Academic literature on the topic 'ETS-40'
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Journal articles on the topic "ETS-40"
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Lemarchandel, V., J. Ghysdael, V. Mignotte, C. Rahuel, and P. H. Roméo. "GATA and Ets cis-acting sequences mediate megakaryocyte-specific expression." Molecular and Cellular Biology 13, no. 1 (January 1993): 668–76. http://dx.doi.org/10.1128/mcb.13.1.668.
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The human glycoprotein IIB (GPIIB) gene is expressed only in megakaryocytes, and its promoter displays cell type specificity. We show that this specificity involved two cis-acting sequences. The first one, located at -55, contains a GATA binding site. Point mutations that abolish protein binding on this site decrease the activity of the GPIIB promoter but do not affect its tissue specificity. The second one, located at -40, contains an Ets consensus sequence, and we show that Ets-1 or Ets-2 protein can interact with this -40 GPIIB sequence. Point mutations that impair Ets binding decrease the activity of the GPIIB promoter to the same extent as do mutations that abolish GATA binding. A GPIIB 40-bp DNA fragment containing the GATA and Ets binding sites can confer activity to a heterologous promoter in megakaryocytic cells. This activity is independent of the GPIIB DNA fragment orientation, and mutations on each binding site result in decreased activity. Using cotransfection assays, we show that c-Ets-1 and human GATA1 can transactive the GPIIB promoter in HeLa cells and can act additively. Northern (RNA) blot analysis indicates that the ets-1 mRNA level is increased during megakaryocyte-induced differentiation of erythrocytic/megakaryocytic cell lines. Gel retardation assays show that the same GATA-Ets association is found in the human GPIIB enhancer and the rat platelet factor 4 promoter, the other two characterized regulatory regions of megakaryocyte-specific genes. These results indicate that GATA and Ets cis-acting sequences are an important determinant of megakaryocytic specific gene expression.
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Lemarchandel, V., J. Ghysdael, V. Mignotte, C. Rahuel, and P. H. Roméo. "GATA and Ets cis-acting sequences mediate megakaryocyte-specific expression." Molecular and Cellular Biology 13, no. 1 (January 1993): 668–76. http://dx.doi.org/10.1128/mcb.13.1.668-676.1993.
Full textAbstract:
The human glycoprotein IIB (GPIIB) gene is expressed only in megakaryocytes, and its promoter displays cell type specificity. We show that this specificity involved two cis-acting sequences. The first one, located at -55, contains a GATA binding site. Point mutations that abolish protein binding on this site decrease the activity of the GPIIB promoter but do not affect its tissue specificity. The second one, located at -40, contains an Ets consensus sequence, and we show that Ets-1 or Ets-2 protein can interact with this -40 GPIIB sequence. Point mutations that impair Ets binding decrease the activity of the GPIIB promoter to the same extent as do mutations that abolish GATA binding. A GPIIB 40-bp DNA fragment containing the GATA and Ets binding sites can confer activity to a heterologous promoter in megakaryocytic cells. This activity is independent of the GPIIB DNA fragment orientation, and mutations on each binding site result in decreased activity. Using cotransfection assays, we show that c-Ets-1 and human GATA1 can transactive the GPIIB promoter in HeLa cells and can act additively. Northern (RNA) blot analysis indicates that the ets-1 mRNA level is increased during megakaryocyte-induced differentiation of erythrocytic/megakaryocytic cell lines. Gel retardation assays show that the same GATA-Ets association is found in the human GPIIB enhancer and the rat platelet factor 4 promoter, the other two characterized regulatory regions of megakaryocyte-specific genes. These results indicate that GATA and Ets cis-acting sequences are an important determinant of megakaryocytic specific gene expression.
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Lutsyuk, Iryna, Yaroslav Vakhula, Iryna Tupis, and Iryna Iliuchok. "Catalytic Action of Nitric Acid on The Hydrolysis of ETS-40 Ethyl Silicate." Chemistry & Chemical Technology 15, no. 4 (November 25, 2021): 475–78. http://dx.doi.org/10.23939/chcht15.04.475.
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The effect of concentrated nitric acid on the hydrolysis rate of ETS-40 ethyl silicate hasbeen studied. The duration and maximum temperature of ethyl silicate hydrolysis at different temperatures of the components have been determined. The formation of silica particles in the xerogel structure is shown. The influence of the ETS-40 hydrolysis on the particles size and concentration has been examined. The structure of the xerogel and the composition of the formed particles have been investigated using scanning electron microscopy (SEM) and energy dispersion analysis (EDX).
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Rushton, Lesley. "Health Impact of Environmental Tobacco Smoke in the Horne." Reviews on Environmental Health 19, no. 3-4 (July 1, 2004): 291–310. http://dx.doi.org/10.1515/reveh-2004-19-3-408.
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Abstract Environmental tobacco smoke (ETS) can be a major constituent of air pollution in indoor environments, including the home. Regulation on smoking in the workplace and public places has made the home the dominant unregulated source of ETS, with important potential impacts on children. Between 40% and 60% of cbildren in the United Kingdom are exposed to ETS in the home. Many experimental and human and studies have investigated the adverse health effects of ETS. Substantial evidence shows that in adults ETS is associated with increased risk of chronic respiratory illness, including lung cancer, nasal cancer, and cardiovascular disease. In children, ETS increases the risk of sudden infant death syndrome, middle ear disease, lower respiratory tract illness, prevalence of wheeze and cough, and exacerbates asthma. Although banning smoking in the home would be the optimal reduction strategy, several barrier and ventilation methods can be effective. Nevertheless, such methods are not always practical or acceptable, particularly when social pressures contribute to a lack of support for ETS control in the home. Smoking cessation interventions have bad limited success. Research is needed to explore the barriers to adopting ETS risk-reducing behaviors.
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Perfume, Guadalupe, Sabrina L. Nabhen, Karla Riquelme Barrera, María G. Otero, Liliana G. Bianciotti, and Marcelo S. Vatta. "Long-term modulation of tyrosine hydroxylase activity and expression by endothelin-1 and -3 in the rat anterior and posterior hypothalamus." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 294, no. 3 (March 2008): R905—R914. http://dx.doi.org/10.1152/ajpregu.00555.2007.
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Brain catecholamines are involved in the regulation of biological functions, including cardiovascular activity. The hypothalamus presents areas with high density of catecholaminergic neurons and the endothelin system. Two hypothalamic regions intimately related with the cardiovascular control are distinguished: the anterior (AHR) and posterior (PHR) hypothalamus, considered to be sympathoinhibitory and sympathoexcitatory regions, respectively. We previously reported that endothelins (ETs) are involved in the short-term tyrosine hydroxylase (TH) regulation in both the AHR and PHR. TH is crucial for catecholaminergic transmission and is tightly regulated by well-characterized mechanisms. In the present study, we sought to establish the effects and underlying mechanisms of ET-1 and ET-3 on TH long-term modulation. Results showed that in the AHR, ETs decreased TH activity through ETB receptor activation coupled to the nitric oxide, phosphoinositide, and CaMK-II pathways. They also reduced total TH level and TH phosphorylated forms (Ser 19 and 40). Conversely, in the PHR, ETs increased TH activity through a G protein-coupled receptor, likely an atypical ET receptor or the ETC receptor, which stimulated the phosphoinositide and adenylyl cyclase pathways, as well as CaMK-II. ETs also increased total TH level and the Ser 19, 31, and 40 phosphorylated sites of the enzyme. These findings support that ETs are involved in the long-term regulation of TH activity, leading to reduced sympathoinhibition in the AHR and increased sympathoexcitation in the PHR. Present and previous studies may partially explain the cardiovascular effects produced by ETs when applied to the brain.
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Lawlor, E. R., J. A. Mathers, T. Bainbridge, D. E. Horsman, A. Kawai, J. H. Healey, A. G. Huvos, J. A. Bridge, M. Ladanyi, and P. H. Sorensen. "Peripheral primitive neuroectodermal tumors in adults: documentation by molecular analysis." Journal of Clinical Oncology 16, no. 3 (March 1998): 1150–57. http://dx.doi.org/10.1200/jco.1998.16.3.1150.
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PURPOSE The Ewing tumor (ET) family of peripheral primitive neuroectodermal tumors (pPNETs) are primitive small round-cell tumors (SRCTs) of the bone and soft tissue that occur predominantly in children and adolescents. However, pPNETs only rarely enter the differential diagnosis of bone and soft tissue SRCTs in adults. Recently, gene fusions between the EWS gene and different members of the ETS transcription factor family have been shown to occur in virtually all pPNETs and thus constitute a pathognomonic marker for this tumor subclass. The aim of the present study was to document EWS/ETS fusion gene expression in suspected pPNETs of adults as objective evidence for the existence of this tumor family in older patients. PATIENTS AND METHODS The three contributing molecular diagnostic laboratories retrospectively compiled a cohort of all SRCT cases in which EWS/ETS gene fusions had been shown by molecular analysis. This cohort was surveyed for cases that occurred in patients aged 40 years or older, which were then analyzed for their clinical and pathologic features. RESULTS Nine patients between 40 and 65 years of age were found to have tumors positive for EWS/ETS gene fusions. Standard histopathologic and clinical features of these cases, other than age, were similar to those of childhood pPNETs. Patients were initiated on appropriate therapy after molecular analysis confirmed the diagnosis of pPNET. CONCLUSION Identification of an EWS/ETS gene fusion is useful in providing objective evidence of the diagnosis of pPNET in patients over the age of 40 years. This diagnosis should be considered in adults who present with bone and soft tissue SRCTs and appropriate biopsy specimens should be collected for molecular analysis at the time of diagnosis.
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Whittam, Thomas S., M. L. Wolfe, and R. A. Wilson. "Genetic relationships amongEscherichia coliisolates causing urinary tract infections in humans and animals." Epidemiology and Infection 102, no. 1 (February 1989): 37–46. http://dx.doi.org/10.1017/s0950268800029666.
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SUMMARYGenetic variation in isolates ofEscherichia coliobtained mostly from urinary tract infections in humans and domesticated animals (dogs and cats) was assessed for 16 enzymes using multilocus enzyme electrophoresis to characterize chromosomal genotypes. A total of 148 isolates comprised 63 distinct electrophoretic types (ETs) and about half of the isolates belonged to one of 9 common ETs. A bootstrap analysis of genetic distance between ETs revealed three significant groups of strains. Variation in allele frequencies among groups accounted for 40% of the total genetic diversity. The majority of the common ETs fell into a major cluster of closely related strains. The recovery of multiple isolates of the same electrophoretic types and serotypes from unassociated hosts suggests that these bacteria represent uropathogenic clones that are widely disseminated in humans and animals
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Fleischman, L. F., L. Holtzclaw, J. T. Russell, G. Mavrothalassitis, and R. J. Fisher. "ets-1 in astrocytes: expression and transmitter-evoked phosphorylation." Molecular and Cellular Biology 15, no. 2 (February 1995): 925–31. http://dx.doi.org/10.1128/mcb.15.2.925.
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The ets-1 protein has been primarily studied as a sequence-specific transcriptional regulator that is predominately expressed in lymphoid cells. In this report, we show that ets-1 is also expressed in astrocytes and astrocytoma cells and is regulated during both signal transduction and differentiation. Both isoforms of ets-1, p51 and p42, were found in astrocytes and astrocytoma cells, but whereas expression of p51 was strong, p42, the alternate splice product previously shown to lack the phosphorylation domain, was difficult to detect and was present at a level 10- to 40-fold lower than that of p51. This differed by roughly an order of magnitude from the ratio generally observable in T cells and thymocytes. In two astrocytoma lines of human origin, CCF and 1321N1, ets-1 phosphorylation was stimulated by bradykinin and carbachol, respectively. Glutamate, norepinephrine, and bradykinin elicited phosphorylation of p51 in cultures of primary rat type 1 astrocytes. ets-1 phosphorylation was dramatically blocked by KT5926, an inhibitor of myosin light-chain kinase, suggesting that this kinase may be involved in phosphorylation of ets-1 in vivo. Investigations of retinoic acid-induced differentiation in P19 cells provided further support for a strong correlation of ets-1 with the pathway for astrocyte differentiation.
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Protano, Carmela, Vittoria Cammalleri, Arianna Antonucci, Alexandra Sabina Ungureanu, Francesa Santilli, Stefano Martellucci, Vincenzo Mattei, and Matteo Vitali. "Further Insights on Predictors of Environmental Tobacco Smoke Exposure during the Pediatric Age." International Journal of Environmental Research and Public Health 16, no. 21 (October 23, 2019): 4062. http://dx.doi.org/10.3390/ijerph16214062.
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Background: The smoking ban in public places has reduced Environmental Tobacco Smoke (ETS) exposure for non-smokers, but despite this, domestic environments still remain places at high risk of exposure, and, today, about 40% of children worldwide are exposed to ETS at home. The aims of the study are to investigate the contribution of several factors on ETS exposure among a group of Italian children and to evaluate the changes in smoking precautions adopted at home when the smoker is the mother, the father, or both parents, respectively. Methods: A cross-sectional study was performed on a sample of 519 Italian schoolchildren. Information was collected via a questionnaire. Results: 41.4% of the participants lived with at least one smoker. Almost half of the children exposed to ETS lived with one or more smokers who do not observe any home smoking ban. Lower maternal or paternal educational levels significantly increase the risk of ETS exposure at home and the “worst case” is represented by both parents who smoke. Conclusions: More effective preventive interventions are needed to protect children from ETS exposure. Some interventions should be specifically dedicated to smokers with a low educational level and to mothers that smoke.
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Lapinskas, Erika J., Suzanne Svobodova, Ian D. Davis, Jonathan Cebon, Paul J. Hertzog, and Melanie A. Pritchard. "The Ets Transcription Factor ELF5 Functions as a Tumor Suppressor in the Kidney." Twin Research and Human Genetics 14, no. 4 (August 1, 2011): 316–22. http://dx.doi.org/10.1375/twin.14.4.316.
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Renal cell carcinoma is an important clinical disease with poorly understood etiology. ELF5 is an epithelial-specific member of the Ets family of transcription factors, characterized by the 80 amino acid Ets domain that binds the purine-rich GGAA/T Ets motif found in the promoter regions of a variety of genes. Since ELF5 is highly expressed in kidney and has been postulated to function as a tumor suppressor, at least in the context of the breast, we investigated its role in kidney cancer. In renal cell carcinoma ELF5 expression was consistently decreased in tumor samples versus normal. ELF5 mRNA was decreased in 94% of lesions tested and ELF5 protein was undetectable in 40/40 kidney-derived carcinomas. Re-expression of the ELF5 gene in 786-O renal carcinoma cells suppressed their tumorigenic capacity in vitro and in vivo. This work is the first to suggest that ELF5 has tumor suppressor activity in the kidney.
Dissertations / Theses on the topic "ETS-40"
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Повшук, Василь Володимирович. "Нанозміцнені периклазовуглецеві вогнетриви для футерівки конвертерів з використанням комплексного антиоксиданту." Thesis, НТУ "ХПІ", 2018. http://repository.kpi.kharkov.ua/handle/KhPI-Press/37726.
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Дисертація на здобуття наукового ступеня кандидата технічних наук (доктора філософії) за спеціальністю 05.17.11 – технологія тугоплавких неметалічних матеріалів (161 – Хімічні технології та інженерія). – Національний технічний університет "Харківський політехнічний інститут", Харків, 2018.
Дисертація присвячена розробці складів та основних технологічних параметрів отримання нанозміцнених периклазовуглецевих вогнетривів для різних зон футерівки конвертера з заданими показниками фізико-механічних властивостей і підвищеною стійкістю до дії шлаку та до окиснення. У роботі теоретично обґрунтовано і експериментально доведено можливість одержання нанозміцнених периклазовуглецевих вогнетривів шляхом синтезу наповненої наночастинами β-SiC та NiO вуглецевої матриці-основи заданої структури периклазовуглецевих вогнетривів і забезпечення її максимальної струк-турної міцності за рахунок використання оптимальних співвідношень золь-гель добавок, що модифікують фенолформальдегідну смолу, і компонентів прекурсорів нікелевого антиоксиданту. Визначено технологічні параметри одержання периклазовуглецевих вогнетривів із заданими фізико-механічними властивостями на засаді плавленого периклазу і різною кількістю графіту, шляхом використанням ЕТС-40 або його золю та солей нікелю для створення комплексного антиоксиданту Аl + SiC + Ni(NiO), що забезпечує підвищену стійкість до окиснення за рахунок утворення щільного шару із наночастин β-SiC та Ni(NiO) навколо часток графіту, розроблено безвипалювану технологію та склади магнезіального флюсу для плавки сталі в конвертері з відходів периклазовуглецевих вогнетривів футеровок конвертерів, які сприяють прискоренню наведення шлаку в конвертері та підвищенню стійкості футерівки конвертера.Thesis for the degree of candidate of technical sciences (Ph.D.) in specialty 05.17.11 – technology of refractory nonmetallic materials (161 – chemical technologies and engineering). – National Technical University "Kharkov Polytechnic Institute", Kharkov, 2018. The thesis is devoted to the development of compositions and basic techno-logical parameters for the preparation of nano-reinforced periclase-carbon refractories for various zones of converter lining with prescribed parameters of physical and mechanical properties and increased resistance to slag and oxidation. The possibility of obtaining nano-reinforced periclase-carbon refractories by synthesis of the carbon-matrix matrix of a given structure of periclase-carbon refractories filled with nanoparticles β-SiC and NiO and ensuring its maximum structural strength due to the use of optimum sol-gel admixtures for modifying the phenol-formaldehyde resin is theoretically substantiated and experimentally proved pre-cursor components of a nickel antioxidant. The technological parameters for the production of periclase-carbon refractories with specified physic-mechanical properties based on fused periclase with different amounts of graphite were determined using ETS-40 or its sol and nickel salts to create a complex antioxidant Al + SiC + Ni(NiO), which provides enhanced resistance to oxidation due to the formation of a dense layer of β-SiC and Ni(NiO) nanoparticles around graphite particles, a non-combustion technology and magnesia flux formulations for melting steel in a converter from waste periclase-carbon refractories lining of converters that accelerate guidance in the converter slag and improve the sustainability of the converter lining.
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Повшук, Василь Володимирович. "Нанозміцнені периклазовуглецеві вогнетриви для футерівки конвертерів з використанням комплексного антиоксиданту." Thesis, НТУ "ХПІ", 2018. http://repository.kpi.kharkov.ua/handle/KhPI-Press/37701.
Full textAbstract:
Дисертація на здобуття наукового ступеня кандидата технічних наук (доктора філософії) за спеціальністю 05.17.11 – технологія тугоплавких неметалічних матеріалів (161 – Хімічні технології та інженерія). – Національний технічний університет "Харківський політехнічний інститут", Харків, 2018.
Дисертація присвячена розробці складів та основних технологічних параметрів отримання нанозміцнених периклазовуглецевих вогнетривів для різних зон футерівки конвертера з заданими показниками фізико-механічних властивостей і підвищеною стійкістю до дії шлаку та до окиснення. У роботі теоретично обґрунтовано і експериментально доведено можливість одержання нанозміцнених периклазовуглецевих вогнетривів шляхом синтезу наповненої наночастинами β-SiC та NiO вуглецевої матриці-основи заданої структури периклазовуглецевих вогнетривів і забезпечення її максимальної струк-турної міцності за рахунок використання оптимальних співвідношень золь-гель добавок, що модифікують фенолформальдегідну смолу, і компонентів прекурсорів нікелевого антиоксиданту. Визначено технологічні параметри одержання периклазовуглецевих вогнетривів із заданими фізико-механічними властивостями на засаді плавленого периклазу і різною кількістю графіту, шляхом використанням ЕТС-40 або його золю та солей нікелю для створення комплексного антиоксиданту Аl + SiC + Ni(NiO), що забезпечує підвищену стійкість до окиснення за рахунок утворення щільного шару із наночастин β-SiC та Ni(NiO) навколо часток графіту, розроблено безвипалювану технологію та склади магнезіального флюсу для плавки сталі в конвертері з відходів периклазовуглецевих вогнетривів футеровок конвертерів, які сприяють прискоренню наведення шлаку в конвертері та підвищенню стійкості футерівки конвертера.Thesis for the degree of candidate of technical sciences (Ph.D.) in specialty 05.17.11 – technology of refractory nonmetallic materials (161 – chemical technologies and engineering). – National Technical University "Kharkov Polytechnic Institute", Kharkov, 2018. The thesis is devoted to the development of compositions and basic techno-logical parameters for the preparation of nano-reinforced periclase-carbon refractories for various zones of converter lining with prescribed parameters of physical and mechanical properties and increased resistance to slag and oxidation. The possibility of obtaining nano-reinforced periclase-carbon refractories by synthesis of the carbon-matrix matrix of a given structure of periclase-carbon refractories filled with nanoparticles β-SiC and NiO and ensuring its maximum structural strength due to the use of optimum sol-gel admixtures for modifying the phenol-formaldehyde resin is theoretically substantiated and experimentally proved pre-cursor components of a nickel antioxidant. The technological parameters for the production of periclase-carbon refractories with specified physic-mechanical properties based on fused periclase with different amounts of graphite were determined using ETS-40 or its sol and nickel salts to create a complex antioxidant Al + SiC + Ni(NiO), which provides enhanced resistance to oxidation due to the formation of a dense layer of β-SiC and Ni(NiO) nanoparticles around graphite particles, a non-combustion technology and magnesia flux formulations for melting steel in a converter from waste periclase-carbon refractories lining of converters that accelerate guidance in the converter slag and improve the sustainability of the converter lining.
Book chapters on the topic "ETS-40"
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Dutka-Mańkowska, Anna. "Des eff ets d’oralité dans des textes littéraires et leur traduction du français vers le polonais." In Regards sur l'oral et l'écrit. Warsaw University Press, 2015. http://dx.doi.org/10.31338/uw.9788323520689.pp.34-40.
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