Journal articles on the topic 'Evofosfamide'
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Harms, Julia K., Tet-Woo Lee, Tao Wang, Amy Lai, Dennis Kee, John M. Chaplin, Nick P. McIvor, et al. "Impact of Tumour Hypoxia on Evofosfamide Sensitivity in Head and Neck Squamous Cell Carcinoma Patient-Derived Xenograft Models." Cells 8, no. 7 (July 13, 2019): 717. http://dx.doi.org/10.3390/cells8070717.
Full textO'Connor, Liam J., Cindy Cazares-Körner, Jaideep Saha, Charles N. G. Evans, Michael R. L. Stratford, Ester M. Hammond, and Stuart J. Conway. "Efficient synthesis of 2-nitroimidazole derivatives and the bioreductive clinical candidate Evofosfamide (TH-302)." Organic Chemistry Frontiers 2, no. 9 (2015): 1026–29. http://dx.doi.org/10.1039/c5qo00211g.
Full textJayaprakash, Priyamvada, Meghan Rice, Krithikaa Rajkumar Bhanu, Brittany Morrow, Joseph Marszalek, Jason Gay, Christopher Vellano, Benjamin Cowen, Dean Welsch, and Michael Curran. "622 Disrupted oxygen supply and tumor hyper- oxygen consumption contribute independently to prostate cancer immune privilege." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (November 2021): A652. http://dx.doi.org/10.1136/jitc-2021-sitc2021.622.
Full textGrande, Enrique, Daniel E. Castellano, Ana B. Custodio, Rocio Garcia-Carbonero, Encarnación González, Carlos López-López, Javier Munarriz, et al. "A phase II trial to assess the activity and safety of the hypoxia-activated prodrug evofosfamide (TH-302) in combination with sunitinib in patients with disseminated grade 1 and 2 pancreatic neuroendocrine tumors (pNET) as a first-line approach: The GETNE-1408 trial." Journal of Clinical Oncology 34, no. 4_suppl (February 1, 2016): TPS479. http://dx.doi.org/10.1200/jco.2016.34.4_suppl.tps479.
Full textBailleul, Quentin, Pauline Navarin, Mélanie Arcicasa, Christine Bal-Mahieu, Angel Montero Carcaboso, Xuefen Le Bourhis, Alessandro Furlan, Samuel Meignan, and Pierre Leblond. "Evofosfamide Is Effective against Pediatric Aggressive Glioma Cell Lines in Hypoxic Conditions and Potentiates the Effect of Cytotoxic Chemotherapy and Ionizing Radiations." Cancers 13, no. 8 (April 9, 2021): 1804. http://dx.doi.org/10.3390/cancers13081804.
Full textLaubach, Jacob P., Noopur Raje, Andrew J. Yee, Philippe Armand, Robert L. Schlossman, Jacalyn Rosenblatt, Michael G. Martin, et al. "Final Results of a Phase 1/2 Open-Label Study to Assess the Safety, Tolerability and Preliminary Efficacy of Evofosfamide, a Hypoxia-Activated Prodrug, and Dexamethasone with or without Bortezomib in Subjects with Relapsed/Refractory Multiple Myeloma." Blood 128, no. 22 (December 2, 2016): 2122. http://dx.doi.org/10.1182/blood.v128.22.2122.2122.
Full textHiggins, Jack P., Nenad Sarapa, Jason Kim, and Eric Poma. "Unexpected pharmacokinetics of evofosfamide observed in phase III MAESTRO study." Journal of Clinical Oncology 36, no. 15_suppl (May 20, 2018): 2568. http://dx.doi.org/10.1200/jco.2018.36.15_suppl.2568.
Full textPourmorteza, Mohsen, Zia U. Rahman, and Mark Young. "Evofosfamide, a new horizon in the treatment of pancreatic cancer." Anti-Cancer Drugs 27, no. 8 (September 2016): 723–25. http://dx.doi.org/10.1097/cad.0000000000000386.
Full textSpiegelberg, Linda, Stefan J. van Hoof, Rianne Biemans, Natasja G. Lieuwes, Damiënne Marcus, Raymon Niemans, Jan Theys, et al. "Evofosfamide sensitizes esophageal carcinomas to radiation without increasing normal tissue toxicity." Radiotherapy and Oncology 141 (December 2019): 247–55. http://dx.doi.org/10.1016/j.radonc.2019.06.034.
Full textAnderson, Robert F., Dan Li, and Francis W. Hunter. "Antagonism in effectiveness of evofosfamide and doxorubicin through intermolecular electron transfer." Free Radical Biology and Medicine 113 (December 2017): 564–70. http://dx.doi.org/10.1016/j.freeradbiomed.2017.10.385.
Full textNytko, Katarzyna J., Ivo Grgic, Sabine Bender, Janosch Ott, Matthias Guckenberger, Oliver Riesterer, and Martin Pruschy. "The hypoxia-activated prodrug evofosfamide in combination with multiple regimens of radiotherapy." Oncotarget 8, no. 14 (February 28, 2017): 23702–12. http://dx.doi.org/10.18632/oncotarget.15784.
Full textDuran, Rafael, Sahar Mirpour, Vasily Pekurovsky, Shanmugasundaram Ganapathy-Kanniappan, Cory F. Brayton, Toby C. Cornish, Boris Gorodetski, et al. "Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer." Clinical Cancer Research 23, no. 2 (July 20, 2016): 536–48. http://dx.doi.org/10.1158/1078-0432.ccr-16-0725.
Full textKumar, Sushil, Jessica D. Sun, Libo Zhang, Reza Bayat Mokhtari, Bing Wu, Fanying Meng, Qian Liu, et al. "Hypoxia-Targeting Drug Evofosfamide (TH-302) Enhances Sunitinib Activity in Neuroblastoma Xenograft Models." Translational Oncology 11, no. 4 (August 2018): 911–19. http://dx.doi.org/10.1016/j.tranon.2018.05.004.
Full textSpiegelberg, L., R. Biemans, N. Lieuwes, R. Niemans, J. Theys, A. Yaromina, F. Verhaegen, P. Lambin, and L. Dubois. "PO-1061: Evofosfamide sensitizes esophageal carcinomas to radiation without increasing normal tissue toxicity." Radiotherapy and Oncology 127 (April 2018): S595. http://dx.doi.org/10.1016/s0167-8140(18)31371-9.
Full textTakakusagi, Yoichi, Shun Kishimoto, Sarwat Naz, Shingo Matsumoto, Keita Saito, Charles P. Hart, James B. Mitchell, and Murali C. Krishna. "Radiotherapy Synergizes with the Hypoxia-Activated Prodrug Evofosfamide: In Vitro and In Vivo Studies." Antioxidants & Redox Signaling 28, no. 2 (January 10, 2018): 131–40. http://dx.doi.org/10.1089/ars.2017.7106.
Full textHong, Cho Rong, Benjamin D. Dickson, Jagdish K. Jaiswal, Frederik B. Pruijn, Francis W. Hunter, Michael P. Hay, Kevin O. Hicks, and William R. Wilson. "Cellular pharmacology of evofosfamide (TH-302): A critical re-evaluation of its bystander effects." Biochemical Pharmacology 156 (October 2018): 265–80. http://dx.doi.org/10.1016/j.bcp.2018.08.027.
Full textBrenner, Andrew, Richard Zuniga, Jessica D. Sun, John Floyd, Charles P. Hart, Stew Kroll, Lisa Fichtel, et al. "Hypoxia-activated evofosfamide for treatment of recurrent bevacizumab-refractory glioblastoma: a phase I surgical study." Neuro-Oncology 20, no. 9 (February 5, 2018): 1231–39. http://dx.doi.org/10.1093/neuonc/noy015.
Full textMcWhirter, Elaine, Omid Hamid, Bartosz Chmielowski, Richard D. Carvajal, David A. Jaffray, Brandon Driscoll, Tina Shek, et al. "A Phase 2 biomarker-enriched study of evofosfamide (TH-302) in patients with advanced melanoma." Journal of Clinical Oncology 33, no. 15_suppl (May 20, 2015): TPS9089. http://dx.doi.org/10.1200/jco.2015.33.15_suppl.tps9089.
Full textBadar, Talha, Damian R. Handisides, Juliana M. Benito, Mary Ann Richie, Gautam Borthakur, Elias Jabbour, Karine Harutyunyan, et al. "Phase I study of evofosfamide, an investigational hypoxia-activated prodrug, in patients with advanced leukemia." American Journal of Hematology 91, no. 8 (June 25, 2016): 800–805. http://dx.doi.org/10.1002/ajh.24415.
Full textJardim-Perassi, Bruna V., Wei Mu, Suning Huang, Michal R. Tomaszewski, Jan Poleszczuk, Mahmoud A. Abdalah, Mikalai M. Budzevich, et al. "Deep-learning and MR images to target hypoxic habitats with evofosfamide in preclinical models of sarcoma." Theranostics 11, no. 11 (2021): 5313–29. http://dx.doi.org/10.7150/thno.56595.
Full textHunter, Francis W., Jules B. L. Devaux, Fanying Meng, Cho Rong Hong, Aziza Khan, Peter Tsai, Troy W. Ketela, et al. "Functional CRISPR and shRNA Screens Identify Involvement of Mitochondrial Electron Transport in the Activation of Evofosfamide." Molecular Pharmacology 95, no. 6 (April 12, 2019): 638–51. http://dx.doi.org/10.1124/mol.118.115196.
Full textLiapis, Vasilios, Irene Zinonos, Agatha Labrinidis, Shelley Hay, Vladimir Ponomarev, Vasilios Panagopoulos, Aneta Zysk, et al. "Anticancer efficacy of the hypoxia‐activated prodrug evofosfamide (TH‐302) in osteolytic breast cancer murine models." Cancer Medicine 5, no. 3 (January 9, 2016): 534–45. http://dx.doi.org/10.1002/cam4.599.
Full textZhang, Libo, Paula Marrano, Bing Wu, Sushil Kumar, Paul Thorner, and Sylvain Baruchel. "Combined Antitumor Therapy with Metronomic Topotecan and Hypoxia-Activated Prodrug, Evofosfamide, in Neuroblastoma and Rhabdomyosarcoma Preclinical Models." Clinical Cancer Research 22, no. 11 (December 30, 2015): 2697–708. http://dx.doi.org/10.1158/1078-0432.ccr-15-1853.
Full textHuang, Yan, Ying Tian, Yuanyuan Zhao, Cong Xue, Jianhua Zhan, Lin Liu, Xiaobo He, and Li Zhang. "Efficacy of the hypoxia-activated prodrug evofosfamide (TH-302) in nasopharyngeal carcinoma in vitro and in vivo." Cancer Communications 38, no. 1 (May 3, 2018): 15. http://dx.doi.org/10.1186/s40880-018-0285-0.
Full textSun, Jessica D., Qian Liu, Dharmendra Ahluwalia, Damien J. Ferraro, Yan Wang, Don Jung, Mark D. Matteucci, and Charles P. Hart. "Comparison of hypoxia-activated prodrug evofosfamide (TH-302) and ifosfamide in preclinical non-small cell lung cancer models." Cancer Biology & Therapy 17, no. 4 (January 28, 2016): 371–80. http://dx.doi.org/10.1080/15384047.2016.1139268.
Full textYounger, Eugenie, Zsuzsanna Papai, Brian Andrew Van Tine, Steven Attia, Karla V. Ballman, Yao Lu, Denise K. Reinke, Patrick Schoffski, William D. Tap, and Robin Lewis Jones. "Subgroup analysis of elderly patients treated within the randomized phase 3 doxorubicin versus doxorubicin plus evofosfamide (SARC021) trial." Journal of Clinical Oncology 36, no. 15_suppl (May 20, 2018): 11575. http://dx.doi.org/10.1200/jco.2018.36.15_suppl.11575.
Full textDomenyuk, Valeriy, Daniel Magee, Zoran Gatalica, Adam Stark, Patrick Kennedy, Anna Barker, Donald A. Berry, et al. "Poly-ligand profiling (PLP) to differentiate pancreatic cancer patients who benefit from gemcitabine+evofosfamide versus gemcitabine+placebo treatment." Journal of Clinical Oncology 36, no. 15_suppl (May 20, 2018): 12067. http://dx.doi.org/10.1200/jco.2018.36.15_suppl.12067.
Full textYoon, J. S., K. H. Lee, G. J. Cheon, Y. J. Bang, and D. Y. Oh. "Phase II study of evofosfamide (TH-302) monotherapy as a second-line treatment in advanced biliary tract cancer." Annals of Oncology 29 (October 2018): viii259. http://dx.doi.org/10.1093/annonc/mdy282.142.
Full textYounger, Eugenie, Karla Ballman, Yao Lu, Zsuzsanna Pápai, Brian A. Van Tine, Steven Attia, Patrick Schöffski, Denise Reinke, William D. Tap, and Robin L. Jones. "Subgroup analysis of older patients treated within the randomized phase 3 doxorubicin versus doxorubicin plus evofosfamide (SARC021) trial." Journal of Geriatric Oncology 11, no. 3 (April 2020): 463–69. http://dx.doi.org/10.1016/j.jgo.2019.05.008.
Full textLiapis, Vasilios, Aneta Zysk, Mark DeNichilo, Irene Zinonos, Shelley Hay, Vasilios Panagopoulos, Alexandra Shoubridge, et al. "Anticancer efficacy of the hypoxia-activated prodrug evofosfamide is enhanced in combination with proapoptotic receptor agonists against osteosarcoma." Cancer Medicine 6, no. 9 (August 10, 2017): 2164–76. http://dx.doi.org/10.1002/cam4.1115.
Full textTran, Nguyen H., Nathan R. Foster, Amit Mahipal, Thomas Byrne, Joleen Hubbard, Alvin Silva, Kabir Mody, Steven Alberts, and Mitesh J. Borad. "Phase IB study of sorafenib and evofosfamide in patients with advanced hepatocellular and renal cell carcinomas (NCCTG N1135, Alliance)." Investigational New Drugs 39, no. 4 (March 1, 2021): 1072–80. http://dx.doi.org/10.1007/s10637-021-01090-w.
Full textLüpfert, Christian, Martin Dyroff, Oliver von Richter, Dieter Gallemann, Samer El Bawab, Hugues Dolgos, Don Jung, Stefan Hecht, and Andreas Johne. "A Novel PBPK Modeling Approach to Assess Cytochrome P450 Mediated Drug-Drug Interaction Potential of the Cytotoxic Prodrug Evofosfamide." CPT: Pharmacometrics & Systems Pharmacology 7, no. 12 (October 31, 2018): 829–37. http://dx.doi.org/10.1002/psp4.12360.
Full textZhang, Shengchi, Li Li, Xianfeng Wei, Xiang Mao, Xueqing Zhang, Yao Liu, Mei Wei, Wei Wang, and Lun Zhang. "Targeting Mesoporous Silica for Synergistic TH-302 and Afatinib Delivery to Nasopharyngeal Carcinoma." Nanoscience and Nanotechnology Letters 12, no. 9 (September 1, 2020): 1127–36. http://dx.doi.org/10.1166/nnl.2020.3211.
Full textXu, Yinyin, Jing Guo, Jing Liu, Ying Xie, Xin Li, Hongmei Jiang, Jingjing Wang, et al. "Hypoxia-induced CREB cooperates MMSET to modify chromatin and promote DKK1 expression in multiple myeloma." Oncogene 40, no. 7 (January 8, 2021): 1231–41. http://dx.doi.org/10.1038/s41388-020-01590-8.
Full textHajj, Carla, James Russell, Charles P. Hart, Karyn A. Goodman, Maeve A. Lowery, Adriana Haimovitz-Friedman, Joseph O. Deasy, and John L. Humm. "A Combination of Radiation and the Hypoxia-Activated Prodrug Evofosfamide (TH-302) is Efficacious against a Human Orthotopic Pancreatic Tumor Model." Translational Oncology 10, no. 5 (October 2017): 760–65. http://dx.doi.org/10.1016/j.tranon.2017.06.010.
Full textDomenyuk, V., X. Liu, D. Magee, Z. Gatalica, A. Stark, P. Kennedy, M. Rosenow, et al. "Poly-Ligand Profiling differentiates pancreatic cancer patients according to treatment benefit from gemcitabine+placebo versus gemcitabine+evofosfamide and identifies candidate targets." Annals of Oncology 29 (June 2018): v36. http://dx.doi.org/10.1093/annonc/mdy151.131.
Full textHegde, Aparna, Priyamvada Jayaprakash, Coline A. Couillault, Sarina Piha-Paul, Daniel Karp, Jordi Rodon, Shubham Pant, et al. "A Phase I Dose-Escalation Study to Evaluate the Safety and Tolerability of Evofosfamide in Combination with Ipilimumab in Advanced Solid Malignancies." Clinical Cancer Research 27, no. 11 (March 26, 2021): 3050–60. http://dx.doi.org/10.1158/1078-0432.ccr-20-4118.
Full textLaubach, Jacob P., Chia-Jen Liu, Noopur S. Raje, Andrew J. Yee, Philippe Armand, Robert L. Schlossman, Jacalyn Rosenblatt, et al. "A Phase I/II Study of Evofosfamide, A Hypoxia-activated Prodrug with or without Bortezomib in Subjects with Relapsed/Refractory Multiple Myeloma." Clinical Cancer Research 25, no. 2 (October 2, 2018): 478–86. http://dx.doi.org/10.1158/1078-0432.ccr-18-1325.
Full textHong, Cho Rong, William R. Wilson, and Kevin O. Hicks. "An Intratumor Pharmacokinetic/Pharmacodynamic Model for the Hypoxia-Activated Prodrug Evofosfamide (TH-302): Monotherapy Activity is Not Dependent on a Bystander Effect." Neoplasia 21, no. 2 (February 2019): 159–71. http://dx.doi.org/10.1016/j.neo.2018.11.009.
Full textLópez-López, Carlos, Teresa Alonso Gordoa, Marta Benavent, Jaume Capdevila, Alex Teule, Ana Custodio, Isabel Sevilla, et al. "Molecular correlation of the activity of evofosfamide (EVO) in combination with sunitinib (SUN) in pancreatic Neuroendocrine Tumors (pNETs) in the SUNEVO GETNE Trial." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): e16706-e16706. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e16706.
Full textGoldman, J., C. Belani, S. Novello, J. von Pawel, T. Csoszi, S. Orlov, S. Kroll, and T. Pearce. "Randomized, Double-Blind, Placebo-Controlled Trial of Evofosfamide (TH-302) in Combination with Pemetrexed in Advanced Non-Squamous Non-Small Cell Lung Cancer." Annals of Oncology 26 (April 2015): i29. http://dx.doi.org/10.1093/annonc/mdv050.46.
Full textBorad, Mitesh J., Eunice Lee Kwak, Andrea Wang-Gillam, Ayman Ibrahim, Julie Aldridge, and Anthony J. Olszanski. "Evofosfamide combined with gemcitabine/nab-paclitaxel in patients with previously untreated locally advanced or metastatic pancreatic adenocarcinoma (PAC): Results of a phase I trial." Journal of Clinical Oncology 34, no. 15_suppl (May 20, 2016): 4114. http://dx.doi.org/10.1200/jco.2016.34.15_suppl.4114.
Full textCsõszi, Tibor, Jonathan Wade Goldman, Maria Szilasi, Joachim Von Pawel, Silvia Novello, Corey Allan Carter, Tudor-Eliade Ciuleanu, et al. "Randomized, double-blind, placebo-controlled trial of evofosfamide (Evo) and pemetrexed (Pem) in advanced non-squamous non-small cell lung cancer (n-s NSCLC)." Journal of Clinical Oncology 34, no. 15_suppl (May 20, 2016): 9075. http://dx.doi.org/10.1200/jco.2016.34.15_suppl.9075.
Full textBorad, M., L. Renfro, N. Foster, P. Martin, S. Alberts, J. Hubbard, A. Silva, T. Halfdanarson, T. Byrne, and C. Erlichman. "P-100 Phase IB study of sorafenib + evofosfamide in patients (pts) with advanced hepatocellular carcinoma (HCC) and renal cell carcinoma (RCC): NCCTG N1153 (Alliance)." Annals of Oncology 27 (June 2016): ii29. http://dx.doi.org/10.1093/annonc/mdw199.95.
Full textHaynes, Jennifer, Trevor D. McKee, Andrew Haller, Yadong Wang, Cherry Leung, Deena M. A. Gendoo, Evelyne Lima-Fernandes, et al. "Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer." Clinical Cancer Research 24, no. 9 (February 23, 2018): 2116–27. http://dx.doi.org/10.1158/1078-0432.ccr-17-1715.
Full textLiu, Arthur, and Michael Curran. "730 Hypoxia reduction in tandem with anti-angiogenic therapy remodels the PDAC microenvironment and potentiates CD40 agonist therapy." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (November 2021): A759. http://dx.doi.org/10.1136/jitc-2021-sitc2021.730.
Full textLeblond, Pierre, Pauline Navarin, Mélanie Arcicasa, Christine Bal-Mahieu, Nicole Lemahieu, Pamela Völkel, Eric Lartigau, Pierre-Olivier Angrand, and Samuel Meignan. "PCM-13THE HYPOXIA-ACTIVATED PRODRUG EVOFOSFAMIDE (TH-302) IS EFFICACIOUS IN PEDIATRIC HIGH GRADE GLIOMA CELL LINES AS A MONOTHERAPY AND IN COMBINATION WITH CHEMOTHERAPIES." Neuro-Oncology 18, suppl 3 (June 2016): iii141.5—iii142. http://dx.doi.org/10.1093/neuonc/now080.13.
Full textTomaszewski, Michal R., Shuxuan Fan, Alberto Garcia, Jin Qi, Youngchul Kim, Robert A. Gatenby, Matthew B. Schabath, et al. "AI-Radiomics Can Improve Inclusion Criteria and Clinical Trial Performance." Tomography 8, no. 1 (February 2, 2022): 341–55. http://dx.doi.org/10.3390/tomography8010028.
Full textSattiraju, Anirudh, Valerie Marallano, Roland Friedel, and Hongyan Zou. "TMIC-59. INVESTIGATING PHYSIOLOGY OF THERAPY RESISTANT, TUMOR-INITIATING GBM CELLS IN HYPOXIC NICHES USING SPATIALLY-SENSITIVE HYPOXIA REPORTER SYSTEM AND SINGLE-CELL RNA SEQUENCING." Neuro-Oncology 21, Supplement_6 (November 2019): vi260—vi261. http://dx.doi.org/10.1093/neuonc/noz175.1093.
Full textHajj, C., J. Russel, A. Haimovitz-Friedman, K. A. Goodman, and J. Humm. "Metabolism of Hypoxia-Activated Prodrug Evofosfamide in Hypoxic and Normoxic Conditions and Its Potential to Enhance the Therapeutic Efficacy of Single-Dose Radiation Therapy in Pancreatic Cancer." International Journal of Radiation Oncology*Biology*Physics 93, no. 3 (November 2015): S184. http://dx.doi.org/10.1016/j.ijrobp.2015.07.440.
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