Dissertations / Theses on the topic 'Espace de Cantor'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 dissertations / theses for your research on the topic 'Espace de Cantor.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.
Ghawadrah, Ghadeer. "Théorie descriptive des ensembles et espaces de Banach." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066078/document.
Full textThis thesis deals with the descriptive set theory and the geometry of Banach spaces.The first chapter consists of the study of the descriptive complexity of the set of Banachspaces with the Bounded Approximation Property, respectively π-property, in the set ofall closed subspaces of C(∆), where ∆ is the Cantor set. We show that these sets areBorel. In addition, we show that if α<ω_1, the set of spaces with Szlenk index at most α which have a shrinking FDD is Borel. We show in the second chapter that the numberof isomorphism classes of complemented subspaces of the reflexive Orlicz function space L^Φ [0,1] is uncountable, where L^Φ [0,1]is not isomorphic to L^2 [0,1]
Robert, Simon. "Une approche par les groupes amples pour l’équivalence orbitale des actions minimales de Z sur l’espace de Cantor." Electronic Thesis or Diss., Lyon 1, 2023. http://www.theses.fr/2023LYO10142.
Full textThis thesis takes place in the context of topological dynamics, a branch of dynamical systems concerned with the asymptotic qualitative behavior of continuous transformations arising from a group or semigroup action on a usually compact metric space. For example, a classic question might be whether a dynamical system admits recurrent points, i.e. points that will return arbitrarily close to their starting point infinitely often under the dynamics. Often, because of their qualitative and asymptotic nature, these properties do not depend precisely on the system but rather on the orbits of the points, i.e. the positions they will reach. Hence the notion of orbit equivalence at the heart of this thesis, which consists in considering that, after identification of the underlying spaces, two systems whose points all have the same orbits would be "qualitatively the same". In the 1990s, Giordano Putnam and Skau used homological algebra to establish a classification up to orbit equivalence of minimal dynamical systems arising from Z-actions on a Cantor space in terms of both full groups and invariant measures. This result shows in particular that there are non-countably many such different systems up to orbit equivalence, which contrasts quite strongly with the framework of ergodic theory, a very close field concerned with measured dynamical systems, in which the combination of two famous results, one due to Ornstein and Weiss and the other to Dye, shows that there is only one amenable group action on a standard probability space up to orbit equivalence. My main contribution in the present manuscript is to bring an elementary perpective and dynamical proofs to the classifications obtained by Giordano, Putnam and Skau (the one on orbital equivalence mentioned above as well as another one dealing with a variation called strong orbital equivalence), both in order to understand them from another perspective and to try to extend them to other contexts. Along the way, I will also prove a result of Borelian complexity, namely that the isomorphism relation of countable, locally finite and simple groups and a universal relation arising from a Borelian action of S_\infty, and improve a result of Krieger about the conjugation of ample groups
Le, Manach Florian. "Sur l’approximation et la complétude des translatés dans les espaces de fonctions." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0237/document.
Full textWe are interested in the study of cyclicity and bicyclicity in weighted $ell^p(Z)$ spaces and the study of cyclicity in Dirichlet spaces. While Wiener characterized the bicyclicity in $ell^1(Z)$ and $ell^2(Z)$, thanks to the zero set of the Fourier transform, Lev and Olevski have shown that this set cannot characterize bicyclicity in $ell^p(Z)$ when $1 < p < 2$ for sequences in $ell^1(Z)$. Also Beurling, Salem and Newman were interested in the bicyclicity in $ell^p(Z)$ when $1 < p < 2$. In this work, we first extend the results of Beurling, Salem and Newman to the weighted $ell^p(Z)$ spaces, by studying the Hausdorff dimension and the capacity of the zero set of the Fourier transform. Then we prove that the Lev-Olevskii result remains valid for cyclicity in $ell^p(Z)$, $1 < p < 2$. In addition, we give sufficient conditions for the cyclicity in the weighted $ell^p(Z)$ spaces. Finally, we prove that, for a function $f$ in the disk algebra and in a generalized Dirichlet space, if $f$ is outer and the zero set of $f$ is reduced to a point then $f$ is cyclic. This generalizes the result of Hedenmalm and Shields who have treated the case of the classical Dirichlet space
Milliet, Cédric. "Propriétés algébriques des structures menues ou minces, rang de Cantor Bendixson, espaces topologiques généralisés." Phd thesis, Université Claude Bernard - Lyon I, 2009. http://tel.archives-ouvertes.fr/tel-00442772.
Full textSouza, Sandra Elizabeth [UNESP]. "Dinâmica espaço-temporal de danos do cancro basal em Eucalyptus grandis." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/105452.
Full textEm três povoamentos de Eucalyptus grandis na região norte do Estado de São Paulo, foi realizado um estudo com objetivo de conhecer a dinâmica espaço-temporal do cancro basal, quantificar os danos no volume e efeito na qualidade da madeira. Foram instaladas nove parcelas de 7500 m², com 1000 árvores de E. grandis, procedência Santa Rita do P. Quatro-SP, origem Coffs Harbour, dos plantios seminais em solos de areia franca AQ1, AQ3 (10 a 15% de argila) e textura franco-argila-arenosa LEm2 (26 a 35% de argila). As avaliações foram realizadas em nove mil árvores com idade de dois anos. A incidência foi monitorada individualmente de acordo com a presença ou ausência da doença e a severidade, mediante o uso de uma escala diagramática de notas. Foram feitas avaliações nos anos 2000, 2001 e 2002, o que gerou 26 mapas de evolução da doença. Os resultados permitiram concluir que: (1) A incidência média do cancro basal foi influenciado pelo tipo de solo AQ3 (0,25%), AQ1 (0,21%) e LEm2 (0,09%); (2) Os valores do índice de dispersão (ID) foram > 1, para os tamanhos de quadrat 2x4, 5x2, 5x4 e 5x10; os valores de log (A) = log (Vobs) e log de (b) = log (Vbin) foram maiores que 1 e diferentes de zero, sugerindo uma tendência à agregação independente do tipo de solo; (3) 54,6% dos focos foram unitários, indicando que o cancro basal inicia-se com focos de apenas uma árvore; 80,8% dos focos apresentam maior comprimento na direção entre as linhas de plantio do que na direção da linha; focos maiores ocorreram no solo AQ3, que apresentaram-se menos compactos; a disseminação do cancro nesses povoamentos parece ter sido via sementes através das mudas; 89,1% dos mapas apresentaram focos com tamanho médio inferior a 10 árvores, no solo AQ3 em 10,9% dos focos o tamanho variou entre 11 a 30 árvores e nenhum foco foi formado acima de 30 árvores;...
A study was carried out in three Eucalyptus grandis stands in the northern region of the State of São Paulo, in order to provide information on the spatio-temporal dynamics of eucalyptus canker, evaluate volume losses, and determine the effect of the disease on wood quality. Nine 7500 m² plots (10×100) containing 1000 E. grandis trees from Santa Rita do P. Quatro-SP (origin: Coffs Harbour), in seed plantations on soils classified as loamy sands, AQ1 and AQ3 (10 to 15% clay), and on a silty-clay-loam-textured soil, LEm2 (26 – 35% clay). Evaluations were made in nine thousand two-year-old trees. Incidence was monitored individually according to the presence or absence of the disease. Severity was evaluated through the use of a diagrammatic rating scale. Evaluations were made in 2000, 2001, and 2002, and 26 disease progress maps were generated. The results allowed us to conclude that: (1) The mean incidence of eucalyptus canker followed a trend that matched the soil types:AQ3 (0.25%), AQ1(0.21.%), and LEm2 (0.09%); (2) The ID values were > 1 for quadrat sizes equal to 2×4, 5×2, 5×4, and 5×10; The log (A) = log (Vobs) and log (b) = log (Vbin) values were higher than 1 and different from zero, suggesting a tendency for aggregation, regardless of soil type; (3) 54.6% of the foci were single-unit, indicating that eucalyptus canker starts with single-tree foci; 80.8% of the foci had greater lengths between planting rows than along the rows; larger foci occurred in the AQ3 soil, which were less compact; canker dissemination in those stands seemed to have occurred via seeds through the seedlings; 89.1% of the maps had foci with mean sizes smaller than 10 trees in the AQ3 soil; in 10.9% of the foci the size ranged between 11 and 30 trees, and no focus formed at sizes above 30 trees; the ICF and ICFNU values were not close nor very far from ...(Complete abstract click electronic access below)
Souza, Sandra Elizabeth 1959. "Dinâmica espaço-temporal de danos do cancro basal em Eucalyptus grandis /." Botucatu : [s.n.], 2007. http://hdl.handle.net/11449/105452.
Full textBanca: Marli Teixeira de Almeida Minhoni
Banca: Claudio Angeli Sansígolo
Banca: Waldir Cintra de Jesus Junior
Banca: Celso Garcia Auer
Resumo: Em três povoamentos de Eucalyptus grandis na região norte do Estado de São Paulo, foi realizado um estudo com objetivo de conhecer a dinâmica espaço-temporal do cancro basal, quantificar os danos no volume e efeito na qualidade da madeira. Foram instaladas nove parcelas de 7500 m², com 1000 árvores de E. grandis, procedência Santa Rita do P. Quatro-SP, origem Coffs Harbour, dos plantios seminais em solos de areia franca AQ1, AQ3 (10 a 15% de argila) e textura franco-argila-arenosa LEm2 (26 a 35% de argila). As avaliações foram realizadas em nove mil árvores com idade de dois anos. A incidência foi monitorada individualmente de acordo com a presença ou ausência da doença e a severidade, mediante o uso de uma escala diagramática de notas. Foram feitas avaliações nos anos 2000, 2001 e 2002, o que gerou 26 mapas de evolução da doença. Os resultados permitiram concluir que: (1) A incidência média do cancro basal foi influenciado pelo tipo de solo AQ3 (0,25%), AQ1 (0,21%) e LEm2 (0,09%); (2) Os valores do índice de dispersão (ID) foram > 1, para os tamanhos de quadrat 2x4, 5x2, 5x4 e 5x10; os valores de log (A) = log (Vobs) e log de (b) = log (Vbin) foram maiores que 1 e diferentes de zero, sugerindo uma tendência à agregação independente do tipo de solo; (3) 54,6% dos focos foram unitários, indicando que o cancro basal inicia-se com focos de apenas uma árvore; 80,8% dos focos apresentam maior comprimento na direção entre as linhas de plantio do que na direção da linha; focos maiores ocorreram no solo AQ3, que apresentaram-se menos compactos; a disseminação do cancro nesses povoamentos parece ter sido via sementes através das mudas; 89,1% dos mapas apresentaram focos com tamanho médio inferior a 10 árvores, no solo AQ3 em 10,9% dos focos o tamanho variou entre 11 a 30 árvores e nenhum foco foi formado acima de 30 árvores;...(Resumo completo, clicar acesso eletrônico abaixo)
Abstract: A study was carried out in three Eucalyptus grandis stands in the northern region of the State of São Paulo, in order to provide information on the spatio-temporal dynamics of eucalyptus canker, evaluate volume losses, and determine the effect of the disease on wood quality. Nine 7500 m² plots (10×100) containing 1000 E. grandis trees from Santa Rita do P. Quatro-SP (origin: Coffs Harbour), in seed plantations on soils classified as loamy sands, AQ1 and AQ3 (10 to 15% clay), and on a silty-clay-loam-textured soil, LEm2 (26 - 35% clay). Evaluations were made in nine thousand two-year-old trees. Incidence was monitored individually according to the presence or absence of the disease. Severity was evaluated through the use of a diagrammatic rating scale. Evaluations were made in 2000, 2001, and 2002, and 26 disease progress maps were generated. The results allowed us to conclude that: (1) The mean incidence of eucalyptus canker followed a trend that matched the soil types:AQ3 (0.25%), AQ1(0.21.%), and LEm2 (0.09%); (2) The ID values were > 1 for quadrat sizes equal to 2×4, 5×2, 5×4, and 5×10; The log (A) = log (Vobs) and log (b) = log (Vbin) values were higher than 1 and different from zero, suggesting a tendency for aggregation, regardless of soil type; (3) 54.6% of the foci were single-unit, indicating that eucalyptus canker starts with single-tree foci; 80.8% of the foci had greater lengths between planting rows than along the rows; larger foci occurred in the AQ3 soil, which were less compact; canker dissemination in those stands seemed to have occurred via seeds through the seedlings; 89.1% of the maps had foci with mean sizes smaller than 10 trees in the AQ3 soil; in 10.9% of the foci the size ranged between 11 and 30 trees, and no focus formed at sizes above 30 trees; the ICF and ICFNU values were not close nor very far from ...(Complete abstract click electronic access below)
Doutor
Parreira, Paula Alexandra Ravasqueira. "Incidência do cancro do estômago e do pulmão : um estudo espacio-temporal na região sul de Portugal Continental entre 2000-2008." Master's thesis, Universidade Nova de Lisboa. Escola Nacional de Saúde Pública, 2011. http://hdl.handle.net/10362/9401.
Full textABSTRACT - Background/Objectives: Oncologic diseases are the second main cause of death in Portugal and have a strong impact, not only for its high incidence and mortality, but also by its strong psychosocial impact on patients and their families with significant repercussions in social and economic structures. According with previous studies, there are strong geographical disparities in the incidence of malignant disease. It is therefore essential characterize the spatiotemporal distribution in order to control the disease and promoting health, contributing to a better understanding of disease etiology. This project comprises three main objectives which are: the characterization of spatialtemporal distribution of lung cancer and stomach cancer, separately and together, in the southern region of mainland Portugal (covered by ROR-Sul) in the timeline from 2000 to 2008, seeking to identify potential areas of risk in developing these tumors. Methodology: Firstly was preformed a descriptive analysis of incidences ratios distribution by age, and gender, per year and per districts. After, with the objective to identify high incidence areas, it was preformed a spatiotemporal analyses, using spatial scan statistics, to identify significant clusters of high incidences. Results: Statistic descriptive showed that incidences of these particular cancers are higher in man than in woman, and the critical age group was 75+. The spatiotemporal analyzes showed high asymmetries in both cancer incidences. According these results was indentified three main clusters for stomach cancer and two main clusters for lung cancer in different periods of time (p ≤ 0,001). The lung cancer clusters are composed by municipalities from the regions of Lisboa, while the stomach cancer clusters, mainly include municipalities from the Alentejo region. Conclusions: The clustering analysis results showed a marked heterogeneity in the incidence of lung and stomach cancer among the different regions of the southern area of the country. Overall, the region that is considered at higher risk for developing stomach cancer is the interior region of Alentejo. Lisbon district is the region that presents a major risk for lung cancer developing.
Rosa, Fabíola. "Recantando muitos cantos: a música caipira como espaço de articulação de encontros." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/27/27157/tde-31052017-101546/.
Full textThis work intends to treat the caipira music, our object of research, from a transcultural point of view, where, in addition to showing its relation with the Portuguese, Indian and Black manifestations - already widely commented on in the bibliography on the subject, we will also look for traces , Or reminiscences, of Italian music. The phenomenon of Italian immigration in the early 20th century was part of a political project aimed at improving the moral conditions of Brazilian society. On the other hand, there were the inhabitants of the rural areas of the state of São Paulo, the Caipiras, who concentrated much of the characteristics considered undesirable for the urbanized intellectuals that aimed the progress of the country. Thus, thanks to the expansion of the large farms in the rural area of the state and the settlement of Italian colonies also inland, the Caipiras were exposed to coexistence with these Italian workers. We began to wonder how the referral of this mixture of cultures (native x Italian), specifically in music, would have taken place. We set out to find out what Italian would be in the music of the natives. We chose caipira music because it was a genre that came on the rise at a time when immigrants arrived in the country, so it was the musical manifestation of a group that was directly connected to the Italians. We believe that these events deserve even greater dedication on the part of the researchers, since they expressed the high degree of possibilities involved in the interaction of diverse cultures, these still need more collaborations that try to elucidate them.
Granados, Ybarra Gianinna Consuelo. "Articulando el espacio sanitario. Nuevo hospital para San Juan de Lurigancho – Canto Grande." Bachelor's thesis, Pontificia Universidad Católica del Perú, 2021. http://hdl.handle.net/20.500.12404/20252.
Full textLira, Andréa Braga de. "Utilização do espaço sonoro por quatro espécies de Hylidae do Cerrado no Brasil Central." reponame:Repositório Institucional da UnB, 2017. http://repositorio.unb.br/handle/10482/31258.
Full textSubmitted by Raquel Almeida (raquel.df13@gmail.com) on 2017-12-22T11:47:55Z No. of bitstreams: 1 2017_AndréaBragadeLira.pdf: 1918462 bytes, checksum: 9f8ebe94252d76685e51d6d9d91c4fbd (MD5)
Approved for entry into archive by Raquel Viana (raquelviana@bce.unb.br) on 2018-02-20T16:06:27Z (GMT) No. of bitstreams: 1 2017_AndréaBragadeLira.pdf: 1918462 bytes, checksum: 9f8ebe94252d76685e51d6d9d91c4fbd (MD5)
Made available in DSpace on 2018-02-20T16:06:27Z (GMT). No. of bitstreams: 1 2017_AndréaBragadeLira.pdf: 1918462 bytes, checksum: 9f8ebe94252d76685e51d6d9d91c4fbd (MD5) Previous issue date: 2018-02-20
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
Os processos de comunicação em anuros têm se sido foco de diversas pesquisas que avaliam interações inter-específicas e a maneira como as espécies utilizam o espaço acústico através do canto de anúncio. As características dos parâmetros do canto são de fato, importantes para a co-ocorrência de hilídeos em sítios de reprodução. Neste estudo, o período em que foi permitido obter o maior registro de gravações foi durante a estação chuvosa. Para todos os dados levantados em campo, os valores espectrais do canto se diferem quantos aos valores médios e ocupam espaços acústicos característicos. A sobreposição do nicho acústico foi menor que o esperado ao acaso, indicando que ocorra estruturação da assembléia no uso dos recursos. As taxas de repetição do canto foram explicadas por variáveis obtidas para cada indivíduo gravado, sendo elas: comprimento rostro-cloacal, temperatura e distância do animal para a água.
The processes of communication in anurans have been the focus of several researches that evaluate inter-specific interactions and the way in which the species use the acoustic space through the advertisement call. The characteristics of the call parameters are in fact important for the co-occurrence of hilídeos in breeding sites. In this study, the period in which it was allowed to obtain the largest recording record was during the rainy season. For all the data collected in the field, the spectral values of the call differ as much as the mean values and occupy characteristic acoustic spaces. The overlapping of the acoustic niche was less than expected at random, indicating that assembly structuring occurs in the use of resources. The rates repetition of call were explained by variables obtained for each recorded individual, being: rostrum-cloacal length, temperature and distance from the animal to the water.
Boufraqech, Myriem. "Implication des espèces réactives de l’oxygène (ROS) dans la radiocarcinogenèse thyroïdienne." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA11T069/document.
Full textRadiotherapy is used alone or in combination with chemotherapy to treat over 50% of cancers. Despite much progress in order to improve the benefit / risk ratio, the radiation causes many side effects. One of the known origins of thyroid cancer is exposure during childhood to ionizing radiation, either accidentally or as a result of external radiation therapy for another disease. The mechanisms by which ionizing radiation causes the appearance of thyroid cancer are numerous and not yet fully known. Ionizing radiations are genotoxic agents that induce DNA damage such as breaks and chromosomal aberrations. Although the mechanisms underlying these effects are not completely understood, it is generally accepted that ionizing radiations induce DNA damage either directly or indirectly by generating reactive oxygen species (ROS). During my PhD, we studied the role of ROS produced during irradiation in the generation of DNA damage in thyroid cells. Our results show that ROS produced after irradiation participate in the formation of RET/PTC1 rearrangements found in 70% of radiation-induced papillary cancers. ROS generated by radiolysis of water have a very short lifetime that limits their diffusion. However, by redox mechanisms, they cause changes at the cellular level, which in turn lead to the activation of ROS generating systems, which include the NADPH oxidases. Our results show that irradiation induces the expression of NADPH oxidase DUOX1 via the secretion of IL-13, several days after exposure to ionizing radiation. Inactivation of DUOX1 by interfering RNAs significantly reduces the DNA damage observed several days after irradiation. These results suggest a role DUOX1 in chronic oxidative stress that contributes to genetic instability
Moncheu, Kamga Koleber Victor. "Histiocytofibrome malin rétropéritonéal révélé par une thrombose veineuse cave inférieure : à propos d'une observation et revue de la littérature." Bordeaux 2, 1998. http://www.theses.fr/1998BOR2M011.
Full textTiradentes, Leomar [UNESP]. "O Canto da araponga: possibilidades de um turismo no espaço rural da microrregião de Viçosa - MG." Universidade Estadual Paulista (UNESP), 2004. http://hdl.handle.net/11449/95705.
Full textNa presente pesquisa analisamos as atividades turísticas em quatro propriedades rurais do Município de Araponga na Microrregião da Zona da Mata de Viçosa - MG, identificando suas diferentes realidades, seu processo de construção, desenvolvimento e compreensão quanto ao modo como elas interagem no espaço local. De caráter exploratório e de natureza qualitativa, utilizamos o estudo de caso como metodologia, tendo como instrumentos a observação e as entrevistas semi-estruturadas. O objetivo principal desta pesquisa foi analisar o turismo no espaço rural como fator de desenvolvimento das propriedades que já realizam algum tipo de oferta turística. Os resultados indicaram que as atividades turísticas estão inseridas na realidade das propriedades rurais, coexistindo com as práticas agropecuárias cotidianas, e com suas diferentes terminologias para as várias realidades turísticas no campo tais como pousada rural, camping, entre outras, que não abordam necessariamente a mesma modalidade de atividades. De maneira geral, o turismo no espaço rural encontra nas propriedades rurais pesquisadas, um local adequado para o seu pleno aproveitamento, desde que realizado de maneira planejada e responsável.
At the present research we analyse tourist activities in four rural properties of Araponga town at Zona da Mata Micro region of Viçosa in the state of Minas Gerais, it identifying your different realities, your construction process, development and understanding like they interact in the local space. Of exploring character and qualitative nature, we use the studying of case like methodology, it having like tools observation and interviews semi-structured. The main objective of this research was analyse tourism in rural space like development factor of properties have already made some kind of tourist offer. The results indicated that tourist activities are inserted in the reality of rural properties, it existing together with daily farming and cattle raising practices, it there being different terminologies to several tourist realities at the country like rural inn, camping, and others, it doesn't necessarily approaching the same kind of activities. In general, the tourism in rural space finds in researched rural properties an appropriate local to its full utilization since it put into practice in some planned and answerable way.
Gouvêa, Alana Adães de. "A casa mineira como um canto do mundo: da inocência de Taunay à universalidade do espaço." Centro de Ensino Superior de Juiz de Fora (CES/JF), 2017. https://repositorio.ufjf.br/jspui/handle/ufjf/6533.
Full textApproved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2018-04-03T19:05:02Z (GMT) No. of bitstreams: 1 alanaadaesdegouvea.pdf: 1119795 bytes, checksum: 2ad8c960d9e73e61f5e6a9c75b28625e (MD5)
Made available in DSpace on 2018-04-03T19:05:02Z (GMT). No. of bitstreams: 1 alanaadaesdegouvea.pdf: 1119795 bytes, checksum: 2ad8c960d9e73e61f5e6a9c75b28625e (MD5) Previous issue date: 2017-06-30
PROQUALI (UFJF)
A presente pesquisa pretende fazer um exame da obra Inocência, de Visconde de Taunay. Tal análise se apoia nos conceitos de espaço, como proposto pela fenomenologia de Gaston Bachelard e de hospitalidade, conforme o pensamento de Jacques Derrida. Esta investigação busca, portanto, demorar-se sobre a casa, enxergando-a como um espaço que sugere identidade ao ser humano e que está intimamente ligado à hospitalidade como ato que pressupõe o oferecimento de si e que torna a casa um canto do mundo. Como refletem Gaston Bachelard e Emmanuel Levinas, sua posse e uso transitam entre os sonhos e as necessidades não gerando, necessariamente, a intimidade do acolhimento. A partir do momento em que se considera que o texto literário é um dos lugares privilegiados dos estudos na busca da compreensão dos conflitos e das dúvidas que acometem o ser humano, essa pesquisa almeja evidenciar as peculiaridades e atualidades dos registros de Taunay, visualizando a casa do mineiro, os seus atrativos e os seus segredos. Assim, a partir do regional procura-se chegar a uma percepção do que se pode chamar de casa universal. Além disso, os seus cantos e (des)encantos, as suas características, os estranhamentos que acontecem quando nela se recebe o outro, oferecem as mais intrincadas e diversificadas simbologias. Isso porque a casa, embora fechada em si mesma, está aberta para o mundo, realçando o contraste entre o dentro e o fora, o eu e o outro, as partidas e chegadas. No que concerne a uma conceituação da hospitalidade frente a uma realidade de ontem e de hoje, pode-se demonstrar as incertezas do próprio conceito, a sua ambiguidade, a sua incondicionalidade e as suas consequências no trato público e pessoal das convivências e dos preceitos sociais. É nessa direção que o presente exame tem o seu lugar, qual seja, uma leitura de Inocência, buscando entender melhor o referencial da habitação, considerando as hipóteses apresentadas e contribuindo para o crescimento do acervo crítico de Visconde de Taunay.
The present research aims at making a study of the work Inocência, of Viscount of Taunay. This analysis is based on the concepts of space, as proposed by Gaston Bachelard's phenomenology and hospitality, according to the thinking of Jacques Derrida. This investigation, therefore, seeks to ponder over the house, seeing it as a space that suggests identity to the human being and that is intimately connected to hospitality as an act that presupposes the offering of oneself and that makes the house a corner of the world. As Gaston Bachelard and Emmanuel Levinas reflect, the possession and use of this place pass between dreams and needs, not necessarily generating the intimacy in the the reception. Since the literary text is considered to be one of the privileged places of studies in the search for an understanding of the conflicts and doubts that affect the human being, this research aims to highlight the peculiarities and the current features of the observations of Taunay , visualizing the house of Minas, its attractions and its secrets. So, starting out from the regional, one seeks to arrive at a perception of what can be called the universal house. In addition to this, the charms and the limitations, the characteristics and the strangeness that happens when they receive the other, offer the most intricate and diversified symbolisms. This is because the house, although closed in on itself, is open to the world, highlighting the contrast between inside and outside, self and other, departures and arrivals. With regard to a conceptualization of hospitality in the face of the reality of yesterday and today, one can demonstrate the uncertainties of the the concept itself, its ambiguity, its unconditionality and its consequences in the public and personal treatment of coexistence and of social precepts. It is in this direction then that the present examination takes its place, that is, a reading of Inocência, seeking to better understand the referential of the house, considering the hypotheses presented and contributing to the growth of the critical collection of the Viscount of Taunay.
Tiradentes, Leomar. "O Canto da araponga : possibilidades de um turismo no espaço rural da microrregião de Viçosa - MG /." Rio Claro : [s.n.], 2004. http://hdl.handle.net/11449/95705.
Full textBanca: Herbe Xavier
Banca: Sílvio Carlos Bray
Banca: Rita de Cássia Ariza da Cruz
Banca: Iandara Alves Mendes
Resumo: Na presente pesquisa analisamos as atividades turísticas em quatro propriedades rurais do Município de Araponga na Microrregião da Zona da Mata de Viçosa - MG, identificando suas diferentes realidades, seu processo de construção, desenvolvimento e compreensão quanto ao modo como elas interagem no espaço local. De caráter exploratório e de natureza qualitativa, utilizamos o estudo de caso como metodologia, tendo como instrumentos a observação e as entrevistas semi-estruturadas. O objetivo principal desta pesquisa foi analisar o turismo no espaço rural como fator de desenvolvimento das propriedades que já realizam algum tipo de oferta turística. Os resultados indicaram que as atividades turísticas estão inseridas na realidade das propriedades rurais, coexistindo com as práticas agropecuárias cotidianas, e com suas diferentes terminologias para as várias realidades turísticas no campo tais como pousada rural, camping, entre outras, que não abordam necessariamente a mesma modalidade de atividades. De maneira geral, o turismo no espaço rural encontra nas propriedades rurais pesquisadas, um local adequado para o seu pleno aproveitamento, desde que realizado de maneira planejada e responsável.
Abstract: At the present research we analyse tourist activities in four rural properties of Araponga town at Zona da Mata Micro region of Viçosa in the state of Minas Gerais, it identifying your different realities, your construction process, development and understanding like they interact in the local space. Of exploring character and qualitative nature, we use the studying of case like methodology, it having like tools observation and interviews semi-structured. The main objective of this research was analyse tourism in rural space like development factor of properties have already made some kind of tourist offer. The results indicated that tourist activities are inserted in the reality of rural properties, it existing together with daily farming and cattle raising practices, it there being different terminologies to several tourist realities at the country like rural inn, camping, and others, it doesn't necessarily approaching the same kind of activities. In general, the tourism in rural space finds in researched rural properties an appropriate local to its full utilization since it put into practice in some planned and answerable way.
Mestre
Dias, Alexandre Ferreira de Souza. "Competição por espaço acústico : adaptações de cantos de aves em uma zona de alta biodiversidade do Brasil Central." reponame:Repositório Institucional da UnB, 2013. http://repositorio.unb.br/handle/10482/14853.
Full textSubmitted by Albânia Cézar de Melo (albania@bce.unb.br) on 2013-12-12T15:24:04Z No. of bitstreams: 1 2013_AlexandreFerreiraSouzaDias.pdf: 3127038 bytes, checksum: 91fe39fbb3c020442ef7c35446d16b3a (MD5)
Approved for entry into archive by Guimaraes Jacqueline(jacqueline.guimaraes@bce.unb.br) on 2013-12-16T12:13:18Z (GMT) No. of bitstreams: 1 2013_AlexandreFerreiraSouzaDias.pdf: 3127038 bytes, checksum: 91fe39fbb3c020442ef7c35446d16b3a (MD5)
Made available in DSpace on 2013-12-16T12:13:18Z (GMT). No. of bitstreams: 1 2013_AlexandreFerreiraSouzaDias.pdf: 3127038 bytes, checksum: 91fe39fbb3c020442ef7c35446d16b3a (MD5)
Cada vez mais estudos têm mostrado que aves são capazes de modificar seu canto quando sujeitas a ruídos interferentes, sejam de fonte antrópica (como ruídos urbanos) ou biótica (cantos de outras aves). O presente estudo investigou comunidades de aves no Cerrado registradas com gravadores automáticos Song Meter e em regiões urbanas de Brasília gravadas com microfone direcional, analisando-se a influência de diferentes níveis de ruído urbano no canto de cinco espécies, e o grau de sobreposição da atividade de canto de cinco espécies durante o coro matutino em áreas de cerrado e borda de mata na Fazenda Água Limpa. Inicialmente apresentamos uma descrição do coro matutino, composto por 111 espécies, e a quantidade de espécies que exibem atividade vocal por estrato de tempo. Observamos uma tendência à redução no número de espécies entre 6h e 7h nas áreas de cerrado (r = -0.53, p = 0.07) e um aumento no número de espécies em áreas de borda de mata para o mesmo horário (r = 0.82, p = 0.001). A hipótese de que espécies com cantos com maior similaridade, ou seja, que utilizam bandas de frequência mais próximas, distribuem temporalmente os seus cantos de modo a não se sobreporem ao longo do tempo não se confirmou, porém encontramos indícios de particionamento do espaço acústico nos dados que indicam picos assincrônicos de atividade de canto para os pares de espécies Camptostoma obsoletum & Tyrannus melancholicus, e Cyclarhis gujanensis & Saltator similis gravadas em áreas de borda de mata. Já os resultados relativos às espécies gravadas em áreas urbanas mostraram uma correlação positiva significativa entre a frequência mínima do canto e o nível de ruído urbano para as espécies Troglodytes musculus (r = 0,67, p < 0.001), e Furnarius rufus (r = 0.46, p < 0.001). Por fim, foi analisada a eficácia do programa Song Scope em gerar reconhecedores automáticos para seis espécies. Para quatro espécies o programa apresentou um alto índice de detecções corretas (acima de 50%), enquanto que para duas delas, cujos cantos são mais complexos e mais variáveis, o índice de positivos verdadeiros foi abaixo de 30%. Tais dados mostram o alto potencial de reconhecedores automáticos para se avaliar comunidades de aves em áreas grandes onde o emprego de observadores humanos qualificados é limitado. ______________________________________________________________________________ ABSTRACT
A growing body of studies show that birds are capable of modifying their song when subject to interfering noises, either anthropogenic (e.g. urban noise) or biotic (songs from other birds). The present study investigated bird communities in the Cerrado biome recorded with Song Meter automatic equipment and in urban regions in Brasília, Brazil, recorded with a directional microphone, by analyzing the influence of different levels of urban noise on the song of five species, and the degree of overlap of singing activity between five species during the dawn chorus in cerrado and gallery forest edge areas at the Água Limpa Farm. Initially we present a description of the dawn chorus, comprising 111 species, and the number of species exhibiting vocal activity by time strata. We observed a trend towards reduction in the number of species vocally active between 6h and 7h in cerrado areas (r = -0.53, p = 0.07) and an increase in the number of species in gallery forest edge areas for the same period (r = 0.82, p = 0.001). The hypothesis that species with more similar songs, i.e. which sing in closer frequency bandwidths, distribute their songs temporally so that they do not overlap over time was not confirmed; however we found evidence of acoustic space partition in the data that indicate asynchronous peaks of song activity for the species pairs Camptostoma obsoletum & Tyrannus melancholicus, and Cyclarhis gujanensis & Saltator similis recorded in forest gallery areas. The results relative to species recorded in urban areas showed a positive significant correlation between minimum song frequency and the level of urban noise for the species Troglodytes musculus (r = 0,67, p < 0.001), and Furnarius rufus (r = 0.46, p < 0.001). Finally, we analyzed the effectiveness of the Song Scope software in generating automatic recognizers for six species. For four species the software showed high indexes of correct detections (above 50%), whereas for two of them, whose songs are more complex and more variable, the false positive index was below 30%. Such data show the high potential of automatic recognizers to evaluate bird communities in large areas where the use of qualified human observers is limited.
Jiao, Wenjuan. "APOBEC1 cytidine désaminase induit la mutagenèse de l'ADN chez différentes espèces animales." Thesis, Université de Paris (2019-....), 2019. http://www.theses.fr/2019UNIP7181.
Full textAPOBEC1 (A1) cytidine deaminases have a clear substrate preference for RNA. In addition, a few A1 enzymes have been shown to be active on single stranded DNA, mirroring the activities described for APOBEC3 enzymes. As human APOBEC3A (A3A), APOBEC3B (A3B) and related enzymes across the spectrum of placental mammals can introduce mutations in nuclear DNA leading to cancer genomes, we explored the mutagenic threat of A1 cytidine deaminases to chromosomal DNA.Using 3D-PCR to detect APOBEC specific GC to AT mutations, we demonstrated that A1 enzymes from the cow, pig, dog, rabbit and mouse have an intracellular ssDNA substrate specificity. However, only the mouse enzyme was able to introduce mutations into nuclear DNA. Interestingly, mouse A1 leaves the same dinucleotide editing context (5’TpC) as APOBEC3 like enzymes. These traits were paralleled by deamination of 5-methylcytidine substituted DNA by mouse A1 which is a feature of the mammalian A3A and A3B enzymes. Mouse A1 enzyme was far less efficient than human A3A and was closer to human A3B.At an experimental level mouse APOBEC1 is remarkable among 12 mammalian enzymes in that it represents a source of somatic mutations in mouse genome, potentially fueling oncogenesis. While the order of Rodentia is bereft of an A3A like enzyme it seems that APOBEC1 may well substitute for it, albeit remaining much less active. This modifies the paradigm that APOBEC3 and AID enzymes are the sole endogenous mutator enzymes giving rise to off-target editing of mammalian genomes
Silva, Suelen Umbelino da [UNESP]. "Modelo dinâmico bayesiano multivariado para análise espaço-temporal de dados de área." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/116005.
Full textModelagem de dados de área tem sido tema de diversas pesquisas em Estatística nas últimas décadas. Modelos espaço-temporais têm sido utilizados para lidar com esse tipo de dados de um modo natural, uma vez que muitas vezes envolvem processos que têm transições no tempo e no espaço. O avanço da tecnologia e, simultaneamente, de métodos estatísticos, têm permitido a elaboração de modelos cada vez mais estruturados para a descrição de fenômenos aleatórios complexos, cuja ideia é descrever, de forma realista, a estrutura de correlação presente nos dados, o que pode ser feito através do uso de modelos hierárquicos. Dada a importância atual da modelagem de fenômenos espaço-temporais, neste trabalho são estudadas propostas recentes apresentadas na literatura para dados espaciais de área, envolvendo modelos autorregressivos condicionais multivariados para capturar a estrutura espacial e modelos dinâmicos para capturar a estrutura temporal. Como aplicação da metodologia é estudada a distribuição espacial da mortalidade pelos cânceres de maior importância quantitativa, segundo as microrregiões administrativas do estado de São Paulo, considerando o período 1998 até 2010. Os resultados da aplicação de um modelo bayesiano hierárquico para os dados evidenciaram quais as regiões de maior risco de mortalidade no estado de São Paulo para cada um dos cânceres estudados, além de mostrar que existe forte correlação espacial entre algumas das doenças, o que constitui um resultado muito importante para os órgãos do sistema de saúde, que têm como função direcionar e alocar recursos para o tratamento e diagnóstico de tais doenças...
Data modeling area has been the subject of several studies in Statistics in recent decades. Spatio-temporal models have been used to deal with this kind of data in a natural way, since they often involve processes that have transitions in time and space. The advancement of technology and simultaneously statistical methods have allowed the development of increasingly structured models for the description of complex random phenomena, whose idea is to describe realistically, the structure of this correlation in the data, which can be done through the use of hierarchical models. Given the current importance of modeling spatio-temporal phenomena, the aim of this work is study recent paper that involve multivariate conditional autoregressive models to capture the spatial and dynamic structure models to capture the temporal structure. As an application of the methodology is the spatial distribution of mortality for cancers of greater quantitative importance studied, according to the administrative microregions of the state of São Paulo, considering the period 1998 to 2010...
Silva, Suelen Umbelino da. "Modelo dinâmico bayesiano multivariado para análise espaço-temporal de dados de área /." Presidente Prudente, 2014. http://hdl.handle.net/11449/116005.
Full textBanca: Leonardo Soares Bastos
Banca: Renato Martins Assunção
Resumo: Modelagem de dados de área tem sido tema de diversas pesquisas em Estatística nas últimas décadas. Modelos espaço-temporais têm sido utilizados para lidar com esse tipo de dados de um modo natural, uma vez que muitas vezes envolvem processos que têm transições no tempo e no espaço. O avanço da tecnologia e, simultaneamente, de métodos estatísticos, têm permitido a elaboração de modelos cada vez mais estruturados para a descrição de fenômenos aleatórios complexos, cuja ideia é descrever, de forma realista, a estrutura de correlação presente nos dados, o que pode ser feito através do uso de modelos hierárquicos. Dada a importância atual da modelagem de fenômenos espaço-temporais, neste trabalho são estudadas propostas recentes apresentadas na literatura para dados espaciais de área, envolvendo modelos autorregressivos condicionais multivariados para capturar a estrutura espacial e modelos dinâmicos para capturar a estrutura temporal. Como aplicação da metodologia é estudada a distribuição espacial da mortalidade pelos cânceres de maior importância quantitativa, segundo as microrregiões administrativas do estado de São Paulo, considerando o período 1998 até 2010. Os resultados da aplicação de um modelo bayesiano hierárquico para os dados evidenciaram quais as regiões de maior risco de mortalidade no estado de São Paulo para cada um dos cânceres estudados, além de mostrar que existe forte correlação espacial entre algumas das doenças, o que constitui um resultado muito importante para os órgãos do sistema de saúde, que têm como função direcionar e alocar recursos para o tratamento e diagnóstico de tais doenças...
Abstract: Data modeling area has been the subject of several studies in Statistics in recent decades. Spatio-temporal models have been used to deal with this kind of data in a natural way, since they often involve processes that have transitions in time and space. The advancement of technology and simultaneously statistical methods have allowed the development of increasingly structured models for the description of complex random phenomena, whose idea is to describe realistically, the structure of this correlation in the data, which can be done through the use of hierarchical models. Given the current importance of modeling spatio-temporal phenomena, the aim of this work is study recent paper that involve multivariate conditional autoregressive models to capture the spatial and dynamic structure models to capture the temporal structure. As an application of the methodology is the spatial distribution of mortality for cancers of greater quantitative importance studied, according to the administrative microregions of the state of São Paulo, considering the period 1998 to 2010...
Mestre
Sharif, Tanveer. "Étude des effets anticancéreux de polyphénols d'origine naturelle : rôle essentiel des espèces réactives de l'oxygène et des gènes suppresseurs de tumeurs." Thesis, Strasbourg, 2012. http://www.theses.fr/2012STRAJ103.
Full textThis research work shows that different sources of polyphenols (RWPs, AMJ and blackcurrant) have strong chemotherapeutic and chemopreventive effects on several cancer cells lines (acute lymphoblastic leukemia and cancer stem cells) and also in vivo in a model of tumorigenesis in mouse. These polyphenols inhibit the proliferation of various cancer cells by inducing cell cycle arrest and apoptosis. The anti-cancer effect is dependent on the induction of oxidative stress involving superoxide anions and hydrogen peroxide which, in turn, activate the signaling pathways leading to the re-expression of tumor suppressor genes such as p73 and p53 and executor of apoptosis such as caspase 3. This study also shows that polyphenols control the proliferation of cancer cells at epigenetic level by decreasing the expression of UHRF1 (an epigenetic integrator of proliferation). Moreover, the anticancer effect of these polyphenols is selective towards cancer cells and not in normal cells. Fractionation of these rich sources of polyphenols and studies on the commercially available pure products shows that anti-cancer effects of these polyphenols involve several different compounds. This study leads to the identification of cyaniding-3-O-glucoside and cyaniding-3-O-rutinoside as active anticancer compounds
Boufraqech, Myriem. "Implication des espèces réactives de l'oxygène (ROS) dans la radiocarcinogenèse thyroïdienne." Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00747797.
Full textTeixeira, Paulo Frederico de Andrade. "Performance da obra coral de Osvaldo Lacerda: rigor de escrita e o espaço do intérprete." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/27/27158/tde-18092018-164248/.
Full textThis thesis is part of the doctoral work in Musical Performance with specialization in Choral Conducting for the Post-Graduation Program in Music of the Escola de Comunicações e Artes da Universidade de São Paulo. During the four doctoral years, concerts, rehearsals and practices were undertaken simultaneously with the writing of this text which discusses questions regarding the practice of a performer. Our main object is the relationship between musical writing and performance. As interpreters, we seek to understand what the creative spaces and their limits within a work of music are. In order to do this, the choral work of the Brazilian composer Osvaldo Lacerda - known for his rigorous and rather indicative writing - was used. After a reflection on the conflicts between composition and interpretation, a general critical analysis of the compositional writing of Lacerda was carried out to identify the spaces for the creativity of the interpreter. Next, an in-depth analysis was carried out on four compositions by Osvaldo Lacerda: Automação, Romaria, and O Papagaio and the movement Uníssono of the work Quatro Estudos para Coro. The analyzed works were presented during the doctoral period together with the Chamber Choir Comunicantus and we could form, test and consolidate our interpretative conceptualizations, as is commented and justified throughout the text. Lastly, we point to some answers regarding the creative space in the performance of an extremely indicative piece and about the responsibility of the interpreter to the sheet music.
Andigué, Job. "Mise en place d'un système d'information géographique comme base d'une stratégie pour une meilleure gestion des espaces ruraux : cas du canton de Bongor rural au sud-ouest du Tchad." Paris 1, 1999. http://www.theses.fr/1999PA010638.
Full textThe objective to better manage the natural resources existing in the extension command area of the european development fund (edf), located in the Chad basin and comprising a territory of 31 000 km2 with two rivers, the chari and the logone, and the southern banks of the Chad lake, has led us to develop a geographical information system (gis). The locality of bongor has been chosen as a pilot area for this project. The above mentioned objective has been reached due to the application of an original method which has been developed to deal with the eleventh themes necessary to build the geographical data base of the gis. The crossing of thematic maps elaborated on the basis of an analysis of aerial photographs taken in 1974 and of a spot image hrv in 1994 has given new and more accurate information, on the evolution of the natural environment of this area in the past twenty years. Theses documents created with two programs being connected, it was therefore possible to access and use the information stocked in the both. This experiment tested on a large geographical scale can be applied to other rural areas. To ensure the good elaboration and use of such an geographical information, some new propositions have been suggested
Bana, Émilie. "Inhibition des phosphatases CDC 25 dans le cadre d'une thérapie anticancéreuse : étude mécanistique de nouveaux inhibiteurs." Thesis, Université de Lorraine, 2013. http://www.theses.fr/2013LORR0105/document.
Full textWithin the context of research for new targets for cancer therapy, Cdc25 phosphatases are interesting candidates, the inhibition of which being able to slow down tumor growth and eventually improve the cancer treatments currently in use. The objectives of this PhD project are to design and synthesize new compounds able to inhibit CDC25 and to determine efficiency of identified compounds in breast cancer cell lines. In vitro evaluation of inhibitory potential of compound is realized through a high sensitivity fluorometric method (3-OMFP substrate). Cellular effects were evaluated in MCF-7 and MDA-MB-231 cell lines. Effects on cell viability are assessed through MTT assays, and cytotoxicity is evaluated through trypan blue assays and microscopic observations with Incucyte videomicroscopy system. Cell death was characterized by detection of apoptotic markers (caspases) and DNA damages markers (PARP Histone H.2AX) by Western Blotting. The analyses of mechanisms underlying cell death were explored through cytometric detection of reactive oxygen species (ROS) with H2DCFDA and Redox Sensor Red probes. Inhibition of CDC25 in cells was indirectly evaluated through detection of phosphorylated forms of CDK by Western Blotting. In vitro evaluation of 93 synthesized compounds allowed us to find new active compound in various chemical families including steroid, thiophene, coumarinic, imidazole and quinone derivatives. The coumarinic derivatives showed potent CDC25 inhibition. A new coumarin-sulfurquinone combined structure, named SV37, was designed to optimize efficiency of inhibition. In vitro tests on this compound, showed a strong CDC25 inhibitory potential (IC50 under 5µM for CDC25 A and C). Effect of SV37 on cell growth was evaluated on various cell lines (MCF-7, MDA-MB-231, hTERT-HME1 and HepG2). Results indicate inhibition of cell growth (IC50 values from 9 to 18 µM). Analysis of cell viability indicates no remarkable cell death in MCF7 at IC50 value whereas in MDA-MB-231 the cell growth decrease was characterized by an increase of cell death. For deeper investigations on the cell death and on the underlying mechanisms, we focused the study on the triple negative model MDA-MB-231. The morphological changes of MDA-MB-231 cells during the treatment were characterized by the appearance of cellular alterations compatible with a cellular demise and culminating with a disruption of cells after 20h. Caspase-3 and 7 cleavages were observed 16h after beginning of the treatment, suggesting an apoptotic cell death. A ROS induction was observed 15 min after the beginning of the treatment and was totally prevented by Nacetylcysteine (NAC) pretreatment. DNA damage markers were detected between 16 and 28 hours after beginning of treatment, a timing falling with caspase activation and with the appearance of cell demise observed by video microscopy. Accumulation of pCDK in cells was observed after 4 and 8 hr of treatment by SV37 at IC50 suggesting an inhibition of CDC25 activity, and cells pretreated with NAC showed no accumulation of pCDK after SV37 treatment. This strongly suggests a direct link between ROS generation by the compound SV37 and the accumulation of pCDK. This project increased knowledge on inhibitors of CDC25 phosphatases and allowed the identification of coumarine compound as new CDC25 inhibitors. This work will enable the development of ever more efficient inhibitors, leading to efficient inhibition of CDC25 and inhibition of tumor development
Niocel, Mathilde. "Caractérisation des fonctions cellulaires du facteur de restriction viral APOBEC3A." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSEN017/document.
Full textAPOBEC3A (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like editing complex 3 A) belongs to a family of cytidine deaminases that can edit cytidines to uraciles. APOBEC3G (model protein for the family) is a restriction factor for HIV: since it’s incorporated in the viral particle, it can deaminate the newly formed viral genome leading to hypermutation and viral DNA degradation.A3A is not incorporated in the viral particle: this protein is specifically expressed in myeloid cells where it is harmless for the cell and edits the DNA of the incoming viral particle in the same way than A3G.Physiologically, in non-myeloid cells, APOBEC3s deaminate single strand cellular DNA and the resulting uraciles are cut out by UNG2. These abasic sites are cleaved by the DNA repair machinery and can generate double strand breaks that will result in cell death.The objective of the thesis was to understand this difference of behaviour between different cell types. For that purpose, A3A-inducible cell lines were created in HeLa and U937 (monocytic) cells. The results obtained indicate that partially nuclear A3A edits the genomic DNA of cycling cells, leading to DNA damage, to the production of reactive oxygen species (ROS) and to cell death. Differentiated cells do not present this type of damage and that phenotype can be explained by a different localization of the protein.These results link for the first time DNA damage induced by a member of the A3 proteins family to ROS production and to induction of an immune activation. This activation could have implications in infection as well as in tumorigenic processes
Lima, Renato Ribeiro de. "Modelagem espaço-temporal para dados de incidência de doenças em plantas." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/11/11134/tde-23052005-164227/.
Full textThe information about the spatial-temporal dynamics is of fundamental importance in epidemiological studies for describing and understanding the development of diseases, for developing efficient sampling plans, for planning controlled experiments, for evaluating the effect of different treatments, and for determining crop losses. The Citriculture is the major economic activity of more than 400 municipalities in Minas Gerais and São Paulo States. This is the largest citrus area in Brazil, and the largest sweet orange production area in the world. Therefore, it is very important to study and to characterize spatial patterns of plant diseases, such as citrus canker and citrus sudden death. In the spatial dynamics study, many different methods have been used to characterize the spatial aggregation. These include the fitting of distributions, such as the beta-binomial distribution, the study of variance-mean relationships, the calculation of intraclass correlation, the use of spatial autocorrelation techniques, distance class methods and, the fitting of continuous time spatiotemporal stochastic models. In this work, an improved technique for fitting models to the spatial incidence data by using MCMC methods is proposed. This improved technique, which is used to investigate the spatial patterns of plant disease incidence, is considerably faster than Gibsons methodology, in terms of computational time, without any loss of accuracy.
Brown, Ahumada Carolina. "El Poema de Fernán Gonzáles y el Cantar de Roldán: La ‘mala imagen’ del moro en la épica española y francesa." Tesis, Universidad de Chile, 2005. http://repositorio.uchile.cl/handle/2250/110271.
Full textSeminario de grado: Desde la escritura: imágenes y representaciones del Islam y los musulmanes
El Poema de Fernán González y El Cantar de Roldán: La ‘mala imagen’ del moro en la épica española y francesa, consiste en la revisión de dos famosos poemas épicos: El Cantar de Roldán y el Poema de Fernán González, textos canónicos de la literatura medieval. Esta investigación se centrará en el estudio de la manera en que los personajes ‘moros’ o ‘sarracenos’ son representados en estas obras, tomando en cuenta tanto sus características físicas como morales y sicológicas. Asimismo, se tendrá en especial consideración la caracterización de su religión.
Paviot, Arnaud. "La guitare flamenca de 1920 à nos jours." Thesis, Tours, 2017. http://www.theses.fr/2017TOUR2033/document.
Full textIn imaginary as well than in practice, guitar and flamenco music are inseparable . This alliance last for more than a century and half. From the Andalusian melting pot, flamenco has little by little formed himself. At first festive art from private parties, he went out to find new places of representation. That was the cafés-cantantes, then the competitions, then the opéras-flamencos. He was sometimes the object of controversy and of debates between defenders of modernity and tradition. Flamenco is an immediately identifiable music for a profane auditor. But he is constituted of an important numbers or forms or of form family. This study object is to show recurrences in the forms – the palos – to be able to identify the form by rhythmical, literary and musical analysis, particularly basing itself on the guitar playing
Sáez, Rosenkranz Isidora. "Movimiento populares, siglos XIX y XX. "Soy campesino y soy cantor", la fiesta de la Cruz de Mayo, un espacio de sociabilidad y conformación de identidad campesina, aculeo 1960-2005." Tesis, Universidad de Chile, 2005. http://repositorio.uchile.cl/handle/2250/110191.
Full textTumura, Karina Goulart [UNESP]. "Dinâmica espaço-temporal, quantificação de danos e perdas e influência do cancro (Chrysoporthe cubensis) no acúmulo de biomassa e fixação de carbono em seis genótipos de eucalyptus spp." Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/145519.
Full textA cultura do eucalipto é uma das mais importantes do Brasil, constituindo-se em fonte de energia e madeira renovável, suportando importantes processos agroindustriais, dentre eles, a produção de celulose, papel e essências. O eucalipto, como outras espécies vegetais, é infectado por diversos patógenos, principalmente fungos, desde o viveiro até plantios adultos. Neste trabalho, será estudado o agente causador do cancro basal, Chrysoporthe cubensis. Esta doença possui ampla distribuição geográfica, ocorrendo desde o extremo sul do Estado de São Paulo até a Amazônia, observando-se prejuízos em regiões de baixa altitude de Espírito Santo, do Vale do rio Doce em Minas Gerais e Recôncavo Baiano. Sua sintomatologia é bastante variada, podendo atacar plantas de cinco meses de idade até o final da rotação. As plantas jovens, por apresentarem diâmetros reduzidos, podem ser aneladas na sua base pelo cancro, sendo levadas à morte. Do ataque em plantas mais velhas resultam lesões com pouco ou abundante trincamento até cancros típicos, podendo ser encontrados a diversas alturas do tronco. O local escolhido para a realização do trabalho, foi a área do projeto EUCFLUX, onde estão implantadas parcelas experimentais com 16 materiais genéticos, em diferentes condições de solo e altitude. Os estudos sobre a influência de doenças no acúmulo de biomassa e fixação de carbono são escassos, sendo assim, os objetivos desse trabalho foram: a) verificar a suscetibilidade ao cancro basal dos seis clones com maior produtividade utilizados nas parcelas experimentais do EUCFLUX; b) proceder o estudo espaço-temporal da doença e c) verificar a influência do cancro basal no acúmulo de biomassa e fixação de carbono das plantas atacadas. Foram avaliadas três repetições quanto à incidência da doença, sendo que tais dados formaram a base para a análise espaço-temporal...
Eucalyptus' culture is one of the most important in Brazil being a source of renewable energy and wood. In addition, it supports important agro-industrial processes for the production of pulp, paper and essences. Eucalyptus, like any other plant species, can be infected by many pathogens, especially fungi, from nurseries to adult plantations. In this work, the causal agent of basal canker, Chrysoporthe cubensis, were studied. This disease has a wide geographical distribution, occurring from the southern end of São Paulo State to the Amazon, observing sensitive damages in low-lying regions of Espírito Santo State, Rio Doce Valley in Minas Gerais State and Reconcavo Baiano. Its symptons are quite varied and the fungi can attack plants from five months of age until the end of forest rotation. Young plants with small diameters may be girdled at their base by canker, being put to death. Attack in older plants may result in low or heavy typical cankers, that can be found at different heights of the trunk. The work was conducted in the area of EUCFLUX project, which were established with 16 clones in 10 experimental plots with different soil conditions and elevation. Studies of disease influence in carbon fixation and biomass accumulation are scarce, therefore, the objectives of this work were: a) verify the susceptibility to basal canker of the six clones with higher productivity used in experimental plots of EUCFLUX; b) conduct the spatiotemporal study of the disease and; c) verify the influence of basal canker in the accumulation of biomass and carbon fixation of the attacked plants. Incidence of the disease were evaluated in three plots and these data were the basis for spatiotemporal analysis. To determine biomass parameters, inventory was done in the same three plots and volume and biomass equations were adjusted. In addition, specific gravity of the wood and bark were calculated to healthy ...
Tumura, Karina Goulart 1983. "Dinâmica espaço-temporal, quantificação de danos e perdas e influência do cancro (Chrysoporthe cubensis) no acúmulo de biomassa e fixação de carbono em seis genótipos de eucalyptus spp. /." Botucatu, 2015. http://hdl.handle.net/11449/145519.
Full textBanca: Martha Maria Passador
Banca: Christiane Ceriani Aparecido
Banca: Luiz Alberto Blanco Jorge
Banca: Waldir Cintra de Jesus Junior
Resumo: A cultura do eucalipto é uma das mais importantes do Brasil, constituindo-se em fonte de energia e madeira renovável, suportando importantes processos agroindustriais, dentre eles, a produção de celulose, papel e essências. O eucalipto, como outras espécies vegetais, é infectado por diversos patógenos, principalmente fungos, desde o viveiro até plantios adultos. Neste trabalho, será estudado o agente causador do cancro basal, Chrysoporthe cubensis. Esta doença possui ampla distribuição geográfica, ocorrendo desde o extremo sul do Estado de São Paulo até a Amazônia, observando-se prejuízos em regiões de baixa altitude de Espírito Santo, do Vale do rio Doce em Minas Gerais e Recôncavo Baiano. Sua sintomatologia é bastante variada, podendo atacar plantas de cinco meses de idade até o final da rotação. As plantas jovens, por apresentarem diâmetros reduzidos, podem ser aneladas na sua base pelo cancro, sendo levadas à morte. Do ataque em plantas mais velhas resultam lesões com pouco ou abundante trincamento até cancros típicos, podendo ser encontrados a diversas alturas do tronco. O local escolhido para a realização do trabalho, foi a área do projeto EUCFLUX, onde estão implantadas parcelas experimentais com 16 materiais genéticos, em diferentes condições de solo e altitude. Os estudos sobre a influência de doenças no acúmulo de biomassa e fixação de carbono são escassos, sendo assim, os objetivos desse trabalho foram: a) verificar a suscetibilidade ao cancro basal dos seis clones com maior produtividade utilizados nas parcelas experimentais do EUCFLUX; b) proceder o estudo espaço-temporal da doença e c) verificar a influência do cancro basal no acúmulo de biomassa e fixação de carbono das plantas atacadas. Foram avaliadas três repetições quanto à incidência da doença, sendo que tais dados formaram a base para a análise espaço-temporal...
Abstract: Eucalyptus' culture is one of the most important in Brazil being a source of renewable energy and wood. In addition, it supports important agro-industrial processes for the production of pulp, paper and essences. Eucalyptus, like any other plant species, can be infected by many pathogens, especially fungi, from nurseries to adult plantations. In this work, the causal agent of basal canker, Chrysoporthe cubensis, were studied. This disease has a wide geographical distribution, occurring from the southern end of São Paulo State to the Amazon, observing sensitive damages in low-lying regions of Espírito Santo State, Rio Doce Valley in Minas Gerais State and Reconcavo Baiano. Its symptons are quite varied and the fungi can attack plants from five months of age until the end of forest rotation. Young plants with small diameters may be girdled at their base by canker, being put to death. Attack in older plants may result in low or heavy typical cankers, that can be found at different heights of the trunk. The work was conducted in the area of EUCFLUX project, which were established with 16 clones in 10 experimental plots with different soil conditions and elevation. Studies of disease influence in carbon fixation and biomass accumulation are scarce, therefore, the objectives of this work were: a) verify the susceptibility to basal canker of the six clones with higher productivity used in experimental plots of EUCFLUX; b) conduct the spatiotemporal study of the disease and; c) verify the influence of basal canker in the accumulation of biomass and carbon fixation of the attacked plants. Incidence of the disease were evaluated in three plots and these data were the basis for spatiotemporal analysis. To determine biomass parameters, inventory was done in the same three plots and volume and biomass equations were adjusted. In addition, specific gravity of the wood and bark were calculated to healthy ...
Doutor
Lavergne, Lucie, and Lucie Lavergne. "L'écriture poétique, d'espaces et de rythmes : regards croisés sur six recueils de la poésie hispanophone contemporaine : Rubén Darío, Cantos de vida y esperanza (1905) ; Juan Ramón Jiménez, Diario de un poeta reciencasado (1916) ; Rafael Alberti, Marinero en tierra (1924) ; Vicente Aleixandre, Espadas como labios (1932) ; Pere Gimferrer, Arde el mar (1966) ; Leopoldo María Panero, Teoría (1973)." Phd thesis, Université Blaise Pascal - Clermont-Ferrand II, 2011. http://tel.archives-ouvertes.fr/tel-00942945.
Full textBlein, Sophie. "Étude de la variabilité du génome mitochondrial comme facteur de susceptibilité au cancer du sein." Thesis, Lyon 1, 2014. http://www.theses.fr/2014LYO10240/document.
Full textA large part of the genetic component of breast cancer risk (BCR) is still unexplained. Therefore I studied if variants of the mitochondrial genome (mtDNA) might explain a part of this risk. In fact, mitochondria is the main source of reactive oxygen species (ROS), which contribute to genomic instability and tumor development. As a first axis of research, I studied potential interactions between some nuclear and mitochondrial variants, in conjugation to alcohol consumption. Despite the large dimensions of our dataset, the lack of statistical significant interaction in our data might reveal that former published results that show such interactions were not robust. I also studied if mitochondrial haplogroups could be considered as modificators of known association between BCR and pathogenic mutations in the BRCA1/2 genes. I identified haplogroup T1a1 such as modificator for individuals carrying a mutated BRCA2. Finally, I characterized by NGS mitochondrial genome of women diagnosed for a familial breast cancer, but tested negative for known pathogenic BRCA1/2 mutations. Several variants were identified as potentially damaging. Two genes, MT-ATP6 and MT-CYB are specifically enriched both in terms of distinct variants and in the number of individuals carrying these variants. They are both essential structural components of the mitochondrial respiratory chain, the main ROS production source in the cell. All these analyses contribute to enrich the knowledge about associations between BCR and variability of mtDNA, by integrating questions linked to interactions between genomic variants, environmental exposure, and effect modifications related to mitochondrial haplogroups
Lu, Cong. "Analyse microélectrochimique du stress oxydant à l'échelle de la cellule unique : application aux cellules cancéreuses du sein." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2012. http://tel.archives-ouvertes.fr/tel-00828217.
Full textAssi, Mohamad. "L'impact de l'activité physique et des antioxydants sur le dialogue entre la tumeur et le muscle squelettique dans le cancer : déchiffrage de voies de signalisation impliquées dans la croissance de la tumeur et l'atrophie musculaire." Thesis, Rennes 2, 2016. http://www.theses.fr/2016REN20055/document.
Full textReactive oxygen species (ROS) control several aspects of carcinogenesis as they can either promote tumor growth andprogression or senescence and apoptosis. In advanced stages of cancer, ROS can also drive the development of other cancerrelated complications like, muscle wasting. Physical activity (PA) and antioxidant supplementation have been proposed as two adjuvant strategies to better control tumor growth, ameliorate performance and alleviate secondary symptoms related to cancer itself or to the heavy anticancer therapies. However, several issues remain to be elucidated. First of all, although PA could reduce colon, breast and prostate cancer growth and progression, its impact remains unknown on orthotopic intramuscular tumors like liposarcoma, which directly affect the musculoskeletal apparatus and reduce physical function. Secondly, given the limitedness of PA application in some advanced stages of cancer, patients may increase their dependency on nutritional and antioxidant complements as an alternative strategy, but such practice has spark a lot of polemic and inconsistent results. In this thesis, we have addressed the effectiveness of PA and antioxidants in two distinct animal models of cancer. Using in vivo and in vitro approaches, we found that voluntary PA accelerated the growth of intramuscular liposarcoma tumors and exacerbated skeletal muscle dysfunction, mainly, by decreasing circulating insulin levels and the subsequent activation of the tumor suppressor pathway “P38 MAPK-P21”. We also demonstrated that nutritional doses of commercial antioxidants enhanced colon tumor growth, total body/skeletal muscle weight loss and caused premature death of mice. Such mechanism was due to selective changes in oxidative damage profiles, which decreased in tumor but increased in skeletal muscle, in a way driving tumor growth and skeletal muscle wasting/dysfunction. Clinically, it seems that (1) patients with intramuscular liposarcoma may, at least, not increase their levels of PA or undergo hospital-supervised exercise program, during the preoperative period; until the confirmation of our findings with clinical data and (2) patients with advanced stages of cancer must be very careful against the use of antioxidants as it could lifethreatening. Accordingly, health agencies in France, Europe and USA prohibit the use of synthetic antioxidant supplements without dietary counseling by a cancer patient’s physician and/or nutritionist
Julienne, Cloé Mimsy. "Altérations du métabolisme énergétique mitochondrial lors de la cachexie cancéreuse." Thesis, Tours, 2012. http://www.theses.fr/2012TOUR3318/document.
Full textCancer cachexia is a composite syndrome, characterized by a negative energetic balance. The role played by mitochondrial energetic metabolism in this syndrome is poor known. Our past work showed a decrease of ATP synthesis efficiency in hepatic mitochondria in severe state of cancer cachexia. In this work, we demonstrate, in vitro, that increase of reactive oxygen species and cardiolipine content, in healthy mitochondria, can partly mimic the mechanisms observed in severe state of cancer cachexia. We observe that alteration of hepatic mitochondrial metabolism appear last during the development of cancer cachexia. In sever state of cancer cachexia, skeletal muscle mitochondria don’t develop this alteration but demonstrated a decrease of oxidative capacities
Loiseau, Philippe. "Etude structurale et geostatistique des gneiss de la region du cezallier : modelisation tridimensionnelle de reseaux de fractures, application a l'ecoulement des fluides." Orléans, 1987. http://www.theses.fr/1987ORLE2055.
Full textMontanha, Dionize. "Análise espacial e temporal do câncer de mama na região metropolitana da Baixada Santista e sua relação com áreas contaminadas." Universidade Católica de Santos, 2017. http://biblioteca.unisantos.br:8181/handle/tede/3901.
Full textMade available in DSpace on 2017-08-22T17:16:28Z (GMT). No. of bitstreams: 1 Dionize Montanha.pdf: 3874925 bytes, checksum: 5c564d4d796cab82f040686e592599c4 (MD5) Previous issue date: 2017-06-21
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES
Breast cancer defies the world public health mainly by the high incidence and mortality of the disease. The Metropolitan Region of the Santos Area (RMBS) stands out for presenting high levels of mortality of the disease, as well as various environmental contaminants classified as carcinogens. The research has the objective of analyzing the temporal and spatial distribution of breast cancer in the Metropolitan Region of the Santos Area. Methodology: It is a mixed ecological study (spatial and temporal), about the distribution of breast cancer in the cities of RMBS, as well as in the regions exposed to environmental contaminants and regions of the state of Sao Paulo from 2000 to 2011. The population was composed by women at 20 years old or over, and data was provided by Oncocentro Foundation of Sao Paulo (FOSP), and from the contaminated areas, data was obtained from the Environmental Sanitation Technology Company (CETESB). Data about the population at risk was provided by the State System of Data Analysis (SEADE). The total number of breast cancer cases in the years from 2000 to 2011 was 87.354, 830 cases were excluded being: 779 cases of males over 20 years, and 51 cases under the age of 20 years (4 males and 47 females). From the total of 86.524 followed, 3.233 were in RMBS. Annual standardized coefficients of breast cancer were built to each city in RMBS and to each Regional Health Department (DRS) in the state of Sao Paulo. In order to characterize exposure a density indicator of density of contamination per city was built, for the analysis of the correlation between breast cancer and environmental contamination was utilized the correlation of Pearson. The analysis of variables was realized through Statistical Package for the Social Sciences, version 15.0 (SPSS). Through linear regression, a time trend analyses was done, and to that end SPSS and the Statistics or Windows 8.0 were also used. To the Spatial analyzes, four levels of coefficient intervals of breast cancer were created. A sequential cartographic was developed that reveals the distribution and the spatial-temporal evolution of outcome and exposure. Results: The results show that in RMBS the city with the highest levels of breast cancer is the city of Santos. The correlation of Pearson was positive, with r=0.7 and significance level of p=0,036. In the spatial part, the most contaminated areas presented the highest rates of breast cancer, except for the city of Peruíbe, where, despite low environmental containment, numbers showed high rates of the disease. By means of linear regression, the tendency analysis was done in all counties signaling growth of the disease, with exception of Bertioga county where the tendency is the reduction of the disease. When compared the breast cancer rates of RMBS with the DRS of the São Paulo State, certain regions showed much higher rates as: Araraquara, Araçatuba, Barretos, Bauru, Marília, Ribeirão Preto, São José do Rio Preto and Piracicaba, and the last cited region presented the highest levels of breast cancer in the State of São Paulo. This study confirms the hypothesis that environmental contamination interferes with the distribution of breast cancer, and the time trends indicates an increase in the disease in eight of the nine cities in the region.
O câncer de mama desafia a saúde pública mundial principalmente pela alta incidência e mortalidade da doença. A Região Metropolitana da Baixada Santista (RMBS) destaca-se por apresentar elevadas taxas de mortalidade da doença, assim como diversos contaminantes ambientais classificados como cancerígenos. A pesquisa tem por objetivo analisar a distribuição temporal e espacial do câncer de mama na Região Metropolitana da Baixada Santista. Metodologia: Trata-se de um estudo ecológico misto (espacial e temporal), sobre a distribuição do câncer de mama nos municípios da RMBS, assim como nas regiões expostas a contaminantes ambientais e regiões do Estado de São Paulo de 2000 a 2011. A população foi composta por mulheres de 20 anos ou mais, e os dados foram fornecidos pela Fundação Oncocentro de São Paulo (FOSP), e das áreas contaminadas, os dados foram obtidos pela Companhia de Tecnologia de Saneamento Ambiental (CETESB). Dados sobre a população em risco foram fornecidos pelo Sistema Estadual de Análise de Dados (SEADE). O total de casos de câncer de mama dos anos de 2000 a 2011 foi de 87.354, foram excluídos 830 casos sendo: 779 casos do sexo masculino maiores de 20 anos, e 51 casos menores de 20 anos (4 masculinos e 47 femininos). Do total de 86.524 utilizados, 3.233 foram na RMBS. Foram construídos coeficientes padronizados anuais de câncer de mama para cada município da RMBS e para cada Departamento Regional de Saúde (DRS) do Estado de São Paulo. Para caracterizar a exposição foi construído um indicador de densidade de contaminação por município, para a análise da correlação entre taxas de câncer de mama e contaminação ambiental foi utilizada a correlação de Pearson. A análise das variáveis foi realizada por intermédio do Statistical Package for the Social Sciences, versão 15.0 (SPSS). Por intermédio da regressão linear, foi feita a análise da tendência temporal, e para isso utilizou-se também o SPSS e o Statistics for Windows 8.0. Para a análise espacial, foram criadas quatro categorias de intervalos de coeficientes de câncer de mama. Foi desenvolvido o sequenciamento cartográfico que revela a distribuição e a evolução espacial-temporal de desfecho e exposição. Resultados: Os resultados mostram que na RMBS o município com taxas mais elevadas de câncer de mama é o município de Santos. A correlação de Pearson apresentou-se positiva, com um r=0.7 e nível de significância de p=0,036. Na parte espacial, as áreas mais contaminadas apresentaram as maiores taxas de câncer de mama, exceto no município de Peruíbe que, apesar do baixo índice de contaminação ambiental, apresentou altas taxas da doença. Por meio da regressão linear, foi feita a análise de tendência em todas as cidades sinalizando aumento da doença, com a exceção da cidade de Bertioga, onde a tendência é a de redução da doença. Quando comparadas as taxas de câncer de mama da RMBS com os DRS do Estado de São Paulo, algumas regiões apresentaram taxas bem superiores como: Araraquara, Araçatuba, Barretos, Bauru, Marília, Ribeirão Preto, São José do Rio Preto e Piracicaba, sendo que a última região citada apresentou as maiores taxas de câncer de mama do Estado de São Paulo. Esse estudo confirma a hipótese de que a contaminação ambiental interfere na distribuição do câncer de mama, e a tendência temporal sinaliza aumento da doença em oito dos nove municípios da região.
Anjos, Cristineide dos. "O familiar acompanhante da criança e a equipe de enfermagem no centro de terapia intensiva pediátrico oncológico: um espaço de interação no cuidado de enfermagem." Universidade Federal Fluminense, 2015. https://app.uff.br/riuff/handle/1/1679.
Full textMade available in DSpace on 2016-05-04T17:45:29Z (GMT). No. of bitstreams: 1 Cristineide dos Anjos.pdf: 2616100 bytes, checksum: e94501195ff76b65226f80d3a2453fdc (MD5) Previous issue date: 2015
Mestrado Acadêmico em Ciências do Cuidado em Saúde
O estudo teve como objetivo geral analisar os limites e possibilidades da presença do familiar acompanhante no cuidado à criança com câncer no centro de terapia intensivo pediátrico oncológico e como objetivos específicos: descrever o cuidado à criança no centro de terapia intensivo pediátrico oncológico na visão da equipe de enfermagem e do familiar acompanhante; identificar a visão da equipe de enfermagem sobre a presença do familiar acompanhante no centro de terapia intensiva pediátrico oncológico e conhecer como o familiar acompanhante vê sua presença no centro de terapia intensivo pediátrico oncológico. Trata-se de pesquisa de natureza qualitativa, do tipo estudo de caso, realizado no centro de terapia intensiva pediátrico oncológico de um hospital de referência no tratamento de câncer localizado na Cidade do Rio de Janeiro. A produção de dados envolveu as técnicas de observação simples, com registros em diário de campo, e entrevista semiestruturada com 25 membros da equipe de enfermagem e 10 familiares acompanhantes de crianças com câncer internadas no referido centro de terapia intensiva. Após organização e identificação dos dados, estes foram submetidos à análise temática de conteúdo segundo Bardin, emergindo-se as seguintes categorias: O familiar da criança com câncer até a entrada no centro de terapia intensivo pediátrico oncológico e as interações do familiar acompanhante e membros da equipe de enfermagem no cuidado à criança com câncer no Centro de Terapia Intensiva Oncológico. A partir dos depoimentos dos familiares acompanhantes e da equipe de enfermagem constatou-se que no cuidado a criança hospitalizada no CTIP a interação entre ambos favorece sua adaptação ao ambiente, que envolve inúmeros procedimentos e rotinas, demandando suporte emocional e conforto viabilizado pela presença do familiar e conhecimento técnico e científico da equipe de enfermagem. Assim, conclui-se que o centro de terapia intensivo pediátrico oncológico representa um espaço de interação do familiar acompanhante com a equipe de enfermagem no cuidado a criança com câncer, fundamentado na escuta atenta, viabilizada pelo diálogo que possibilita a troca de conhecimentos do familiar da criança com sua experiência, sentimentos e expectativas. Tal processo tem início com o adoecimento e conta com a equipe de enfermagem que tem como meta o cuidado integral à mesma, incluindo suporte e orientações ao familiar da criança, elemento fundamental no seu processo de hospitalização e tratamento.
The study aimed to analyze the limits and possibilities of the presence of an accompanying family member in the care of children with cancer in the pediatric oncologic intensive care unit and as specific objectives: to describe the care of children in the pediatric oncologic intensive care unit in the nursing team and companion family member´s point of view; identify the nursing team´s point of view about the presence of an accompanying family member in the pediatric oncologic intensive care unit and to know how the accompanying family member sees his presence in the pediatric oncologic intensive care unit. It´s a qualitative research, a case study, carried out at the pediatric oncologic intensive care unit of a reference hospital in the treatment of cancer located in the city of Rio de Janeiro. The data production involved the simple observation techniques, with records in field diary, and semi-structured interview with 25 members of the nursing team and 10 accompanying family members of hospitalized children with cancer in that intensive therapy unit. After data identification and organization, these were submitted to thematic content analysis according to Bardin, emerging the following categories: the family of the child with cancer to the entrance in the pediatric oncologic intensive care unit and the family member´s interactions and nursing team members in the care for children with cancer in the Oncologic Intensive Care Unit. From the testimonies of the accompanying family members and nursing team we found that in the care of children hospitalized in the CTIP interaction between them favors its adaptation to the environment, involving numerous procedures and routines, requiring emotional support and comfort made possible by the familiar member presence and scientific and technical knowledge of the nursing team. Thus, it is concluded that the pediatric oncologic intensive care unit is an accompanying family member interaction space with the nursing team in care of children with cancer, based on attentive listening, made possible by dialogue that enables the exchange of the knowledge of the family member with his experience, feelings and expectations. This process begins with the illness and has the nursing team that aims to the comprehensive care to it, including support and guidance to the child's family, a key element in the process of hospitalization and treatment.
Homberg, Nicolas. "New models and algorithms for the identification of sncRNA-(snc)RNA interactions intra and across-species/kingdom." Electronic Thesis or Diss., Lyon 1, 2023. http://www.theses.fr/2023LYO10090.
Full textMicroRNAs (miRNAs) are non-coding RNAs present in eukaryotes that regulate the expression of messenger RNAs (mRNAs) up or down. These miRNAs have significant potential in future treatment of cancer and other diseases. The miRNA-mRNA interactions are intricate and involve various mechanisms, such as sequence complementarity, accessibility, and conservation. This thesis focuses on two such mechanisms, namely accessibility and intra-species conservation of the site of interaction, using experimental data from Cross-linking, Ligation And Sequencing of Hybrids (CLASH). Although the accessibility of interaction sites on mRNAs is generally observed, it is not consistent for all interactions. Intra-species conservation is a rare feature, which we explore by inferring conserved motifs from mRNA interaction sites. Although the results are noisy, in some specific cases, we manage to retrieve some mRNA interaction sites from the inferred motifs
Ildefonse, Philippe. "Analyse petrologique des alterations premeteoriques et meteoriques de deux roches basaltiques (basalte alcalin de belbex, cantal, et hawaiite de m'bouda, cameroun)." Paris 7, 1987. http://www.theses.fr/1987PA077118.
Full textLavergne, Lucie. "L’écriture poétique, d’espaces et de rythmes : regards croisés sur six recueils de la poésie hispanophone contemporaine : Rubén Darío, Cantos de vida y esperanza (1905) ; Juan Ramón Jiménez, Diario de un poeta reciencasado (1916) ; Rafael Alberti, Marinero en tierra (1924) ; Vicente Aleixandre, Espadas como labios (1932) ; Pere Gimferrer, Arde el mar (1966) ; Leopoldo María Panero, Teoría (1973)." Thesis, Clermont-Ferrand 2, 2011. http://www.theses.fr/2011CLF20021/document.
Full textThrough the combined analysis of six poem books of contemporary Spanish poetry, this thesis aims to define poetic writings and its rhythm. Rhythm is considered in relation with the notion of space. Starting with the traditional association of rhythm and meter, the first part studies how the metrical space of the writing of verses, with its structures and boundaries, involves the law and its transgression. On the other hand, the second part considers space as a “substance”: poetic writing is analyzed through its development in the language and sentences. Centered on the figure of the “line”, the second conception of rhythm also implies temporality, which is included in the words themselves (the verbs) and generated by the combination of the sentences. However, in the poem books, sometimes linearity is deconstructed by different phenomenon that deal with language (the dissolution of syntaxes), verse (the enjambment, the dissemination on various lines), and the page. The last chapter is dedicated to the visibility of writing on the page. As a concretization of the writing act, the page is also a revelation of the writer of the poem. Our third and last part is centered on the subject, its different faces and representations. Rhythm appears, at last, as a mosaic of discursive and semantic spaces that imply the speaker as much as the reader
Abdelaziz, Salih. "Développement d'un système robotique pour la radiologie interventionnelle sous IRM." Phd thesis, Université de Strasbourg, 2012. http://tel.archives-ouvertes.fr/tel-00801844.
Full textChauvin, Julie. "Etude des mécanismes anti-cancéreux induits par milieux activés par jet de plasma froid : vers une nouvelle approche thérapeutique." Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30263/document.
Full textCancer therapies based on physical principles (radiofrequency, ultrasound, laser, electroporation...) have considerably increased in the last decade. Their objectives are to directly destroy cancer cells, to favor the targeted entry of therapeutic molecules or to stimulate the patient's immune system in order to eliminate the tumor. Cold plasma still arouses interest in the field of oncology through its ability to generate reactive oxygen species (ROS) and nitrogen species (RNS) which can be genotoxic and cytotoxic for cancer cells. Two approaches to the use of plasma are studied: either direct exposure of cells to the plasma jet, or indirect exposure via the use of a Plasma Activated Medium (PAM). The PAM being easier to deliver by injection into the tumor, this approach was chosen in this work. The work presented consists in studying the genotoxic and cytotoxic effects of PAM resulting from exposure of the medium to the helium plasma jet on in vitro and in vivo tumors. For in vitro studies, we chose to use a 3D model: the spheroid (MCTS - MultiCellular Tumor Spheroid). This model has similar characteristics to the in vivo model thanks to its spheroidal organization. The spheroids have indeed gradients of oxygen penetration, nutrients and cell proliferation. The first part of the thesis concerns the identification and quantification of the species generated in PAM. The analytical methods used are paramagnetic electronic resonance, fluorimetry, colorimetry, liquid chromatography and mass spectrometry. These analyses revealed that the toxicity of PAM was due to several factors: on the one hand to the generation of ROS and RNS and on the other hand to the degradation of cell nutrients contained in the medium via, for example, the oxidation and nitrosylation of the amino acids. The second part is dedicated to the study of the effects of PAM on HCT-116 (colon cancer) spheroids[...]
Minig, Vanessa. "Etude du mécanisme de régulation du gène et de l'importance biologique de la superoxyde dismutase à manganèse dans la croissance tumorale mammaire." Thesis, Nancy 1, 2009. http://www.theses.fr/2009NAN10032/document.
Full textManganese superoxide dismutase (Mn SOD or SOD2) is an important enzyme in the antioxidizing defence, which seems to play an unclear role in the cancer development, according to the constitutive expression of its gene. However, the regulation of this constitutive expression is not totally known, particularly in the breast cancer cells. This work is based on a preliminary revealing that a protein, called Damaged DNA Binding 2 (DDB2), specifically binds the SOD2 gene promoter. The DDB2 is known for its involvement in the nucleotide excision repair. At first step, we characterized the specific DNA sequence recognized in the proximal area of the SOD2 gene promoter, on which a DDB2 monomer binds, in order to regulate negatively the Mn SOD transcription in the MCF-7 non metastatic breast cancer cells. Besides, DDB2 is not involved in the mechanism of SOD2 gene induction, when MCF-7 cells are exposed to induced substances. However, we showed that the lack of the DDB2 protein, associated with the lack of the AP-2a transcription factor, already known as a repressor of the SOD2 gene, lead to a high Mn SOD constitutive expression in the metastatic breast cancer cells. Furthermore, this high constitutive expression is mainly dependent of the Sp1 transcription factor. Secondly, we estimated the biological meaning of the regulation of the Mn SOD constitutive expression by the DDB2 in the breast cancer cells. Our results show that the DDB2 activates the positive ER breast cancer cell proliferation, by exercising its negative regulation on the Mn SOD expression. Thirdly, we tried to show the consequences on the negative ER breast cancer cell growth, which naturally and highly express the Mn SOD. Our results reveal that the antioxidizing enzyme plays an important role in the molecular mechanisms involved in the invasive capacities of the negative ER breast cancer cells. The high Mn SOD expression, associated in a decrease of the H2O2 detoxifying enzymes expression, enhance the negative ER breast cancer cell invasion and an increase of the matrix metallopeptidase-9 activity. The H2O2 elimination, with specific antioxidants, decreases both negative ER breast cancer cell growth and invasive capacities. This whole work contributes to better understand the Mn SOD importance and the mechanism of its gene regulation, in the tumoral growth and invasion. This work also reveals the Mn SOD and DDB2 as potential predictive factors of the breast cancer progress. Finally, the discovery of this new DDB2 biological activity opens a huge field of interesting perspectives in breast cancer research
Charbonnel, Marie. "Materialibus ad immaterialia : Peinture murale et piété dans les anciens diocèses de Clermont, du Puy et de Saint-Flour du XIIe au XVe siècle." Thesis, Clermont-Ferrand 2, 2012. http://www.theses.fr/2012CLF20005.
Full textWall-painting is viewed as a material medium of communication deeply linked to the places of worship and devotion that are churches. As a part of this place et by its monumental character, it forms a privileged way of spread for messages which addressees belong to terrestrial and celestial spheres. Those religious places and spaces, which wall painting is a good part, should consequently be viewed by taking account of its function and attendance. This dissertation proposes to envisage medieval religious practices through the prism of wall painting of the former dioceses of Clermont, Le Puy and Saint-Flour (1317). At first, the political and religious frameworks, historiography of the studies on wall painting and the problematic are exposed. Secondly, questionings induced by murals linked to spaces used by believers and clerical communities are developed. Thirdly, questionings inherent to murals inserted in material environment of the pious foundation, which serve as setting for liturgical or non liturgical prayers, and which are included in an individual and/or family context, are treated. The aim of this study is to consider iconographic and epigraphic expressions within private and community frameworks. Indeed, issues are very different, notably at levels as signs of identity and iconographic themes as portrait
Rochwert-Zuili, Patricia. ""Du poème à l'histoire. La geste cidienne dans l'historiographie alphonsine et néo-alphonsine (XIIIe-XIVe siècles)"." Phd thesis, Université Paris-Nord - Paris XIII, 1998. http://tel.archives-ouvertes.fr/tel-00130804.
Full textVauzour, David. "Étude des propriétés biologiques des constituants des vins de Champagne." Phd thesis, Université Montpellier I, 2004. http://tel.archives-ouvertes.fr/tel-00460764.
Full textHe, Tiantian. "Studying the Role of Peroxiredoxin 1 in ROS Modulation and Drug Resistance." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA112139.
Full textPeroxiredoxins have multiple cellular functions as major antioxidants, signaling regulators, molecular chaperones and tumor suppressors. Peroxiredoxin 1 (Prx1) is the most abundant among the six isoforms of human peroxiredoxins. It is frequently over-expressed in various cancer cells, which is known associated with carcinogenesis, metastasis and resistance to radiotherapy or chemotherapy. Prx1 could thus be an interesting anticancer target. In this study, we first evaluated the impact of Prx1 knockdown (Prx1–) on cellular sensitivity to dozens of anticancer drugs including vinblastine, taxol, doxorubicin, daunorubicin, actinomycin D, and 5-fluorouracil, and of reactive oxygen species (ROS)-generating agents, including hydrogen peroxide, 2-phenylethyl isothiocyanate, β-lapachone (β-lap) and menadione. We observed that Prx1 knockdown significantly enhanced cancer cell sensitivity to β-lap and menadione, two naphthoquinones with anti-cancer activity.We first investigated the underlying mechanisms responsible for the specifically enhanced cytotoxicity to β-lap in a Prx1 knockdown context. Prx1 knockdown markedly potentiated β-lap-induced cytotoxicity through ROS accumulation. This effect was largely NAD(P)H:quinone oxidoreductase 1 (NQO1)-dependent and associated with the phosphorylation of c-Jun N-terminal kinases (JNK), protein 38 (p38) and extracellular signal-regulated kinases (Erk) proteins in mitogen-activated protein kinase (MAPK) pathways, and a decrease in thioredoxin 1 protein levels. Based on the fact that Prx1 is a major ROS scavenger and a partner of apoptosis signaling kinase 1 (ASK1) and JNK, two key components of MAPK pathways, we propose that Prx1 knockdown-induced sensitization to β-lap is achieved through the combined action of ROS accumulation and MAPK pathway activation, leading to cell apoptosis.We then investigated the underlying mechanisms responsible for the specifically enhanced cytotoxicity to menadione in Prx1– cells. Enhanced sensitivity to menadione was associated with a rapid and significant intracellular ROS accumulation and necroptotic-like cell death. Menadione-induced ROS accumulation occurred immediately in the cytosol, the nucleus, and even more noticeably in the mitochondrial matrix, correlated with significant oxidation of both mitochondria-localized thioredoxin 2 and peroxiredoxin 3. Prx1 knockdown significantly up-regulated mRNA and protein levels of NRH: quinone oxidoreductase 2 (NQO2). Increased activity of NQO2 was largely responsible for menadione-induced ROS accumulation and consequent cell death. Our data indicate that massive ROS accumulation results from the combined effect of increased ROS generation by higher NQO2 activity during menadione metabolism, and diminished Prx1 scavenging activity. Finally and noteworthy, the metabolic pathways that lead to ROS accumulation, downstream signaling pathways and cell death mechanisms appear to be distinct for β-lap and menadione
Pierre, Anne-Sophie. "Le métabolisme des acides gras monoinsaturés et la prolifération des cellules cancéreuses coliques : rôle de la Stéaroyl-CoA Désaturase-1 et effets des isomères conjugués de l'acide linoléique." Phd thesis, Université de Bourgogne, 2012. http://tel.archives-ouvertes.fr/tel-01017782.
Full text