Dissertations / Theses on the topic 'Extracorporeal perfusion'
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Jonsson, Ove. "Cerebral Perfusion and Metabolism during Experimental Extracorporeal Circulation." Doctoral thesis, Uppsala universitet, Anestesiologi och intensivvård, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-147486.
Full textBikhchandani, Jai. "Extracorporeal liver perfusion as liver support device : a pilot study." Thesis, University of Leicester, 2012. http://hdl.handle.net/2381/11038.
Full textNishitai, Ryuta. "Influence of Extracorporeal Porcine Liver Perfusion on Non-Human Primates : Minimizing Hemolysis Improves Subsequent Survival." Kyoto University, 2001. http://hdl.handle.net/2433/150173.
Full textChinchilla-Mendez, Joshua A. "A Computational Fluid Dynamics study of scaffolds under perfusion flow." Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/231384/1/Joshua_Chinchilla-Mendez_Thesis.pdf.
Full textSchön, Michael R. "Transplantation von Lebern nicht-herzschlagender Spender im Schweineleber-Transplantationsmodell." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2000. http://dx.doi.org/10.18452/13727.
Full textNormothermic extracorporeal liver perfusion (NELP) was studied as a means to pre-serve livers for transplantation and to reverse warm ischemic injury. For the first time we provide experimental evidence that successful transplantation after 4h of normo-thermic extracorporeal liver perfusion is possible and as reliable as 4h of cold preser-vation in University of Wisconsin solution. NELP preserves liver function completely and is capable of reversing 60 min of warm ischemic injury in non heart beating do-nors. 36 German Landrace pigs were transplanted in six groups. Group 1 animals were transplanted directly, group 2 animals after 4h of cold preservation with University of Wisconsin solution and group 3 animals following 4h of normothermic extracorporeal liver perfusion. Group 4 animals sustained 1h of warm ischemia before transplantation of the liver. In group 5 animals were transplanted following 1h of warm ischemia and 4h of cold preservation, and in group 6 after 1h of warm ischemia and 4h of normo-thermic extracorporeal liver perfusion. All animals receiving livers treated by normo-thermic extracorporeal liver perfusion survived without liver failure (group 3 and 6). In contrast, all animals in group 5 developed primary graft non-function within 24 h after transplantation. The technique of NELP holds the potential to keep a mammalian liver outside the body completely functional, possibly for longer than 4h. NELP can be used for liver preservation prior to transplantation or to utilise organs from non-heart-beating donors.
Adham, Mustapha. "Assistance hépatique par xénoperfusion extracorporelle de foie de porc : modèles d'études expérimentales et pré-cliniques." Lyon 1, 2000. http://www.theses.fr/2000LYO1T034.
Full textQuentin, Pierre. "Etude de l'effet d'une perfusion de glucose insuline potassium administree avant la circulatione xtra corporelle en chirurgie cardiaque." Lyon 1, 1988. http://www.theses.fr/1988LYO1M294.
Full textViguier, Catherine. "Libération de médiateurs d'origine endothéliale au cours d'une CEC foetale à débit pulsé : études expérimentales et implications cliniques." Lyon 1, 2000. http://www.theses.fr/2000LYO1T149.
Full textAOUIFI, ABDELLAH. "Effets de deux regimes de perfusion differents sur la glycemie et l'insulinemie au cours d'une cure de cardiopathie congenitale sous circulation extracorporelle chez l'enfant : a propos de 40 observations." Lyon 1, 1994. http://www.theses.fr/1994LYO1M300.
Full textKwasnicka, Karina Lacava. "Procedimentos básicos padronizados aplicados nos períodos pré, trans e pós-circulação extracorpórea em cães." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/10/10137/tde-31052004-145959/.
Full textThe purpose of this assay was to describe the standard basic procedures that should be followed before, during, and after cardiopulmonary bypass (CPB) in dogs, based on the existing literature and personal observations that took place in the Laboratory of Cardiothoracic Surgery, of the Surgical Department of the Faculdade de Medicina Veterinária e Zootecnia of the University of São Paulo. This assay reports how to choose the material, to prepare and to assemble the ECOBEC machine ? Braile Biomédica ? for cardiopulmonary bypass in dogs, and describes the basic procedures to start, conduct, follow up and finish it, in order to obtain a feasible technical results. Based on the literature, based on the methodology and material proposed and personal observations, it is reliable to state that this procedure can be accomplished since all paths described are followed before, during and after cardiopulmonary bypass.
Freitas, Cláudia Regina da Costa. "Avaliação do efeito da manutenção da perfusão e ventilação dos pulmões durante a circulação extracorpórea sobre a resposta inflamatória: estudo experimental." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5152/tde-01082013-143111/.
Full textBACKGROUND: Lung ischemia-reperfusion injury and the membrane oxygenator are considered important factors in the inflammatory response after cardiac surgery and cardiopulmonary bypass (CPB). Previous studies using the own lung as the oxygenator with a biventricular bypass demonstrated the beneficial effects of this technique. However, lung inflammation was not fully evaluated in this scenario. The aim of this study was to observe the impact of the exclusion of the membrane oxygenator and maintenance of lung perfusion on regional lung inflammation in pigs undergoing cardiopulmonary bypass. METHODS: Twenty-seven mechanically ventilated pigs were subjected to a thoracotomy and randomly allocated into Control (n=8), CPB (n=9) or Lung Perfusion (n=10) groups. Animals from the CPB group and Lung Perfusion group were subjected respectively to a conventional CPB or to a biventricular bypass with pulmonary ventilation and perfusion without a membrane oxygenator for 90 minutes. The systemic interleukins (ILs) were determined at baseline, after bypass and 90 min after bypass or at equivalent times in the Control group. ILs from bronchoalveolar lavage fluid (BAL) were evaluated at baseline and 90 min after bypass. Tissue samples were collected from the dorsal and ventral regions of the left lung for assessment of the number of polymorphonuclear leukocytes (PMN) per parenchyma area and edema. Data were evaluated using ANOVA and p< 0.05 was considered significant. RESULTS: The CPB group showed increased lung inflammation, with an increased PMN count compared to the Control (p<0,001) at ventral (2.8 x10-6± 0.7 x10-6 vs. 1.6 x10-6± 0.5 x10-6 , respectively) and dorsal regions (3.3 x10-6 ± 1.0 x10-6 vs. 1.9 x10-6 ± 0.5 x10-6, respectively) and to Lung Perfusion Group (p = 0.006) at ventral (2.3 x10-6 ± 0.7 x10-7) e dorsal regions (2.1 x10-6 ± 0.7 x10-6). Edema was higher in the CPB group compared to the Control at ventral and dorsal regions (2.4 x10-2± 3.5 x10-2 vs. 8.2 x10 -4± 0.2 x10-4 and 5.7 x10 -2 ± 4.3 x10-2 vs. 0.3 x10-2 ± 1.0 x10-2, respectively, p = 0.016) and increased in the dorsal region in all groups (p = 0.004). BAL IL10 and IL6 were higher in groups subjected to CPB group (41.9 ± 12.2, p = 0.010 e 239.4 ± 45.2, p<0.001, respectively) and to Lung Perfusion group (40.7 ± 12.0, p = 0.016 e 174.8 ± 61.2, p = 0.004, respectively) compared to Control group (21.0 ± 6.9 e 71.8 ± 29.8). Systemic interleukins did not differ between groups (p > 0.05). The CPB group compared to Lung Perfusion group showed a higher increase in BAL IL6 (239,4 ± 45,2 vs. 174,8 ± 61,2, p = 0,027, respectively) and in serum IL8 over time (193,1 ± 108,8 vs. 147,0 ± 59,4, p = 0,040, respectively). CONCLUSIONS: In a pig model of extracorporeal circulation, maintenance of lung perfusion and ventilation with biventricular bypass attenuates the pulmonary inflammation as compared to conventional CPB
Kuan, Kean Guan. "Extracorporeal normothermic pancreas perfusion." Thesis, 2016. http://hdl.handle.net/2440/102708.
Full textThesis (M.Phil.) (Research by Publication) -- University of Adelaide, School of Medicine, 2016.
Hosseini, Seyed Mehdi. "DIFFERENTIAL GENE EXPRESSION DURING ISCHEMIA AND REPERFUSION IN AN EXTRACORPOREAL SMALL BOWEL PERFUSION MODEL IN SWINE." Doctoral thesis, 2002. http://hdl.handle.net/11858/00-1735-0000-0006-ABFE-4.
Full textChu, Chia-Han, and 鞠嘉漢. "The Research of Included Angle on Artificial Vascular Graft End-to-SideSutured to Peripheral Artery for Extracorporeal Circulation- In Vitro Model for Right Subclavian Artery Perfusion." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/21743535187527723120.
Full text中原大學
生物醫學工程研究所
100
By using an end-to-side vascular graft sutured to the right subclavian artery or right axillary artery as an arterial oxygenated blood perfusion conduit has become an alternative way of cardiopulmonary bypass setup, especially for aortic surgery and for surgery that cannot establish arterial access at the ascending aorta. During aortic arch surgery, physiological brain protection can be achieved by selective brain perfusion (with circle of Willis) via sending the oxygenated blood through the vascular graft to the right subclavian artery then to the right common carotid artery and right vertebral artery. However, the fraction of blood flow distribution to the brain and upper limb in this graft-subclavian perfusion has always been concern to the cardiovascular surgeons and perfusionists. In this study, by using reverse engineering to reconstruct a mock of aortic arch model based a health adult computer tomography image. Through in vitro study of hydrodynamic fluid test, the fractions of blood flow distribution under different included angle (15°, 30°, 45°, 60°, 75° and 90°, six included angles) between vascular graft (8 mm diameter) and right subclavian artery were calculated. Combining with previous publicized reference values of normal blood flow from physiological human vessels, we expect to obtain the ultimate included angle for suitable blood flow distribution and pressure for organ perfusion. As a result, perfusion to whole body mode (Bi-Ac mode), an angle of 30° is the most suitable included angle to maintain physiological tissue perfusion; and selected perfusion to head and upper limbs mode (Bi-ADEFc mode), an angle of 30° is also the most suitable included angle for brain protection. If the included angle is greater than 60°, hypo-perfusion of head and hyper-perfusion of right upper limb would occur. Once this ultimate included angle is established, it not only can be applied to aortic surgery, but also can be used in minimally invasive cardiac surgery, re-do cardiac operation and surgeries with severe calcified ascending aorta, with the result of this study, increasing safety of the cardiopulmonary bypass in terms of tissue protection and reducing operational complications can be achieved.
Piquette, Dominique. "Effets de la nitroglycérine intraveineuse sur la saturation cérébrale hémisphérique pendant la chirurgie cardiaque à haut risque." Thèse, 2006. http://hdl.handle.net/1866/15369.
Full textVitorino, Catarina Lírio. "Perfusão isolada de membro : revisão da literatura e experiência do IPOFG-Lisboa em doentes com metástases em trânsito de melanoma." Master's thesis, 2020. http://hdl.handle.net/10451/46626.
Full textO melanoma maligno é um tipo de tumor cutâneo com origem nos melanócitos, localizados entre as células da camada basal da epiderme. A Perfusão Isolada do Membro (PIM) é uma técnica de circulação extracorporal, inicialmente utilizada na perfusão cardiovascular, com aplicação também na oncologia, nomeadamente no tratamento de neoplasias cutâneas, como o melanoma. Este trabalho final de mestrado foi realizado com o objetivo de compreender a abordagem de metástases em trânsito de melanoma, descrever a PIM no seu tratamento, rever a evolução histórica da técnica e os seus parâmetros de efetividade, refletir sobre as suas vantagens e limitações, assim como compreender o impacto desta terapêutica num contexto atual. Para tal foi feita uma revisão bibliográfica da literatura existente sobre a classificação e estadiamento do melanoma, para além da perfusão isolada de membro, e foi realizada a descrição da técnica com base na experiência do IPOFGLisboa. No melanoma maligno, a PIM aplica-se a doentes com estadiamento locorregional avançado, que apresentam metástases em trânsito dos membros, e tem como principais objetivos clínicos alcançar um elevado nível de remissão tumoral, evitar a amputação do membro atingido pela doença, assim como proporcionar uma melhor qualidade de vida. É uma terapêutica com mais de 50 anos de existência, apresentando elevadas taxas de resposta global com reduzidos níveis de toxicidades local e sistémica. Como principal limitação, a PIM não aumenta a sobrevivência global dos doentes e pode ocorrer recorrência das lesões em trânsito. Na era recente das terapias sistémicas para o melanoma, surge a questão provocadora sobre se a perfusão isolada de membro ainda desempenha um papel importante no tratamento de doentes com metástases em trânsito de melanoma.
Malignant melanoma is a cutaneous tumour originating from melanocytes, which are usually located in-between cells of the basal layer of the epidermis. Isolated Limb Perfusion (ILP) is a technique based on extracorporeal circulation which was initially used in cardiovascular perfusion and may have applications in oncology, namely in the treatment of some cutaneous neoplasms, such as melanoma. This paper aims to describe the role of ILP in the treatment of melanoma, to review its historical evolution its relevance and its parameters of effectiveness, to reflect on the advantages and limitations of ILP, as well as to understand the impact of this therapy in the recent age. For this purpose, a literature review and a detailed description of the technique were made based on IPOFG-Lisboa’s experience in this area. This technique is used in patients with advanced locoregional malignant melanoma, which are patients with in-transit metastasis of the limbs. The main clinical goals of ILP are to achieve a high level of tumour remission, to avoid limb amputation, as well as providing a better quality of life. It's a therapeutic practice used for more than 50 years. It shows high rates of overall response with reduced local and systemic toxicity levels. The main limitation of this technique is the fact that it does not increase patients’ overall survival and it may even lead to the recurrence of in-transit melanoma metastasis. In the recent era of systemic melanoma therapies, the provocative question arises as to whether isolated limb perfusion still plays an important role in the treatment of patients with in-transit melanoma metastasis.