Dissertations / Theses on the topic 'ETS fusions'
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Carouge, Élisa. "Récepteur MET et fusions ETS : co-acteurs dans la progression du cancer de la prostate." Electronic Thesis or Diss., Université de Lille (2022-....), 2024. https://pepite-depot.univ-lille.fr/ToutIDP/EDBSL/2024/2024ULILS005.pdf.
Prostate cancer (PCa) has the highest incidence of all male cancers in Europe and the USA. In the advanced stages of the disease, the development of metastases (bone metastases in 80% of cases) leads to a high mortality rate. MET receptor and ETS gene fusions with a hormone-dependent promoter are important actors in the progression of prostate cancer. Among the members of the ETS family of transcription factors, ERG is found in 60% of fusions and ETV1 in 10%. MET is a tyrosine kinase receptor expressed in the advanced stages of the disease, in hormone-resistant tumours and in bone metastases. ERG and ETV1 fusions are found throughout the disease, from initiation to metastatic stages. Interestingly, there are many functional links between MET and ERG/ETV1, suggesting that they belong to the same regulatory pathway. The aim of our study is to understand the individual roles of MET receptor and ETS fusions and their collaboration in PCa progression.To this end, we built hormone-independent CaP cellular models in which MET receptor expression and activity are effective and ERG or ETV1 overexpression has been induced via retroviral infection. These models were used to perform phenotypic tests of proliferation, migration and invasion, comparative transcriptomic analysis (RNAseq) and in vivo tests in humanised mice expressing human HGF. The results we obtained show that the transcription factors ERG and ETV1 induce greater migratory and invasive capacities in vitro and that activation of the receptor signalling pathway amplifies the effects. In vivo, ERG and ETV1 induce larger tumour volumes after subcutaneous injection of the cells, and treatment with a specific MET inhibitor reverses these effects. Finally, a transcriptomic analysis comparing the different models, permits to identify genes differentially expressed according to overexpression of ERG, ETV1 and/or activation of MET pathway, signature target genes potentially involved in tumour progression.The data obtained show, for the first time, a collaboration between MET receptor and ERG/ETV1 factors to induce more aggressive characteristics in PCa models. The project aims to identify the molecular signatures of this cooperation in order to highlight prognostic, diagnostic and targeted therapy tools
Hughes, Katelyn. "Gene fusions in cancer: Classification of fusion events and regulation patterns of fusion pathway neighbors." Digital WPI, 2016. https://digitalcommons.wpi.edu/etd-theses/764.
Zartova, Irina. "Mesonic fusion - pion and eta meson production in light ion nuclear fusion reactions." Doctoral thesis, Stockholms universitet, Fysikum, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-39875.
Bisset, Louise Clair. "Fluorescence of a DNA-binding protein." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320129.
White, David Maurice. "Pedagogical Fusion." VCU Scholars Compass, 2007. http://scholarscompass.vcu.edu/etd/993.
Leclercq, Guillaume. "L'imposition directe des fusions intracommunautaires dans lesquelles une société française à l'IS est impliquée." Poitiers, 2000. http://www.theses.fr/2000POIT3023.
BOUREUX, ANTHONY. "Etude des proprietes oncogeniques des proteines de fusion resultant de translocations chromosomiques impliquant des membres de la famille ets." Paris 11, 1999. http://www.theses.fr/1999PA112063.
Lowden, Mia Rochelle Ahmed Shawn. "Genesis of end-to-end chromosome fusions." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,2227.
Title from electronic title page (viewed Jun. 26, 2009). "... in partial fulfillment of requirements for the degree of Doctor of Philosophy in the Department of Biology." Discipline: Biology; Department/School: Biology.
Pradhan, Pushkar S. "Multiresolution based, multisensor, multispectral image fusion." Diss., Mississippi State : Mississippi State University, 2005. http://library.msstate.edu/etd/show.asp?etd=etd-07082005-140541.
Xu, Jin. "Understanding the molecular determinants of prostate tumorigenesis: androgen receptor's requirement for histone deacetylases and the role of recurrent ETS fusion." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1563274481&sid=5&Fmt=2&clientId=48051&RQT=309&VName=PQD.
Meyer, David Christopher. "Universal deformation rings and fusion." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/1883.
DeBerard, M. Scott. "Predicting Lumbar Fusion Surgery Outcomes From Presurgical Patient Variables: The Utah Lumbar Fusion Outcome Study." DigitalCommons@USU, 1998. https://digitalcommons.usu.edu/etd/6142.
Amri, Mohamed-Hédi. "Fusion ensembliste de donn´ees pour la surveillance des personnes d´ependantes en habitat intelligent." Thesis, Orléans, 2015. http://www.theses.fr/2015ORLE2030/document.
Our research work is a part of the project FUI 14 FEDER Collectivités E-monitor’âge. This project takes place within the framework of Ambient Assisted Living (AAL) which aims to improve the safety and the comfort of elderly people living in smart nursing homes. This work aims to monitor the activities of elderly persons using information from different sensors. The ADL (Activities of Daily Living) are used to evaluate the ability of the person to perform on their own a selection of the activities which are essential for an independent living in the everyday life. Generally, process knowledge and measurements coming from sensors are prone to indeterminable noise. In our work, we suppose that these errors are unknown but bounded. Taking into account this hypothesis, we show how to solve the estimation issue using set-membership computations techniques. Our algorithm, based on set-membership approach, consists of two steps. The prediction step, based on the use of a random walk mobility with minimum assumptions (maximum speed of moving), employs the previous state estimate to provide the prediction zone where the person may be located. The correction step uses the informations coming from the sensors to refine this predicted zone. This step uses a relaxed constraints propagation technique, q-relaxed intersection, to deal with faulty measurements. This proposed method allows us to compute the uncertainty domain for the reconstructed localization of moving targets as dealing with outliers
Nguyen, Long Bao. "Fusions of character tables and schur rings of dihedral groups /." Diss., CLICK HERE for online access, 2008. http://contentdm.lib.byu.edu/ETD/image/etd2443.pdf.
Curfs, Garrit Thomas. "Experiment as rhetoric in the cold fusion controversy." Thesis, This resource online, 1990. http://scholar.lib.vt.edu/theses/available/etd-03142009-040600/.
Abyarjoo, Fatemeh. "Sensor Fusion for Effective Hand Motion Detection." FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/2215.
Litant, Thomas F. "The fusion and integration of virtual sensors." W&M ScholarWorks, 2002. https://scholarworks.wm.edu/etd/1539623397.
Lefebvre, Grégoire. "Sélection et fusion de signatures visuelles parcimonieuses : application à la classification d'images naturelles." Bordeaux 2, 2007. http://www.theses.fr/2007BOR21463.
This thesis is concerned with automatic classification. The objective is to assign an identity to a test image among a set of known category. The underlying approach aim at extracting a specific set of parsimonious visual signatures, then selecting and melting discriminative information, before designing a classification scheme adapted to the context. Many methods have been proposed in order to describe visual content. One of the most effective is based on points of interest extraction and local singularity description. In the thesis, this principle is used to define next local signature and combination, based on self-organizing neural maps. A novel image information support s then proposed, being the activation of a multimodal neural model. The proposed methods focus on specific elements of one image class versus the other categories. It permits robustness to viewpoint changes, illumination variations and partial occlusions. The proposed techniques are evaluated and compared to usual methods using various international databases. These experiments show the effectiveness of the proposed approaches, in particular, in the domains of image classification, face recognition and objectionable content exclusion
Merker, James. "Micro-autoradiographic fusion tomography." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002417.
Rigaud, Emmanuelle. "Le processus de reconfiguration des ressources dans les fusions-acquisitions : le cas des firmes rachetées dont la marque est conservée." Paris 10, 2009. http://www.theses.fr/2009PA100034.
The theory of resource-based view stems from the issue of competitive advantage, which is central to the field of strategy. As a matter of fact, the difficulty to put it into practice remains one of its main limits. This research aims to improve the ways of implementing this theory. Thus, it studies situations favorable to resources reconfiguration: mergers and acquisitions. This study mainly focuses on acquired firms whose brand is maintained. Thanks to mergers, these firms have access to either new or mixed resources. This leads to the central research question: in which way are resources being reconfigured in such situations? Five cases dealing with these situations have been analysed. As regards methodology, case analysis has been combined to a comparative approach. The study focuses on organisational reconfiguration processes (taken as a means to access resources reconfiguration). These processes combine synergy (the acquired firm benefits from more efficient resources) and autonomy (the firm's brand is maintained). Templates gathering the sequential analysis of the processes and organisational structuring, allow for the intra-case as well as for the cross-cases analysis, which relies on the process-type theory introduced by Van de Ven (1992). The thesis pays close attention to the dynamic of complex integration processes. It highlights more particularly the latency stage which follows mergers, a phenomenon which has been little studied so far, and different types of trajectories. This research demonstrates that some trajectories lead to a state balancing autonomy and synergy, while others lead to an oscillation phenomenon, to which there seems to be no end
Cavanaugh, Andrew F. "Bayesian Information Fusion for Precision Indoor Location." Digital WPI, 2011. https://digitalcommons.wpi.edu/etd-theses/157.
Heo, Gyeongyong. "Robust kernel methods in context-dependent fusion." [Gainesville, Fla.] : University of Florida, 2009. http://purl.fcla.edu/fcla/etd/UFE0041144.
Bidgood, Lee, and Doctors and Outlaws. "Celebration of 1970s Country-Rock-Grass Fusion." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/1063.
ABURTO, ANDREA. "Caracterisation magnetique du supra conducteur et2-br dans l'etat mixte, du voisinage de la transition de fusion." Paris 11, 1998. http://www.theses.fr/1998PA112294.
Mahmood, Nozad. "Sparse Ridge Fusion For Linear Regression." Master's thesis, University of Central Florida, 2013. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5986.
M.S.
Masters
Statistics
Sciences
Statistical Computing
Seneker, Stephen S. "Synesthetic sensor fusion via a cross-wired artificial neural network." [Johnson City, Tenn. : East Tennessee State University], 2002. http://etd-submit.etsu.edu/etd/theses/available/etd-0403102-164937/unrestricted/SenekerS041902.pdf.
Sun, Roy. "Pedestrian Detection Based on Data and Decision Fusion Using Stereo Vision and Thermal Imaging." Digital WPI, 2016. https://digitalcommons.wpi.edu/etd-theses/308.
Natarajan, Ramkumar. "Efficient Factor Graph Fusion for Multi-robot Mapping." Digital WPI, 2017. https://digitalcommons.wpi.edu/etd-theses/1201.
Perez, Ramona V. "A Charged Fusion Product Diagnostic for a Spherical Tokamak." FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/2233.
Perry, Nathan C. "Fusion of the Parastrophic Matrix and Weak Cayley Table." BYU ScholarsArchive, 2009. https://scholarsarchive.byu.edu/etd/1792.
Mansourbeigi, Seyed M.-H. "Sheaf Theory as a Foundation for Heterogeneous Data Fusion." DigitalCommons@USU, 2018. https://digitalcommons.usu.edu/etd/7363.
LaCaille, Rick. "Outcomes and Presurgical Correlates of Lumbar Interbody Cage Fusion." DigitalCommons@USU, 2003. https://digitalcommons.usu.edu/etd/6180.
Givens, Matthew. "Multiple IMU Sensor Fusion for SUAS Navigation and Photogrammetry." DigitalCommons@USU, 2019. https://digitalcommons.usu.edu/etd/7617.
Bennett, Selester. "The construction and testing of maize transcriptional fusions in yeast (Saccharomyces cerevisiae)." Thesis, This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-10312009-020253/.
Ganta, Srivatsava Ranjit Acharya Rajgopal Sundaraj. "Fusion-aware privacy andwarehousing for healthcare databases." [University Park, Pa.] : Pennsylvania State University, 2009. http://etda.libraries.psu.edu/theses/approved/WorldWideIndex/ETD-3567/index.html.
Nguyen, Long Pham Bao. "Fusion of Character Tables and Schur Rings of Dihedral Groups." BYU ScholarsArchive, 2008. https://scholarsarchive.byu.edu/etd/1429.
Seneker, Stephen Samuel. "Synesthetic Sensor Fusion via a Cross-Wired Artificial Neural Network." Digital Commons @ East Tennessee State University, 2002. https://dc.etsu.edu/etd/673.
Perry, Nathan. "Fusion of the parastrophic matrix and Weak Cayley Table /." Diss., CLICK HERE for online access, 2009. http://contentdm.lib.byu.edu/ETD/image/etd2962.pdf.
Washington, Nicole Leanne. "Regulation of Membrane Fusion Events During Caenorhabditis elegans Spermatogenesis." Tucson, Arizona : University of Arizona, 2006. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1405%5F1%5Fm.pdf&type=application/pdf.
Yuth, Kenneth. "Characterizing the Phosphorylation State of Tie2 using SH2 Domain Fusion Proteins." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/275.
Dinerstein, Jared. "Learning-Based Fusion for Data Deduplication: A Robust and Automated Solution." DigitalCommons@USU, 2010. https://digitalcommons.usu.edu/etd/787.
Berman, Noah Chase Abramowitz Jonathan S. "Relationship between religiosity and thought action fusion a behavioral paradigm /." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2900.
Title from electronic title page (viewed Jun. 23, 2010). "... in partial fulfillment of the requirements for the degree of Master of Arts in the Department of Psychology Clinical Psychology." Discipline: Psychology; Department/School: Psychology.
Francoforte, Kevin. "PARAMETER ESTIMATION USING SENSOR FUSION AND MODEL UPDATING." Master's thesis, University of Central Florida, 2007. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4154.
M.S.
Department of Civil and Environmental Engineering
Engineering and Computer Science
Civil Engineering MS
Friis, Zachary W. "An investigation of MARFE induced H-L back transitions." Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-09072005-155104/.
Dr. Cassiano de Oliveira, Committee Member ; Dr. John Mandrekas, Committee Member ; Dr. Weston M. Stacey, Committee Chair. Includes bibliographical references.
Coll, Jean-Luc. "Caractérisation de gènes dont l'expression est régulée par le pH extracellulaire chez Escherichia coli K-12 et analyse des éléments intervenant en cis ou en trans dans ce contrôle." Lyon 1, 1992. http://www.theses.fr/1992LYO10013.
Lewis, Jennifer S. "Investigation of Group Leadership in a Fission-Fusion Species, the Bottlenose Dolphin." FIU Digital Commons, 2010. http://digitalcommons.fiu.edu/etd/254.
Strauss, Graham L. "Hybrid Fusion Protein for Inhibition of Multiple Proteases for Chronic Wound Healing." Scholar Commons, 2019. https://scholarcommons.usf.edu/etd/7957.
Lu, Jingting. "E-services based information fusion: a user-level information integration framework." [Gainesville, Fla.]: University of Florida, 2002. http://purl.fcla.edu/fcla/etd/UFE0000566.
Kalluri, Hemanth Reddy. "FUSION OF SPECTRAL REFLECTANCE AND DERIVATIVE INFORMATION FOR ROBUST HYPERSPECTRAL LAND COVER CLASSIFICATION." MSSTATE, 2009. http://sun.library.msstate.edu/ETD-db/theses/available/etd-11062009-124333/.
Prouteau, Gaëlle. "Contribution des produits de fusion de la croûte océanique subductée au magmatisme d'arc : exemples du Sud-Est asiatique et approche expérimentale." Brest, 1999. http://www.theses.fr/1999BRES2046.