Dissertations / Theses on the topic 'Eye'
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Dahlberg, Joakim. "Eye Tracking with Eye Glasses." Thesis, Umeå University, Department of Physics, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-32868.
Full textThis study is concerned with the negative effects of wearing corrective lenses while using eye trackers, and the correction of those negative effects. The eye tracker technology studied is the video based real-time Pupil Center and Corneal Reflection method. With a user study, the wearing of eyeglasses is shown to cause 20 % greater errors in the accuracy of an eye tracker than when not wearing glasses. The error is shown to depend on where on the eye tracker viewing area the user is looking.
A model for ray refraction when wearing glasses was developed. Measurements on distortions on the image of the eye caused by eyeglass lenses were carried out. The distortions were analyzed with eye tracking software to determine their impact on the image-to-world coordinates mapping. A typical dependence of 1 mm relative distance change on cornea to 9 degrees of visual field was found.
The developed mathematical/physiological model for eyeglasses focuses on artifacts not possible to accommodate for with existing calibration methods, primarily varying combinations of viewing angles and head rotations. The main unknown in the presented model is the effective strength of the glasses. Automatic identification is discussed. The model presented here is general in nature and needs to be developed further in order to be a part of a specific application.
Lundhe, Adrian. "Diabetic Eye Screening : Eye mapping examination application." Thesis, KTH, Skolan för informations- och kommunikationsteknik (ICT), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-211720.
Full textEnligt Världshälsoorganisationen fanns det under 1980-talet 108 miljoner diabetespatienter runt om i världen och 2014 höjdes antalet till 422 miljoner. Detta är en procentuell ökning från 4,7 till 8,5 under samma tidsperiod. Enligt rapporten Vision 2020 bidrar cirka 5% av blindheten i världen till diabetisk retinopati. 4% av dessa människor kommer aldrig att bli behandlade för deras sjukdom. Olika människor får olika behandlingar beroende på var de är i världen. De olika kostnaderna beror främst på tillgänglig utrustning, löner och länders valutor på världsmarknaden. Av 37 miljoner fall av blindhet är ca 1,8 miljoner relaterade till diabetisk retinopati. Efter 15 år med denna sjukdom kommer 2% att vara blinda och 10% kommer att ha en allvarlig visuell förlust. Vid 20 års av diabetes kommer 75% att få någon form av diabetisk retinopati. Regeringar, försäkringsbolag och sjukhus runt om i världen har problem med att hålla nere kostnaderna och bidra med tillgänglighet av medicinsk personal för behandling av patienter. Det finns ett behov av ett nytt sätt att tänka. Ett alternativ. En billig, tillförlitlig och snabb metod att upptäcka sjukdomar i tidigt skede kommer dramatiskt sänka kostnader och minska på trycket i vården behövs. Mobilapplikations marknaden är något av en outnyttjad marknad när det gäller medicinsk utrustning. För att avhjälpa frånvaron av denna typ av applikation skapades Diabetic Eye Screeningprogrammet. Applikationen kartlägger avvikelser i näthinnan och ger statistiska data för patienterna i sina egna mobiltelefoner och tablets utan att behöva möta medicinsk personal. Informationen kan på ett säkert och tillförlitligt sätt snabbt delas mellan partner för utvärdering av patientens omedelbara hälsotillstånd.
Hossain, Akdas, and Emma Miléus. "Eye Movement Event Detection for Wearable Eye Trackers." Thesis, Linköpings universitet, Matematik och tillämpad matematik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-129616.
Full textYakimov, Christopher Doyle. "Eye mySelf." Thesis, University of British Columbia, 2006. http://hdl.handle.net/2429/31740.
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Graduate
Townsend, Julie. "Peculiar Eye." ScholarWorks@UNO, 2008. http://scholarworks.uno.edu/td/697.
Full textWoudenberg, Tara Marisa. "Eye insight." Master's thesis, Faculdade de Ciências e Tecnologia, 2011. http://hdl.handle.net/10362/8383.
Full textThe purpose of this research is to gain more understanding of the scientific language. Black symbols and representations of the natural world are used to communicate complex thoughts in various dimensions. Through the process of purification I communicated with confusion and the privilege of being ignorant became my inspiration. My new self is like the alchemists; investigating in new dimensions where symbols and imagery exist to comprehend the always-surrounding unknown. With soda-lime and flat glass I created solid glass symbols. Through the microscope I looked at organic specimens and self-made glass samples and recorded what I saw. Every detail is an indispensable part of an important whole and perceiving is the key to entering new universes. My encounter with science has given me the tools to develop a greater awareness to investigate why and how I am making art. I am convinced that artists and scientists are similar in seeing the universe in unique and specific ways. It is only the representations of those visions that are phrased in different languages.
Sarraipa, Rita Poças. "Green eye." Master's thesis, Universidade de Lisboa, Faculdade de Arquitetura, 2019. http://hdl.handle.net/10400.5/18408.
Full textAtualmente, metade da população mundial (55%) habita em centros urbanos, em 2050 estima-se que aumente para dois terços (68%). Estes espaços ocupam apenas 3% da superfície do planeta, mas consomem 75% dos recursos naturais. Em 2016 entrou em vigor a resolução da Organização das Nações Unidas (onu) intitulada “Transforming our world: the 2030 Agenda for Sustainable Development”, como base para um plano de ação para as pessoas e o planeta prosperarem. A mais recente Conferência das Nações Unidas sobre Mudanças Climáticas (cop 21) explorou soluções para enfrentar as consequências do aquecimento global e traçou objetivos globais de redução de gases de efeito estufa. O turismo, uma atividade em crescimento, é parte deste problema global. Gera riqueza e poluição tendo impacto em fenómenos que ameaçam o futuro do planeta: as alterações climáticas, o consumo excessivo, o desperdício de plástico, a perda de biodiversidade, a sobrecarga das cidades, o uso de combustíveis fósseis, o consumo energético. Daí a importância cada vez maior de um turismo sustentável. O presente projeto de investigação pretende, através do design, contribuir para a criação e promoção de um novo negócio, nesta área com forte potencial de crescimento – o turismo. Materializa-se através da participação numa ideia de negócio, apoiando o seu desenvolvimento desde o início, assumindo a dimensão estratégica que o design pode ter, não só na construção da comunicação mas também no desenvolvimento e concretização da própria ideia e do seu financiamento. Esta investigação surgiu da identificação de uma oportunidade de negócio, numa área que tem apresentado um interesse crescente por parte do público. Estudou-se o mercado e o contexto onde este negócio se pode desenvolver e ainda o interesse das visitas aos espaços verdes pois eles corporizam a estratégia ambiental das cidades modernas e contam grande parte da sua história. Sem árvores as cidades seriam muito diferentes. Partindo de uma metodologia de base qualitativa, efetuou-se uma investigação de carácter teórico, através da revisão da literatura dos campos investigativos: Turismo e Design de Comunicação. Assim, desenvolveu-se um enquadramento teórico capaz de impulsionar e direcionar a componente projetual. Numa segunda fase, procedeu-se à análise de casos de estudo, compreendendo o modo como negócios internacionais, que exploram o mesmo nicho, se apresentam e divulgam a sua oferta. De seguida, foram analisados fatores relacionados com a implementação do projeto: análise swot, caracterização do público-alvo, identificação de potenciais concorrentes. Esta investigação, resulta na materialização de um projeto singular que pretende atuar num nicho de mercado, explorando e valorizando jardins e espaços verdes urbanos. Propondo dar a conhecer a história e a vida das cidades, através dos seus jardins, quer tenham centenas de anos ou menos de uma década. Despertando o interesse para o ‘verde’ – Green Eye.
ABSTRACT: Today, half of the world’s population (55%) live in urban centers, it is estimated to increase to two-thirds (68%) by 2050. Although they consume 75% of natural resources, these areas occupy only 3% of the earth’s surface. In 2016, United Nations Organization’s resolution called “Transforming our world: the 2030 Agenda for Sustainable Development” came into force as a foundation for a plan of action so that the planet and man could prosper. United Nations’ most recent conference about climate changes (cop 21) explored solutions to deal with global warming consequences and set worldwide goals in order to reduce greenhouse gases. Tourism is part of this problem . A growing activity which generates wealth and pollution. Tourism has positive aspects, however, it also has an impact on phenomena that threaten the future of the planet: climate change, excessive consumption, plastic waste, loss of biodiversity, the overburden of cities, use of fossil fuels, energy consumption, discharges. That is why having sustainable tourism is increasingly important. Resorting to design, this research project intends to contribute to the creation and promotion of a new business, in an area with strong growth potential – tourism . It is materialized through participation in a business idea, supporting its development from the beginning. Assuming the strategic dimension that design can have, not only in the construction of communication but also in the development and implementation of the idea itself and its financing. This research emerged from the identification of a business opportunity, in an area that has shown a growing interest by the public. The market and the context, where this business can be developed, were studied. The interest of the visits to the green spaces was also studied because they embody the environmental strategy of modern cities and they tell much of their history (and of their own stories). From a qualitative methodology, a theoretical investigation was carried out, through the literature review of the research fields: Tourism and Communication Design. Thus, a theoretical framework capable of boosting and directing the project component has been developed. In a second phase, case studies were analyzed, including the way in which international businesses, which explore the same niche, present themselves and disseminate their offer. Next, we analyzed factors related to project implementation: swot analysis, characterization of target audience and identification of potential competitors. As a result of this research, we have accomplish a singular project that intends to operate in a market niche, exploring and valuing gardens and green spaces in the city. Proposing to introduce the history and life of cities, through their gardens, whether they have hundreds of years or less than a decade. Awakening interest for the ‘green’ — Green Eye.
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Harbuzova, Yelizaveta Antonivna, Єлізавета Антонівна Гарбузова, and Елизавета Антоновна Гарбузова. "Bionic eye." Thesis, Сумський державний університет, 2014. http://essuir.sumdu.edu.ua/handle/123456789/38822.
Full textRoss, Catriona. "Little eye." Master's thesis, University of Cape Town, 2006. http://hdl.handle.net/11427/8091.
Full textEsquivel, Sandro [Verfasser]. "Eye-to-Eye Calibration - Extrinsic Calibration of Multi-Camera Systems Using Hand-Eye Calibration Methods / Sandro Esquivel." Kiel : Universitätsbibliothek Kiel, 2015. http://d-nb.info/1073150615/34.
Full textLind-Hård, Viktor. "What meets the eye : Naturalistic observations of air traffic controllers eye-movements during arrivals using eye-tracking." Thesis, Linköpings universitet, Institutionen för datavetenskap, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-159934.
Full textWong, Chak-ming Albert. "Feasibility study of comprehensive eye screening on low-risk persons for ocular abnormalities contribution of socio-economic and demographic variables /." Click to view the E-thesis via HKUTO, 2003. http://sunzi.lib.hku.hk/hkuto/record/B31971271.
Full textTANNFELT, WU JENNIFER. "Robot mimicking human eye movements to test eye tracking devices." Thesis, KTH, Mekatronik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-245066.
Full textEyetracking utrustning testas av människor som tittar på väldefinierade stimuli. Att testa eyetracking på det här sättet är inte tillräckligt noggrant på grund av mänskligt fel. Malet med detta examensarbete är att designa och bygga en pålitlig ögonrobot som kan härma beteendet hos mänskliga ögon. Efter en förstudie om mänskliga ögon, eyetracking och existerade robotögon formulerades system-krav och -specikationer. Baserat på dessa krav togs en del betydande designbeslut som att använda RC servomotorer, tryckstånger, mikrokontrollers och en Raspberry Pi. Senare modellerades den inverterade kinematiken av rörelserna och saccaders banor. Ytterligare mekaniska funktioner är rotation av huvudet och justering av avståndet mellan pupillerna. Roboten styrs med hjälp av två applikationsprogrammeringsgränssnitt (API). Det första API:et används för att styra motorerna och det andra API:et bygger på det första men används för att bygga rörelsevanor av olika ögonrörelser mellan fixationspunkter. Alla ögonrörelseberåkningar görs på Raspberry Pin innan rörelsen kommuniceras i realtid till mikrokontrollen som på direkten exekverar styrsignalen. Roboten testades med integrerade lasrar i ögonen och en kamera med slow motion funktionalitet för att fånga laser prickens projektion på en vägg. Funktioner som testades är saccader, smooth pursuit, huvudrotation och eyetracking kompatibilitet. Resultat visade en hög precision men inte tillräckligt hög noggrannhet. Roboten behöver några få mekaniska förbättringar som att få bort glappet i de roterande lederna på ögat, minska flexibiliteten i några av de 3D-utskrivna delarna och garantera symmetri i designen. Roboten är en kraftfull testplatform kapabel till att utföra alla typer av ögonrörelser med högupplöst kontroll av båda ögonen var för sig genom ett API.
Francis, Ian C. School of Medicine UNSW. "The watery eye." Awarded by:University of New South Wales. School of Medicine, 2007. http://handle.unsw.edu.au/1959.4/35259.
Full textKhan-Lim, Doreen. "Dry eye mucins." Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424547.
Full textBrunstein, Ada. "Eye to I." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/42147.
Full text"September 2007."
Includes bibliographical references (leaves 50-51).
This is the story of the language of eyes - what they say about our emotions, what they reveal about our intentions, how they interact with our face, and how they connect us to one another. The story follows our experience with eyes from infancy when we first learn to connect looking with knowing. This connection forms the foundation of our social understanding and has evolutionary implications. From there the story moves to gaze in love, and other social encounters. I look at the role of eye gaze in the judgments we make about others - the way in which direct eye contact may affect how likable or attractive we find another person. I then turn to these questions: how much of an eye does it take for us to feel watched? Do pictures of eyes affect us? What about the eyes of a robot - do we respond to them as we do to human eyes? I show that for those who have normally functioning eyes, attention to the eye region plays a critical role in how we learn about the social world and our place in it.
by Ada Brunstein.
S.M.in Science Writing
Babenko, A., and A. Kotenko. "The Eye Tribe." Thesis, Sumy State University, 2016. http://essuir.sumdu.edu.ua/handle/123456789/44892.
Full textTalevski, Lubo. "The mind's eye /." Online version of thesis, 1993. http://hdl.handle.net/1850/11774.
Full textHnatow, Justin Michael. "A theoretical eye model for uncalibrated real-time eye gaze estimation /." Online version of thesis, 2006. http://hdl.handle.net/1850/2606.
Full textKavasakali, Maria. "Saccadic eye movement measurements in the normal eye : investigating the clinical value of a non-invasive eye movement monitoring apparatus." Thesis, University of Bradford, 2005. http://hdl.handle.net/10454/3577.
Full textDiamantopoulos, Georgios. "Novel eye feature extraction and tracking for non-visual eye-movement applications." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/934/.
Full textNapier, Katherine Mary. "Eye to eye : the persuasive potential of direct address in the theatre." Thesis, Royal Holloway, University of London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502478.
Full textLennartsson, Emilia. "Eye-tracking och matematik : En eye-tracking-undersökning om användandet av prioriteringsreglerna." Thesis, Högskolan för lärande och kommunikation, Jönköping University, Matematikdidaktisk forskning, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-49555.
Full textThe aim of this study is to investigate what information can be gathered by studying a person’s eye movements with a simpler kind of eye-tracker device. Eye-tracking is a technique that allows studying eye movements. In this study a stationary eye-tracking device was used to study and measure eye movements. This study is an original eyetracking study, consisting of two participants who solved mathematical problems that require the use of order of operations whilst wearing an eye-tracker device. The device was a relatively cheap (cost around 1000 SEK) commercial eye-tracker with a home-made data acquisition software system. The result of the study is that it is indeed possible to collect and interpret information using an eye-tracker. Based on the results the conclusion can be made that the participants used the order of operations to solve the assignments.
Naase, Taher. "Clinical assessment of eye characteristics, sensitivity, and eye blink activity in humans." Thesis, Glasgow Caledonian University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486492.
Full textClark, Charles V. "Studies on the eye." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/23795.
Full textWIDÉN, TOBIAS. "Eye Tracking Simulation Framework." Thesis, KTH, Skolan för datavetenskap och kommunikation (CSC), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-142482.
Full textFör att underlätta utveckling av eye tracking-algoritmer har vi skapat ett simuleringsverktyg och programmeringsgränssnitt med återanvändbara komponenter. Verktyget består i huvudsak av en kärna, vilken utifrån geometriska modeller för ögon och ljuskällor, mekanismer för optisk projektion och algoritmer genererar eye tracking-data från virtuella scener samt kalibrering av ögonmodeller med algoritmer som tolkar genererat data. Vi beskriver ett urval av formella metoder och principer för mjukvaruutveckling och exemplifierar hur dessa kan användas för att förbättra funktionalitet och användbarhet av mjukvara. Slutligen diskuterar vi framtida användningsområden och förbättringar som ytterligare kan öka verktygets användbarhet och ingenjörsmässighet.
Santoro, Loredana. "Perception during eye movements." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418156.
Full textLaidlaw, David Alistair Hunter. "Second eye cataract surgery." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322548.
Full textVollmar, Anne Marie. "Screening of Eye Coordination." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1212005075.
Full textOrchard, Rebecca L. Orchard. "Eye of the Firmament." Bowling Green State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1530282981789348.
Full textMontecalvo, Natalie R. "Study of Eye Convergence." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1565966301837973.
Full textFick, Cornelia. "Eye of a needle." Thesis, Rhodes University, 2016. http://hdl.handle.net/10962/d1021210.
Full textMarshall, Christine. "Elizabeth Bishop's revisionary eye /." free to MU campus, to others for purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p1420938.
Full textBednar, James Albert. "Learning to see genetic and environmental influences on visual development /." Access restricted to users with UT Austin EID Full text (PDF) from UMI/Dissertation Abstracts International, 2002. http://wwwlib.umi.com/cr/utexas/fullcit?p3077406.
Full textSuda, Kenji. "High‐density lipoprotein mutant eye drops for the treatment of posterior eye diseases." Kyoto University, 2018. http://hdl.handle.net/2433/231013.
Full textFarmer, John William. "Developing eye care and an analysis of eye conditions in Papua New Guinea." Connect to thesis, 2007. http://repository.unimelb.edu.au/10187/1730.
Full textGu, Jianjun Jason. "Design, sensing and control of a robotic prosthetic eye for natural eye movement." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ60293.pdf.
Full textAnderson, Lauren. "Seeing Eye to Eye| A sexuate aesthetic development model for art and education." Thesis, California State University, Long Beach, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=1526890.
Full textSeeing Eye to Eye is a case study connecting relationships between aesthetics, aesthetic development, and gender. This study identifies major trends of aesthetic experience unique to sexual difference and gender. Viewers develop frameworks for making meaning from artworks that consist of epistemologies accumulated through education, socialization and individual experience. The dominant pedagogy is a logical tradition that teaches universal meaning. Emergent themes in student responses showed that ways of viewing and speaking about artworks are usually extrinsic or intrinsic. Extrinsic approaches privilege individual artistic agency, action, contrast and shadows, message delivery, and technical fabrication of an image. Intrinsic frameworks for viewing favor creative narration and characterization, details and textures, and personal emotional metaphor. The model created from the research equalizes a variety of aesthetic strengths, while recognizing when an individual is in possession of many strengths in looking at and talking about works of art. I created a model that catalogues extrinsic and intrinsic approaches to making meaning from artworks. Under this model, the art viewer may have varying degrees of expertise with major categories such as visual analysis or creative narrative and also use extrinsic or intrinsic frameworks for image deconstruction. The search for meaning is ever universal for humankind. This model is for teaching a pluralistic approach to education and promotes an ideal of encouraging a culture of dialoguing in civic education. Art educators should use this model for identifying and teaching to a variety of aesthetics strengths. Drawing from extrinsic and intrinsic frameworks for making meaning, art experiences in the classroom can be tailored to develop a curriculum that promotes and teaches diverse aesthetic meaning.
Ramaesh, Thayalini. "The effects of mouse Pax6 mutants on eye development and adult eye disease." Thesis, Heriot-Watt University, 2007. http://hdl.handle.net/10399/84.
Full textLockyer, Sharon. "An eye to offensiveness : the discourse of offence and censure in Private Eye." Thesis, Loughborough University, 2001. https://dspace.lboro.ac.uk/2134/6785.
Full textRofail, Marc. "Open globe injuries at the Royal Brisbane Hospital : 12 year audit : prognostic indicators, enucleation and quality of life /." [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19391.pdf.
Full textSatgunam, PremNandhini. "Dynamics of vergence eye movements in pre-vergence adaptation and post-vergence adaptation conditions." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1196173244.
Full textZhu, Meidong. "Development and regression of the human hyaloid system." Thesis, Sydney Medical School, 1998. http://hdl.handle.net/2123/14472.
Full textBalaram, Rakhee. "The innocent eye as myth : eye, identity and vision from surrealism to écriture féminine." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619640.
Full textCederlund, Joakim. "Eye preference in humans and its correlation with eye dominance, visual acuity and handedness." Thesis, Linköpings universitet, Biologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-129460.
Full textLara-Castillo, Nuria Tombran-Tink Joyce. "Analysis of PEDF expression in a mouse model of retinal neovascularization and autocrine effects of PEDF on retinal cells." Diss., UMK access, 2006.
Find full text"A dissertation in pharmaceutical sciences and molecular biology and biochemistry." Advisor: Joyce Tombran-Tink. Typescript. Vita. Title from "catalog record" of the print edition Description based on contents viewed Oct. 31, 2007. Includes bibliographical references (leaves 193-234). Online version of the print edition.
El-Sherbeeny, Ahmed M. "A non-invasive technique for monitoring miotic eye responses." Morgantown, W. Va. : [West Virginia University Libraries], 2001. http://etd.wvu.edu/templates/showETD.cfm?recnum=1921.
Full textTitle from document title page. Document formatted into pages; contains xi, 141 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 101-106).
Molapo, Johanna. "Eye care services for diabetic patients at Dr George Mukhari Hospital, Gauteng Province." Thesis, University of Limpopo ( Medunsa Campus ), 2011. http://hdl.handle.net/10386/419.
Full textIntroduction: Diabetes, also known as diabetes mellitus characterized by hyperglycemia is a global health problem. The World Health Organization (WHO) reports an estimated 177 million diabetics worldwide and this number is expected to double by the year 2030 mainly because of the unhealthy life styles of not doing physical exercises and eating unhealthy food. The resultant obesity is putting people at risk of developing diabetes and micro vascular complications like diabetic retinopathy that can affect a person’s eyesight. Aims and Objectives: The aim and objectives of this study were to determine the socio-economic characteristics and the level of awareness regarding the eye care services offered by the diabetic clinic at Dr George Mukhari Hospital as well as to identify the referral patterns and possible factors that may influence diabetic patients to utilize these offered services. Study methodology: Data was collected from adult diabetic patients attending the diabetic clinic at Dr George Mukhari Hospital by making use of an anonymous researcher assisted structured questionnaire. The questionnaire had sections covering the socio demographic and epidemiological information of the respondent; awareness about diabetic complications with emphasis on routine eye care; referral patterns of health professionals to the eye specialist and other barriers that the respondents experienced in attending the available eye care services. Results: Data was collected from a total of 175 respondents. The majority of the respondents were African (98%) females (75%) and older than 56 years of age (82%). Basically all the respondents (98%) did not have a medical aid and 50.3% of them were unemployed and had to make use of public transport to visit the clinic. Ninety six percent of the respondents were aware of the fact that diabetes can cause eye complications and that a routine eye test is important to prevent blindness. In this group of participants there was a referral rate of 95% which proved to be very successful because only 18% of the respondents were in need of an eye operation while the rests were treated for minor problems and then discharged. Conclusions: Based on the findings of this study all indications are that the referral patterns for diabetic patients from the diabetic clinic at the Dr George Mukhari hospital for eye testing is effective. All efforts should be made to ensure that diabetic patients go for a yearly routine eye test.
Jemc, Jennifer Colleen. "Regulation of Drosophila eye development by the transcription factors : eyes absent and Spenito." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/38996.
Full textIncludes bibliographical references.
During development of an adult organism from a fertilized embryo, signaling pathways are deployed reiteratively to regulate a variety of cellular processes, including cell proliferation, specification, differentiation, migration, survival and death. These signaling pathways do not act independently, but rather are integrated to yield desired developmental outcomes. While there are a variety of mechanisms by which signaling pathways are integrated, our work has focused on signal integration at the level of transcriptional control. Signaling pathways have been demonstrated to converge at the level of transcription, either by regulating activity of a common transcription factor and affecting its transcriptional output, or by regulating activity of distinct transcription factors, which target a common set of genes. In order to understand how signaling pathways are integrated to affect developmental outcomes, it is not only necessary to investigate the regulation of these transcription factors during development, but also it is necessary to identify their downstream transcriptional targets. In this thesis we have focused on the roles of two downstream transcriptional effectors, Eyes absent (EYA) and Spenito (NITO), in Drosophila eye development.
(cont.) EYA is a member of the retinal determination gene network (RDGN), a network of transcription factors and cofactors that when mutated result in defects in eye development, and when overexpressed can induce ectopic eye development. EYA functions as a part of a bipartite transcriptional complex, with EYA providing the transactivation function for the complex, and its cofactor Sine oculis (SO), providing the DNA-binding function. In addition to acting as a transcription cofactor, EYA also functions as a protein phosphatase, presenting a unique juxtaposition of functions and raising the question, how are these functions related? In order to examine how transcriptional activity is affected by mutating EYA phosphatase activity, we needed to identify additional transcriptional targets, given that only one target had been identified at the time these experiments began. Using microarray analysis, we compared expression profiles of wildtype tissue to those of tissue overexpressing a wildtype eya transgene. In parallel, we overexpressed a phosphatase mutant eya transgene, which allowed us to examine the overall effects of reducing phosphatase activity on transcriptional output.
(cont.) We identified 577 genes with altered expression upon overexpression of wildtype or mutant eya and confirmed 6 genes as direct targets of EYA transcriptional regulation, including string, a cell cycle regulatory gene. Stg is a particularly intriguing target, given previously characterized proliferation defects observed in tissue misexpressing eya and so. In addition, our array results suggest that mutating EYA phosphatase activity does not globally impair EYA's transcriptional output, suggesting that these functions are somewhat independent. Further analysis of transcriptional target expression and identification of targets of EYA phosphatase activity will be necessary to understand how these two functions are integrated during development. In addition, we have examined the role of SPOC family proteins, which function as effectors of Notch, Wingless and Epidermal Growth Factor Receptor (EGFR) signaling, in Drosophila eye development. Studies of these proteins in cultured cells have demonstrated their ability to function as transcriptional coregulators. In the work presented here, we have investigated the role of the small SPOC protein, Spenito (NITO), during Drosophila eye development and analyzed its relationship to a large SPOC protein, Split ends (SPEN), which is predicted to have redundant function.
(cont.) First, we characterized the eye phenotypes arising from overexpression of nito. Overexpression of nito perturbs eye development and in contrast to spen, which has been shown to act as a positive effector of EGFR signaling, appears to be a negative effector of EGFR signaling during eye development. Further genetic analysis of the relationship between spen and nito in the eye suggests they function antagonistically, possibly by targeting a common set of genes for transcriptional regulation. Further analysis of SPOC family mutants and study of the functions of these proteins at a molecular level will be necessary to understand the relationship of small and large SPOC proteins and the roles of the proteins in development and disease.
by Jennifer Colleen Jemc.
Ph.D.
Fekete, Lorand, and Maria Hagelbäck. "Gameplay experience with eye tracking." Thesis, Blekinge Tekniska Högskola, Sektionen för datavetenskap och kommunikation, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-5320.
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