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Douglas, Steve, and Hollie Raynor. "Differences in Body Mass Index Z-Scores Among Children and Adolescent Participants of NHANES 2003–2016 with Different Temporal Eating Patterns." Current Developments in Nutrition 4, Supplement_2 (May 29, 2020): 586. http://dx.doi.org/10.1093/cdn/nzaa047_006.
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Abstract Objectives To determine if body mass index z-scores (zBMI) differ among children and adolescents who reported an early temporal eating pattern when compared to those who reported other temporal eating patterns. Methods Data from children (6–12 years) and adolescents (13–19 years) participating in the National Health and Nutrition Examination Survey 2003–2016 were used. Children and adolescents were analyzed separately because of the phase delay in circadian rhythms experienced during adolescence. Energy intake and timing of intake was assessed using two 24-hour dietary recalls. Children (n = 2,565) and adolescents (n = 2,321) were included if they reported plausible intakes (≥500 kcals/day) with the same temporal eating patterns on both days. Temporal eating patterns were defined by the following morning and evening parameters: consumed 20% of total caloric intake before 10 AM (EAM); didn't consume 20% before 10 AM (LAM); consumed at least 80% of total caloric intake before 7 PM (EPM); didn't consume 80% before 7 PM (LPM). These parameters provided four temporal eating patterns: EAM-EPM, EAM-LPM, LAM-EPM, LAM-LPM. A covariate adjusted general linear models, adjusted for the complex sampling design, was used to compare zBMI of those participating in the different patterns. Data are reported as means ± SEM and P < 0.0125 was considered significant. Results zBMI for EAM-EPM (n = 887; 0.460 ± 0.037) children was lower when compared to LAM-LPM (n = 455; 0.641 ± 0.056; P = 0.007) children. For adolescents, zBMI for EAM-EPM (n = 445; 0.516 ± 0.048; P = 0.005), EAM-LPM (n = 172; 0.370 ± 0.089; P = 0.001), and LAM-LPM (n = 839; 0.549 ± 0.039; P = 0.011) adolescents were lower when compared to LAM-EPM (n = 1,097; 0.683 ± 0.035) adolescents. No other differences were observed. Conclusions Children between the ages of 6 and 12 who reported consuming an early eating pattern have a lower zBMI when compared to those who reported consuming a later eating pattern. Adolescents who didn't consume 20% of their total energy intake before 10 am and did consume more than 80% of their total intake before 7 pm have a greater zBMI than their peers who consistently reported consuming alternative eating patterns. Funding Sources None
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Jones, William E. "EPM update." Journal of Equine Veterinary Science 22, no. 12 (December 2002): 528–34. http://dx.doi.org/10.1016/s0737-0806(02)70192-5.
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Corlett, E. N. "EPM introduction." Applied Ergonomics 23, no. 1 (February 1992): 3. http://dx.doi.org/10.1016/0003-6870(92)90003-e.
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Fei, Jiaer, and Wen Liu. "Review and Comparison of Classical Entrepreneurial Intention Models." Proceedings of Business and Economic Studies 6, no. 1 (February 2, 2023): 8–14. http://dx.doi.org/10.26689/pbes.v6i1.4709.
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The study of entrepreneurial models carries significance in guiding the development of entrepreneurial activities. On the basis of a literature review, this paper reviews and analyzes six classic and widely influential entrepreneurial models: entrepreneurial event model (EEM), entrepreneurial intention model (EIM), revised EIM, theory of planned behavior (TPB), economic psychological model (EPM), and structural model of entrepreneurial intention (SMEI). This paper aims to discuss the similarities and differences of these entrepreneurial intention models and their applications in different contexts, which carries important theoretical and practical significance for further research on entrepreneurial behavior and intention.
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Yu, Qian, Tong Li, Xuan Zhang, Ying Lin, Yong Yu, and Na Zhao. "Algorithm of Representing and Preparing for Resources in EEM." Advanced Materials Research 989-994 (July 2014): 2144–47. http://dx.doi.org/10.4028/www.scientific.net/amr.989-994.2144.
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Software evolution process model (EPM) is a knowledge-intensive process which is described in EPDL(Software Evolution Process Description Language) and modelled by semi-formal approach based on EPMM(Software Evolution Process Meta-Model). EPM’s execution model (EEM) is represented by logic programming to create the knowledge base of EPM during constructing the EEM. Only its needing all kinds of resources are satisfied by system execution environment is activity in EEM implemented. The paper discussed the method and the algorithm of preparing resources is respectively presented in order to execute the EEM automatically. The converter program is realized and the correct results have presented to prove the correctness of the method.
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Lu, Jiajun, Shunda Zhan, Bowen Liu, and Yonghua Zhao. "Plasma-enabled electrochemical jet micromachining of chemically inert and passivating material." International Journal of Extreme Manufacturing 4, no. 4 (August 9, 2022): 045101. http://dx.doi.org/10.1088/2631-7990/ac84b3.
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Abstract Electrochemical jet machining (EJM) encounters significant challenges in the microstructuring of chemically inert and passivating materials because an oxide layer is easily formed on the material surface, preventing the progress of electrochemical dissolution. This research demonstrates for the first time a jet-electrolytic plasma micromachining (Jet-EPM) method to overcome this problem. Specifically, an electrolytic plasma is intentionally induced at the jet-material contact area by applying a potential high enough to surmount the surface boundary layer (such as a passive film or gas bubble) and enable material removal. Compared to traditional EJM, introducing plasma in the electrochemical jet system leads to considerable differences in machining performance due to the inclusion of plasma reactions. In this work, the implementation of Jet-EPM for fabricating microstructures in the semiconductor material 4H-SiC is demonstrated, and the machining principle and characteristics of Jet-EPM, including critical parameters and process windows, are comprehensively investigated. Theoretical modeling and experiments have elucidated the mechanisms of plasma ignition/evolution and the corresponding material removal, showing the strong potential of Jet-EPM for micromachining chemically resistant materials. The present study considerably augments the range of materials available for processing by the electrochemical jet technique.
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Silva, Jorge M., Ana Vera Machado, and João M. Maia. "Transient Rheological Behaviour of PA6/EPM/EPM-g-MA Blends." Materials Science Forum 514-516 (May 2006): 853–57. http://dx.doi.org/10.4028/www.scientific.net/msf.514-516.853.
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In this work the transient shear behaviour, in terms of both flow and stress relaxation, were measured for several blends of PA6/EPM/EPM-g-MA. The results indicate that there is a competition between slip at the interface due to the non-compatibility between the PA6 and the EPM and the action of the compatibilizer. In flow experiments, at low total strains it was observed that the behaviour is characteristic of immiscible polymer blends and gradually changes to that typical of compatible blends. This suggests that initially the action of the compatibilizer (especially for low compatibilizer contents) is not enough to prevent the lower viscosity PA matrix from slipping around the high viscosity EPM droplets. However, as the droplets are deformed and oriented, the increase in interfacial area enhances the performance of the compatibilizer, thus resulting in a much better interaction between the two phases across the interface.
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Neher, Alain, and Jane Maley. "Improving the effectiveness of the employee performance management process." International Journal of Productivity and Performance Management 69, no. 6 (November 18, 2019): 1129–52. http://dx.doi.org/10.1108/ijppm-04-2019-0201.
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Purpose The purpose of this paper is to explore the role of managerial values in improving the effectiveness of employee performance management (EPM). Design/methodology/approach The research has been conducted as a conceptual study, in which EPM criteria are compared to managerial values and the related maturity model. A thorough review of the EPM and values literature identified relevant and significant works. Findings Despite copious extant literature on EPM, the process is riddled with persistent problems, particularly concerning the manager’s enthusiasm to adequately implement EPM and its subsequent effectiveness. A managerial grounded values framework is, therefore, proposed. Using a circular approach that is assisted by a values maturity model, it serves as a charter that guides the supervisor’s actions, goals, choices, decisions and attitudes; principles that are very much at the heart of an effective EPM process. Curiously, managerial values and EPM have not generally been connected. Practical implications This values-based circular framework contributes to the effectiveness of the EPM process and thus to a positive EPM experience that motivates, enhances engagement and guides personal development. When enacted individual values and EPM are linked, they are argued to lead to sustained superior financial performance. Originality/value This study makes an important and novel contribution to the performance literature by using a values-based maturity model to improve the effectiveness of the EPM process.
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Ravid, Daniel M., David L. Tomczak, Jerod C. White, and Tara S. Behrend. "EPM 20/20: A Review, Framework, and Research Agenda for Electronic Performance Monitoring." Journal of Management 46, no. 1 (August 20, 2019): 100–126. http://dx.doi.org/10.1177/0149206319869435.
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Electronic performance monitoring (EPM) refers to the use of technological means to observe, record, and analyze information that directly or indirectly relates to job performance. The last comprehensive review of the EPM literature was published in 2000. Since 2000, dramatic advances in information technologies have created an environment in which organizations are able to monitor employees to a greater extent and with greater intensity than was previously possible. Moreover, since that time, considerable research has been devoted to understanding the effects of EPM on individual performance and attitudes. Contradictory findings in the EPM literature exist, suggesting that EPM is a multidimensional phenomenon and one for which contextual and psychological variables are pertinent. Thus, we propose a theory-based typology of EPM characteristics and use this typology as a framework to review the EPM literature and identify an agenda for future research and practice.
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Mayhew, I. G. "Equine protozoal myeloencephalitis (EPM)." Equine Veterinary Education 8, no. 1 (February 1996): 37–39. http://dx.doi.org/10.1111/j.2042-3292.1996.tb01648.x.
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Digby, N. Wingfield. "Equine protozoal myeloencephalitis (EPM)." Equine Veterinary Education 8, no. 6 (December 1996): 347. http://dx.doi.org/10.1111/j.2042-3292.1996.tb01720.x.
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Mayhew, I. G. "Equine protozoal myeloencephalitis (EPM)." Equine Veterinary Education 8, S2 (June 10, 2010): 29–31. http://dx.doi.org/10.1111/j.2042-3292.1996.tb01851.x.
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Pitjeva, E. V. "EPM ephemerides and relativity." Proceedings of the International Astronomical Union 5, S261 (April 2009): 170–78. http://dx.doi.org/10.1017/s1743921309990342.
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AbstractIn the seventies of the last century the EPM ephemerides (Ephemerides of Planets and the Moon) of IAA RAS originated and have been developed since that time. These ephemerides are based upon relativistic equations of motion of celestial bodies and light rays and upon relativistic time scales. The updated model of EPM2008 includes the new values of planet masses and other constants, the improved dynamical model with adding Trans–Neptunian Objects and the expanded database (1913–2008). More than 260 parameters have been determined while improving the planetary part of EPM2008 to 550000 observations. EPM2008 have been oriented to ICRF by including into the total solution the VLBI data of spacecraft near the planets. The real uncertainty of EPM ephemerides has been checked by comparison with the JPL's DE ephemerides. Some estimates of the post–model parameters have been obtained: |1−β| < 0.0002, |1−γ| < 0.0002, /G = (−5.9±4.4) ⋅ 10−14 per year, the statistic zero corrections to the planet perihelion advances.
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Polgar, L. M., N. Migliore, F. Picchioni, and M. Van Duin. "Sustainable EPM rubber compounds." Polymer-Plastics Technology and Materials 59, no. 12 (March 13, 2020): 1379–85. http://dx.doi.org/10.1080/25740881.2020.1738480.
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Schleifer, Lawrence M. "Electronic performance monitoring (EPM)." Applied Ergonomics 23, no. 1 (February 1992): 4–5. http://dx.doi.org/10.1016/0003-6870(92)90004-f.
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Yu, Qian, Ying Lin, Xuan Zhang, Fei Dai, and Na Zhao. "Research on Information Technology with Transformation Method of Activity from EPMM-Based Software Evolution Process Model to its Execution Model." Advanced Materials Research 886 (January 2014): 637–41. http://dx.doi.org/10.4028/www.scientific.net/amr.886.637.
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Software evolution process model (EPM) is created in terms of a formal evolution process meta-model (EPMM) and semi-formal approach to modeling based on EPMM. EPM is still abstract at higher abstract level and is general while software process is concrete, so EPM must be instantiated before its enactment. The method to transform any EPM to its execution model based on logic programming is proposed. Since activity contains the imports resource, roles resource, exports resource and tasks, the rules to transform the four parts of activity level of any EPM to its execution model based logic programming are respectively proposed by analyzing the execution semantics of the activities and the tasks in EPM. The converter program is realized and the correct results have presented to prove the correctness of the method.
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Locher, H. H., H. Schlunegger, P. G. Hartman, P. Angehrn, and R. L. Then. "Antibacterial activities of epiroprim, a new dihydrofolate reductase inhibitor, alone and in combination with dapsone." Antimicrobial Agents and Chemotherapy 40, no. 6 (June 1996): 1376–81. http://dx.doi.org/10.1128/aac.40.6.1376.
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Epiroprim (EPM; Ro 11-8958) is a new selective inhibitor of microbial dihydrofolate reductase. EPM displayed excellent activity against staphylococci, enterococci, pneumococci, and streptococci which was considerably better than that of trimethoprim (TMP). EPM was also active against TMP-resistant strains, although the MICs were still relatively high. Its combination with dapsone (DDS) was synergistic and showed as in vitro activity superior to that of the TMP combination with sulfamethoxazole (SMZ). The EPM-DDS (ratio, 1:19) combination inhibited more than 90% of all important gram-positive pathogens at a concentration of 2 + 38 micrograms/ml. Only a few highly TMP-resistant staphylococci and enterococci were not inhibited. EPM was also more active than TMP against Moraxella catarrhalis, Neisseria meningitidis, and Bacteroides spp., but it was less active than TMP against all other gram-negative bacteria tested. Atypical mycobacteria were poorly susceptible to EPM, but the combination with DDS was synergistic and active at concentrations most probably achievable in biological fluids (MICs from 0.25 +/- 4.75 to 4 + 76 micrograms/ml). EPM and the EPM-DDS combination were also highly active against experimental staphylococcal infections in a mouse septicemia model. The combination EPM-DDS has previously been shown to exhibit activity in Pneumocystis carinii and Toxoplasma models and, as shown in the present study, also shows good activity against a broad range of bacteria including many strains resistant to TMP and TMP-SMZ.
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IMPERIALE, FERNANDA, ALEJANDRA PIS, JUAN SALLOVITZ, ADRIÁN LISFCHITZ, MARGARITA BUSETTI, VICTOR SUÁREZ, and CARLOS LANUSSE. "Pattern of Eprinomectin Milk Excretion in Dairy Sheep Unaffected by Lactation Stage: Comparative Residual Profiles in Dairy Products." Journal of Food Protection 69, no. 10 (October 1, 2006): 2424–29. http://dx.doi.org/10.4315/0362-028x-69.10.2424.
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Eprinomectin (EPM) is a broad-spectrum endectocide compound approved for use in dairy cattle with a zero milk-withdrawal period, but has not been registered for use in lactating dairy sheep. The pattern of EPM excretion in milk was comparatively characterized following its pour-on administration (500 μg/kg) to lactating dairy sheep at two different stages of lactation. The relationship between milk excretion and plasma disposition kinetics of EPM was characterized. Residual EPM concentrations were assessed during cheese making (whey and curd) and ripening (cheese) by high-performance liquid chromatography and fluorescence detection. EPM was poorly distributed from the bloodstream to the mammary gland and low concentrations were excreted in milk. The level of milk production (early-mid and mid-late lactation) did not affect either the plasma-milk distribution or the pattern of residual concentrations in milk. During cheese making, the highest residual concentrations of EPM were measured in the curd, which increased during cheese ripening, reaching a maximum after 40 days. However, these residual concentrations were below the maximum residue limit of 20 ng/ml established for EPM in bovine's milk. Therefore, these dairy products could be considered safe for consumers after the EPM antiparasitic pour-on treatment (500 μg/kg) in lactating dairy sheep.
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Sakae, Diana Yae, Thiago Mamoru Sakae, Marta Aparecida Paschoalini, and Moacir Serralvo Faria. "Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats." Arquivos de Neuro-Psiquiatria 73, no. 7 (July 2015): 601–6. http://dx.doi.org/10.1590/0004-282x20150088.
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Objective This study evaluated the provision of two configuration of the Elevated Pluz-Maze (EPM) by analizing the exploratory behaviour of female Wistar rats in different phases of the estrous cycle in EPMs with different gradients of luminosity between the open and enclosed arms (O/E∆Lux).Methods Female Wistar rats were treated with Midazolam (MDZ, 1.0 mg.kg-1) and were tested for their exploratory behaviour in either the EPM 10 O/E∆Lux or EPM 96 O/E∆Lux.Results A multiple regression analysis indicated that the O/E∆Lux is negatively associated with the %Open arm entries and %Open arm time, suggesting that as O/E∆Lux increases, the open arm exploration decreases. The estrous cycle phase did not influence the open-arm exploration in either EPM. MDZ- induced anxiolysis was detected in 96 O/E∆Lux EPM in all phases of the EC.Discussion Results of this study suggest the importance of the O/E∆Lux to establish the arm preference in the EPM, and to preserve the predictive validity of the EPM.
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Teoh, Boon Yew, Misni Misran, Zhi Zhang Tan, and Poh Foong Lee. "DESIGN AND EVALUATION OF A NEW ELECTROPHORETIC MOBILITY MEASUREMENT INSTRUMENT USING MICROELECTROPHORESIS SYSTEM WITH IMAGE PROCESSING METHOD." Biomedical Engineering: Applications, Basis and Communications 29, no. 05 (October 2017): 1750036. http://dx.doi.org/10.4015/s1016237217500363.
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Electrophoretic mobility (EPM) measurement on biological particles in fluids is well established. The current method in measuring EPM is using laser which the target particles are not visible. Additional morphology information is critical for the EPM measurement. Image processing is a promising method to obtain the EPM together with the morphology information. In this study, a setup of micro electrophoresis system with a compact CCD microscope was constructed. This setup was equipped with image processing method for capturing the images of the moving particles in an electric field. With the image processing method (Horn–Schunck method), the images captured were processed in real time to obtain the EPM of the particle. Velocity of the particles was then measured and the particles’ EPM was obtained. With the captured images of the particles in real time, the system can present the image of the targeted particle together with the EPM value. The setup of this prototype was calibrated with discrete particles (Polystyrene microsphere size of 10[Formula: see text][Formula: see text]m[Formula: see text] 5%) and with a magnification value of 125[Formula: see text]X. This system is suitable for the surface charge measurement of discrete particle with size in between 4[Formula: see text][Formula: see text]m and 20[Formula: see text][Formula: see text]m. Comparison of commercialized device with our laboratory setup for calibration on EPM of polystyrene beads had a variance of solely 13%. Measurement on yeast cells, normal (hFob 1.19) and cancer bone cells (U2OS) indicated that the EPM of yeast became highly negative in the pH value of 4.5 and 6.5. The negative EPM of the cancer cell is slightly larger than that of the normal cell for pH ranging from 4.4 to 5.0. In conclusion, the real-time EPM measurement set up for this study is able to display the real-time images of the moving particles in fluid suspension during measurement.
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Hirai, Yohei, Derek Radisky, Rosanne Boudreau, Marina Simian, Mary E. Stevens, Yumiko Oka, Kyoko Takebe, Shinichiro Niwa, and Mina J. Bissell. "Epimorphin Mediates Mammary Luminal Morphogenesis through Control of C/EBPβ." Journal of Cell Biology 153, no. 4 (May 14, 2001): 785–94. http://dx.doi.org/10.1083/jcb.153.4.785.
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We have shown previously that epimorphin (EPM), a protein expressed on the surface of myoepithelial and fibroblast cells of the mammary gland, acts as a multifunctional morphogen of mammary epithelial cells. Here, we present the molecular mechanism by which EPM mediates luminal morphogenesis. Treatment of cells with EPM to induce lumen formation greatly increases the overall expression of transcription factor CCAAT/enhancer binding protein (C/EBP)β and alters the relative expression of its two principal isoforms, LIP and LAP. These alterations were shown to be essential for the morphogenetic activities, since constitutive expression of LIP was sufficient to produce lumen formation, whereas constitutive expression of LAP blocked EPM-mediated luminal morphogenesis. Furthermore, in a transgenic mouse model in which EPM expression was expressed in an apolar fashion on the surface of mammary epithelial cells, we found increased expression of C/EBPβ, increased relative expression of LIP to LAP, and enlarged ductal lumina. Together, our studies demonstrate a role for EPM in luminal morphogenesis through control of C/EBPβ expression.
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Harrow, Jenny, and Tobias Jung. "The European philanthropy manifesto: ‘clearly needed and a very good thing'?" Voluntary Sector Review 11, no. 3 (November 1, 2020): 383–94. http://dx.doi.org/10.1332/204080519x15681051942478.
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Launched in March 2019, the European philanthropy manifesto (EPM) argues for the introduction of a single market for philanthropy. Examining the historic precedents of that idea and the recommendations put forward in the EPM to achieve the single market, in this policy review we critically reflect on the potential and shortcomings of the EPM.
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Koenhardono, Eddy S., Eko Budi Djatmiko, Adi Soeprijanto, and Mohammad I. Irawan. "Neural Network-Based Engine Propeller Matching (NN-EPM) for Trimaran Patrol Ship." Applied Mechanics and Materials 493 (January 2014): 388–94. http://dx.doi.org/10.4028/www.scientific.net/amm.493.388.
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In recent years efforts on reducing fuel consumption has become the greatest issue related to energy crisis and global warming. The reduction of fuel consumption can be obtained, if the ship propulsion could be operated in its best performance level. Generally this is done by an appropriate analysis of engine propeller matching (EPM). In this study an EPM based on neural-network method, or NN-EPM, is established to predict the best performance of main engines, leading at minimum fuel oil consumption. A trimaran patrol ship is selected as a case study. This patrol ship is equipped with two 2720 kW main engines each connected to a controllable pitch propeller (CPP) through a reduction gear. The input parameters are ship speedVand service margin SM, with the corresponding output parameters comprise of engine speednE, engine break horse powerPB, propeller pitchP/D, and the fuel consumptionFC. An NN-EPM 2-20-15-4 configuration has been constructed out of 100 training data and then validated by 30 testing data. The maximum relative error between results from NN-EPM and EPM analysis is 2.1%, that is in term of the fuel consumption. For other parameters the errors are well below 1.0%. These facts indicate that the use of NN-EPM to predict the main engines's performance for trimaran patrol ship is satisfactory.
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Zhou, Wenwen, Haoran Jia, Lang Liu, Baotong Li, Yuqi Li, and Meizhu Gao. "Environmental behaviors of (<i>E</i>) pyriminobac-methyl in agricultural soils." SOIL 8, no. 1 (March 31, 2022): 237–52. http://dx.doi.org/10.5194/soil-8-237-2022.
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Abstract. E or pyriminobac-methyl (EPM), a pyrimidine benzoic acid esters herbicide, has a high potential as weedicide; nevertheless, its environmental behaviors are still not well understood. In this study, we systematically investigated, for the first time, the adsorption–desorption, degradation, and leaching behaviors of EPM in agricultural soils from five exemplar sites in China (Phaeozems – S1; Anthrosol – S2; Ferralsol – S3; Alisol – S4; Plinthosol – S5) through laboratory simulation experiments. Our results show that the EPM adsorption–desorption results were well fitted by the Freundlich model (R2>0.9999). In the analyzed soils, the Freundlich adsorption (i.e., Kf ads) and desorption (i.e., Kf des) coefficients of EPM varied between 0.85 and 32.22 mg1-1/n L1/n kg−1 and 0.78–5.02 mg1-1/n L1/n kg−1, respectively. The mobility of EPM in soils S1–S5 was categorized as immobile, slightly immobile, highly mobile, slightly mobile, and slightly mobile, respectively. Moreover, the degradation of EPM reflected first-order kinetics, where its half-life ranged between 37.46 and 66.00 d, depending on the environmental conditions, and abiotic degradation was predominant in the degradation of this compound. Overall, the high leaching ability and desorption capacity of EPM were accompanied by a low adsorption capacity, and there were no significant relationships between pH and the leaching rate of EPM in the five types of soils. In contrast, the organic matter content, cation exchange capacity, and soil clay content were the main components responsible for the observed leaching rates. We found that EPM degrades easily, has a high adsorption affinity, and a low mobility in S1, which results in a low contamination risk for groundwater systems. On the contrary, this compound degrades slowly in S2, S3, S4, and S5, due to a low adsorption affinity and moderate mobility, which results in a high contamination risk for groundwater systems. Therefore, our results may serve as a reference for evaluating the risks involved in the increasingly wide application of this compound.
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Long, Jian Xiong. "Implementation of Decision Support System for Electric Power Marketing." Applied Mechanics and Materials 63-64 (June 2011): 168–71. http://dx.doi.org/10.4028/www.scientific.net/amm.63-64.168.
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A DSS of business-oriented theme has been established by using the EPM information integration platform. Under the EPM business requirements, the DSS toolkits have been solved and a comprehensive algorithm for decision support has been achieved on the basis of these toolkits. Through a practical application case, the analysis reports and the prediction evaluations for the EPM business can be processed flexibly with this system.
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Jensen, Thomas Bo, Espen Jimenez-Solem, Rikke Cortes, Cecilie Betzer, Sara Bøge Breinholt, Kasper Meidahl Petersen, Tonny Studsgaard Petersen, Jakob Kjellberg, Hanne Rolighed Christensen, and Jon Trærup Andersen. "Content and validation of the Electronic Patient Medication module (EPM)—the administrative in-hospital drug use database in the Capital Region of Denmark." Scandinavian Journal of Public Health 48, no. 1 (March 1, 2018): 43–48. http://dx.doi.org/10.1177/1403494818760050.
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Aims: Registries on in-hospital drug use are sparse, especially those that can be linked to nationwide registries. In this study, we present and validate the Electronic Patient Medication module (EPM)—the electronic administrative database on in-hospital drug use covering the Capital Region of Denmark. Methods: The research database (EPM-research) is an adaptation of the database underlying the electronic administrative database for in-hospital drug use (EPM-clinic). The validation study was comprised of two sub-studies. Sub-study 1: Accordance of registration between EPM-clinic and EPM-research was investigated by analyzing randomly chosen retrospective patient records. Sub-study 2: Workflows and real-life registration practices were investigated through visits to three different (two medical and one emergency) departments. An observer followed a nurse while dispensing and administering drugs. This information was compared with EPM-research. The primary endpoint for both sub-studies was accordance of generic name between registrations. Secondary endpoints were exact brand name, dose, and time of each administration. Accordance (proportions) with 95% confidence intervals (CI) using the Clopper-Pearson method were calculated. The study was approved by the Danish Data Protection Agency (BFH-2016-058-04906) and the Danish Patient Safety Authority (3-3013-1884/1/). Results: In sub-study 1 227 retrospective drug administrations were reviewed. Accordance of generic name was 100.0% (CI 98.4%−100.0%). In sub-study 2 176 drug administrations were observed of which 173 were recorded with identical generic name, resulting in 98.3% (CI 95.1%-99.6%) accordance of data. Conclusions: Our validation of the EPM-research showed very high accordance. With detailed information on in-hospital drug use, the EPM-research may be a useful tool in pharmacoepidemiological research.
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Polgar, L. M., J. Keizer, R. Blom, B. Niemeijer, T. de With, F. Picchioni, and M. van Duin. "THERMOREVERSIBLE CROSS-LINKING OF RUBBER COMPOUNDS: FROM PROOF-OF-CONCEPT TOWARD AN INDUSTRIAL PROCESS." Rubber Chemistry and Technology 91, no. 2 (April 1, 2018): 492–508. http://dx.doi.org/10.5254/rct-18-82638.
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ABSTRACT It is demonstrated that the concept of thermoreversible cross-linking of functionalized maleic anhydride grafted ethylene–propylene (EPM-g-MA) rubber using Diels–Alder chemistry is limited neither to laboratory scale using a solvent route nor to gum rubber. The use of an internal mixer is the first step toward an industrial process, since it greatly reduces the processing time and allows for a solventless process for the furan-functionalization and subsequent bismaleimide cross-linking of EPM rubber. Practical rubber compounds were prepared by mixing thermoreversibly cross-linked EPM with carbon black and mineral oil in the same batch mixer. This resulted in reinforcement of the rubber without affecting the thermoreversible character of the cross-linking. The pendant furan groups of the (non)cross-linked EPM-g-furan interact with the carbon black filler. Finally, crystalline EPM rubber compounds were prepared, which show excellent material properties and property retention over multiple reprocessing cycles.
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Dikland, H. G., and M. Van Duin. "Miscibility of EPM-EPDM Blends." Rubber Chemistry and Technology 76, no. 2 (May 1, 2003): 495–506. http://dx.doi.org/10.5254/1.3547756.
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Abstract Blends of elastomers are often used as a basis for compound formulations. For instance, tire tread formulations may contain NR, BR and SBR in order to provide cost-effective products with good mechanical properties, dynamic properties and abrasion resistance. Blends of dissimilar EPDM grades are often used when formulating EPDM compounds. In many cases such EPDM-EPDM blends are used to obtain synergy, i.e. properties of the parent EPDM grades are not averaged, but favorable properties of the blend components are combined or unfavorable properties suppressed. In the present paper the miscibility regime for gum stock EPDM-EPDM blends has been calculated based on elementary thermodynamic considerations. Results of calculations have been validated by experiments, and excellent agreement was found. It was found that the chemical composition of EPDM grades has a major influence on miscibility. It is concluded that, as a rule of thumb, two EPDM grades are thermodynamically miscible if the difference between the combined ethylene and third monomer content is less than 12 % by weight. Based on the results it is possible to understand and to some extent predict the behavior of rubber products based on dissimilar EPDM grades.
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Covas, J. A., A. V. Machado, and M. Van Duin. "Rheology of PA-6/EPM/EPM-g-MA blends along a twin-screw extruder." Advances in Polymer Technology 19, no. 4 (2000): 260–76. http://dx.doi.org/10.1002/1098-2329(200024)19:4<260::aid-adv3>3.0.co;2-c.
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Mannarino, Laura, Lara Paracchini, Federica Pezzuto, Gheorghe Emilian Olteanu, Laura Moracci, Luca Vedovelli, Irene De Simone, et al. "Epithelioid Pleural Mesothelioma Is Characterized by Tertiary Lymphoid Structures in Long Survivors: Results from the MATCH Study." International Journal of Molecular Sciences 23, no. 10 (May 21, 2022): 5786. http://dx.doi.org/10.3390/ijms23105786.
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Pleural mesothelioma (PM) is an aggressive tumor with few therapeutic options. Although patients with epithelioid PM (ePM) survive longer than non-epithelioid PM (non-ePM), heterogeneity of tumor response in ePM is observed. The role of the tumor immune microenvironment (TIME) in the development and progression of PM is currently considered a promising biomarker. A few studies have used high-throughput technologies correlated with TIME evaluation and morphologic and clinical data. This study aimed to identify different morphological, immunohistochemical, and transcriptional profiles that could potentially predict the outcome. A retrospective multicenter cohort of 129 chemonaive PM patients was recruited. Tissue slides were reviewed by dedicated pathologists for histotype classification and immunophenotype of tumor-infiltrating lymphocytes (TILs) and lymphoid aggregates or tertiary lymphoid structures (TLS). ePM (n = 99) survivors were further classified into long (>36 months) or short (<12 months) survivors. RNAseq was performed on a subset of 69 samples. Distinct transcriptional profiling in long and short ePM survivors was found. An inflammatory background with a higher number of B lymphocytes and a prevalence of TLS formations were detected in long compared to short ePM survivors. These results suggest that B cell infiltration could be important in modulating disease aggressiveness, opening a pathway for novel immunotherapeutic approaches.
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Hendro, Immanuel, Rama Nusjirwan, and Putie Hapsari. "Faktor-faktor Prediktor Mortalitas 30 Hari pada Pasien dengan Efusi Pleura Maligna yang Telah Dilakukan Chest Tube Thoracostomy di RSUP DR. Hasan Sadikin." Jurnal llmu Bedah Indonesia 47, no. 1 (June 8, 2020): 3–21. http://dx.doi.org/10.46800/jibi-ikabi.v47i1.15.
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Latar Belakang: Efusi pleura maligna (EPM) adalah salah satu bentuk infiltrasi dan metastasis suatu kanker. Adanya EPM menunjukkan penyakit keganasan sudah berada pada tahap lanjut. Hal ini akan mempengaruhi kualitas hidup pasien serta mengindikasikan angka harapan hidup rendah. Dengan angka harapan hidup yang berkisar antara beberapa hari hingga 12 bulan, pasien kanker stadium lanjut akan menderita dari segi fisik, psikososial, dan spiritual, karenanya pengobatan bersifat paliatif dan fokus pada perbaikan kualitas hidup. Tatalaksana pasien dengan EPM adalah melakukan drainase cairan pleura, yang dapat dilakukan dengan chest tube thoracostomy (CTT) atau torakosintesis. Beberapa faktor dipercaya berpengaruh pada tingkat mortalitas pasien dengan EPM yang dilakukan CTT. Penelitian ini untuk mengetahui faktor- faktor prediktor mortalitas 30 hari pasien dengan EPM yang dilakukan CTT.
Metode: Penelitian ini adalah studi kohort prospektif terhadap pasien EPM dan dilakukan CTT di RSUP Dr. Hasan Sadikin (RSHS) selama periode Desember 2017 – April 2018. Dilihat asal tumor, leukositosis, anemia, hipoprotein cairan pleura, kadar pH cairan pleura, skor performa ECOG, dan asidosis respiratorik, kemudian pasien di observasi selama 30 hari. Selanjutnya dilakukan uji statistik bivariat dengan uji Chi-Square dan Fisher, kemudian dilakukan uji statistik multivariat dengan menggunakan regresi logistik.
Hasil: Terdapat 34 pasien EPM yang memenuhi syarat penelitian, mayoritas pasien hidup, yaitu sebanyak 23 pasien (67,6%). Rata-rata usia pasien yang hidup adalah 48,09 ± 16,209 tahun, sedangkan yang meninggal adalah 42,18 ± 18,110 tahun. Rata-rata lama rawat pasien yang hidup adalah 31,70 ± 11,392 hari, sedangkan yang meninggal adalah 6,64 ± 4,154 hari. Pada pasien EPM yang meninggal didapatkan beberapa faktor yang memiliki hubungan bermakna dengan angka mortalitas, yaitu asal tumor (p = 0,044), leukositosis (p = 0,039), anemia (p = 0,039), hipoprotein cairan pleura (p < 0,01), kadar pH cairan pleura (p < 0,01), dan skor performa ECOG (p < 0,01), sedangkan asidosis respiratorik tidak memiliki hubungan yang bermakna terhadap angka mortalitas (p = 0,549).
Simpulan: Asal tumor, leukositosis, anemia, hipoprotein cairan pleura, kadar pH cairan pleura dan skor performa ECOG dapat dijadikan sebagai prediktor mortalitas 30 hari pada pasien dengan EPM yang dilakukan CTT.
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Schreuder-Stacer, H. L. "Peel Strength of Composite Layered Joints." Rubber Chemistry and Technology 61, no. 5 (November 1, 1988): 794–811. http://dx.doi.org/10.5254/1.3536219.
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Abstract 1. Master curves of R/A/R (rubber/adhesive/rubber) type adhesion tests were generated by laterally shifting the rate curves of peel response with empirically determined shift factors. The universal form of the WLF Equation (3) did not shift the data into continuous master curves, due to the individual contributions of each deforming layer. 2. For the weakly-bonded A/EPM system, rate curves were shifted into good agreement using the universal form of the WLF relation and the Tg of EPM. However, in the case of EPM/A, shift factors calculated by the WLF Equation (3) did not create a smooth master curve. Lateral shifting produced a master curve of EPM/A peel response and resulted in experimentally determined shift factors which fell between the shift factors of the EPM and the adhesive. Apparently, the EPM substrate of low Tg completely dominated the viscoelastic response of the A/EPM joint and even exerted some influence over the debonding process for the EPM/A joint, where the detaching layer was comprised only of adhesive. 3. In the case of strongly bonded chloroprene systems, CR/A/CR data were shifted laterally, but the CR/A and A/CR data shifted well with log aT values calculated from the WLF equation. Adhesive and CR Tg's were within ten degrees, and the rubber layer therefore appeared to contribute little to the overall viscoelastic response of CR/A/CR and CR/A. 4. Detachment of EPM systems was entirely interfacial, except in regions of rate where the adhesive was forced to fail in an unfavorable mode (the low-rate EPM/A experiment and the high-rate A/EPM experiment). A distinct transition of interfacial failure was observed near the glass-transition temperature of the adhesive. As the adhesive failure site changed from substrate to backing, even at the same rate and temperature, a three-fold drop in adhesive fracture energy occurred. 5. CR systems debonded through cohesive rupture of the adhesive layer at low rates. Clean interfacial failure occurred at intermediate to high peel rates. A failure site transition occurred in the same rate and temperature region as the weakly-bonded transition. This failure site change was again associated with a three-fold drop in adhesive-fracture energy. However, the actual peel force difference resulting from this transition in CR/A/CR was on the order of 1000 N/m, while the weakly bonded EPM/A/EPM system experienced a drop of approximately 100 N/m. This disparity in the two transitions suggests that the driving mechanism for the substrate-to-backing failure change is not caused simply by added adhesive bending forces in the low-rate failure mode. 6. Relative contributions of each deforming material to the total peel response for an R/A/R system cannot be determined by examining the shift factor dependence upon temperature. However, R/A and A/R models of the R/A/R detachment modes illustrate the contributions of each layer: as the adhesive debonds from the substrate, both adhesive and rubber contribute to the viscoelastic response of peel, except in the case where both layers exhibit similar Tg's; during adhesive failure from the backing, only the rubber backing contributes to the peel response.
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Zeng, Yuchao, Fangdi Sun, and Haizhen Zhai. "Numerical Study on Application Conditions of Equivalent Continuum Method for Modeling Heat Transfer in Fractured Geothermal Reservoirs." Processes 9, no. 6 (June 10, 2021): 1020. http://dx.doi.org/10.3390/pr9061020.
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The equivalent continuum method an effective approach for modeling heat transfer in fractured geothermal reservoirs. However, presently there is a lack of systematical and profound study on application conditions of the equivalent porous media (EPM) method. In this study, we numerically investigated the application conditions of the EPM method based on geological data of Yangbajing geothermal field. The results indicate that when fracture spacing is within 3–25 m, the results of the EPM method are basically in the same levels as those of the MINC method. However, when the fracture spacing is within 25–300 m, differences of the EPM method from the MINC method increase with the fracture spacing, so when the fracture spacing is within 25–300 m, it is unreasonable to adopt the EPM method to simulate the fractured reservoirs. With the fracture spacing increasing within 25–300 m, the system production temperature and electric power will gradually decrease; the injection pressure, reservoir impedance and pump power will gradually increase; and the energy efficiency will gradually decrease.
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Njoku, Chinedu J., William J. A. Saville, Stephen M. Reed, Michael J. Oglesbee, Päivi J. Rajala-Schultz, and Roger W. Stich. "Reduced Levels of Nitric Oxide Metabolites in Cerebrospinal Fluid Are Associated with Equine Protozoal Myeloencephalitis." Clinical and Vaccine Immunology 9, no. 3 (May 2002): 605–10. http://dx.doi.org/10.1128/cdli.9.3.605-610.2002.
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ABSTRACT Equine protozoal myeloencephalitis (EPM) is a disease of horses that is primarily associated with infection with the apicomplexan Sarcocystis neurona. Infection with this parasite alone is not sufficient to induce the disease, and the mechanism of neuropathogenesis associated with EPM has not been reported. Nitric oxide (NO) functions as a neurotransmitter, a vasodilator, and an immune effector and is produced in response to several parasitic protozoa. The purpose of this work was to determine if the concentration of NO metabolites (NO x −) in the cerebrospinal fluid (CSF) is correlated with the development of EPM. CSF NO x − levels were measured before and after transport-stressed, acclimated, or dexamethasone-treated horses (n = 3 per group) were experimentally infected with S. neurona sporocysts. CSF NO x − levels were also compared between horses that were diagnosed with EPM after natural infection with S. neurona and horses that did not have clinical signs of disease or that showed no evidence of infection with the parasite (n = 105). Among the experimentally infected animals, the mean CSF NO x − levels of the transport-stressed group, which had the most severe clinical signs, was reduced after infection, while these values were found to increase after infection in the remaining groups that had less severe signs of EPM. Under natural conditions, horses with EPM (n = 65) had a lower mean CSF NO x − concentration than clinically normal horses with antibodies (Abs) against S. neurona (n = 15) in CSF, and horses that developed ataxia (n = 81) had a significantly lower mean CSF NO x − concentration than horses that did not have neurologic signs (n = 24). In conclusion, lower CSF NO x − levels were associated with clinical EPM, suggesting that measurement of CSF NO x − levels could improve the accuracy of diagnostic tests that are based upon detection of S. neurona-specific Abs in CSF alone and that reduced NO levels could be causatively related to the development of EPM.
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Han, Peter K., and James L. White. "Rheological Studies of Dynamically Vulcanized and Mechanical Blends of Polypropylene and Ethylene-Propylene Rubber." Rubber Chemistry and Technology 68, no. 5 (November 1, 1995): 728–38. http://dx.doi.org/10.5254/1.3538769.
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Abstract An experimental study is presented of the rheological properties of (i) polypropylene, (ii) a commercial polypropylene/ethylene-propylene terpolymer a dynamically vulcanized blend (PP/EDPM-TPE) and (iii) a mechanical blend of a polypropylene and an ethylene-propylene copolymer. The polypropylene behaves as a typical flexible chain thermoplastic exhibiting a zero shear viscosity and higher shear rate non-Newtonian viscosity, well defined normal stresses, an elongational viscosity three times the zero shear viscosity, and an equality of the shear viscosity and the complex viscosity (Cox-Merz Rule). The PP/EPM-TPE exhibits an apparent yield value in shear flow, unmeasurable normal stresses and a complex viscosity which is much greater than the shear viscosity. This is behavior similar to that of particle filled compounds, block copolymers and liquid crystalline thermoplastics and suggests a material with a rest state structure. The behavior of the PP/EPM mechanical blend is intermediate.
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Kaneberg, Elvira. "Managing military involvement in emergency preparedness in developed countries." Journal of Humanitarian Logistics and Supply Chain Management 7, no. 3 (December 4, 2017): 350–74. http://dx.doi.org/10.1108/jhlscm-04-2017-0014.
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Purpose The purpose of this paper is to analyse supply chain network management (SCNM) in the context of emergency preparedness management (EPM). The results of this study revealed that civil-military relations are essential for EPM to function as a coordinated approach to safety and security, and are necessary to respond effectively to complex emergencies and mitigating threats to developed countries. Civil-military relations are still a concern in the context of communication, the exercise of authority, and the coordination of emergency supplies (ES) to emergency operations. Design/methodology/approach This qualitative study is based on field observations, with attention focused on the EPM of Sweden, Finland, and Poland. The analysis of a broader SCNM through EPM was supported by semi-structured interviews among civil-military actors in Sweden, information collected from informal conversations known as “hanging out”, and secondary materials. Empirically, the analysis included a variety of civil-military relationships and identified implications for management, policy, and planning that are applicable to developed countries. Findings The management of civil-military relations is a meaningful resource when used as an overall approach for safety and security. The integration of civil-military relations in EPM in the planning of ES is a long-standing and complex matter. The management of Swedish civil-military relations in EPM is recognising that implications for management are imbedded in continuous policy changes in, for example, the Swedish policy history. Civil-military relational complications that arise in the field of operations are impossible to anticipate during emergency planning, as those complications are grounded in policy changes. Originality/value Escalating threats to developed countries are highlighted. The study underlines the primary measures used in studying military involvement in EPM. An understanding of SCNM as a choice for management can be obtained in future research that focuses on a broader role of the military in EPM. Sweden has emphasised a clearer role for the military by reactivating total defence planning and by evolving common practices and processes with civil actors in civil defence. Meanwhile, Poland and Finland are increasing their focus on supporting the management of civil-military policies on safety and security regarding communication, authority, and developing coordination. Consistent with findings from previous reports on SCNM, civil-military relations are essential for EPM. This study confirmed the importance of civil-military coordination, the management and practice of authority, and shared forms of communication.
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Atuesta Venegas, María Del Rosario, Andrés Felipe Ceballos Moncada, and Rodrigo Gómez Alvis. "Co-creación como metodología para la apropiación social de la ciencia y la tecnología (ascyt) del recurso agua. Caso Urabá-Antioqueño-Colombia." Agora U.S.B. 16, no. 1 (January 6, 2016): 277. http://dx.doi.org/10.21500/16578031.2176.
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Este artículo, comparte el abordaje metodológico desarrollado por el programa “Experiencias Pedagógicas Itinerantes Museo del Agua EPM” apoyado por Colciencias y desarrollado por la Fundación Empresas Públicas de Medellín (EPM) y la Universidad EAFIT en Colombia, el cual implementó una estrategia de participación comunitaria centrada en procesos de co-creación, para llevar a comunidades alejadas del territorio antioqueño, opciones para desarrollar procesos de conocimiento, comprensión y relacionamiento con el recurso agua, basados en información científica y experiencias del Museo del Agua EPM en Colombia.
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Llinares, Alberto Zapatera. "Descriptores del Desarrollo de la Mirada Profesional en el Contexto de la Generalización de Patrones." Bolema: Boletim de Educação Matemática 33, no. 65 (December 2019): 1464–86. http://dx.doi.org/10.1590/1980-4415v33n65a23.
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Resumen El objetivo de esta investigación es generar descriptores del desarrollo de la competencia docente mirar profesionalmente el pensamiento matemático de los alumnos en estudiantes para maestro (EPM), en el contexto de la generalización de patrones. Para ello, se pidió a futuros maestros que describieran las respuestas de tres alumnos de Primaria a un problema de generalización de patrones, que interpretaran la comprensión de los alumnos y que propusieran acciones para mejorar o ampliar el proceso de enseñanza-aprendizaje. A partir de las destrezas que conceptualizan la mirada profesional (identificar, interpretar y decidir) se generaron descriptores de cuatro niveles de desarrollo: (1) EPM que no identifican los elementos matemáticos relevantes en el proceso de generalización de patrones, (2) EPM que identifican los elementos matemáticos, pero no los usan para interpretar la comprensión de los alumnos, (3) EPM que identifican los elementos y los usan para interpretar la comprensión de los alumnos y (4) EPM que identifican los elementos, los usan para interpretar la comprensión de los alumnos y proponer acciones adecuadas para el progreso del aprendizaje de los alumnos de Primaria. Los niveles establecidos y sus descriptores pueden ser el punto de partida para establecer una futura trayectoria de aprendizaje de la mirada profesional y ofrecer información a los formadores para interpretar el progreso de los EPM en el desarrollo de la competencia mirar profesionalmente el pensamiento matemático de los alumnos en el contexto de la generalización de patrones.
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Zhao, Ying Ge, Rui Qiong Tian, Jing Zhang, Xiao Yang Liang, and Qing Shang. "Fabrication of Eprinomectin-Loaded PLGA Microspheres and their In Vitro Veterinary Release Profiles." Advanced Materials Research 1120-1121 (July 2015): 807–12. http://dx.doi.org/10.4028/www.scientific.net/amr.1120-1121.807.
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To prolong the bioactivity of eprinomectin (EPM), a batch of EPM-loaded PLGA microspheres were fabricated by a solvent evaporation method. The morphology of resultant microspheres was observed with an S-4800-I scanning electron microscope (SEM). The EPM release behaviors were investigated with a dialysis method and fitted with Zero-order, First-order, and Higuchi dynamical models. The optimum formula, CPVA 2.0 w/v%, stirring rate 1, 200 r/min, CPLGA 4.0 wt%, and oil/water ratio 1/250, was obtained from single-factor experiments. SEM images suggested that the resultant microspheres were monodispersed spheres with a few micropores on their surfaces. Furthermore, more pores and hollows were observed in the degraded PLGA matrix. EPM-loaded PLGA microspheres showed the maximum release amount in the mixture of alcohol/PBS (4/6, v/v). The release process lasted for 30 d, which increased the bioactivity and insecticidal efficacy of EPM. Besides, microspheres with the diameter of 50 μm showed a better release behavior than those from 100 μm and 150 μm ones. Therefore, such method had a promising application on sustained release of veterinary medicine.
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Maciejewska, Magdalena. "Ionic Liquids and Calcium Oxide Grafted with Allylmalonic Acid Applied to Support the Peroxide Crosslinking of an Ethylene–Propylene Copolymer." Materials 13, no. 15 (July 22, 2020): 3260. http://dx.doi.org/10.3390/ma13153260.
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Nanosized calcium oxide (CaO) featuring a surface grafted with allylmalonic acid (ALA) was used to increase the efficiency of the peroxide crosslinking of an ethylene–propylene copolymer (EPM) filled with silica nanoparticles. In this study, 1-butyl-3-methylimidazolium ionic liquids (ILs) with different anions were applied to improve the dispersion of CaO/ALA and silica nanoparticles in the EPM copolymer, as well as to catalyze the interfacial crosslinking reactions. In this article, we discuss the effects of CaO/ALA and ILs on the curing characteristics, vulcanization temperature, crosslink density, mechanical properties, and thermal stability of EPM, as well as the resistance of EPM to weather aging. The CaO/ALA with ILs reduced the vulcanization time of the rubber compounds without a significant effect on the vulcanization temperature. Their application resulted in an increased vulcanizate crosslink density, as well as improved tensile strength compared to the pure peroxide system. The influence of 1-butyl-3-methylimidazolium ILs on EPM vulcanization and performance depends on the anion present in the molecules of the ionic liquid. The most active IL seems to be that with the tetrafluoroborate anion.
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Sypsas, Athanasios, and Dimitris Kalles. "Reviewing Process Mining Applications and Techniques in Education." International Journal of Artificial Intelligence & Applications 13, no. 1 (January 31, 2022): 83–102. http://dx.doi.org/10.5121/ijaia.2022.13106.
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Process Mining (PM) emerged from business process management but has recently been applied to educational data and has been found to facilitate the understanding of the educational process. Educational Process Mining (EPM) bridges the gap between process analysis and data analysis, based on the techniques of model discovery, conformance checking and extension of existing process models. We present a systematic review of the recent and current status of research in the EPM domain, focusing on application domains, techniques, tools and models, to highlight the use of EPM in comprehending and improving educational processes.
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Spencer, Jennifer A., Patricia Deinnocentes, Edith M. Moyana, Anthony J. Guarino, Siobhan E. Ellison, R. Curtis Bird, and Byron L. Blagburn. "Cytokine Gene Expression in Response to SnSAG1 in Horses with Equine Protozoal Myeloencephalitis." Clinical Diagnostic Laboratory Immunology 12, no. 5 (May 2005): 644–46. http://dx.doi.org/10.1128/cdli.12.5.644-646.2005.
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ABSTRACT Equine protozoal myeloencephalitis (EPM) is a neurologic syndrome seen in horses from the Americas and is mainly caused by Sarcocystis neurona. Recently, a 29-kDa surface antigen from S. neurona merozoites was identified as being highly immunodominant on a Western blot. This antigen has been sequenced and cloned, and the expressed protein has been named SnSAG1. In a previous study, cell-mediated immune responses to SnSAG1 were shown to be statistically significantly reduced in horses with EPM in comparison to EPM-negative control horses. It therefore appears as though the parasite is able to induce immunosuppression towards parasite-derived antigens as parasite-specific responses are decreased. Isolated peripheral blood lymphocytes from 21 EPM (cerebrospinal fluid [CSF] Western blot)-negative horses with no clinical signs and 21 horses with clinical signs of EPM (CSF Western blot positive) were cocultured with SnSAG1 for 48 and 72 h, and the effect on cytokine production was investigated by means of reverse transcriptase PCR. Cytokines assayed include gamma interferon (IFN-γ), tumor necrosis factor alpha, interleukin (IL)-2, IL-4, and IL-6. β-Actin was used as the housekeeping gene. A Wilcoxon signed-rank test of the findings indicated that there was a statistically significant decrease in IFN-γ production after 48 h in culture for samples from horses with clinical disease. There was also a statistically significant increase in IL-4 production after 72 h in culture for samples from horses with EPM. These results further support the notion that this parasite is able to subvert the immune system in horses with clinical disease.
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Carvalho, Milene C., Caio M. Moreira, Janaína M. Zanoveli, and Marcus L. Brandão. "Central, but not basolateral, amygdala involvement in the anxiolytic-like effects of midazolam in rats in the elevated plus maze." Journal of Psychopharmacology 26, no. 4 (December 8, 2010): 543–54. http://dx.doi.org/10.1177/0269881110389209.
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The role of the amygdala in the mediation of fear and anxiety has been extensively investigated. However, how the amygdala functions during the organization of the anxiety-like behaviors generated in the elevated plus maze (EPM) is still under investigation. The basolateral (BLA) and the central (CeA) nuclei are the main input and output stations of the amygdala. In the present study, we ethopharmacologically analyzed the behavior of rats subjected to the EPM and the tissue content of the monoamines dopamine (DA) and serotonin (5-HT) and their metabolites in the nucleus accumbens (NAc), dorsal hippocampus (DH), and dorsal striatum (DS) of animals injected with saline or midazolam (20 and 30 nmol/0.2 µL) into the BLA or CeA. Injections of midazolam into the CeA, but not BLA, caused clear anxiolytic-like effects in the EPM. These treatments did not cause significant changes in 5-HT or DA contents in the NAc, DH, or DS of animals tested in the EPM. The data suggest that the anxiolytic-like effects of midazolam in the EPM also appear to rely on GABA-benzodiazepine mechanisms in the CeA, but not BLA, and do not appear to depend on 5-HT and DA mechanisms prevalent in limbic structures.
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Moholkar, Disha Nagesh, Raghuram Kandimalla, Farrukh Aqil, and Ramesh Gupta. "Abstract 372: Biodistribution and tumor targeting of exosomes using mouse models." Cancer Research 82, no. 12_Supplement (June 15, 2022): 372. http://dx.doi.org/10.1158/1538-7445.am2022-372.
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Abstract Biodistribution studies are relevant models for understanding the fundamental preclinical information of the distribution of drugs to the potential target organs, which provide insight on which on-target or off-target effects might be expected. One of our research focuses is the study of uptake and distribution of bovine milk- and colostrum-derived exosomes, functionalized exosomes and exosomes in polyethyleneimine (PEI) matrix (EPM) using near-infrared fluorescent dye in rodents. Previously, when DiR dye was loaded onto milk exosomes, biodistribution studies showed that route of administration had a significant influence on the tissue distribution with somewhat uniform biodistribution with oral gavage while predominated liver accumulation with the i.v. route. In this study, we show biodistribution of colostrum exosomes, EPM and tumor targeting by attaching tumor targeting ligand, folic acid (FA). We studied the biodistribution of these formulations using exosomes labeled with Alexa Fluor 750 (AF750) in wild-type mice and subcutaneous lung tumor-bearing mice. In various studies we tested: i) biodistribution of exosomes vs EPM, ii) effect of different administration routes such as intravenous (i.v.), oral (p.o.), subcutaneous (s.c.), intranasal (i.n.) and intramuscular (i.m.) on biodistribution, and iii) tumor targeting using FA-functionalized exosomes and EPM. Uniform tissue distribution was observed upon oral administration of exosomes while predominant hepatic accumulation was observed with i.v. administration. The i.n. route resulted in pre-dominant accumulation in lung, whereas i.m. and s.c. delivery had almost similar distribution as observed with i.v. route. The distribution of exosomes and EPM matrix was largely similar. We observed that the fluorescent signals from AF750-labeled FA-Exo and FA-EPM treatment revealed higher tumor accumulation of exosomes as compared to non-functionalized exosomes and EPM, respectively due to overexpression of folate receptors. Time-dependent distribution showed accumulation of EPM in tumors at later time point. The EPM formulations could be detected at the sites otherwise difficult to target such as brain and lymph nodes after systemic administration, thus indicating suitability of these formulations to cross physiological barriers. To validate the therapeutic potential, FA-EPM was loaded with 15 μg siKRAS and injected intravenously to orthotopic A549 lung tumor-bearing mice. Significant reduction in tumor volume (67%; p <0.001) and tumor weight (76%; p <0.001) was observed which corroborated the significant knockdown of KRAS protein (p <0.01). Thus, this novel approach can be used as a nano ‘platform’ for drug delivery due to its increased circulating half-life, high uptake by target cells, and ability to load a diverse range of pharmaceutical therapeutics including biologics such as siRNA. (Supported from Duggan Endowment and 3P biotechnologies, Inc.) Citation Format: Disha Nagesh Moholkar, Raghuram Kandimalla, Farrukh Aqil, Ramesh Gupta. Biodistribution and tumor targeting of exosomes using mouse models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 372.
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Chen, Yue, Kaiyu Feng, Gao Cong, and Han Mao Kiah. "Example-based spatial pattern matching." Proceedings of the VLDB Endowment 15, no. 11 (July 2022): 2572–84. http://dx.doi.org/10.14778/3551793.3551815.
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The prevalence of GPS-enabled mobile devices and location-based services yield massive volume of spatial objects where each object contains information including geographical location, name, address, category and other attributes. This paper introduces a novel type of query termed example-based spatial pattern matching (EPM) query. It takes as input a set of spatial objects, each of which is associated with one or more keywords and a location. These objects serve as an example that depicts the spatial pattern that users want to retrieve. The EPM query returns all sets of objects that match the spatial pattern. The EPM query can be used for applications like urban planning, scene recognition and similar region search. We propose an efficient algorithm and three pruning techniques to answer EPM queries. Furthermore, we provide an approximation guarantee for intermediate results of the algorithm. Our experimental evaluations on four real-world datasets demonstrate the effectiveness and efficiency of our proposed algorithm and techniques.
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Nurahayu, Choirunnisa, Evi Yuniarti, and Nurmala Nurmala. "Analisis Model Prediksi Kebangkrutan Altman Z-Score. Springate dan Zmijewski untuk Menilai Kelangsungan Usaha PT Enseval Putera Megatrading Tbk." Jurnal Ilmiah ESAI 12, no. 2 (July 23, 2018): 128–32. http://dx.doi.org/10.25181/esai.v12i2.1101.
Full textAbstract:
The economic development of PT EPM Tbk in 2011 to 2016 did not improved, because in 2011 to 2016 the cash flow statement of PT EPM Tbk. decreased. This writing aims to determine the prediction of bankruptcy at PT EPM Tbk with the Altman Z-Score, Springate and Zmijewski Score models to assess the business continuity of PT EPM Tbk from 2011 to 2016. The analysis technique used is the Altman Z-Score bankruptcy prediction model, Springate and the Zmijewski Score for various types of companies. Based on the results of the analysis of the three bankruptcy prediction models Altman Z-Score, Springate Score and Zmijewski Score shows that the business continuity assessment of PT Enseval Putera Megatrading Tbk in 2011 to 2016 is a company in good financial condition or a healthy company and is not at risk The Z-Score is more than the Altman Z-Score, Springate Score and Zmijewski Score standards.Keywords: Altman Z-Score, Springate Score, Zmijewski Score and Business Continuity
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Nurahayu, Choirunnisa, Evi Yuniarti, and Nurmala Nurmala. "Analisis Model Prediksi Kebangkrutan Altman Z-Score. Springate dan Zmijewski untuk Menilai Kelangsungan Usaha PT Enseval Putera Megatrading Tbk." Jurnal Ilmiah Esai 12, no. 2 (December 18, 2018): 128. http://dx.doi.org/10.25181/esai.v12i2.1129.
Full textAbstract:
The economic development of PT EPM Tbk in 2011 to 2016 did not improved, because in 2011 to 2016 the cash flow statement of PT EPM Tbk. decreased. This writing aims to determine the prediction of bankruptcy at PT EPM Tbk with the Altman Z-Score, Springate and Zmijewski Score models to assess the business continuity of PT EPM Tbk from 2011 to 2016. The analysis technique used is the Altman Z-Score bankruptcy prediction model, Springate and the Zmijewski Score for various types of companies. Based on the results of the analysis of the three bankruptcy prediction models Altman Z-Score, Springate Score and Zmijewski Score shows that the business continuity assessment of PT Enseval Putera Megatrading Tbk in 2011 to 2016 is a company in good financial condition or a healthy company and is not at risk The Z-Score is more than the Altman Z-Score, Springate Score and Zmijewski Score standards.
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Васильев, М. В., and Э. И. Ягудина. "Российская эфемерида Луны EPM-ERA 2012." Астрономический вестник 48, no. 2 (2014): 169–76. http://dx.doi.org/10.7868/s0320930x14020078.
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Tshernyshev, W. B. "Ecological pest management (EPM): general approaches." Journal of Applied Entomology 119, no. 1-5 (January 12, 1995): 379–81. http://dx.doi.org/10.1111/j.1439-0418.1995.tb01304.x.
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Vasilyev, M. V., and E. I. Yagudina. "Russian lunar ephemeris EPM-ERA 2012." Solar System Research 48, no. 2 (March 2014): 158–65. http://dx.doi.org/10.1134/s0038094614020075.
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