Journal articles on the topic 'Esophagus Diseases Treatment'
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Drobyazgin, E. A., Yu V. Chikinev, and I. E. Sudovikh. "ENDOSCOPIC INTERVENTIONS IN THE PATHOLOGY OF ARTIFICIAL ESOPHAGUS." VESTNIK KHIRURGII IMENI I.I.GREKOVA 177, no. 4 (September 8, 2018): 15–18. http://dx.doi.org/10.24884/0042-4625-2018-177-4-15-18.
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The OBJECTIVE of the study is to assess the possibilities of using endoscopic techniques in the treatment of diseases of the artificial esophagus. MATERIAL AND METHODS. Esophagoplasty for benign diseases of the esophagus was performed in 184 patients. 73 patients were diagnosed with diseases of the artificial esophagus and underwent various endoscopic interventions. RESULTS. Restoring patency of the anastomosis was achieved in all cases of esophageal anastomotic stenoses (68). No complications were observed. Endoscopic interventions in other diseases of the artificial esophagus allowed improving the quality of life, restoring patency or preparing the patient for intervention. CONCLUSION. Endoscopic methods of treatment of diseases of the artificial esophagus are highly effective, allowing to restore patency of the artificial esophagus and esophageal anastomoses. These interventions should be carried out in the specialized departments.
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Berdnikov, S. I., A. B. Salmina, V. V. Salmin, N. S. Rudaya, and E. V. Semichev. "The evolution of approaches to the diagnosis and treatment of patients with Barrett’s esophagus." Experimental and Clinical Gastroenterology, no. 3 (June 22, 2020): 102–7. http://dx.doi.org/10.31146/1682-8658-ecg-175-3-102-107.
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Barrett’s esophagus is one of the most serious complications of gastroesophageal reflux disease also known as GERD. Late diagnosis and treatment cause a high risk of developing adenocarcinoma of the esophagus with the background of Barrett’s esophagus. Today, this condition is one of the most controversial diseases of the gastrointestinal tract (GIT), requiring a careful approach to diagnosis and treatment by a group of specialists, including an endoscopist, gastroenterologist and pathologist. This article is a review of the literature on the history and current aspects of the diagnosis and treatment of Barrett’s esophagus.
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Kastenmeier, Andrew, Hiram Gonzales, and Jon C. Gould. "Robotic Applications in the Treatment of Diseases of the Esophagus." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 22, no. 4 (August 2012): 304–9. http://dx.doi.org/10.1097/sle.0b013e318258340a.
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Sharapov, T. L., V. I. Fedorov, M. V. Burmistrov, E. I. Sigal, M. V. Aglullina, and K. V. Kholomanova. "RETROSPECTIVE ANALYSIS OF MINIMALLY INVASIVE METHODS OF TREATMENT OF NEUROMUSCULAR DISEASES OF THE ESOPHAGUS (ACHALASIA OF CARDIA, CARDIOSPASM)." Oncology bulletin of the Volga region 13, no. 3 (2022): 34–38. http://dx.doi.org/10.32000/2078-1466-2022-3-34-38.
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Most neuromuscular diseases of the esophagus (achalasia of the cardia, cardiospasm) lead to a decrease in the quality of life of patients, leading to symptoms such as difficulty in passing solid and liquid food through the esophagus (dysphagia 1-4 degrees), regurgitation, in some cases chest pain, with severe coughing and weight loss. The etiology remains unknown. Currently, there is no single standard for the treatment of patients with neuromuscular diseases of the esophagus. This work was carried out in order to assess the immediate and long-term results of surgical treatment of patients with neuromuscular diseases of the esophagus. The article presents an analysis of the results of repeated operations in 34 patients after surgical treatment of achalasia of the cardia and cardiospasm, conducted on the basis of the oncological department №2 of the RCOD (Kazan) and thoracic department №2 of the RCH of the Ministry of Health of the Republic of Tatarstan. Total on the basis of the oncology department № 2 of the RCOD (Kazan) and Thoracic Department №2 of the RCH of the Ministry of Health of the Republic of Tatarstan performed 353 minimally invasive surgical interventions for neuromuscular diseases of the esophagus (achalasia of the cardia and cardiospasm). The data of patients depending on gender, age and data of patients who needed and did not need repeated endosurgical treatment are presented. The 20-year experience of surgical treatment with the use of minimally invasive techniques in patients diagnosed with Achalasia of the cardia and cardiospasm was evaluated. The causes of relapses in both achalasia of the cardia and cardiospasm are analyzed, and the long-term results of repeated operations are presented.
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Доржиев, Bair Dorzhiev, Воскресенская, Marina Voskresenskaya, Плеханов, Aleksandr Plekhanov, Цыремпилов, and Sergey Tsyrempilov. "Prospects of phytopreparations based on Calendula officinalisin complex treatment of chemical burn of the esophagus." Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук 1, no. 5 (December 6, 2016): 175–80. http://dx.doi.org/10.12737/23420.
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Currently worldwide chemical burns of the esophagus rank first among all diseases of the esophagus in children and second in adults. Because of commonly accepted algorithms of rendering of medical aid in case of chemical burns of the esophagus in the prehospital and hospital stages (washing of the esophagus and the stomach, adequate anesthesia, corticosteroid, antibiotic therapy, the group of antacids and symptomatic treatment), the choice of drug and method of local impact on the surface of chemical burn of the esophagus remain an urgent problem. The lack of standardized approach in treatment of local changes in chemical burns of the esophagus, severe and unsatisfactory results of using medication algorithms inspire a search for alternative methods of treatment and drug development. Herbal remedies are comparable in effectiveness, but also have the combined multivalent effect on the entire body, causing minimum of side effects. Basing on the literature review, we have come to a conclusion that the most balanced composition of biologically active substances and a positive influence on the basic pathogenesis of esophageal chemical burns has Calendula officinalis. Features and scope of Calendula officinalis are not fully understood. The creation of a multidrug for the local treatment chemical burns of the esophagus based on this herb proves to be very promising.
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Aranha, Luana Cabrino, Nilton César Aranha, André Brandalise, and Nelson Ary Brandalise. "Laparoscopic treatment of giant circumferential leiomyoma of the distal esophagus." Revista de Medicina 99, no. 1 (February 3, 2020): 84–87. http://dx.doi.org/10.11606/issn.1679-9836.v99i1p84-87.
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Introduction: Leiomyomas are rare esophagus tumors, with 0.4-1% incidence of all esophagus tumors. Only 5% grow to the point of being called giant tumors, measuring more than 10cm. Symptoms usually begin on tumors bigger than 5cm. Objective: Reporting a new therapeutic course of action to giant leiomyomas of distal esophagus. Case Report: VCA, female, 38 years old, presented retrosternal oppression for 4 months. Having realized a computed tomography on another service which demonstrated a mass suggestive of leiomyoma. On the endoscopy exam, performed for heartburn complaint and mild dysphagia, was determined a hiatal hernia of 2cm and mild gastritis. Patient submitted to complete excision of tumor without mucosal lesion and reconstruction of the external muscular wall, by the video laparoscopic method. Hiatoplasty and partial esophagogastrofundoplication were associated. The anatomic pathological examination confirmed leiomyoma, with 10x5x2cm. Patient evolved clinically without the appearance of the heartburn or dysphagia. With contrast examination of the esophagus after 6 months and endoscopy and tomography the following 4 years, all normal. The classic treatment of giant leiomyomas, includes thoracotomy with esophagectomy. Considering that in 80% of the cases it is found in the middle and lower thirds of the esophagus, the videolaparoscopic approach by transhiatal route becomes possible. The reconstruction of the external muscular layer is important to prevent a possible prolapse of the mucosa. Also, the realization of the fundoplication in addition to avoiding the gastroesophageal reflux, allows the suture area of the esophageal muscular wall to be covered, increasing the safety in the treatment. In services with experience in the surgical treatment of diseases of the gastric esophagus transition through the videolaparoscopic method, it is possible to perform with adequate safety the surgical treatment of the tumor lesions of the distal esophagus. The method provides greater postoperative comfort and prompt clinical surgical recovery.
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Galimov, O. V., V. O. Khanov, M. R. Bakirov, R. R. Saifullin, and D. O. Galimov. "WAYS TO IMPROVE RESULTS OF ENDOSURGICAL TREATMENT OF ACHALASIA." Surgical practice, no. 2 (September 10, 2020): 5–9. http://dx.doi.org/10.38181/2223-2427-2020-2-5-9.
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Aim. To improve the method of Heller cardiomyotomy for best immediate and long-term results of treatment of esophageal achalasia.Materials and methods. Analyzing the results of surgical treatment of 280 patients with esophageal achalasia who were treated in the Department of Surgical Diseases and New Technologies of the Bashkir State Medical University (Ufa) and the Department of Surgery and Stomach of the Republican Clinical Oncology Center (Kazan) for a period from 2000 to 2019. We conducted a cohort retrospective study in 2 groups (laparoscopic esophagocardiomyotomy according to Heller, supplemented by anterior modified hemifundoplication according to Dor (n = 74) and traditional laparoscopic interventions (n = 206).Results. The authors have developed an original method of laparoscopic esophagocardiomyotomy, including the use of devices that facilitate the mobilization of cardia and the formation of fundoplication cuffs. Patients were examined by performing esophagogastroduodenoscopy, contrast X-ray scopy of the esophagus and stomach, esophagomanometry, pH-measurement in distal part of esophagus. Long-term results of up to 2 years were tracked. Surgically treated patients were tested by special application forms. Received results showed the restoration of quality of life in most of the subjects.Conclusion The developed technique of laparoscopic esophagocardiomyotomy, including the use of intra-esophageal transillumination and a device for measuring the esophagus, prevents damage to the esophagus wall and postoperative complications associated with insufficient or excessive narrowing of the esophagus. Of the 74 patients, 66 (89.2 %) rated the result as excellent and good, 6 (8.1 %) as satisfactory, and 2 (2.7 %) as unsatisfactory.
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Parshin, Vladimir, Sergey Osminin, Roman Komarov, Sergey Vetshev, Yuriy Strakhov, and Ivan Ivashov. "Rare diseases of esophagus: Surgical treatment of cysts in adults. Case report." International Journal of Surgery Case Reports 81 (April 2021): 105732. http://dx.doi.org/10.1016/j.ijscr.2021.105732.
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Aranha, Luana Cabrino, Nilton César Aranha, Nelson Ary Brandalise, and André Brandalise. "Laparoscopic treatment of giant circumferential leiomyoma of the distal esophagus." Revista de Medicina 98, Suppl (October 4, 2019): 14. http://dx.doi.org/10.11606/issn.1679-9836.v98isupplp14-14.
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Introduction: Leiomyomas are rare esophagus tumors, with 0.4-1% incidence of all esophagus tumors, being more frequent in medium and distal portions1. Only 5% grow to the point of being called giant tumors, measuring more than 10cm2. Symptoms usually begin on tumors equal to or bigger than 5cm. Objectives: The following case objectifies reporting a new therapeutic course of action to giant leiomyomas of distal esophagus. Case Report: VCA, female, 38 years old, presented retrosternal oppression for 4 months. Having realized a computed tomography (CT) on another service 5 days ago which demonstrated a tumor injury on the distal esophagus and suggestive of leiomyoma. Patient was submitted through endoscopy exam 4 months ago, for complaint of heartburn and mild dysphagia. It was determined a hiatal hernia of 2cm and mild gastritis. Patient was submitted to complete excision of tumor without mucosal lesion and reconstruction of the external muscular wall, by the video laparoscopic method. Hiatoplasty and partial esophagogastrogemorplication were associated. The anatomic pathological examination confirmed the leiomyoma, with 10x5x2cm. Patient evolved clinically in the long term without the appearance of the heartburn or dysphagia. The patient underwent contrast examination of the esophagus after 6 months and endoscopy and tomography for the following 4 years, all normal. The classic treatment of giant leiomyomas larger than 10cm, includes thoracotomy with esophagectomy. Considering that in 80% of the cases it is found in the middle and lower thirds of the esophagus, the videolaparoscopic approach by transhiatal route becomes possible3. The reconstruction of the external muscular layer is important to prevent a possible prolapse of the mucosa1. Also, the realization of the fundoplication in addition to avoiding the gastroesophageal reflux, allows the suture area of the esophageal muscular wall to be covered, increasing the safety in the treatment4. In services with experience in the surgical treatment of diseases of the gastric esophagus transition through the videolaparoscopic method, it is possible to perform with adequate safety the surgical treatment of the tumor lesions of the distal esophagus. The method provides the patient with greater postoperative comfort and prompt clinical surgical recovery.
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Korolevska, A. Yu, S. Yu Bityak, V. V. Zhidetskyi, A. B. Starikova, and Ye A. Novikov. "CAUSES OF ADVERSE SURGERY EFFECTS IN TREATMENT OF PATIENTS WITH ESOPHAGUS STENOTIC DISEASES." International Medical Journal, no. 3 (September 16, 2020): 23–27. http://dx.doi.org/10.37436/2308-5274-2020-3-5.
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Esophageal stenosis requires a responsible approach to the choice of rational treatment tactics. Intraoperatively, bleeding, interponate necrosis, complications associated with the wrong choice of the path of the interponate imposition to the neck, damage to the nutrient vessel (the arcade rupture), pleural leaves during the formation of the thoracic tunnel, n. vagus and its branches, pneumothorax, hemothorax, uncontrolled mediastinal bleeding, the need for drainage of the pleural cavity due to injury to the latter, iatrogenic splenectomy, membranous tracheal tear. Post−surgery complications are developed at different times after esophagoplasty. Most often, early postoperative complications occur because of the wound: bleeding and failure of the sutures of the anastomosis line. Complications resulted from the respiratory system are as follows: tracheobronchitis, pleurisy, "congestive", nosocomial pneumonia and atelectasis, pleural empyema. In the remote post−surgery period, the patients may experience: stenosis of the esophageal (or pharyngeal) anastomosis, adhesions, fistulas, reflux, peptic ulcers of the esophagus, pain, inflections and excess loops, complications associated with mechanical trauma of implant, scar−altered cancer esophagus, polyposis of the colon, various disorders associated with primary trauma, nonspecific complications. Damage to the recurrent nerve in patients causes constant hoarseness and difficult swallowing. Occasionally there are cardiac arrhythmias in the form of atrial fibrillation, "sympathetic" pleurisy, reflux, post−vagotomy symptom and dumping syndrome, delayed gastric emptying due to insufficient dilated pyloromyotomy in the patients with a combination of stenosis of the esophageal lumen and esophageal lumen hernia. Key words: esophageal stenosis, esophageal anastomosis, postoperative complications.
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Tyselskyi, V. V., B. G. Bondarchuk, V. A. Hordovskyi, and A. B. Kebkalo. "Application of biological welding as a method of treatment of esophageal metaplasia." Klinicheskaia khirurgiia 87, no. 5-6 (July 24, 2020): 9–12. http://dx.doi.org/10.26779/2522-1396.2020.5-6.09.
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Objective. To estimate a high-frequency welding of the living tissues as a variant of treatment for the Barrett’s esophagus.
Materials and metods. Retrospective analysis of the treatment results was conducted in 73 patients, suffering Barrett’s esophagus, in 36 of whom the argon-plasm coagulation was performed (Group I), while in 37 (Group II) - a high frequency welding of living tissues. Into the investigation the patients with a short-segment Barrett’s esophagus C2-3M3-4 (the Prague Classification, 2004 yr) and a high-grade dysplasia without a nodule development (VI World Congress of International Society for Diseases of the Esophagus (ISDE) were included.
Results. In patients of Group I a severe esophageal edema have occurred in accordance to endoscopic ultrasonography data. In this Group in 5 (13.89%) patients after performance of the argon-plasm coagulation esophageal stenosis was observed, corrected by application of the balloon dilation. In 8 (22.22%) patients of this Group the disease recurrence have occurred, necessitating performance of additional séance of the argon-plasm coagulation. In patients of Group II the above mentioned inflammatory signs were less pronounced, and mucosal regeneration have proceeded more rapidly, than in patients of Group I - during 53 and 115 days, accordingly. The disease recurrence was noted in 2 (5.41%) patients of Group II only.
Conclusion. High-frequency welding of living tissues constitute a safe and effective method of treatment in patients, having esophageal metaplasia.
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Takahashi, Kozue, Yusuke Taniyama, Tadashi Sakurai, Takahiro Heishi, Chiaki Sato, Kai Takaya, Hiroshi Okamoto, Shota Maruyama, Michiaki Unno, and Takashi Kamei. "PS01.085: TREATMENT STRATEGY FOR AORTO-ESOPHAGEAL FISTULA." Diseases of the Esophagus 31, Supplement_1 (September 1, 2018): 73. http://dx.doi.org/10.1093/dote/doy089.ps01.085.
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Abstract Background Aorto-esophageal fistula (AEF) is relatively rare, but life-threatening condition. AEF is usually caused in the patients with thoracic aortic diseases, such as aneurysms, or after thoracic aortic surgery. We present our surgical strategy for AEF. Methods From May 2004 to November 2017, 12 patients with AEF were treated at our hospital. The age ranges from 44 to 83 years, and the number of male/female was 9/3. Five patients had previous thoracic endovascular aortic repair (TEVER) in the descending aorta, four patients had descending or total arch replacement. Two patients caused by rupture of thoracic aortic aneurysm, and one patient had penetration of esophagus caused by aspiration of Press Through Package. As the first procedures for surgical treatment, we perform TEVAR in order to prevent the fatal hemorrhage from aortic pseudoaneurysm. At the same day, removal of esophagus with debridement of adjacent infected tissues is performed by open thoracic procedure. After a few days, excision of the infected graft or the aorta followed by new graft replacement with omental flap installation is performed. Four patients used homograft and four patients used rifampicin-soaked graft. After the patient's general condition improve, we plan to perform open surgery for reconstruction of esophagus. Results A 3-year survival rate was 50%, and perioperative mortality was 25%. Hospital mortality was noted in 3 patients due to sepsis, brainstem infarction and pulmonary hemorrhage (6–117 days after the first surgery). Late death occurred in 4 patients (n = 2: ileus, n = 1: carcinoma, n = 1: pneumonia). Eight patients could undergo esophagus reconstruction, by colon graft in 4 patients, a pedicled jejunum and a gastric tube in 2 patients, respectively. The duration from esophageal resection to reconstruction was 1–11 months. Conclusion Because AEF usually accompanied with hemodynamic instability, immediate surgical intervention is regarded as the only effective treatment. Corporation between gastrointestinal surgeons and cardiovascular surgeons is necessary to achieve this treatment. We share our experiences of AEF treatment and discuss surgical strategy. Disclosure All authors have declared no conflicts of interest.
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Campos, Sara, Jan-Werner Poley, Lydi van Driel, and Marco J. Bruno. "The role of EUS in diagnosis and treatment of liver disorders." Endoscopy International Open 07, no. 10 (October 2019): E1262—E1275. http://dx.doi.org/10.1055/a-0958-2183.
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Abstract Background and aim Transabdominal ultrasound (US), computed tomographic scanning (CT) and magnetic resonance imaging (MRI) are established diagnostic tools for liver diseases. Percutaneous transhepatic cholangiography is used to perform hepatic interventional procedures including biopsy, biliary drainage procedures, and radiofrequency ablation. Despite their widespread use, these techniques have limitations. Endoscopic ultrasound (EUS), a tool that has proven useful for evaluating the mediastinum, esophagus, stomach, pancreas, and biliary tract, has an expanding role in the field of hepatology complementing the traditional investigational modalities. This review aimed to assess the current scientific evidence regarding diagnostic and therapeutic applications of EUS for hepatic diseases.
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Mogilevets, Eduard. "Treatment and prevention of bleeding from varicose veins of the esophagus." Science and Innovations 1, no. 215 (January 2021): 80–83. http://dx.doi.org/10.29235/1818-9857-2021-1-80-83.
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Liver cirrhosis is the result of various chronic liver diseases. Portal hypertension is a serious complication of cirrhosis. Its consequences, in turn, along with other complications are gastroesophageal varicose bleeding, which cause high mortality rates. The article contains analysis of the results of laparoscopic esophagogastric devascularization without esophageal transsection and splenectomy in a patient with liver cirrhosis portal hypertension and recurrent bleeding from varicose veins of the esophagus. First successful surgery according to this method was introduced in the Grodno Municipal Clinical Hospital No. 4 in November 2011. Immediate and long-term results show a rather high efficiency of using this operation in the treatment and prevention of bleeding from varicose veins of the esophagus with cirrhosis. It is advisable to conduct further studies of the effectiveness of using this operation, despite the encouraging results of the use of this modification of laparoscopic esophagogastric devascularization.
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Evdokimov, V. I., P. P. Sivashchenko, S. G. Grigoriev, and V. V. Ivanov. "Indicators of dismissal of military personnel of the Armed Forces of the Russian Federation for health reasons in 2003-2018." Bulletin of the Russian Military Medical Academy 22, no. 2 (June 15, 2020): 164–70. http://dx.doi.org/10.17816/brmma50067.
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The dynamics and structure of the dismissal of officers and military personnel of the Russian Armed Forces for health reasons in 2003-2018 are analyzed. It was established that the average annual dismissal rate for officers was7,981,10, contract servicemen 3,920,32, conscripted military personnel 17,571,19, female military personnel9,141,37. The polynomial trend of dismissal of all categories of military personnel showed decreasing trends. The level ofdismissal of military personnel by the leading classes of diseases and nosologies (groups in chapters) is presented. The indicatorsof the causes of dismissal were correlated with the chapters and nosologies of the International Statistical Classification ofDiseases and Health Problems, 10th revision. The 1st rank of dismissals for health reasons for officers was taken by indicatorsof diseases characterized by high blood pressure (I10-I15), the 2nd - coronary heart disease (I20-I25), the 3rd - diseases ofthe esophagus, stomach, and duodenum (K20-K31); contracted military personnel have diseases of the esophagus, stomachand duodenum (K20-K31), diseases characterized by high blood pressure (I10-I15), neurotic, stress-related, and somatoformdisorders (F40-F48); in conscripted servicemen - neurotic, connected stress, and somatoform disorders (F40-F48), diseasesof the esophagus, stomach, and duodenum (K20-K31), behavioral disorders in adulthood (F60-F69); among female militarypersonnel obesity and other types of excess nutrition (E65-E68), diseases characterized by high blood pressure (I10-I15),inflammatory diseases of the female pelvic organs (N70-N77). Prevention, timely treatment and rehabilitation of leadingnosologies will contribute to improving the health and professional longevity of the Russian Armed Forces.
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Inayat, Faisal, Simcha Weissman, Adnan Malik, Badria Munir, and Shahzad Iqbal. "Endoscopic Submucosal Tunnel Dissection as a Novel Therapeutic Technique in Patients With Barrett’s Esophagus." Journal of Investigative Medicine High Impact Case Reports 8 (January 2020): 232470962094131. http://dx.doi.org/10.1177/2324709620941318.
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With the ameliorated resectability prowess of endoscopic techniques, a myriad of diseases previously treated by major ablative surgeries are now endoscopically curable. Endoscopic submucosal tunnel dissection (ESTD) is a relatively new technique that has diversified endoscopic application. Although ESTD has frequently been used for the resection of esophageal neoplastic lesions, the clinical evidence pertaining to its efficacy in the treatment of circumferential Barrett’s esophagus remains sparse. In this study, we evaluated ESTD as a potential therapeutic technique in patients with Barrett’s esophagus-related high-grade dysplasia. The tunneling strategy helped achieve complete en bloc resection at an increased dissection speed, without any procedural complications. This article illustrates that ESTD can be a feasible, safe, and effective treatment for dysplastic Barrett’s esophagus. Future research should aim to stratify the potential risks and complications associated with this optimization of endoscopic submucosal dissection in patients with superficial esophageal lesions.
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Muslimov, R. Sh, Sh N. Danielyan, I. E. Popova, and N. R. Chernaya. "Aotric esophageal fistula: etiopathogenesis and diagnostics (review of literature)." Grekov's Bulletin of Surgery 179, no. 6 (April 2, 2021): 89–93. http://dx.doi.org/10.24884/0042-4625-2020-179-6-89-93.
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Aortic esophageal fistula (AEF) is a rare but extremely life-threatening condition requiring immediate surgical treatment. The mortality rate among such patients may exceed 60 %, including after surgical treatment. Etiological and pathogenetic mechanisms of AEF are complex and various, but in most cases, they are associated with chronic aortic diseases. The second group of etiological factors of AEF includes trauma of esophagus wall by foreign bodies, malignant neoplasms of the esophagus or mediastinum. AEF may also occur as a result of surgical interventions on the aorta and esophagus. The difficulties of early diagnosis are primarily associated with non-specific clinical manifestations of AEF and the lack of unified protocol for the examination of patients with the first-time upper gastrointestinal tract bleeding. The described reasons in some cases can lead to an inaccurate diagnosis, which entails a loss of time. Among the instrumental diagnostic methods, the most informative is the combination of esophagogastroduodenoscopy and computed tomography of the chest with intravenous contrast enhancement. Each of these methods has its advantages and disadvantages, and allows to identify a number of direct and indirect signs of pathological communication between the aorta and the esophagus.
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Medina, Benjamin, and Daniela Molena. "Reflux, Barrett’s Esophagus, and Esophageal Adenocarcinoma After Bariatric Surgery." Foregut: The Journal of the American Foregut Society 1, no. 4 (December 2021): 393–400. http://dx.doi.org/10.1177/26345161211068367.
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We present the case of a patient who developed esophageal adenocarcinoma after a previous laparoscopic sleeve gastrectomy. Bariatric surgery has emerged as the most effective treatment option for weight loss and obesity-related diseases; however, sleeve gastrectomy promotes gastroesophageal reflux and leads to Barrett’s esophagus in a substantial portion of patients. The natural history of Barrett’s esophagus in these patients is unknown, and active surveillance is recommended until the incidence of dysplasia and adenocarcinoma in this population is clarified. Management options for these patients include conversion to Roux-en-Y gastric bypass. Although esophagectomy in patients who have previously undergone sleeve gastrectomy may require an alternative conduit, the remnant stomach can be used in carefully selected patients. Here, we review the different weight loss procedures, their effect on gastroesophageal reflux disease and Barrett’s esophagus, and the treatment options for patients with esophageal cancer after sleeve gastrectomy. We report the use of preoperative coil embolization as a means of vascular preconditioning before successful use of a gastric conduit.
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Kolodzeyskiy, Ya A., V. I. Shishko, А. A. Karpovich, Yu Ya Shelkovich, and T. N. Yakubchik. "СУТОЧНАЯ МНОГОКАНАЛЬНАЯ РН-ИМПЕДАНСОМЕТРИЯ ПИЩЕВОДА В ДИАГНОСТИКЕ ГАСТРОЭЗОФАГЕАЛЬНОЙ РЕФЛЮКСНОЙ БОЛЕЗНИ (КЛИНИЧЕСКИЕ СЛУЧАИ)." Hepatology and Gastroenterology 5, no. 2 (December 25, 2021): 197–204. http://dx.doi.org/10.25298/2616-5546-2021-5-2-197-204.
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Background. Gastroesophageal reflux disease (GERD) is an urgent problem of modern gastroenterology as well as the most common pathology of the upper gastrointestinal tract; it is a chronic disease that significantly reduces the patient's quality of life, increases the risk of developing Barrett's esophagus and esophageal adenocarcinoma. Objective. To assess the potentials of multichannel intraluminal pH impedance monitoring in the diagnosis of esophageal diseases. Material and methods. In 3 patients with clinical and endoscopic signs of GERD esophageal multichannel intraluminal pH-impedance monitoring was performed using the diagnostic equipment Digitrapper pH-Z from Given Imaging (USA). Results. 24-hour esophageal pH monitoring enabled to verify the diagnosis of GERD, to reveal a hypersensitive esophagus and manifestations of nocturnal acid breakthrough. Conclusions. Multichannel intraluminal pH-impedance monitoring is the "gold standard" for the diagnosis of esophageal diseases; it significantly expands opportunities of gastroenterologists in the treatment of GERD.
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Shah, Manish A. "Will Disease Heterogeneity Help Define Treatment Paradigms for Gastroesophageal Adenocarcinoma? A Global Perspective." American Society of Clinical Oncology Educational Book, no. 32 (June 2012): 256–59. http://dx.doi.org/10.14694/edbook_am.2012.32.142.
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Overview: Cancers of the upper gastrointestinal (GI) tract form a heterogeneous group of diseases for which treatment paradigms for localized disease continue to emerge. Recently, several phase III studies in esophagus and gastric cancer that have attempted to define new standards of care have been reported. However, controversy still persists and treatment algorithms often depend on individual preference, patient referral patterns, and treatment biases. In the current era of improving quality control and standardization of care, such variations in practice present a substantial challenge for both patients and physicians. In this article, I will highlight differences in disease biology for upper GI diseases, and in particular, gastric cancer.
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Tyselskyi, Volodymyr, Vitaliy Poylin, and Andrey Kebkalo. "Biological welding – novel technique in the treatment of esophageal metaplasia." Polish Journal of Surgery 92, no. 5 (April 19, 2020): 1–5. http://dx.doi.org/10.5604/01.3001.0014.1176.
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<b>Introduction:</b> Biological welding – controlled action of high frequency current on living tissues, which leads to their structural changes and weld formation – connection with unique biological properties (strength, high elasticity, insensitivity to microbial infection, stimulating effect on the regeneration process, speed and quality which surpasses the normal uncomplicated healing) [22]. This method is used in various fields of surgery, but at the moment there is no data on its use in case of esophageal cylindrocellular (intestinal) metaplasia (further esophageal metaplasia or Barrett’s esophagus). <br><b>Objective:</b> The goal of this study is to evaluate biologic welding as a treatment option for patients with Barrett’s esophagus. <br><b>Materials and methods:</b> Single-center retrospective review of patients with short-segment Barrett’s esophagus and metaplasia were treated by argon plasma coagulation (APC) or Paton’s welding. This was followed by Nissen fundoplication. Primary outcome of this study was mucosal healing with morphological confirmation of the absence of metaplasia. The groups included patients with a short segment of the esophagus Barrett’s C2-3M3-4 (Prague Classification 2004) and high dysplasia without nodule formation in combination with hiatal hernia (VI World Congress of the International Society for Esophageal Diseases; ISED) [23–25]). <br><b>Results:</b> A total of 49 patients were included in the study with 25 patients treated by APC laser and 24 by biowelding. Four patients (16.0%) in the APC group developed stenosis and 5 patients (20.0%) developed recurrence compared to none in the biowelding group. Patients in the biowelding group had a significantly faster rate of mucosal healing leading to faster progression to Nissen fundoplication (at average 53 days) compared to APC laser group (surgery at 115 days). <br><b>Conclusions:</b> Biological welding of Paton’s is a safe and effective treatment option for patients with esophageal metaplasia.
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Yeh, Pai-Jui, Ren-Chin Wu, Cheng-Tang Chiu, Ming-Wei Lai, Chien-Ming Chen, Yu-Bin Pan, Ming-Yao Su, Chia-Jung Kuo, Wey-Ran Lin, and Puo-Hsien Le. "Cytomegalovirus Diseases of the Gastrointestinal Tract." Viruses 14, no. 2 (February 8, 2022): 352. http://dx.doi.org/10.3390/v14020352.
Full textAbstract:
Cytomegalovirus (CMV) infection of the gastrointestinal (GI) tract can be fatal. However, very few studies have provided comprehensive analyses and specified the differences in symptoms observed in different parts of the GI tract. This study aimed to comprehensively analyze clinical manifestations and management of GI CMV disease. This retrospective cohort study enrolled the patients who had CMV diseases of the GI tract proved by CMV immunohistochemistry stain from the pathology database in a 4000-bed tertiary medical center between January 2000 and May 2021. The patient characteristics, clinical manifestations, endoscopic features, treatments, outcomes, and prognostic factors were analyzed. A total of 356 patients were enrolled, including 46 infected in the esophagus, 76 in the stomach, 30 in the small intestine, and 204 in the colon. In total, 49.4% patients were immunocompromised. The overall in-hospital mortality rate was 20.8%: CMV enteritis had the highest rate (23.3%). Sixty percent of patients received antiviral treatment and 16% were administered both intravenous and oral anti-viral drugs (Combo therapy, minimal and mean treatment duration were 14 and 39.9 ± 25 days). Prognostic factors of in-hospital mortality included age, immune status, albumin level, platelet count, GI bleeding, time-to-diagnosis, and Combo therapy. In the survival analysis, immunocompetent patients receiving Combo therapy had the best survival curve, and immunocompromised patients receiving non-Combo therapy had the worst survival curve. Combo therapy ≥14 days resulted in a better outcome for both immunocompromised and immunocompetent patients. In conclusion, CMV GI diseases affect both immunocompromised and immunocompetent hosts, and a complete treatment course should be considered for patients with poor prognostic factors.
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Wu, Ze-Yu, Li-Xuan Sang, and Bing Chang. "Cronkhite–Canada syndrome: from clinical features to treatment." Gastroenterology Report 8, no. 5 (October 1, 2020): 333–42. http://dx.doi.org/10.1093/gastro/goaa058.
Full textAbstract:
Abstract Cronkhite–Canada syndrome (CCS) is a rare acquired polyposis with unknown etiology. To date, >500 cases have been reported worldwide. CCS is typically characterized by gastrointestinal symptoms, such as diarrhea and skin changes (e.g. alopecia, pigmentation, and nail atrophy). Endoscopic features include diffuse polyps throughout the entire gastrointestinal tract, except for the esophagus. Pathological types of polyps in CCS mainly include inflammatory, hyperplastic, hamartomatous, and adenomatous polyps. CCS can be complicated by many diseases and has a canceration tendency with a high mortality rate. Moreover, there is no uniform standard treatment for CCS. A review of the reported cases of CCS is presented herein, with the goal of improving our understanding of this disease.
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Chernousov, A. F., T. V. Khorobrykh, F. P. Vetshev, L. V. Romasenko, V. A. Dulova, and S. V. Osminin. "Complex treatment of patients with achalasia of cardia and cardiospasm subject to psychosomatic disorders." Clinical Medicine (Russian Journal) 96, no. 5 (October 12, 2018): 419–26. http://dx.doi.org/10.18821/0023-2149-2018-96-5-419-426.
Full textAbstract:
Achalasia of cardia and cardiospasm are neuromuscular diseases characterized by functional disorders of the permeability of the esophageal-gastric junction, their prevalence is up to 22% of all diseases of the esophagus. The article presents a series of clinical studies of 114 patients with achalasia of cardia and cardiospasm since 2006. A modified algorithm for the examination and treatment ofpatients with different stages of the disease is presented. The balloon cardiodilation, as the main method of treatment, was carried out by 76 patients. Surgical treatment was performed in 36 patients: 17 patients with stage III performed esophagocardiomyotomy with incomplete fundoplication in the modification of A.F. Chernousov, 19 - with the IV stage transhiatal extirpation of the esophagus with gastroplasty was performed. A group of 26 patients with psychosomatic disorders was selected, who, in addition to traditional surgical treatment, underwent psychotropic therapy. Good immediate and long-term results of complex treatment were obtained. Substantially faster relief of symptoms of dysphagia and other complaintsfrom the gastrointestinal tract was noted, a more persistent and prolonged effect of dilation sessions and a significant improvement in the quality of life compared with patients who did not receive psychotropic drugs. In this group of patients, we did not observe any recurrence of the disease after the dilatation sessions. The control examination (endoscopic and X-ray examination of the upper gastrointestinal tract, manometry) revealed no signs of dysphagia or gastroesophageal reflux in any patient, including among the operated.
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Rybina, O. V., V. T. Sakhin, A. V. Gubkin, E. V. Kryukov, and O. A. Rukavitsyn. "Features of pathogenesis and ways of anemia correction in patients with diseases of the upper gastrointestinal tract." Clinical Medicine (Russian Journal) 100, no. 2-3 (June 25, 2022): 126–32. http://dx.doi.org/10.30629/0023-2149-2022-100-2-3-126-132.
Full textAbstract:
Anemia is a frequently diagnosed complication in patients with various diseases of the esophagus and stomach, which negatively affects the quality of life and aggravates the course of the prior disease. There are three main mechanisms for reducing hemoglobin in the pathology of the upper gastrointestinal tract: bleeding, malabsorption, chronic inflammation. A combination of pathogenetic factors often leads to anemia associated with a deficiency of both iron and vitamin B complex. Anemia of chronic diseases is less common.Material and methods. 38 people with diseases of the esophagus and stomach were examined: 20 women and18 men. The average age was 70 years old. All patients were divided into groups according to the diagnosed variant of anemia: iron deficiency anemia (IDA), anemia of chronic diseases (ACD) and a combination of IDA and ACD, as well as by the type of therapy performed (therapy with iron preparations, B vitamins and treatment of the prior disease).Results. A comparative analysis of the hematopoietic lineage indices before and after the treatment was performed. A clinically significant increase in hemoglobin, erythrocytes and erythrocyte indices was observed in patients with IDA who received parenteral therapy with iron preparations, as well as combined treatment with iron preparations and B vitamins. In the ACD and ACD + IDA groups, there were no significant changes in the parameters of the hematopoietic lineage in any of the therapy variants.Conclusion. The effect of the treatment was found only in patients with IDA who received parenteral therapy with iron preparations. The rest treatment options did not show a positive effect on the dynamics of blood indices in any of the groups. Perhaps a longer follow-up and an increase in the sample of patients will allow creating an effective individualized algorithm for anemia therapy.
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AMANOV, Т. "SUTURING TECHNIQUE FOR ESOPHAGOGASTRIC AND GASTROENTEROANASTOMOSIS DURING OPERATIONS ON THE ESOPHAGUS AND STOMACH." Oncologia i radiologia Kazakhstana 64, no. 2 (June 30, 2022): 24–27. http://dx.doi.org/10.52532/2663-4864-2022-2-64-24-27.
Full textAbstract:
Relevance: Esophageal cancer is in 4th place, and gastric cancer is in 3rd place in terms of cancer incidence in the West Kazakhstan region
(WKR). In 2019-2021, an average of 80-120 patients had identified annually, of which 40-50 patients underwent surgical treatment.
The study aimed to evaluate the effectiveness of the proposed improved method of suturing the anastomosis and enhancing the results of surgery by reducing postoperative complications in the form of anastomosis failure and reducing the time of the intra-operative period.
Methods: In 2019-2021, 150 operations on the esophagus and stomach were performed in the Regional Oncological Dispensary of the West
Kazakhstan Region (Uralsk, Kazakhstan) in the amount of Lewis operation – 76, Garlock operation – 29, extended gastrectomy – 45.
According to the method of M.I. Davydov, the standard technique of suturing includes four stages and involves the imposition of 16 stitches.
In the proposed version, an improved technique consisting of 3 steps is used without forming the second row of anterior lip anastomosis sutures.
The results were evaluated according to the following criteria: a) the number of cases of anastomosis failure compared to the standard procedure; b) the duration of the intraoperative period.
Results: Using an improved technique for applying esophagogastric and esophago-intestinal anastomosis has reduced the number of postoperative complications. So, from 2019-2021, postoperative complications decreased from 8.1% to 3.9%.
Conclusion: The effectiveness and practicality of the proposed technique of applying esophagogastric and esophago-intestinal anastomosis
during operations in patients with diseases of the esophagus and stomach have been proven.
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Moroz, E. V., T. V. Popkova, and A. E. Moroz. "Manifestations of the gastrointestinal tract in systemic rheumatic diseases: A narrative review." Rheumatology Science and Practice 60, no. 6 (December 25, 2022): 578–86. http://dx.doi.org/10.47360/1995-4484-2022-578-586.
Full textAbstract:
Gastrointestinal disorders are important place among the visceral manifestations of systemic autoimmune and immunoinflammatory rheumatic diseases (RD). Pathology of the esophagus, stomach, small and large intestine can vary from moderate functional disorders to the development of severe chronic inflammation with metaplasia and dysplasia of the mucous membrane, the formation of multiple erosions, hemorrhages and deep ulcers. Complications of gastrointestinal pathology in RD, such as bleeding, perforations and strictures, can cause death. This review examines the main clinical manifestations, possibilities of diagnosis and treatment of gastrointestinal lesions in systemic scleroderma, idiopathic inflammatory myopathies, systemic vasculitis, Sjogren’s syndrome and disease, as well as systemic lupus erythematosus.
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Amanov, Т. "SUTURING TECHNIQUE FOR ESOPHAGOGASTRIC AND GASTROENTEROANASTOMOSIS DURING OPERATIONS ON THE ESOPHAGUS AND STOMACH." Oncologia i radiologia Kazakhstana 64, no. 2 (June 30, 2022): 24–27. http://dx.doi.org/10.52532/2521-6414-2022-2-64-24-27.
Full textAbstract:
Relevance: Esophageal cancer is in 4th place, and gastric cancer is in 3rd place in terms of cancer incidence in the West Kazakhstan region
(WKR). In 2019-2021, an average of 80-120 patients had identified annually, of which 40-50 patients underwent surgical treatment.
The study aimed to evaluate the effectiveness of the proposed improved method of suturing the anastomosis and enhancing the results of surgery by reducing postoperative complications in the form of anastomosis failure and reducing the time of the intra-operative period.
Methods: In 2019-2021, 150 operations on the esophagus and stomach were performed in the Regional Oncological Dispensary of the West
Kazakhstan Region (Uralsk, Kazakhstan) in the amount of Lewis operation – 76, Garlock operation – 29, extended gastrectomy – 45.
According to the method of M.I. Davydov, the standard technique of suturing includes four stages and involves the imposition of 16 stitches.
In the proposed version, an improved technique consisting of 3 steps is used without forming the second row of anterior lip anastomosis sutures.
The results were evaluated according to the following criteria: a) the number of cases of anastomosis failure compared to the standard procedure; b) the duration of the intraoperative period.
Results: Using an improved technique for applying esophagogastric and esophago-intestinal anastomosis has reduced the number of postoperative complications. So, from 2019-2021, postoperative complications decreased from 8.1% to 3.9%.
Conclusion: The effectiveness and practicality of the proposed technique of applying esophagogastric and esophago-intestinal anastomosis
during operations in patients with diseases of the esophagus and stomach have been proven.
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Trukhmanov, A. S., and N. Yu Ivashkina. "The clinical significance of disorders of the motor function of the esophagus, stomach and duodenum." Terapevticheskii arkhiv 91, no. 8 (August 15, 2019): 127–34. http://dx.doi.org/10.26442/00403660.2019.08.000390.
Full textAbstract:
The purpose of the review is to determine the relationship between the clinical symptoms of diseases and disorders of the motor function of the esophagus, stomach and duodenal bulb, to present modern methods of their diagnosis and pathogenetic principles of treatment of diseases. Depending on the pathogenesis, it is possible to distinguish secondary motility disorders resulting from organic lesions, and primary (functional) changes. The emergence of clinical symptoms is associated with impaired motor - evacuation function of the digestive tract, which can be divided into two large groups: changes in the peristaltic activity of the organ wall and the work of the sphincter apparatus. The basis of the regulation of motility of the esophagus, stomach and duodenum is the interaction of nervous and humoral factors, the central processing of impulses is carried out in the cerebral cortex. In case of violation of the coordinated action of inhibitory and excitatory regulation systems, pathological contractile activity occurs, which manifests itself as hypo - or hyper - motor dyskinesia. X-ray, ultrasound, high resolution manometry of the esophagus, pH-meter, scintigraphy, computed tomography, antroduodenal manometry and a number of others are used to diagnose disorders of the motor function of the digestive tract, which can determine the mechanism of the development of symptoms and prescribe pathogenetic treatment to the patient. Thus, the occurrence of clinical symptoms is associated with changes in the motor - evacuation function of the digestive tract due to a violation of the coordinating action of inhibitory and excitatory factors. The use of modern diagnostic methods for the study of motor function makes it possible to determine the mechanism for the development of clinical symptoms, which allows the patient to prescribe an effective pathogenetic treatment.
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Bilello, Joshua, and Ikenna Okereke. "Impact of Environmental and Pharmacologic Changes on the Upper Gastrointestinal Microbiome." Biomedicines 9, no. 6 (May 29, 2021): 617. http://dx.doi.org/10.3390/biomedicines9060617.
Full textAbstract:
Diseases of the upper gastrointestinal tract have become more prevalent over time. Mechanisms of disease formation are still only partially understood. Recent literature has shown that the surrounding microbiome affects the propensity for disease formation in various parts of the upper gastrointestinal tract. A review was performed of any literature to our best knowledge concerning the effects of pharmacologic agents, environmental changes, and surgical intervention on the microbiome of the upper gastrointestinal tract. Searches of the literature were performed using specific keywords related to drugs, surgical procedures, and environmental factors. Many prescription and nonprescription drugs that are commonly used have varying effects on the upper gastrointestinal tract. Proton pump inhibitors may affect the relative prevalence of some organisms in the lower esophagus and have less effect in the proximal esophagus. Changes in the esophageal microbiome correlate with some esophageal diseases. Drugs that induce weight loss have also been shown to affect the microbiomes of the esophagus and stomach. Common surgical procedures are associated with shifts in the microbial community in the gastrointestinal tract. Environmental factors have been shown to affect the microbiome in the upper gastrointestinal tract, as geographic differences correlate with alterations in the microbiome of the gastrointestinal tract. Understanding the association of environmental and pharmacologic changes on the microbiome of the upper gastrointestinal tract will facilitate treatment plans to reduce morbidity from disease.
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Manasa, Manne, Palakurthi Muralikrishna, and L. R. S. Girinadh. "Endoscopic resection as a primary palliative therapy for advanced primary malignant melanoma of the esophagus." Journal of Digestive Endoscopy 08, no. 01 (January 2017): 29–32. http://dx.doi.org/10.4103/0976-5042.202819.
Full textAbstract:
AbstractPrimary malignant melanoma of the esophagus is a rare aggressive malignant tumor with poor prognosis. It usually presents as dysphagia and retrosternal chest pain. Diagnosis is made by endoscopy and biopsy, and staging is done by computed tomography (CT) scan and fluorodeoxyglucose positron emission tomography scan. The mainstay of treatment is usually surgical with curative or palliative intent since radiotherapy and chemotherapy do not improve the outcome. Here, we report a case of 50-year-old female patient who presented with dysphagia. Esophagogastroduodenoscopy was done, which revealed a large black-colored polypoid lesion occluding the entire lumen of the esophagus. Histopathology confirmed it as malignant melanoma. CT of the chest was performed which showed a tumor mass extended into mediastinum abutting aorta and multiple mediastinal lymph nodes suggesting an advanced disease. As surgery could not be performed and radiotherapy and chemotherapy have no role, endoscopic resection of mass within the esophagus was done and the defect in the esophageal wall was closed with the clips. The patient was symptomatically improved following the resection. She expired after 3 months due to disseminated diseases.
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Kocsis, Dorottya, Zsolt Tulassay, and Márk Juhász. "Eosinophil oesophagitis étrendi és gyógyszeres vonatkozásai." Orvosi Hetilap 156, no. 23 (June 2015): 927–32. http://dx.doi.org/10.1556/650.2015.30164.
Full textAbstract:
Eosinophilic esophagitis is considered to be a chronic antigen-driven disease whereby food and/or aeroallergens induce a chronic inflammatory infiltrate in the esophagus leading to pathological hyperplasia of the epithelial and muscular layers, fibrosis of the lamina propria and symptoms of dysphagia and food impaction. Eosinophilic esophagitis is often associated with other allergic diseases such as asthma or atopic dermatitis. Current first line treatments of the disease include strict dietary modification and topical anti-inflammatory steroids. In this review the authors summarize currently available treatment strategies of eosinophilic esophagitis. Orv. Hetil, 2015, 156(23), 927–932.
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Gruzdev, Oleg. "Differential diagnosis of dysphagia in the elderly." Spravočnik vrača obŝej praktiki (Journal of Family Medicine), no. 1 (January 1, 2020): 44–48. http://dx.doi.org/10.33920/med-10-2001-06.
Full textAbstract:
Dysphagia is a disorder of the swallowing. The causes of dysphagia are inflammatory processes in the oral cavity, pharynx, esophagus, larynx, mediastinum, foreign bodies, cicatricial strictures and tumors, diffuse esophageal spasm, antipsychotic therapy, and some nervous diseases. It is manifested by difficulties or inability to swallow, pain during swallowing, food or liquid getting into the nose, larynx, trachea. Treatment for dysphagia consists in elimination of the underlying cause of dysphagia.
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Grin, A. A., and D. S. Kasatkin. "CERVICAL SPINE INSOLVENT FIXATION IN THE CASES OF ITS TRAUMAS AND DISEASES." Journal of Clinical Practice 8, no. 2 (June 15, 2017): 49–55. http://dx.doi.org/10.17816/clinpract8249-55.
Full textAbstract:
The work represents the analysis of surgery treatment of 552 patients with traumas and degenerative diseases of cervical spine subaks level (CSSL) who were treated in Scientific Research Insnitute of Emergency Care n.a. N.V. Sklifosofsky neurosurgery department since 01.01.2001 to 31.12.2013 and who underwent 554 surgeries. 19 (3.4%) patients had complications connected with the incorrect installation of a stabilizing system and insolvent fixation of a spine. 5 other patients were moved from other hospitals with instrumental confirmed dislocation of ventral plate fragments and damages of the esophagus. The aim of this work is to define risk factors, frequency and causes of complications connected with unsatisfactory fixation of CSSL of patients with trauma and degenerative diseases of cervical spine subaks level.
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Akaishi, Ryujiro, Yusuke Taniyama, Tadashi Sakurai, Takahiro Heishi, Hiroshi Okamoto, Chiaki Sato, Kai Takaya, Shota Maruyama, and Takashi Kamei. "PS01.110: ACUTE NECROTIZING ESOPHAGITIS WITH ESOPHAGUS PERFORATION, TREATED BY THORACOSCOPIC ESOPHAGECTOMY." Diseases of the Esophagus 31, Supplement_1 (September 1, 2018): 81. http://dx.doi.org/10.1093/dote/doy089.ps01.110.
Full textAbstract:
Abstract Background Acute necrotizing esophagus is defined as the diffuse black pigmentation of the esophagus due to the necrosis of the esophageal mucosa, and so called ‘black esophagus’ from its endoscopic findings. The prevalence is only 0.001∼0.2%, although the mortality rate is up to 32%. Methods 67 years old female with medical history of diabetes mellitus, transported to the emergency room with hematemesis and conscious disorder. She had suffered from nausea and epigastralgia for two days. Her general status was in shock vitals and didn’t respond to rehydration. After intubation, emergency endoscopic examination revealed black pigmentation of the esophageal mucosa and diagnosed as acute necrotizing esophagitis. Antibiotics and blood absorption therapy had been started and the patient gradually stabilized. 1 week after the admission, esophagus perforation was suspected from the significant increase of the right pleural effusion and free air at the esophagus wall and the mediastinum on CT scan. Emergency thoracoscopy was performed and found that the esophagus was edematous and adventitia was colored into black. The esophagectomy with esophagostomy and enterostomy was performed. Results On resected specimen, mucosal necrosis was found only on squamous epithelium with three perforating areas in the middle to lower thoracic esophagus. No signs of inflammation nor ischemia was found on the gastric mucosa of the esophagogastric junction. After the operation, patient recovered generally well, except the severe stenosis of the cervical esophagus had developed. Although endoscopic dilation had been constantly performed, the reconstruction remains unsolved issue. Conclusion In acute necrotizing esophagitis, stabilization of the patient's condition by treating comorbid diseases is extremely important. Improving the nutritional status in addition to the administration of antacids and antibiotics is also required. Surgical intervention should be performed when perforating mediastinitis or abscess formation occurs. Primary closure shouldn’t be attempted, and esophageal resection with delayed reconstruction should be considered in addition to drainage. In this case, we could successfully rescued the patient with necrotic esophagitis by performing surgical intervention promptly. It is important to detect the esophagus perforation and mediastinitis early, not to miss the chance of surgical intervention for curative treatment. Disclosure All authors have declared no conflicts of interest.
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Kletkin, Maksim Evgenievich, Vladimir Ibragimovich Temirbulatov, and Denis Vladimirovich Tarabrin. "Perforation of the Esophageal Wall due to Large-Sized Foreign Body Entering the Esophagus." Journal of Experimental and Clinical Surgery 15, no. 1 (March 23, 2022): 64–69. http://dx.doi.org/10.18499/2070-478x-2022-15-1-64-69.
Full textAbstract:
Foreign bodies entering the esophagus may result from rapid food intake, reduced sensitivity of the mucous membrane of the oral cavity in some neurological diseases, under mental illness, in individuals of certain professions. In 3-4% of cases, this results in perforations of the esophagus due to either presence of acute traumatic margins of the foreign body, or by a long-term presentation of a foreign body in the esophagus and, consequently, the development of a pressure injury. Considering the above, timely and complete diagnosis and adequate surgical treatment in the first hours after diagnosed esophageal perforation by a foreign body is a must.
The patient was admitted to the department of thoracic surgery with complaints of a foreign body in the throat, hypersalivation, subcutaneous emphysema of the neck. He felt sick 2 hours ago, when during sleep he had swallowed a denture. The patient was examined and diagnosed with a foreign body of the upper third of the esophagus with perforation. He was urgently administered: 1. fibroesophagoscopy + reduction of the foreign body in the stomach; 2. Left-sided colotomy, suturing of the upper thoracic esophagus, drainage of the prevertebral space; 3. Upper median laparotomy, gastrotomy, removal of a foreign body, gastrostomy according to Kaders method. The patient was discharged with a gastrostomy from the hospital in a satisfactory condition, he was recommended follow-up observation by a local surgeon in the outpatient clinic. The gastrostomy was closed conservatively 3 weeks after the discharge. In 2 weeks after the closure of gastrostomy, the patient returned to a full life and working activity.
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Garganeeva, N. P., M. F. Belokrylova, A. K. Kostin, A. P. Koshel, E. M. Epanchintseva, V. F. Lebedeva, M. M. Aksenov, et al. "Comorbidity of esophageal achalasia, mixed anxiety and depressive reaction in a young female patient: problems of diagnosis and treatment." Bulletin of Siberian Medicine 18, no. 2 (August 11, 2019): 290–98. http://dx.doi.org/10.20538/1682-0363-2019-2-290-298.
Full textAbstract:
Achalasia cardia (“cardiospasm”, “phrenospasm”, “dolichoesophagus”, “megaesophagus”, “stenosis of cardia”) represents a primary impairment of esophageal motor function associated with impaired lower esophageal sphincter relaxation and peristalsis defects of the thoracic esophagus. It is diagnosed at the age of 25 to 60 years, making up to 20% of all diseases of the esophagus, and is characterized by a triad of symptoms: dysphagia, regurgitation and chest pain when swallowing. In most cases the first manifestations of achalasia are preceded by stress situations in the anamnesis that complicates the differential diagnosis of psychogenic esophageal spasm. The presented clinical case illustrates difficulties of early diagnosis of achalasia cardia in a young femalepatient with severe anxiety and depressive symptoms which develop under conditions of chronic stressful situations in the family or at work. The issues of interdisciplinary interaction of health professionals (physician, gastroenterologist, psychiatrist, psychotherapist, and surgeon) on the course of examination and management of patients with comorbid physical and mental pathology are discussed. The efficiency of the integrative approach to treatment and rehabilitation with the use of modern reconstructive surgical interventions as well as conservative methods of therapy, psychopharmacotherapy and personality-oriented psychotherapy proves the relevance of studying psychosomatic aspects of achalasia cardia.
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Vidovic, Vladimir, Ivan Nikolic, Jelena Vukojevic, Golub Samardzija, Biljana Kukic, Bogdan Bogdanovic, and Nemanja Petrovic. "Unusual metastasis of esophageal cancer." Vojnosanitetski pregled 71, no. 10 (2014): 975–77. http://dx.doi.org/10.2298/vsp1410975v.
Full textAbstract:
Introduction. Carcinoma of the esophagus is in the eighth place by the frequency of malignant diseases and the sixth cause of death from cancer worldwide. It usually metastasizes to regional lymph nodes, liver, lungs, central nervous system, and bones, but metastases can appear to unusual locations such as facial skin and lips. Case report. We presented a 56- year-old man who reported to his physician because of upper lip swelling. A physical checkup of the patients also showed a lesion on the skin of the left temporal region and both lesions were biopsied. Based on the results of histopathological and immunohistochemical analyses of the samples a diagnosis of metastatic adenocarcinoma to the skin was established. Additional diagnostic procedures, including esophagogastroduodenoscopy, detected the infiltration into the distal part of esophagus, which was histopathologically confirmed as adenocarcinoma of esophagus. The results of positron emission tomography/computed tomography (PET/CT) examination showed the invasion of the disease. Because of the disease expansion, a multidisciplinary oncology team suggested chemo- and radiotherapy treatment. The patient has received 4 cycles of platinum-based chemotherapy so far. Conclusion. The physicians should always consider unusual skin lesions as the first sign of cancer spreading.
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Karim, Mohammad Enamul, Sayeda Rahim, Mohammad Mahmuduzzaman, Dilip Kumar Ghosh, Atiqul Islam, Habib Ahmed, and AHM Rowshon. "Review Article: Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease." Journal of Shaheed Suhrawardy Medical College 8, no. 1 (March 7, 2017): 30–33. http://dx.doi.org/10.3329/jssmc.v8i1.31504.
Full textAbstract:
Gastro Esophageal Reflux Disorders(GERD) are group of conditions where gastric contents are refluxed into the esophagus and produce troublesome symptoms mainly heartburn and regurgitation. It may present with complications as well. Atypical presentation is also not very uncommon. Proper diagnosis and differentiation from other diseases can ensure appropriate treatment and thus better quality of life. Unlike many other diseases, diagnosis of GERD is relatively straight forward through symptomatology and a few investigations, even though few cases require special and technologically newer modalities of investigative tools for confirmation. Option for treatment are many and mostly medical; surgical and other methods are very rarely needed to pose better life. New molecules are recently being used with variable promising results and need exploration.J Shaheed Suhrawardy Med Coll, June 2016, Vol.8(1); 30-33
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Nakamura, Jun, Takuto Hikichi, Minami Hashimoto, Mika Takasumi, Tsunetaka Kato, Ryoichiro Kobashi, Takumi Yanagita, et al. "Efficacy and Safety of Peroral Endoscopic Myotomy for Esophageal Achalasia and Achalasia-Related Diseases in Patients Aged 75 Years and Over." Healthcare 9, no. 12 (December 1, 2021): 1668. http://dx.doi.org/10.3390/healthcare9121668.
Full textAbstract:
Peroral endoscopic myotomy (POEM) has become a popular treatment for esophageal achalasia and other esophageal motility disorders. However, its efficacy and safety in elderly patients are unclear. To clarify that, we reviewed the medical records of patients who underwent POEM in our hospital. A total of 11 patients who underwent POEM for esophageal achalasia (n = 10) and jackhammer esophagus (n = 1) were included. Procedural success, defined as the completion of an esophageal and gastric myotomy, was 100%. Clinical success, defined as an Eckardt score of 3 or less, without the use of additional treatments at 2 months, was 100%. The median Eckardt score significantly decreased after the POEM (baseline vs. 2 months after POEM; 7 (2–8) vs. 0 (0–1), p < 0.01). In the second and third years, the cumulative treatment effect maintenance rate was 88.9%. All patients taking antithrombotic agents had safe operations with the temporary discontinuation of these agents. There were four adverse events (two pneumoperitoneum, one mucosal injury, and one pneumonia), all of which improved with fasting or antibiotics. In conclusion, POEM is an effective and safe treatment for esophageal achalasia and achalasia-related diseases in patients aged 75 years and over.
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Maev, I. V., G. L. Yurenev, E. M. Mironova, and T. V. Yureneva-Thorzhevskaya. "Phenotype of obesity and gastroesophageal reflux disease in the context of comorbidity in patients with cardiovascular diseases." Terapevticheskii arkhiv 91, no. 2 (February 15, 2019): 126–33. http://dx.doi.org/10.26442/00403660.2019.02.000099.
Full textAbstract:
The relevance of studying such problems as gastroesophageal reflux disease (GERD) and obesity is caused by their high prevalence in the developed countries of the world. Epidemiological data indicate that obesity is a significant risk factor for developing GERD due to increased intra-abdominal pressure and gastroesophageal gradient, slowing of gastric evacuation and formation of hiatal hernia. Abdominal obesity increases the likelihood of complications of GERD: erosive esophagitis, Barrett's esophagus and adenocarcinoma. This fact is connected with humoral influences: increased production of pro-inflammatory cytokines and leptin, and decreased secretion of adiponectin. Treatment of comorbid patients requires higher dosages and longer courses of antisecretory medicines, and an additional prescription of ursodeoxycholic acid.
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Karamchandani, Dipti M., Qin Zhang, Xiao-Yan Liao, Jing-Hong Xu, and Xiu-Li Liu. "Inflammatory bowel disease- and Barrett’s esophagus-associated neoplasia: the old, the new, and the persistent struggles." Gastroenterology Report 7, no. 6 (August 13, 2019): 379–95. http://dx.doi.org/10.1093/gastro/goz032.
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Abstract Early diagnosis of and adequate therapy for premalignant lesions in patients with inflammatory bowel disease (IBD) and Barrett's esophagus (BE) has been shown to decrease mortality. Endoscopic examination with histologic evaluation of random and targeted biopsies remains the gold standard for early detection and adequate treatment of neoplasia in both these diseases. Although eventual patient management (including surveillance and treatment) depends upon a precise histologic assessment of the initial biopsy, accurately diagnosing and grading IBD- and BE-associated dysplasia is still considered challenging by many general as well as subspecialized pathologists. Additionally, there are continuing updates in the literature regarding the diagnosis, surveillance, and treatment of these disease entities. This comprehensive review discusses the cancer risk, detailed histopathological features, diagnostic challenges, and updates as well as the latest surveillance and treatment recommendations in IBD- and BE-associated dysplasia.
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Taghavyan, Nina Jalily, Arshide Mashayekh, Hamid Reza Pouraliakbar, Jamal Moosavi, Omid Shafe, Bahram Mohebbi, and Parham Sadeghipour. "Spontaneous Intramural Esophageal Hematoma Secondary to Thrombolysis in the Setting of Pulmonary Embolism." Vascular and Endovascular Surgery 55, no. 5 (February 8, 2021): 510–14. http://dx.doi.org/10.1177/1538574421989863.
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Intramural hematoma of the esophagus (IHE) represents a rare condition on the spectrum of esophageal injuries. The most common symptoms are hematemesis, epigastric pain or retrosternal chest pains, odynophagia, and dysphagia. Early recognition of IHE is important as it may mimic other diseases such as myocardial infarction, pulmonary embolism, Mallory–Weiss tears, Boerhaave’s syndrome, ruptured aortic aneurysms, and aortic dissection. Computed tomography is the preferred investigation method, and treatment is usually conservative. We herein present 2 cases of IHE associated with catheter-directed thrombolysis in the setting of pulmonary embolism.
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Trofimov, M. V., V. G. Korpusenko, S. O. Muntyan, G. E. Kuznetsov, and V. V. Gromov. "CLINICAL AND STATISTICAL ASPECTS OF THE DEVELOPMENT AND COURSE OF BLEEDING FROM VARICOSE VEINS OF THE ESOPHAGUS IN PATIENTS WITH PORTAL HYPERTENSION." Kharkiv Surgical School, no. 1 (March 20, 2021): 46–51. http://dx.doi.org/10.37699/2308-7005.1.2021.09.
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Summary. The aim of the study was to identify the main etiological factors that led to the development of portal hypertension — the leading cause of varicose bleeding, to analyze the clinical aspects of the course and methods of treatment of bleeding from varicose veins of the esophagus (EVV).
Materials and methods. We collected, processed and analyzed the results of treatment of 95 patients with bleeding from varicose veins of the esophagus hospitalized in the Dnipro Clinical Emergency Hospital, DGS “for 2017. The leading factor was established liver cir-rhosis — 92 cases (96.8 %). Moreover, in 42 cases (44.2 %), cirrhosis of the liver developed against the background of chronic viral hepatitis C. The endoscopic picture of this category of patients and the degree of blood loss were also assessed.
Results and its discussion. It was found that the most frequently detected VRV II–III st. — in 42 (44.2 %), III st. — in 27 (28.4 %), while 52 (54.7 %) patients showed dilatation of the venous trunks in all parts of the esophagus, in 29 (30.5 %) — in the mid-lower parts. Analysis of concomitant pathology helped to establish against the background of which diseases portal hypertension most often develops: viral hepatitis C was detected in 46 cases (48.4 %), coronary artery disease (diffuse cardiosclerosis) — in 29 (30.5 %), ischemic heart disease (atherosclerotic cardiosclerosis) — in 15 (15.8 %), hypertension II Art. — 26 (27.4 %), diabetes mellitus — 10 (10.6 %). All patients received conservative therapy, which was combined with mechanical methods of hemostasis (Sengstaken – Blakemore probe) in 24 cases (25.3 %), endoscopic hemostasis (ligation with latex rings) — in 3 cases (3.2 %), partial embolization of the splenic artery — in 3 cases (3.2 %), suturing of veins — in 1 (1.1 %). In 70 cases (73.7 %) a favorable outcome was noted, 25 cases (26.3 %) were fatal.
Conclusions. The main cause of bleeding from varicose veins of the esophagus is liver cirrhosis developed against the background of viral hepatitis C. Despite the widespread use of local endoscopic hemostasis techniques, recurrent bleeding occurs in 9.5 % of cases. The mortality rate for bleeding from varicose veins of the esophagus is 26.3 %, which corresponds to the world average trend.
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Milosevic, Ivana, Milos Korac, and Branko Brmbolic. "Diagnosis and treatment of esophageal diseases in patients with acquired immunodeficiency syndrome in Serbia." Medical review 63, no. 11-12 (2010): 779–83. http://dx.doi.org/10.2298/mpns1012779m.
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Introduction. Gastrointestinal complications are common manifestations of acquired immune deficiency syndrome. The aim of this study was to establish the type and frequency of esophageal disease, the influence of antiretroviral therapy on it and the most adequate approach to this group of patients. Material and methods. This study included 146 patients with acquired immune deficiency syndrome treated at the Institute of Infectious and Tropical Diseases of Clinical Centre in Serbia from 1991-2001. The statistical data processing was done by the Statistical Package for the Social Sciences for Windows version 10.0. The level of statistical significance was defined to be p?0.05 and p?0.01. The diagnosis was made upon endoscopic exams, pathohistological findings and isolation of causative agents. Results. Esophagitis was found in 78 (53.41%) patients. These patients complained mostly of odynophagia and dysphagia. The most common was Candida esophagitis. It was diagnosed in 59 (40.41%) patients; 5 patients (3.42%) had cytomegalovirus esophagitis; 2 patients (1.37%) had herpes simplex virus esophagitis, and one-patient (0.68%) had a mixed Candida and herpes simplex virus infection of esophagus. Idiopathic esophageal ulcer was diagnosed in one (0.68%) patient. Conclusion. Seventy-eight (53.41%) patients with acquired immune deficiency syndrome had esophagitis. Candida (40.41%) was the most common cause of esophagitis. Viral esophagitis was less common: cytomegalovirus in 5 patients (3.42%); herpes simplex virus in 2 patients (1.37%), and idiopathic esopghageal ulcer in 1 patient (0.68%)). These patients complained mostly of odynophagia and dysphagia. Modern antiretroviral therapy reduces the frequency of esophagitis and therefore changes symptomatology in patients with acquired immune deficiency syndrome.
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Kwiecien, Slawomir, Marcin Magierowski, Jolanta Majka, Agata Ptak-Belowska, Dagmara Wojcik, Zbigniew Sliwowski, Katarzyna Magierowska, and Tomasz Brzozowski. "Curcumin: A Potent Protectant against Esophageal and Gastric Disorders." International Journal of Molecular Sciences 20, no. 6 (March 24, 2019): 1477. http://dx.doi.org/10.3390/ijms20061477.
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Turmeric obtained from the rhizomes of Curcuma longa has been used in the prevention and treatment of many diseases since the ancient times. Curcumin is the principal polyphenol isolated from turmeric, which exhibits anti-inflammatory, antioxidant, antiapoptotic, antitumor, and antimetastatic activities. The existing evidence indicates that curcumin can exert a wide range of beneficial pleiotropic properties in the gastrointestinal tract, such as protection against reflux esophagitis, Barrett’s esophagus, and gastric mucosal damage induced by nonsteroidal anti-inflammatory drugs (NSAIDs) and necrotizing agents. The role of curcumin as an adjuvant in the treatment of a Helicobacter pylori infection in experimental animals and humans has recently been proposed. The evidence that this turmeric derivative inhibits the invasion and proliferation of gastric cancer cells is encouraging and warrants further experimental and clinical studies with newer formulations to support the inclusion of curcumin in cancer therapy regimens. This review was designed to analyze the existing data from in vitro and in vivo animal and human studies in order to highlight the mechanisms of therapeutic efficacy of curcumin in the protection and ulcer healing of the upper gastrointestinal tract, with a major focus on addressing the protection of the esophagus and stomach by this emerging compound.
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Clemons, Karl V., and David A. Stevens. "Efficacy of Ravuconazole in Treatment of Mucosal Candidosis in SCID Mice." Antimicrobial Agents and Chemotherapy 45, no. 12 (December 1, 2001): 3433–36. http://dx.doi.org/10.1128/aac.45.12.3433-3436.2001.
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ABSTRACT A model of orogastric candidosis in SCID mice, which mimics disease seen in AIDS patients, was used to evaluate ravuconazole in comparison with fluconazole for treatment. Mice were infected orally withCandida albicans and received either no treatment or oral treatment once daily for 12 days with 1, 5, or 25 mg of ravuconazole per kg of body weight per day, 5 or 25 mg of fluconazole per kg per day, or diluent (10% dimethyl sulfoxide in 0.5% carboxymethyl cellulose). The numbers of C. albicans CFU in the esophagus, stomach, small intestine, and cecum on day 25 in mice given no treatment and diluent were equivalent. Both doses of fluconazole significantly reduced numbers of CFU in all four tissues but were equivalent to each other. Ravuconazole showed dose-responsive improvement of clearance of CFU. Ravuconazole at 25 mg/kg was superior in reduction of numbers of CFU in all tissues to controls or 25 mg of fluconazole per kg and to other regimens in at least three tissues. Fluconazole at 25 mg/kg cured no infection in any tissue, whereas 25 mg of ravuconazole/kg cleared infection in all tissues from 50% of mice. Ravuconazole has good efficacy and the potential to cure mucosal candidosis in the absence of a functional immune response.
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Starostina, S. V., V. M. Makhov, O. A. Storonova, A. V. Bolshakov, I. V. Kuprina, A. S. Trukhmanov, and V. T. Ivashkin. "Сapabilitу of 24-hour esophageal pH-impedance monitoring in the diagnosis of GERD-associated laryngeal diseases." Meditsinskiy sovet = Medical Council, no. 16 (November 14, 2020): 62–72. http://dx.doi.org/10.21518/2079-701x-2020-16-62-72.
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Extraesophageal manifestations of gastroesophageal reflux disease (GERD), despite the improvement of methods of diagnosis and treatment of patients with this pathology, still remain an urgent problem of medicine and cause increased attention of clinicians and researchers. In some cases, patients with GERD do not present typical complaints of heartburn, regurgitation; the disease may manifest extraesophageal manifestations, such as chronic cough, hoarseness, reflux laryngitis, and others caused by the presence of laryngopharyngeal reflux (LFR) – inflammation of the mucous membrane of the upper digestive and respiratory tracts with possible morphological changes associated with direct and indirect (reflex) exposure to gastroduodenal reflux. The occurrence of LFR is possible due to a violation of the motor function of the esophagus and insufficiency of the upper esophageal sphincter, as well as a decrease in the tone of the pharyngeal muscles. The most accessible methods of diagnosis of LFR are registration of complaints according to the questionnaire “index of reflux symptoms”, assessment of the clinical and functional state of the larynx using a visually analog “scale of reflux signs”. A positive response to the empirical use of proton pump inhibitors in combination with procinetics and determination of pepsin content in saliva can also be alternative diagnostic methods. To date, 24-hour pH-impedance monitoring is a method that allows the most accurate diagnosis of all types of reflux, regardless of the pH value, to verify high reflux in combination with its physical properties, as well as to estimate the time of chemical and volumetric esophageal clearance. In addition to performing esophagogastroduodenoscopy, the use of this method is indicated in patients with suspected extraesophageal manifestations of GERD. The article presents clinical examples of patients with extraesophageal manifestations of GERD, describes the possibilities of 24-hour pH-impedance monitoring of the esophagus in the diagnosis of LFR and reflux-associated diseases of the larynx.
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Trukhmanov, A. S., A. A. Makushina, O. A. Storonova, and N. Yu Ivashkina. "Evaluation and management of infectious esophagitis in immunocompromised patients and immunocompetent individuals." Terapevticheskii arkhiv 92, no. 8 (September 3, 2020): 108–17. http://dx.doi.org/10.26442/00403660.2020.08.000763.
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Among the many causes of the inflammatory process in the esophagus, infectious diseases are becoming increasingly important due to their steady growth. Previously esophageal infections have traditionally been associated with immunodeficiency syndromes, but now in clinical practice, these disorders are becoming increasingly recognized in immunocompetent individuals. Early diagnosis of infectious esophagitis is necessary to develop effective treatment tactics, and, as a result, reduce the risk of complications and adverse outcomes of the disease. This study reviewed the most clinical relevant pathogens of infectious esophagitis, both among patients with immunodeficiency and among healthy individuals. Specific diagnostic, risk factors, clinical presentation and therapeutic features were considered depending on the immune status of patients.
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Popa, Cristian Constantin, Dumitru Cristinel Badiu, Liliana Florina Andronache, Radu Virgil Costea, Stefan Ilie Neagu, Anca Pantea Stoian, Bogdan Socea, and Dorin Ionescu. "Differential Diagnosis in Esophageal Cancer. Review on literature." Revista de Chimie 70, no. 1 (February 15, 2019): 331–35. http://dx.doi.org/10.37358/rc.19.1.6911.
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Esophageal cancer represents a neoplasm that is thought to have both an increased incidence and prevalence in the following years. Although much progress has been made in the detection and the early treatment of esophageal cancer, the prognosis is still limited, and mortality remains very high. The most common histological types of esophageal cancer are squamous cell carcinoma, and, respectively, adenocarcinoma. Lately, there has been an accelerated increase in the incidence of adenocarcinoma, in the context of increased prevalence of gastro-esophageal reflux disease and obesity, but also of the current alimentary diet, especially in developed countries. The esophagus has its anatomical features. Moreover, it is located topographicallyin a complex cervico-thoraco-abdominal area, unique for a viscus. From the clinical point of view, the onset of symptoms of esophageal cancer is insidious. For these reasons, special attention should be pain in the early detection and differentiation of this neoplasm from other pathologies. These pathologies are very varied and may comprise other esophageal diseases, neighborhood pathologies such as cervical, thoracic, abdominal, systemic pathologies (immunologic, infectious) or other pathologies such as the oro-maxillo-facial, oculo-orbital, vascular, muscular, and cutaneous ones. Keywords: esophagus, cancer, differential diagnosis