Dissertations / Theses on the topic 'Erythropoietin'
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Leng, Henry Martin John. "The biogenesis of erythropoietin during inflammation." Doctoral thesis, University of Cape Town, 1995. http://hdl.handle.net/11427/27051.
Full textAfrasiabi, Morteza. "Biochemical studies of erythropoietin and erythropoietin receptors." Thesis, Queen's University Belfast, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334533.
Full textMcNamee, P. T. "A study of erythropoietin and factors regulating erythropoiesis in chronic renal failure." Thesis, Queen's University Belfast, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374226.
Full textCervellini, Ilaria. "Neuroprotection by erythropoietin." Thesis, University of Brighton, 2012. https://research.brighton.ac.uk/en/studentTheses/1075c7e4-6f7d-4f53-b83e-42671edac8ca.
Full textKrosl, Jana. "The role of erythropoietin and erythropoietin receptor in regulation of hemopoiesis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq25081.pdf.
Full textZhang, Yingxin. "Symmetric signaling by an asymmetric 1 erythropoietin : 2 erythropoietin receptor complex." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/45211.
Full textIncludes bibliographical references (p. 43-46).
One erythropoietin molecule binds asymmetrically to two identical receptor monomers via erythropoietin site 1 and site 2, although it is unclear how asymmetry affects receptor activation and signaling. Here we report the computational design and experimental validation of two mutant erythropoietin receptors: one that binds only to erythropoietin site 1 but not site 2, and one that binds only to site 2 but not site 1. Expression of either mutant receptor alone in Ba/F3 cells cannot elicit a signal in response to erythropoietin, but when co-expressed, there is a proliferative response and activation of the JAK2 Stat5 signaling pathway. A truncated erythropoietin receptor with only one cytosolic tyrosine (Y343), on only one receptor monomer is sufficient for signaling in response to erythropoietin, regardless of the monomer on which it is located. The same results apply to having only one conserved juxtamembrane hydrophobic L253 or W258 residue, essential for JAK2 activation, in the full-length receptor dimer. We conclude that despite asymmetry in the ligand-receptor dimer interaction, both sides are competent for signaling, and we suggest that the receptors signal equally.
by Yingxin Zhang.
M.Eng.
Yu, S. R. "Cytoprotective mechanisms of erythropoietin and erythropoietin derivatives in peripheral arterial disease." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1458006/.
Full textChang, Kai-Hsin 1974. "Erythropoietin, erythropoiesis, and malarial anemia : the mechanisms and implications of insufficient erythropoiesis during murine blood-stage malaria." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84490.
Full textRolfes, Simone [Verfasser]. "Einfluss von Erythropoietin und Erythropoietin-Isoformen auf die murine Neurogenese / Simone Rolfes." Berlin : Freie Universität Berlin, 2016. http://d-nb.info/108193543X/34.
Full textBarbeau, Paule. "Markers of the erythropoietin, erythropoietin receptor and RAD genes and cardiorespiratory endurance." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq25376.pdf.
Full textLipšic, Erik. "Erythropoietin in cardiac ischemia." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2006. http://irs.ub.rug.nl/ppn/293076030.
Full textSharples, Edward John. "Pleiotropic effects of erythropoietin." Thesis, Queen Mary, University of London, 2011. http://qmro.qmul.ac.uk/xmlui/handle/123456789/2351.
Full textLanger, Juliane [Verfasser]. "Untersuchungen zur Erythropoietin-Konzentration im Urin Frühgeborener nach Applikation von rekombinantem Erythropoietin / Juliane Langer." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2012. http://d-nb.info/1028496087/34.
Full textRichardson, Dominique. "Synthesis of neo-glycosylated human erythropoietin and investigation into interaction with the erythropoietin receptor." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/synthesis-of-neoglycosylated-human-erythropoietin-and-investigation-into-interaction-with-the-erythropoietin-receptor(6c7e44b5-e7f4-46b7-beb0-cd7f8b15b757).html.
Full textZhang, Ji. "Mechanisms of erythroid proliferation and differentiation analysis of the role of erythropoietin receptor in the friend virus model /." View the abstract Download the full-text PDF version (on campus access only), 2008. http://etd.utmem.edu/ABSTRACTS/2008-025-JiZhang-index.html.
Full textTitle from title page screen (viewed on October 7, 2008 ). Research advisor: Paul A. Ney, M.D. Document formatted into pages (xi, 122 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 78-110).
Maxwell, P. H. "Regulation of the erythropoietin gene." Thesis, University of Oxford, 1994. http://ora.ox.ac.uk/objects/uuid:86a152eb-cfc8-4812-935e-c89ab48acee3.
Full textStewart, J. P. "Erythropoietin-induced genes and the erythropoietin receptor : their possible role in the pathogenesis of multiple myeloma." Thesis, Queen's University Belfast, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396562.
Full textGörden, Stephan [Verfasser]. "Untersuchungen zur Erythropoietin- und Erythropoietin-Rezeptor-Expression nach experimenteller spinaler Kontusion in der Ratte / Stephan Görden." Kiel : Universitätsbibliothek Kiel, 2018. http://d-nb.info/1164012509/34.
Full textMcKeveney, Paul J. "Characterisation of novel erythropoietin-responsive genes." Thesis, Queen's University Belfast, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301746.
Full textMurthy, Sudish C. "An examination of in vitro erythropoiesis by utilizing agents that mimic the in vitro activity of erythropoietin." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26503.
Full textMedicine, Faculty of
Pathology and Laboratory Medicine, Department of
Graduate
Mattar, Julia Eva. "Einfluss von Adenosin-2'-3'-Dialdehyd auf das Methylierungspotential und die Genexpression in HepG2-Zellen unter normoxischen Bedingungen." [S.l. : s.n.], 2004.
Find full textWirtz, Joris Jeroen Johannes Maria. "Hemodynamic and hemostatic effects of erythropoietin therapy." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1993. http://arno.unimaas.nl/show.cgi?fid=5887.
Full textSmith, Katie. "The impact of erythropoietin on uraemic cardiomyopathy." Thesis, University of Hull, 2009. http://hydra.hull.ac.uk/resources/hull:2679.
Full textTam, Robert C. "Aspects of the physiology of erythropoietin secretion." Thesis, Open University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278491.
Full textKobayashi, Toshihiro. "Production of Erythropoietin in the Reproductive Organs." Kyoto University, 2003. http://hdl.handle.net/2433/148962.
Full text0048
新制・課程博士
博士(農学)
甲第10233号
農博第1305号
新制||農||862(附属図書館)
学位論文||H15||N3754(農学部図書室)
UT51-2003-H654
京都大学大学院農学研究科応用生命科学専攻
(主査)教授 永尾 雅哉, 教授 伏木 亨, 教授 吉川 正明
学位規則第4条第1項該当
Rosenlöf, Katarina. "Erythropoietin receptor and comparison with renin substrate /." Hki : Societas scientiarum Fennica : Academic Bookstore [distr.], 1987. http://catalog.hathitrust.org/api/volumes/oclc/57854069.html.
Full textTiivistelmä ja 5 erip. - Tiivistelmä ilm. myös erillisenä. - Nimiösivulla myös: From the Minerva Foundation Institute for Medical Research, Unit of Clinical Physiology, and the Fourth Department of Medicine, University of Helsinki.
Breggia, Anne C. "The JAK2/Y343/STAT 5 Signaling Axis is Required for Erythropoietin - Mediated Protection against Ischemic Injury in Renal Tubular Epithelial Cells." Fogler Library, University of Maine, 2008. http://www.library.umaine.edu/theses/pdf/BreggiaAC2008.pdf.
Full textPaul, Christina. "Expression und Wirkung von Erythropoietin ß bei Astrozyten unter normoxischen und hypoxischen Bedingungen." [S.l. : s.n.], 2007.
Find full textMayuzumi, Daisuke. "Role of receptor ubiquitination in erythropoietin receptor signaling." Diss., University of Iowa, 2010. https://ir.uiowa.edu/etd/854.
Full textLau, Monique [Verfasser]. "Wechselwirkungen der Transkriptionsmodulatoren Wt1, Gata4 und Retinsäure mit dem Erythropoietin/Erythropoietin-Rezeptor-System des embryonalen Herzens der Maus / Monique Lau." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2021. http://d-nb.info/1234985071/34.
Full textPham, Michael N. "Erythropoietin Stimulation of Mitochondrial Protein Content - A Potential Mechanism through Direct Binding of Erythropoietin Receptor and AMP-Activated Protein Kinase." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/321354.
Full textSauer, Katja. "Inhibition der Müllerzellschwellung durch Erythropoietin unter hypotonen Bedingungen." Doctoral thesis, Universitätsbibliothek Leipzig, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-105242.
Full textHardy, Sinead M. "Nanoparticles versus microarrays in the detection of erythropoietin." Thesis, University of East Anglia, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502039.
Full textMaxwell, Alexander Peter. "Studies of the biology and pharmacology of erythropoietin." Thesis, Queen's University Belfast, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335933.
Full textTaylor, Timothy Nicholas. "Immunochemical studies of erythropoietin in chronic renal failure." Thesis, Queen's University Belfast, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356918.
Full textDaghman, Nureddin A. "A study of the factors regulating erythropoietin production." Thesis, Queen's University Belfast, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337043.
Full textEmanuelsson, Ida, Anna-Karin Jansson, and Katarina Risö. "Characterising of chromatography gels for purification of erythropoietin." Thesis, Högskolan i Borås, Institutionen Ingenjörshögskolan, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-19097.
Full textUppsatsnivå: C
Bullard, Anthony John. "The role of erythropoietin in ischaemia/reperfusion injury." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445332/.
Full textO'Leary, Olivia Eileen. "The therapeutic potential of erythropoietin for ischaemic retinopathies." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.696156.
Full textWallach, Iwona. "Transkriptionelle Regulation des Erythropoietin-Rezeptor-Gens im zentralen Nervensystem." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2007. http://dx.doi.org/10.18452/15685.
Full textSince the use of erythropoietin (Epo) as neuroprotective agent is currently intensively studied in preclinical and clinical trials, regulatory mechanisms of the erythropoietin receptor (EpoR) in neuronal cells are of particular interest. In this study, the transcriptional mechanisms of EpoR regulation were analyzed in human neuroblastoma-derived SH-SY5Y cells, which exhibit a neuronal phenotype. Considering that the hematopoietic transcription factor GATA-1 stimulates EpoR transcription in cooperation with Sp1 in erythroid progenitors, the role of other GATA family members expressed in neuronal precursor cells were studied. In vitro, GATA-2, -3 and -4 were found to bind to two consensus motifs within the EpoR 5’-flanking region (-274/-271 and -47/-44). In reporter gene assays, these regions showed an up to 4.8-fold induction if GATA-2, -3 or -4 were overexpressed. However, forced expression of GATA-2, -3 and -4 did not enhance endogenous EpoR mRNA expression. Under hypoxia (2% O2, 3 d), EpoR expression was significantly upregulated in SH-SY5Y cells (1.8-fold, p < 0.01), but not further increased by the additional overexpression of the GATA factors. Incubation of the SH-SY5Y cells with recombinant Epo (5 U/ml, 3 d) had no effect on the EpoR expression under normoxia or hypoxia. The promoter activities of the reporter constructs were not changed by mutations in the GATA sites, but abolished by mutations of Sp1 binding sites. A fragment (-449/-285) of the 5’-flanking region that contains a cluster of binding sites for various transcription factors showed strongest promoter activity and was obviously directing the recruitment of RNA polymerase II. We conclude that GATA factors do not play a major role in regulating EpoR expression in our model for neuronal precursor cells. EpoR mRNA expression is rather regulated by a complex of various transcription factors, which may bind to a region upstream of the minimal promoter.
Glennie, Judith Lynn. "Is hypertension a determinant of erythropoietin requirements in hemodialysis?" Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0011/MQ41704.pdf.
Full textDi, Giovanni Jessica Louise. "Early second trimester amniotic fluid erythropoietin and pregnancy outcomes." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112615.
Full textDobocan, Monica Crisanti. "Chaperonin 10: an endothelial-derived, erythropoietin- dependent differentiation factor." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40690.
Full textL’érythropoïétine (EPO) stimule les cellules endothéliales à produire différents facteurs qui soutiennent la formation des érythrocytes. En effectuant une électrophorèse-2D / spectrométrie de masse, on a identifié la chapéronine10 (cpn10) comme étant un de ces facteurs. Cpn10 est secrétée par les cellules endothéliales HUVEC après un ajout d’EPO; elle diminue la prolifération des cellules érythroleucémiques K562 et elle stimule la différentiation des érythrocytes TF-1 et des fibroblastes. On a observé qu’une des actions immédiates initiées par cpn10 dans les cellules K562 et TF-1 était de changer significativement la phosphorylation de GSK-3 (glycogen synthase kinase 3) et cofilin-1. Des inhibiteurs de GSK-3 utilisés en présence de cpn10 ou seuls ont altéré le processus de prolifération et différentiation observés auparavant avec les cellules TF-1, en suggérant ainsi que GSK-3 puisse jouer un rôle dans la différentiation cellulaire déclenchée par cpn10. C’est la première fois qu’un lien est décrit entre cpn10 et l’érythropoïèse.
Hamilton, Ross Waring. "The role of erythropoietin in protecting against diabetic retinopathy." Thesis, Queen's University Belfast, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546354.
Full textHufnagel, Maria [Verfasser]. "Genexpression von Erythropoietin durch Präkonditionierung des Zentralnervensystems / Maria Hufnagel." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2009. http://d-nb.info/1027497926/34.
Full textZhang, Fenz. "Regulation of erythropoiesis in a murine model of chronic renal failure : the relative role of erythropoietin and insulin-like growth factor 1." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=69733.
Full textA mouse model of CRF was employed in this investigation. Six weeks after the surgical induction of renal failure, the mice were characterized in terms of biochemical and hematological parameters which included the response to a 3-week treatment with recombinant human EPO (r-HuEPO). Additionally the kidneys, liver and bone marrow were harvested for the determination of the mRNA expression of EPO and IGF-1 as assessed by the reverse transcription polymerase chain reaction followed by Southern blotting. Normal mice and mice rendered anemic by phlebotomy were included in all experiments. (Abstract shortened by UMI.)
Colella, Pasqualina. "Use of erythropoietin derivatives for treatment of retinal degenerative diseases." Thesis, Open University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.548075.
Full textHeld, Hanns-Christoph. "Die akute Wirkung von Erythropoietin am ischämischen Maus- und Schweineherz." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-162319.
Full textAssaraf, Michael I. "The role of erythropoietin and its receptor in Alzheimer disease /." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=81588.
Full textBreen, Marie Elizabeth. "The erythropoietin receptor in TEL-AML1 positive acute lymphoblastic leukaemia." Thesis, Queen's University Belfast, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.579773.
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