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Dissertations / Theses on the topic 'Eukaryotic gene'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Kielbasa, Szymon M. "Bioinformatics of eukaryotic gene regulation." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=982693192.

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2

Marciniak, Jennifer Yuko. "Variability in eukaryotic gene expression /." Diss., Connect to a 24 p. preview or request complete full text in PDF formate. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3208639.

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3

Kiełbasa, Szymon M. "Bioinformatics of eukaryotic gene regulation." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2006. http://dx.doi.org/10.18452/15562.

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Die Aufklärung der Mechanismen zur Kontrolle der Genexpression ist eines der wichtigsten Probleme der modernen Molekularbiologie. Detaillierte experimentelle Untersuchungen sind enorm aufwändig aufgrund der komplexen und kombinatorischen Wechselbeziehungen der beteiligten Moleküle. Infolgedessen sind bioinformatische Methoden unverzichtbar. Diese Dissertation stellt drei Methoden vor, die die Vorhersage der regulatorischen Elementen der Gentranskription verbessern. Der erste Ansatz findet Bindungsstellen, die von den Transkriptionsfaktoren erkannt werden. Dieser sucht statistisch übe

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4

Tang, Terry, and University of Lethbridge Faculty of Arts and Science. "Mathematical modeling of eukaryotic gene expression." Thesis, Lethbridge, Alta. : University of Lethbridge, Dept. of Chemistry and Biochemistry, 2010, 2010. http://hdl.handle.net/10133/2567.

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Using the Gillespie algorithm, the export of the mRNA molecules from their transcription site to the nuclear pore complex is simulated. The effect of various structures in the nu- cleus on the efficiency of export is discussed. The results show that having some of the space filled by chromatin near the mRNA synthesis site shortens the transport time. Next, the complete eukaryotic gene expression including transcription, splicing, mRNA export, translation, and mRNA degradation is modeled using delay stochastic simulation. This allows for the study of stochastic effects during the process and on

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5

Benovoy, David. "Ectopic gene conversions in eukaryotic genomes." Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/27111.

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We studied ectopic gene conversions, i.e., gene conversions between duplicated genes located at different chromosomal positions, in eukaryotic genomes. In the first part we examined the factors affecting ectopic gene conversions in the human genome and compared their characteristics to those observed in other eukaryotic and prokaryotic species. In the second part, we examined the effect that ectopic conversions have on the GC-content of the duplicated genes found in yeast and Arabidopsis genomes. Using Stanley Sawyer's method implemented in his GENCONV program, we identified and characterized

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6

Sturm, Richard Alan. "Control mechanisms of higher eukaryotic gene transcription--divergent histone genes /." Title page, contents and abstract only, 1985. http://web4.library.adelaide.edu.au/theses/09PH/09phs936.pdf.

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7

Abril, Ferrando Josep Francesc. "Comparative analysis of eukaryotic gene sequence features." Doctoral thesis, Universitat Pompeu Fabra, 2005. http://hdl.handle.net/10803/7108.

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L'incessant augment del nombre de seqüències genòmiques, juntament amb <br/>l'increment del nombre de tècniques experimentals de les que es disposa, <br/>permetrà obtenir el catàleg complet de les funcions cel.lulars de <br/>diferents organismes, incloent-hi la nostra espècie. Aquest catàleg <br/>definirà els fonaments sobre els que es podrà entendre millor com els <br/>organismes funcionen a nivell molecular. Al mateix temps es tindran més <br/>pistes sobre els canvis que estan associats amb les malalties. Per tant, <br/>la seqüència en brut, tal i com s'obté dels projectes de seqüenciació de

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8

Dickinson, P. "Fibronectin gene expression in higher eukaryotic cells." Thesis, University of Manchester, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378322.

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9

Ouma, Zachary Wilberforce. "Topological Properties of Eukaryotic Gene Regulatory Networks." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1512041623395438.

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10

Clark, Francis. "A computational study of gene structure and splicing in model eukaryote organisms /." St. Lucia, Qld, 2003. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17395.pdf.

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11

Lucas, Paul. "Cationic polypeptides for gene delivery to eukaryotic cells." Thesis, University of Bath, 1995. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307110.

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12

Junetha, Syed Jabarulla. "Chemical Biology Approaches for Regulating Eukaryotic Gene Expression." 京都大学 (Kyoto University), 2015. http://hdl.handle.net/2433/202664.

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13

Haque, Mainul. "Mathematical modelling of eukaryotic stress-response gene networks." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12509/.

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Mathematical modelling of gene regulatory networks is a relatively new area which is playing an important role in theoretical and experimental investigations that seek to open the door to understanding the real mechanisms that take place in living systems. The current thesis concentrates on studying the animal stress-response gene regulatory network by seeking to predict the consequence of environmental hazards caused by chemical mixtures (typical of industrial pollution). Organisms exposed to pollutants display multiple defensive stress responses, which together constitute an interlinked gene

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14

Tufarelli, Cristina. "Activation and silencing of Î± globin expression." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365741.

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15

Batenchuk, Cory. "Transcriptional Dynamics of the Eukaryotic Cell." Thesis, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19722.

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Gene regulatory networks are dynamic and continuously remodelled in response to internal and external stimuli. To understand how these networks alter cellular phenotype in response towards specific challenges, my first project sought to develop a methodology to explore how the strength of genetic interactions changes according to environmental context. Defined as sensitivity-based epistasis, the results obtained using this methodology were compared to those generated under the conventional fitness-based approach. By integrating this information with gene expression profiles and physical intera

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16

Huang, George T. J. "Molecular cloning and characterization of multiple transcripts of the hamster ALG7 gene." Thesis, Boston University, 1992. https://hdl.handle.net/2144/31297.

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Thesis (D.Sc.D.)--Boston University, Henry M. Goldman School of Graduate Dentistry, 1992 (Oral Biology).<br>Includes bibliographical references (leaves 70-84).<br>The ALG7 gene encodes the tunicamycin-sensitive, dolichol-P-dependent Nacetylglucosamine- 1-phosphate transferase, GPT, that catalyzes the synthesis of the first dolichollinked sugar, Dol-PP-GlcNAc, in the N-glycosylation pathway. ALG7 has been evQlutionarily conserved and is essential for growth in all eukaryotes. The ALG7 gene expression in yeast is known to be regulated in part by the 3' untranslated regions (UTR) of the ALG7 mult

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17

Spies, Noah (Noah Walter Benjamin). "Cross-regulation and interaction between eukaryotic gene regulatory processes." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/72637.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2012.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student submitted PDF version of thesis.<br>Includes bibliographical references.<br>Regulation of genes is fundamental to all living processes and can be exerted at many sequential steps. We studied several eukaryotic gene regulatory mechanisms with an emphasis on understanding the interplay between regulatory processes on a genome-wide scale. Gene s

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18

Baribault, Carl. "Meta State Generalized Hidden Markov Model for Eukaryotic Gene Structure Identification." ScholarWorks@UNO, 2009. http://scholarworks.uno.edu/td/1098.

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Using a generalized-clique hidden Markov model (HMM) as the starting point for a eukaryotic gene finder, the objective here is to strengthen the signal information at the transitions between coding and non-coding (c/nc) regions. This is done by enlarging the primitive hidden states associated with individual base labeling (as exon, intron, or junk) to substrings of primitive hidden states or footprint states. Moreover, the allowed footprint transitions are restricted to those that include either one c/nc transition or none at all. (This effectively imposes a minimum length on exons and the oth

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19

Ter-Hovhannisyan, Vardges. "Unsupervised and semi-supervised training methods for eukaryotic gene prediction." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/26645.

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Thesis (Ph.D)--Biology, Georgia Institute of Technology, 2009.<br>Committee Chair: Mark Borodovky; Committee Member: Jung H. Choi; Committee Member: King Jordan; Committee Member: Leonid Bunimovich; Committee Member: Yury Chernoff. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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20

Treutlein, Barbara. "Mechanisms of eukaryotic gene expression on a single molecule level." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-154993.

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21

Allshire, Robin Campbell. "Construction and analysis of vectors based on bovine papilloma virus." Thesis, University of Edinburgh, 1985. http://hdl.handle.net/1842/11176.

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22

Firek, Simon. "The promotion of ribosomal RNA transcription in Xenopus laevis." Thesis, University of Portsmouth, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236392.

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23

Tan, Song. "Protein-DNA interactions of transcription factors reponsible for cell-type specificity in Saccharomyces cerevisiae." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316019.

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24

Wicksteed, Barton. "Use of gene fusions to study the expression of PYK1 in Saccharomyces cerevisiae." Thesis, University of Aberdeen, 1994. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU068131.

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This study examined the role of <I>PYKI </I>coding sequences in the expression of <I>PYK1::lacZ </I>gene fusions in <I>Saccharomyces cerevisiae. </I>Further aims were to examine the effects of the vector system upon the mRNA levels from these gene fusions the effect that these gene fusions have upon the yeast cell in general. Analysis of the <I>PYK1::lacZ </I>gene fusions revealed that <I>PYK1 </I>coding sequences were responsible for elevating mRNA levels. This elevation was not due to a single element within the coding region of the <I>PYK1 </I>gene as had been previously proposed (Purvis <I

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25

Sen, Rwik. "REGULATION OF EUKARYOTIC TRANSCRIPTIONAL ELONGATION AND ASSOCIATED DNA REPAIR." OpenSIUC, 2016. https://opensiuc.lib.siu.edu/dissertations/1205.

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Transcriptional elongation is a crucial step in eukaryotic gene regulation whose mis-regulation leads to cellular pathologies. This makes it quite imperative to aim for a better understanding of the processes regulating transcriptional elongation. An important process promoting the association of RNA Polymerase II (RNAPII) with the coding region of the active gene and hence transcriptional elongation is the monoubiquitination of histone H2B at lysine 123. A complex of an E2 conjugase, Rad6p, and an E3 ligase, Bre1p, is essential for this process. Consistent with the role of histone H2B monoubi

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26

Sparks, Michael Edward. "Computational annotation of eukaryotic gene structures algorithms development and software systems /." [Ames, Iowa : Iowa State University], 2007.

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27

Hoyle, Jacqueline. "Molecular genetic characterisation of eukaryotic members of the AAA gene family." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265050.

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28

Piriyapongsa, Jittima. "Origin and evolution of eukaryotic gene sequences derived from transposable elements." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/24766.

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Thesis (Ph.D.)--Biology, Georgia Institute of Technology, 2008.<br>Committee Chair: Jordan, I. King; Committee Member: Borodovsky, Mark; Committee Member: Bunimovich, Leonid; Committee Member: Choi, Jung; Committee Member: McDonald, John.

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29

To, Tsz-Leung. "Transcriptional bursting in eukaryotic gene regulation : molecular basis and functional consequences." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/62062.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2010.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Transcription of mRNA appears to occur in random, intermittent bursts in a large variety of organisms. The statistics of mRNA expression can be described by two parameters: the frequency at which bursts occur (burst frequency) and the average number of mRNA produced within each burst (burst size). The mean steady-state abundance of mRNA is the product of the burst size and burst frequency. Although the experimental evid

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30

Burns, Paul D. "Gene finding in eukaryotic genomes using external information and machine learning techniques." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/49023.

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Gene finding in eukaryotic genomes is an essential part of a comprehensive approach to modern systems biology. Most methods developed in the past rely on a combination of computational prediction and external information about gene structures from transcript sequences and comparative genomics. In the past, external sequence information consisted of a combination of full-length cDNA and expressed sequence tag (EST) sequences. Much improvement in prediction of genes and gene isoforms is promised by availability of RNA-seq data. However, productive use of RNA-seq for gene prediction has been diff

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31

Ferdoush, Jannatul. "Regulation of nuclear phase of eukaryotic gene expression by ubiquitin-proteasome system." OpenSIUC, 2019. https://opensiuc.lib.siu.edu/dissertations/1751.

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Eukaryotic gene expression is a highly synchronized cellular process whose nuclear phase is comprised of transcription, and mRNA processing and export. Transcription can be further comprised of transcription initiation, and elongation. Regulation of transcription initiation, transcription elongation, and mRNA processing and export are crucial for normal cellular function, since misregulation of these processes are associated with various diseases including cancer. Many factors or proteins are associated with these cellular processes which are modulated by different regulatory processes to main

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32

Tang, Shiyuyun. "Improving algorithms of gene prediction in prokaryotic genomes, metagenomes, and eukaryotic transcriptomes." Diss., Georgia Institute of Technology, 2016. http://hdl.handle.net/1853/54998.

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Next-generation sequencing has generated enormous amount of DNA and RNA sequences that potentially carry volumes of genetic information, e.g. protein-coding genes. The thesis is divided into three main parts describing i) GeneMarkS-2, ii) GeneMarkS-T, and iii) MetaGeneTack. In prokaryotic genomes, ab initio gene finders can predict genes with high accuracy. However, the error rate is not negligible and largely species-specific. Most errors in gene prediction are made in genes located in genomic regions with atypical GC composition, e.g. genes in pathogenicity islands. We describe a new algorit

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33

Zheng, Qun. "Analysis of the Caenorhabditis elegans rpc-1 gene." Diss., Columbia, Mo. : University of Missouri-Columbia, 2005. http://hdl.handle.net/10355/4129.

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Thesis (Ph.D.)--University of Missouri-Columbia, 2005.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file viewed on (January 25, 2007) Vita. Includes bibliographical references.

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34

Crowther, Daniel. "Cloning and characterization of Cpf1P from Schizosaccharomyces pombe." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320634.

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35

Kiri, Arpna. "The isolation and function of the 3'untranslated region of the myosin heavy chain genes of skeletal muscle." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325611.

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36

Lahudkar, Shweta L. "REGULATION OF EUKARYOTIC GENE EXPRESSION BY mRNA CAP BINDING COMPLEX AND CAPPING MACHINERY." OpenSIUC, 2014. https://opensiuc.lib.siu.edu/dissertations/834.

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A characteristic feature of gene expression in eukaryotes is the addition of a 5' terminal 7-methylguanine "cap" to nascent pre-messenger RNA (mRNA) in the nucleus. It is the 5'capping process, which proves vital to creating a mature mRNA. The synthesis of an mRNA followed by its capping is a complex undertaking which requires a set of protein factors. The capped mRNA is then exclusively bound by a cap-binding complex (CBC). CBC shields mRNA from exonucleases as well as regulates downstream post-transcriptional events, translational initiation and nonsense mediated mRNA decay (NMD). Any misreg

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37

Mehraein-Ghomi, Farideh. "Analysis of the assembly of a eukaryotic glucose transporter into the Escherichia coli cytoplasmic membrane." Thesis, University of Sussex, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284076.

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38

Shanks, Jonathan Hugh. "Studies of eukaryotic gene expression with special reference to erythhropoietin in the murine kidney." Thesis, Queen's University Belfast, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261932.

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39

Grose, Elizabeth Clare. "Strategies for control of eukaryotic gene expression by the use of small inhibitory RNAs." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612010.

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40

Waters, Lorna Catherine. "Solution structures of proteins and complexes involved in the regulation of eukaryotic gene expression." Thesis, University of Leicester, 2007. http://hdl.handle.net/2381/29722.

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The initial work focused on the interaction between the general coactivator CBP (SID domain) and members of the p160 family of coactivators (AD1 domain), which is a key step in the activation of transcription by nuclear receptors. The solution structure of the CBP SID / SRC1 AD1 complex described in this thesis shows that the two helical domains are intimately associated, with the first helix in SRC1 AD1 and the first three helices in CBP SID forming a four helix bundle, which is capped by the fourth helix of the AD 1 domain. Comparisons with the structure of the related CBP SID / ACTR AD 1 co

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41

Roth, Robyn Lindsay. "The evaluation of heterologous eukaryotic expression systems for the production of biocatalytic enzymes." Thesis, Stellenbosch : Stellenbosch University, 2008. http://hdl.handle.net/10019.1/21733.

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Thesis (PhD)--Stellenbosch University, 2008.<br>ENGLISH ABSTRACT: Heterologous gene expression is of considerable interest for the production of proteins of therapeutic and industrial importance. As the nature of recombinant proteins has become more complex and as transformation systems have been established in more species, so the variety of hosts available for expression has increased. Every system available has both advantages and disadvantages. The research presented here highlights the advantages of selecting the most appropriate expression system for different recombinant proteins.

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42

Narayanan, Vidhya. "Inverted repeats as a source of eukaryotic genome instability." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/24774.

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Thesis (Ph.D.)--Biology, Georgia Institute of Technology, 2009.<br>Committee Chair: Lobachev, Kirill; Committee Co-Chair: Chernoff, Yury; Committee Member: Crouse, Gray; Committee Member: Goodisman, Michael; Committee Member: Streelman, Todd.

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43

Mundt, Max [Verfasser], and Victor [Akademischer Betreuer] Sourjik. "Synthetic noise control in eukaryotic gene expression and signal transduction / Max Mundt ; Betreuer: Victor Sourjik." Marburg : Philipps-Universität Marburg, 2019. http://d-nb.info/1176106805/34.

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44

Wang, Wei. "Assessing selective processes acting on allele frequencies, genomic organisation, gene expression profiles in eukaryotic genomes." Thesis, University of Bath, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.669032.

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How genomes evolve through time and how they change in response to selective pressures remains a key area of research in genomics and evolutionary biology. Genome organization is now known to play a significant role in the regulation of expression patterns with significant clustering according to various parameters of gene expression having been reported in all major taxa. In this thesis I present a comprehensive analysis of sex-biased gene expression in the primate genome and show that there is a significant degree of similarity in sex-biased gene expression among neighbouring genes. Whether

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45

Yari, Fayezeh. "Expression of recombinant neutralizing anti-HIV-1 antibodies in bacteria and eukaryotic cells /." Stockholm : Karolisnska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-079-4/.

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46

Djumagulov, Muminjon. "Accuracy of gene expression through understanding structural basis of a translation cycle on the eukaryotic ribosomes." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ108.

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Le ribosome est un complexe macromoléculaire impliqué dans la synthèse protéique de toutes les cellules vivantes. L’étape d’élongation de cette synthèse est un processus itératif débutant par la sélection au sein du ribosome d’un ARNt aminoacylé suivie par le transfert du peptide du site P- vers le site A- et de la translocation de l’ARNm et de l’ARNt. Le facteur d’élongation 2 (eEF2), qui catalyse la translocation, est l’un des acteurs majeur de cette étape d’élongation chez les eucaryotes. Cependant le mécanisme par lequel eEF2 induit ce processus est encore aujourd’hui inconnu. Dans cette é

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47

Barber, G. N. "Expression of the Lassa virus nucleocapsid protein gene in prokaryotic and eukaryotic cells and application in diagnostic assay systems." Thesis, Open University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235258.

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48

Tsai, Pei-Fang. "TAF1 regulation of gene expression genome-wide localization and transcription profiling /." Diss., [Riverside, Calif.] : University of California, Riverside, 2010. http://proquest.umi.com/pqdweb?index=0&did=2019822761&SrchMode=2&sid=1&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1273863805&clientId=48051.

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Thesis (Ph. D.)--University of California, Riverside, 2010.<br>Includes abstract. Available via ProQuest Digital Dissertations. Title from first page of PDF file (viewed April 24, 2010). Includes bibliographical references. Also issued in print.

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49

Peters, Dimetrie Leslie. "Evaluation of eukaryotic cultured cells as a model to study extracellular DNA / D.L. Peters." Thesis, North-West University, 2011. http://hdl.handle.net/10394/6929.

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The diagnostic value of extracellular occurring DNA (eoDNA) is limited by our lack of understanding its biological function. eoDNA exists in a number of forms, namely vesicle bound DNA, histone/DNA complexes or nucleosomes and virtosomes. These forms of DNA can also be categorized under the terms circulating DNA, cell free DNA, free DNA and extracellular DNA. The DNA can be released by means of form–specific mechanisms and seem to be governed by cell cycle phases and apoptosis. Active release is supported by evidence of energy dependant release mechanisms and various immunological– and messeng

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50

Guljamow, Arthur. "Characterization of two eukaryotic cytoskeletal proteins horizontally transferred to a cyanobacterium." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16481.

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Das Cyanobakterium Microcystis aeruginosa PCC 7806 enthält zwei Proteine unbekannter Funktion, welche eine hohe Sequenzähnlichkeit mit Bausteinen des eukaryotischen Aktinzytoskeletts haben. Eines dieser Proteine ist Aktin selbst, das andere ist das Aktinbindeprotein Profilin. Die vorliegende Arbeit enthält eine detaillierte Charakterisierung beider Proteine sowie Vergleiche mit ihren eukaryotischen Verwandten. So inhibiert, im Gegensatz zu Eukaryoten, cyanobakterielles Aktin nicht das Enzym DNaseI. Es bildet jedoch Polymere, die hier mit Phalloidin visualisiert wurden. Konfokale Mikroskopie o

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