement évolutives au cours de la mise en forme ; la convection avec l'air et la conduction avec les outils sont estimes, soit par un modèle éléments finis en formulation implicite, soit de manière originale par un calcul analytique de la distribution de température limite à l'épaisseur de l'article en verre. Ces modèles sont utilisés avec succès pour une analyse de sensibilité des trois procédés aux paramètres géométriques et processus, en vue de leur optimisation et de leur validation, lors de la fabrication d'articles type issus des catalogues de fabricants verriers. Enfin, en s'appuyant sur le savoir-faire et les relevés expérimentaux, ces modèles numériques permettent la recherche de solutions adaptées, lors de la fabrication de deux articles de référence dans des situations extrêmes de formage.
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Gobin, Damien. "Étude de problèmes de diffusion inverse à énergie fixée pour des variétés asymptotiquement hyperboliques." Nantes, 2016. http://archive.bu.univ-nantes.fr/pollux/show.action?id=19e4187d-f072-4f00-a81c-f636386c7d24.
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On étudie des problèmes de diffusion inverse à énergie fixée pour différents types de géométries ayant plus ou moins de symétries. On commence par obtenir un résultat de diffusion inverse local à énergie fixée pour l’équation de Dirac sans masse et sans charge sur des variétés asymptotiquement hyperboliques et à symétrie sphérique. Dans un second chapitre on s’intéresse aux trous noirs de type Reissner-Nordström-de Sitter qui sont des solutions à symétrie sphérique et électriquement chargées de l’équation d’Einstein. On obtient alors un résultat de diffusion inverse à énergie fixée pour l’équation de Dirac massive et chargée. Enfin, on s’intéresse à des variétés de Stäckel de dimension trois ayant la topologie d’un cylindre torique, satisfaisant la condition de Robertson et munies d’une structure asymptotiquement hyperbolique. Sur ces variétés on utilise la théorie de séparation des variables pour l’équation de Helmholtz et une version multivariable de la méthode de Complexification du Moment Angulaire afin d’obtenir un résultat de diffusion inverse à énergie fixéeWe study inverse scattering problems at fixed energy for different geometries with more or less symmetries. First, we obtain a local inverse scattering result at fixed energy for the massless and chargeless Dirac equation on asymptotically hyperbolic manifolds with spherical symmetry. In a second chapter, we are interested in Reissner-Nordström-de Sitter black holes which are spherically symmetric and electrically charged solutions of the Einstein equation. We then obtain an inverse scattering result at fixed energy for the massive and charged Dirac equation. Finally, we are interested in Stäckel manifolds of dimension three with the topology of a toric cylinder, satisfying the Robertson condition and endowed with an asymptotically hyperbolic structure. On these manifolds we use the variable separation theory for the Helmholtz equation and a multivariable version of the method of Complexification of the Angular Momentum in order to obtain an inverse scattering result at fixed energy
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Neyrat, Mathieu. "Contribution à l’étude de G. P. R. (Ground Penetrating Radar) multicapteurs : Méthodes directes et inverses en temporel." Limoges, 2009. https://aurore.unilim.fr/theses/nxfile/default/a81b4d3c-f079-405b-88a2-1f087d9726f1/blobholder:0/2009LIMO4003.pdf.
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Les radars à sondage de sol aussi appelés GPR (Ground Penetrating Radar) jouent un rôle important pour la prospection non destructive dans des domaines très variés. Ce travail propose une étude théorique de ce type de radar dans une configuration multicapteur. Dans un première partie, les lois fondamentales de l’électromagnétisme ainsi que le principe de fonctionnement d’un radar GPR sont présentés. Une méthode numérique permettant la modélisation rapide d’une scène réaliste et le calcul de B-scan est décrite. Cette méthode basée sur la FDTD (Finite Difference Time Domain) a permis de tester différentes configurations de radars multicapteurs et d’en montrer leur apport. La dernière partie propose deux méthodes inverses dans le domaine temporel. La méthode de retournement temporel et la méthode de focalisation de phase s'avèrent bien adaptées à la localisation d’objets à partir d’enregistrements provenant de radars multicapteursGround Penetrating Radars (G. P. R. ) contribute in non-destructive survey in various domains. This work deals with a study of GPR in multisensor configuration. In a first part, the fundamental laws of electromagnetism and the radar principle are presented. A numerical method for fast modeling of realistic scenes and B-scan calculation is described. This method based on the FDTD (Finite Difference Time Domain) allowed to test various configurations of multisensor radar and to show their contribution. The final section proposes two inverse methods in time domain. The reverse time method and the phase shift method are well suited to the location of objects from multisensor radar records
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Kenny, Daryl Evan. "A force for good : exploring the future of non-crime policing." Thesis, University of Portsmouth, 2016. https://researchportal.port.ac.uk/portal/en/theses/a-force-for-good(78f7bf16-f077-4044-b3e0-2552d5bd6d6a).html.
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Crime is promoted by the government as being the primary task of the police, yet such a focus marginalizes the extraordinary prominence and relevance of many non-crime policing activities. This research highlights the breadth and complexity of those duties, filling a gap in the literature by exploring the possible future of non-crime policing. The research draws on extensive literary sources and utilizes quantitative data covering eight years of public calls made to the Staffordshire Police. The research includes qualitative data obtained from thirteen semi-structured interviews with individuals who have extensive policing experience. The research found that public demand for policing declined over the reviewed period, with staffing levels in Staffordshire dropping and government funding falling drastically. There were marked increases in ‘concern for safety’ incidents, ‘suicides’ and cases involving individuals suffering mental health crises. The research explored policing from a historical perspective drawing on European and British history, ancient and modern, in order to help shine a light on prospective future developments. The research suggested that policing is torn between those who feel that non-crime matters are important and those who think that policing should be largely crime-focused. Concerns were raised about the on going politicization of policing, the extended police hierarchy and the impact of neo-liberalism on non-crime demand. Non-crime policing appears to be moving incrementally towards pluralization and privatisation, though it could also help initiate a more unified, internationalized policing service built around human rights. All futures remain open and it is up to all of us to decide what that future will ultimately be.
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Meredew, Victoria. "Perceived control and school attendance." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/perceived-control-and-school-attendance(1d33d2ef-f07c-45d6-af17-3d30acfa7fba).html.
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This research explores the link between pupils’ perceived control and their level of attendance in school. Whilst there is research into the link between perceived control and disaffection in pupils it has not been possible to identify any research which links school non-attendance to perceived control. Research into pupils’ reasons for non-attendance identified a range of different factors, many of which the author felt could be attributed to perceived control. Forty-one participants took part in the study. Participants were male and female year nine pupils at two secondary schools in the north west of England. Participants were grouped according to their levels of attendance as high (98%+) attenders, mid-range attenders (90-94%) and low (below 80%) levels of attendance. Participants’ levels of perceived control were measured using the Multi-dimensional Measure of Children’s Perceptions of Control (MMCPC) (Connell 1985). This research also explored the pupils’ experiences of school using appreciative inquiry. Responses on the MMCPC were analysed using a one way ANOVA and descriptive statistics. No significant differences were found between scores for each of the attendance groups and the reasons for this are discussed. Thematic analysis of focus groups with an appreciative inquiry structure identified key themes raised by pupils in regard to positive experiences in school. The findings for both parts of the research are discussed and suggestions for the implications for future research and the practice of teachers and educational psychologists supporting attendance in school are made.
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Abusara, Osama. "Neuropeptide antagonists for cancer treatment." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/neuropeptide-antagonists-for-cancer-treatment(e2f22b9f-f0a7-432d-89c4-7e65a2c71b69).html.
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Small Cell Lung Cancer (SCLC) is an aggressive form of cancer accounting for 25% of lung cancer deaths worldwide. Treatment relies on combination chemotherapy (etoposide and cisplatin or carboplatin) with or without radiation therapy. However, disease relapse and resistance occurs quickly, prompting unmet need for alternative treatment options. One such option is the use of broad-spectrum antagonists, known as Substance P (SP) analogues. Historically, these analogues have not succeeded clinically due to low potency and bioavailability. In this project, novel SP analogues were developed to address these shortfalls. A chemical strategy was designed to synthesise novel short peptides including DMePhe-DTrp-Phe-DTrp-Leu-NH2 (25) as the new lead. Fmoc and Boc D-Trp derivatives with indole nitrogen having substituents (methyl, ethyl, propyl, butyl, pentyl, propargyl, benzyl and tert-prenyl) were made and characterised by 1H and 13C NMR spectroscopy and mass spectrometry (MS). These building blocks were incorporated into the first series of peptides, substituting the D-Trp residue located near the C-terminal of 25, via solid and/or liquid phase procedures. Final products were purified by RP-HPLC to >90% purity and structures verified by MS and/or 1H NMR. Cell viability assays were conducted to evaluate cytotoxicity against two SCLC cell lines: H69 (chemo-naive) and DMS79 (from a patient after treatment). The IC50 values for the D-Trp residue modified peptides were < 5 μM. One of the earliest candidates to emerge from this work was DMePhe-DTrp-Phe-DTrp(N-tert-prenyl)-Leu-NH2 (33). Subsequently, the most potent peptide was the one bearing D-Trp(N-butyl) (29) with IC50 values of 1.0 μM (H69) and 1.4 μM (DMS79), compared to the lead 25 with IC50 values of 30.7 μM (H69) and 23.0 μM (DMS79). A second series of peptides were produced to optimise 29 by incorporating a D-Trp(N-butyl) residue. The study focused on peptides by (a) modifying the N-terminal D-Trp residue, (b) modifying both D-Trp residues, (c) changing the C-terminal amide to free carboxylic acid, and (d) adding a charged amino acid (arginine) or removing a hydrophobic amino acid (leucine) to additionally aid in solubility. The most potent candidate was found to bear dual D-Trp(N-butyl) residues (35) with IC50 value of 0.6 μM (H69) and 2.3 μM (DMS79). Peptides 29 and 35 were at least 26 times more potent than SP antagonist G (SPG, previously subjected to a Phase I clinical trial), as revealed by in vitro screening in this project. Both sequences induced apoptosis as evident from fluorescence staining. Flow cytometric analysis of 29 with the DMS79 cell line showed that the level of late apoptotic cells rose from 36% at 2 μM to 96% at 6 μM, compared to 25 that exhibited no effect. Efficacy of peptide 33 was separately evaluated in vivo using DMS79 xenografts. A low dose (1.5 mg/kg) was found to reduce tumour growth by ~ 30% (p < 0.05) at day 7, relative to the control group. Higher doses could not be used due to limited aqueous solubility. Furthermore, these peptides were shown to have improved stability. Exposed to neat mouse plasma for 48 hours, 29 and 35 remained intact by 68.5% and 81.0%, respectively, compared to 59.0% for 25 and 35.9% for 33. Complete metabolic stability of 29 and 35 was observed after 3 hours incubation in mouse S9 liver fraction. Aqueous solubility issues were overcome in feasibility studies incorporating 29 into liposomes for future in vivo efficacy testing. Finally, due to the high potency and stability of 29, a liposomal formulation of it may have a profound effect in in vivo efficacy studies against chemo-resistant SCLC.
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Crow, Megan. "Investigating histone deacetylase four in sensory neurons." Thesis, King's College London (University of London), 2014. https://kclpure.kcl.ac.uk/portal/en/theses/investigating-histone-deacetylase-four-in-sensory-neurons(b1b9b716-f070-48a8-b380-f79f113d4f86).html.
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Histone deacetylase inhibitors are analgesic in preclinical pain models but the contribution of specific histone deacetylases (HDACs) to pain states remains unclear. HDAC4 is a transcriptional co-repressor that has previously been linked to aberrant nociception and synaptic plasticity. The aim of this project was to investigate the role of HDAC4 in vivo using the Cre-loxP system to conditionally delete HDAC4 from primary sensory neurons and characterize transcriptional and behavioural outcomes in models of pain and peripheral nerve regeneration. To do this I established two novel HDAC4 conditional knockout strains that enabled investigation of HDAC4 in both sensory neuron development and in adult sensory processing. In both strains, loss of HDAC4 was associated with altered expression of the gene encoding the transient receptor potential cation channel member A1 (Trpa1) and the voltage-gated calcium channel subunit α2δ-1 (Cacna2d1) in naïve ganglia. Bioinformatics analysis indicated that HDAC4 may bind Cacna2d1 directly. Furthermore, across many injury paradigms I found that HDAC4 conditional knockouts expressed lower levels of calcitonin-related polypeptide alpha (Calca) and the gene encoding the high-affinity nerve growth factor receptor (Ntrk1). While peripheral expression of HDAC4 was not required for sensory neuron differentiation, peripheral nerve regeneration or for the development of mechanical hypersensitivity in neuropathic pain models, I found highly reproducible and significant attenuation of thermal hypersensitivity in models of chronic inflammation. This was associated with significantly reduced mRNA expression of the transient receptor potential cation channel member V1 (Trpv1) and reduced capsaicin sensitivity in vitro, possibly as a result of aberrant nerve growth factor signaling. HDAC inhibitors and other drugs that target chromatin modifying and transcriptional regulatory proteins are already being used clinically to treat cancer. Work to characterize the function of these molecules in diverse systems will provide a rational basis for the broader application of these therapies.
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Medina, Medina Humberto Jesus. "Study of steady and pulsating impinging jets." Thesis, Queen's University Belfast, 2008. https://pure.qub.ac.uk/portal/en/theses/study-of-steady-and-pulsating-impinging-jets(8101f081-f0ca-4ef6-a895-369b489a1d17).html.
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An experimental investigation on the fluid mechanics of steady and pulsed impinging jets is presented in this thesis. An experimental facility was custom-builtin order to generate axisymmetric and incompressible impinging jets (pulsed and steady). In order to ensure that the velocity profiles at the exit were fully developed, the jet was discharged from a round nozzle of 50 diameters in length. The effects of the Reynolds number, the nozzle-to-plate spacing and the Strouhal number were investigated systematically. The range of the Reynolds numbers covered is 4000 to 10000 for the steady jets, and 4200 to 10240 for the pulsed jets. The nozzle-to-plate spacings considered are 2, 3 and 4 nozzle diameters,because at these distances heat transfer enhancement is present for pulsed jets. The Strouhal number ranges from 0 (steady case) to 0.5. It was found that the Reynolds number does not affect the flow field of impinging jets as significantly as the nozzle-to-plate spacing, in particular, for pulsed jets, which exhibit significant changes in the distribution of the Reynolds stresses near the impinging wall for small nozzle-to-plate spacings. In addition, it was also found that the axial convection term of the mean axial momentum balance near the impinging wall is significantly larger for a jet pulsed at St _ 0:5 than its steady counterpart when H=d = 4. This work also expands the present knowledge base of both steady and pulsed jets in three main areas; (1) it presents in-depth velocity measurements and turbulence statistics for pulsed and steady jets, (2) the transitional regime of impinging jets is examined, and finally, (3) it presents data for turbulence model validation of a real incompressible pulsed jet.
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Thompson, Henry. "Freedom from choice : the persistence of censorship in post-1968 American cinema." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/freedom-from-choice-the-persistence-of-censorship-in-post1968-american-cinema(970b7db4-f08a-4f64-b195-bac6b23fcde0).html.
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Jack Valenti, then President of the Motion Picture Association of America (MPAA), formally announced the commencement of a new Motion Picture Code and Rating Program on November 1, 1968; a mode of industry self-regulation designed to replace the, by then discredited, Production Code. Despite the Program's intended role in providing freedom of choice, censorship has persisted after 1968. Censorship is defined here as the efforts by some to restrict the viewing options of others, for reasons of personal morality, commercial self-interest or ideological necessity. American moviegoers and other consumers of American cinematic culture have, paradoxically, been freed from choice. The availability of 24/7 porn on cable television and the undoubted explosion of explicit violence in mainstream cinema after 1968 are superficial distractions from the homogenising effects of both the pressure to make movies that can be screened to large predominantly teenage audiences and the pressures not to upset vocal pressure groups. In extending and mapping out the territory of the consumer the industry has, both in the types of movie on offer and in the mode of regulation chosen, effectively curtailed the space for the citizen to ask more demanding questions either about movie content or about the benefits of allowing a small number of media conglomerates to construct the viewing menu. The Program remains in place but its efficacy has been widely questioned. The thesis breaks the development of the Program into three phases organised around Richard Heffner's operation of the Program between 1974 and 1994. In the early years, despite the self-styled liberalism of the New Hollywood renaissance, both ideological and commercial constraints were applied to content. Only after Heffner's arrival in 1974 did the Program begin to function as Valenti had originally envisaged. However, the slow emergence of narrowcasting and the expansion of conglomerate ownership ensured the continuance of commercial self-censorship. These changes found maturation in a third phase of the Program's operation, after 1994. The research considers evidence of commercially motivated self-censorship as well as evidence of politically motivated censorship. The cumulative effect of industry change has been a commodification of entertainment- a denial of any interest other than that of the consumer- and the privatisation of a key part of the process of setting cultural norms. The thesis considers the risks for a functioning democracy posed by the emergence of a global entertainment complex that has an overwhelming economic interest in shaping the 'marketplace of ideas'.
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Makoelle, Tsediso Michael. "Exploring teaching practices that are effective in promoting inclusion in South African secondary schools." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/exploring-teaching-practices-that-are-effectivein-promoting-inclusion-in-south-africansecondary-schools(7b2127b0-f07f-4c9a-9708-95c37b078bdf).html.
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Prior to the advent of the new democratic political dispensation in 1994, South African education had laboured under racially motivated discriminatory practices of active exclusion of the majority of learners. The authoritarian system located educational problems in the perceived deficiencies of the learner rather than in the repressive, top-down, non-participative, unreflective and uninclusive practices of the prevailing educational orthodoxy of the time. After 1994, the broader reconceptualisation of South African education sought to redress the imbalances of the past by creating equal opportunities for all learners, irrespective of race or creed. However, the difficult conundrum was how such a complex systemic change could be driven by teachers who had not only been trained in a heavily segregated educational system but formed part of it. Therefore, the aim of the thesis was to determine how teachers conceptualised inclusive teaching, explore the teaching practices that were believed to be effective in promoting inclusion in the South African secondary classrooms, and determine how they could be developed. The two-dimensional research study firstly took the form of a qualitative collaborative action research project conducted with a team of fifteen teachers at a single South African secondary school. The project was non-positivistic, critical, emancipatory and allowed the participants jointly to define the constructs of inclusive education, inclusive teaching and inclusive class; to identify practices of inclusion through observation; to adopt other practices in their classes; to determine the effect of such practices on inclusive teaching and learning; and finally to draw conclusions about the specific practices that were clearly effective in the context of their school. Secondly, an inductive analytical framework was used by the researcher to determine the theoretical contribution the study would make to the notion of developing inclusive teaching practices and determining the way this could be achieved within the South African school context. Data were collected through a series of meetings, participant observations, focus-group interviews, and one-on-one semi-structured interviews during the action-research stages of planning, action and reflection. Limitations were the teacher-researchers' lack of experience in conducting research and the limited time the research team had to complete the research tasks. The findings indicate that, at the time of the research, the conceptualisations of inclusive teaching and inclusive pedagogy were varied and continued to be influenced by the former special-needs education system. Moreover, the findings show that, while the inclusive practices identified by the teachers in this study are popular in the international literature, they need to be contextualised in and made relevant to the South African situation. However, it is clear that the teachers' experience of participating in the action-research process had raised their awareness of the importance of inclusive teaching, promoted a sense of emancipation, and held out the prospect of successful and possibly lasting change. These findings clearly imply that the reconceptualisation of inclusive pedagogy should always take place within a specific context, and that South African teachers in particular should form communities of inquiry to reflect on and develop their inclusive practices. The study has captured the essence of inclusion within the South African school context and has identified areas that need further research, for example the impact of different cultural beliefs on both teachers and learners in relation to inclusion. In conclusion, the study has demonstrated the unique contribution of action research in promoting continuous reflection, revision and intervention as indispensable procedures in the process of improving inclusive teaching and learning.
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Shuttleworth, Emma Louise. "Tracing peatland geomorphology : sediment and contaminant movements in eroding and restored systems." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/tracing-peatland-geomorphology-sediment-and-contaminant-movements-in-eroding-and-restored-systems(6af5d1e1-f01a-4a1d-8ddd-f5027574c087).html.
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Peatlands are an important store of soil carbon, play a vital role in global carbon cycling, and can also act as sinks of atmospherically deposited heavy metals. Large areas of the UK’s blanket peat are significantly degraded and actively eroding, which negatively impacts carbon and pollutant storage. The restoration of eroding UK peatlands is a major conservation concern, and over the last decade measures have been taken to control erosion and restore large areas of degraded peat. In severely eroded peatlands, topography is highly variable, and an appreciation of geomorphological form and process is key in understanding the controls on peatland function, and in mitigating the negative impacts of peatland erosion. The blanket peats of the Peak District, Southern Pennines, UK, embody many problems and pressures faced by peatlands globally, and are amongst the most heavily eroded and contaminated in the world. The near-surface layer of the peat is contaminated by high concentrations of anthropogenically derived, atmospherically deposited heavy metals, which are released into the fluvial system as a consequence of widespread erosion. Whilst not desirable, this legacy of lead pollution and its release, offer a unique opportunity to trace peatland sediment movements and thus investigate the controls on sediment and contaminant mobility. A suite of established field, analytical and modelling techniques have been modified and adapted for use in peatland environments: (i) by incorporating a simple correction for moisture content, field portable XRF has been shown to be an accurate, cost-effective, and rapid tool for assessing in situ lead concentrations in wet organic sediments; (ii) a lightweight time integrated mass flux sampler has been developed for deployment at multiple remote peatland field sites, and has been used to explore spatial and temporal suspended sediment dynamics; and (iii) sediment source fingerprinting and numerical mixing models, traditionally used to determine sources of fine sediment in minerogenic systems, have been used to investigate suspended sediment composition in contaminated organic rich catchments. These modified methods have been successfully employed in combination to address issues of sediment and contaminant release. Several mechanisms and controls have been shown to be important influences on sediment dynamics and Pb release across a range of spatial and temporal scales: (i) the presence of vegetation is key in stabilising the peat’s surface and trapping mobilised sediment; (ii) sediment preparation influences the timing of POC and Pb release; (iii) antecedent water tables may control the timing and the nature of sediment entering the fluvial system during storm events; and (iv) the degree of degradation influences both Pb storage and release. At the landscape scale, peatland restoration significantly mitigates sediment production in eroding peatlands and substantially reduces carbon and pollutant export. At the catchment scale, sediment preparation and hydrological connectivity are important controls on the magnitude and timing of sediment and lead fluxes from eroding peatland catchments. At the plot scale, complex small scale spatial patterns of contaminant storage in eroding headwater catchments can be explained by interactions between topographic setting and vegetation cover, and the mobilisation of sediment by wind and water. This deeper understanding of the multi-scalar dynamics of sediment movements in eroding peatlands is important in the context of: (i) the release and reworking of legacy contamination in organic rich systems; (ii) the response of blanket peats to climate change; (iii) informing future restoration strategies that aim to manage peatland sediment and contaminant fluxes.
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Monger, David. "The National War Aims Committee and British patriotism during the First World War." Thesis, King's College London (University of London), 2009. https://kclpure.kcl.ac.uk/portal/en/theses/the-national-war-aims-committee-and-british-patriotism-during-the-first-world-war(95dde034-f075-4b5f-a0d4-4d9179a8e6d5).html.
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This thesis discusses the National War Aims Committee (NWAC), a cross-party, Treasury-funded Parliamentary organisation established in mid-1917 to conduct domestic propaganda. The thesis provides the most comprehensive examination of its organisational structure, expanding upon and correcting existing historical treatments, and demonstrating that it was a more significant element of British wartime society than previously assumed. It also provides much greater discussion of the NWAC's reception by Parliament, the press and the public. The thesis provides extensive analysis of the representation of patriotism in NWAC propaganda. This exceeds existing work, considering all its printed propaganda, but also reports of NWAC events in over a hundred newspapers in thirty localities. This detailed analysis suggests that NWAC propagandists retained many familiar themes of pre-war patriotism and national identity. This observation counters assumptions that pre-war patriotism was nullified by the mass casualties suffered by patriotic volunteers. However, I argue that while basic patriotic themes remained recognisable, NWAC propaganda reconfigured them in a narrative reflective of the experience of war-weary civilians. The propaganda generally revolved around a core idea of duty, supplemented by one or more contextual elements which demonstrated its necessity. I suggest several categories of interactive and interdependent `presentational patriotisms' used by propagandists to influence civilian attitudes. Further, I demonstrate that each category is discernible more widely in pre-war settings, suggesting that, while the model narrative might vary in different situations, the general history of British patriotism might benefit from applying the evidence of my thesis to other examples. I challenge the significance of the familiar `otherness' paradigm of national identity, suggesting that the recognition of difference was only part of the patriotic narrative supplied by the NWAC. Further, my analysis is particularly concerned with the interactions between local, national and supranational sources of identity, often overlooked or under-examined by historians
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Morales, Demarco Manuela. "Mineralogical, Petrophysical and Economical Characterization of the Dimensional Stones of Uruguay; Implications for Deposit Exploration." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F07A-C.
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Goudon, Valérie. "Magnétisme nucléaire de l'3He liquide : nouvelle détermination du paramètre de Landau F0a." Phd thesis, 2006. http://tel.archives-ouvertes.fr/tel-00177281.
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L'3He est un liquide de Fermi modèle, isotrope, pur, de température de Fermi accessible, et dont les interactions sont aisément contrôlées en faisant varier la pression du liquide. Ce manuscrit présente des mesures précises de susceptibilité magnétique nucléaire par RMN continue de l'3He liquide en fonction de la température et de la pression. Les principaux efforts expérimentaux sont portés sur la thermométrie, la mesure de la pression de l'3He in situ pour étendre les mesures jusqu'à la pression de solidification, ainsi qu'une caractérisation soigneuse du spectromètre RMN. Nos mesures remettent en cause d'environ 5% les résultats de référence pour la température de Fermi effective en fonction des interactions. L'extraction du paramètre de Landau F0a dépend aussi de la masse effective déterminée par des mesures de chaleur spécifique, et par conséquent de l'échelle de température. La ré-analyse des mesures de chaleur spécifique dans l'échelle PLTS-2000 implique une augmentation de la masse effective de 4,5%. F0a est donc déterminé dans ce manuscrit pour deux échelles de température (PLTS-2000 et Greywall). Contrairement aux résultats antérieurs, la dépendance en densité de F0a ne montre pas de saturation vers les hautes pressions.
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Hammersen, Annette. "Die Pathogenese der chronischen Herzinsuffizienz bei Säuglingen mit angeborenem Herzfehler und Links-Rechts-Shunt am Beispiel der klinischen Symptome Tachypnoe und Gedeihstörung." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F03A-9.
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Springer, Björn. "Polybutadien und Butadien enthaltende Copolymere mit kontrollierter Kettenstruktur mittels RAFT-Polymerisation." Doctoral thesis, 2011. http://hdl.handle.net/11858/00-1735-0000-000D-F04A-5.
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Baum, Sarah. "Phytodiversity in Short Rotation Coppice plantations." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F05A-1.
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Müller, Robert. "Policy options to reduce deforestation in the Bolivian lowlands based on spatial modeling of land use change." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F07E-4.
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Koch, Sebastian. "Natural Resource Use Conflicts in Indonesia: A Challenge for Sustainable Development and Education for Sustainable Development." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F079-E.
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Tum, Markus. "Modelling and validation of agricultural and forest biomass potentials for Germany and Austria." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F07B-A.
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Doummar, Joanna Jean. "Identification of indicator parameters for the quantitative assessment of vulnerability in karst aquifers." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F07C-8.
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Köhler, Stefan. "Bestandes- und Freilandnährstoffeinträge in Zentralsulawesi (Indonesien)." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F07D-6.
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Grenz, Michael. "Entwurf und Beschreibung wesentlicher Komponenten einer Sicherheitsarchitektur für medizinische Forschungsnetze." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F06A-E.
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Hameed, Sufian. "Leveraging Email based Social Networks to Prevent Spam: Framework, System Design and Evaluation." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F070-F.
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Ober, Ulrike. "Genomic Prediction for Quantitative Traits: Using Kernel Methods and Whole Genome Sequence Based Approaches." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F071-D.
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Aksoy, Eren Erdal. "Semantic analysis of image sequences using computer vision methods." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F072-B.
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Abramov, Alexey. "Compression of visual data into symbol-like descriptors in terms of a cognitive real-time vision system." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F073-9.
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Palm, Marc. "Explicit GL(2) trac formulas and uniform, mixed Weyl laws." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F074-7.
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Sohns, Melanie. "The Empirical Hierarchical Bayes Approach for Pathway Integration and Gene-Environment Interactions in Genome-Wide Association Studies." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F075-5.
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Taheri, Somayeh. "Anonymity and Privacy in Wireless Mobile Ad Hoc Networks." Doctoral thesis, 2011. http://hdl.handle.net/11858/00-1735-0000-000D-F076-3.
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Dong, Zhijie. "Prediction of Protein-Protein Interaction Sites with Conditional Random Fields." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F077-1.
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Memarmoshrefi, Parisa. "A Bio-Inspired Autonomous Authentication Mechanism in Mobile Ad Hoc Networks." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F078-0.
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Christoph, Johannes. "Die Herzfunktion während milder Hypothermie bei anästhesierten Schweinen: gesteigerte Inotropie auf Kosten einer diastolischen Dysfunktion." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F07F-2.
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Liese, Tobias. "Multilagenbasierte Transmissionsoptiken für die Röntgenmikroskopie." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F08A-8.
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Yuan, Li. "Die abstrakte Gestaltung von Sicherheiten als elementarer Ausdruck der Privatautonomie." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F09A-4.
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Lee, Nam-Eun. "Europäisierung deutscher Migrationspolitik." Doctoral thesis, 2011. http://hdl.handle.net/11858/00-1735-0000-000D-F0A7-6.
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Hernández, Anja. "Zur sozialen und kulturellen Bedeutung stimmungsverändernder Medikamente. Erfahrungen von deutschen Hausarztpatienten, spanischen Migranten in Deutschland und im Herkunftsland lebenden Spaniern." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F0AA-F.
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Mortensen, Lena Sünke. "Modulation of synaptic transmission by the voltage-gated potassium channel Eag1." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F0BA-B.
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Vadhvani, Mayur. "The role of E3 ubiquitin ligase FBXO31-SCF in neuronal morphogenesis." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F0CA-7.
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Deuschl, Florian G. "Molekulare Charakterisierung des murinen 66.3-kDa-Proteins." Doctoral thesis, 2008. http://hdl.handle.net/11858/00-1735-0000-000D-F0DA-3.
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Suska, Anna. "Cocaine-inducible circuitry reorganization as a basis for addiction-related memory traces." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F0EA-0.
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Fischer, Sven. "Einfluss eines Beatmungshelmes auf die Leistung zweier verschiedener Intensivbeatmungsgeräte im Vergleich zu einer Gesichtsmaske und zur invasiven Beatmung - Eine experimentelle Lungenmodelluntersuchung." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F00A-6.
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