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Relevant bibliographies by topics / Etamycin

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Academic literature on the topic 'Etamycin'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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Journal articles on the topic "Etamycin"

1

Hanh, Bui Thi Bich, Tae Ho Kim, June-Woo Park, Da-Gyum Lee, Jae-Sung Kim, Young Eun Du, Chul-Su Yang, Dong-Chan Oh, and Jichan Jang. "Etamycin as a Novel Mycobacterium abscessus Inhibitor." International Journal of Molecular Sciences 21, no. 18 (September 21, 2020): 6908. http://dx.doi.org/10.3390/ijms21186908.

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The increase in drug-resistant Mycobacterium abscessus, which has become resistant to existing standard-of-care agents, is a major concern, and new antibacterial agents are strongly needed. In this study, we introduced etamycin that showed an excellent activity against M. abscessus. We found that etamycin significantly inhibited the growth of M. abscessus wild-type strain, three subspecies, and clinical isolates in vitro and inhibited the growth of M. abscessus that resides in macrophages without cytotoxicity. Furthermore, the in vivo efficacy of etamycin in the zebrafish (Danio rerio) infection model was greater than that of clarithromycin, which is recommended as the core agent for treating M. abscessus infections. Thus, we concluded that etamycin is a potential anti-M. abscessus candidate for further development as a clinical drug candidate.

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2

Bateman, Kevin P., Keqian Yang, Pierre Thibault, Robert L. White, and Leo C. Vining. "Inactivation of Etamycin by a Novel Elimination Mechanism inStreptomyces lividans." Journal of the American Chemical Society 118, no. 23 (January 1996): 5335–38. http://dx.doi.org/10.1021/ja9539103.

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3

Haste, Nina M., Varahenage R. Perera, Katherine N. Maloney, Dan N. Tran, Paul Jensen, William Fenical, Victor Nizet, and Mary E. Hensler. "Activity of the streptogramin antibiotic etamycin against methicillin-resistant Staphylococcus aureus." Journal of Antibiotics 63, no. 5 (March 26, 2010): 219–24. http://dx.doi.org/10.1038/ja.2010.22.

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4

Sun, Peng, Katherine N. Maloney, Sang-Jip Nam, Nina M. Haste, Ritesh Raju, William Aalbersberg, Paul R. Jensen, Victor Nizet, Mary E. Hensler, and William Fenical. "Fijimycins A–C, three antibacterial etamycin-class depsipeptides from a marine-derived Streptomyces sp." Bioorganic & Medicinal Chemistry 19, no. 22 (November 2011): 6557–62. http://dx.doi.org/10.1016/j.bmc.2011.06.053.

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5

Hosoda, Koyama, Kanamoto, and Tomoda. "Discovery of Nosiheptide, Griseoviridin, and Etamycin as Potent Anti-Mycobacterial Agents against Mycobacterium avium Complex." Molecules 24, no. 8 (April 16, 2019): 1495. http://dx.doi.org/10.3390/molecules24081495.

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Mycobacterium avium complex (MAC) is a serious disease mainly caused by M. avium and M. intracellulare. Although the incidence of MAC infection is increasing worldwide, only a few agents are clinically used, and their therapeutic effects are limited. Therefore, new anti-MAC agents are needed. Approximately 6600 microbial samples were screened for new anti-mycobacterial agents that inhibit the growth of both M. avium and M. intracellulare, and two culture broths derived from marine actinomycete strains OPMA1245 and OPMA1730 had strong activity. Nosiheptide (1) was isolated from the culture broth of OPMA1245, and griseoviridin (2) and etamycin (viridogrisein) (3) were isolated from the culture broth of OPMA1730. They had potent anti-mycobacterial activity against M. avium and M. intracellulare with minimum inhibitory concentrations (MICs) between 0.024 and 1.56 μg/mL. In addition, a combination of 2 and 3 markedly enhanced the anti-mycobacterial activity against both M. avium and M. intracellulare. Furthermore, a combination 2 and 3 had a therapeutic effect comparable to that of ethambutol in a silkworm infection assay with M. smegmatis.

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6

Schlumbohm, W., and U. Keller. "Chromophore activating enzyme involved in the biosynthesis of the mikamycin B antibiotic etamycin from Streptomyces griseoviridus." Journal of Biological Chemistry 265, no. 4 (February 1990): 2156–61. http://dx.doi.org/10.1016/s0021-9258(19)39954-5.

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LAWRENCE, Christopher C., Wendy J. SOBEY, Robert A. FIELD, Jack E. BALDWIN, and Christopher J. SCHOFIELD. "Purification and initial characterization of proline 4-hydroxylase from Streptomyces griseoviridus P8648: a 2-oxoacid, ferrous-dependent dioxygenase involved in etamycin biosynthesis." Biochemical Journal 313, no. 1 (January 1, 1996): 185–91. http://dx.doi.org/10.1042/bj3130185.

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Proline 4-hydroxylase is a 2-oxoacid, ferrous-ion-dependent dioxygenase involved in the biosynthesis of the secondary metabolite etamycin. The purification, in low yield, of proline 4-hydroxylase from Streptomyces griseoviridus P8648 to near apparent homogeneity and its initial characterization are reported. In most respects proline 4-hydroxylase is a typical member of the 2-oxoacid-dependent dioxygenase family. It is monomeric (Mr approx. 38000) (by gel filtration on Superdex-G75) and has typically strict requirements for ferrous ion and 2-oxoglutarate. The enzyme was inhibited by aromatic analogues of 2-oxoglutarate. L-Proline-uncoupled turnover of 2-oxoglutarate to succinate and CO2 was observed. The addition of L-ascorbate did not stimulate L-proline-coupled turnover of 2-oxoglutarate, but did stimulate L-proline-uncoupled turnover. L-Ascorbate caused a time-dependent inhibition of L-proline hydroxylation. The enzyme was completely inactivated by preincubation with diethyl pyrocarbonate under histidine-modifying conditions. This inactivation could be partially prevented by the inclusion of L-proline and 2-oxoglutarate in the preincubation mixture, suggesting the presence of histidine residue(s) at the active site.

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8

Trenozhnikova, Lyudmila P., Almagul K. Khasenova, Assya S. Balgimbaeva, Galina B. Fedorova, Genrikh S. Katrukha, Nina L. Tokareva, Boo H. Kwa, and Azliyati Azizan. "Characterization of the Antibiotic Compound No. 70 Produced byStreptomycessp. IMV-70." Scientific World Journal 2012 (2012): 1–8. http://dx.doi.org/10.1100/2012/594231.

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We describe the actinomycete strain IMV-70 isolated from the soils of Kazakhstan, which produces potent antibiotics with high levels of antibacterial activity. After the research of its morphological, chemotaxonomic, and cultural characteristics, the strain with potential to be developed further as a novel class of antibiotics with chemotherapeutics potential was identified asStreptomycessp. IMV-70. In the process of fermentation, the strainStreptomycesspp. IMV-70 produces the antibiotic no. 70, which was isolated from the culture broth by extraction with organic solvents. Antibiotic compound no. 70 was purified and separated into individual components by HPLC, TLC, and column chromatography methods. The main component of the compound is the antibiotic 70-A, which was found to be identical to the peptolide etamycin A. Two other antibiotics 70-B and 70-C have never been described and therefore are new antibiotics. The physical-chemical and biological characteristics of these preparations were described and further researched. Determination of the optimal growth conditions to cultivate actinomycete-producer strain IMV-70 and development of methods to isolate, purify, and accumulate preparations of the new antibiotic no. 70 enable us to research further the potential of this new class of antibiotics.

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Dissertations / Theses on the topic "Etamycin"

1

Robinson, Kenneth J. "Bio-organic studies on proline 4-hydroxylase." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320660.

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Book chapters on the topic "Etamycin"

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Sheehan, John C., Hans Georg Zachau, and William B. Lawson. "The Chemistry of Etamycin." In Ciba Foundation Symposium - Amino Acids and Peptides with Antimetabolic Activity, 149–56. Chichester, UK: John Wiley & Sons, Ltd., 2008. http://dx.doi.org/10.1002/9780470719114.ch12.

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