Relevant bibliographies by topics / Extracellular vesicles mimetic-nanovesicles

Academic literature on the topic 'Extracellular vesicles mimetic-nanovesicles'

Author: Grafiati
Published: 10 December 2022
Last updated: 29 January 2023

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Journal articles on the topic "Extracellular vesicles mimetic-nanovesicles"

1

Nasiri Kenari, Amirmohammad, Lesley Cheng, and Andrew F. Hill. "Methods for loading therapeutics into extracellular vesicles and generating extracellular vesicles mimetic-nanovesicles." Methods 177 (May 2020): 103–13. http://dx.doi.org/10.1016/j.ymeth.2020.01.001.

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2

Martinelli, Carolina, Fabio Gabriele, Elena Dini, Francesca Carriero, Giorgia Bresciani, Bianca Slivinschi, Marco Dei Giudici, et al. "Development of Artificial Plasma Membranes Derived Nanovesicles Suitable for Drugs Encapsulation." Cells 9, no. 7 (July 6, 2020): 1626. http://dx.doi.org/10.3390/cells9071626.

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Extracellular vesicles (EVs) are considered as promising nanoparticle theranostic tools in many pathological contexts. The increasing clinical employment of therapeutic nanoparticles is contributing to the development of a new research area related to the design of artificial EVs. To this aim, different approaches have been described to develop mimetic biologically functional nanovescicles. In this paper, we suggest a simplified procedure to generate plasma membrane-derived nanovesicles with the possibility to efficiently encapsulate different drugs during their spontaneously assembly. After physical and molecular characterization by Tunable Resistive Pulse Sensing (TRPS) technology, transmission electron microscopy, and flow cytometry, as a proof of principle, we have loaded into mimetic EVs the isoquinoline alkaloid Berberine chloride and the chemotherapy compounds Temozolomide or Givinostat. We demonstrated the fully functionality of these nanoparticles in drug encapsulation and cell delivery, showing, in particular, a similar cytotoxic effect of direct cell culture administration of the anticancer drugs. In conclusion, we have documented the possibility to easily generate scalable nanovesicles with specific therapeutic cargo modifications useful in different drug delivery contexts.
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3

Ailuno, Giorgia, Sara Baldassari, Francesco Lai, Tullio Florio, and Gabriele Caviglioli. "Exosomes and Extracellular Vesicles as Emerging Theranostic Platforms in Cancer Research." Cells 9, no. 12 (December 1, 2020): 2569. http://dx.doi.org/10.3390/cells9122569.

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Exosomes are endosome-derived nanovesicles produced by healthy as well as diseased cells. Their proteic, lipidic and nucleic acid composition is related to the cell of origin, and by vehiculating bioactive molecules they are involved in cell-to-cell signaling, both in healthy and pathologic conditions. Being nano-sized, non-toxic, biocompatible, scarcely immunogenic, and possessing targeting ability and organotropism, exosomes have been proposed as nanocarriers for their potential application in diagnosis and therapy. Among the different techniques exploited for exosome isolation, the sequential ultracentrifugation/ultrafiltration method seems to be the gold standard; alternatively, commercially available kits for exosome selective precipitation from cell culture media are frequently employed. To load a drug or a detectable agent into exosomes, endogenous or exogenous loading approaches have been developed, while surface engineering procedures, such as click chemistry, hydrophobic insertion and exosome display technology, allow for obtaining actively targeted exosomes. This review reports on diagnostic or theranostic platforms based on exosomes or exosome-mimetic vesicles, highlighting the diverse preparation, loading and surface modification methods applied, and the results achieved so far.
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Ng, Chiew Yong, Li Ting Kee, Maimonah Eissa Al-Masawa, Qian Hui Lee, Thayaalini Subramaniam, David Kok, Min Hwei Ng, and Jia Xian Law. "Scalable Production of Extracellular Vesicles and Its Therapeutic Values: A Review." International Journal of Molecular Sciences 23, no. 14 (July 20, 2022): 7986. http://dx.doi.org/10.3390/ijms23147986.

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Extracellular vesicles (EVs) are minute vesicles with lipid bilayer membranes. EVs are secreted by cells for intercellular communication. Recently, EVs have received much attention, as they are rich in biological components such as nucleic acids, lipids, and proteins that play essential roles in tissue regeneration and disease modification. In addition, EVs can be developed as vaccines against cancer and infectious diseases, as the vesicle membrane has an abundance of antigenic determinants and virulent factors. EVs for therapeutic applications are typically collected from conditioned media of cultured cells. However, the number of EVs secreted by the cells is limited. Thus, it is critical to devise new strategies for the large-scale production of EVs. Here, we discussed the strategies utilized by researchers for the scalable production of EVs. Techniques such as bioreactors, mechanical stimulation, electrical stimulation, thermal stimulation, magnetic field stimulation, topographic clue, hypoxia, serum deprivation, pH modification, exposure to small molecules, exposure to nanoparticles, increasing the intracellular calcium concentration, and genetic modification have been used to improve the secretion of EVs by cultured cells. In addition, nitrogen cavitation, porous membrane extrusion, and sonication have been utilized to prepare EV-mimetic nanovesicles that share many characteristics with naturally secreted EVs. Apart from inducing EV production, these upscaling interventions have also been reported to modify the EVs’ cargo and thus their functionality and therapeutic potential. In summary, it is imperative to identify a reliable upscaling technique that can produce large quantities of EVs consistently. Ideally, the produced EVs should also possess cargo with improved therapeutic potential.
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5

Oshchepkova, Anastasiya, Oleg Markov, Evgeniy Evtushenko, Alexander Chernonosov, Elena Kiseleva, Ksenia Morozova, Vera Matveeva, Lyudmila Artemyeva, Valentin Vlassov, and Marina Zenkova. "Tropism of Extracellular Vesicles and Cell-Derived Nanovesicles to Normal and Cancer Cells: New Perspectives in Tumor-Targeted Nucleic Acid Delivery." Pharmaceutics 13, no. 11 (November 11, 2021): 1911. http://dx.doi.org/10.3390/pharmaceutics13111911.

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The main advantage of extracellular vesicles (EVs) as a drug carrier system is their low immunogenicity and internalization by mammalian cells. EVs are often considered a cell-specific delivery system, but the production of preparative amounts of EVs for therapeutic applications is challenging due to their laborious isolation and purification procedures. Alternatively, mimetic vesicles prepared from the cellular plasma membrane can be used in the same way as natural EVs. For example, a cytoskeleton-destabilizing agent, such as cytochalasin B, allows the preparation of membrane vesicles by a series of centrifugations. Here, we prepared cytochalasin-B-inducible nanovesicles (CINVs) of various cellular origins and studied their tropism in different mammalian cells. We observed that CINVs derived from human endometrial mesenchymal stem cells exhibited an enhanced affinity to epithelial cancer cells compared to myeloid, lymphoid or neuroblastoma cancer cells. The dendritic cell-derived CINVs were taken up by all studied cell lines with a similar efficiency that differed from the behavior of DC-derived EVs. The ability of cancer cells to internalize CINVs was mainly determined by the properties of recipient cells, and the cellular origin of CINVs was less important. In addition, receptor-mediated interactions were shown to be necessary for the efficient uptake of CINVs. We found that CINVs, derived from late apoptotic/necrotic cells (aCINVs) are internalized by in myelogenous (K562) 10-fold more efficiently than CINVs, and interact much less efficiently with melanocytic (B16) or epithelial (KB-3-1) cancer cells. Finally, we found that CINVs caused a temporal and reversible drop of the rate of cell division, which restored to the level of control cells with a 24 h delay.
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6

Anita, Limanjaya, Guo Nan Yin, Soon-Sun Hong, Ju-Hee Kang, Yong Song Gho, Jun-Kyu Suh, and Ji-Kan Ryu. "Pericyte-derived extracellular vesicle-mimetic nanovesicles ameliorate erectile dysfunction via lipocalin 2 in diabetic mice." International Journal of Biological Sciences 18, no. 9 (2022): 3653–67. http://dx.doi.org/10.7150/ijbs.72243.

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7

Kim, Yoon Seon, Gyeongyun Go, Chul-Won Yun, Ji-Hye Yea, Sungtae Yoon, Su-Yeon Han, Gaeun Lee, Mi-Young Lee, and Sang Hun Lee. "Topical Administration of Melatonin-Loaded Extracellular Vesicle-Mimetic Nanovesicles Improves 2,4-Dinitrofluorobenzene-Induced Atopic Dermatitis." Biomolecules 11, no. 10 (October 2, 2021): 1450. http://dx.doi.org/10.3390/biom11101450.

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Atopic dermatitis (AD) is caused by multiple factors that trigger chronic skin inflammation, including a defective skin barrier, immune cell activation, and microbial exposure. Although melatonin has an excellent biosafety profile and a potential to treat AD, there is limited clinical evidence from controlled trials that support the use of melatonin as an AD treatment. The delivery of melatonin via the transdermal delivery system is also a challenge in designing melatonin-based AD treatments. In this study, we generated melatonin-loaded extracellular vesicle-mimetic nanoparticles (MelaNVs) to improve the transdermal delivery of melatonin and to evaluate their therapeutic potential in AD. The MelaNVs were spherical nanoparticles with an average size of 100 nm, which is the optimal size for the transdermal delivery of drugs. MelaNVs showed anti-inflammatory effects by suppressing the release of TNF-α and β-hexosaminidase in LPS-treated RAW264.7 cells and compound 48/80-treated RBL-2H3 cells, respectively. MelaNVs showed a superior suppressive effect compared to an equivalent concentration of free melatonin. Treating a 2,4-dinitrofluorobenzene (DNCB)-induced AD-like mouse model with MelaNVs improved AD by suppressing local inflammation, mast cell infiltration, and fibrosis. In addition, MelaNVs effectively suppressed serum IgE levels and regulated serum IFN-γ and IL-4 levels. Taken together, these results suggest that MelaNVs are novel and efficient transdermal delivery systems of melatonin and that MelaNVs can be used as a treatment to improve AD.
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8

Tao, Shi-Cong, Bi-Yu Rui, Qi-Yang Wang, Ding Zhou, Yang Zhang, and Shang-Chun Guo. "Extracellular vesicle-mimetic nanovesicles transport LncRNA-H19 as competing endogenous RNA for the treatment of diabetic wounds." Drug Delivery 25, no. 1 (January 1, 2018): 241–55. http://dx.doi.org/10.1080/10717544.2018.1425774.

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9

Oh, Keunhee, Sae Rom Kim, Dae-Kyum Kim, Myung Won Seo, Changjin Lee, Hak Mo Lee, Ju-Eun Oh, et al. "In Vivo Differentiation of Therapeutic Insulin-Producing Cells from Bone Marrow Cells via Extracellular Vesicle-Mimetic Nanovesicles." ACS Nano 9, no. 12 (November 3, 2015): 11718–27. http://dx.doi.org/10.1021/acsnano.5b02997.

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10

Yin, Guo Nan, Soo-Hwan Park, Jiyeon Ock, Min-Ji Choi, Anita Limanjaya, Kalyan Ghatak, Kang-Moon Song, et al. "Pericyte-Derived Extracellular Vesicle–Mimetic Nanovesicles Restore Erectile Function by Enhancing Neurovascular Regeneration in a Mouse Model of Cavernous Nerve Injury." Journal of Sexual Medicine 17, no. 11 (November 2020): 2118–28. http://dx.doi.org/10.1016/j.jsxm.2020.07.083.

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