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Journal articles on the topic 'Eprinomectine'

Author: Grafiati
Published: 25 January 2025
Last updated: 31 July 2025

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1

Ali, M. Sher, Tung Sun, Gina E. McLeroy, and Evan T. Phillippo. "Simultaneous Determination of Eprinomectin, Moxidectin, Abamectin, Doramectin, and Ivermectin in Beef Liver by LC with Fluorescence Detection." Journal of AOAC INTERNATIONAL 83, no. 1 (2000): 31–38. http://dx.doi.org/10.1093/jaoac/83.1.31.

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Abstract Eprinomectin, moxidectin, abamectin, doramectin, and ivermectin are drugs used to control parasitic infections in both meat-producing and nonmeat-producing animals. A number of analytical methods are available to analyze these anthelmintic drugs individually. A multiresidue screening method was developed for these drugs; however, the initial attempt to derivatize eprinomectin following the method published by Merck scientists was unsuccessful because the eprinomectin derivatization reaction was temperature- and time-dependent. The optimum time and temperature for the completion of epr
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2

ANASTASIO, ANIELLO, VINCENZO VENEZIANO, EMILIANA CAPURRO, et al. "Fate of Eprinomectin in Goat Milk and Cheeses with Different Ripening Times following Pour-On Administration." Journal of Food Protection 68, no. 5 (2005): 1097–101. http://dx.doi.org/10.4315/0362-028x-68.5.1097.

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The distribution of eprinomectin in goat milk and cheeses (cacioricotta, caciotta, caprilisco) with different ripening times following a pour-on administration at a single dose rate (500 μg/kg of body weight) and a double dose rate (1,000 μg/kg of body weight) to goats with naturally occurring infections of gastrointestinal nematodes was studied. Milk residues of eprinomectin reached a maximum of 0.55 ± 0.18 μg/kg and 1.70 ± 0.31 μg/kg at the single and double doses, respectively. The drug concentrations decreased progressively until the fifth day after treatment, when they were less than the
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3

Arsenopoulos, Konstantinos V., Eleni Michalopoulou, and Elias Papadopoulos. "Comparing Short Versus Long Persistency of Anthelmintics: Impacts on Dairy Sheep Production." Animals 15, no. 7 (2025): 1028. https://doi.org/10.3390/ani15071028.

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Introduction: Grazing dairy ewes are often heavily challenged by parasitic infections, which represent one of the most important concerns in sheep farming due to their impacts on dairy sheep production. Objectives: The objectives of the present study were (i) to compare the short (i.e., albendazole) and long (i.e., eprinomectin) persistent effect of these anthelmintics in reducing infections by gastrointestinal nematodes (GIN) in ewes and (ii) to determine these effects on milk yield and quality in naturally infected with GIN dairy ewes. Methods: On each farm, 40 selected ewes were divided int
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4

Yazwinski, T. A., E. G. Johnson, D. R. Thompson, et al. "Nematocidal efficacy of eprinomectin, delivered topically, in naturally infected cattle." American Journal of Veterinary Research 58, no. 6 (1997): 612–14. http://dx.doi.org/10.2460/ajvr.1997.58.06.612.

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Abstract Objective To assess the nematocidal efficacy of eprinomectin in naturally infected cattle. Animals 62 (31 eprinomectin-treated and 31 control) beef mixed-breed or Holstein cattle, either 6 to 11 or 48 to 96 months old. Procedure Cattle were housed 21 to 27 days before treatment to allow parasites to reach maturity. Animals were grouped by sex, ranked by weight, and randomly assigned to treatment group. Fecal flotation was done to identify cattle with intestinal nematode infections. Treatment groups were: 1—eprinomectin topical vehicle (1 ml/10 kg) and 2—eprinomectin topical solution (
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5

Durden, David A., and Janice Wotske. "Quantitation and Validation of Macrolide Endectocides in Raw Milk by Negative Ion Electrospray MS/MS." Journal of AOAC INTERNATIONAL 92, no. 2 (2009): 580–96. http://dx.doi.org/10.1093/jaoac/92.2.580.

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Abstract Macrolide endectocides (abamectin, doramectin, emamectin, eprinomectin, ivermectin, and moxidectin) are used to treat animals against a variety of parasites. They are approved for use with food animals, but require long withdrawal times. Two compounds, eprinomectin and moxidectin, are approved for use with lactating cattle and have established maximum residue limit values of 20 and 40 g/kg, respectively. The remaining compounds may appear in milk if there is off-label or accidental use. This method is capable of quantitating and confirming the presence of six of the macrolide endectoc
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6

Holste, J. E., D. D. Colwell, R. Kumar, et al. "Efficacy of eprinomectin against Hypoderma spp in cattle." American Journal of Veterinary Research 59, no. 1 (1998): 56–58. http://dx.doi.org/10.2460/ajvr.1998.59.01.56.

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SUMMARY Objective To determine the efficacy of a topical formulation of eprinomectin against natural infestations of first (L1)-stage, and second and third (L2/L3)-stage larvae of Hypoderma spp. Animals 140 approximately 6- to 18-month-old cattle of various breeds. Procedure Cattle, selected from herds with high prevalence of Hypoderma infestation, were treated in 4 experiments: within each replicate, 1 animal received eprinomectin at a dosage of 500 μg/kg of body weight against first-stage larvae (L1). The second animal received the same treatment against second or third-stage larvae (L2/L3).
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7

Kırcalı Sevimli, F., E. Kozan, and N. Doğan. "Efficacy of eprinomectin pour-on treatment in sheep naturally infected with Dictyocaulus filaria and Cystocaulus ocreatus." Journal of Helminthology 85, no. 4 (2011): 472–75. http://dx.doi.org/10.1017/s0022149x10000854.

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AbstractThe efficacy of eprinomectin on Dictyocaulus filaria and Cystocaulus ocreatus in naturally infected sheep was evaluated in the present study. In total, 30 infected sheep were randomly divided into two groups: treated (n = 15) and untreated (n = 15). A single pour-on dose of eprinomectin (0.5 mg/kg) was administered to the treated group. No medication was used in the untreated group. Faecal larval counts were performed on pre-treatment (day 0) and post-treatment (days 7, 14, 21 and 42) days. Eprinomectin was found to be 100% effective against D. filaria on day 7 post-treatment when comp
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8

Hou, Xiaolin, Haiyang Jiang, Shuangyang Ding, Suxia Zhang, Xiaowei Li, and Jianzhong Shen. "Multiresidue Analysis of Avermectins in Cattle Liver by Liquid Chromatography/Tandem Mass Spectrometry." Journal of AOAC INTERNATIONAL 89, no. 4 (2006): 1110–15. http://dx.doi.org/10.1093/jaoac/89.4.1110.

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Abstract A simple multiresidue analysis method was developed for the confirmation and quantification of eprinomectin, abamectin, doramectin, and ivermectin in cattle liver. The target analytes were extracted with acetonitrile and cleaned up with C18 and C8 solid-phase extraction cartridges before analysis by liquid chromatography combined with positive ion electrospray tandem mass spectrometry. The residue mean recoveries of the 4 drugs were 64.1699.53%. The limit of detection was 2.5 ng/g for eprinomectin, abamectin, doramectin, and ivermectin.
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9

Jacquot, Virginie, Prescillia Buellet, Laura Letendre, Wei Tong, Henry Li, and Eric Tielemans. "Pharmacokinetics of a novel endectoparasiticide topical formulation for cats, combining esafoxolaner, eprinomectin and praziquantel." Parasite 28 (2021): 19. http://dx.doi.org/10.1051/parasite/2021014.

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Esafoxolaner, a purified enantiomer of afoxolaner with insecticidal and acaricidal properties, is combined with eprinomectin and praziquantel in NexGard®Combo, a novel topical endectoparasiticide formulation for cats. The parasiticide potencies of topical esafoxolaner, eprinomectin and praziquantel, are based on transcutaneous absorption, systemic distribution, and exposure of respective target parasites. For each compound, the pharmacokinetic profile, non-interference, dose linearity/proportionality after one administration, and the accumulation and time to reach a steady state after repeated
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10

Floate, K. D., D. D. Colwell, and A. S. Fox. "Reductions of non-pest insects in dung of cattle treated with endectocides: a comparison of four products." Bulletin of Entomological Research 92, no. 6 (2002): 471–81. http://dx.doi.org/10.1079/ber2002201.

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AbstractPour-on formulations of four endectocide products were compared to assess the effect of faecal residues on insects developing in naturally-colonized dung of treated cattle. In each of three independent experiments, suppression of insects was associated with application of doramectin, eprinomectin and ivermectin, but no effect was observed for moxidectin. When data were combined across experiments to increase sample sizes, suppression of insects was observed for each compound, with the least effect being observed for moxidectin. Based on the number of species affected and duration of su
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11

Sheridan, Robert, and Lucille Desjardins. "Determination of Abamectin, Doramectin, Emamectin, Eprinomectin, Ivermectin, and Moxidectin in Milk by Liquid Chromatography Electrospray Tandem Mass Specrometry." Journal of AOAC INTERNATIONAL 89, no. 4 (2006): 1088–94. http://dx.doi.org/10.1093/jaoac/89.4.1088.

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Abstract The avermectin and milbemycin families of compounds are derived from naturally occurring yeasts. They have proven to be potent preventatives against a variety of pests such as insects and parasites. Only eprinomectin and moxidectin are currently approved for use on lactating cattle with tolerances in milk of 12 μg/kg for eprinomectin and 40 μg/kg for moxidectin. Detection of misuse or inadvertent contamination in milk requires a sensitive and definitive analytical method. A method has been developed for the determination of 5 avermectins and 1 milbemycin in milk using a simple liquidl
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12

Barth, Dietrich, Jakie A. Hair, Bruce N. Kunkle, et al. "Efficacy of eprinomectin against mange mites in cattle." American Journal of Veterinary Research 58, no. 11 (1997): 1257–59. http://dx.doi.org/10.2460/ajvr.1997.58.11.1257.

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SUMMARY Objective To determine whether eprinomectin was effective against mange caused by Chorioptes bovis and Sarcoptes bovis in cattle. Animals 80 cows naturally infested with C bovis and 30 cattle experimentally infested with S bovis. Procedure 6 trials were performed to determine efficacy against C bovis, and 2 trials were performed to determine efficacy against S bovis. In each trial, a group of untreated animals or of animals treated with vehicle alone was compared with a group of animals treated with a 0.5% formulation of eprinomectin applied topically (500 μg/kg). Number of mites in sk
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13

Gerunov, Taras, Lyudmila Gerunova, Valentina Pleshakova, Ekaterina Ivanova, Yana Kryuchek, and Natal'ya Zolotova. "EFFECTS OF MYCOTOXIN-CONTAMINATED FEED AND ANTIPARASITIC TREATMENT WITH EPRINOMECTIN ON THE INTESTINAL MICROBIOTA OF ANIMALS UNDER EXPERIMENTAL CONDITIONSEFFECTS OF MYCOTOXIN-CONTAMINATED FEED AND ANTIPARASITIC TREATMENT WITH EPRINOMECTIN ON THE INTESTINAL MICROBIOTA OF ANIMALS UNDER EXPERIMENTAL CONDITIONS." Bulletin of KSAU, no. 12 (January 27, 2025): 207–14. https://doi.org/10.36718/1819-4036-2023-12-207-214.

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Animals are exposed to numerous stress factors in industrial conditions. The greatest danger is posed by mycotoxins that change the composition of the microbiota in animals, which is one of the reasons for the development of immunosuppression. The purpose of the study is to establish changes in the composition of the intestinal microbiota in laboratory animals with combined contamination of feed with mycotoxins and antiparasitic treatment with eprinomectin. The study was conducted on laboratory rats (five groups of 10 rats each). Animals of the 1st group received a standardized diet and were n
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14

Williams, J. C., J. A. Stuedemann, K. Bairden, et al. "Efficacy of a pour-on formulation of eprinomectin (MK-397) against nematode parasites of cattle, with emphasis on inhibited early fourth-stage larvae of Ostertagia spp." American Journal of Veterinary Research 58, no. 4 (1997): 379–83. http://dx.doi.org/10.2460/ajvr.1997.58.04.379.

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Abstract Objective To evaluate efficacy of topically applied eprinomectin against inhibited early fourth-stage larvae (IL4) of Ostertagia spp in calves. Animals 4 groups (n = 6 [replicates]) for dose titration; 2 groups (n = 8 calves [replicates]) for dose confirmation. Procedure 2 dose titration studies—0, 125, 250, and 500 μg of eprinomectin/kg of body weight—Louisiana and Georgia—and 2 dose confirmation studies of selected therapeutic dosage (500 μg/kg) in Scotland and France. Monitor calves were used to determine inhibition percentage of Ostertagia IL4. Test calves were ranked by weight in
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15

Prelezov, P., N. Nizamov, and P. Veleva. "Tests on the efficacy of amitraz, ivermectin and eprinomectin for control of lice in goats." BULGARIAN JOURNAL OF VETERINARY MEDICINE 25, no. 3 (2022): 492–99. http://dx.doi.org/10.15547/bjvm.2358.

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Ectoparasitic infestations with Linognathus stenopsis and Bovicola caprae are a serious concern in goat farms, especially during the winter and spring. This study tested the efficacy of three modern insecticide drugs (ivermectin, eprinomectin and amitraz) applied via different routes for control of sucking and chewing lice in naturally co-infected goats. Each of drugs was tested on 30 goats. The animals from the first flock were treated with a single dose of ivermectin, applied subcutaneously at 0.2 mg/kg, the second one received a single spot on treatment with 1 mg/kg еprinomectin and the thi
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16

Dadé, Martín, Martín Daniele, and Nora Mestorino. "Evaluation of the toxic effects of doramectin, ivermectin and eprinomectin against Triatoma infestans using a rat model." Biomédica 37, no. 3 (2017): 324. http://dx.doi.org/10.7705/biomedica.v37i3.3316.

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Introducción. La principal herramienta para el control de los triatominos, vectores de Trypanosoma cruzi, ha sido el uso masivo e intensivo de piretroides. La aparición de resistencia a estas moléculas ha planteado la necesidad de encontrar estrategias nuevas, alternativas y complementarias de control.Objetivo. Evaluar el efecto tóxico de la ivermectina, la doramectina y la eprinomectina sobre Triatoma infestans y sus consecuencias en la alimentación con sangre en un modelo de roedor.Materiales y métodos. Se alimentaron ninfas de quinto estadio de T. infestans en distintos momentos sobre ratas
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17

Rambozzi, Luisa, Luca Rossi, Anna Rita Molinar Min, et al. "Efficacy and safety of topical eprinomectin to controlMyocoptes musculinus infestation in mice." Revista Brasileira de Parasitologia Veterinária 23, no. 2 (2014): 244–47. http://dx.doi.org/10.1590/s1984-29612014024.

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Myocoptes musculinus is the most common fur mite identified among laboratory mice; infested mice, in addition to dermatological signs, may also be prone to secondary infections, affecting the outcome of a research trial. This trial was conducted in order to assess the safety and efficacy of a single topical administration of eprinomectin (5mg/kg BW) in a naturally infested laboratory mice colony. A safety trial was conducted on 20 uninfested pregnant females assigned to two groups, receiving eprinomectin and mineral oil, respectively. The mice were examined daily for signs of illness or toxici
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18

Landers, Sophia F., Christopher Tucker, Jeremy G. Powell, Eva Wray, Reagan Cauble, and Toby D. Lester. "122 The efficacy of extended-release eprinomectin for the reduction of horn flies, face flies, and fecal egg counts of parasitic nematodes in replacement beef heifers." Journal of Animal Science 97, Supplement_1 (2019): 53. http://dx.doi.org/10.1093/jas/skz053.119.

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Abstract The purpose of this study was to evaluate the efficacy of extended-release eprinomectin against horn flies, face flies, and fecal egg counts of parasitic nematodes in crossbreed replacement beef heifers. Fifty-four heifers were randomly placed into three treatment groups (n = 18 heifers/treatment). Group 1 was administered the labeled dosage of extended-release eprinomectin at the onset of fly season (day 0). Group 2 acted as the negative control. Group 3 received the anthelmintic injection once a quarter of the heifers in the group reached the threshold treatment level for horn flies
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Landers, Sophia F., Christopher Tucker, Jeremy G. Powell, Eva Wray, Reagan Cauble, and Toby D. Lester. "56 The efficacy of extended-release eprinomectin for the reduction of horn flies, face flies, and fecal egg counts of parasitic nematodes in replacement beef heifers." Journal of Animal Science 97, Supplement_1 (2019): 81–82. http://dx.doi.org/10.1093/jas/skz053.185.

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Abstract The purpose of this study was to evaluate the efficacy of extended-release eprinomectin against horn flies, face flies, and fecal egg counts of parasitic nematodes in crossbreed replacement beef heifers. Fifty-four heifers were randomly placed into three treatment groups (n = 18 heifers/treatment). Group 1 was administered the labeled dosage of extended-release eprinomectin at the onset of fly season (day 0). Group 2 acted as the negative control. Group 3 received the anthelmintic injection once a quarter of the heifers in the group reached the threshold treatment level for horn flies
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20

Knaus, Martin, Christine Baker, Roberto Alva, et al. "Efficacy of a novel topical combination of esafoxolaner, eprinomectin and praziquantel in cats againstToxocara catiandDipylidium caninum." Parasite 28 (2021): 28. http://dx.doi.org/10.1051/parasite/2021024.

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NexGard®Combo, a novel topical antiparasitic product for cats, combines the insecticide/acaricide esafoxolaner with the nematocide eprinomectin and cestodicide praziquantel. The efficacy of this combination product was evaluated against two common endoparasites of global occurrence in cats, the nematodeToxocara catiand the cestodeDipylidium caninum, in five controlled studies using naturally or experimentally infected cats with parasites of North American, South African or European origin. Cats evaluated in these studies harbored patent infection of the target parasite confirmed through a pre-
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21

Ishikawa, I., and M. Iwasa. "Effects of eprinomectin on the survival, reproduction and feeding activity of the dung beetles, Onthophagus lenzii Harold, and rare species, Copris ochus Motschulsky (Coleoptera: Scarabaeidae)." Bulletin of Entomological Research 109, no. 2 (2018): 191–98. http://dx.doi.org/10.1017/s0007485318000317.

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AbstractEffects of the antiparasitic drug eprinomectin were studied on the dung beetles, Onthophagus lenzii Harold and the rare species, Copris ochus Motschulsky by pour-on administrations (500 µg kg−1) in Japan. Eprinomectin was detected in cattle dung from 1 to 7 or 14 days after treatment, with a peak at 1 day after treatment in two experiments. In O. lenzii, adult survivals and numbers of brood balls constructed were significantly reduced in dung from eprinomectin-treated cattle at 1 and 3 days post-treatment in experiment 1, and adult emergence rates were extremely reduced in dung at 1, 3
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22

Rambozzi, Luisa, Pier Giuseppe Meneguz, Anna Rita Molinar Min, Mario Pasquetti, and Andrea Peano. "Concurrent Chorioptic Mange and Dermatophytosis in Dairy Goats: A Case Report." Veterinary Sciences 9, no. 12 (2022): 677. http://dx.doi.org/10.3390/vetsci9120677.

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A concurrent chorioptic mange and dermatophytosis outbreak occurred in a goat flock in northwestern Italy. Sanitation of the flock was obtained following pour-on eprinomectin application at a dose of 1 mg/kg; enilconazole was used for environmental disinfection against dermatophyte spores.
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Ali, M. Sher, Tung Sun, Gina E. McLeroy, and Evan T. Phillippo. "Confirmation of Eprinomectin, Moxidectin, Abamectin, Doramectin, and Ivermectin in Beef Liver by Liquid Chromatography/Positive Ion Atmospheric Pressure Chemical Ionization Mass Spectrometry." Journal of AOAC INTERNATIONAL 83, no. 1 (2000): 39–52. http://dx.doi.org/10.1093/jaoac/83.1.39.

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Abstract A liquid chromatographic (LC) multiresidue screening procedure was developed for determination of eprinomectin, moxidectin, abamectin, doramectin, and ivermectin in beef liver at 0, 25, 50, and 100 ppb levels. A procedure using low resolution LC/atmospheric pressure chemical ionization (APCI) mass spectrometry (MS) was developed with further purification steps added to the quantitative LC method to confirm residues. Acetonitrile extracts of liver, prior to derivatization for LC analysis, were further purified by using a C8 solid-phase extraction cartridge and an alumina-B cartridge. T
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Volk, Mareah J., Taylor R. Krause, Rebecca S. Stokes, Frank A. Ireland, and Daniel W. Shike. "Effects of extended-release eprinomectin on fescue toxicosis, performance, and reproduction on fall-calving beef cows." Translational Animal Science 3, no. 4 (2019): 1423–34. http://dx.doi.org/10.1093/tas/txz093.

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Abstract The objective of this experiment was to evaluate effects of extended-release eprinomectin on fescue toxicosis and impacts on performance and reproduction in fall-calving beef cows. Fall-calving Angus × Simmental multiparous cows [n = 335; age = 5.8 ± 2.1 yr; 586.5 ± 6.0 kg body weight (BW); 5.48 ± 0.05 body condition score (BCS)] were stratified by BW, age, and BCS and randomly assigned to one of three treatments. Treatments included a spring injection of extended-release eprinomectin (SERE) on day 0, a fall injection of extended-release eprinomectin injection (FERE) on day 84, and a
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Zeng, Zhaopie, and Nicholas W. Andrew. "Characterization of Eprinomectin N-Deacetylase in Rats." Drug Metabolism and Disposition 27, no. 2 (1999): 269–73. https://doi.org/10.1016/s0090-9556(24)15289-0.

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Halley, Bruce A., Renate Winter, Stephen Yoon, S. E. Marley, and Steffen Rehbein. "The environmental safety of eprinomectin to earthworms." Veterinary Parasitology 128, no. 1-2 (2005): 109–14. http://dx.doi.org/10.1016/j.vetpar.2004.11.007.

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A., Lespine, Sutra J., Dupuy J., and Alvinerie M. "Eprinomectin in goat: assessment of subcutaneous administration." Parasitology Research 89, no. 2 (2003): 120–22. http://dx.doi.org/10.1007/s00436-002-0727-z.

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da Silva, A. D., A. S. da Silva, M. D. Baldissera, et al. "Oxidative stress in dairy cows naturally infected with the lungworm Dictyocaulus viviparus (Nematoda: Trichostrongyloidea)." Journal of Helminthology 91, no. 4 (2016): 462–69. http://dx.doi.org/10.1017/s0022149x16000456.

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AbstractThe aim of this study was to analyse the oxidative and anti-oxidant status in serum samples from dairy cows naturally infected by Dictyocaulus viviparus and its relation with pathological analyses. The diagnosis of the disease was confirmed by necropsy of one dairy cow with heavy infection by the parasite in the lungs and bronchi. Later, blood and faeces were collected from another 22 cows from the same farm to measure reactive oxygen species (ROS) levels, thiobarbituric acid-reactive substances (TBARS), catalase (CAT) and superoxide dismutase (SOD) activities on day 0 (pre-treatment)
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Dawson, Cody R., Mareah J. Volk, Frank A. Ireland, Keela M. Trennepohl, Joshua C. McCann, and Daniel W. Shike. "371 Evaluation of parasite resistance in cattle treated with extended-release eprinomectin (LongRange)." Journal of Animal Science 97, Supplement_2 (2019): 156. http://dx.doi.org/10.1093/jas/skz122.276.

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Abstract The objective was to determine parasite resistance in cattle treated with extended-release eprinomectin (LongRange) from a herd with 3 years of prior eprinomectin use. Fall-born Angus x Simmental heifers (224 ± 22 d of age) were randomly assigned 1 of 3 treatments: LongRange (LR; n = 21), LongRange and Synanthic (COMBO; n = 21), or saline-treated control (CON; n = 21). At trial initiation, all heifers were administered treatments according to label instructions. All heifers grazed endophyte-infected tall fescue in groups (n = 3 per treatment) and supplemented daily modified wet distil
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Uczay, Fernanda, Nelson M. G. Bandeira, Luana Floriano, Osmar D. Prestes, Martha B. Adaime, and Renato Zanella. "Determination of Avermectins Residues in Soybean, Bean, and Maize Using a QuEChERS-Based Method and Ultra-High-Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry." Separations 8, no. 11 (2021): 214. http://dx.doi.org/10.3390/separations8110214.

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Soybean, maize, and bean are crops of great economic importance, but in recent years have suffered with infestations of the caterpillar Helicoverpa armigera, with the main reason being the resistance of this pest to most pesticides. Avermectin emamectin benzoate was recently released to control this pest. Other avermectins, like abamectin, doramectin, eprinomectin, and ivermectin are used in large scale because they potent acaricidal, anthelmintic, and insecticidal activities. Thus, a simple and fast method for the determination of avermectins in these crops based on a quick, easy, cheap, effe
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Mihalca, Andrei Daniel, Georgiana Deak, Luciana Cătălina Panait, Ştefan Rabei, and Frederic Beugnet. "Efficacy of a topical formulation containing esafoxolaner, eprinomectin and praziquantel (NexGard Combo ) against natural infestations with the cat louse, Felicola subrostratus under field conditions." Parasite 29, no. 62 (2022): 1–6. https://doi.org/10.1051/parasite/2022062.

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Mihalca, Andrei Daniel, Deak, Georgiana, Panait, Luciana Cătălina, Rabei, Ştefan, Beugnet, Frederic (2022): Efficacy of a topical formulation containing esafoxolaner, eprinomectin and praziquantel (NexGard Combo ) against natural infestations with the cat louse, Felicola subrostratus under field conditions. Parasite (Paris, France) 29 (62): 1-6, DOI: 10.1051/parasite/2022062, URL: http://dx.doi.org/10.1051/parasite/2022062
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Gang, Qiu, and Rui Yapei. "Preparation of Eprinomectin Nanoemulsions and Determination of Their Pharmacokinetics and Pharmacodynamics in Dairy Cows." Journal of Biomedical Nanotechnology 18, no. 2 (2022): 512–26. http://dx.doi.org/10.1166/jbn.2022.3268.

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This study aimed to develop an anthelmintic that leaves no residues and is safe and efficient for use in cows. We constructed classical pseudoternary phase diagrams using experimental animal data to optimize and characterize the eprinomectin nanoemulsion formulas. The emulsion samples prepared with ethyl acetate, polysorbate 80, and 1-propanediol as the main components were transparent and uniform when observed under a Hitachi transmission electron microscope (TEM) system. A Mastersizer 3000 laser particle size analyzer was used to determine the particle sizes of the prepared nanoemulsions. Th
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Zanzani, Sergio Aurelio, Alessia Libera Gazzonis, Emanuela Olivieri, Luca Villa, Cristina Fraquelli, and Maria Teresa Manfredi. "Gastrointestinal nematodes of goats: host–parasite relationship differences in breeds at summer mountain pasture in northern Italy." Journal of Veterinary Research 63, no. 4 (2019): 519–26. http://dx.doi.org/10.2478/jvetres-2019-0076.

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AbstractIntroductionThe Orobic goat is a hardy breed native to the Orobic Alps (Lombardy, northern Italy). The aim of the study was the assessment of gastrointestinal nematode (GIN) egg excretion in Alpine and Saanen (cosmopolite breeds) and Orobic grazing goats, after a strategic treatment with eprinomectin in late June.Material and MethodsIndividual faecal samples from a mixed flock of cosmopolite and Orobic goats were collected and analysed by the FLOTAC double technique every three weeks from June to September.ResultsStrongylida was the primary GIN infection observed in goats that grazed o
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Arece-García, J., Y. López-Leyva, A. Olmedo-Juárez, et al. "First report of multiple anthelmintic resistance in goat farm in Cuba." Helminthologia 54, no. 4 (2017): 358–62. http://dx.doi.org/10.1515/helm-2017-0037.

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SummaryThis study determined the efficacies of four classes of anthelmintics (AH) in a goat flock where anthelmintic resistance (AR) to ivermectin was suspected. We selected and randomly distributed 105 animals with >500 eggs per gram of feces into seven groups of 15 animals: an untreated control group and groups treated with ivermectin, eprinomectin, albendazole sulfoxide, albendazole, levamisole, and closantel. The goats were individually weighed and treated with the recommended dose. Fecal samples were collected 14 days post-treatment to determine the fecal egg counts and for a fecal egg
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Nascimento, Cristiano Grisi, Gabrielle Bragaglia, Sandra Barioni Toma, Viviane Souza Magalhães, Yara Peluso Cid, and Fabio Barbour Scott. "Injectable eprinomectin for cattle: Tick efficacy and pharmacokinetics." Journal of Veterinary Pharmacology and Therapeutics 43, no. 2 (2020): 171–78. http://dx.doi.org/10.1111/jvp.12840.

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Avcioglu, Hamza, and Ibrahim Balkaya. "Efficacy of eprinomectin against Toxocara vitulorum in calves." Tropical Animal Health and Production 43, no. 2 (2010): 283–86. http://dx.doi.org/10.1007/s11250-010-9699-7.

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Kozan, Esma, Feride Kırcalı Sevimli, Fatih Mehmet Birdane, and Ramazan Adanır. "Efficacy of eprinomectin against Toxacara canis in dogs." Parasitology Research 102, no. 3 (2007): 397–400. http://dx.doi.org/10.1007/s00436-007-0776-4.

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Andresen, Claire E., Dan D. Loy, Troy A. Brick, Lee L. Schulz, and Patrick J. Gunn. "Effects of extended-release eprinomectin on productivity measures in cow–calf systems and subsequent feedlot performance and carcass characteristics of calves." Translational Animal Science 3, no. 1 (2018): 273–87. http://dx.doi.org/10.1093/tas/txy115.

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Abstract The objective of this study was to estimate the impact of a single injection of extended-release eprinomectin on economically relevant production variables in beef cows and calves as well as subsequent feedlot health, performance, and carcass traits of calves compared with a traditional, short duration anthelmintic. Animals from 13 cooperator herds across seven states were stratified within herd and assigned to one of two treatments; injectable doramectin (DOR; Dectomax; n = 828) or injectable eprinomection (EPR; Longrange; n = 832). Fecal samples were randomly collected from a subset
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Kvaternick, Valerie, Michael Kellermann, Martin Knaus, Steffen Rehbein, and Joseph Rosentel. "Pharmacokinetics and metabolism of eprinomectin in cats when administered in a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel." Veterinary Parasitology 202, no. 1-2 (2014): 2–9. http://dx.doi.org/10.1016/j.vetpar.2014.02.031.

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Knaus, Martin, Balázs Capári, Mirjam Szabó, Katrin Kley, and Chris Johnson. "Efficacy of a novel topical combination of esafoxolaner, eprinomectin and praziquantel against Notoedres cati mange in cats." Parasite 28 (2021): 27. http://dx.doi.org/10.1051/parasite/2021023.

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The therapeutic efficacy against notoedric mange of a topical combination of esafoxolaner, eprinomectin and praziquantel (Nexgard® Combo, Boehringer Ingelheim) was evaluated in a masked, controlled clinical study including 14 cats with natural or induced Notoedres cati infestation. Cats were allocated randomly to two groups of seven cats each, to be administered either mineral oil (placebo control) or NexGard® Combo. Each treatment was administered once as spot-on at 0.12 mL per kg body weight (representing the minimum label dosage of NexGard® Combo, i.e. 1.44 mg esafoxolaner, 0.48 mg eprinome
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Hinney, Barbara, Sandra Wiedermann, Waltraud Kaiser, Jürgen Krücken, and Anja Joachim. "Eprinomectin and Moxidectin Resistance of Trichostrongyloids on a Goat Farm in Austria." Pathogens 11, no. 5 (2022): 498. http://dx.doi.org/10.3390/pathogens11050498.

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Anthelmintic resistance (AR) of trichostrongyloids is widespread in Europe, but there is no up-to-date information on the spread of AR in caprine parasites in Austria. Eprinomectin (EPR) is currently the only anthelmintic drug of the macrocyclic lactones registered for goats in Europe. The aim of the present study was to gather information regarding the efficacy of anthelmintics against trichostrongyloids on a dairy goat farm in Austria with reported treatment failure of macrocyclic lactones and to determine the presence of different trichostrongyloid genera. Faecal egg count reduction tests (
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SHERIFF, J. C., A. C. KOTZE, N. C. SANGSTER, and R. J. MARTIN. "Effects of macrocyclic lactone anthelmintics on feeding and pharyngeal pumping in Trichostrongylus colubriformis in vitro." Parasitology 125, no. 5 (2002): 477–84. http://dx.doi.org/10.1017/s0031182002002251.

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The effects of macrocyclic lactone anthelmintics (MLs) on feeding by Trichostrongylus colubriformis nematodes in vitro were examined using inulin uptake as a measure of ingestion and electropharyngeograms as a record of the electrical events associated with pharyngeal pumping. Inulin uptake was inhibited by the 4 MLs tested (EC50s 0.045–4.57 nM), with an order of potency of eprinomectin (most potent), ivermectin, ivermectin monosaccharide, and ivermectin aglycone. The MLs caused both the frequency and amplitude of pharyngeal electrical events to decrease. In individual worms the inhibition of
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Rudik, Irina, Margie R. Cummings, and Robert H. Poppenga. "Isolation and Multiresidue Detection of Macrolide Endectocides Present in Animal Matrices." Journal of Veterinary Diagnostic Investigation 14, no. 4 (2002): 295–302. http://dx.doi.org/10.1177/104063870201400404.

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A simple, rapid, and sensitive method for isolation and detection of macrolide endectocides (moxidectin, doramectin, selamectin, ivermectin, and eprinomectin) in animal sera and liver is described. Fortified sera or homogenized liver samples were treated with sodium chloride followed by organic solvent extraction. No additional steps were required prior to analysis. Separation of analytes and collection of mass information was achieved by liquid chromatography/mass spectrometry with positive atmospheric pressure chemical ionization set in selected ion monitoring mode with each sample analysis
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D’Amico, Gianluca, Adrian-Valentin Potârniche, Bianca-Irina Tucă, and Adriana Györke. "Occurrence of Internal Parasites and Anthelmintic Resistance in Goats." Animals 15, no. 7 (2025): 1024. https://doi.org/10.3390/ani15071024.

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Extensive anthelmintic (AH) use for endoparasitism prevention, especially gastrointestinal strongyle (GIS) infections, led to AH resistance (AR). This study assessed the internal parasitic profile and AR occurrence in goat herds. Five herds (H, n = 300) raised in household systems in Romania (2020–2021) were dewormed with eprinomectin in the fall (H1, H2) and albendazole in the spring (H3–H5). Fecal samples (n = 67) were collected pre- and 14 days post-AH administration. Coprological examinations, coprocultures, and polymerase chain reaction (PCR) were performed. Anthelmintic resistance was de
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Briqué-Pellet, C., N. Ravinet, Y. Quenet, M. Alvinerie, and C. Chartier. "Pharmacokinetics and anthelmintic efficacy of injectable eprinomectin in goats." Veterinary Parasitology 241 (July 2017): 43–47. http://dx.doi.org/10.1016/j.vetpar.2017.05.021.

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Litskas, V. D., X. N. Karamanlis, G. C. Batzias, and A. P. Kamarianos. "Sorption of the antiparasitic drug eprinomectin in three soils." Chemosphere 82, no. 2 (2011): 193–98. http://dx.doi.org/10.1016/j.chemosphere.2010.10.024.

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47

D’Alterio, G. L., A. P. Jackson, T. G. Knowles, and A. P. Foster. "Comparative study of the efficacy of eprinomectin versus ivermectin, and field efficacy of eprinomectin only, for the treatment of chorioptic mange in alpacas." Veterinary Parasitology 130, no. 3-4 (2005): 267–75. http://dx.doi.org/10.1016/j.vetpar.2005.03.036.

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Prullage, Joe, Anthony Pfefferkorn, Martin Knaus, Justin Frost, Elizabeth Mitchell, and Eric Tielemans. "Efficacy of a novel topical combination of esafoxolaner, eprinomectin and praziquantel against Ixodes ricinus and Ixodes scapularis in cats." Parasite 28 (2021): 23. http://dx.doi.org/10.1051/parasite/2021019.

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Esafoxolaner is a purified enantiomer of afoxolaner with insecticidal and acaricidal properties. It is combined with eprinomectin and praziquantel in a novel topical endectoparasiticide formulation for cats. The efficacy of this novel formulation was evaluated in three Ixodes ricinus and two Ixodes scapularis experimental studies, with comparable designs. In each study, cats were randomly allocated, based on a pre-treatment tick infestation and count, to a placebo control group or a group treated with the minimum recommended dose of the novel formulation. Cats were infested two days before tre
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Gupta, Aradhana, Christine Baker, Hailun Wang, Norba Targa, Anthony Pfefferkorn, and Eric Tielemans. "Target animal safety evaluation of a novel topical combination of esafoxolaner, eprinomectin and praziquantel for cats." Parasite 28 (2021): 18. http://dx.doi.org/10.1051/parasite/2021015.

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The safety profile of NexGard®Combo, a novel topical product for cats combining esafoxolaner, eprinomectin and praziquantel, for the treatment and prevention of internal and external parasites, was evaluated in kittens, in two margin-of-safety studies (Studies #1 and #2), and in an oral tolerance study (Study #3). In the margin of safety studies, kittens were dosed several times topically with multiples of the maximum exposure dose (1×): in Study #1, 3× and 5× doses four times at 2-week intervals; in Study #2, 1×, 3× and 5× doses six times at 4-week intervals. In Study #3, kittens were dosed o
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Kolesnikov, V. I. "Efficacy of anthelmintic Eprimek against gastrointestinal nematodes in sheep". Russian Journal of Parasitology 14, № 4 (2020): 99–103. http://dx.doi.org/10.31016/1998-8435-2020-14-4-99-103.

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The purpose of the research is studying the efficacy of Eprimek (Eprinomectin) against gastrointestinal nematodes in sheep.Materials and methods. A commercial experiment to study the antiparasitic efficacy of Eprimek was carried out in June 2020 on 300 lambs of the North Caucasian breed in a private flock of Filimonovskaya Village, Izobilnensky District, the Stavropol Territory, which were divided into two groups. The experimental group of lambs (290 animals) was injected Eprimek subcutaneously at the earset at a dose of 1 ml/50 kg of live weight (10 mg of Eprinomectin in 1 ml), and 10 lambs were
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