Dissertations / Theses on the topic 'Equid herpesvirus'
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Iqbal, Javid. "Investigations into the regulation of latency of equid herpesvirus 1." Thesis, Royal Veterinary College (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265298.
Tearle, Jason Paul. "Pathogenesis of equid herpesvirus-1 infection in the male horse." Thesis, Open University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363489.
Sinclair, Robert. "Equid herpesvirus type-1 : antigenic analysis and diagnosis of infection using monoclonal antibodies." Thesis, Open University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292324.
Brown, Lara Jean. "Failure to detect equid herpesvirus type 1 DNA in Thoroughbred placentae and healthy new-born foals." Diss., University of Pretoria, 2009. http://hdl.handle.net/2263/67946.
Dissertation (MSc)--University of Pretoria, 2017.
Production Animal Studies
MSc
Torelli, Camila Souza. "Ocorrência de anticorpos contra o EHV dos tipos 1 e 4 em animais vacinados e não vacinados do Estado de São Paulo." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-04092012-164102/.
The equine herpesvirus type 1 (EHV-1) and type 4 (EHV-4) are considered the major infectious agents for the equine species. Among the diseases caused by these agents, we highlight the rinopneumonite in young animals, abortion in females in the final third of pregnancy, perinatal mortality in foals and encefalopathy. Previous studies have reported wide spread of EHV-1 equine population in the State of São Paulo, however the occurrence of infection with EHV-4 is not registered. Due to the antigenic similarity between the two virus types, the differential serodiagnosis by traditional methods such as neutralization and complement fixation reaction, it is not possible. Thus, this study evaluated the first time in São Paulo, through an indirect ELISA employing a region of glycoprotein G to differentiate EHV-1 EHV-4 (iELISAgG), the presence of specific antibodies to the two types of equine herpesvirus in 512 animals from 20 municipalities in 8 regions the State of São Paulo, among horses, mules and donkeys of both sexes, different age groups, vaccinated and unvaccinated. The same samples were tested for EHV through the neutralization test, traditionally used for the detection of antibodies against the virus. The results obtained with the neutralization revealed 205/512 (40.03%) seropositive animals. By ELISA we obtained 3/512 (0.59%) animals positive for EHV-1, 347/512 (67.77%) animals positive for EHV-4 and 108/512 (21.09% ) animals positive for both. The group of unvaccinated animals showed 127/352 (36.07%) HIV-positive by serum neutralization test, while 4/352 (1.14%) were positive for EHV-1, 237/352 (67.33%) were positive for EHV-4 and 69/352 (19.6%) were positive for both ELISA. The group of vaccinated animals showed 78/160 (48.75%) seropositive by neutralization test, while 1 / 160 (0.63%) were positive for EHV-1, 112/160 (70%) were positive for EHV-4 and 37/160 (23.13%) were positive for both ELISA. The results suggest low circulation of EHV-1 and high circulation of EHV-4 according to the results found in unvaccinated animals. The correlation analysis between the two tests employed showed poor agreement
Fritsche, Ann-Kathrin [Verfasser]. "Virological and molecular biological characterization of Equid Herpesvirus 1 (EHV-1) isolates from Germany / Ann-Kathrin Fritsche." Berlin : Freie Universität Berlin, 2015. http://d-nb.info/1078017506/34.
Picard, J. A. "Respiratory pathogens in thoroughbred foals up to one year of age on a stud farm in South Africa." Diss., University of Pretoria, 2005. http://hdl.handle.net/2263/22867.
Dissertation (MSc (Veterinary Science))--University of Pretoria, 2005.
Veterinary Tropical Diseases
unrestricted
Carvalho, Rodrigo Franco. "Caracterização genomica de isolados brasileiros do herpesvirus equino do tipo 1." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316620.
Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia
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Resumo: O herpesvírus eqüino do tipo 1 (EHV-1) é um membro da subfamília Alfaherpesvirinae, implicado no surgimento de distúrbios respiratórios, reprodutivos e nervosos em cavalos. A principal forma de contaminação dos animais é através do contato direto com secreções contaminadas pelo vírus. No eqüino, a disseminação do vírus ocorre pela transposição da infecção respiratória a outros órgãos e sistemas através da corrente sanguínea. Pouco se sabe sobre a ocorrência do EHV-1 no Brasil. Dessa forma, este estudo teve por objetivo o isolamento do EHV-1 a partir de material biológico e produção e análise de dados moleculares de isolados brasileiros de EHV-1. Durante este estudo, foi realizado o isolamento de uma amostra de EHV-1 a partir da inoculação de material clínico em células de derme eqüina (ED). Este isolado foi diagnosticado como EHV-1 através da reação em cadeia da polimerase (PCR) para o gene da timidina quinase (tk). Neste trabalho, foram também realizados os seqüenciamentos de fragmentos de PCR derivados do isolado aqui descrito, de uma outra amostra brasileira de EHV-1 e de duas amostras estrangeiras do vírus para análise filogenética. A análise comparativa entre seqüências permitiu inferências sobre o nível de divergência entre os vírus estudados, além da listagem de seqüências regulatórias para atividade gênica em um sítio do genoma localizado próximo ao gene tk. Na região genômica reportada foram contextualizadas ao menos três genes (ORF 38, ORF 37 e ORF 36). Os dados levantados com o seqüenciamento de amostras de EHV-1 de origens geográficas distintas (Brasil, Europa e América do Norte) não mostraram divergências, o que pode estar associado a um processo seletivo constritivo, que impediria a fixação de novas mutações naquela região. A ausência de divergências também pode estar associada à importância dessa região na regulação gênica do EHV-1. Também é um indicativo para a fidelidade dos mecanismos de replicação envolvidos na síntese do DNA viral, o que sugere a importância da região estudada na regulação da expressão gênica do EHV-1
Abstract: Equine Herpesvirus Type 1 (EHV-1) is a member of Alphaherpesvirinae subfamily implicated with abortions, respiratory and neurological disturbs in horses. The principal mode of viral transmission is through close contact virus-containing secretions of infected horses. Systemic pathogenesis in which this virus is implicated combines primary respiratory infection and spread of viral particles through the circulatory/lymphatic system. Until today, there are only few studies involving the isolation of this virus in Brazil. Thus, the main goal of this study was the isolation of EHV-1 from biological material and the production and analysis of molecular data derived from Brazilian EHV-1 isolates. Clinical samples were screened by inoculation into Equine Dermis (ED) cells monolayers, searching for the characteristic citopathic effect produced by EHV-1. Inoculation of one tissue sample has presented a suggestive citopathic effect. Re-inoculation of the original tissue homogenate in a second, independent experiment reproduced the same positive result. Following these observations, infection agent diagnostic was done by PCR for thymidine kinase (tk) gene. The results demonstrated that sample was EHV-1 positive. In this work, it was done either the sequencing of PCR fragments derived from two Brazilian and two foreign samples of EHV-1 for filogenetic and genomic analyses purposes. It was assigned at least three Open Reading Frames contexts (ORF 38, ORF 37, ORF 36). The data do not show genetic variation between sequences. The high level of genetic conservation for this region, despite the distinct geographic origins (Brazil, Europe and North America) of EHV-1 samples studied, indicates a strong selection process against the fixation of new mutations. It also highlights a high level of fidelity for DNA replication and strongly suggests the importance of the studied region for EHV-1 gene regulation
Doutorado
Microbiologia
Doutor em Genetica e Biologia Molecular
Seeber, Peter Andreas [Verfasser]. "Equid herpesvirus infections in zebras (Equus sp.): host physiology and non-invasive detection of virus shedding / Peter Andreas Seeber." Berlin : Freie Universität Berlin, 2019. http://d-nb.info/1177152622/34.
Dunuwille, Saranajith Wangisa. "MODULATION OF INFLAMMATORY CYTOKINE, CHEMOKINE, AND TOLL-LIKE RECEPTOR GENES AND TRANSCRIPTOME ANALYSIS OF EQUINE ENDOTHELIAL CELLS FOLLOWING INFECTION WITH EQUID HERPESVIRUS-1, AND EQUINE ARTERITIS VIRUS." UKnowledge, 2019. https://uknowledge.uky.edu/gluck_etds/44.
Gießler, Kim [Verfasser], and Lutz [Akademischer Betreuer] Göhring. "Characterizing viral distribution, viral load and cell tropism during early latent Equid Herpesvirus 1 (EHV-1) infection: novel insights into EHV-1 latency pathogenesis / Kim Gießler ; Betreuer: Lutz Göhring." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2021. http://d-nb.info/1230754776/34.
Thieulent, Côme. "Criblage in vitro de molécules antivirales contre l'herpèsvirus équin-1 par impédancemétrie et évaluation clinique de l'effet du valganciclovir Screening and evaluation of antiviral compounds against Equid alpha-herpesviruses using an impedance-based cellular assay Identification of antiviral compounds against equid herpesvirus-1 using real-time cell assay screening: Efficacy of decitabine and valganciclovir alone or in combination Screening of potential antiviral molecules against equid herpesvirus-1 using cellular impedance measurement: dataset of 2,891 compounds New EHV-1 variant identified | Veterinary Recordvir réduit les signes cliniques, l'excrétion virale et la virémie chez des poneys infectés expérimentalement par la nouvelle souche C2254 d'herpèsvirus équin 1 Oral administration of valganciclovir reduces clinical signs, virus sheedind and cell-associated viremia in ponies experimentally infected with the new variant C2254 of equid herpesvirus-1." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMC421.
Nine herpesviruses are known to infect the equine population. Among them, the equid herpesvirus 1 (EHV-1) induces the most severe forms of diseases. Indeed, this virus causes respiratory symptoms, abortions, neonatal foal deaths and nervous diseases, often leading to their euthanasia. Prophylaxis, relying on good sanitary practices and vaccination remains the best way to avoid epizooties of herpesviruses. Vaccines reducing efficiently respiratory disorders and EHV-1 dissemination are currently available. However, they do not prevent abortions and have no proven effect against nervous symptoms. In addition, the vaccine coverage is insufficient in France. Antiviral therapy is therefore an interesting complementary approach in the fight against EHV-1. However, there is a lack of studies evaluating the antiviral effect of compounds against EHV-1, limiting the prospects of use. To resolve this issue, we have developed a medium/high throughput screening protocol using the RTCA xCELLigence® technology based on cell impedance measurements. Following the screening of 2891 compounds, 21 candidates were identified for their efficacy against EHV-1. Among them, aphidicolin, decitabine, ganciclovir, idoxuridine, pritelivir and valganciclovir showed the best efficacy. The activity of these compounds was confirmed on different cell lines in the presence of different EHV-1 strains. This study led to the identification and the understanding of the mode of action of decitabine. This deoxycitidine analogue, also showed a synergistic effect when combined with valganciclovir. In the second part of this work, we evaluated the effect of valganciclovir treatment during an experimental infection by nebulisation with a new EHV-1 strain (C2254) recently isolated during the epizootic of 2018. This study demonstrated that a dose of 6.5 mg/kg body weight of valganciclovir, administrated orally twice a day, allowed to maintain a good protection prior the establishment of the humoral immune response. Indeed, this treatment allows to reduce significantly clinical signs, viral excretion and cell-associated viremia induced by EHV-1 on ponies. This work carried out in vivo demonstrated the efficiency of valganciclovir treatment against EHV-1, while the in vitro screening opens up new perspectives of treatment, in particular with compounds association
Carnet, Flora. "Amélioration des protocoles vaccinaux contre la grippe équine et la rhinopneumonie : apport de l’iPPVO en tant qu’adjuvant dans le modèle équin, nouvelle approche de la mesure des anticorps neutralisants." Electronic Thesis or Diss., Normandie, 2023. http://www.theses.fr/2023NORMC413.
Equine influenza virus (EIV) and equine herpesvirus-1 (EHV-1) are frequently described in many countries and are two endemic pathogens in the French equine population. These infectious diseases have important consequences both in terms of animal health and welfare and in terms of economic impact. The fight against these viruses is essentially based on the implementation of preventive measures such as vaccination. Despite this epizootics of EIV and EHV-1 are regularly declared in France and throughout the world. Neutralising antibodies, synthesised in response to infection or after immunisation, represent the main line of defence against these viruses. Improved vaccines and a wider range of tools to measure neutralising antibodies can be a valuable strategy in the fight against these viruses. In order to improve the efficacy of the vaccine response, both in magnitude and duration, the use of adjuvants is one way to improve immunogenicity. This thesis consisted, in the first instance, in establishing the proof of concept of the use of iPPVO as an innovative adjuvant in vivo in horses in the context of vaccination against EIV. For this purpose, antibodies were measured by SRH, a method for which the correlates of protection are well defined. The addition of iPPVO at vaccination significantly increased the antibody level to EIV and protection in horses up to 6 months after immunisation. In a second step, a new method for measuring EIV antibodies in serum based on impedancemetry was developed to improve on current methods and facilitate high throughput analysis. This neutralisation test correlated well with SRH test. Another study was performed, which demonstrated the adjuvant potential of iPPVO in horses during vaccination against EHV-1,4. The antibody response measured by serum neutralisation increased up to 5 months after immunisation. Finally, preliminary results on the mechanism of action of iPPVO on peripheral blood mononuclear cells demonstrated the importance of the interferon
Welch, Hazel Mary. "Latency of the Equid herpesviruses 1 and 4." Thesis, Royal Veterinary College (University of London), 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.519553.
O'Neill, Terry. "T lymphocyte responses to equid herpesviruses 1 and 4 in horses." Thesis, Open University, 1995. http://oro.open.ac.uk/57557/.