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Saville, William James Allan. "The epidemiology of equine protozoal myeloencephalitis (EPM)." Connect to resource, 1998. http://rave.ohiolink.edu/etdc/view.cgi?acc%5Fnum=osu1243352811.
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Ciscato, Dario. "Innovative industrial applications of EPM (Electromagnetic Processing of Materials)." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3421652.
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This PhD thesis presents an overview of the most recent industrial applications of the EPM (Electromagnetic Processing of Materials) going into details on the directional solidification processes in TiAl alloys and silicon for photovoltaic applications.
The design and realization of an induction DSS prototype is presented.Dopo un'ampia panoramica sulle applicazioni industriali più recenti dell'EPM (Electromagnetic Processing of Materials) questa tesi di dottorato approfondisce i processi di solidificazione direzionale di leghe di TiAl e del silicio per il fotovoltaico. Una intera sezione è dedicata alla progettazione e realizzazione di un prototipo di forno DSS ad induzione.
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Nedzelský, Roman. "Implementace systému EPM 2010 pro podporu výuky řízení projektů a portfolia." Master's thesis, Vysoká škola ekonomická v Praze, 2011. http://www.nusl.cz/ntk/nusl-124722.
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This thesis deals with the issue of the project management, project portfolio management and environment settings for the management and portfolio analysis in a fictional organization. In the theoretical introduction there is outlined the situation of the education of the project portfolio management at universities in the Czech Republic, Europe and worldwide, in summary form of founded courses that deal with this issue. Some basic principles of PMI methodology follow to introduce the reader to the project and portfolio management. As a practical part of this thesis there has been project management solution software implemented as a support for the portfolio management education. Microsoft Project 2010 has been selected for this purpose. This part of the thesis guides reader through practical topics like how to set up the whole environment including all utilities and contains a description of services settings. As example there were also sample roles and resources of the company set up, which were subsequently assigned to fictional projects so that the business portfolio analysis based on set of business goals and prioritization of individual projects could have been performed. The contribution of this work can be found mainly in the possibility of portfolio management education and training by using one of the leading software tool that are successfully implemented in a real production environment, and to try out the various acts and practices and also to clarify the various processes in the context of specific projects within the portfolio. Prepared fictional organization and sample data can be especially used as a model for handling various assignments in the upcoming educational courses at VŠE.
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Civiero, Enrico <1997>. "CI&LO: an operative approach to improve EPM in companies." Master's Degree Thesis, Università Ca' Foscari Venezia, 2022. http://hdl.handle.net/10579/21845.
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L’avanzare della digitalizzazione spinge le organizzazioni a rileggere il vantaggio competitivo in termini di migliore elaborazione dei dati, cioè nell’affrontare sfide combinando molteplici prospettive per costruire informazioni diverse, con cui poi formulare proposte di valore altrettanto differenti. I sistemi di Enterprise Performance Management costituiscono uno strumento imprescindibile per sviluppare quella maggiore flessibilità che, alcune teorie di Data Governance associano proprio alla capacità di “navigare i dati”, cioè di gestirne le varie dimensioni.
Il seguente elaborato riprende le dinamiche appena descritte dando risalto all’approccio operativo che ho potuto sperimentare durante il mio tirocinio presso PwC Italia, come membro del Team CI&LO.
Il primo capitolo descrive innanzitutto il concetto di Continuous Improvement & Long-term Operations nel supporto ai sistemi EPM, con particolare riferimento alle logiche di intervento che ne derivano per l’omonimo Team e ai vantaggi dell’offrire tale servizio, oltre a tracciarne una dimensione quantitativa.
Il secondo capitolo si concentra invece sull’analisi degli interventi eseguiti al sistema EPM di una società attiva nel settore fashion che si è affidata al Team CI&LO, per presentare elementi a conferma di quanto descritto nel capitolo precedente.
Infine, nella parte conclusiva l’attenzione si sposta verso le metriche usate per valutare l’impatto di tali interventi ed il riscontro presso le aziende clienti, cercando di evidenziare ulteriormente le implicazioni che una simile impostazione di servizio può avere sulle attività di consulenza.
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Hay, Alayna Nicole. "Equine Protozoal Myeloencephalitis: investigating immunopathogenesis and treatment efficacy in mouse models and clinically affected horses." Diss., Virginia Tech, 2020. http://hdl.handle.net/10919/96373.
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Equine protozoal myeloencephalitis (EPM), predominantly caused by the protozoa Saracocystis neurona, is a common neurologic disease in horses from North America. Equine exposure to the parasite occurs frequently as the protozoa is excreted in opossum (Didelphis virginiana) feces and contaminates the horse's environment. However, clinical neurologic disease only emerges in a small fraction of exposed horses. The seemingly protective immune response that develops in some exposed horses but not all is not fully defined. Previous reports utilizing horse EPM models and immune compromised mouse models, which develop disease simulating EPM after infection with S. neurona, have reported a role of T-lymphocytes and the cytokine interferon gamma, in disease protection. As part of this dissertation, the role of T-lymphocytes and IFNγ was further elucidated. It was determined that IFNγ production is essential for T-lymphocytes to offer protection against S. neurona induced encephalitis, in immune compromised mice. Another factor hindering prognosis of EPM affected horses is treatment failure. The efficacy of the antiprotozoal decoquinate, was tested and found to be ineffective at preventing S. neurona encephalitis, in immune compromised mice. However, the antiprotozoal, diclazuril, was found to be effective at preventing S. neurona encephalitis in immunocompromised mice but once treatment was terminated, infection persisted, and neurologic disease developed. In-situ methods were employed to extensively evaluate the immunopathology of spinal cord tissue samples collected from EPM affected horses. A novel in-situ hybridization technique was successfully utilized to identify S. neurona in tissue samples collected from horses with EPM. This technique will create new opportunities for investigating the immunopathology of EPM. Overall results from the studies conducted in this dissertation suggest that IFNγ production from T lymphocytes is essential for them to offer protection against S. neurona encephalitis. Additionally, further insight on FDA approved and non-FDA approved treatment options for S. neurona infection was gained through the use of the B6Ifnγ -/- mouse model. Collectively, these studies expanded on the knowledge of an understudied equine neurologic disease.Doctor of Philosophy
Horses are susceptible to the neurologic disease Equine Protozoal Myeloencephalitis, more commonly referred to as EPM by equine enthusiasts. The disease results from ingestion of the parasite, Saracocystis neurona, which contaminates the horse's natural environment; therefore, horses are likely to come in contact with the parasite while eating or drinking. Not all horses that encounter S. neurona develop neurologic disease, some will be protected by their immune system with the only evidence of exposure being serological antibodies. In efforts to not experimentally induce EPM in horses, an immunocompromised mouse model is often used instead. Through the use of the immunocompromised mouse model, researchers have discovered that the immune cell, T lymphocytes, and signaling molecule, interferon gamma, are important for protection against S. neurona infection. In one study conducted for this dissertation it was found that T lymphocytes need to be able to produce interferon gamma in order to provide protection. Another issue that the immunocompromised mouse model has helped address, is EPM treatment efficacy. The inability of antiprotozoal drugs that are utilized for EPM treatment to fully eliminate the parasite from the horse's body is thought to cause reoccurring disease in some horses. One non-FDA approved treatment was evaluated here and determined not to be effective in the immunocompromised mouse model. One FDA approved treatment option, which is commonly used to treat EPM, was evaluated as well. This drug was proven to be effective at preventing disease while mice were being treated but termination of treatment led to development of neurologic disease, exemplifying treatment failure. One final study was conducted to examine the different types of immune cells and signaling molecules in spinal cord tissue samples collected, from horses which had to be euthanized due to poor prognosis related to EPM. In this study a novel experimental technique was successfully used which will help progress EPM research. Overall results of these studies offered more explanation on the immune response that protects against neurologic disease from S. neurona infection and demonstrated that not all treatments are effective and reoccurring disease may be a result of treatment failure.
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Fernandes, Luiz Gustavo da Costa. "Análise da implementação do Enterprise Project Management (EPM) em uma empresa de engenharia." Universidade Federal Fluminense, 2017. https://app.uff.br/riuff/handle/1/5260.
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A necessidade de modernização dos processos de trabalho conduziu as empresas na busca por ferramentas que atendessem mais eficientemente aos seus objetivos. Neste contexto, surge o software de gerenciamento de projetos Enterprise Project Management – EPM (versão 2010) da Microsoft, que garante adequados planejamento, organização, monitoramento, controle e avaliação de um projeto, além de facilitar a comunicação entre os stakeholders e antever falhas e problemas de projeto. Deste modo, o presente estudo possui como objetivo analisar os impactos positivos e negativos da implementação do EPM em uma empresa de Engenharia. Esta pesquisa possui abordagem qualitativa, exploratória, utilizando o estudo de caso como método para investigação prática, cujos dados foram coletados por meio de aplicação eletrônica, por e-mail, de questionário on-line específico para os 27 respondentes que integraram o estudo. Quanto ao cenário, trata-se de uma empresa de engenharia responsável por analisar tecnicamente documentos relacionados a plataformas de extração de petróleo. Os dados foram analisados por meio de frequência simples, para as perguntas fechadas, e por meio de análise de conteúdo das perguntas abertas. Os temas foram agrupados e compuseram duas categorias de análises de dados. Assim, foram identificados como aspectos positivos: melhoria no gerenciamento dos recursos; melhoria dos controles dos projetos; centralização de informações, melhoria no planejamento dos projetos e inexistência de malefícios. Os principais aspectos negativos citados foram: Custo de overhead, limitação da ferramenta para projetos grandes e complexos, falta de centralização de algumas funcionalidades e usabilidade do sistema. O estudo concluiu que existem oportunidades de melhorias para a utilização da ferramenta por meio de treinamentos pontuais voltados para todos os integrantes da equipe, de acordo com a especificidade de cada perfil de atuação. Desta forma, será possível usufruir das possibilidades de aplicação da ferramenta por todos os envolvidos, bem como identificar falhas ou práticas inadequadas nos projetos.
The need for modernization of work processes led companies to the search for tools that achieve more effectively their objectives. In this context, the project management software (version 2010) from Microsoft named Enterprise Project Management arises, which ensures proper planning, organization, monitoring, control and evaluation of a project, in addition to facilitating communication among the stakeholders and anticipating project failures and problems. Thus, the present study has as its object the implementation of Enterprise Project Management (EPM) software, version 2010, and as a general objective the evaluation of the positive and negative impacts of the EPM implementation on an Engineering company. This research has a qualitative and exploratory approach such as a case study whose data was collected from a specific online questionnaire sent via e-mail to 27 respondents who participated in the study. Regarding the setting, it is an engineering company responsible for technically analyzing documents related to oil rigs. Data was analyzed through simple frequency for closed questions and through context analysis for open questions. The themes were grouped and composed of two categories of data analysis. So, the positive aspects that have been identified were as follows: resources management improvement; projects controls improvement; centralization of information, projects planning improvement and non-existence of shortcomings. The main negative aspects mentioned were as follows: overhead costs, tool limitation for big and complex projects, lack of centralization of some functionalities and system usability. The study has concluded that there are opportunities of improving the tool usage through providing training to all main stakeholders, according to the specificity of each profile acting in the projects. Thus, it will be possible to take advantage of all possibilities of applying the tool by all the involved parties as well as identifying failures or inappropriate practices in the projects.
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Dryburgh, Elizabeth Lila. "IDENTIFICATION OF DIFFERING STRAINS OF SARCOCYSTIS NEURONA MEROZOITES." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1354712574.
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Günther, Edeltraud, Wolfgang Uhr, Susann Kaulich, Lilly Scheibe, Claudia Heidsieck, and Jürgen Fröhlich. "Von der Konzeption zum EPM-KOMPAS: Umsetzung der Umweltleistungsmessung mit kleinen und mittleren Unternehmen." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2003. http://nbn-resolving.de/urn:nbn:de:swb:14-1059054546156-50028.
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Dieser Bericht ist einzuordnen in das zweite Projektjahr des laufenden Forschungsprojektes EPM-KOMPAS und die bisherigen Dokumentationen über dessen Projektfortschritte. Gerade die intensive Kooperation und die Diskussionen mit den Projektunternehmen erbrachten konstruktive und anwendungsorientierte Kritik und Anforderungen an das EPM-Instrument. Daraus resultieren eine Reihe von Modifizierungen, die in Form von Prototypen in der Praxis Abgleich finden und dargestellt werden. Jedoch ist die Entwicklung des Prototypen und seine Weiterentwicklung kontinuierlich von den Impulsen aus der Praxisarbeit beeinflusst und in einem ständigen Prozess. Der akutelle Forschungs- und Projektstand soll daher skizziert werden.
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Carvalho, Cristiane dos Santos. "Os elementos da performance musical (EPM) na preparação de recitais de grupos de flautas doce." Universidade Federal de Goiás, 2016. http://repositorio.bc.ufg.br/tede/handle/tede/6122.
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Fundação de Amparo à Pesquisa do Estado de Goiás - FAPEG
The Final Product of Masters Degree presented here consists of two required parts: Part A (Artistic Production) and Part B (Scientific Production). The artistic part is composed of concerts presented throughout the process, including the defense recital, directly related to the developed research. The scientific part consists of an article that addresses the preparation of Brazilian recorder‟s ensembles at universities from the perspective of Musical Performance Elements (MPE) concept used as a focus of the research that was developed by RAY (2005). The main objective of the research was to identify the recorder active groups in universities, know how they work and indicate ways to optimize the preparation of this kind of group. The adopted methodological procedure was literature review on the subject and field research to identify the recorder active ensembles in Brazilian universities, followed by the organization and discussion of results. At last, we used the material gathered and discussed as a basis for the development of suggestions for the preparation of recitals in recorder‟s ensemble.
O Produto Final de conclusão de Mestrado aqui apresentado é composto de duas partes obrigatórias: Parte A (Produção Artística) e Parte B (Produção Científica). A parte artística é composta pelos recitais apresentados ao longo do curso, incluindo o recital de defesa, diretamente relacionado com a pesquisa desenvolvida. A parte científica é constituída por um artigo que aborda o processo de preparação de grupos de flautas doces de universidades brasileiras sob a ótica dos Elementos da Performance Musical (EPM), conceito utilizado como foco da pesquisa que foi desenvolvido por RAY (2005). O objetivo principal da pesquisa foi identificar os grupos de flautas doces ativos em universidades, entender como eles funcionam e indicar formas de otimizar a preparação deste tipo de grupo. O procedimento metodológico adotado foi revisão de literatura sobre o tema e pesquisa de campo para identificação dos grupos de flautas doces ativos em universidades brasileiras, seguidos da organização e discussão dos resultados. Ao final, utiliza-se do material reunido e discutido como base para a elaboração de sugestões para a preparação de recitais em grupos de flautas doces.
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Dini, Gal Moreira [UNIFESP]. "Validade de construção e sensibilidade da escala de auto-estima Rosemberg/UNIFESP-EPM em lipoaspiração." Universidade Federal de São Paulo (UNIFESP), 2004. http://repositorio.unifesp.br/handle/11600/18855.
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Previous issue date: 2004Introdução: Sentimentos conscientes e inconscientes sobre o corpo possuem uma importante forca psicologica. A cirurgia plastica pode alterar a aparencia de seus pacientes e, deste modo, alterar nao so o contorno corporal como a auto-imagem e auto-estima. Com a evolucao das Ciências ligadas a area da Saúde, surgem cada vez mais opcoes de tratamentos. Nos ultimos anos, questionarios de medida de qualidade de vida vem sendo largamente utilizados numa escala mundial, incluindo estudos internacionais multicentricos. A escala de Rosenberg e um instrumento desenvolvido nos Estados Unidos da America para avaliar um aspecto da qualidade de vida, que e a auto-estima. Esse aspecto, por estar associado a auto-imagem. parece ser uma medida interessante para avaliar resultado em cirurgia plastica. Para compararmos dados obtidos em estudos semelhantes realizados em populacoes cultural e linguisticamente distintas, e necessaria a padronizacao dos processos de traducao, adaptacao cultural e o teste de suas propriedades de medida (validade, reprodutibilidade e sensibilidade). Esse rigor metodologico assegura a uniformidade dos dados obtidos. Objetivos: Este trabalho tem como objetivo testar a validade de construcao e a sensibilidade responsividade da Escala de auto-estima Rosenberg UNIFESP/EPM em pacientes submetidos a lipoaspiracao. Material e Metodos: Foram operados 54 pacientes de ambos os sexos, com idade media de 28 anos. Estes apresentavam aumento do tecido adiposo no abdome [paciente tipo I (Pitanguy 2000)], associado ou nao a depositos localizados em outras regioes e manifestaram desejo da melhora estetica do contorno corporal. Foram aplicados 3 questionarios de avaliacao de qualidade de vida (Rosenberg - UNIFESP-EPM, Short Form-36, SRQ-20) antes e 6 meses apos o procedimento cirurgico. Resultados: Verifica-se que a lipoaspiracao melhorou as medias das seguintes dimensoes do questionario generico de qualidade de vida Short Form-36: Aspectos emocionais. Aspectos sociais, Saúde mental, Vitalidade, Capacidade funcional, Aspectos fisicos e Estado geral de Saúde. Houve diminuicao das medias para os instrumentos: Escala de Auto-estima Rosenberg - UNIFESP-EPM e SRQ-20. Sendo estas escalas inversas, apontou-se a melhora na qualidade de vida destes pacientes. A regressao demonstrou que 73,2 por cento da variabilidade da Escala de auto-estima foi explicada pelas dimensoes: SRQ-20 e Saúde Mental. Conclusao: A escala de auto-estima de Rosenberg/ UNIFESP-EPM apresentou validade de construcao e bons indices de sensibilidade responsividade em nosso meio
BV UNIFESP: Teses e dissertações
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Piccolo, Monica Sarto [UNIFESP]. "Burn Sexuality Questionnaire - tradução para a língua portuguesa, adaptação cultural e validação: BurnSexQ-EPM/Unifesp." Universidade Federal de São Paulo (UNIFESP), 2012. http://repositorio.unifesp.br/handle/11600/22308.
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Previous issue date: 2012Introdução: Na avaliacao da qualidade de vida de vitimas de queimadura, instrumentos confiaveis sao essenciais. Uma extensa revisao de literatura revelou que a atencao a sexualidade de pacientes com queimadura, raramente e foco desses estudos. O Burn Sexuality Questionnaire (BSQ), instrumento especifico, e unico em avaliar a sexualidade no contexto da qualidade de vida da vitima de queimadura. Constituido de 24 itens, 17 avaliam o comportamento do queimado quanto a imagem corporal e conforto social. OBJETIVOS: Traduzir o BSQ para a lingua portuguesa, adapta-lo culturalmente no Brasil e testar a reprodutibilidade, confiabilidade e validade de face conteudo e de construto. METODOS: Seguindo metodologia de GUILLEMIN, BOMBARDIER, BEATON (1993), o questionario foi traduzido para o portugues, adaptado culturalmente e testado em relacao a reprodutibilidade, validade de face, conteudo e construto. A versao traduzida foi aplicada em 80 pacientes brasileiros, sobreviventes de queimadura. RESULTADOS: A consistencia interna foi testada pelo alfa de Cronbach (0,87). A correlacao linear de Person foi significativa nos tres momentos das entrevistas na analise da reprodutibilidade. Realizou-se a validacao de construto correlacionando o BSQ com o questionario Burn Specific Health Scale-Revised (BSHS-R). Observou-se correlacao significativa entre o dominio Conforto Social do BSQ com os dominios Afeto e Imagem Corporal (p=0,025), Habilidades para Funcoes Simples (p=0,008), Trabalho (p=0,016) e Tratamento (p=0,037) do questionario BSHS-R. Este instrumento foi denominado BurnSexQ-EPM/UNIFESP. CONCLUSAO: O BSQ foi traduzido para o portugues e adaptado culturalmente no Brasil. E instrumento reprodutivel, apresenta validade global de face, de conteudo e validade de construto para o dominio Conforto Social
INTRODUCTION: In measuring the quality of life of burn victims, it is essential that we find reliable and valid means. An extensive literature review reveals that sexuality concerns of patient with burns are rarely a focus. The Burn Sexuality Questionnaire (BSQ) is a specific instrument; the only to assess sexuality in the context of burn victim quality of life. It is a 24-item questionnaire, which 17 of then assesses behavioral components of body image and social comfort among burn survivors. OBJECTIVE: The aim of this study is to translate and culturally adapt the BSQ into Brazilian Portuguese, assess reliability, face, content and construct validity. METHODS: After translation and cultural adaptation, we tested the final version for reliability and for face, content and construct validities, according to standard procedures. The Portuguese version was applied to 80 Brazilians burn survivors. RESULTS: Internal consistency was determined by calculating Cronbach’s alpha. Total Cronbach’s alpha was 0.87. Pearson’s correlation was significant between scores for different time points. Construct validity was demonstrated with the correlation of the BSQ with Burn Specific Health Scale-Revised (BSHS-R) questionnaire. It showed significant correlation between the BSQ social comfort domain and the BSHS-R affect and body image (p=0.025), simple function ability (p=0.008), work (p=0.016), and treatment (p=0.037) domains. It was denominated BurnSexQEPM/UNIFESP. CONCLUSIONS: The BSQ was translated and cultural adapted into Brazilian Portuguese. It is a reliable tool with global face and content validity; and it has construct validity for the social comfort domain. KEY WORDS: Health questionnaires, Outcome measures, Burn, Sexuality, Cross-Cultural Adaptation.
BV UNIFESP: Teses e dissertações
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Günther, Edeltraud, Wolfgang Uhr, Susann Kaulich, and (Hrsg ). Claudia Heidsieck. "Konzeptionelle Grundsätze der Umweltleistungsmessung in kleinen und mittleren Unternehmen: Zwischenbericht des Forschungsvorhabens EPM-KOMPAS Juni 2002." Technische Universität Dresden, 2002. https://tud.qucosa.de/id/qucosa%3A24152.
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Im betrieblichen Umweltmanagement wird heute nach den tatsächlichen Ergebnissen eines Umweltmanagementsystems sowie nach konsistenten Kriterien zur deren Messung, Bewertung und Beurteilung gefragt. Dem Ausspruch Galileo Galilei's "Messen, was messbar ist - Messbar machen, was nicht messbar ist" folgend, soll durch das vom Bundesministerium für Bildung und Forschung (BMBF) im Förderschwerpunkt "Betriebliche Instrumente für nachhaltiges Wirtschaften (Ina)" geförderte Forschungsprojekt der TU Dresden "Environmental Performance Measurement als Instrument für nachhaltiges Wirtschaften (EPM-KOMPAS)" die Umweltleistungsmessung in deutschen Unternehmen eingeführt werden. Im Vordergrund steht die Entwicklung eines Controllinginstruments zur internen Steuerung der Umweltleistung und die praktische Umsetzung der Umweltleistungsmessung mit Hilfe eines Software-Tools. Die anwendungsorientierte Weiterentwicklung dieses Werkzeuges, bei dem bereits die notwendige Datenverfügbarkeit empirisch validiert wurde, wird in Kooperation mit Unternehmen aus der Maschinenbaubranche erfolgen. Dabei liegt der Fokus bei der Messung der Umweltleistung der einzelnen Unternehmen auf der · Identifikation von Verursachungsgrößen (Performance Drivers) der Umweltleistung und · der Verknüpfung der ökologieorientierten Steuerung mit im Unternehmen vorhandenen betriebswirtschaftlichen Konzepten. Die Steuerung der Umweltleistung erfordert eine Aufspaltung in ihre einzelnen Erfolgskomponenten. Nur so können die Verursachungsgrößen identifiziert werden, die die Entscheidungsträger effektiv und zukünftig beeinflussen sollen.
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Parenti, Filho Antonio [UNIFESP]. "Escala de Auto-Estima Rosenberg-UNIFESP/EPM, Oral Health Impact Profile em idosos com overdentures mandibulares." Universidade Federal de São Paulo (UNIFESP), 2010. http://repositorio.unifesp.br/handle/11600/9469.
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Previous issue date: 2010-11-24INTRODUÇÃO: O advento da implantodontia tem possibilitado o sucesso das reabilitações orais, na obtenção de melhor estabilidade, retenção, conforto, estética, fonética, capacidade funcional e do bem-estar, com conseqüente longevidade da saúde bucal. Os questionários validados de qualidade de vida demonstram ser cada vez mais indispensáveis e capazes de mensurar, de forma quantitativa, a qualidade de vida com teor científico, por intermédio de dados estatísticos. OBJETIVO: Avaliar a qualidade de vida e a autoestima, em pacientes idosos que substituíram as próteses totais convencionais por overdentures mandibulares. MÉTODOS: Vinte e sete pacientes (15 grupo estudo e 12 grupo controle) utilizaram overdentures mandibulares e foram avaliados com questionários autoaplicáveis e assistidos: SF-36; OHIP-49; Escala de Auto-Estima Rosenberg-UNIFESP/EPM. RESULTADOS: Nos testes não paramétricos foram observadas diferenças estatísticas: OHIP-49 (Wilcoxon), grupo estudo, nos domínios: limitação funcional (p=0,010), dor física (p=0,020), incapacidade física (p=0,021), e incapacidade psicológica (p=0,040). OHIP-49 (Mann-Whitney), 2ªfase, nos domínios: limitação funcional (p<0,001), dor física (p=0,014), desconforto psicológico (p=0,005), incapacidade física (p=0,022), incapacidade psicológica (p=0,007), incapacidade social (p=0,031), deficiência (p=0,018), e p total (p=0,001). Não foram observadas diferenças estatísticas, na Escala de Auto- Estima Rosenberg-UNIFESP/EPM e SF-36. CONCLUSÃO: Houve impacto positivo na qualidade de vida, exceto da autoestima, de idosos que substituíram as próteses totais convencionais por overdentures mandibulares.
INTRODUCTION: The advent of endosseous dental implants has allowed the success of oral rehabilitation in order to obtain a better stability, retention, comfort, aesthetic, phonetic, functional capacity and well-being, with consequent longevity of oral health. The validated questionnaires about quality of life are proving to be increasingly indispensable and able to measure quantitatively the quality of life, as scientific content, through statistical data. OBJECTIVES: To evaluate the quality of life and self-esteem in elderly patients who have replaced conventional dentures for mandibular overdentures. METHODS: Twenty-seven patients (15 in study group and 12 in control group) were submitted to mandibular overdentures and were evaluated through questionnaires of quality of life in a self-administered attended: SF- 36, OHIP-49 and Rosenberg-UNIFESP/EPM Self-Esteem Scale. RESULTS: In the Wilcoxon test, a non-parametric test, statistical differences were observed, to the OHIP-49, in the study group to the following domains: functional limitation (p=0, 010), physical pain (p=0,020), physical disability (p=0,021), and psychological disability (p=0,040). In the Mann Whitney test, also a nonparametric test, statistical differences were observed, to the OHIP 49, second phase, to the following domains: functional limitation (p<0.001), physical pain (p=0,014), psychological discomfort (p=0,005), disability (p=0,022), psychological disability (p=0,007), social disability (p-0,031), disability (p=0,018), and total p (p=0,001). There were no statistical differences in the Rosenberg-UNIFESP/EPM Self-esteem Scale and SF-36. CONCLUSION: There was a positive impact on quality of life, except in relation to self-esteem, in elderly who have replaced conventional dentures for mandibular overdentures.
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BV UNIFESP: Teses e dissertações
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Rocha, Maria José Azevedo de Brito [UNIFESP]. "Body Shape Questionnaire, Escala de Auto-Estima Rosenberg/UNIFESP-EPM e Short-Form 36 após abdominoplastia." Universidade Federal de São Paulo (UNIFESP), 2007. http://repositorio.unifesp.br/handle/11600/39194.
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Previous issue date: 2007INTRODUÇÃO: A abdominoplastia visa a restaurar o contorno do abdome. O objetivo deste estudo é avaliar a imagem corporal, auto-estima e qualidade de vida em pacientes submetidas à abdominoplastia. MÉTODOS: Distribuiu-se 40 pacientes do gênero feminino, entre 25-60 anos de idade, IMC entre 19-30kg/m2, com deformidade abdominal tipos III e A pela classificação de NAHAS, em dois grupos: Grupo Estudo com 25 pacientes submetidas a abdominoplastia e Grupo Controle com 15 pacientes sem intervenção cirúrgica. Três questionários foram aplicados: BSQ, Escala de Auto Estima ROSENBERG/UNIFESP-EPM, SF-36 no pré e pós-operatório de um e seis meses no Grupo Estudo, no pré-operatório e após seis meses no Grupo Controle. RESULTADOS: Trinta e nove pacientes terminaram o estudo. No Grupo Estudo (24 pacientes), a abdominoplastia provocou impacto positivo no primeiro mês pósoperatório, mantendo-se no sexto mês. Houve diferença estatisticamente significante em valores totais e nas subescalas (BSQ), na auto-estima (ROSENBERG/ UNIFESPEPM) e no domínio saúde mental (SF-36). Nos domínios aspectos físicos, emocionais e vitalidade (SF-36), houve diferença estatisticamente significante apenas no pósoperatório de um mês. As demais dimensões não apresentaram diferença estatisticamente significante. No Grupo Controle, a diferença não foi estatisticamente significante em todos os domínios do BSQ, na auto-estima (ROSENBERG/UNIFESPEPM) e domínios do SF-36, com exceção do domínio vitalidade. Quando comparados os dois grupos aos seis meses, os valores não apresentaram diferença estatisticamente significante em nenhum dos domínios, com exceção da subescala percepção comparativa da imagem corporal (BSQ). CONCLUSÃO: A abdominoplastia promoveu melhora da imagem corporal, auto-estima e saúde mental.
INTRODUCTION: The purpose of abdominoplasty is to restore the contour of the abdomen. The aim of this study is to evaluate the body image, self-esteem and quality of life in patients who were undergone abdominoplasty. METHODS: Forty female, aged between 25 and 60, BMI between 19 and 30kg/m2, with abdominal deformities types III and A as classified by NAHAS were divided into two groups: Study Group with 25 patients who were undergone abdominoplasty, and Control Group with 15 patients, without surgical intervention. Three questionnaires were applied: the BSQ, Self-esteem Scale ROSENBERG/UNIFESP-EPM, and SF-36 during the pre and postoperative period from one to six months (Study Group); and in the preoperative and after six months (Control Group). RESULTS: The study was completed with 39 patients. In the Study Group (24 patients), abdominoplasty had a positive impact in the first post-operative month, and at the sixth postoperative month. There was statistically significant difference in the total values and in the subscales (BSQ), in the self-esteem (ROSENBERG/UNIFESP-EPM) and in the mental health aspect domains (SF-36). Physical, emotional roles and vitality domains (SF-36) showed statistically significant difference only in the first postoperative month. All other dimensions showed no statistically significant differences. The Control Group did not show statistical significance in all the BSQ, self-esteem (ROSENBERG/UNIFESP-EPM), and SF-36 domains, except in the vitality domain. There was no statistically significant difference in any of the domains, when both groups were compared after the period of six months, except for the comparative perception of the body image subscale (BSQ). CONCLUSION: Abdominoplasty improved body image, self-esteem and mental health.
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Leontescu, Mihai. "ePM: Project Management transposed online : The use of information communication tools to support inter-organizational project work." Thesis, Jönköping University, JIBS, Business Informatics, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-12460.
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The purpose of this bachelor paper is to analyze the different technologies used for supporting inter-organizational project work and how these technologies influence the project’s overall success. The results of this research have proved that the main impact ePM tools (e-Project Management tools) have upon inter-organizational projects are in terms of time-savings and easiness of communication when in need for communicating abroad with different business partners. Various types of collaboration tools can help the communication process between organizations and provide the project participants with the means of creating and supporting a collaborative environment. Other perceived benefits of ePM tools have been resulted including: reduce project costs due to time-savings and quality of information which lowers the risks for deficiency occurrences; improve the decision-making process; improve internal and external communication; facilitate knowledge sharing and expertise exchange; and create an agile business environment characterized by innovation, flexibility, faster market reaction and ability to work efficiently. Global time zones and communication skills are challenges to creating an efficient collaborative inter-organizational environment.
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Günther, Edeltraud, Wolfgang Uhr, Susann Kaulich, Lilly Scheibe, Claudia Heidsieck, and Jürgen Fröhlich. "Die Umweltleistungsmessung mit dem EPM-KOMPAS: ökologische Bewertung, ökonomische Maßnahmenbewertung und ökologische Erfolgsspaltung am Fallbeispiel eines KMU." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2004. http://nbn-resolving.de/urn:nbn:de:swb:14-1098446855125-60884.
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Die Ausarbeitungen zeigen, dass insbesondere im dritten Projektjahr des Forschungsprojektes EPM-KOMPAS auf das Ziel fokussiert werden konnte, gemeinsam mit sächsischen Industriepartnern ein Instrument zu entwickeln, das dem Ansatz des integrierten Managements von Umwelt- und Risikoaspekten folgt und als Einstiegshilfe in ein Umweltmanagement zur Steuerung der Umweltleistung, aber auch als Instrument zur systematischen Weiterentwicklung eines bestehenden Umweltmanagements zur Steuerung der Umweltleistung genutzt werden kann. Die entwickelte Software EPM-KOMPAS ist dabei für individuell wählbare Systemgrenzen (z. B. Prozess, Standort, Produkt etc.) einsetzbar und unterstützt die Unternehmen beim Handhaben von Gefahrstoffen und Abfällen, beim Anlegen von betrieblichen Stoff- und Energieströmen, beim Festlegen von Umweltzielen, beim Bewerten von Umweltmaßnahmen und beim Erstellen von Berichten für Behörden. Implementiert sind neben der klassischen Stoffstromanalyse auch ein "stiller Moderator", der durch die Software führt, die KOMPAS-Bewertung nach Günther/Kaulich für wesentliche Umweltaspekte und die ökologische Erfolgsspaltung. Durch den Aufbau des entscheidungsunterstützenden Instrumentes EPM-KOMPAS auf Basis einer Betrachtung von Kosten- und Stoffflüssen wird die Voraussetzung geschaffen, umfassende Ursachen- und Wirkungsanalysen durchzuführen. Darüber hinaus wird die Möglichkeit geboten, Auswirkungen von Entscheidungen bzw. Maßnahmen sehr genau zu analysieren und somit die Gefahr von Fehlentscheidungen zu reduzieren.
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Feng, Jiawei. "Compatibility and Shape Memory Effect Study of Maleated Ethylene Propylene Copolymer(MAn-g-EPM)/Fatty Acid Blends." University of Akron / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1500514544100023.
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Lourenço, Lana [UNIFESP]. "Short-form 36 e escala de auto-estima Rosemberg- EPM/UNIFESP em paraplégicos com úlcera por pressão." Universidade Federal de São Paulo (UNIFESP), 2010. http://repositorio.unifesp.br/handle/11600/10081.
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Previous issue date: 2010-04-28Introdução: A Lesão Medular Traumática está ent re as condições crônicas que causa incapacidades e consomem recursos na área de saúde. O indivíduo ao longo da vida produz signi ficantes perdas físicas, psicológicas e sócio-econômicas. A presença de úlcera por pressão (UP) é importante causa de alteração de qual idade de vida do paciente, agravando seu estado de saúde, aumentando o sofrimento e morbidade. Objetivo: Aval iar a qual idade de vida e a auto-est ima em paraplégicos com úlcera por pressão. Métodos: Estudo t ransversal , Cont rolado. A coleta de dados foi real izada por meio de inst rumento contendo dados demográficos e cl ínicos. A aval iação da qualidade de vida foi real izada pelo autor da pesquisa por meio do quest ionário genérico SF-36 e Escala de Auto-est ima Rosenberg – EPM/ UNIFESP. Part iciparam 120 paraplégicos por causas t raumát icas , 60 com úlcera por pressão no Grupo Estudo e 60 sem úlcera no Grupo Cont role. Para a anál ise foram ut il izados os Testes Qui-quadrado, Exato de Fisher e t de Student . Resultados: No Grupo Estudo, 93,3% eram do gênero mascul ino, média de 30,23 anos (DP=9,52) . Houve di ferença estat ística ent re os Grupos nos domínios do SF-36 Capacidade Funcional , Aspectos Fí sicos , Vi tal idade, Aspecto Emocionais com (p<0,0001), Aspectos Sociais (p<0,0013), Saúde Mental (p=0,0002), Dor (p=0,0002). Houve di ferença estat ística pelos resul tados obtidos na Escala de auto-est ima (p<0,001) ent re os grupos. Os valores de Al fa Cronbach do quest ionário SF-36 e da Escala de auto-est ima de Rosenberg EPM/UNIFESP foram a 0,79 e 0,74, respect ivamente. Conclusão: A presença de úlcera por pressão apresentaram impacto negat ivo na qual idade de vida e na auto-est ima de pacientes com LMT.
Background: Traumatic spinal cord injury is a chronic condition that cause disability and drain resources from the health sector. This condition will last for the patient’s lifetime, resulting in significant physical, psychological, social and economic consequences. Pressure ulcers are a major cause of reduction in quality of life, aggravating health conditions, and increasing suffering and morbidity. Objective: To evaluate health-related quality of life and self-esteem in paraplegic patients with pressure ulcers. Methods: This was a controlled crosssectional study. Sociodemographic and clinical data were obtained through a questionnaire. The evaluation of quality of life was performed by the first author of this paper using the generic Medical Outcomes Study 36-Item Short Form Health Survey questionnaire (SF-36) and the Rosenberg selfesteem/UNIFESP-EPM scale. A total of 120 patients with traumatic paraplegia were included in the sample, of which 60 had pressure ulcers and were assigned to the study group, and 60 had no pressure ulcers and were assigned to the control group. Statistical analysis was performed using the chi-square test, Fisher’s exact test, and Student’s t-test. Results: Of the 60 patients in the study group, 93.3% were men with a mean age of 30.23 years (standard deviation, 9.52 years). There were significant differences between groups in SF-36 scores on the physical functioning (p<0.0001), role physical (p<0.0001), vitality (p<0.0001), social functioning (p=0.0013), mental health (p=0.0002), bodily pain (p=0.0002), and role emotional (p<0.0001) subscales. There were also significant differences in self-esteem between groups (p<0.001). The Cronbach's alpha for the SF-36 questionnaire and Rosenberg selfesteem/UNIFESP-EPM scale was 0.79 and 0.74, respectively. Conclusion: Pressure ulcers had an adverse impact on the health-related quality of life and self-esteem of paraplegic patients
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BV UNIFESP: Teses e dissertações
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Kitzmann, Dione Iara Silveira. "Ambientalização sistêmica na gestão e na educação ambiental: estudo de caso com o ensino profissional marítimo – EPM." reponame:Repositório Institucional da FURG, 2009. http://repositorio.furg.br/handle/1/2819.
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Tese (doutorado)-Universidade Federal do Rio Grande, Programa de Pós-Graduação em Educação Ambiental, Instituto de Educação, 2009.Submitted by eloisa silva (eloisa1_silva@yahoo.com.br) on 2012-11-22T18:30:42Z No. of bitstreams: 1 dione iara silveira kitzmann.pdf: 2492483 bytes, checksum: 42375473cc494ce44406aa698a8593cd (MD5)
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Este trabalho tem por objetivo propor meios para integrar a Educação Ambiental (EA) à capacitação de trabalhadores portuários avulsos através da ambientalização curricular e sistêmica, seguindo referenciais e princípios da EA e da gestão ambiental. Para isto, foram considerados os níveis da macroescala (o sistema nacional de capacitação portuária), da mesoescala (o local da oferta) e da microescala (a sala de aula), com ênfase nesta última. A base teórica é multireferencial, com aportes das áreas da Educação e da Educação Ambiental, priorizando a discussão curricular, a ambientalização e a avaliação em Educação Ambiental. A metodologia emprega diferentes abordagens, utilizando como procedimentos e técnicas o estudo de caso (o Curso Básico do Trabalhador Portuário, aplicado em Rio Grande-RS); a aplicação de entrevista (com entrevistado de referência); a aplicação de questionários (a professores-instrutores) e a análise de documentos (registros de atividades em sala de aula com os trabalhadores portuários e documentos dos órgãos gestores do sistema). A estratégia escolhida constou de três fases: Fase I - o Diagnóstico do sistema e do triângulo interativo (professor, aluno, curso); Fase II - Estudo de Caso: o Curso Básico do Trabalhador Portuário – CBTP; Fase III: Elaboração das propostas. Os resultados indicam que, sob a ótica dos princípios da EA, o sistema de capacitação portuária tem pontos fracos (é pouco democrático e participativo; os cursos têm ênfase no saber-fazer, não são regionalizados; sua avaliação é classificatória; a EA é disciplinar, de baixa carga horária) e fortes (sistema em rede, bem organizado, com políticas contínuas e gestão estável, facilitando a implantação de mudanças; há uma cultura de sala de aula; há um espaço de avaliação permanente). A participação dos trabalhadores nas ofertas da disciplina “Meio Ambiente” trouxe importantes subsídios, dentre os quais as suas representações sobre meio ambiente, impactos ambientais cotidianos, e impactos ambientais portuários. O perfil dos professores-instrutores indica que este é semelhante ao nacional, tendo sido classificados como “instrutor portuário” e “instrutor técnico”, de acordo com as categorias de habilitação, experiência, conhecimento e formação. Os instrutores ouvidos são favoráveis à integração dos temas ambientais, mas indicam a falta de conhecimento e de capacitação ambiental como a principal limitação para tratá-los em suas disciplinas. A partir dos resultados obtidos, foi estruturada uma proposta metodológica de ambientalização curricular (a sequência: diagnóstico → critérios direcionadores → conceitos integradores → temas e conteúdos → ambientalização curricular) e três propostas de operacionalização: Estratégia de Ambientalização Curricular; Capacitação Ambiental do Docente Portuário; e Sistema de Indicadores Ambientais Portuários – SIAAP, que buscam integrar as mudanças curriculares à ambientalização institucional, a estratégias de capacitação ambiental de professores-instrutores e à definição dos indicadores de avaliação destas mudanças. Deste processo, concluímos que as oportunidades e forças identificadas permitirão que tais propostas sejam efetivadas no sistema de capacitação portuária, possibilitando uma ambientalização sistêmica, e abrangendo, além da microescala (os cursos), também a macroescala (o espaço portuário e ambiental adjacente).
This paper aims to propose ways of integrating Environmental Education (EE) with dockworkers training through the systemic curriculum environmentalization, following references and principles of both EE and environmental management. To do so, it was considered the levels of macroscale (the nacional system of ports capacitation), of mesoscale (the place of the offer) and of microscale (the classroom), emphasizing the last one. The theoretical base is multi-referential, with contributions from the fields of Education and Environmental Education, prioritizing curricular discussion, the environmental awareness and assessment in Environmental Education. The methodology employs different approaches, using procedures and techniques as the case study (the Standard Course of Port Workers, implemented in Rio Grande-RS), interview (with reference interviewee); questionnaires (teachers, instructors) and analysis of documents (records of activities in the classroom with the dockworkers and documents of the governing bodies of the system). The approach adopted consisted of three phases: Phase I - Diagnostic of the system and of the interactive triangle (teacher, student, course), Phase II - Case Study: The Standard Course of Port Workers - CBTP; Phase III: Preparation of proposals. The results indicates that, from the perspective of the principles of EE, the system of port capacity has weak points (it is poorly democratic or participative; the courses have emphasis in know-how only, are not regionalized; their evaluation is classificatory; the EE is a low-hours discipline) and strong ones (network system, well organized, with ongoing policy and stable management, facilitating the implementation of change; there is a classroom culture; there is an area of permanent evaluation). The dockworkers participations in the offerings of the course "Environment" have brought important benefits, as their representations of the environment, everyday environmental impacts, and ports‟ impacts on the environment. The teacherinstructors profile indicates that it is similar to the national level, being classified as “port instructor” and “technical instructor”, according to the categories of qualification, experience, knowledge and training. The instructors heard were favorable to the inclusion of environmental issues, but they indicate a lack of knowledge and environmental training as a major limitation to treat them in their disciplines. With the results obtained, it was structured a methodology proposal of curricular environmentalization (the sequence: diagnostic → criteria drivers → integrating concepts → themes and subjects → curricular environmentalization), and three proposals for implementation: Curricular Environmentalization Strategy, Environmental Training of the Port Instructor, and Environmental Ports Indicators System - SIAAP, seeking to incorporate curricular changes to the institutional environmentalization strategies for environmental training of teachersinstructors and also to the definition of indicators to evaluate these changes. Of this whole process is concluded that the opportunities and strengths identified will enable such proposals to be realized in the system capacity port, providing a systemic environmental awareness, which embrace not only the microscale (courses), but also the macroscale (the port area and surrounding environment).
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Duarte, Paulo de Camargo. "Evaluation of diagnostic tests and risk of exposure to the agents of equine protozoal myeloencephalitis (EPM) in California /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2003. http://uclibs.org/PID/11984.
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Brankovic, Milene Russo [UNIFESP]. "Short-Form 36, Escala de Autoestima Rosenberg-UNIFESP/EPM e Oral Health Impact Profile em pacientes submetidos ao clareamento dental." Universidade Federal de São Paulo (UNIFESP), 2010. http://repositorio.unifesp.br/handle/11600/10082.
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Previous issue date: 2010-11-24INTRODUÇÃO: Os avanços tecnológicos do clareamento dental têm possibilitado o sucesso no tratamento odontológico, na obtenção de maior efetividade nos benefícios indiretos como a consciência com a higiene, mudanças de hábitos e a preservação da capacidade funcional e do bemestar, com consequente longevidade da saúde bucal. Os instrumentos de qualidade de vida quantificam objetivamente estas mudanças e são capazes de demonstrar o impacto positivo na saúde e na autoestima destes pacientes. OBJETIVO: Avaliar a qualidade de vida e autoestima em pacientes submetidos ao clareamento dental. MÉTODOS: Este estudo foi composto por 45 pacientes (30 grupo estudo e 15 grupo controle) submetidos ao clareamento dental e à aplicação de questionários autoaplicáveis para avaliação de qualidade de vida, autoestima, e saúde bucal (SF-36, Escala de Auto-Estima Rosenberg-UNIFESP/EMP e OHIP-49). RESULTADOS: Nos testes não paramétricos de Wilcoxon foram observadas diferenças de significância estatística no domínio de autoestima do grupo estudo (p=0,002); bem como no SF-36 no domínio vitalidade (p=0,019). No OHIP-49 houve diferença significante no domínio limitação funcional (p=0,015); dor física (p=0,014); desconforto psicológico (p=0,003) e incapacidade psicológica (p-0,016). Nos testes não paramétricos de Mann-Whitney, na análise intergrupos observouse diferença de significância estatística na autoestima (p=0,011), no OHIP- 49 nos domínios desconforto psicológico (p=0,045), incapacidade psicológica (p=0,017) e total (p=0,040). O SF-36 não apresentou diferença significativa em nenhum domínio. CONCLUSÃO: O clareamento dental promoveu impacto positivo na qualidade de vida e autoestima dos pacientes.
INTRODUCTION: Technological advances in dental bleaching have allowed success in dental treatment, with greater effectiveness in indirect benefits such as awareness of oral hygiene, changes in habits and preservation of functional capacity as also well-being and longevity with consequent oral health, which considers the quality of life and self-esteem. OBJECTIVE: To evaluate the quality of life and self-esteem in patients undergoing tooth whitening. METHODS: Forty-five patients (30 patients in study group and 15 in control group) were submitted to dental bleaching and to self-applied questionnaires to assess self-esteem, quality of life and oral health (Rosenberg, SF-36 and OHIP-49). RESULTS: Through the nonparametric Wilcoxon test statistically significant differences were observed in self-esteem of study group (p=0,002), as well as the SF-36 vitality domain (p=0,019). In the OHIP- there was no significant difference in functional limitation domain (p-0.015); physical pain (p-0,014); psychological distress (p=0,003) and psychological disability (p=0,016). In the nonparametric Mann-Whitney test, intergroup analysis showed difference of statistical significance in self-esteem (p=0,011), as also in the OHIP-49 in psychological discomfort (p=0,045), psychological disability (p=0,017) and total domains (p=0,040). The SF3-6 showed no significant difference in any questionnaire. CONCLUSION: Tooth whitening presented a positive impact on selfesteem and quality of life of patients.
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BV UNIFESP: Teses e dissertações
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Swerts, Ana Cláudia [UNIFESP]. "Health Assessment Questionnaire e escala de auto-estima Rosemberg/UNIFESP-EPM em pacientes submetidos a mastectomia por câncer de mama." Universidade Federal de São Paulo (UNIFESP), 2006. http://repositorio.unifesp.br/handle/11600/21442.
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Zapatera, Llinares Alberto. "La competencia “mirar con sentido” de estudiantes para maestro (EPM) analizando el proceso de generalización en alumnos de Educación Primaria." Doctoral thesis, Universidad de Alicante, 2015. http://hdl.handle.net/10045/52046.
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Esta tesis se encuentra en la intersección de dos líneas de investigación: por un lado, la que trata de caracterizar la competencia docente mirar profesionalmente el pensamiento matemático de los estudiantes y, por otro lado, la que se centra en el desarrollo del pensamiento algebraico temprano usando problemas de identificación de patrones. El objetivo de esta investigación es caracterizar perfiles de la competencia docente mirar profesionalmente el pensamiento matemático de los estudiantes en el contexto específico de la generalización de patrones.
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Slabbert, Francois Naudé. "The effect of acute and chronic sildenafil treatment with and without atropine co-administration on anxiety-like behaviour in rats / Francois Naudé Slabbert." Thesis, North-West University, 2010. http://hdl.handle.net/10394/8424.
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The neurobiology of anxiety-related disorders is associated with impaired neuroplasticity. The glutamate/NO/cGMP pathway has been proposed to play a key role in neuroplasticity and neurodevelopment. It was demonstrated in recent reports that chronic co-administration of the phosphodiesterase type 5 (PDE5) inhibitor sildenafil and the antimuscarinic agent atropine exerts antidepressive-like activity in rats, and that this effect is related to PDE5 inhibition, with consequent elevation of cGMP levels and enhanced protein kinase G stimulation.
The current study investigated possible anxiolytic effects of the chronic co-administration of sildenafil and atropine in stress-sensitive Flinders Sensitive Line (FSL) rats. FSL rats received vehicle control, fluoxetine (15 mg/kg), atropine (1 mg/kg), sildenafil (10 mg/kg) or sildenafil plus atropine via intraperitoneal administration, either acutely 30 minutes prior to testing (acutely) or daily for 14 days (chronically). FRL control rats received only vehicle. Thereafter anxiety-like behaviour was evaluated in the social interaction test (SIT - acute) and elevated plus maze (EPM - acute and chronic). The current study also compared to different ways to score the EPM, namely the percentage time spend in the open arms of the EPM and both the number of full and half body open arm entries, and also implemented defecation on the EPM as a measure of anxiety.
Vehicle-treated FSL rats exhibited more anxiety-like behaviour than FRL rats in both the SIT and EPM following acute treatment, and in the EPM following chronic treatment. Acute treatment with fluoxetine exerted anxiogenic activity in the SIT and EPM, but anxiolytic activity following chronic administration, as observed in the EPM. In acute treatments neither sildenafil nor sildenafil plus atropine yielded any significant effects on anxiety-like behaviour. However, following chronic treatment, sildenafil exerted anxiolytic activity in the EPM by increasing the time spend in the open arms (45.72% ± 9.94% vs. 20.80% ± 9.94%, P<0.001). Atropine exerted a small anxiolytic response (30.71% ± 8.40% vs. 20.80 ± 9.94%), whereas atropine co-administration was additive to sildenafil alone and yielded an enhanced anxiolytic effect in the elevated plus maze (59.56% ± 4.95% vs. 20.80% ± 9.94%, P<0.001), relative to vehicle control. The percentage time spend in the open arms was scored in the EPM, the results suggested that the chronic treatment with sildenafil plus atropine exert an anxiolytic-like effect in FSL rats and the number of fecal droppings did not increase which is also an indication of an anxiolytic-like effects of the treatment.
The current study demonstrated that the chronic treatment with sildenafil, alone or in combination with atropine, exhibit an anxiolytic-like action in stress-sensitive rats. In addition, the data support the clinical potential of using PDE5 inhibitors as antidepressant and anxiolytic strategy and warrant further investigation. Furthermore the study supports the previously proposed key role of the glutamate/NO/cGMP pathway in the neurobiology of anxiety-like disorders, and as an important target for drug development.Thesis (M.Sc. (Pharmacology))--North-West University, Potchefstroom Campus, 2011
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Jägerup, Beatrice. "The Origin of the Gran Canarian Xenoliths." Thesis, Uppsala universitet, Institutionen för geovetenskaper, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-311753.
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Xenoliths are pieces from the surrounding bedrock, brought to the surface of the earth by host magma. On Gran Canaria, the largest island in the Canary Islands archipelago, strange xenoliths have been found. They are light in color, porous and very different from the basaltic magma carrying them. By studying petrological features and oxygen isotope content of the xenoliths, the focus of this report will be to investigate their origin. The minerals and texture of 14 samples were studied in thin section, and the δ18O–value was determined for 17 samples. The mineralogical composition of xenolith glass was examined by EPMa. The results show that the xenoliths are rich in silica rich glass, quartz and feldspars, but also have high calcium content. 9 of 14 xenoliths have textures and δ18O–values from 8.1 ‰ to 16.77 ‰, similar to sedimentary rocks. The remaining xenoliths are metamorphosed and exhibit altered phenocrysts, indicating they have been melted and recrystallized. The latter group also has extremely low δ18O–value, which could be explained by the effects of hydrothermal processes. Most likely all the xenoliths originate from the prevolcanic sedimentary deposits beneath Gran Canaria.
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Carvalho, Maria Inês Bustamante de [UNIFESP]. "Escala de auto-estima Rosemberg/UNIFESP-EPM em funcionários da Fundação de Ensino Superior do Vale do Sapucaí em Pouso Alegre." Universidade Federal de São Paulo (UNIFESP), 2006. http://repositorio.unifesp.br/handle/11600/21412.
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Previous issue date: 2006Introdução: A percepção da qualidade de vida é individual e diretamente associada ao contexto sócio-cultural onde o indivíduo está inserido. O auto-conceito e a auto-estima, bases da representação que o indivíduo tem de si, envolvem o bem estar individual e social. O conceito de auto-estima tem sido estudado e considerado um importante indicador de saúde mental. Objetivo: O objetivo deste estudo é avaliar a auto-estima de funcionários da Fundação de Ensino Superior do Vale do Sapucaí em Pouso Alegre MG. Métodos: Estudo analítico transversal com 582 funcionários, homens e mulheres, maiores de 18 anos, sorteados por tabela de números aleatórios gerada pelo programa Epitable. Foi respondido um protocolo de dados demográficos e em seguida, a escala de auto-estima de Rosenberg UNIFESP-EPM foi aplicada para avaliar a auto-estima. Os testes de Mann Whitney e o teste Kruskal-Wallis foram utilizados na análise estatística. Resultados: Dos 582 sujeitos estudados, o maior escore de auto-estima foi 21, sendo que 98 sujeitos (16,8 por cento) obtiveram escore zero e 90 por cento da população estudada teve escores menores que 10. A média de escores do Rosenberg foi de 5,07 , com um intervalo de confiança (95 por cento) = 4,72 - 5,42; a mediana ficou em 4,0. Foi encontrada significância estatística relacionando auto-estima e gênero (p = 0,0113) o maior escore para homens foi de 13 e para mulheres foi 21. Conclusão: O nível de auto-estima encontrado na população estudada foi alto (90 por cento dos escores menores que 10), e a auto-estima dos homens foi significantemente mais elevada que das mulheres (p =0,0123).
BV UNIFESP: Teses e dissertações
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Morison, Rebecca, and n/a. "The impact of electronic performance monitoring on staff turnover in a call centre environment." University of Canberra. Health Sciences, 2002. http://erl.canberra.edu.au./public/adt-AUC20050530.111117.
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Call Centres represent one of the fastest growing industries today. In a competitive
business environment the service delivered by Call Centre operators needs to be quantified
and this is achieved through Electronic Performance Monitoring (EPM). This study
considered the effects of EPM, and related factors such as job control, task complexity,
performance, goal-setting and feedback, on the job satisfaction, organisational commitment
and work stress, of Call Centre operators. The impact of these factors on staff turnover,
which media reports suggest is very high for many Call Centres, was also considered. A
total of 388 participants (265 females, 123 males) completed a voluntary self-report
questionnaire. All participants were Call Centre operators who were working in one of 27
call centres across Australia in a variety of industries, including Banking & Finance, IT,
Employment, Insurance and Telecommunications. All operators were working in an
electronically monitored environment. Regression and path analyses revealed age, that is
younger employees, and job dissatisfaction to be the only variables that predicted staff
turnover. A positive perception of EPM was predicted by a positive perception of both
goal-setting and feedback. It was concluded that while staff turnover was high in the
current sample, it was not associated with perceptions of EPM, and other factors appeared
to be more important.
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Walsh, Catherine Patricia. "Pathogenic and antigenic characterization of Neospora hughesi." Thesis, Virginia Tech, 2000. http://hdl.handle.net/10919/32893.
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Neospora hughesi is a recently described cause of equine protozoal myeloencephalitis (EPM). In the present study, we examined the susceptibility of BALB/c gamma-interferon gene knockout (gamma-INFKO), BALB/c, CD-1, and C57BL/6 strains of mice and gerbils to infection with tachyzoites of the Nh-A1 strain of N. hughesi. Only the gamma-IFNKO mice developed severe clinical disease following infection with N. hughesi. The most severe lesions were in the hearts of these mice. Two dogs fed the brains of mice, shown to contain N. hughesi tissue stages by cell culture and g-IFNKO mouse bioassay, did not shed N. hughesi oocysts over a 23 day observation period.
We report important differences between the nucleotide and deduced amino acid sequences of the dense granule proteins GRA6 and GRA7 of N. hughesi and N. caninum. The newly defined proteins of N. hughesi are referred to as NhGRA6 and NhGRA7. From analysis of the sequences we found that there is a 14.8% difference in deduced amino acid sequence between NhGRA7 and NcGRA7, and a 4% difference between NhGRA6 and NcGRA6 in areas that could be compared.
This thesis supports the identification of N. hughesi as a separate species from N. caninum and describes novel methods of distinguishing between the two.
Master of Science
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Högman, Cecilia. "Explorative strategies in the open field (OF), elevated plus maze (EPM) and multivariate concentric square fieldTM (MCSF) in adolescent male Wistar rats." Thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-220274.
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Mental disorders, like anxiety and depression, are a major health problem and can appear early in life. Developing new compounds for anxiety and other mental disorders is desirable and requires good animal models. Two widely used tests to evaluate fear and anxious behavior in rodents are the open field (OF) and elevated plus maze (EPM) tests. The models are simple and it has been argued that different environments give different behavior profiles and measure different kind of behavior. The multivariate concentric square fieldTM (MCSF) is a new test that gives the rodent opportunity to visit different environments and to evaluate more parameters in one test. Validation of the tests is mainly done with adult animals. The aim with this study is to study adolescent rat behavior in the OF, OF with start box, EPM and MCSF tests and to see if there is any difference in running trials in the morning or in the afternoon. A total of 48 adolescent male Wistar rats were divided into 12 rats per group. The groups were OF and MCSF, OF with start box and MCSF, EPM and MCSF, and repeated testing in MCSF. Each session was 20 minutes and there was one week between the two tests. Three rats where run in the morning and three in the afternoon. Statistical analysis did show significant difference in some parameters in the comparison between running trials in the morning or in the afternoon. Repeated testing in the MCSF yielded differences in trial two compared to trial one. No significant difference was found in the trend analysis. The results show individual differences and with larger groups results may have been more liable. In this study some differences were found between morning and afternoon groups. Lots of data have been generated and there are many opportunities to use the same data for additional analyses.
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Lewis, Stephanie Rochelle. "Experimental infection with Sarcocystis neurona alters the immune response: the effect on CD4+, CD8+, B-cell, monocyte and granulocyte populations in horses." Thesis, Virginia Tech, 2009. http://hdl.handle.net/10919/33919.
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Previous studies have demonstrated differences in CD4+, CD8+ and B-cell populations between EPM affected and normal horses. The overall goal of our project was to further define the immune deficiencies associated with S. neurona infection. We hypothesized that PMA/I stimulated suppression in EPM horses is due to decreased proliferation of monocytes, CD4+ and CD8+ cells. Our objectives were 1) to determine whether S. neurona infection causes an increase in apoptosis of a particular immune subset, and 2) to determine whether S. neurona causes a decrease in the number of cellular divisions (proliferation) of a particular immune cell subset.
For this study, nine S. neurona antibody negative, immunocompetent horses were obtained. Baseline neurologic examinations, SnSAG1 (S. neurona Surface Antigen 1) ELISAs on cerebrospinal fluid (CSF) and serum, and baseline immune function assays were performed. Horses were randomly divided into groups. Five horses were challenged for ten days via intravenous injection of autologous lymphocytes infected with S. neurona. Neurologic parameters of all horses were assessed for 70 days following infection. Immune function was based on proliferation responses to mitogens, as assessed through thymidine incorporation. Enumeration of cellular subsets, degree of apoptosis and number of cellular divisions were assessed through flow cytometry. SnSAG1 ELISA of serum and CSF samples performed post-infection confirmed infection and disease. All infected horses displayed moderate neurologic signs on clinical examination. Some significant differences in cellular activities were noted. Additionally, this is the first time the method using S. neurona infected lymphocytes has been reproduced successfully by different investigators.
Master of Science
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Lidström, Cristian, and Caroline Druzynski. "Big Brother – Buddy or Bully? : How the combined use of an organizations’ goal setting and Electronic Performance Monitoring (EPM) affects the employees’ work attitudes." Thesis, Uppsala University, Department of Business Studies, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-127100.
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Salomé, Geraldo Magela [UNIFESP]. "Short form-36, Escala de autoestima Rosenberg/UNIFESP–EPM, Health Assessment Questionnaire-20 e dor em pacientes após enxerto de pele em úlcera venosa." Universidade Federal de São Paulo (UNIFESP), 2011. http://repositorio.unifesp.br/handle/11600/10079.
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Previous issue date: 2011-04-27Introdução: A úlcera de perna causa sofrimento aos pacientes, afetando seu quotidiano devido a(o): dor, isolamento social, autoimagem e autoestima prejudicadas. Objetivo: Avaliar a qualidade de vida, autoestima, capacidade funcional e dor em pacientes com úlcera venosa pósenxerto de pele. Métodos: Estudo multicêntrico, comparativo e controlado, realizado nos ambulatórios: de Cirurgia Plástica do Hospital São Paulo e de Feridas do Conjunto Hospitalar de Sorocaba. Casuística: 50 pacientes - Grupo Controle; 50 - Grupo Estudo. Aprovado pelo Comitê de Ética em Pesquisa da Universidade Federal de São Paulo. Coleta de dados: julho- 2008 a dezembro-2010. Grupo Controle: coleta de dados no momento da inclusão no estudo, aos 30, 90 e 180 dias subsequentes. Grupo Estudo: primeira coleta no pré-operatório - 30, 90 e 180 dias após o enxerto. Instrumentos: Short Form-36, Escala de autoestima Rosenberg/UNIFESP–EPM, Health Assessment Questinnaire-20 (HAQ-20), Escala Numérica de dor, questionário de Dor de Mc Gill. Análises estatísticas: Teste t Student, o TesteKruskal- Wallis, Teste Qui-Quadrado de Independência, considerando-se os níveis de significância p ≤ 0,05. Resultados: avaliação inicial do paciente com úlcera venosa: escores do SF-36 baixos: média 18,10 - Grupo Controle e 32,34 - Grupo Estudo. Um mês após enxerto, pacientes Grupo Estudo apresentaram escores mais elevados no SF-36 (71,38) comparados ao GC (18,42). Após 90 e 180 dias, aumento dos escores no GE comparados ao Grupo Controle(p=0,0001). Escore médio no HAQ-20: 2,42 - Grupo Controle e 2,65 - Grupo Estudo. Grupo Estudo: melhora nos escores após 90 dias e 180 dias do enxerto (p=0,0001). Pela Escala de Autoestima Rosenberg/UNIFESP–EPM, na inclusão dos pacientes no estudo, escore médio no Grupo Controle: 25,50, Grupo Estudo: 25,86. Após 90 dias e 180 dias, Grupo Estudo: melhor escore comparado ao Grupo Controle (p=0,0001). Pela Escala Numérica e pelo Questionário de Dor de Mc Gill, os dois grupos apresentaram dor durante a primeira coleta de dados. Grupo Estudo: após 90 dias e 180 dias de pós-operatório, houve declínio da dor (p=0,0001). Conclusão: Pacientes com úlcera venosa após enxerto de pele melhoraram qualidade de vida, autoestima, capacidade funcional e dor.
Objective: To assess quality of life, self-esteem, functional capacity and pain in patients with venous ulcer after skin graft. Methods: Clinical, multicenter, analytical, prospective, comparative, controlled and non-randomized study. This study was carried out in the plastic surgery outpatient clinic of Hospital São Paulo and in the Wound Outpatient clinic at Conjunto Hospitalar de Sorocaba. The case series was formed by 50 patients in the Control Group (CG) and 50 patients in the Study Group (SG) both with diagnosis of venous ulcer and indication for skin graft. The study was approved by the Research Ethics Committee at the Universidade Federal de São Paulo, under authorization #: 0945/08. Data collection was carried out from July 2008 and December 2010. In the CG, data collection was carried out at the time patients were included in the study, and then 30, 90 and 180 days after the first collection. In the SG, the first collection was carried out in the preoperative period and then 30, 90 and 180 days after skin graft. All patients of the CG were operated on after 180 days. Inclusion criteria were: being over 18 years old and having a diagnosis of venous ulcer with referral for skin coverage with skin graft. Exclusion criteria were: Skin lesions that were not completely characterized as venous ulcer, patients with clinical conditions that contraindicated surgery, and patients that had already undergone skin graft. The instruments used for data collection were: Short Form- 36, the Rosenberg self-esteem scale/UNIFESP–EPM, the Health Assessment Questionnaire-20 (HAQ-20), the Numeric Pain Scale, and the Mc Gill pain questionnaire. For statistical analysis, we have used Students’ t test, Kruskal-Wallis test and the Chi-square test of independence. It was fixed in 0.05 or 5% (p ≤ 0.05). Outcomes: In the initial assessment of patients with venous ulcer, the SF-36 scores were low, with a mean score of 18.10 in the CG, and 32.34 in the SG. One month after skin graft was carried out, patients in the SG presented higher scores in the SF-36 (71.38) compared to the CG (18.42). After 90 and 180 days there was also an increase in the scores of the SG compared to the CG (p=0.0001). Mean scores in the HAQ-20 was 2.42 in the CG and 2.65 in the SG, and in the SG there was an improvement in the scores 90 and 180 days after skin graft was carried out (p=0.0001).As for the Rosenberg self-esteem scale/UNIFESP–EPM, in the inclusion of patients in the study, the mean score was 25.50 in the CG, and 25.86 in the SG, and after 90 days and 180 days the SG presented better score compared to the CG (p=0.0001). As for pain assessment using the Numeric Scale and the McGill pain questionnaire, both groups of patients presented pain during the first data collection, however, in the SG 90 and 180 days after surgery, patients presented less pain (p=0.0001). Conclusion: Patients with venous ulcers, that underwent skin graft presented improvement in the quality of life, self-esteem, functional capacity and less pain.
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BV UNIFESP: Teses e dissertações
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Ferrarini, Stefano. "Studio del comportamento di poli-alfa-olefine come modificatori di viscosità negli oli lubrificanti." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/11868/.
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Il buon funzionamento di una qualsiasi tipologia di motore prevede l’utilizzo di un componente che abbia il compito di lubrificare le parti meccaniche in movimento, come, ad esempio, l’olio motore per l’automobile. Un fattore determinante nella scelta dell’olio è la variazione della sua viscosità in relazione alla variazione di temperatura, poiché la temperatura di esercizio di un macchinario è solitamente diversa dalla temperatura di avviamento. Tale valore viene identificato in maniera assoluta dal Viscosity Index (VI). L’olio motore è una formulazione complessa in cui sono presenti l’olio base ed una serie di additivi, tra cui molto importante è il modificatore di viscosità (Viscosity Index Improver, VII), che migliora il VI e permette di utilizzare lo stesso olio a basse ed alte temperature (olio multigrade). Come VII possono essere utilizzate diverse tipologie di polimeri solubili in olio, che variano per caratteristiche e target di mercato. La famiglia presa in esame in questa tesi è quella delle poli-alfa-olefine, utilizzate prevalentemente con oli base minerali, e più precisamente copolimeri etilene/propilene. Sono state analizzate le proprietà che questa famiglia ben nota di OCP (Olefin CoPolymer) ingenera nel sistema base-polimero. In particolare si è cercato di correlare le proprietà molecolari del polimero (composizione, peso molecolare e paracristallinità) con le proprietà “tecnologico-applicative” di ispessimento, stabilità meccanica al taglio, punto di non scorrimento, avviamento a freddo, pompabilità a freddo. L’attività è proseguita con la progettazione di un modello fisico, con l’obiettivo di predire il comportamento tecnologico del sistema olio-polimero in funzione delle proprietà molecolari di polimeri appartenenti alla classe delle poli-alfa-olefine lineari, esaminando anche le proprietà tecnologiche di un omopolimero sperimentale.
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Yang, Jibing. "Investigation of Immune Response to Sarcocystis neurona Infection in Horses with Equine Protozoal Myeloencephalitis." Thesis, Virginia Tech, 2005. http://hdl.handle.net/10919/34205.
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Equine Protozoal Myeloencephalitis (EPM) is a serious neurologic disease of horses in the United States. The primary etiologic agent is Sarcocystis neurona (S. neurona). Currently, there is limited knowledge regarding the protective or pathologic immune response to infection to the intracellular protozoa S. neurona. The objective of these studies was to determine the effects of S. neurona infection on the immune response of horses that had EPM due to natural infection (experiment 1) and experimental infection (experiment 2). In experiment 1, twenty-two horses with naturally occurring cases of EPM, which were confirmed positive based on detection of antibodies in the serum and/or CSF and clinical signs, and 20 clinically normal horses were included to determine whether S. neurona altered the immune responses, as measured by immune cell subsets (CD4, CD8, B-cell, monocytes, and neutrophils) and leukocyte proliferation (antigen specific and non-specific mitogens). Our results demonstrated that naturally infected horses had significantly higher percentages of CD4 and neutrophils (PMN) in peripheral blood mononuclear cells (PBMCs) than clinically normal horses. Leukocytes from naturally infected EPM horses had a significantly lower proliferation response, as measured by thymidine incorporation, to a non-antigen specific mitogen phorbol 12-myristate 13-acetate (PMA) / ionomycin (I) than did clinically normal horses (p=0.04). The implications of these findings will be discussed.
In experiment 2, 13 horses were randomly divided into two groups. Baseline neurologic examinations were performed and all horses were confirmed negative for S. neurona antibodies in the CSF and serum. Then, one group with 8 clinically normal seronegative horses was inoculated intravenously with approximately 6000 S. neurona infected autologous leukocytes daily for 14 days. All the challenged horses showed neurologic signs consistent with EPM. PBMCs were isolated from the control and infected horses to determine how S. neurona alters the immune responses based on changes in immune cell subsets and immune function. There were no significant differences in the percentage of CD4 cells in peripheral blood lymphocytes or IFN-γ production by CD4 and/or CD8 cells. PMA/I stimulated proliferation responses in PBMCs appeared suppressed compared to that of uninfected controls. Additional studies are necessary to determine the role of CD4 and CD8 cells in disease and protection to S. neurona in horses, as well as to determine the mechanism associated with suppressed in vitro proliferation responses. This project was funded by Patricia Stuart Equine grants and paramutual racing funds from Virginia Tech.
Master of Science
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Gustavsson, Robert, and Marcus Söderlund. "The Impact of Remote Work on Performance Monitoring." Thesis, Uppsala universitet, Företagsekonomiska institutionen, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-447695.
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This study aims to examine how the shift from analog to remote work, as a result of digitalization, has affected performance monitoring in organizations and impacted management control systems. Earlier studies within the subject show that a shift results in a reduction in performance monitoring or that classical performance monitoring are replaced with electronic performance monitoring (EPM). In order to examine how performance monitoring changes as a result of the shift and if management control has gotten tighter or looser, this thesis has been based on four semi-structured interviews that were held with managers from three different Swedish organizations. The shift to remote work shows tendencies of a loosening of control in the organizations and to compensate for the loss, managers have implemented different Electronic Performance Monitoring (EPM) systems. The most common EPM systems implemented were video meetings, but other EPM systems were also implemented such as online monitoring. But managers still experience an overall loosening of control as a result of the shift to remote work. Trust seems to be a factor that becomes more important as a result of the shift and seems to have a mitigating effect on the degree of EPM systems the managers choose to implement.
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Cipriano, Ana Cláudia. "Avaliação neuropsicofarmacológica dos mecanismos CRFérgicos na amídala, nas reações de defesa de camundongos pré-expostos à derrota social." Universidade Federal de São Carlos, 2015. https://repositorio.ufscar.br/handle/ufscar/7177.
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Stressful situations are a real or potential threat for psychological or physiological integrity of an individual. The underlying neurobiological substrates involved in these processes were substancially investigated through the use of animal models of stress. In this context, a crescent number of studies have used more naturalistic animal tests, such as the social defeat test. Regarding neurobiological substrates, it is known that the amygdala plays an important role in the modulation of defensive responses. This forebrain structure has several neurotransmitters and receptors with important implications in emotional states. In this context, the neuropeptide Corticotropin Releasing Factor (CRF) and its receptors, CRF1 and CRF2, have been recently investigated as an important modulatory system of defensive reactions to aversive situations. Activation CRF mechanisms in the amygdala has been postulated as a possible neurochemical substrate underlying the emotional disorders, especially anxiety disorders, induced by stress in humans. To study anxiety-related responses induced by stressors in animals, the elevated plus maze (EPM) test has been widely used. While previous studies have emphasized the role of CRF1 receptors in modulation of anxiety in rodents exposed to the EPM, the involvement of CRF2 receptors remains unclear. Few studies, however, have investigated the effects of CRF and CRF1 and CRF2 antagonists injected directly into the amygdala on the defensive responses in mice. In addition, several studies are needed to clarify the complex relationship between CRF neurotransmission of the amygdala in the etiology of anxiety disorders related to previous exposure to stress. This study investigated the role of CRF in the amygdala upon the defense reactions evaluated in the EPM in mice previously exposed to acute social defeat. Therefore, we carried out experiments to (i) characterize the effects of acute social defeat on behavior in the EPM and on the levels of plasma corticosterone; (ii) to investigate the effects of intraamygdala microinjection of CRF, CRF1 and CRF2 antagonists on the behavior of mice in the EPM and (iii) to investigate the effects of intra-amygdala microinjections of CRF1 and CRF2 antagonists on anxiety-related behaviors of mice pre-exposed to acute social defeat. Results showed that the exposure to acute social defeat stress produces anxiogenesis at short and long terms (i.e, assessed 5 min and 10 days after stress exposure), however short-term anxiety response is variable. Stress-short term effects are accompanied by increased plasma corticosterone levels. In addition, while intra-amygdala CRF increases anxiety, local injection of CRF1 (but not CRF2) receptor antagonists produced anxiolytic-like effects, suggesting a tonic role of CRF1 in the modulation of anxiety in mice exposed to the EPM. However, it was not possible to determine what is the role of CRF neurotransmission in the responses displayed by mice pre-exposed to social defeat and submitted to EPM.
O estresse é uma ameaça real ou potencial para a integridade psicológica ou fisiológica de um indivíduo e que resulta em respostas fisiológicas e/ou comportamentais. Os conhecimentos sobre estas respostas bem como sobre os substratos neurobiológicos envolvidos nestes processos só foram possíveis com o desenvolvimento de modelos animais de estresse. Dentre os vários modelos utilizados, destaca-se o modelo de derrota social por suas características mais etológicas. Em relação aos substratos neurobiológicos, é sabido que a amídala tem um importante papel na modulação de respostas defensivas. Esta estrutura encefálica possui diversos neurotransmissores e respectivos receptores com importantes implicações em estados emocionais, dentre eles o Fator de Liberação de Corticotropina (CRF). Os mecanismos de ação do CRF se dão por sua interação com os receptores CRF1 e CRF2. A ativação destes receptores na amídala tem sido postulada como um dos possíveis substratos neuroquímicos das alterações queocorrem nos transtornos comportamentais induzidos por estresse em humanos, destacando-se os transtornos de ansiedade por serem os mais prevalentes na população. Como ferramenta de estudo desses transtornos, temos o labirinto em cruz elevado (LCE), um dos mais populares modelos animais de ansiedade. Estudos no LCE apontam que o CRF1 modula a ansiedade, enquanto o papel do CRF2 não está claro. Poucos estudos, no entanto, têm investigado os efeitos do CRF, bem como de antagonistas para CRF1 e CRF2 injetados diretamente na amídala sobre as respostas defensivas de camundongos. Além disso, ainda se fazem necessários diversos estudos para entender a complexa relação entre a neurotransmissão CRFérgica da amídala na etiologia de transtornos de ansiedade relacionados a prévia exposição ao estresse. Sendo assim, o objetivo deste estudo é investigar o papel do CRF na amídala, nas reações de defesa avaliadas no LCE em camundongos previamente expostos ao estresse de derrota social agudo. Para tanto, realizou-se experimentos para (i) caracterizar os efeitos do estresse de derrota social agudo sobre o comportamento de camundongos no LCE e sobre os níveis de corticosterona plasmática; (ii) investigar os efeitos de microinjeções intra-amídala de CRF e de antagonistas CRF1 e CRF2 sobre os comportamentos de camundongos no LCE e (iii) investigar os efeitos de microinjeções intra-amídala de antagonistas CRF1 e CRF2 em camundongos pré-expostos ao estresse de derrota social agudo e submetidos ao LCE. Os resultados obtidos demonstram que o estresse de derrota social agudo é ansiogênico a curto e longo prazos, entretanto a resposta de ansiedade a curto prazo é variável. Estes mesmos efeitos a curto prazo são acompanhados por aumento do nível de corticosterona plasmática. Ainda demonstram que o CRF na amídala é ansiogênico e que há uma modulação tônica via CRF1, já o papel do CRF2 continua indeterminado. Entretanto, não foi possível determinar o papel da neurotransmissão CRFérgica nas respostas exibidas por camundongos pré-expostos ao estresse de derrota social e submetidos ao LCE.
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Thomaz, Tatiana dos Santos. "Refuncionalização espaciais das estruturas de saúde na cidade de São Paulo: a implementação do paradigma tecnológico da medicina no Hospital das Clínicas (FMUSP) e no Hospital São Paulo (EPM-Unifesp)." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/8/8136/tde-17042017-104456/.
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Na incessante transformação da cidade, incorporaram-se novos objetos e sistemas técnicos que refletem a lógica hegemônica contemporânea e, com isso, os velhos objetos e sistemas técnicos foram submetidos a refuncionalizações com o objetivo de se adequar a essa nova lógica do sistema produtivo. E a medicina não escapa a essa lógica, já que foi com o desenvolvimento da técnica atrelada ao conhecimento científico que o paciente passou a ser visto de forma cada vez mais artificializada, abrindo-se novas possibilidades de intervenção no doente. Logo, os hospitais passaram a se situar no centro do exercício dessa medicina, convertendo-se em atividade econômica, lugar de consumo de serviços de saúde, inseridos na lógica urbana, promovendo constantes mudanças nos padrões tecnológicos que levam a grandes impactos na transformação da cidade. É na cidade de São Paulo que avanços e inovações científicas e tecnológicas encontram importante campo para sua aplicação, devido à existência de um complexo médico-hospitalar (hospitais, centro de atendimento básico e especializado, laboratórios, centros de diagnóstico, consultórios etc.) amplo e diversificado, com hospitais e serviços de alta complexidade e com certificações de excelência englobando a rede privada e a conveniada pelo Sistema Único de Saúde (SUS), com pesquisa e formação de profissionais especializados, tornando-se centro de referência no Brasil. Enquadram-se nesse cenário o Hospital das Clínicas (FMUSP) e o Hospital São Paulo (EPM-Unifesp), classificados como hospitais de alta complexidade, com ensino e pesquisa médico-científica.Throughout the ceaseless transformations the city of São Paulo went through, new objects and technical systems were constantly incorporated in the citys geographical space, reflecting the current hegemonic logic and, thus, old objects and technical systems became subordinated to renewed functions whose goals are to adapt to the constantly renewed logic of the production system. Meanwhile, medical practice and knowledge do not bypass this logic given that their development is entangled with scientific knowledge, ultimately resulting in an artificialized gaze in patient care. In this context, hospitals became the center of modern medicine, transforming itself in a specific economic activity and the place of health services consumption, furthermore they became a part of this urban logic, putting forward a set of technological changes that led to further impact in the city. Therefore, is in the city of São Paulo that technological changes and scientific innovations are mainly applied due to the presence of large medical care complexes (hospitals, health care centers, laboratories, clinics and etc.) with high complexity facilities that overarches the private and public sectors of healthcare, along with research and development in health care an the formation of specialized professionals, making the city a reference of health care in Brazil. In this context the Clínicas Hospital (FMUSP) and the São Paulo Hospital (EPM-Unifesp) are classified as high complexity hospitals equipped with school hospitals and medical research and development.
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Warde, Filho Mario Jorge [UNIFESP]. "Short Form-36, Escala de Auto-Estima Rosemberg/UNIFESP-EPM, Body Shape Questionnaire e Escala de Depressão de Beck na lipoatrofia facial de pacientes com HIV/AIDS, após implante de polimetilmetacrilato." Universidade Federal de São Paulo (UNIFESP), 2008. http://repositorio.unifesp.br/handle/11600/24182.
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Previous issue date: 2008Introdução: Com o advento da terapia anti-retroviral de alta potencia (TARV), a expectativa de vida do paciente com HIV/AIDS aumentou. A lipoatrofia facial é uma complicação comum nesses pacientes que, muitas vezes, os submete ao estigma e à segregação, assim como afeta negativamente a qualidade de vida. Objetivo: verificar o impacto do tratamento da lipoatrofia facial com o polimetilmetacrilato (PMMA) na qualidade de vida de pacientes com AIDS em tratamento com anti-retrovirais, medido por quatro questionários que traduzem qualidade de vida. Métodos: 40 pacientes com AIDS sob TARV com diagnóstico de lipoatrofia facial fizeram parte deste estudo. Os primeiros 20 pacientes foram para o Grupo Tratamento, e suas faces foram tratadas com PMMA. Os outros 20 pacientes foram alocados em um Grupo Controle, e foram tratados apenas seis meses depois, após o término do presente estudo. No momento zero, quatro questionários de qualidade de vida foram aplicados, como Medical Outcomes Study 36-Item ShortForm Health Survey (Short Form-36), a Escala de Auto-Estima Rosenberg/UNIFESP-EPM, Body Shape Questionnaire (BSQ) e o Inventário de Depressão de Beck. Esses questionários foram novamente aplicados seis meses depois para ambos os grupos, termino do estudo. Os escores obtidos foram comparados intragrupo e intergrupos através dos testes não paramétricos de Mann Whitney e Wilcoxon. Resultados: a variação dos escores obtidos no Grupo Tratamento para todos os questionários em todos os domínios foi significativamente diferente para melhor, quando confrontados com o Grupo Controle. Conclusão: Houve melhora na qualidade de vida do paciente com AIDS e lipoatrofia facial, quando tratados com PMMA.
Introduction: Life expectancy increased in patients infected with HIV/AIDS with the advent of highly active antiretroviral therapy. Facial lipoatrophy is a common complication in these patients, eventually leading to stigma, segregation and a negative impact in quality of life. Objective: to evaluate the impact of the treatment of facial lipoatrophy with poly-methyl-metha-acrylate (PMMA) in the quality of life of patients with aids, as measured by four questionnaires that address quality of life. Methods: Forty consecutive aids patients on HAART referred for facial lipoatrophy treatment were enrolled in this study. The first 20 were allocated to the intervention group and were treated with tissue augmentation with PMMA. The other 20 were allocated to the control group, which received treatment only after six months. At moment zero, four questionnaires were applied to all patients in both groups, namely, the Medical Outcomes Study 36-Item ShortForm Health Survey (SHORT FORM-36), The Self-Esteem Scale Rosemberg/UNIFESP-EPM, Body Shape Questionnaire and Beck Depression Inventory. The questionnaires were applied again in six months, that is, post-treatment in the intervention group, and pretreatment in the conttrol group. Scores were compared within and between groups with Mann-Whitney’s and Wilcoxon’s tests. Result: The variation in scores within the intervention group for all domains of all four instruments was significantly different for better when compared to that within the control group. Conclusion: We detected improvement in the quality of life of patients with aids and facial lipoatrophy, when they were treated with PMMA, as opposed to an untreated control group.
BV UNIFESP: Teses e dissertações
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Tea, Eric. "Résolution de l'equation de transport de boltzmann par une approche Monte Carlo (full-band), application aux cellules solaires à porteurs chauds et aux composants ultra-rapides." Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00670433.
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Cette thèse est consacrée à l'étude de la dynamique des porteurs de charges sous forte concentration. La méthode Monte Carlo " Full-Band " a été utilisée pour la modélisation du transport et la relaxtion des porteurs de charge dans les semi-conducteurs III-V (GaAs, InAs, GaSb, In0.53Ga0.47As et GaAs0.50Sb0.50). Les structures électroniques ont été calculées par la Méthode des Pseudo-potentiels Non-Locaux Empiriques, ce qui a notamment permis de traiter le cas de l'alliage ternaire GaAs0.50Sb0.50 dans une approche de type Cristal Virtuel, matériau qui souffre d'un manque de caractérisations expérimentales. Dans ces semi-conducteurs polaires fortement dopés, le couplage entre phonons optiques polaires et plasmons a été pris en compte via le calcul de la fonction diélectrique totale incluant les termes associés à l'amortissement dans le système phonon-plasmon auto-cohérents. Ce phénomène de couplage phonon-plasmon, est apparu primordial pour l'analyse de la mobilité des électrons dans GaAs, In0.53Ga0.47As et GaAs0.50Sb0.50 en fonction de la concentration en accepteurs. Dans des semi-conducteurs fortement photo-excités, la relaxation des électrons et des trous a été étudiée en tenant compte du chauffage de la population de phonon (qui ralentit la relaxation des porteurs) avec un modèle Monte Carlo dédié à la dynamique des phonons (Thèse de H. Hamzeh). L'étude a montré que le ralentissement de la relaxation dépend fortement des concentrations de porteurs photo-excités à cause du couplage phonon-plasmon dans ces matériaux. Les processus de génération et recombinaison de porteurs tels que l'absorption optique, la recombinaison radiative, l'ionisation par choc et les recombinaisons Auger, ont été implémentés. Les taux de génération et recombinaison associés sont calculés directement sur les distributions de porteurs modélisées, sans supposer des distributions à l'équilibre. Ces processus sont cruciaux pour l'optimisation de Cellules Solaires à Porteurs Chauds. Le photo-courant de ce type de cellule théorique à haut rendement de 3ème génération avec un absorbeur en In0.53Ga0.47As a été étudié.
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Solini, Laurent. "Faire sa peine à l'établissement pénitentiaire pour mineurs de Lavaur : sociologie des expériences de détention." Toulouse 3, 2012. https://buadistant.univ-angers.fr/login?url=https://www.cairn.info/faire-sa-peine-a-l-etablissement-penitentiaire--9791034603848.htm.
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Les recherches en sciences sociales s'intéressant à l'univers carcéral semblent, depuis peu, déplacer leur regard vers l'expérience carcérale du détenu dans l'objectif d'analyser son rapport à l'enfermement. L'incarcération constitue alors une épreuve. Le détenu positionné au centre d'un quotidien sous contraintes œuvre à l'amélioration de ses conditions de détention. La situation sociale particulière que constitue la période d'incarcération est alors appréhendée en tant que ligne biographique dominante ramenant à elle tous les autres centres d'intérêts de la vie quotidienne du détenu. Si ce déterminisme de l'incarcération a fait l'objet de recherches s'appuyant essentiellement sur des entretiens biographiques menés avec les détenus, peu d'études se sont intéressées à la manière dont ce rapport particulier à la peine d'emprisonnement se construit, au jour le jour, de surcroit chez une population mineure à l'intérieur d'une prison, présentée par les pouvoirs public comme novatrice : l'établissement pénitentiaire pour mineurs (EPM) de Lavaur. Notre travail de recherche porte sur les expériences de détention des mineurs incarcérés à l'intérieur d'un EPM. Une enquête ethnographique menée entre janvier 2008 et juin 2010 à l'EPM de Lavaur permet d'appréhender les expériences de détention au moyen d'une étude approfondie des logiques d'action construites par les détenus durant l'ensemble des temps collectifs mixtes auxquels ils sont sommés de participer. Dès lors, " faire sa peine " s'exprime, à l'EPM de Lavaur, dans l'instauration d'un rapport pratique à l'enfermement. Le détenu œuvre dans le but d'améliorer ses conditions de détention et bricole des espaces de liberté en manœuvrant avec l'hyperactivité forcée que lui inflige l'institution. Prié de partager l'ensemble des activités collectives, le jeune détenu, alors soumis à la surveillance des personnels ainsi qu'à l'observation des détenus (la persistance des regards étant renforcée par la configuration architecturale des lieux ménageant de nombreux espaces ouverts), s'engage dans une mise en scène de soi. Il fait ainsi la démonstration de certaines conduites, produits d'une culture importée en prison, et cherche à en camoufler d'autres dans le but de susciter la reconnaissance des acteurs présents. L'EPM de Lavaur est ainsi envisagé en tant que prison-scène. De ce point de vue, quatre figures de pratiques peuvent être extraites à partir d'une classification des logiques d'action construites par les détenus à l'intérieur des temps collectifs. Elles constituent alors les idéaux-types de conduites renvoyant à la mise en scène de façades personnelles idéalisées, l'adolescent s'attachant à maintenir ou à faire varier des rôles lui garantissant une meilleure position à l'intérieur des groupes formés lors des temps collectifsResearches in social sciences that deal with the penitentiary world seem recently to focus on the prison experiment of the inmate to analyze its relation to the imprisonment. Detention is then a test. The inmate that is subjected to daily constraints works in order to improve his conditions of detention. The particular social situation that constitutes the detention is then comprehended as a dominant biographical line bringing back with it all the other goals of the inmate's life. If this determinism of the incarceration has been subjected to researches based mainly on inmate biographical interviews, few studies focused on how is built this particular relation to the detention, day by day, in addition in a minor population within a prison, described as innovative by the government: the " établissement pénitentiaire pour mineurs " (EPM) of Lavaur (France). Our research focused on the experiments of detention of minor incarcerated in an EPM. An ethnographic investigation that was performed between January of 2008 and June of 2010 at the EPM of Lavaur allowed to comprehend the experiments of detention thanks to a comprehensive study of the logics of action built by inmate during the whole mixed collective times in which they participate. Therefore " faire sa peine " is expressed at the EPM of Lavaur in the establishment of a practice relation to the incarceration. The inmate works to improve his conditions of detention and builds spaces of freedom by operating with the compelled hyperactivity that is imposed by the institution. Asked to share the overall collective activities, the young inmate, submitted to the surveillance of the staff and to the observation of other inmates (the persistence of gazes is strengthened by the architectural sites leaving to many open spaces) engages him in a staged. Thus, he demonstrates some behaviors, resulting from an imported culture in prison, and seeks to hide other in order to raise the recognition of the actors present. The EPM of Lavaur is thus envisaged as a prison-stage. From this point of view, four figures of practices can be extracted from a classification of action logics build by inmates during the collective times. They are then the ideal types of behaviors referring to the staging of an ideal self-images, the teenager works to maintain or to vary the roles guaranteeing him a better position within the groups formed during the collective times
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Danielson, Kathryn, and Sean Ustic. "Characterization of the Signaling Properties of FLAG Tagged EP2 and EP4 Prostanoid Receptors." The University of Arizona, 2009. http://hdl.handle.net/10150/623990.
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Class of 2009 AbstractOBJECTIVES: To develop a novel characterization system utilizing immunofluorescent FLAG tagged EP2 and EP4 receptors to assist in the explanation of their unique cell signaling properties for exploitation in future drug development design. METHODS: Plasmids were obtained and isolated that contained cDNAs encoding FLAG-tagged EP2 and EP4 receptors for transient expression in HEK-293 cells. The sequences of these plasmids were confirmed by restriction enzyme analysis and DNA sequencing. Transfected cells were treated with vehicle, PGE2 or forskolin to assess appropriate receptor functionality based on cAMP induction. RESULTS: The two PGE2 receptor subtypes, EP2 and EP4, are similar in their activation of adenylyl cyclase (AC) and subsequent up regulation of cAMP production. These receptors differ, however, in that EP2 more efficiently stimulates cAMP production and EP4 signaling involves the activation of phosphatidylinositol 3-kinase (PI3K) and extracellular signal related kinases (ERKs). The PGE2- treated cells responded as predicted with intracellular production of cAMP, with the EP2 receptor responding more efficiently than the EP4 receptor. CONCLUSIONS: The intent is for these cells to be used as a novel assay system for the development of future selective EP2 and EP4 agonists. This research could potentially benefit in selectively targeting EP2 or EP4 pathways linked to prevalent ailments such as pain, fever, inflammation, possibly cancer or bone growth.
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Jeeva, Zakkiyya Igbal. "The role of monoamines in post traumatic stress disorder (PTSD) using a time dependent sensitization animal model / Zakkiyya Igbal Jeeva." Thesis, North-West University, 2004. http://hdl.handle.net/10394/587.
Full textAbstract:
Posttraumatic stress disorder (PTSD) is an anxiety disorder that may result from an exposure
to a severely traumatic life-event. It is characterised by a delayed onset of psychological and
physical symptoms including re-experiencing the event, avoidance of reminders associated with
the trauma, increased autonomic arousal and distinct memory deficits. This disorder is also
characterised by a maladaptive hypothalamic-pituitary-adrenal (HPA)-axis response and altered
monoamine concentrations in the hippocampus and pre-frontal cortex.
The Time Dependent Sensitization (TDS) model is a putative animal model of PTSD that is
based on the concept of repeated trauma, using three acute stressors (TS) of intense severity
followed by a mild situational reminder (RS) on day 7 subsequent to the acute stressors. The
aims of this study were to determine if the Triple Stressor (TS) induces stress and if the
situational reminder (RS) is necessary for the maintenance of the stress response over time and
whether these two stress responses are qualitatively and quantitively different. This was done to
further validate the TDS model and to characterize the development and progression of the
stress-related pathology of PTSD.
Methods used were High Performance Liquid Chromatography (HPLC) with electrochemical
detection (biochemical correlates) for quantifying the monoamines dopamine (DA),
noradrenaline (NA) and serotonin (5-HT) concentrations in the hippocampus and pre-frontal
cortex (PFC); radio immuno assay (RIA) for the determination of plasma corticosterone
concentrations (neuroendocrine parameter) and the use of the Elevated Plus Maze (EPM) to
detect anxiety-like behaviour (behavioural analyses).
The study was subdivided into an Acute and Re-Stress study (n = 10). In the Acute Study rats
were exposed to TS as the only stressor. Group 1 was sacrificed immediately after TS, Group 2
was sacrificed 3 days post TS and Group 3 on day 7 post TS. In the Re-Stress Study both TS
and RS were used as stressors. Group 4 was sacrificed immediately after the situational
reminder, Group 5 was sacrificed 3 days post RS and Group 6 on day 7 post RS. A group of
unstressed rats were used as Control.
The results of this study found corticosterone concentrations elevated immediately after the TS
(p<0.05). Exposure to the RS resulted in a profound hypocortisolism (p<0.05). These results
indicate a possible disturbance in the regulation of the HPA-axis, which manifests as an
enhanced negative feed-back upon re-introduction of the stressful situation.
Changes in MA concentrations were evident. Although no definite fixed trend is apparent in this
study, it is evident that the TDS model does induce monoamine dysregulation. Hippocampal
NA. DA and 5-HT concentrations were noted to be elevated on day 7 post TS (p<0.05). On day
7 post RS only hippocampal 5HT was decreased significantly (p<0.05).
Behavioural analyses indicate that stress related anxiety was not sustained after the TS but 7
days after the exposure to the RS rats were most anxious (p<0.05). The results confirm that the
TDS model does induce PTSD-like symptoms in rats and that the situational reminder (RS) is
necessary for the maintenance of the stress response. This model may be useful in the
investigation of future experimental pharmacological interventions in the management of PTSD.Thesis (M.Sc. (Pharmacology))--North-West University, Potchefstroom Campus, 2005.
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Thibodeau, Jean-François. "Prostaglandin E2 Signaling Through Kidney EP1 and EP4 Receptors; Implications in Diabetes and Hypertension." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32749.
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Chronic kidney disease is defined as the appearance of kidney functional or structural injury. Cyclooxygenase and prostaglandin E2 have been implicated in the pathogenesis of diabetic nephropathy, the leading cause of chronic kidney disease. Beneficial in certain settings, inhibition of the cyclooxygenase pathway can however be detrimental in patients with compromised cardiac or renal function. Moreover, the quest for new therapies to treat diabetic nephropathy is hampered by the lack of appropriate rodent models. This doctoral thesis is a culmination of three studies, the first to determine the role of the prostaglandin E2 EP1 receptor in diabetic nephropathy, the second to elucidate the vascular prostaglandin E2 EP4 receptor’s role in hypertension and lastly to establish and characterise a novel mouse model of diabetic nephropathy. The goal being to uncover new therapeutic avenues for the treatment of CKD, its causes and/or complications.
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Nunciato, Ana Claudia. "Efeito ansiolítico do ondansetron, antagonista dos receptores 5-HT3, injetado na amídala de camundongos submetidos à exposição e reexposição no labirinto em cruz elevado." Universidade Federal de São Carlos, 2011. https://repositorio.ufscar.br/handle/ufscar/1332.
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Previous issue date: 2011-03-02Financiadora de Estudos e Projetos
Against of stimuli that are dangerous, animals manifest defense reactions that cause fear and anxiety. These stimuli activate the serotonergic system, which sends projections to structures involved in defense mechanisms such as the septum, hypothalamus, hippocampus, amygdala and periaqueductal gray modulates the behavioral changes that can be characterized as anxiety. Studies have shown that 5-HT3 receptors are part of this modulation. The elevated plus maze (EPM) is a widely used animal model to evaluate the anxiolytic activity of drugs. Currently, it is known that the retest in rodents (rats and mice) increases the avoidance of it, this phenomenon, which refers to "a display of tolerance" (OTT, One Trial Tolerance). The amygdala is a prosencephalic structures that have significant amount of serotonin (5-HT) in this way, recent results from our laboratory have shown that microinjections of ondansetron antagonist 5-HT3 receptors in the amygdala of mice produced anxiolytic-like effect evaluated in LCE. The aim of this study was to evaluate the involvement of receptors 5-HT3 receptors in the amygdala of mice prior experience the elevated plus-maze (EPM). Conventional measures of anxiety (% of entry and time spent in open arms), locomotor activity (frequency in closed arms) and ethological measures related to risk assessment were recorded. The present study demonstrated that intra-amygdala of ondansetron, antagonist of 5-HT3 receptors, produced anxiolytic-like effects in naive mice and mice prior experience the LCE. The injection of ondansetron in only one of the exhibits produced anxiolytic-like effect, which leads us to conclude that the drug produced no change in memory. Both the Trial 1 and in Trial 2, none treatments affected locomotor activity. So while the amygdala is involved in the neurobiology of the defense reactions such as anxiety response, as it refers to the phenomenon it seems OTT not to participate.
Diante de estímulos que representam perigo os animais manifestam reações de defesa que originam o medo e a ansiedade. Estes estímulos ativam o sistema serotonérgico, o qual emite projeções para estruturas envolvidas nos mecanismos de defesa tais como, septo, hipotálamo, hipocampo, substância cinzenta periaquedutal e amídala, modulando as alterações comportamentais que podem ser caracterizadas como ansiedade. Estudos têm demonstrado que os receptores 5-HT3 fazem parte desta modulação. O labirinto em cruz elevado (LCE) é um modelo animal amplamente utilizado para avaliar a atividade ansiolítica de drogas. Atualmente, sabe-se que o reteste em roedores (ratos e camundongos) aumenta a evitação do mesmo, fenômeno este, que se refere à tolerância de uma exposição (OTT, do inglês One Trial Tolerance). A amídala é uma das estruturas prosencefálicas que apresentam quantidade relevante de serotonina (5-HT), dessa forma, resultados recentes do nosso laboratório demonstram que microinjeções de ondansetron, antagonista dos receptores 5- HT3, na amídala de camundongos, produziu efeito ansiolítico avaliado no LCE. O objetivo deste estudo foi avaliar o envolvimento dos receptores 5-HT3 na amídala de camundongos reexpostos ao labirinto em cruz elevado (LCE). Medidas convencionais de ansiedade (% de entrada e de tempo gasto nos braços abertos), atividade locomotora (freqüência de entrada nos braços fechados) e medidas etológicas relacionadas à avaliação de risco foram registradas. O presente estudo demonstrou que a injeção intra-amídala de ondansetron, antagonista de receptores 5-HT3, produziu efeito ansiolítico tanto em camundongos ingênuos quanto em camundongos reexpostos ao LCE. A injeção de ondansetron em apenas uma das exposições produziu efeito ansiolítico, o que nos leva a concluir que a droga não produziu alteração da memória. Tanto na exposição 1 como na reexposição, nenhum dos tratamentos afetou a atividade locomotora. Portanto, embora a amídala esteja envolvida na neurobiologia das reações de defesa, tais como a resposta de ansiedade, no que se que refere ao fenômeno OTT ela parece não participar.
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Myburgh, Jacolene. "A pharmacokinetic-pharmacodynamic relationship study between GABA-ergic drugs and anxiety levels in an animal model of PTSD / Jacolene Myburgh." Thesis, North-West University, 2005. http://hdl.handle.net/10394/1320.
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Reschke, Cristina Ruedell. "RECEPTORES EP1 E EP3 MODULAM AS CRISES EPILÉPTICAS INDUZIDAS POR PENTILENOTETRAZOL E ÁCIDO CAÍNICO EM CAMUNDONGOS." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/3852.
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Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorEpilepsy is one of the most common neurologic disorders. It has been suggested that seizures may be facilitaded by inflammation. PGE2 is one of the most important inflammatory mediators, and facilitates pentylenetetrazol (PTZ)-induced seizures by stimulating EP1 and EP3 receptors. However, up to the present moment, no study has investigated whether EP1 and EP3 receptors blocking attenuate seizures induced by convulsants other than PTZ. It is also unknown whether Na+,K+-ATPase activity alterations are involved in such an effect. Therefore, in the current study we investigated whether EP1 and EP3 ligands (agonists and antagonists) modulate PTZ- and kainic acid (KA)-induced seizures, and whether alterations in Na+,K+-ATPase activity mediate such a protective effect, in mice. EP1 and EP3 antagonists (ONO-8713 and ONO-AE3-240, respectively, 10 Og/kg, s.c.) attenuated PTZ (60 mg/kg, i.p.)- and KA (20 mg/kg, i.p.)-induced seizures. The respective agonists (ONO-DI-004 and ONO-AE-248, 10 Og/kg, s.c.) facilitated seizures in both acute models, and at noneffective doses, prevented the protective effects of the antagonists. Animals injected with PTZ presented decreased Na+,K+-ATPase activity in the cerebral cortex and hippocampus. On the other hand, animals injected with KA presented increased Na+,K+-ATPase activity in the same cerebral structures at the end of the experiment. These divergent findings suggest that alterations in Na+,K+-ATPase activity in both acute models depends on the convulsant agent used and make difficult to establish a relationship between Na+,K+-ATPase activity and seizure development. Moreover, EP1 and EP3 antagonists administration abolished Na+,K+- ATPase activity alterations induced by PTZ and KA, in such a way that these alterations seem to be related more to the presence of ictal phenomenon itself than to the seizure induction mechanisms. Notwithstanding, the currrent results clearly show that EP1 and EP3 receptors might constitute novel targets for anticonvulsants development, since EP1 and EP3 decreased seizures, regardless of the convulsant agent used.
A epilepsia é uma das disfunções neurológicas mais comuns. Tem sido sugerido que as crises epilépticas podem ser facilitadas pela ocorrência de inflamação. A PGE2 é um dos mediadores inflamatórios mais importantes que, agindo por meio dos receptores EP1 e EP3, facilita as convulsões induzidas por pentilenotetrazol (PTZ). Contudo, até a presente data, nenhum estudo investigou, de maneira sistêmica, se a ativação ou bloqueio de receptores EP1 e EP3 facilitam as convulsões induzidas por outros agentes; tampouco se alterações na atividade da Na+,K+-ATPase estão envolvidas nesse efeito. Assim, no presente estudo, investigamos se ligantes (agonistas e antagonistas) de receptores EP1 e EP3 modificam as crises induzidas por PTZ e ácido caínico (KA), e se tais efeitos estão associados a alterações na atividade da enzima Na+,K+-ATPase, em camundongos. Os antagonistas EP1 e EP3 (ONO-8713 e ONO-AE3-240, respectivamente, 10 Og/Kg, s.c.) atenuaram as convulsões induzidas por PTZ (60 mg/Kg, i.p.) e KA (20 mg/Kg). Os seus respectivos agonistas (ONO-DI-004 e ONO-AE-248 de 10 Og/Kg, s.c.) facilitaram as convulsões em ambos modelos agudos de crises epilépticas e, em doses não efetivas para gerar crises, preveniram os efeitos dos antagonistas. Os animais submetidos à administração de PTZ apresentaram, ao final do experimento, a atividade Na+,K+-ATPásica diminuída no córtex cerebral e hipocampo. Por outro lado, animais tratados com KA apresentaram um aumento na atividade Na+,K+-ATPásica nestas mesmas estruturas, que se correlacionou positivamente com a vigência de status epilepticus no momento do sacrifício. Os achados divergentes no que diz respeito à alteração da atividade da Na+,K+-ATPase nos dois modelos de crises agudas sugere que tais alterações estejam relacionadas ao tipo de agente convulsivante utilizado, e dificultam estabelecer, de forma inequívoca, uma relação entre atividade desta ATPase e sensibilidade à crises agudas. Ademais, a administração de antagonistas EP1 e EP3 aboliu as alterações da atividade da Na+,K+-ATPase induzidas tanto por PTZ como por KA, de tal forma que estas parecem estar mais associadas com o fenômeno ictal em si, do que com os mecanismos de indução da crise. Contudo, os resultados mostram de forma clara que os receptores EP1 e EP3 podem se constituir possíveis novos alvos para o desenvolvimento de drogas antiepilépticas, pois antagonistas EP1 e EP3 diminuíram as crises, independente do agente convulsivante utilizado.
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Zamarrenho, Luana Gonçalves. "Efeito do chá de ayahuasca sobre o comportamento de ratos Wistar no campo aberto e labirinto em cruz elevado e sobre a expressão de EAAC1 no hipocampo e córtex pré-frontal." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/59/59134/tde-17102014-103415/.
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O objetivo do presente estudo foi avaliar se ratos tratados com chá de ayahuasca apresentam i) alterações comportamentais no campo aberto e labirinto em cruz elevado (LCE); ii) alterações na expressão do transportador de glutamato (EAAC1) no córtex pré-frontal (CPF) e no hilus do giro denteado do hipocampo (HDG). Doze grupos de ratos Wistar machos (250g, n=10/cada) foram usados. Eles receberam 2 or 4ml/Kg de chá de ayahuasca ou água: dose única (agudo), 3 vezes/dia por 3 dias alternados (subcrônico) e 1 vez/dia por 15 dias (crônico). Trinta minutos após a última ingestão os animais foram submetidos aos testes comportamentais. Vinte e quatro horas após eles foram anestesiados, perfundidos e seus encéfalos seccionados (40-m) no hipocampo e CPF para os experimentos de imunoistoquimica para EAAC1. Comparações estatísticas entre cada grupo tratado com ayahuasca e seu respectivo controle foram feitas utilizando o teste t de Student e consideradas significantes quando p0,05. Apenas a ingestão subcrônica de ayahuasca induziu redução significante na atividade locomotora (27%) no campo aberto. No LCE nenhum dos tratamentos com ayahuasca induziu alterações significantes em ambos numero de entradas e tempo de permanência nos braços abertos. A ingestão subcrônica ou crônica de chá de ayahuasca induziu aumento significante na expressão de EAAC1 no HGD (20-67%). Em contraste, no CPF a expressão de EAAC1 foi significantemente reduzida em ratos tratados com 2 ou 4ml/Kg subcronicamente ou 4ml/Kg cronicamente (17-25%). A ingestão aguda de 2ml/Kg induziu discreto aumento na expressão de EAAC1 (16%). Estes resultados sugerem que i) Ayahuasca induz alterações nas atividades locomotora e exploratória de forma dependente da dose e frequência de ingestão; ii) Ayahuasca não tem efeito no nível de ansiedade; iii) A ingestão aguda, subcrônica e subcrônica de ayahuasca disparam distintos mecanismos no hipocampo e CPF envolvendo a modulação da neurotransmissão glutamatérgica.This work aimed at investigating whether rats treated with Ayahuasca beverage show i) behavioral alterations in the open field and elevated plus maze (EPM); ii) alterations in the expression of glutamate transporter (EAAC1) in the prefrontal cortex (PFC) and in the hilus of dentate gyrus of the hippocampus (HDG). Twelve groups of male Wistar rats (250g, n=10/each) were used. They received 2ml/Kg or 4ml/Kg of ayauhasca beverage or water: only once (acute), 3 times/day for 3 days (sub-chronic) or once/day for 15 days (chronic). Thirty minutes after the last ingestion the animals were submitted to behavioural tests. After 24 hours they were anaesthetized, perfused and their brains sectioned (40-m) in the hippocampus and PFC for immunohistochemistry (IH) detection of EAAC1. Comparisons between ayahuasca and control groups used Student t test. Significance was set at p0.05. Only sub-chronic ingestion of Ayahuasca induced a decrease in locomotor (27%) activit in the open field. On the EPM all treatments with Ayahuasca induced no significant increase in both number of entries and time spent in the open arms. The sub-chronic and chronic treatments with Ayahuasca induced a significant increase in EAAC1 expression in the HDG (20-67%). In contrast, in the PFC the expression of EAAC1 was significantly decreased in rats treated with 2 or 4ml/Kg sub-chronically or 4ml/Kg chronically (17-25%). Acute ingestion of 2ml/Kg induced a smaller increase in EAAC1-IC (16%). These results suggest that i) Ayahuasca changes the locomotor and exploratory activities in a way depending the dose and frequency of ingestion; ii) Ayahuasca does not have effect on the level of anxiety; iii) Acute, sub-chronic or chronic ingestion of Ayahuasca beverage trigger distinct mechanisms in the PFC and hippocampus involving the modulation of glutamate neurotransmission.
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Chandra, Divya. "To evaluate differences in mRNA expression of c-fms, EP2 and EP4 between large and small osteoclasts." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ62999.pdf.
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Miyamoto, Masatomo. "Simultaneous stimulation of EP2 and EP4 is essential to the effect of prostaglandin E2 in chondrocyte differentiation." Kyoto University, 2004. http://hdl.handle.net/2433/147477.
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Honda, Tetsuya. "Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis." Kyoto University, 2007. http://hdl.handle.net/2433/135661.
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