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Journal articles on the topic 'Experimental medicine'

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Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2024

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1

Ottaviani, Palma T. "Physiology and Experimental Medicine." Pediatric Drugs 11, no. 1 (2009): 69–71. http://dx.doi.org/10.2165/0148581-200911010-00023.

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2

Dawson, Gerard R., and Guy Goodwin. "Experimental medicine in psychiatry." Journal of Psychopharmacology 19, no. 6 (November 2005): 565–66. http://dx.doi.org/10.1177/0269881105059935.

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3

Park, Jang-Kyung, and Dong-Il Kim. "Modernization Trends of Infertility Treatment of Traditional Korean Medicine." Evidence-Based Complementary and Alternative Medicine 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/4835912.

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Despite the development of assisted reproductive technology (ART), it is difficult to increase the implantation rate. In Korea, Traditional Korean Medicine, including herbal medicine, is an important component of infertility treatment. Korean medical doctors who are treating infertility often use herbal medicine to promote implantation. In this article, as one of the research works on modernization of Traditional Korean Medicine, we investigated the experimental studies to clarify the effects of herbal medicines that are traditionally used to promote pregnancy. We searched for experimental studies over the past 10 years of improvement of endometrial receptivity in herbal medicine using six domestic and international sites. We analyzed 11 studies that meet the selection criteria. We found that herbal medicines demonstrably improved endometrial receptivity and increased pregnancy rates.
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4

Lavelle, Séan M. "Suggested curriculum for experimental medicine." Technology and Health Care 20, no. 3 (June 25, 2012): 237–38. http://dx.doi.org/10.3233/thc-2012-0666.

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5

Abdel-Halim, RabieE. "Experimental medicine 1000 years ago." Urology Annals 3, no. 2 (2011): 55. http://dx.doi.org/10.4103/0974-7796.82168.

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6

Keith, Ronald Mac. "THE CHILD AND EXPERIMENTAL MEDICINE." Developmental Medicine & Child Neurology 6, no. 3 (November 12, 2008): 229–30. http://dx.doi.org/10.1111/j.1469-8749.1964.tb10781.x.

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7

Romano, G. "Gene transfer in experimental medicine." Drug News & Perspectives 16, no. 5 (2003): 267. http://dx.doi.org/10.1358/dnp.2003.16.5.829314.

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8

Insel, Thomas R. "The NIMH experimental medicine initiative." World Psychiatry 14, no. 2 (June 2015): 151–53. http://dx.doi.org/10.1002/wps.20227.

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9

Bellavite, Paolo, Riccardo Ortolani, and Anita Conforti. "Immunology and Homeopathy. 3. Experimental Studies on Animal Models." Evidence-Based Complementary and Alternative Medicine 3, no. 2 (2006): 171–86. http://dx.doi.org/10.1093/ecam/nel016.

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A search of the literature and the experiments carried out by the authors of this review show that there are a number of animal models where the effect of homeopathic dilutions or the principles of homeopathic medicine have been tested. The results relate to the immunostimulation by ultralow doses of antigens, the immunological models of the ‘simile’, the regulation of acute or chronic inflammatory processes and the use of homeopathic medicines in farming. The models utilized by different research groups are extremely etherogeneous and differ as the test medicines, the dilutions and the outcomes are concerned. Some experimental lines, particularly those utilizing mice models of immunomodulation and anti-inflammatory effects of homeopathic complex formulations, give support to a real effect of homeopathic high dilutions in animals, but often these data are of preliminary nature and have not been independently replicated. The evidence emerging from animal models is supporting the traditional ‘simile’ rule, according to which ultralow doses of compounds, that in high doses are pathogenic, may have paradoxically a protective or curative effect. Despite a few encouraging observational studies, the effectiveness of the homeopathic prevention or therapy of infections in veterinary medicine is not sufficiently supported by randomized and controlled trials.
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10

Bellanti, Francesco, Gianluigi Vendemiale, and Gaetano Serviddio. "Redox experimental medicine and liver regeneration." Redox Experimental Medicine 2022, no. 1 (July 1, 2022): R69—R82. http://dx.doi.org/10.1530/rem-22-0008.

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The liver is characterized by unique regenerative properties to restore its mass and function after a partial loss. Hepatic regeneration arises after resection or following acute and chronic injuries. Resection and acute liver damage normally induce a regenerative process characterized by phenotypic fidelity, in which each cell type promotes its own replication and replacement. This process fails in chronic liver damage, where trans-differentiation of parenchymal cells or activation of facultative progenitors occurs. Both liver resection and acute/chronic damages alter redox homeostasis, as a consequence of blood flow changes, hypoxia, metabolism modification, and activation of inflammatory response. Even though formerly described as ‘oxidative stress’, altered redox homeostasis leads to the fine regulation of several pathways involved in liver regeneration, including the proliferation of parenchymal cells, trans-differentiation, and activation of facultative progenitors. Several redox-dependent transcription factors and pathways implicated in the regenerative process of the liver were described, but pre-clinical experiments using different antioxidants were not fully conclusive. Even though accurate study designs to define appropriate dosages, treatment duration, and routes of administration are required, modulation of redox-dependent molecular pathways to enhance liver regeneration is even more intriguing. Preliminary studies focused on the identification of these targets will pave the way for viable therapies to be tested in clinical trials.
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11

Brodie, D. A., and K. Stopani. "Experimental Ethics in Sports Medicine Research." Sports Medicine 9, no. 3 (March 1990): 143–50. http://dx.doi.org/10.2165/00007256-199009030-00002.

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12

Balber, Theresa, Loan Tran, Katarína Benčurová, Julia Raitanen, Gerda Egger, and Markus Mitterhauser. "Experimental Nuclear Medicine Meets Tumor Biology." Pharmaceuticals 15, no. 2 (February 14, 2022): 227. http://dx.doi.org/10.3390/ph15020227.

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Personalized treatment of cancer patients demands specific and validated biomarkers for tumor diagnosis and therapy. The development and validation of such require translational preclinical models that recapitulate human diseases as accurately as possible. Moreover, there is a need for convergence of different (pre)clinical disciplines that openly share their knowledge and methodologies. This review sheds light on the differential perception of biomarkers and gives an overview of currently used models in tracer development and approaches for biomarker discovery.
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13

Dawson, Gerard R., Colin T. Dourish, and Guy M. Goodwin. "Special issue on CNS experimental medicine." Journal of Psychopharmacology 25, no. 9 (September 2011): 1145–47. http://dx.doi.org/10.1177/0269881111415342.

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14

Blackshaw, L. A. "Visceral pain readouts in experimental medicine." Neurogastroenterology & Motility 24, no. 10 (September 12, 2012): 891–94. http://dx.doi.org/10.1111/nmo.12014.

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15

Ro, Kevin, John L. Cameron, and Michael W. Yeh. "The Hunterian Laboratory of Experimental Medicine." Annals of Surgery 253, no. 5 (May 2011): 1042–48. http://dx.doi.org/10.1097/sla.0b013e31821598c9.

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16

Thompson, S. J. "Advances in experimental medicine and biology." Annals of the Rheumatic Diseases 55, no. 11 (November 1, 1996): 796–97. http://dx.doi.org/10.1136/ard.55.11.796-c.

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17

Lunt, G. G. "Advances in Experimental Medicine and Biology." Neurochemistry International 8, no. 3 (January 1986): 443. http://dx.doi.org/10.1016/0197-0186(86)90020-3.

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18

Dombovy, M. L. "Advances in Experimental Medicine and Biology." Archives of Neurology 51, no. 12 (December 1, 1994): 1177–78. http://dx.doi.org/10.1001/archneur.1994.00540240021005.

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19

Dei, Andrea. "Experimental Evidence Supports New Perspectives in Homeopathy." Homeopathy 109, no. 04 (March 2, 2020): 256–60. http://dx.doi.org/10.1055/s-0040-1701445.

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AbstractThe contentious debate between homeopathy and orthodox medicine has been due to the fact that homeopathy is founded on a heuristic philosophy that is not justified by contemporary scientific evidence. In this context, however, two pillars of the method, that is, serial dilution and succussion, are poorly understood in orthodox pharmacology. The experimental data collected in the last 10 years, by means of electronic microscopy, electron diffraction and DNA arrays investigations, are consistent with the presence of nanoparticles (nanoassociates) in homeopathic medicines and seem to provide a coherent view of the essence of the homeopathy discipline, superseding all previous speculative interpretations. An acceptance of this new evidence is here suggested to remove, in principle, the barrier that separates the conventional and homeopathic therapeutic methods, and to offer new and important perspectives on future health care.
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20

Semenov, V. V., V. A. Glumova, and V. V. Trusov. "Anabolic steroids in experimental and clinical medicine." Kazan medical journal 66, no. 1 (February 15, 1985): 48–50. http://dx.doi.org/10.17816/kazmj60547.

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Drugs that affect metabolic processes in the body include anabolic steroid hormones, synthetic analogs of male sex hormones, devoid of sexual activity, but retaining a positive effect on growth, body weight, myotropic activity and nitrogen balance.
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21

Hebden, Jeremy C., Simon R. Arridge, and David T. Delpy. "Optical imaging in medicine: I. Experimental techniques." Physics in Medicine and Biology 42, no. 5 (May 1, 1997): 825–40. http://dx.doi.org/10.1088/0031-9155/42/5/007.

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22

Raper, Jr., James E., and Lynn Kasner Morgan. "Experimental Therapeutics in Addiction Medicine, Part I." Journal of Addictive Diseases 13, no. 3 (January 27, 1995): 101–13. http://dx.doi.org/10.1300/j069v13n03_08.

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23

Raper, Jr., James E., and Lynn Kasner Morgan. "Experimental Therapeutics in Addiction Medicine, Part II." Journal of Addictive Diseases 13, no. 4 (February 3, 1995): 217–30. http://dx.doi.org/10.1300/j069v13n04_09.

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24

Klevay, L. M., B. R. Bistrian, C. R. Fleming, and C. G. Neumann. "Hair analysis in clinical and experimental medicine." American Journal of Clinical Nutrition 46, no. 2 (August 1, 1987): 233–36. http://dx.doi.org/10.1093/ajcn/46.2.233.

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25

McCall, Becky. "Funding: MRC boosts experimental medicine in humans." Lancet 384, no. 9956 (November 2014): e57. http://dx.doi.org/10.1016/s0140-6736(14)62075-4.

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26

Dammacco, Franco. "Clinical and experimental medicine: innovation and continuity." Clinical and Experimental Medicine 12, no. 1 (February 14, 2012): 1–2. http://dx.doi.org/10.1007/s10238-012-0179-4.

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27

Etzel, Joseph V. "Book Review: Experimental Therapeutics in Addiction Medicine." Annals of Pharmacotherapy 29, no. 12 (December 1995): 1305–6. http://dx.doi.org/10.1177/106002809502901232.

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28

Mendes, Aysha. "Highlighting experimental treatment advances in cardiovascular medicine." Journal of Prescribing Practice 2, no. 2 (February 2, 2020): 62–63. http://dx.doi.org/10.12968/jprp.2020.2.2.62.

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29

The Lancet. "Translational research and experimental medicine in 2012." Lancet 379, no. 9810 (January 2012): 1. http://dx.doi.org/10.1016/s0140-6736(12)60002-6.

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30

Waldman, Scott A., Walter K. Kraft, Timothy J. Nelson, and Andre Terzic. "Experimental Therapeutics: A Paradigm for Personalized Medicine." Clinical and Translational Science 2, no. 6 (December 2009): 436–38. http://dx.doi.org/10.1111/j.1752-8062.2009.00146.x.

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31

Ellis, Harold. "Claude Bernard: a founder of experimental medicine." British Journal of Hospital Medicine 74, no. 8 (August 2013): 474. http://dx.doi.org/10.12968/hmed.2013.74.8.474.

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32

Goodman, Steven R. "The Experimental Biology and Medicine and Royal Society of Medicine Press partnership." Experimental Biology and Medicine 235, no. 1 (January 2010): 1–2. http://dx.doi.org/10.1258/ebm.2009.009e01.

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33

Guo, Jing, Yabin Gao, Yaoxian Wang, Wei Jing Liu, Jingwei Zhou, and Zhen Wang. "Application of Herbal Medicines with Heat-Clearing Property to Anti-Microinflammation in the Treatment of Diabetic Kidney Disease." Evidence-Based Complementary and Alternative Medicine 2019 (June 2, 2019): 1–6. http://dx.doi.org/10.1155/2019/6174350.

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Diabetic kidney disease (DKD) is a global pandemic, and microinflammation has been reported as an important pathogenic factor of DKD. Traditional Chinese Medicine (TCM) has been used in the treatment of DKD for thousands of years, and modern Chinese medicine studies have found that herbal medicines with heat-clearing property have a curative anti-inflammation effect in DKD. This article reviews the new clinical and experimental progress made in herbal medicines with heat-clearing property, in the treatment of DKD, as well as their safety aspects.
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34

Rumyantsev, P., A. Trukhin, K. Sergunova, Ya Sirota, N. Makarova, A. Bubnov, D. Semenov, and E. Ahmad. "Phantoms for Nuclear Medicine." Medical Radiology and radiation safety 65, no. 2 (April 29, 2020): 62–67. http://dx.doi.org/10.12737/1024-6177-2020-65-2-62-67.

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The nuclear medicine phantom development is based on the step by step description of the computational and experimental biological object model. Computational phantoms are used for geometry of the object description and simulate physics of particle interactions with matter, while experimental phantoms are used for quality control tests and standardization of functional research protocols. Common examples are the dosimetry planning of radionuclide therapy and post-therapeutic scintigraphy with 131I. This review provides a list of methods for computational and experimental phantoms. Examples of existing phantoms created for the nuclear medicine tasks are also given.
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35

Shiina and Blancher. "The Cynomolgus Macaque MHC Polymorphism in Experimental Medicine." Cells 8, no. 9 (August 26, 2019): 978. http://dx.doi.org/10.3390/cells8090978.

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Among the non-human primates used in experimental medicine, cynomolgus macaques (Macaca fascicularis hereafter referred to as Mafa) are increasingly selected for the ease with which they are maintained and bred in captivity. Macaques belong to Old World monkeys and are phylogenetically much closer to humans than rodents, which are still the most frequently used animal model. Our understanding of the Mafa genome has progressed rapidly in recent years and has greatly benefited from the latest technical advances in molecular genetics. Cynomolgus macaques are widespread in Southeast Asia and numerous studies have shown a distinct genetic differentiation of continental and island populations. The major histocompatibility complex of cynomolgus macaque (Mafa MHC) is organized in the same way as that of human, but it differs from the latter by its high degree of classical class I gene duplication. Human polymorphic MHC regions play a pivotal role in allograft transplantation and have been associated with more than 100 diseases and/or phenotypes. The Mafa MHC polymorphism similarly plays a crucial role in experimental allografts of organs and stem cells. Experimental results show that the Mafa MHC class I and II regions influence the ability to mount an immune response against infectious pathogens and vaccines. MHC also affects cynomolgus macaque reproduction and impacts on numerous biological parameters. This review describes the Mafa MHC polymorphism and the methods currently used to characterize it. We discuss some of the major areas of experimental medicine where an effect induced by MHC polymorphism has been demonstrated.
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36

Bardey, David, Samuel Kembou, and Bruno Ventelou. "Physicians’ incentives to adopt personalised medicine: Experimental evidence." Journal of Economic Behavior & Organization 191 (November 2021): 686–713. http://dx.doi.org/10.1016/j.jebo.2021.07.037.

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37

De Block, Andreas, and Kristien Hens. "A plea for an experimental philosophy of medicine." Theoretical Medicine and Bioethics 42, no. 3-4 (August 2021): 81–89. http://dx.doi.org/10.1007/s11017-021-09551-2.

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38

Chauhan, Nitin, Zonghang Zhao, Phil A. Barber, and Alastair M. Buchan. "Lessons in experimental ischemia for clinical stroke medicine." Current Opinion in Neurology 16, no. 1 (February 2003): 65–71. http://dx.doi.org/10.1097/00019052-200302000-00009.

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39

Katsuki, Motoya. "A Novel Humanized Animal Model for Experimental Medicine." Japanese Journal of Pharmacology 67 (1995): 4. http://dx.doi.org/10.1016/s0021-5198(19)35549-0.

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40

Marchal, G. "Advances in experimental medicine & biology, volume 388." Biochimie 79, no. 1 (January 1997): 63. http://dx.doi.org/10.1016/s0300-9084(97)87626-2.

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41

Mehta, M. "S.10.02 Experimental medicine with phMRI: study designs." European Neuropsychopharmacology 25 (September 2015): S124—S125. http://dx.doi.org/10.1016/s0924-977x(15)30054-7.

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42

Minet, Olaf, Jürgen Beuthan, and Urszula Zabarylo. "Deconvolution techniques for experimental optical imaging in medicine." Medical Laser Application 23, no. 4 (November 2008): 216–25. http://dx.doi.org/10.1016/j.mla.2008.07.001.

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43

Fayers, Peter M. "Randomization in clinical trials and experimental molecular medicine." Molecular Medicine Today 2, no. 9 (September 1996): 366–68. http://dx.doi.org/10.1016/s1357-4310(96)20023-1.

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44

Verheyen, Julia, Peter Kohl, and Rémi Peyronnet. "The Institute for Experimental Cardiovascular Medicine in Freiburg." Biophysical Reviews 11, no. 5 (September 16, 2019): 675–77. http://dx.doi.org/10.1007/s12551-019-00593-4.

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45

Lücking, Christoph B. "Advances in Experimental Medicine and Biology, Vol 541." Journal of Neurology 252, no. 11 (November 2005): 1425. http://dx.doi.org/10.1007/s00415-005-0004-z.

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46

Littman, Bruce H., and Stephen A. Williams. "The ultimate model organism: progress in experimental medicine." Nature Reviews Drug Discovery 4, no. 8 (August 2005): 631–38. http://dx.doi.org/10.1038/nrd1800.

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47

Niczyporuk, M. "Rat skin as an experimental model in medicine." Progress in Health Sciences 8, no. 2 (December 31, 2018): 223–28. http://dx.doi.org/10.5604/01.3001.0012.8351.

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Scientific experiments due to safety and ethical limitations regarding research human are often based on animal models. Rats are laboratory animals which are commonly used for these purposes. It should be remembered that morphologi- cal and functional differences between rat skin and human skin may refer to the correct interpretation of scientific results.
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48

Nutton, V. "PORTRAITS OF SCIENCE: Logic, Learning, and Experimental Medicine." Science 295, no. 5556 (February 1, 2002): 800–801. http://dx.doi.org/10.1126/science.1066244.

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49

Prudden, Holly, Roger Tatoud, Cathy Slack, Robin Shattock, Pervin Anklesaria, Linda-Gail Bekker, and Susan Buchbinder. "Experimental Medicine for HIV Vaccine Research and Development." Vaccines 11, no. 5 (May 11, 2023): 970. http://dx.doi.org/10.3390/vaccines11050970.

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The development of safe and effective HIV vaccines has been a scientific challenge for more than 40 years. Despite disappointing results from efficacy clinical trials, much has been learnt from years of research and development. In a rapidly evolving HIV prevention landscape, swift evaluation of multiple vaccine approaches eliciting cross-reactive humoral and cellular responses is needed to ensure the development of efficacious vaccine candidates. To contain increasing costs, innovative clinical research methods are required. Experimental medicine has the potential to accelerate vaccine discovery by iterating early stages of clinical testing faster and by selecting the most promising immunogen combinations for further clinical evaluation. As part of its mission to unite diverse stakeholders involved in the response to the HIV epidemic, the Global HIV Vaccine Enterprise at IAS—the International AIDS Society—hosted a series of online events between January and September 2022 to discuss the merits and challenges of experimental medicine studies to accelerate the development of safe and effective HIV vaccines. This report summarizes key questions and discussions across the series of events, which brought together scientists, policy makers, community stakeholders, advocates, bioethicists, and funders.
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50

Luo, Yilin. "Research progress of traditional Chinese medicine and its monomer compounds and extracts on alcoholic gastric injury." BIO Web of Conferences 111 (2024): 03022. http://dx.doi.org/10.1051/bioconf/202411103022.

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Alcoholic gastric injury is a gastric disease caused by excessive intake of alcohol directly stimulating the gastric mucosa or alcohol entering the gastric wall after the dissolution of lipids. Traditional Chinese medicine has a long history in the treatment of alcoholic gastric injury, and has the characteristics of high cure rate, low recurrence rate and small adverse reactions. This article reviews the experimental research and clinical application of traditional Chinese medicine, single compounds of Chinese herbs, traditional Chinese medicine extracts and traditional Chinese medicine compounds in preventing and treating alcoholic gastric injury. This article reviews the effectiveness of herbal medicines for the treatment of alcoholic gastric injury, and their mechanisms of action is presented to provide a reference for further research on anti-alcoholic gastric injury herbal medicines.
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