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Relevant bibliographies by topics / Eukaryotic cell replication

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Academic literature on the topic 'Eukaryotic cell replication'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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Journal articles on the topic "Eukaryotic cell replication"

1

Diffley, John F. X. "Eukaryotic DNA replication." Current Opinion in Cell Biology 6, no. 3 (1994): 368–72. http://dx.doi.org/10.1016/0955-0674(94)90028-0.

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Wang, Thomas A., and Joachim J. Li. "Eukaryotic DNA replication." Current Opinion in Cell Biology 7, no. 3 (1995): 414–20. http://dx.doi.org/10.1016/0955-0674(95)80098-0.

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Zannis-Hadjopoulos, Maria, and Gerald B. Price. "Eukaryotic DNA replication." Journal of Cellular Biochemistry 75, S32 (1999): 1–14. http://dx.doi.org/10.1002/(sici)1097-4644(1999)75:32+<1::aid-jcb2>3.0.co;2-j.

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Laskey, Ronald. "The Croonian Lecture 2001 Hunting the antisocial cancer cell: MCM proteins and their exploitation." Philosophical Transactions of the Royal Society B: Biological Sciences 360, no. 1458 (2005): 1119–32. http://dx.doi.org/10.1098/rstb.2005.1656.

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Replicating large eukaryotic genomes presents the challenge of distinguishing replicated regions of DNA from unreplicated DNA. A heterohexamer of minichromosome maintenance (MCM) proteins is essential for the initiation of DNA replication. MCM proteins are loaded on to unreplicated DNA before replication begins and displaced progressively during replication. Thus, bound MCM proteins license DNA for one, and only one, round of replication and this licence is reissued each time a cell divides. MCM proteins are also the best candidates for the replicative helicases that unwind DNA during replication, but interesting questions arise about how they can perform this role, particularly as they are present on only unreplicated DNA, rather than clustered at replication forks. Although MCM proteins are bound and released cyclically from DNA during the cell cycle, higher eukaryotic cells retain them in the nucleus throughout the cell cycle. In contrast, MCMs are broken down when cells exit the cycle by quiescence or differentiation. We have exploited these observations to develop screening tests for the common carcinomas, starting with an attempt to improve the sensitivity of the smear test for cervical cancer. MCM proteins emerge as exceptionally promising markers for cancer screening and early diagnosis.

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Kelly, Thomas, and A. John Callegari. "Dynamics of DNA replication in a eukaryotic cell." Proceedings of the National Academy of Sciences 116, no. 11 (2019): 4973–82. http://dx.doi.org/10.1073/pnas.1818680116.

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Each genomic locus in a eukaryotic cell has a distinct average time of replication during S phase that depends on the spatial and temporal pattern of replication initiation events. Replication timing can affect genomic integrity because late replication is associated with an increased mutation rate. For most eukaryotes, the features of the genome that specify the location and timing of initiation events are unknown. To investigate these features for the fission yeast, Schizosaccharomyces pombe, we developed an integrative model to analyze large single-molecule and global genomic datasets. The model provides an accurate description of the complex dynamics of S. pombe DNA replication at high resolution. We present evidence that there are many more potential initiation sites in the S. pombe genome than previously identified and that the distribution of these sites is primarily determined by two factors: the sequence preferences of the origin recognition complex (ORC), and the interference of transcription with the assembly or stability of prereplication complexes (pre-RCs). We suggest that in addition to directly interfering with initiation, transcription has driven the evolution of the binding properties of ORC in S. pombe and other eukaryotic species to target pre-RC assembly to regions of the genome that are less likely to be transcribed.

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Bielinsky, A. K., and S. A. Gerbi. "Where it all starts: eukaryotic origins of DNA replication." Journal of Cell Science 114, no. 4 (2001): 643–51. http://dx.doi.org/10.1242/jcs.114.4.643.

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Chromosomal origins of DNA replication in eukaryotic cells not only are crucial for understanding the basic process of DNA duplication but also provide a tool to analyze how cell cycle regulators are linked to the replication machinery. During the past decade much progress has been made in identifying replication origins in eukaryotic genomes. More recently, replication initiation point (RIP) mapping has allowed us to detect start sites for DNA synthesis at the nucleotide level and thus to monitor replication initiation events at the origin very precisely. Beyond giving us the precise positions of start sites, the application of RIP mapping in yeast and human cells has revealed a single, defined start point at which replication initiates, a scenario very reminiscent of transcription initiation. More importantly, studies in yeast have shown that the binding site for the initiator, the origin recognition complex (ORC), lies immediately adjacent to the replication start point, which suggests that ORC directs the initiation machinery to a distinct site. Therefore, in our pursuit of identifying ORC-binding sites in higher eukaryotes, RIP mapping may lead the way.

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Walter, Johannes, and John Newport. "Initiation of Eukaryotic DNA Replication." Molecular Cell 5, no. 4 (2000): 617–27. http://dx.doi.org/10.1016/s1097-2765(00)80241-5.

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Kearsey, Stephen E., Karim Labib, and Domenico Maiorano. "Cell cycle control of eukaryotic DNA replication." Current Opinion in Genetics & Development 6, no. 2 (1996): 208–14. http://dx.doi.org/10.1016/s0959-437x(96)80052-9.

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Blow, J. Julian. "Eukaryotic DNA replication reconstituted outside the cell." BioEssays 8, no. 5 (1988): 149–52. http://dx.doi.org/10.1002/bies.950080505.

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Hubscher, U., and JM Sogo. "The Eukaryotic DNA Replication Fork." Physiology 12, no. 3 (1997): 125–31. http://dx.doi.org/10.1152/physiologyonline.1997.12.3.125.

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Before a cell divides into two identical daughter cells, the entire genome must be replicated faithfully. The mechanistic details of this complex macromolecular process, called DNA replication, have recently been clarified. We focus on the current knowledge at the eukaryotic DNA replication fork at the levels of DNA and chromatin.

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Dissertations / Theses on the topic "Eukaryotic cell replication"

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Kipling, D. G. "Studies on replication origins in Saccharomyces cerevisiae." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253151.

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Rindler, Paul Michael. "Eukaryotic replication, cis-acting elements, and instability of trinucleotide repeats." Oklahoma City : [s.n.], 2009.

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Leon, Ronald P. "Structural and functional analysis of MCM helicases in eukaryotic DNA replication /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Biophysics & Genetics, Program in Molecular Biology) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 90-98). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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Amasino, Audra Leigh. "Keep the ORCs at bay : how eukaryotic cells ensure one round of DNA replication per cell cycle." Thesis, Massachusetts Institute of Technology, 2020. https://hdl.handle.net/1721.1/128988.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2020<br>Cataloged from student-submitted PDF of thesis.<br>Includes bibliographical references.<br>During each cell cycle, eukaryotic cells must faithfully replicate their genome, ensuring exactly one full copy is made. Both under-replicating or over-replicating the genome can have deleterious consequences including cell death, genome instability and cancer. Thus, this process is tightly regulated. The major mechanism to ensure that DNA is replicated once per cell cycle entails the temporal separation of two key replication events: helicase loading and helicase activation. Helicase loading occurs during the G1 phase of the cell cycle. In S. cerevisiae cells, Cyclin-Dependent Kinases (CDKs) prevent helicase loading outside of G1 by phosphorylating three of the four helicase-loading proteins: Mcm2-7, Cdc6, and the Origin Recognition Complex (ORC). Phosphorylation of free Mcm2-7 and Cdc6 leads to their removal from the nucleus (Mcm2-7 by nuclear export and Cdc6 by protein degradation). However, phosphorylated ORC remains in the nucleus bound to origins.<br>ORC phosphorylation intrinsically inhibits the helicase loading reaction. In in vitro reconstituted helicase loading reactions, CDK phosphorylation of ORC is sufficient to completely inhibit helicase loading. However, the precise event(s) during helicase loading that are affected by ORC phosphorylation were not known prior to this study. To identify the steps of helicase loading that are inhibited by ORC phosphorylation, we used single-molecule microscopy to compare the progression of helicase loading with phosphorylated versus unphosphorylated ORC. Successful helicase loading results in two head-to-head Mcm2-7 helicases encircling DNA. We show that ORC phosphorylation prevents loading of both the first and second Mcm2-7 complexes. An initial intermediate in helicase loading containing origin DNA and all four proteins (the OCCM) still forms when ORC is phosphorylated, albeit slower.<br>Focusing on events after OCCM formation, we found that ORC phosphorylation alters Cdt1 dissociation kinetics and inhibits successful Mcm2-7 ring closing. ORC is phosphorylated on both the Orc2 and Orc6 subunits in vivo; we find that in vitro phosphorylation of either single subunit leads to nearly identical effects as phosphorylation of both subunits. My studies suggest a model in which ORC directly controls Mcm2-7 ring closing through physical interactions with both Cdt1 and Mcm2-7 and these interactions, and thus ring closing, are inhibited by ORC phosphorylation.<br>by Audra Leigh Amasino.<br>Ph. D.<br>Ph.D. Massachusetts Institute of Technology, Department of Biology

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Isoz, Isabelle. "Role of yeast DNA polymerase epsilon during DNA replication." Doctoral thesis, Umeå : Umeå University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1932.

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Bermudez, Vladimir Paredes. "Role of transcription factors in eukaryotic DNA replication /." free to MU campus, to others for purchase, 1998. http://wwwlib.umi.com/cr/mo/fullcit?p9924864.

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Madine, Mark. "Control of DNA replication in eukaryotes and the coupling of replication to the cell cycle." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264159.

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Davies, Rhian Jane. "Analysis of the Schizosaccharomyces pombe DNA structure dependent checkpoint gene rad26." Thesis, University of Sussex, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297959.

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Narayanan, Vidhya. "Inverted repeats as a source of eukaryotic genome instability." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/24774.

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Thesis (Ph.D.)--Biology, Georgia Institute of Technology, 2009.<br>Committee Chair: Lobachev, Kirill; Committee Co-Chair: Chernoff, Yury; Committee Member: Crouse, Gray; Committee Member: Goodisman, Michael; Committee Member: Streelman, Todd.

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Stevenson, David. "An investigation of potential multi-enzyme complexes of DNA precursor synthesis and DNA replication in eukaryotic cells." Thesis, University of Aberdeen, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277287.

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1. Efforts to display a 'replitase' complex in two disparate lower eukaryotes, <i>Saccharomyces cerevisiae</i> and <i>Physarum polycephalum</i> whether employing physical or kinetic techniques have yielded no evidence to support its existence at this level of biological complexity. 2. Some indication of potential interaction of the folate-metabolising enzymes, dihydrofolate reductase and thymidylate synthase, were attained from affinity chromatography and non-denaturing gel electrophoresis studies of <i>S. cerevisiae</i> lysates. 3. Experiments on lysates prepared from <i>S. cerevisiae</i> spheroplasts imply a cytoplasmic location for the enzymes NDP kinase, dihydrofolate reductase, thymidylate kinase and thymidylate synthase while DNA polymerase, by virtue of its much reduced activity in such extracts, appears to be non-cytoplasmic. 4. Lysates of S-phase <i>P. polycephalum</i> macroplasmodia and exponentially-growing microplasmodia have different DNA polymerase elution profiles when subjected to Sepharose 6B gel filtration chromatography implying the existence of an S-phase-specific activity. 5. Fractions from the trailing section of the S-phase-specific peak of <i>P. polycephalum</i> DNA polymerase following gel filtration chromatography are capable of utilising [<sup>3</sup>H]dTMP but not [<sup>3</sup>H]TdR as substrate. The substrates of dTMP synthetase (dUMP plus co-factors) are not capable of substituting for dTTP in the DNA polymerase assay in these fractions. 6. Thymidylate synthase does not seem to be physically linked with the DNA polymerase from S-phase BHK-21/C13 cells.

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Books on the topic "Eukaryotic cell replication"

1

A, Bryant J., and Francis D, eds. The eukaryotic cell cycle. Taylor & Francis, 2008.

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The eukaryotic cell cycle. Taylor & Francis, 2008.

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Eukaryotic Cell Cycle: Vol 59 SEB Symposium (Experimental Biology Reviews). Taylor & Francis, 2008.

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Campisi, Judith. Perspectives in Cellular Regulation: Bacteria to Cancer. Wiley-Liss, 1991.

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1921-, Pardee Arthur B., and Campisi Judith, eds. Perspectives on cellular regulation: From bacteria to cancer : essays in honor of Arthur B. Pardee. Wiley-Liss, 1991.

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1941-, Kelly Thomas J., and Stillman Bruce, eds. Eukaryotic DNA replication. Cold Spring Harbor Laboratory, 1988.

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L, DePamphilis Melvin, ed. DNA replication in eukaryotic cells. Cold Spring Harbor Laboratory Press, 1996.

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Julian, Blow J., ed. Eukaryotic DNA replication. IRL Press, 1996.

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Eukaryotic DNA replication: A practical approach. Oxford University Press, 1999.

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S, Cox Lynne, ed. Molecular themes in DNA replication. RSC Publishing, 2009.

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Book chapters on the topic "Eukaryotic cell replication"

1

DePamphilis, M. L., W. C. Burhans, L. T. Vassilev, and Z. S. Guo. "Eukaryotic Origins of DNA Replication." In DNA Replication and the Cell Cycle. Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-77040-1_8.

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Taylor, J. H. "Replication of DNA in Eukaryotic Chromosomes." In Results and Problems in Cell Differentiation. Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-540-47783-9_11.

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Stillman, Bruce, Stephen P. Bell, Anindya Dutta, and York Marahrens. "DNA Replication and the Cell Cycle." In Ciba Foundation Symposium 170 - Regulation of the Eukaryotic Cell Cycle. John Wiley & Sons, Ltd., 2007. http://dx.doi.org/10.1002/9780470514320.ch10.

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Knippers, R., and J. Ruff. "Introductory Remarks. The Initiation of Eukaryotic DNA Replication and Its Control." In DNA Replication and the Cell Cycle. Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-77040-1_1.

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Dasso, Mary, Carl Smythe, Kim Milarski, Sally Kornbluth, and John W. Newport. "DNA Replication and Progression Through the Cell Cycle." In Ciba Foundation Symposium 170 - Regulation of the Eukaryotic Cell Cycle. John Wiley & Sons, Ltd., 2007. http://dx.doi.org/10.1002/9780470514320.ch11.

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Paro, Renato, Ueli Grossniklaus, Raffaella Santoro, and Anton Wutz. "Chromatin Dynamics." In Introduction to Epigenetics. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-68670-3_2.

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AbstractThe nucleus of a eukaryotic cell is a very busy place. Not only during replication of the DNA, but at any time in the cell cycle specific enzymes need access to genetic information to process reactions such as transcription and DNA repair. Yet, the nucleosomal structure of chromatin is primarily inhibitory to these processes and needs to be resolved in a highly orchestrated manner to allow developmental, organismal, and cell type-specific nuclear activities. This chapter explains how nucleosomes organize and structure the genome by interacting with specific DNA sequences. Variants of canonical histones can change the stability of the nucleosomal structure and also provide additional epigenetic layers of information. Chromatin remodeling complexes work locally to alter the regular beads-on-a-string organization and provide access to transcription and other DNA processing factors. Conversely, factors like histone chaperones and highly precise templating and copying mechanisms are required for the reassembly of nucleosomes and reestablishment of the epigenetic landscape after passage of activities processing DNA sequence information. A very intricate molecular machinery ensures a highly dynamic yet heritable chromatin template.

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M. Pike, Colleen, Rebecca R. Noll, and M. Ramona Neunuebel. "Exploitation of Phosphoinositides by the Intracellular Pathogen, Legionella pneumophila." In Pathogenic Bacteria. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.89158.

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Manipulation of host phosphoinositide lipids has emerged as a key survival strategy utilized by pathogenic bacteria to establish and maintain a replication-permissive compartment within eukaryotic host cells. The human pathogen, Legionella pneumophila, infects and proliferates within the lung’s innate immune cells causing severe pneumonia termed Legionnaires’ disease. This pathogen has evolved strategies to manipulate specific host components to construct its intracellular niche termed the Legionella-containing vacuole (LCV). Paramount to LCV biogenesis and maintenance is the spatiotemporal regulation of phosphoinositides, important eukaryotic lipids involved in cell signaling and membrane trafficking. Through a specialized secretion system, L. pneumophila translocates multiple proteins that target phosphoinositides in order to escape endolysosomal degradation. By specifically binding phosphoinositides, these proteins can anchor to the cytosolic surface of the LCV or onto specific host membrane compartments, to ultimately stimulate or inhibit encounters with host organelles. Here, we describe the bacterial proteins involved in binding and/or altering host phosphoinositide dynamics to support intracellular survival of L. pneumophila.

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Bensimon, David, Vincent Croquette, Jean-François Allemand, Xavier Michalet, and Terence Strick. "DNA and RNA Polymerases." In Single-Molecule Studies of Nucleic Acids and Their Proteins. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198530923.003.0007.

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This chapter discusses the application of single-molecule approaches in the study of DNA and RNA polymerases. After an introduction to DNA replication and the structure of DNA polymerases, it reviews experiments on DNA polymerization on stretched ssDNA, moving on to DNA polymerization at a stretched DNA fork (mimicking the replication fork). Next it looks at single-molecule sequencing approaches based on DNA polymerization with sequential incorporation of fluorescently labelled nucleotides, comparing with nanopore sequencing. It outlines the use of fluorescent approaches in the study of replication dynamics in vivo in single cells, then discussing transcription by RNA polymerases, the stages of transcription (open-complex, abortive initiation, transcription elongation, termination), and the general structure of RNA polymerases. It describes single-molecule experiments (using manipulation/fluorescent approaches) of the transcription stages and ends with a discussion of experiments studying the dynamics of transcription in vivo at a single locus in a eukaryotic cell with fluorescent labelling.

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Horner, Patrick, David Mabey, David Taylor-Robinson, and Magnus Unemo. "Chlamydial infections." In Oxford Textbook of Medicine, edited by Christopher P. Conlon. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0149.

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Chlamydiae are pathogenic bacteria that likely evolved from host-independent, Gram-negative ancestors. Chlamydiae depend on a eukaryotic host cell for their replication which takes place in an inclusion inside the host cell, and for their dispersal, cell lysis, or extrusion subsequently occurs. Although the phylum Chlamydiae (order Chlamydiales) was originally thought to only contain one family, the Chlamydiaceae, a total of nine families are now recognized. The genus Chlamydia remains the most widely studied. The species Chlamydia trachomatis was proposed some decades ago on the basis of 16S rRNA and 23S rRNA sequences, to belong to the genus Chlamydia together with C. muridarum and C. suis. This chapter primarily focuses on the species C. trachomatis, which causes disease of ocular trachoma (serovars A–C), oculo-anogenital tract infection (serovars D–K) and lymphogranuloma venereum (serovars L1–L3). However, infections caused by C. pneumoniae and C. psittaci are also discussed.

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Kumar Singh, Amresh, Vivek Gaur, and Ankur Kumar. "Role of Phage Therapy in COVID-19 Infection: Future Prospects." In Bacteriophages [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96788.

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The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan City, China, in 2019. After that, the outbreak has grown into a global pandemic and definite treatment for the disease, termed coronavirus disease 2019 (COVID-19), is currently unavailable. The slow translational progress in the field of research suggests that a large number of studies are urgently required for targeted therapy. In this context, this hypothesis explores the role of bacteriophages on SARS-CoV-2, especially concerning phage therapy (PT). Several studies have confirmed that in addition to their antibacterial abilities, phages also show antiviral properties. It has also been shown that PT is effective for building immunity against viral pathogens by reducing the activation of NF kappa B; additionally, phages produce the antiviral protein phagicin. Phages can also induce antiviral immunity by upregulating expression of defensin 2. Phages may protect eukaryotic cells by competing with viral adsorption and viral penetration of cells, virus mediated cell apoptosis as well as replication. Moreover, by inhibiting activation of NF-κB and ROS production, phages can down regulate excessive inflammatory reactions relevant in clinical course of COVID-19. In this chapter, we hypothesize that the PT may play a therapeutic role in the treatment of COVID-19.

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