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Lundkvist, Robert. "Expanding the use of contract inspections in construction : An approach to inter-project knowledge diffusion?" Licentiate thesis, Luleå tekniska universitet, Byggkonstruktion och -produktion, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-26285.
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This licentiate thesis presents a taxonomic approach to classification of defect information in construction projects. A conceptual model, based in a frame of reference consisting of the concepts of Continuous Improvement, Performance Measurement, Knowledge Management, as well as the current Quality Management regime of the industry helps to understand how the use of Contract Inspections can be developed towards facilitating inter-project knowledge diffusion and continuous improvement in construction.Three research questions were formulated:RQ I:How is information from inspection reports currently used?RQ II:How could information from inspection reports be utilised further?RQ III:How should information from inspection reports be structured and codified, to enable storage and future data analysis to facilitate continuous improvement?Qualitative as well as quantitative data has been collected in three different studies. In the first contractors were surveyed through a questionnaire about their use of different suggested experience feedback concepts, such as contract inspections. In the second other project participants than contractors was an interviewed, asking them how they use inspections and how the current usage could be extended. In the third study, a single case study about the inspection activities in one construction project, the purpose was to analyse the method and results of Pre- and Final Inspections. These results were interpreted through classification theory. It is further suggested how inspection data could be enhanced for the purpose of database storing, transforming, and easy access.The thesis concludes that both contractors and the other project roles currently use and view inspections as they are prompted in the General Conditions (AB 04), i.e. as an activity that document what defects there are for the contractor to rectify. Several companies have started to store inspection reports on project-dedicated servers, a routine that is thought to enhance the access to information to some extent. Several respondents have also introduced the compilation of defect statistics.Except automating the compiling of descriptive defect statistics, a system for managing inspection information, giving the widest access to the information about previously experienced defects, is expected to serve a Continuous Improvement process with input for identifying reoccurring problems in the production process. This system could as well be utilised for giving performance feedback to contractors and suppliers. Through continual surveying of the performance of current projects, the performance of the production process can be monitored. Based on the analysed reports, and the literature on taxonomy, the conclusions for RQ III identifies 15 different types of data tags, or types of information, that should be used as structure for the defects’ information: Unique Project Identifier, Unique Defect Identifier, Inspection Identifier, Responsibility, Defect Serial Number, Floor level, BSAB 96 Space Code, BSAB Object code, Defect type, Defect description, Rectification measure, Flag for Safety Issue, Cause, Date logging, and Photos.Future research should focus on the validation of the proposed model and system, suggested through case studies.Den här licentiatavhandlingen presenterar ett taxonomiskt upplägg för att klassificera informationen om de fel som uppkommer i byggprojekt. Tre forskningsfrågor formulerades:FF I: Hur används informationen i besiktningsutlåtandena i nuläget?FF II: Hur kan användningen av informationen i besiktningsutlåtandenavidareutvecklas?FF III: Hur bör informationen från utlåtandena struktureras och kodifieras, för att tillåta lagring samt framtida dataanalys, till hjälp för Ständiga förbättringar?Kvalitativ, såväl som kvantitativ, data har samlats in över tre olika studier. I den första tillfrågades Sveriges byggentreprenörer genom en enkät hur de använder olika typer av föreslagna erfarenhetsåterföringsaktiviteter, t.ex. entreprenadbesiktningar. I den andra studien intervjuades övriga projektroller om hur de använder besiktningsinformationen, samt hur det nuvarande användandet kan utökas till andra områden. I den tredje studien, en singel-fallstudie över besiktningsaktiviteterna i ett större byggprojekt, analyserades och klassificerades informationen om felen från projektets besiktningsutlåtanden utifrån det svenska klassificeringssystemet för byggbranschen, BSAB 96.Resultaten visar att alla tillfrågade projektroller idag har den syn på besiktningar som de är tänkta från början, som de presenteras i AB 04, d.v.s. som en aktivitet som dokumenterar de fel som finns i ett projekt och som entreprenören måste åtgärda innan besiktningen blir godkänd. Ett flertal företag har dock börjat spara de färdiga besiktningsutlåtandena på projektportaler, en rutin som torde öka möjligheten till spridning av besiktningsinformationen något. Några respondenter har även börjat med att sammanställa enklare statistik över fel inom produktionen i företaget. Baserat på de analyserade besiktningsutlåtandena och litteraturen om taxonomier så föreslås även 15 olika klassificeringsbegrepp, med syftet att förädla informationen om felen i utlåtandena: Unikt Projekt-ID, Unikt Fel-ID, Besiktnings-ID, Ansvar, Löpnummer fel, Våning, BSAB 96 Utrymme-kod, BSAB element/objekt-kod, Feltyp, Felbeskrivning, Åtgärd, Flagga för säkerhetsproblem, Orsak (förslagsvis grundorsaksanalys), datumloggning och foton.Förutom att kunna automatisera statistikframställning, så ger en systemlösning för att hantera besiktningsinformation möjligheter till att kunna sprida informationen om tidigare producerade fel. Systemet antas kunna förse en process för Ständiga förbättringar med input för att kunna identifiera systematiskt återkommande fel och därav problemområden för förbättringsorganisation att arbeta med.Baserat på idéerna om Ständiga förbättringar, prestationsmätningar och Knowledge Management utvecklades en modell för hur arbetet med entreprenad-besiktningar kan utvecklas till att kunna hjälpa vid med kunskapsspridning mellan projekt samt Ständiga förbättringar. Framtida forskning bör framförallt fokusera på att validera den föreslagna modellen och systemet, förslagsvis genom fallstudier.
Godkänd; 2011; 20111115 (roblun); LICENTIATSEMINARIUM Ämnesområde: Byggproduktion/Construction Engineering Examinator: Professor Thomas Olofsson, Institutionen för samhällsbyggnad och naturresurser, Luleå tekniska universitet Diskutant: Filosofie doktor Kajsa Simu, NCC Construction, Luleå Tid: Fredag den 16 december 2011 kl 10.00 Plats: E246, Luleå tekniska universitet
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Ratute, Ashley. "Expanding social justice knowledge with sweatshop history." [Ames, Iowa : Iowa State University], 2010. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1476340.
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Griffith, Alan. "Expanding knowledge and practice of construction management systems and procedures." Thesis, Sheffield Hallam University, 2006. http://shura.shu.ac.uk/20163/.
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This submission is a highly focused collection of research-based and scholarly publications in the specialist field of Construction Management. Emphasis is placed on management systems and procedures involved in the procurement and production phases of the total building process. A coherent, original, independent and significant contribution to the advancement and application of knowledge has been made through applied research and dissemination of findings to academic peers, construction industry professionals and students in higher education. This has been achieved through: academic, professional and research-based textbooks; research monographs; refereed papers in learned journals; refereed papers to premier national and international conferences; and papers to foremost construction industry professional institutions. Textbooks have been published by Macmillan, Thomas-Telford in collaboration with the Engineering and Physical Sciences Research Council (EPSRC), Longman and Palgrave with three commissioned by and contributing to the Chartered Institute of Building (CIOB) 'Education Framework' for construction industry. Peer-reviewed papers have been published by eminent journals based within the UK, North America, Australia, Hong Kong and China whilst refereed conference papers have been published both in the UK and internationally at leading research symposia. Among the refereed journal and conference papers presented, a number have merited prestigious awards reflecting "the outstanding contribution to research knowledge and communication within the construction industry" (ciob, 1988) and in recognition of "making a practical and lasting contribution towards the improvement of standards in building practice and education in building"(CIOB, 2004).This submission reflects a distinguished level of dissemination of applied research and scholarship over a twenty year period. The body of work presented has established a highly significant and authoritative contribution to the better understanding of construction management systems andprocedures. Furthermore, it has influenced, where applicable, thinking and practice within the subject field within research groups, higher education, the professions and the construction industry.
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Garza, Moreno Laura. "Expanding knowledge on Mycoplasma hyopneumoniae gilt acclimation, vaccination and genetic variability." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/667223.
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Esta Tesis Doctoral está constituida por tres estudios. El primer estudio consistió en identificar las estrategias actuales de adaptación de la reposición frente M. hyopneumoniae utilizadas en las granjas porcinas de Europa. Para alcanzar este objetivo, se diseñó un cuestionario centrado en las diferentes características de la explotación, la reposición y el proceso de adaptación. Los resultados obtenidos indicaron que la vacunación frente M. hyopneumoniae con múltiples dosis, fue la estrategia más utilizada, sola o en combinación con otros métodos, para la adaptación de la reposición frente a este patógeno en Europa. No obstante, el efecto de la vacunación de la reposición se desconocía. Para conocer el efecto de la vacunación de la reposición frente a M. hyopneumoniae, se evaluaron diferentes programas vacunales en el segundo estudio de esta Tesis. Para ello, se seleccionaron 180 cerdas negativas frente a M. hyopneumoniae en la unidad de adaptación de una granja positiva a M. hyopneumoniae y se distribuyeron según el programa vacunal en tres grupos: (A) cuatro dosis de una vacuna comercial contra M. hyopneumoniae a las 2, 4, 6 y 8 semanas tras la entrada (spe) en la adaptación, (B) dos dosis de vacuna a las 2 y 6, y dos inyecciones de solución salina tamponada con fosfato (PBS) a las 4 y 8 spe, y (C) cuatro dosis de PBS a los mismos tiempos. Los grupos vacunados (A y B) mostraron una proporción significativamente más baja de nulíparas excretoras y niveles de anticuerpos más elevados en comparación con el grupo no vacunado. No se encontraron diferencias significativas entre los protocolos de vacunación con cuatro o dos dosis en términos de excreción y niveles de anticuerpos Respecto a los lechones al destete, todos fueron negativos a M. hyopneumoniae por PCR en tiempo real, independientemente del programa de vacunación administrado a sus madres. Por otro lado, la proporción de lechones seropositivos y los niveles de anticuerpos fueron mayores en los lechones provenientes de los grupos vacunados. Este estudio demostró por primera vez que la vacunación de la reposición frente a M. hyopneumoniae puede ser una herramienta eficaz para reducir la presión de infección y la variabilidad de M. hyopneumoniae en lotes de reposición, así como proporcionar una inmunidad humoral a largo plazo para la reposición y sus lechones. El tercer estudio de esta Tesis tuvo como objetivo evaluar la variabilidad genética de M. hyopneumoniae en cerdos no vacunados y vacunados que presentaban lesiones pulmonares asociadas a M. hyopneumoniae en los mataderos. Asimismo, se evaluó la variabilidad genética de las vacunas comerciales frente a M. hyopneumoniae utilizadas en las granjas vacunadas. Para lograr este objetivo, se seleccionaron diez granjas de cerdos de engorde vacunadas y diez no vacunadas, positivas a M. hyopneumoniae. En el matadero, se evaluaron las lesiones pulmonares compatibles con M. hyopneumoniae de un lote por granja y se recogieron muestras de los tres pulmones con la lesión más extensa. Las muestras positivas a M. hyopneumoniae por PCR se genotiparon contando el número variable de repeticiones en tándem (del inglés, variable number of tandem repeats) en dos (P97, P146) o cuatro genes (P97, P146, H1 y H5) y se les asignó un perfil de tipificación (TP) de M. hyopneumoniae. Se detectó una elevada variabilidad entre granjas, mientras que la variabilidad dentro de las granjas fue limitada usando dos o cuatro genes. Curiosamente, Cuanto mayor fue el número de genes estudiados, mayor variabilidad. No obstante, se detectó un TP por pulmón y los TPs detectados en cerdos de granjas vacunadas fueron diferentes de la cepa vacunal utilizada en la granja.The present PhD Thesis consisted of three studies. The first study sought to identify the current gilt acclimation strategies against M. hyopneumoniae performed in European pig farms. To reach that goal, a questionnaire focused on different features of the recipient herd, incoming replacements and acclimation process, was designed. Obtained results indicated that the most common strategy used for M. hyopneumoniae gilt acclimation was vaccination based on multiple doses programs. However, the effect of such process was unknown. In order to know the effect of vaccination against M. hyopneumoniae during the acclimation period in gilts and their piglets, different gilt vaccination schedules were evaluated in the second study of this Thesis. One hundred-eighty gilts were distributed according to the vaccination program into three groups: (A) four doses of a commercial vaccine against M. hyopneumoniae at 2, 4, 6 and 8 weeks post entry (wpe) into acclimation unit, (B) two vaccine doses at 2 and 6, and two doses of phosphate-buffered saline (PBS) at 4 and 8 wpe, and (C) four doses of PBS at the same time points. Vaccinated groups (A and B) showed significantly lower proportion of shedding gilts and higher levels of antibodies compared to the non-vaccinated group after acclimation. However, no significant differences in terms of shedding or levels of antibodies were found between vaccination programs with four or two doses. Sampled piglets at weaning were M. hyopneumoniae negative by real time PCR (rt-PCR) independently of gilt vaccination program administered. In contrast, the proportion of seropositive piglets and levels of antibodies were higher in those coming from vaccinated groups. The present work represents the first attempt to demonstrate that gilt vaccination against M. hyopneumoniae can be an effective tool to reduce the infectious pressure and bacterium variability into replacement batches, as well as provide a long-term humoral immunity to gilts and their offspring. The third study aimed to evaluate the M. hyopneumoniae genetic variability in non-vaccinated and vaccinated pigs showing M. hyopneumoniae-like lung lesions at slaughterhouses, as well as in the vaccines used in each vaccinated farm. To achieve this objective, ten vaccinated and ten non-vaccinated fattening farms positive to M. hyopneumoniae were selected. At slaughterhouse, M. hyopneumoniae-like lung lesions from one batch were scored and three lungs showing the most extensive lesion were collected per batch. Positive samples were genotyped by counting the variable number of tandem repeats of two (P97, P146) or four loci (P97, P146, H1 and H5), and a M. hyopneumoniae typing profile (TP) was assigned. High inter- and limited intra-farm M. hyopneumoniae genetic variability among non-vaccinated and vaccinated fattening farms in Spain using two and four loci. Interestingly, the higher the number of tested loci, the higher the variability. Despite this, only one TP was detected per sample and the TPs detected in pigs from vaccinated farms were different from the strain of the corresponding vaccine used. Furthermore, this study provides novel and interesting data for future discussion regarding the influence of the number of loci tested on the M. hyopneumoniae genetic variability.
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Bourget, Marc A. (Marc Anthony) 1979. "Expanding the wireless communication paradigm." Thesis, Massachusetts Institute of Technology, 2002. http://hdl.handle.net/1721.1/87185.
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Thesis (M.Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2002."June 2002."
Includes bibliographical references (leaves 44-45).
by Marc A. Bourget.
M.Eng.
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Music, Craig 1978. "Expanding the wireless communication paradigm." Thesis, Massachusetts Institute of Technology, 2002. http://hdl.handle.net/1721.1/8077.
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Börjesson, Alexandra, and Mattias Askerson. "Suitability Analysis for Expanding Companies." Thesis, KTH, Geoinformatik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-210892.
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When companies are expanding, they are searching for optimal locations according to parameters which are important for the company. Companies for which the geographic location is important needs to rely on geographic aspects to find the optimal site for their service. The geographic tool of using Suitability Analysis can make the planning of expansions more efficient. Is it possible to give a reliable Suitability Analysis and will it differ between different choices of weighting techniques in the analysis? The focus of the study is on the reliability of Suitability Analysis for expanding companies depending on geographic data. It will, through a study on a start-up company, be checked if the Suitability Analysis is different between two frequently used weighting ideas; Analytic Hierarchy Process and Swing Weight Technique, in this type of analysis. The Suitability Analysis will be done using Geographical Information Systems and the result will be two suitability maps. The study results in two different suitability maps, one for each weighting technique, with differences. The different techniques are dissimilar in their subjectivity of the weighting, which is reflected in the result. Suitability Analysis is useful for companies which expansions are depending on geographic aspect. The key to a reliable and useful suitability analysis is depending on a credible source of data for respectively parameter of interest. It decreases the risk of error sources and gives the result a higher reliability.
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Sharpe, Jeremy Edward. "Expanding the synthesis of distributed memory implementations." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/106006.
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Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2015.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references (page 63).
In this thesis, I expanded the programming model implemented by the Sketch language to supplement its distributed memory parallelism with shared memory parallelism that uses the popular fork-join model. The primary contribution of this thesis is the means by which the code is assured to be free of race conditions. Sketch uses constraint satisfaction analysis to ensure it synthesizes code the functions properly for all inputs, and I demonstrate how assertions can be generated and inserted into the analysis to guarantee freedom from race conditions. This expanded programming model is then evaluated using test cases to ensure correct operation and benchmarks to examine overall performance.
by Jeremy Edward Sharpe.
M. Eng.
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Örnberg, Oscar, and Jonas Nylund. "Incrementally Expanding Environment in Deep Reinforcement Learning." Thesis, KTH, Skolan för teknikvetenskap (SCI), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-230754.
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Tillräckligt snabb konvergens till optimala strategier är ett mål inom maskininlärning och speciellt förstärkande inlärning. Realtidslösningar till komplexa inlärningsproblem behövs för att expandera fältet till nya områden där maskininlärning tidigare varit en omöjlighet. I denna rapport introducerar vi en ny metod för att träna djupa Q-learning agenter i en miljö vars storlek är skalbar, i hopp om att förkorta inlärningstiden. I denna metod börjar agenten i en mycket liten miljö där den snabbt kan utforska olika situationer på en liten skala och lära sig att hantera dem. Miljön expanderar sedan bitvis när agenten har lärt sig miljön till en förbestämd standard. På sådant sätt kommer agenten inte att behövs lära om sig miljön utan kan anpassa sina kunskaper från ett mindre sammanhang till ett större. Jämförelsen mellan den Stegvis Expanderade Miljö (IEE) metoden samt den konventionella metoden att från början ge hela miljön till agenten visade att metoderna hade jämförbar prestanda i vissa fall medan IEE metoden visade sig överlägsen i andra situationer. Speciellt i scenarier med en högre learning rate så förbättrade vår metod sin strategi snabbare. Den vanliga metoden presterade aldrig bättre än IEE metoden. Vi drog slutsatsen att vår föreslagna metod är överlägsen den vanliga metoden, den är robustare i val av parametrar och presterar bättre eller lika bra i alla testade fall.The very long times required to converge to optimal policies is a problem affecting machine learning and reinforcement learning in particular. Real-time solution on complex learning problems are necessary to expand the field into new domains where machine learning has previously been unfeasible. In this paper we introduce a novel method for training deep q-learning agents in an environment where the size can be dynamically scaled, in order to improve learning time. In this framework the agent starts in a very small environment where it can quickly experience different situations in a small scale and learn to handle them properly. As the agent learns the environment enough to reach certain predefined performance goals, the environment is expanded to increase complexity. The agent should then not have to relearn the environment completely, but simply adapt to the larger environment. This Incrementally Expanding Environment (IEE) method was compared to the conventional, deep q-learning method of training the agent on the full environment size from the beginning. Results showed that in some situations the methods performed identically, where in some situations the IEE method performed better. Particularly in scenarios with higher learning rates our framework improved its policy noticeably faster than the conventional method. The conventional method also notably never performed better than the IEE method. We thus conclude that the proposed framework is superior the the conventional one, being more robust to parameter choice and performing as well or better in all observed cases.
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Minervini, Leo Fulvio. "Essays on optimal spectrum management for expanding wireless communications." Thesis, University of Warwick, 2010. http://wrap.warwick.ac.uk/49061/.
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Wireless communications are experiencing an unprecedented expansion. The increasing mobility of the communication society and the pace of technological change are growing pressure for more spectrum to support more users, more uses and more capacity. Thus, spectrum management has become an extremely important part of wireless communications. A few regulators are changing their traditional ‘command and control’ approach. Nevertheless, many features of optimal spectrum management are still widely discussed. This work is aimed at contributing to that discussion. The key insight is that spectrum management can benefit from more liberal spectrum sharing. This work set out to answer three main research questions: (i) whether there is a theoretical framework which can be used to analyze and guide spectrum policy reform, when moving from a traditional ‘command and control’ regime to a market-inspired one; (ii) whether it is possible to design a plausible mechanism which can promote efficient allocation and assignment of spectrum commons; (iii) whether (and how) technological developments could enable band sharing methods outside the traditional management framework and without harmful interference. The literature on transition economics and policy was used to help answer the first research question. Evidence from liberalizing countries was positively analyzed to discuss reforms of spectrum allocation and assignment methods. Most countries have adopted strategies that gradually change their spectrum policies and started by using more liberal methods to assign spectrum. It is also argued that future spectrum reforms might benefit from insights presented in the transition economics literature. A translation of a model on cartel quotas under majority rule is proposed to answer the second research question. The work verifies, firstly, that an analogous set of properties is satisfied under our assumptions and that the median-index theorem applies, mutatis mutandis, to our setting. Thus firms bidding to acquire spectrum commons contribute a minimum amount of their wealth; the sum of contributions offered is then compared to other bids for the same spectrum, which is allocated to the highest bidder. The last research question considers novel ways of spectrum sharing that might be enabled by technological developments. The work explores contributions, from various research areas, regarding management of scarce resources. Those contributions are discussed with respect to shared spectrum access. It is suggested that spectrum management might benefit from methods which enable the management of pooled (intermittent) demands for access, especially methods in line with fair sojourn protocols.
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Wisnewski, Michael Giles. "Impulsive fluidization of bi-disperse mixture in an expanding volume." Thesis, Massachusetts Institute of Technology, 1994. http://hdl.handle.net/1721.1/37711.
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Lagoudas, Georgia Kerasia. "Expanding the limits of Scale and sensitivity in microbial genomics." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/119970.
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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2018.Cataloged from PDF version of thesis.
Includes bibliographical references (pages 118-128).
Sequencing of microbial genomes has enabled new understanding of human health and disease. Certain microbes can support human health through the microbiota, helping to train our immune system or supply essential nutrients. In other cases, microbes may be pathogenic, overwhelming the immune system and causing infection. Low-cost and accessible DNA sequencing has allowed us to learn important information about microbial systems - we can identify what microbes are members of our microbiota and how they change with disease, as well as how pathogenic microbes evolve and acquire resistance to antibiotics. While the cost of sequencing has decreased and allowed for widespread use, studies are now limited by sample acquisition and preparation. In particular, microbial sample preparation has challenges at the limits of sensitivity (low signal to noise ratio) and at the limits of scale (large sample size). In this thesis, I developed methods to address both of these challenges and applied the techniques to study questions in basic biology and in clinical medicine. First, I developed a procedure to sample and sequence the lung microbiome in mouse models, where high background of mammalian DNA in lung samples poses a serious challenge for sequencing preparation. Along with my collaborator, I used this procedure to investigate the microbiome in a murine model of lung cancer. Second, I developed a platform for high-throughput sequencing preparation of bacteria at the scale of thousands of samples, with a 100-fold less cost per sample. I prepared and sequenced 3000 antibiotic-resistance bacteria from a clinical trial studying the role of decolonization procedures. This work provides new insights about microbes in the context of health and disease, and the methods developed here can make samples newly accessible for sequencing at the limits of scale or sensitivity.
MIT Presidential Fellowship MIT Hugh Hampton Young Fellowship NSF Graduate Research Fellowship
by Georgia Kerasia Lagoudas.
Ph. D.
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Gutin, Sarah Anne. "Expanding contraceptive options in South Africa : knowledge, attitudes, and practices surrounding the intrauterine device (IUD)." Master's thesis, University of Cape Town, 2007. http://hdl.handle.net/11427/25805.
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The intrauterine device (IUD) is a safe, effective, convenient, reliable, inexpensive, and cost-effective form of reversible contraception. It rivals female sterilization, injectables, and implants with respect to effectiveness in pregnancy prevention. Once inserted, IUDs are nearly maintenance free; some IUDs can even be used for over a decade. In many settings however, the utilization of this form of contraception is poor and a number of barriers to usage exist. These barriers often relate to lack of knowledge and misperceptions among both potential users and healthcare providers. The IUD is a reliable option that may be an ideal form of contraception for many women in South Africa. In order to make this method available on a wider scale, it is necessary to provide correct information to women and health care professionals and to increase the availability and use of this highly effective method. We conducted a cross-sectional descriptive study designed to assess the current knowledge, attitudes, and practices of potential users and health care providers with respect to the IUD. We recruited 205 women between 15 to 49 years of age who were attending family planning and ST! care services at four primary level public clinics (two in the more urban Western Cape Province and two in the rural Eastern Cape Province in South Africa). In addition, we interviewed 32 providers from 12 clinics (six clinics per province). Ethical approval for this research was obtained from both the University of Cape Town and Walter Sisulu University (formerly the University of the Transkei). Permission was also given by the local and provincial health services. Among clients, knowledge of the IUD was poor. About 26% of women had heard of the IUD. After the method was explained to them, 89.7% of women believed that there were advantages to using the IUD and 72.7% of women said that they would consider using the JUD in the future. Also, women thought the IUD was an easier contraceptive method to use than oral contraceptive pills, injectables, male and female condoms, and female sterilization. Logistic regression modelling showed that, after adjusting for level of education, being from the Western Cape, older age, and having heard of emergency contraception all independently predicted awareness of the IUD method. For the most part, providers knew how the IUD worked to prevent pregnancy; however, providers were lacking in more detailed knowledge about the method and had misinformation about the IUD. Almost all (93 .6%) of providers recognized their need for more information and training about the IUD. Providers reported that barriers to IUD usage in South Africa were lack of knowledge of the method on the part of providers (84.4%), a lack of trained providers to insert or remove the IUD (62.5%), limited availability of the device at health facilities (56.3%), and a lack of knowledge on the part of potential users (46.9%). Despite these barriers, 81 % of providers believed women would be interested in the IUD if they knew about it and 73.3% believed the IUD should be promoted in South Africa. Our results suggest that the IUD would be a welcome addition to the contraceptive method mix in South Africa and that both clients and providers would be interested in this method. It is clear that awareness campaigns among women seeking contraception would be necessary for building support and publicizing the IUD. It will also be necessary to train and educate providers, focusing on up to date information, dispelling myths, and proper insertion and removal techniques. South Africa could re-introduce the IUD into the contraceptive method mix and increase women's choice by adding this valuable, viable, and sustainable option to the contraceptive method mix. The findings of this study, which was requested by the provincial health services, will be used to inform policy and as a starting point for assessing the feasibility and acceptability of a greater role for the IUD in the contraceptive method mix in South Africa.
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Asadollahi, Mohammad Saeid. "Biomechanical Evaluation of Novel Expanding Pedicle Screws Suitable for OsteoporoticLumbar Spine." University of Toledo / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1449711700.
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Johnson, Abayomi Oluwanbe. "Expanding molecular tools for the metabolic engineering of Ralstonia eutropha H16." Thesis, University of Sheffield, 2019. http://etheses.whiterose.ac.uk/22792/.
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Ralstonia eutropha H16 (also known as Cupriavidus necator H16) is a non-pathogenic chemolithoautotrophic soil bacterium. It has increasingly gained biotechnological interest for its use as a microbial cell factory for the production of several valuable bio-based chemicals. However the absence of a large repertoire of molecular tools to engineer this organism remains a critical limiting factor to exploiting its full biotechnological potential. Also, adopting established molecular tools applicable to the more notable microbial hosts such as E. coli and Saccharomyces cerevesiae is severely hampered by chassis-incompatibility and functional variability of essential biological parts. The work detailed in this thesis focuses on the development of key molecular tools crucial to improving the biosynthesis of malonyl-CoA - a precursor metabolite required for the biosynthesis of fatty acids and potentially several valuable bio-products in Ralstonia eutropha H16. All molecular tools developed were based on the broad host range (BHR) plasmid vector backbone of pBBR1MCS1 - a R. eutropha H16-compatible vector. Firstly, to facilitate heterologous pathway optimization, a combination of pre-existing and novel methods of genetic modifications were applied to engineer a collection of 42 promoters. Promoter strengths were characterized using a fluorescence-based assay and benchmarked to the dose-dependent activity of an L-arabinose-inducible PBAD promoter. Next, to detect intracellular accumulation of malonyl-CoA, transcriptional factor-based malonyl-CoA-sensing genetic circuits were developed via careful selection from the promoter collection. Thirdly, BHR L-arabinose-inducible λ-Red plasmid vectors were developed for mediating λ-Red-based genome editing. These were first tested in E. coli BW25113 to confirm their functionality and then subsequently tested in R. eutropha H16. Overall, the collection of engineered promoters yielded a 137-fold range of promoter activity and the malonyl-CoA biosensors responded to changing malonyl-CoA concentrations. The BHR λ-Red plasmids showed high recombination efficiency in E. coli BW25113. The molecular tools developed from this work will further facilitate rapid control and regulation of gene expression in R. eutropha, particularly for malonyl-CoA engineering.
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Loving, James Howard. "Enabling malware remediation in expanding home networks." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/108839.
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Thesis: S.M. in Technology and Policy, Massachusetts Institute of Technology, School of Engineering, Institute for Data, Systems, and Society, Technology and Policy Program, 2017.Thesis: S.M., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2017.
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references (pages 79-91).
As the Internet of Things (IoT) grows, malware will increasingly threaten Internet security and stability. Many actors, from individuals installing antivirus on their personal computers to law enforcement conducting botnet takedowns, have some capability to prevent or remediate malware, but these strategies face technical and economic challenges. These challenges worsen as the IoT expands, due to the high number of IoT devices and other characteristics of the IoT. Fortunately, Internet Service Providers (ISPs) are positioned to effectively contribute to malware remediation efforts, through the detection and notification of compromise. However, Network Address Translation (NAT) and IPv6 Privacy Extensions prevent ISPs from identifying the specific compromised device. We refer to this lastmile extension of the IP traceback problem as the residential source identification problem. As the IoT grows, the problem worsens: IoT devices are less capable of self-remediation and expected to soon outnumber traditional devices, thus imposing a significant cost on customers to triangulate and remediate an infection. To address the residential source identification problem, I propose EDICT, an open-source software package for home routers that will enable consumers to identify a specific device, given retrospective notification of the malicious behavior, without compromising the consumer's privacy. EDICT does this by maintaining a mapping of IP flows to devices through a series of scalable Bloom filters, allowing EDICT to operate under the significant memory constraints of home routers. When a customer is informed of compromise, EDICT will query this connection log using a fuzzy check of the timestamp and source port, both provided by the ISP, iterated across a log of identified devices. EDICT will then provide the customer with user-friendly information on the infection's source, enabling remediation.As the Internet of Things (IoT) grows, malware will increasingly threaten Internet security and stability. Many actors, from individuals installing antivirus on their personal computers to law enforcement conducting botnet takedowns, have some capability to prevent or remediate malware, but these strategies face technical and economic challenges. These challenges worsen as the IoT expands, due to the high number of IoT devices and other characteristics of the IoT. Fortunately, Internet Service Providers (ISPs) are positioned to effectively contribute to malware remediation efforts, through the detection and notification of compromise. However, Network Address Translation (NAT) and IPv6 Privacy Extensions prevent ISPs from identifying the specific compromised device. We refer to this lastmile extension of the IP traceback problem as the residential source identification problem. As the IoT grows, the problem worsens: IoT devices are less capable of self-remediation and expected to soon outnumber traditional devices, thus imposing a significant cost on customers to triangulate and remediate an infection. To address the residential source identification problem, I propose EDICT, an open-source software package for home routers that will enable consumers to identify a specific device, given retrospective notification of the malicious behavior, without compromising the consumer's privacy. EDICT does this by maintaining a mapping of IP flows to devices through a series of scalable Bloom filters, allowing EDICT to operate under the significant memory constraints of home routers. When a customer is informed of compromise, EDICT will query this connection log using a fuzzy check of the timestamp and source port, both provided by the ISP, iterated across a log of identified devices. EDICT will then provide the customer with user-friendly information on the infection's source, enabling remediation.
by James Howard Loving.
S.M. in Technology and Policy
S.M.
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Harrison, Bryant J. "Expanding the capabilities of the ELVIS iLab using component switching." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/46125.
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Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2008.Includes bibliographical references (p. 63).
iLabs are online laboratories that allow users to access, control, and perform real experiments remotely through the Internet. Users are able to access laboratory experiments whenever and wherever they want, bypassing the problem of acquiring expensive equipment and waiting in long queues to use the equipment. iLabs allow students to complement their theoretical calculations and results with real data, providing them with a better understanding of engineering concepts. The ELVIS iLab was developed using the National Instruments Educational Laboratory Virtual Instrumentation Suite, a low cost, all-in-one electronics workstation that can be software controlled. ELVIS iLab is currently in the second version and this thesis explains the modifications made to the first version to add an additional power supply and switching capabilities. These changes increase the quantity, flexibility, and variety of experiments that can be created and provides the possibility of more challenging assignments for students. It also facilitates easier sharing between courses and institutions.
by Bryant J. Harrison.
M.Eng.
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Woodroofe, Carolyn C. 1977. "Molecular engineering strategies for expanding the capabilities of fluorescent zinc (II) sensors." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/28694.
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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2004.Vita.
Includes bibliographical references.
(cont.) affords the two fluorophores, such that excitation of the coumarin at 445 nm and measurement of the emission at 488 nm affords information of the amount of sensor present, while excitation of the fluorescein at 505 nm and measurement of the emission at 535 nm indicates the amount of sensor in the zinc(II)-bound form. This system has been characterized and applied to the study of exogenous zinc(II) fluxes in HeLa cells. Chapter 4: Unimolecular Two-Fluorophore Ratiometric Zn²⁺ Sensing Systems. Dichlorofluorescein compounds covalently bound to zinc(II)-insensitive reporter fluorophores via a rigid cyclohexyl linker have been prepared and characterized. Based on favorable photophysical properties, a Zinpyr-1 species covalently bound to coumarin 343 has been prepared and shown to afford a ratiometric response to excess zinc(II). Chapter 5: ZPI Synthons for Functionalization of Biological Targets. Installation of a functional group prior to Mannich reaction is impractical in many cases. This chapter describes the preparation of reactive ZP1 synthons for direct functionalization of biological targets containing an amine or azide, and reports applications to the synthesis of ZPI conjugates. Appendix 1: Synthetic Approaches to Other Isomerically Pure Functionalizable Fluorophores. Crystallization approaches have been applied to separate fluorescein 5- and 6-sulfonic acid, and subsequent generation of the sulfonyl chlorides is discussed. A dibromofluoran approach to isomerically pure rhodamine carboxylates is based on a similar separation. Basic hydrolysis of the previously described 2',7'-dichlorofluorescein ...
Chapter 1: The Development and Use of Fluorescent Sensors in the Imaging of Physiological Zinc(II): A Review This chapter presents an overview of fluorescent techniques used to image chelatable zinc(II) in vivo. Many intensity-based sensors take advantage of photoinduced electron transfer quenching pathways. Peptide- and protein-based sensors offer excellent selectivity but are poorly suited to intracellular applications. Recently, ratiometric sensors in which the zinc(II) binding event interrupts or alters conjugation within the fluorophore have been described. Chapter 2: Carboxylate-Functionalized Zinpyr-1 Sensors: Synthesis, Characterization, and In Vivo Staining Patterns. A class of Zinpyr-1 sensors containing a carboxylic acid or ester at the 5- or 6-position of the fluorescein has been prepared. These sensors offer decreased background fluorescence and enhanced fluorescence response compared to the parent Zinpyr-1. The acid-functionalized sensors bear a negative charge at physiological pH, rendering them cell-impermeable. The esterified sensors are cell-permeable, but are hydrolyzed in vivo by intracellular esterases, affording a clear delineation of zinc(II)-containing damaged neurons in mechanically-injured or seizure-induced rats, rather than the punctate staining pattern obtained with Zinpyr-1. Chapter 3: Esterase-Dependent Two-Fluorophore Ratiometric Sensing of Zinc(II). This chapter describes a new approach to ratiometric sensing in which a zinc(II)-sensitive fluorescein fluorophore based on Zinpyr-1 is functionalized with a zinc(lI)-insensitive coumarin fluorophore via a flexible ester linker. The flexible linker enables intramolecular quenching of the two fluorophores. Esterase hydrolysis of the linker
by Carolyn C. Woodroofe.
Ph.D.
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Johnson, Brittney E. "Inferring final plans : expanding on a generative and logic-based approach." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/113141.
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Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2017.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references (pages 91-93).
When humans work together to form a plan, they often make mistakes: they misspeak, say things out of order, and negate things they had previously said. We aim to read human team planning conversations and extract the final agreed-upon plan so that a robotic agent may assist in design or execution. Previous work shows that a generative model with logic-based priors is effective when the plan being formed is relatively simple. We present an algorithm that expands on the model by incorporating dialogue acts, which give an indication of how proposed actions are said. We compare our model's performance to humans on the same task. We also validate the model on a toy problem, achieving the desired output 8 times out of 10 (compared to a baseline of 3/10), and run the baseline and our expanded model on a more complex input dialogue. To the best of our knowledge, this is this first work that incorporates dialogue acts into a generative model to perform plan inference.
by Brittney E. Johnson.
M. Eng.
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Liu, Tanya X. "TaleBlazer multiplayer : expanding multiplayer functionality for meaningful location-based AR games." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/91839.
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Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2014.Cataloged from PDF version of thesis.
Includes bibliographical references (page 69).
TaleBlazer is a location-based, augmented reality game platform. Its web-based editor provides game designers with a method to create games regardless of programming experience. Users play these games while walking in the real world, using the mobile application as a gateway for interactions with the virtual world. This thesis extends previous work done on the TaleBlazer multiplayer game platform. It details the implementation of new multiplayer functionalities that allow meaningful interactions between players in multiplayer games
by Tanya X. Liu.
M. Eng.
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Papageorgiou, Athanasios. "Optimization of Unmanned Aerial Vehicles : Expanding the Multidisciplinary Capabilities." Licentiate thesis, Linköpings universitet, Maskinkonstruktion, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-143672.
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Over the last decade, Unmanned Aerial Vehicles (UAVs) have experienced an accelerated growth, and nowadays they are being deployed in a variety of missions that have traditionally been covered by manned aircraft. This unprecedented market expansion has created new and unforeseen challenges for the manufacturing industry which is now called to further reduce the idea-to-market times while simultaneously delivering designs of even higher performance. In this environment of uncertainty and risk, it is without a doubt crucial for the involved actors to find ways to secure their strategic advantage, and hence, implementing the latest design tools has become a critical consideration in every Product Development Process (PDP). To this end, a method that has been frequently applied in the PDP and has shown many successful results in the development of complex engineering products is Multidisciplinary Design Optimization (MDO). In general, MDO can bring additional knowledge regarding the best-suited designs much earlier in the process, and in this respect, it can lead to significant cost and time savings by reducing the total number of refinement iterations. Nevertheless, the organizational and cultural integration of MDO has been often overlooked, while at the same time, several technical aspects of the method for UAV design are still at an elementary level. On the whole, research on MDO is showing a slow progress, and to this date, there are many limitations in both the disciplinary models and the available analysis capabilities. In light of the above, this thesis focuses on the particulars of the MDO methodology, and more specifically, on how it can be best adapted and evolved in order to enhance the development process of UAVs. The primary objective is to study the current trends and gaps of the MDO practices in UAV applications, and subsequently to build upon that and explore how these can be included in a roadmap that will be able to serve a guide for newcomers in the field. Compared to other studies, the problem is herein approached from both a technical as well as organizational perspective, and thus, this research not only aims to propose techniques that can lead to better designs but also solutions that will be meaningful to the PDP. Having established the above foundation, this work shows that the traditional MDO frameworks for UAV design have been neglecting several important features, and it elaborates on how those novel elements can be modeled in order to enable a better integration of MDO into the organizational functions. Overall, this thesis presents quantitative and qualitative data which illustrate the effectiveness of the new framework enhancements in the development process of UAVs, and concludes with discussions on the possible improvement directions towards achieving more and better MDO capabilities.
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Kipling, Kathryn. "Knowledge engineering in bioprocesses." Thesis, University of Newcastle Upon Tyne, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399002.
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González-Tarrío, Carlos. "Expanding the core business : Understanding how to grow in the non-core business." Thesis, KTH, Maskinkonstruktion (Inst.), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-277038.
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Throughout history, large companies have been adapting to the new times. For this, they have had to be able to evolve and change the direction of their offer. In most cases, the offer they have now has nothing to do with what they offered. In other terms, they had to expand their core business. That means changing the main source of incomes. This can be done by moving to another market, creating new products, changing from a product to a service company etc. On the contrary, many companies that led the market have disappeared due to their lack of future vision. After using all its resources in their current core product, they forgot to invest in the future. Once that product became obsolete, the company failed. Looking to the future and deciding which direction to take is not easy. There is no standard successful formula for knowing which direction to take, but there are some common factors that can help reduce the risk. The results from the study show lack of focus and strategy as the main challenges for companies to expand the core. The conclusion is that there is not only one way to expand the core, and each company should adapt their strategies according to the status of the company. In the case of the case company, the strategy is aligned with their status, but the way it is applied should be improved to increase the speed and success rate. Three main recommendations are given to improve the actual expanding-the-core process: Isolate the non-core to increase the focus, better use of their brand position and the competitive advantages it can bring, and to improve the overall knowledge of the company in the non-core products.Genom historien har stora företag anpassat sig till nya tider genom att ändra innehållet i deras erbjudande. I de flesta fall har det erbjudande de nu har ingenting att göra med vad de erbjöd initialt. Med andra ord var de tvungna att utvidga sin kärnverksamhet. Det innebär att bytt huvudinkomstkälla. Detta kan t ex göras genom att hitta en annan marknad, skapa nya produkter, och att gå från ett produkt- till ett serviceföretag. Många företag som tidigare ledde marknaden har försvunnit på grund av sin brist på framtidsvision. Efter att ha använt alla dess resurser i sin nuvarande kärnprodukt, glömde de att investera i framtiden. När produkten blev föråldrad misslyckades företaget. Det är inte enkelt att ta hänsyn till framtiden och bestämma vilken riktning erbjudandet ska ta. Det finns heller ingen standard formel för att veta vilken riktning man ska ta för att bli framgångsrik, men det finns några faktorer som kan bidra till att minska risken. Resultaten från denna studie visar att brist på fokus och strategi är de största utmaningarna för företag att utöka kärnan. Slutsatsen är att det inte bara finns ett sätt att utöka kärnan, och varje företag bör anpassa sina strategier efter företagets situation. Fyra huvudrekommendationer ges för att förbättra den faktiska utvidgningsprocessen
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Emery, Russell N. "Refining and Expanding the Feature Stamping Process." Diss., CLICK HERE for online access, 2005. http://contentdm.lib.byu.edu/ETD/image/etd1004.pdf.
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Johannesson, Emelie. "Video games – A tool for expanding English vocabulary knowledge? : A study of video games potential impact on English vocabulary knowledge in Swedish upper secondary students." Thesis, Karlstads universitet, Institutionen för språk, litteratur och interkultur (from 2013), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-78802.
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This study researches the possibility of video games being a helpful tool when it comes to English vocabulary knowledge, by comparing the English vocabulary knowledge of those that play video games to those that do not play video games. The study also focuses on comparing the English vocabulary knowledge of those that play video games frequently to those that play video games seldomly and discuss why this might make a difference. 37 students were asked to fill in a questionnaire with questions focusing on if they play video games or not, how often they play and what sort of games they played. The second part of the study was a vocabulary test containing 51 words one might encounter whilst playing video games, in this vocabulary test the students were asked to give an English synonym and a Swedish translation of these words. The results of the study revealed that there were differences between the groups, as those that did play video games scored higher on the vocabulary test compared to those that did not play video games. There was also a difference in terms of performance on the vocabulary test depending on how often the students played video games.Denna studie undersöker videospels möjlighet till att vara ett hjälpmedel när det gäller kunskaper i engelskt ordförråd genom att jämföra ordförrådskunskaperna hos de som spelar videospel med de som inte spelar videospel. Studien fokuserar också på att jämföra de engelska ordförrådskunskaperna hos dem som ofta spelar videospel med de som sällan spelar videospel och diskuterar varför detta kan göra en skillnad. 37 elever ombads att fylla i ett frågeformulär med frågor med fokus på om de spelar videospel eller inte, hur ofta de spelar och vilken typ av spel de spelade. Den andra delen av studien var ett ordförrådstest innehållande 51 ord som kan stötas på i videospel, i detta ordförrådstest ombads eleverna att ge en engelsk synonym och en svensk översättning av dessa ord. Resultaten av studien visade att det fanns skillnader mellan grupperna, eftersom de som spelade videospel fick högre poäng på ordförrådstestet jämfört med de som inte spelade videospel. Det fanns också skillnader prestationsmässigt i ordförrådstestet beroende på hur ofta eleverna spelade videospel.
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Kingston, John. "Multi-perspective modelling for knowledge management and knowledge engineering." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/24782.
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The purpose of this thesis is to show how an analytical framework originally intended for information systems architecture can be used to support both knowledge management and knowledge engineering. The framework suggests analysing information or knowledge from six perspectives (Who, What, How, When, Where and Why) at up to six levels of detail (ranging from “scoping” the problem to an implemented solution). The application of this framework to each of CommonKADS’ models is discussed, in the context of several practical applications of the CommonKADS methodology. Strengths and weaknesses in the models that are highlighted by the practical applications are analysed using the framework, with the overall goal of showing where CommonKADS is currently and where it could be usefully extended. The same framework is also applied to knowledge management; it is established that “knowledge management” is in fact a wide collection of different techniques, and the framework appears to be of some use in every case. A specific application of using the framework to resolve common problems in ontology development is presented. The thesis also includes research on mapping knowledge acquisition techniques to CommonKADS’ models (and to the framework); proposing some extensions to CommonKADS’ library of generic inference structures; and it concludes with a suggestion for a “pragmatic” KADS for use on small projects. The aim is to show that this framework both characterises the knowledge required for both knowledge management and knowledge engineering, and to provide a guide to good selection of knowledge management techniques. If the chosen technique should involve knowledge engineering, the wealth of practical advice on CommonKADS in this thesis should also be beneficial.
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Diedrich, Andreas. "Engineering knowledge : how engineers and managers practice knowledge management /." Göteborg : BAS publ, 2004. http://catalogue.bnf.fr/ark:/12148/cb39983743r.
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Mukwambo, Muzwangowenyu. "Exploring and expanding situated cognition in teaching science concepts: the nexus of indigenous knowledge and Western modern science." Thesis, Rhodes University, 2017. http://hdl.handle.net/10962/8382.
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Certain teaching and learning strategies are appropriate in the context of exposing learners to modern science in situated cognition (SC) - the theory that posits that knowing is inseparable from doing - during, for example, visits to industrial operations. The distance and cost of travel, however, excludes most rural teachers and their learners from such SC exposure to Science and technology in industrial settings. To fill this gap between knowledge and practice in the curriculum experience for rural schools, this research investigated the extent to which a SC approach could be used in relation to indigenous knowledge practices (IKP) that have relevance to science teaching for rural science teachers. The study was conducted in three schools in the Zambezi Region of Namibia whereby six science teachers participated in the study. Also, to generate data from the community, the study included Indigenous community members as participants. Only three selected members from the community participated as representatives of the whole community. Essentially, the study explored and expanded possibilities for rural school teachers to use IKP as sites of SC in relation to concepts of pressure in particular and other science concepts. The research thus studied teaching practices as activity systems related to concepts in the school curriculum and the activity system of Indigenous community members. The patterns, regularities and irregularities provided the framing which was used to view SC through the lens of IKP. This framing of SC within the school curriculum was explored using cultural historical activity theory (CHAT) and Engestrom’s expansive learning cycle (ELC). The study was organized into two phases; exploration and the expansive phase. In the exploration phase, interviews, community analysis, document analysis, brainstorming, reflections and audiovisual evidence were used to generate data. The expansive stage used brainstorming, reflections, and interviews, an experimental test, audio-visual evidence, and interviews. Inductive and abductive modes of inference were used to come up with explanations of the research questions. Explanations proceeded using the frameworks of socio-cultural theory and social realism. Some findings from the data generated from the exploration phase revealed that science teachers in the schools studied do not always engage in a SC approach on account of a lack of Western modern science (WMS) resources and factors related to economic marginalization of the learners. Data generated in the same phase revealed that science teachers can engage the SC approach through embracing indigenous knowledge practices (IKP) reflecting Science whereby they can apprentice learners. Some of the other findings from the expansive learning phase show that science teachers in under-resourced schools can engage the SC approach if IK practices are used as mediational tools which can be used as models, icons/symbols, vocabulary, patterns, case studies and practical activities anchored in IKP. From the findings obtained the contribution which the study made was to come up with some methods of infusing indigenous knowledge systems in science teaching. The trend in research related to IK is more aligned to policies rather than how IK can be usefully used for the benefit of science teaching. As the study only looked into the IKP reflecting Science which the participating teachers brainstormed, it provides an insight into how and which other IK practices can be woven into WMS to encourage social transformation accommodative of Afrocentric world views which allows scientific literacy to be achieved.
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Schesser, Derek G. "Mechanics of Expanding Grout Based Grips for Large Scale Composites Testing." Scholarly Repository, 2011. http://scholarlyrepository.miami.edu/oa_theses/298.
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Experimental testing of large composite specimens under tension or shear is inherently challenging because the large required gripping force and resulting local stress concentration tend to break specimens near gripping sites, rather than desired gage sections. A method using expansive grout materials has been proposed since the mid 1990’s. However, there has been no well-established design guideline due to lack of understanding of the gripping pressure developed by the expansive grout material. Key properties including the elastic modulus and linear expansion coefficient are difficult to measure because typical grout materials do not consolidate into coherent solid blocks for traditional property measurement. In this study, the elastic modulus and linear expansion coefficient of an expansive grout material have been indirectly measured through a carefully designed cylindrical system. The expansive grout material is let to expand within thick-walled steel pipes with one end capped and the other end free to the atmosphere. An analytical solution has been derived to correlate the hoop strain on the outer surface of the steel pipe (caused by grout expansion in the pipe) to the grout elastic modulus and linear expansion coefficient. By measuring the exterior surface hoop strains of two different steel pipes, the elastic modulus and linear expansion coefficient have been determined using the analytical solution of thick walled cylinders. With these parameters accurately determined, the interface friction coefficient has been estimated through analyzing actual composite specimen tests. Finally, based on the determined parameters and the analytical solution, an improved design procedure has been proposed.
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Padgen, Michael R. "Expanding Applications of the Nano Intravital Device as a Platform for Exploring Tumor Microenvironments." Thesis, State University of New York at Albany, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3620838.
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The tumor microenvironment has been demonstrated to be a key determinant in the progression of cancer. Unfortunately, the mechanisms behind the different microenvironments (cytokine gradients, hypoxia, hypoglycemia, etc) have not been fully elucidated. Identifying these mechanisms can lead to targeted, individualized therapy to prevent metastasis. The Nano Intravital Device (NANIVID) is a microfabricated, implantable device designed to initiate specific microenvironments in vivo so that the time course of the effects can be observed. With both spatial and temporal control over the induced environments, the affected regions of the tumor can be compared to the rest of the tumor. The NANIVID was first used to establish cytokine gradients to monitor the migration of invasive cancer cells. The three projects that comprise this work expand the applications of the NANIVID to establish the device as a robust platform for investigating tumor microenvironment interactions. The first project released chemical mimics from the device to induce the cellular hypoxic response in tumors to determine how hypoxia affects the fate of disseminated tumor cells. The second project used the NANIVID in combination with an atomic force microscope to investigate the altered mechanics of migrating invasive cancer cells. The final project was to develop a cell counter to monitor the isolation of the invasive subpopulation of cells that were drawn into the device using a chemoattractant. These three projects demonstrate the potential of the NANIVID as a platform for investigating the tumor microenvironment.
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Urwin, Esmond. "Knowledge supported requirement engineering framework." Thesis, University of Nottingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408633.
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Mahmoud, M. A. "Factory building : Design knowledge engineering." Thesis, University of Strathclyde, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382426.
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Dogan, Huseyin. "Managing knowledge for capability engineering." Thesis, Loughborough University, 2013. https://dspace.lboro.ac.uk/2134/14098.
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The enterprises that deliver capability are trying to evolve into through-life businesses by shifting away from the traditional pattern of designing and manufacturing successive generations of products, towards a new paradigm centred on support, sustainability and the incremental enhancements of existing capabilities from technology insertions and changes to process. The provision of seamless through-life customer solutions depends heavily on management of information and knowledge between, and within the different parts of the supply chain enterprise. This research characterised and described Capability Engineering (CE) as applied in the defence enterprise and identified to BAE Systems important considerations for managing knowledge within that context. The terms Capability Engineering and Through Life Capability Management (TLCM), used synonymously in this thesis, denote a complex evolving domain that requires new approaches to better understand the different viewpoints, models and practices. The findings and novelty of this research is demonstrated through the following achievements: • Defined the problem space that Requirements Engineers can use in through-life management projects. • Made a contribution to the development of models for Systems Architects to enable them to incorporate 'soft' systems within their consideration. • Independently developed a TLCM activity model against which BAE Systems validated the BAE Systems TLCM activity model, which is now used by UK Ministry of Defence (MoD). • Developed, and published within INCOSE1, the INCOSE Capability Engineering ontology. • Through the novel analysis of a directly applicable case study, highlighted to Functional Delivery Managers the significance of avoiding the decoupling of information and knowledge in the context of TLCM. • Through experimentation and knowledge gained within this research, identified inadequacies in the TechniCall (rapid access to experts) service which led to the generation of requirements for an improved service which is now being implemented by BAE Systems. The results showed that managing knowledge is distinct when compared to information management. Over-reliance on information management in the absence of tacit knowledge can lead to a loss in the value of the information, which can result in unintended consequences. Capability is realised through a combination of component systems and Capability Engineering is equivalent to a holistic perspective of Systems Engineering. A sector-independent Capability Engineering ontology is developed to enable semantic interoperability between different domains i.e. defence, rail and information technology. This helped to better understand the dependencies of contributing component systems within defence, and supported collaboration across different domains. Although the evaluation of the ontology through expert review has been accomplished; the ontology, KM analysis framework and soft systems transitioning approach developed still need to undergo independent verification and validation. This requires application to other case studies to check and exploit their suitability. This Engineering Doctorate research has been disseminated through a number of peer reviewed publications.
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Elsass, Michael J. "Multipurpose Sharable Engineering Knowledge Repository." The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu991189934.
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Darwish, Ahmed Adel. "Knowledge-based interpretation of satellite images : a knowledge engineering approach." Thesis, University of Nottingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289488.
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Puhl, Aaron A., and University of Lethbridge Faculty of Arts and Science. "Expanding our knowledge of protein tyrosine phosphatase-like phytases : mechanism, substrate specificity and pathways of myo-inositol hexakisphosphate dephosphorylation." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2006, 2006. http://hdl.handle.net/10133/526.
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A novel bacterial protein tyrosine phosphatase (PTP)-like enzyme has recently been isolated that has a PTP-like active site and fold and the ability to dephosphorylate myo-inositol hexakisphosphate. In order to expand our knowledge of this novel class of enzyme, four new representative genes were cloned from 3 different anaerobic bacteria related to clostridia and the recombinant gene products were examined. A combination of site-directed mutagenesis, kinetic, and high-performance ion-pair chromatography studies were used to elucidate the mechanism of hydrolysis, substrate specificity, and pathways of Ins P6 dephosphorylation. The data indicate that these enzymes follow a classical PTP mechanism of hydrolysis and have a general specificity for polyphosphorylated myo-inositol substrates. These enzymes dephosphorylate Ins P6 in a distributive manner, and have the most highly ordered pathways of sequential dephosphorylation of InsP6 characterized to date. Bioinformatic analyses have indicated homologues that are involved in the regulation of cellular function.x, 138 leaves ; 29 cm.
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Roberts, Shantale D. "EXPANDING OUR PRESENT KNOWLEDGE OF THE NON-FICTIONAL WORLD: AN ANALYSIS OF TRANSPORTATION AND IDENTIFICATION WITH VICTIMS AND PERPETRATORS." Cleveland State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1529075576461922.
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Kjellman, Jacob. "Towards omnimaterial printing : Expanding the material palette of acoustophoretic printing." Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-251006.
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Dropp-genereringstekniker är viktiga för industrier som läkemedelsindustrin, livsmedelsindustrin, kosmetikindustrin etc. Traditionella droppgenereringstekniker är dock begränsade i mängden av material som kan processas till droppform. Ett exempel inkjet som är en väletablerad teknik för att generera droppar med hög hastighet (1-10 kHz) och precision (10-20 μm), men kan bara stöta ut vätskor med låga viskositet, ungefär 10-100 gånger viskositeten av vattnet. Akustophoretisk utskrift motiv är att övervinna denna materialbegränsning och har framgångsrikt avkopplat dropputstötning från bläckviskositet. Metoden utnyttjar ickelinjära akustiska krafter för att skriva ut en stor mängd av material med hög kontroll, med viskositet som sträcker sig över fyra storleksordningar (0,5 mPa · s till 25 000 mPa · s). Emellertid är utstötningen baserad på bildandet av en hängande droppe, och i den aktuella prototypen begränsas materialpaletten av akustophoretisk utskrift genom sprider sig över munstycket, vilket begränsar den minsta tillåtnas ytspänningen till ungefär 60 mN / m. I detta arbete införs en munstycksbeläggningsteknik för att expandera mängden av utskrivbara material, med tillåtna ytspänningar så låga som 25 mN / m. Genom att utnyttja generera nanostrukturer med låg ytenergi på munstyckspetsen, tillverkas superavstötande beläggning. Grunden för nanostrukturerna genererades med hjälp av sot från ett paraffin-vaxljus. Ett robust tillverkningsprotokoll har etablerats, och beläggningen fysikaliska egenskaper och prestanda har karaktäriserats. Tre nya tillämpningsområden undersöktes, vilket demonstrerade noviteten hos denna nya metod. Detta arbete banar vägen för en ny uppsättning material som ska behandlas i en droppe-per droppe metodik.Droplet generation techniques are essential for industries such as the pharmaceutical, food industry, cosmetic industry, etc. However, traditional droplet generation techniques are limited in the palette of materials that can processed in a droplet form. For example, inkjet which is a well-established technology to generate droplets of high speed (1-10 kHz) and precision (10-20 μm), but can only eject fluids with low viscosities, roughly 10-100 folds the one of water. Acoustophoretic printing aims to overcome this material limitation and have successfully decoupled droplet ejection from ink viscosity. The method harnesses nonlinear acoustic forces to print a wide range of materials on demand, spanning over four orders of magnitudes (0.5 mPa·sto 25,000 mPa·s). However, the ejection is based on the formation of a pendant drop, and in the current prototype, the material palette of acoustophoretic printing is limited by nozzle wetting, limiting the allowable minimum surface tension to about 60 mN/m. In this work, a nozzle coating technique is introduced in order to expand the material window by processing fluid with a surface tension as low as 25 mN/m. By leveraging self-assembling of nanostructures on the nozzle tip, superamphiphobic coating is successfully manufactured by using a candle soot template.A robust manufacturing protocol has been established, and the coating characterized in its physics and performance.
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Seymour, Kendall Hal. "Joint Analysis of and Applications for Devices with Expanding Motions." BYU ScholarsArchive, 2019. https://scholarsarchive.byu.edu/etd/7725.
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Origami has been extensively studied by engineers for its unique motions and ability to collapse to small volumes. Techniques have been studied for replicating origami-like folding motion in thick materials, but limited practical applications of these techniques have been demonstrated. Developable mechanisms are a new mechanism type that has a similar ability to collapse to a low profile. The cylindrical developable mechanism has the ability to emerge from and conform to a cylindrical surface. In this work, a few practical applications of devices with novel expanding motions are presented. The design and testing of an origami-inspired deployable ballistic barrier, which was designed by combining and modifying existing thickness accommodation techniques, is discussed. The properties of cylindrical developable mechanisms are examined and two devices designed for use with minimally invasive surgical tooling are presented. Various hinge options for small-scale cylindrical developable mechanisms are then reviewed and discussed. A planar modeling assumption for curved lamina emergent torsional joints in thin-walled cylinders is then analytically and empirically validated. Conclusions are drawn and recommendations for future work are given.
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Murgham, Haithem Abualasaad. "Enhancing and Expanding Conventional Simulation Models of Refrigeration Systems for Improved Correlations." University of Dayton / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1544524232130074.
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Loo, Bernard Liat Wen. "Optimization of Recombination Methods and Expanding the Utility of Penicillin G Acylase." Diss., Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/19728.
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Protein engineering can be performed by combinatorial techniques (directed evolution) and data-driven methods using machine-learning algorithms. The main characteristic of directed evolution (DE) is the application of an effective and efficient screen or selection on a diverse mutant library. As it is important to have a diverse mutant library for the success of DE, we compared the performance of DNA-shuffling and recombination PCR on fluorescent proteins using sequence information as well as statistical methods. We found that the diversity of the libraries DNA-shuffling and recombination PCR generates were dependent on type of skew primers used and sensitive to nucleotide identity levels between genes. DNA-shuffling and recombination PCR produced libraries with different crossover tendencies, suggesting that the two protocols could be used in combination to produce better libraries. Data-driven protein engineering uses sequence, structure and function data along with analyzed empirical activity information to guide library design. Boolean Learning Support Vector Machines (BLSVM) to identify interacting residues in fluorescent proteins and the gene templates were modified to preserve interactions post recombination. By site-directed mutagenesis, recombination and expression experiments, we validated that BLSVM can be used to identify interacting residues and increase the fraction of active proteins in the library.
As an extension to the above experiments, DE was applied on monomeric Red Fluorescent Proteins to improve its spectral characteristics and structure-guided protein engineering was performed on penicillin G acylase (PGA), an industrially relevant catalyst, to change its substrate specificity.
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Schreiber, Raphael, and Moisin Monica Bota. "Rebranding “Made in India” through Cultural Sustainability : Exploring and Expanding Indian Perspectives." Thesis, Högskolan i Borås, Akademin för textil, teknik och ekonomi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-25395.
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This exploratory study is a first attempt to translate the Indian cultural context from a socio-cultural, and legal perspective by identifying the values attributed to Indian textile craftsmanship by Indian textile and fashion stakeholders, and how their perspective is influenced by the global recognition and perception of Indian textile crafts and connotation of “Made in India”. At the same time the study investigates the meaning of “sustainability” in the Indian cultural context, in relation to textile craftsmanship, and how this relates to the Western concept of “sustainability”. Through field research in conjunction with a series of in-depth unstructured interviews, this study reveals that Cultural Sustainability is the dominating narrative in the Indian cultural context due to the prevalence of culturally embedded sustainability practices and the role of textile craftsmanship in sustaining livelihood, being a unique exercise of positioning Indian textile craftsmanship within a framework of cultural heritage as a valuable source of knowledge for sustainable practices in the fashion and textile industry. Unique about this study are the India-centric approach combined with the ethnicity of the subjects interviewed - who are, without exception, Indian nationals, whose work, voice and reputation are shaping India's contemporary textile craft -sustainability narrative (being referred to as the “Indian textiles and fashion elite”) and the framing of traditional craftsmanship from a legal perspective, introducing the notion of legal protection of traditional textile knowledge and traditional cultural expressions.
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Lee, You Na. "Expanding understanding of the innovation process: R&D and non-R&D innovation." Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/53903.
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Innovation is widely recognized as a key to economic growth. Most research on the innovation process has focused on the results of R&D projects. The positive relation between R&D intensity as an input and innovative performance as an output has become the canonical image for research on innovation. While R&D is an important input to innovation, there is growing evidence that a significant share of innovation is not born from R&D. Much of this non-R&D innovation consists of incremental improvements to existing products, or process innovations, although non-R&D innovation is not limited to these kinds of improvements. Non-R&D innovations can also come from problem solving activities or pursuit of new product ideas outside of a formal R&D project. Such activities would be missed in innovation accounts based on regular, formal R&D. Given the importance of innovation for the sociology and economics of science, and the central role of innovation in policy debates, this study expands the study of innovation to include non-R&D innovations and analyzes the drivers and outcomes of non-R&D compared to R&D-based innovations, with the goal of improving science and innovation policy by: examining the concept of innovation from different theoretical perspectives (Chapter 2), creating new measures and improving understanding of existing measures (Chapter 3), developing new models of the innovation process based on knowledge and learning that expand beyond the existing emphasis on R&D inputs (Chapter 4), and different participation of R&D and non-R&D innovations in markets for technology (Chapter 5). The main results show that the relative effectiveness of learning by R&D and non-R&D for innovation is contingent on nature of knowledge, characterized by generality (i.e., high mobility/transferability) and visibility (i.e., tighter links between actions and outcomes), and that non-R&D inventions are less likely to engage in the licensing market, but are more likely to have exclusivity clauses than R&D inventions. The study concludes with a discussion of the implications of these findings for management of innovation and innovation policy.
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Rao, Satyajit 1965. "Knowledge repair." Thesis, Massachusetts Institute of Technology, 1991. http://hdl.handle.net/1721.1/13117.
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Quintana-Amate, Santiago. "A new knowledge sourcing framework to support knowledge-based engineering development." Thesis, Cranfield University, 2015. http://dspace.lib.cranfield.ac.uk/handle/1826/10279.
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New trends in Knowledge-Based Engineering (KBE) highlight the need for decoupling the automation aspect from the knowledge management side of KBE. In this direction, some authors argue that KBE is capable of effectively capturing, retaining and reusing engineering knowledge. However, there are some limitations associated with some aspects of KBE that present a barrier to deliver the knowledge sourcing process requested by the industry. To overcome some of these limitations this research proposes a new methodology for efficient knowledge capture and effective management of the complete knowledge life cycle. Current knowledge capture procedures represent one of the main constraints limiting the wide use of KBE in the industry. This is due to the extraction of knowledge from experts in high cost knowledge capture sessions. To reduce the amount of time required from experts to extract relevant knowledge, this research uses Artificial Intelligence (AI) techniques capable of generating new knowledge from company assets. Moreover the research reported here proposes the integration of AI methods and experts increasing as a result the accuracy of the predictions and the reliability of using advanced reasoning tools. The proposed knowledge sourcing framework integrates two features: (i) use of advanced data mining tools and expert knowledge to create new knowledge from raw data, (ii) adoption of a well-established and reliable methodology to systematically capture, transfer and reuse engineering knowledge. The methodology proposed in this research is validated through the development and implementation of two case studies aiming at the optimisation of wing design concepts. The results obtained in both use cases proved the extended KBE capability for fast and effective knowledge sourcing. This evidence was provided by the experts working in the development of each of the case studies through the implementation of structured quantitative and qualitative analyses.
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吳蓬輝 and Fung Fai Ng. "A knowledge analysis model for knowledge engineering in the construction industry." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1990. http://hub.hku.hk/bib/B31232358.
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Ng, Fung Fai. "A knowledge analysis model for knowledge engineering in the construction industry /." [Hong Kong : University of Hong Kong], 1990. http://sunzi.lib.hku.hk/hkuto/record.jsp?B12980286.
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Funkat, Anne-Kathrin. "Prozessbasiertes Knowledge engineering in medizinischen Problemdomänen." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=974935131.
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Makhaba, Thembile. "Knowledge management strategies in engineering organisations." Thesis, Nelson Mandela Metropolitan University, 2015. http://hdl.handle.net/10948/3579.
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Engineering is believed to be one of the oldest professions and it is estimated that engineering existed 10 000 centuries B.C (Before Christ). Engineering plays an important role in making the environment safer, making daily lives more convenient and also contributes to countries’ economic developments. Engineering has advanced in such a way that it is difficult to survive without some kind of engineering these days. The same as engineering, knowledge management also dates back to biblical times just after creation. Knowledge management is not only applied in organisations, but also within communities, societies, and families. Engineering organisations rely the most on past discoveries and product information (knowledge) in order to solve engineering related problems. Due to globalisation of markets and products, shortage of skills and technological advancement, knowledge has become one of the main competitive factors of many organisations. Therefore engineering organisations need to have knowledge management strategies if they are to stay competitive. Different engineering organisations might have similar knowledge management strategies or different knowledge management strategies depending on organisational size, structure and culture and service offered or product offered. Against this background, this study sought to discover what knowledge management strategies are currently implemented in engineering organisations and recommend on strategies that can be implemented and how they can be implemented. The study is based on a review of literature on engineering, engineering organisations, knowledge and knowledge management and a structured questionnaire on knowledge management in engineering organisations. The population for the study was all engineering organisation employees and the engineering organisations in the Eastern Cape Province of South Africa were sampled for the survey.
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May, John Hendy Robert. "Knowledge-based systems in engineering safety." Thesis, University of Bristol, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327937.
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