Relevant bibliographies by topics / Epigenetics

Academic literature on the topic 'Epigenetics'

Author: Grafiati
Published: 4 June 2021
Last updated: 31 August 2024

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Journal articles on the topic "Epigenetics"

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Faiq Rzayeva, Faxranda. "Epigenetik mexanizm və Parkinson xəstəliyi arasındakı əlaqələrin kliniki əhəmiyyəti." NATURE AND SCIENCE 17, no. 2 (February 18, 2022): 11–13. http://dx.doi.org/10.36719/2707-1146/17/11-13.

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Today, epigenetics is more commonly used for heritable changes in gene expression. While no change is observed in the DNA sequence, chromatin changes such as DNA methylation, histone modification, and nucleosome positioning cause epigenetic events (10). Epigenetic processes; DNA includes chemical modifications of histones and various coding and non-coding RNAs. In recent years, the role of epigenetics in neuroscience has been extensively explored, thanks to technological advances. Therefore, the term “neuroepigenetics” appeared in PubMed in 2009 and is widely used today. Key words: Parkinson's disease, α-synuclein, mutation, neurons, dopaminergic, DNA Epigenetik mexanizm və Parkinson xəstəliyi arasındakı əlaqələrin kliniki əhəmiyyəti Xülasə Bu gün epigenetika gen ifadəsindən irsi dəyişikliklər üçün daha çox istifadə olunur. DNT ardıcıllığında heç bir dəyişiklik müşahidə edilməsə də, DNT metilasiyası, histon modifikasiyası və nukleosomların yerləşdirilməsi kimi xromatin dəyişiklikləri epigenetik hadisələrə səbəb olur (10). Epigenetik proseslər; DNT histonların kimyəvi modifikasiyalarını və müxtəlif kodlaşdıran və kodlaşdırmayan RNT-ləri özündə əks etdirir. Son illərdə texnoloji tərəqqi sayəsində epigenetikanın nevrologiyada rolu geniş şəkildə tədqiq edilmişdir. Buna görə də “neyroepigenetika” termini 2009-cu ildə PubMed-də yaranıb və bu gün geniş istifadə olunur. Açar sözlər: Parkinson xəstəliyi, α-sinuklein, mutasiya, neyronlar, dopaminerjik, DNT
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Ktori, Sophia. "Elevating Epigenetics: Cambridge Epigenetics and NuGEN Form Epigenetic Marker Partnership." Clinical OMICs 4, no. 5 (September 2017): 16–17. http://dx.doi.org/10.1089/clinomi.04.05.14.

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Vokhmyanina, N. V. "Epigenetics and multifactorial diseases." Russian Journal for Personalized Medicine 3, no. 6 (January 16, 2024): 42–49. http://dx.doi.org/10.18705/2782-3806-2023-3-6-42-49.

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At present, epigenetics is being studied in detail and actively, and the significance of epigenetics in the development of multifactorial diseases has been determined. In this regard, a large number of publications have recently appeared that analyze the results of studies using epigenetic markers. The obtained promising results indicate the possibility of early detection and prediction of many multifactorial diseases. This review briefly outlines the theoretical foundations of epigenetics and epigenetic mechanisms. The participation of epigenetics in the formation of multifactorial pathology is considered on the example of celiac disease, multiple sclerosis and cardiovascular diseases, confirmed by the identified epigenetic markers.
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Papakonstantinou, Eleni, Konstantina Dragoumani, George P. Chrousos, and Dimitrios Vlachakis. "Exosomal Epigenetics." EMBnet.journal 29 (May 22, 2024): e1049. http://dx.doi.org/10.14806/ej.29.0.1049.

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Epigenetics is the study of heritable changes in gene expression that occur without changes to the underlying DNA sequence. Epigenetic modifications can include DNA methylation, histone modifications, and non-coding RNAs, among others. These modifications can influence the expression of genes by altering the way DNA is packaged and accessed by transcriptional machinery, thereby affecting cellular function and behavior. Epigenetic modifications can be influenced by a variety of factors, including environmental exposures, lifestyle factors, and aging, whilst abnormal epigenetic modifications have been implicated in a range of diseases, including cancer, neurodegenerative disorders, and cardiovascular disease. The study of epigenetics has the potential to provide new insights into the mechanisms of disease and could lead to the development of new diagnostic and therapeutic strategies. Exosomes can transfer epigenetic information to recipient cells, thereby influencing various physiological and pathological processes, and the identification of specific epigenetic modifications that are associated with a particular disease could lead to the development of targeted therapies that restore normal gene expression patterns. In recent years, the emerging role of exosomal epigenetics in human breast milk, highlighting its significance in infant nutrition and immune development. Milk exosomes are shown to carry epigenetic regulators, including miRNAs and long non-coding RNAs, which can modulate gene expression in recipient cells. These epigenetic modifications mediated by milk exosomal RNAs have implications for the development of the gastrointestinal tract, immune system, and metabolic processes in infants.
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Eirin-Lopez, Jose M., and Hollie M. Putnam. "Marine Environmental Epigenetics." Annual Review of Marine Science 11, no. 1 (January 3, 2019): 335–68. http://dx.doi.org/10.1146/annurev-marine-010318-095114.

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Marine organisms’ persistence hinges on the capacity for acclimatization and adaptation to the myriad of interacting environmental stressors associated with global climate change. In this context, epigenetics—mechanisms that facilitate phenotypic variation through genotype–environment interactions—are of great interest ecologically and evolutionarily. Our comprehensive review of marine environmental epigenetics guides our recommendations of four key areas for future research: the dynamics of wash-in and wash-out of epigenetic effects, the mechanistic understanding of the interplay of different epigenetic marks and the interaction with the microbiome, the capacity for and mechanisms of transgenerational epigenetic inheritance, and the evolutionary implications of the interaction of genetic and epigenetic features. Emerging insights in marine environmental epigenetics can be applied to critical issues such as aquaculture, biomonitoring, and biological invasions, thereby improving our ability to explain and predict the responses of marine taxa to global climate change.
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Manev, Hari, and Svetlana Dzitoyeva. "Progress in mitochondrial epigenetics." BioMolecular Concepts 4, no. 4 (August 1, 2013): 381–89. http://dx.doi.org/10.1515/bmc-2013-0005.

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AbstractMitochondria, intracellular organelles with their own genome, have been shown capable of interacting with epigenetic mechanisms in at least four different ways. First, epigenetic mechanisms that regulate the expression of nuclear genome influence mitochondria by modulating the expression of nuclear-encoded mitochondrial genes. Second, a cell-specific mitochondrial DNA content (copy number) and mitochondrial activity determine the methylation pattern of nuclear genes. Third, mitochondrial DNA variants influence the nuclear gene expression patterns and the nuclear DNA (ncDNA) methylation levels. Fourth and most recent line of evidence indicates that mitochondrial DNA similar to ncDNA also is subject to epigenetic modifications, particularly by the 5-methylcytosine and 5-hydroxymethylcytosine marks. The latter interaction of mitochondria with epigenetics has been termed ‘mitochondrial epigenetics’. Here we summarize recent developments in this particular area of epigenetic research. Furthermore, we propose the term ‘mitoepigenetics’ to include all four above-noted types of interactions between mitochondria and epigenetics, and we suggest a more restricted usage of the term ‘mitochondrial epigenetics’ for molecular events dealing solely with the intra-mitochondrial epigenetics and the modifications of mitochondrial genome.
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Pathak, Ayush, Sarthak Tomar, and Sujata Pathak. "Epigenetics and Cancer: A Comprehensive Review." Asian Pacific Journal of Cancer Biology 8, no. 1 (March 16, 2023): 75–89. http://dx.doi.org/10.31557/apjcb.2023.8.1.75-89.

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Cancer is a disease with extraordinary clinical significance, with much of medical research being devoted to it. Innumerable factors are relevant in fully understanding cancer but the epigenetic aspect stands out. Epigenetics is the study of changes, often germ-line, to the genome affecting the gene expression by silencing certain genes and modifying the gene expression. The three primary mechanisms for epigenetic changes are DNA methylation, histone modification and non-coding RNA (ncRNA) associated gene silencing. While epigenetics is a pivotal mechanism for the regular maintenance of a myriad of processes- including in cell differentiation and adaptability- aberrant epigenetic changes can lead to depreciated/altered gene function which may ultimately culminate in cancer. Consequently, the connection between epigenetics and cancer has been intensely studied over the past two decades and has generated substantial clinical data attesting to the efficacy of epigenetics as a viable approach to understand cancer progression or therapy. In this review, we look at the fundamental epigenetic principles, the changes in the epigenome which can often be a precursor to cancer, analyse the increasingly important role of epigenetics in decoding carcinogenesis, explore the latest advancements in use of epigenetics in cancer therapy and how the reversible nature of these epigenetic changes have changed the way we approach cancer therapy.
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Peixoto, Paul, Pierre-François Cartron, Aurélien A. Serandour, and Eric Hervouet. "From 1957 to Nowadays: A Brief History of Epigenetics." International Journal of Molecular Sciences 21, no. 20 (October 14, 2020): 7571. http://dx.doi.org/10.3390/ijms21207571.

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Due to the spectacular number of studies focusing on epigenetics in the last few decades, and particularly for the last few years, the availability of a chronology of epigenetics appears essential. Indeed, our review places epigenetic events and the identification of the main epigenetic writers, readers and erasers on a historic scale. This review helps to understand the increasing knowledge in molecular and cellular biology, the development of new biochemical techniques and advances in epigenetics and, more importantly, the roles played by epigenetics in many physiological and pathological situations.
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Rahman, Md, HM Jamil, Naznin Akhtar, Rashedul Islam, Md Rana, SM AbdulAwal, and SM Asaduzzaman. "Cancer epigenetics and epigenetical therapy." Journal of Experimental and Integrative Medicine 6, no. 3 (2016): 143. http://dx.doi.org/10.5455/jeim.270616.rw.016.

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Peedicayil, Jacob. "Pharmacoepigenetics and Pharmacoepigenomics: An Overview." Current Drug Discovery Technologies 16, no. 4 (December 11, 2019): 392–99. http://dx.doi.org/10.2174/1570163815666180419154633.

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Background: The rapid and major advances being made in epigenetics are impacting pharmacology, giving rise to new sub-disciplines in pharmacology, pharmacoepigenetics, the study of the epigenetic basis of variation in response to drugs; and pharmacoepigenomics, the application of pharmacoepigenetics on a genome-wide scale. Methods: This article highlights the following aspects of pharmacoepigenetics and pharmacoepigenomics: epigenetic therapy, the role of epigenetics in pharmacokinetics, the relevance of epigenetics to adverse drug reactions, personalized medicine, drug addiction, and drug resistance, and the use of epigenetic biomarkers in drug therapy. Results: Epigenetics is having an increasing impact on several areas of pharmacology. Conclusion: Pharmacoepigenetics and pharmacoepigenomics are new sub-disciplines in pharmacology and are likely to have an increasing impact on the use of drugs in clinical practice.
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Dissertations / Theses on the topic "Epigenetics"

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Sandhu, Kuljeet. "Networks in epigenetics /." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-876-1/.

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Bagacean, Cristina. "Epigenetics in leukemia." Thesis, Brest, 2018. http://www.theses.fr/2018BRES0012.

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Les dérivés de la cytosine sont d’importantes modifications épigénétiques dont le rôle dans l’évolution de la leucémie lymphoïde chronique (LLC) n’est pas totalement exploré. Dans ce contexte, notre première étude vise à examiner le niveau global de la 5-methylcytosine (5-mCyt), 5-hydroxymethylcytosine (5-hmCyt), 5-carboxylcytosine (5-CaCyt) et 5-hydroxymethyluridine (5-hmU) dans des lymphocytes B purifiés de patients LLC (n=56) et d’individus sains (n=17). Les principaux acteurs de la régulation épigénétique (DNMT1/3A/3B, MBD2/4, TET1/2/3, SAT1) ont été évalués par PCR quantitative en temps réel. L’analyse a permis de mettre en exergue trois groupes de patients. En premier lieu, un groupe de patients stables (délai médian de progression [PFS] et délai au premier traitement [TFT] >120 mois), avec un profil épigénétique similaire au groupe contrôle. Deuxièmement, un groupe intermédiaire (PFS=84; TFT=120 mois) qui présente une augmentation de la déméthylation de l’ADN expliquée par l'induction SAT1 / TET2 pendant la progression de la maladie. Troisièmement, un groupe de patients avec une forme active de la maladie (PFS=52; TFT=112 mois) qui présentent une hyperlymphocytose, une réduction du temps de doublement des lymphocytes et des modifications épigénétiques majeures. Au sein de ce groupe, une réduction est observée pour la 5-mCyt, 5-hmCyt, 5-CaCyt et serait associée à une diminution des DNMTs, TETs et MBDs au cours de la progression de la maladie. Les profils épigénétiques mis en évidence sont indépendants du statut mutationnel IGHV mais sont associés avec les anomalies cytogénétiques. Nous nous sommes également intéressés à cette association et nous avons montré dans la deuxième étude que les modifications des dérivées de la cytosine peuvent affiner le pouvoir pronostic des anomalies cytogénétiques. En conclusion, nos résultats suggèrent que les variations de la méthylation ainsi que des intermédiaires de la déméthylation de l’ADN sont impliqués dans la progression de la LLC
Cytosine derivatives are important epigenetic modifications whose role in the pathogenesis and evolution of chronic lymphocytic leukemia (CLL) is not fully explored. In this context, our first study aims to examine the global DNA level of 5-methylcytosine (5-mCyt), 5-hydroxymethylcytosine (5-hmCyt), 5-carboxylcytosine (5-CaCyt) and 5-hydroxymethyluridine (5-hmU) in purified B lymphocytes of CLL patients (n = 56) and healthy individuals (n = 17). The main actors in epigenetic regulation (DNMT1 / 3A / 3B, MBD2 / 4, TET1 / 2/3, SAT1) were evaluated by quantitative real time PCR. The analysis highlighted three groups of patients. First, a group of patients with stable disease (median time to progression [PFS] and time to first treatment [TFT]> 120 months), with an epigenetic profile similar to the control group. Secondly, an intermediate group (PFS = 84, TFT = 120 months) which shows an increase in DNA demethylation explained by SAT1 / TET2 induction during disease progression. Third, a group of patients with an active form of the disease (PFS = 52, TFT = 112 months) who have hyperlymphocytosis, a short lymphocyte doubling time, and major epigenetic changes. Within this group, a reduction is observed for 5-mCyt, 5-hmCyt, 5-CaCyt which is associated with a decrease in DNMTs, TETs and MBDs during disease progression. The identified epigenetic profiles are independent of IGHV mutational status but are associated with cytogenetic abnormalities. We were also interested in this association and we showed in the second study that modifications of cytosine derivatives levels can refine the prognostic power of cytogenetic abnormalities.In conclusion, our results suggest that methylation variations as well as DNA demethylation intermediates are involved in the progression of CLL
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Sun, Di. "Epigenetics in nasopharyngeal carcinoma /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7357-032-X/.

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Glastad, Karl M. "Epigenetics in social insects." Diss., Georgia Institute of Technology, 2016. http://hdl.handle.net/1853/54926.

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Virtually all multicellular organisms are capable of developing differently in response to environmental variation. At the molecular level, such developmental plasticity requires interpretation and perpetuation of environmental signals without changing the underlying genotype. Such non-genetic, heritable information is known as epigenetic information. This dissertation examines epigenetic information among social insects, and how differences in such information relate to phenotypic caste differences. The studies included herein primarily focus on one form of epigenetic information: DNA methylation. In particular, these studies explore DNA methylation as it relates to and impacts (i) alternative phenotype and particular gene expression differences in two social insect species, (ii) histone modifications, another important form of epigenetic information, in insect genomes, and (iii) molecular evolutionary rate of underlying actively transcribed gene sequences. We find that DNA methylation exhibits marked epigenetic and evolutionary associations, and is associated with alternative phenotype in multiple insect species. Thus, DNA methylation is emerging as one important epigenetic mediator of phenotypic plasticity in social insects.
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Wright, Alan. "Bayesian pathway analysis in epigenetics." Thesis, University of Plymouth, 2013. http://hdl.handle.net/10026.1/1286.

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A typical gene expression data set consists of measurements of a large number of gene expressions, on a relatively small number of subjects, classified according to two or more outcomes, for example cancer or non-cancer. The identification of associations between gene expressions and outcome is a huge multiple testing problem. Early approaches to this problem involved the application of thousands of univariate tests with corrections for multiplicity. Over the past decade, numerous studies have demonstrated that analyzing gene expression data structured into predefined gene sets can produce benefits in terms of statistical power and robustness when compared to alternative approaches. This thesis presents the results of research on gene set analysis. In particular, it examines the properties of some existing methods for the analysis of gene sets. It introduces novel Bayesian methods for gene set analysis. A distinguishing feature of these methods is that the model is specified conditionally on the expression data, whereas other methods of gene set analysis and IGA generally make inferences conditionally on the outcome. Computer simulation is used to compare three common established methods for gene set analysis. In this simulation study a new procedure for the simulation of gene expression data is introduced. The simulation studies are used to identify situations in which the established methods perform poorly. The Bayesian approaches developed in this thesis apply reversible jump Markov chain Monte Carlo (RJMCMC) techniques to model gene expression effects on phenotype. The reversible jump step in the modelling procedure allows for posterior probabilities for activeness of gene set to be produced. These mixture models reverse the generally accepted conditionality and model outcome given gene expression, which is a more intuitive assumption when modelling the pathway to phenotype. It is demonstrated that the two models proposed may be superior to the established methods studied. There is considerable scope for further development of this line of research, which is appealing in terms of the use of mixture model priors that reflect the belief that a relatively small number of genes, restricted to a small number of gene sets, are associated with the outcome.
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Dias, Renuka. "Epigenetics of Silver-Russell syndrome." Thesis, Queen Mary, University of London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.545985.

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Hoffman, Elizabeth. "Epigenetics and genetics of ageing." Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396775.

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Gensous, Noemie Elise <1987&gt. "Epigenetics of nutrition in aging." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amsdottorato.unibo.it/9210/1/Thesis_Final_Noe%CC%81mie_Gensous.pdf.

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There is a need to identify factors that are able to influence health in old age and to develop interventions that could slow down the process of aging and its associated pathologies. Lifestyle modifications, and especially nutrition, appear to be promising strategies to promote healthy aging. Their impact on aging biomarkers has been poorly investigated. In the first part of this work, we evaluated the impact of a one-year Mediterranean-like diet, delivered within the framework of the NU-AGE project in 120 elderly subjects, on epigenetic age acceleration measures assessed with Horvath’s clock. We observed a rejuvenation of participants after nutritional intervention. The effect was more marked in the group of Polish females and in subjects who were epigenetically older at baseline. In the second part of this work, we developed a new model of epigenetic biomarker, based on a gene-targeted approach with the EpiTYPER® system. We selected six regions of interest (associated with ELOVL2, NHLRC1, SIRT7/MAFG, AIM2, EDARADD and TFAP2E genes) and constructed our model through a ridge regression analysis. In controls, estimation of chronological age was accurate, with a correlation coefficient between predicted and chronological age of 0.92 and a mean absolute deviation of 4.70 years. Our model was able to capture phenomena of accelerated or decelerated aging, in Down syndrome subjects and centenarians and offspring respectively. Applying our model to samples of the NU-AGE project, we observed similar results to the ones obtained with the canonical epigenetic clock, with a rejuvenation of the individuals after one-year of nutritional intervention. Together, our findings indicate that nutrition can promote epigenetic rejuvenation and that epigenetic age acceleration measures could be suitable biomarkers to evaluate their impact. We demonstrated that the effect of the dietary intervention is country-, sex- and individual-specific, thus suggesting the need for a personalized approach to nutritional interventions.
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Aung, Hnin Thanda. "The importance of epigenetics in mammals /." [St. Lucia, Qld.], 2006. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19398.pdf.

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Barkas, Nikolaos. "Epigenetics in gene expression and development." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/epigenetics-in-gene-expression-and-development(4ca792fa-234e-4a6b-ac8e-bc9cc1fc7bc7).html.

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Epigenetic processes are known to play an important role in the regulation of embry-onic development and gene expression. Here we utilise next-generation sequencing and bioinformatics methodologies to investigate the role of epigenetics in two different sys-tems, heart and brain. In heart, the endocardium is a distinct understudied epithelial population of cells that is involved in directing morphogenesis of the myocardium, valve leaflets and trabeculae. We generate whole-genome bisulphite sequencing data for the endocardium and endothelium and compare these data to transcriptomic profiles of these cells. We identify a plethora of differentially expressed genes and differentially methylated genomic regions. Through motif analysis we identify the ETS family of transcriptional activators as likely to play a role in the development of the endocardium. In brain, we investigate the role of the CTCF and cohesin DNA binding factors in imprinted gene expression by performing high depth allele-specific ChIP-seq for these two factors. We develop a novel bioinformatics approach for performing allele-specific mapping of next-generation sequencing reads and we compare our results with existing data for mouse liver and embryonic stem cells. We note that embryonic stem cells have fewer unique CTCF binding sites consistent with their undifferentiated profile. We examine CTCF and cohesin binding in the vicinity of imprinted loci and note that CTCF and/or cohesin bind to a subset of imprinted regions, suggesting a heterogeneous mechanism for imprinting. Collectively, our studies examine the role of epigenetics and their interplay with tran-scription in two distinct systems and identify a variable role for these processes in gene expression and development.
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Books on the topic "Epigenetics"

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Heil, Reinhard, Stefanie B. Seitz, Harald König, and Jürgen Robienski, eds. Epigenetics. Wiesbaden: Springer Fachmedien Wiesbaden, 2017. http://dx.doi.org/10.1007/978-3-658-14460-9.

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Bruce, Stillman, Stewart, David J., Ph.D., and Cold Spring Harbor Laboratory, eds. Epigenetics. Cold Spring Harbor, N.Y: Cold Spring Harbor Laboratory, 2004.

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Jörg, Tost, ed. Epigenetics. Norfolk, UK: Caister Academic Press, 2008.

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Jörg, Tost, ed. Epigenetics. Norfolk, UK: Caister Academic Press, 2008.

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David, Allis C., Jenuwein Thomas, and Reinberg Danny, eds. Epigenetics. Cold Spring Harbor, N.Y: Cold Spring Harbor Laboratory Press, 2007.

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Derek, Chadwick, and Cardew Gail, eds. Epigenetics. Chichester: Wiley, 1998.

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Khatib, Hasan. Livestock epigenetics. Hoboken: Wiley-Blackwell, 2012.

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Tollefsbol, Trygve O. Epigenetics Protocols. New Jersey: Humana Press, 2004. http://dx.doi.org/10.1385/1592598285.

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Haggarty, Paul, and Kristina Harrison, eds. Population Epigenetics. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6903-6.

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Dumitrescu, Ramona G., and Mukesh Verma, eds. Cancer Epigenetics. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-612-8.

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Book chapters on the topic "Epigenetics"

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Mathers, John C. "Epigenetics." In Nutrition Research Methodologies, 212–24. Chichester, UK: John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781119180425.ch14.

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Carlberg, Carsten, and Ferdinand Molnár. "Epigenetics." In Mechanisms of Gene Regulation: How Science Works, 99–113. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-52321-3_7.

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Jain, Rajan, Mudit Gupta, and Jonathan A. Epstein. "Epigenetics." In Congenital Heart Diseases: The Broken Heart, 203–21. Vienna: Springer Vienna, 2016. http://dx.doi.org/10.1007/978-3-7091-1883-2_15.

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Schmalor, Anita. "Epigenetics." In Encyclopedia of Personality and Individual Differences, 1401–3. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-24612-3_1464.

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Zhou, Li, Henry W. Lim, and Qing-Sheng Mi. "Epigenetics." In Vitiligo, 253–64. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-62960-5_25.

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Smith, Daniel. "Epigenetics." In Encyclopedia of Clinical Neuropsychology, 1316. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-57111-9_9029.

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Horsthemke, Bernhard. "Epigenetics." In Vogel and Motulsky's Human Genetics, 299–318. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-37654-5_11.

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Ellenbroek, Bart, Alfonso Abizaid, Shimon Amir, Martina de Zwaan, Sarah Parylak, Pietro Cottone, Eric P. Zorrilla, et al. "Epigenetics." In Encyclopedia of Psychopharmacology, 486–89. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_392.

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LaCaille, Lara, Anna Maria Patino-Fernandez, Jane Monaco, Ding Ding, C. Renn Upchurch Sweeney, Colin D. Butler, Colin L. Soskolne, et al. "Epigenetics." In Encyclopedia of Behavioral Medicine, 702–4. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1005-9_685.

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Dragun, Anthony E., Paul J. Schilling, Tod W. Speer, Feng-Ming Kong, Jingbo Wang, Hedvig Hricak, Oguz Akin, et al. "Epigenetics." In Encyclopedia of Radiation Oncology, 223. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-540-85516-3_312.

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Conference papers on the topic "Epigenetics"

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Faria, Gustavo Hugo de Souza. "The impact of epigenetics on the development of neurodegenerative diseases." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.654.

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Introduction: Neurodegenerative diseases affect thousands of people in Brazil and have been increasing in frequency with the aging population. However, little is known about the molecular mechanisms and biomarkers of these diseases, which leads to a medical approach based on symptomatic and unresolving characteristics. Epigenetics, including DNA methylation, histone modifications, and changes in regulatory RNAs, emerges as a tool for prevention of neurodegenerative diseases. Objectives: To review studies that discuss the role of epigenetics in the development of neurodegenerative diseases. Methodology: This study involved an integrative review of papers published from 2016 to 2021 by searching PubMed and Scopus. Results: The studies showed that there is evidence that epigenetic mechanisms interfere with the development of major neurodegenerative diseases. Huntington’s disease presents an altered gene from birth, but transcriptional dysregulation is characteristic of the pathology that may be correlated to the age of disease onset in the cortex. In Parkinson’s disease dysregulation of expression of a specific protein is believed to play a central role in the disease and occurs through aberrant methylation that controls activation or suppression. In relation to Alzheimer’s disease, it has been found that deregulated DNA methylation and demethylation is linked to the onset and progression of the disease. In addition, these epigenetic factors are interfered with by diet, aging, and exercise. Conclusions: Investment in epigenetic studies is needed to understand possible markers of neurodegenerative diseases, for early diagnosis and the formation of epidrugs with the ability to treat.
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Andrade, Gustavo Moreira, Antonio Márcio Teodoro Cordeiro Silva, Amanda Hasan Figueiredo, Ana Luiza Gomes Monteiro, Leonardo Chaves de Oliveira Moraes, and Giovanna Silva Quirino. "The use of epigenetics in the treatment of triplenegative breast cancer, focusing on IncRNA." In Brazilian Breast Cancer Symposium 2023. Mastology, 2023. http://dx.doi.org/10.29289/259453942023v33s1032.

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Objective: In triple-negative breast cancer (CMTN), the standard therapeutic procedure is usually not very effective due to the aggressiveness of the disease. Therefore, it is important to identify and characterize new forms of treatment for this neoplasm. In this context, the study of the genetic material of diseases has gained notoriety among alternative forms of therapy, as long non-coding RNAs (IncRNAs) have been identified in neoplastic cells. Therefore, the aim of this study was to evaluate the use of epigenetics in the treatment of CMTN, with emphasis on lncRNAs. Methodology: A systematic review of the specialized scientific literature was carried out, in the PubMed database, with the descriptors: “breast cancer,” “epigenetic,” and “treatment”; the Boolean operator: “AND”; and the filters: “free full text,” “adults: 19+ years,” and publication date from 2021 to 2023. A total of 32 articles were identified, with 3 included Results: Epigenetics influences the treatment of breast cancer; as the lncRNA was found in neoplastic cells, it was possible to monitor the prognosis of the disease. The lncRNA Uc003xsl.1 was associated with a poor prognosis, as it was related to advanced stages of CMTN, increasing the transcriptional activity of NFkB, which promotes tumor progression. On the contrary, the lncRNA LINC00472 proved to be a marker of good prognosis, as it inhibited the proliferation, invasion, and migration of neoplastic cells in the CMTN. Furthermore, with regard to breast cancer, lncRNA IGF-2AS proved to be an important biomarker, as it slows tumor growth in vivo, repressing malignancy and tumor progression. Therefore, IncRNAs have gained notoriety in treatment as regulators of breast cancer tumorigenesis. Conclusion: Thus, the use of epigenetics in the treatment of CMTN has proven to be essential to curbing neoplastic cells, as it interferes with tumor proliferation in different ways, either by influencing transcription or by slowing down growth.
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"1st Epigenetics Society International Meeting "Epigenetics of Disease and Development"." In 1st Epigenetics Society International Meeting "Epigenetics of Disease and Development". Frontiers Media SA, 2023. http://dx.doi.org/10.3389/978-2-8325-1235-7.

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VANYUSHIN, B. F. "EPIGENETICS AND EVOLUTION." In 5TH MOSCOW INTERNATIONAL CONFERENCE "MOLECULAR PHYLOGENETICSAND BIODIVERSITY BIOBANKING". TORUS PRESS, 2018. http://dx.doi.org/10.30826/molphy2018-11.

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Uno, Etsuko. "X inactivation and epigenetics." In ACM SIGGRAPH 2012 Computer Animation Festival. New York, New York, USA: ACM Press, 2012. http://dx.doi.org/10.1145/2341836.2341900.

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"Epigenetics behind SARS COV2." In Bioinformatics of Genome Regulation and Structure/Systems Biology (BGRS/SB-2022) :. Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, 2022. http://dx.doi.org/10.18699/sbb-2022-507.

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Marques, Flavia Araújo Marques, and Matheus Moreira. "EPIGENETICS IN COLORECTAL CANCER." In Congresso Online de Atualização em Oncologia. Congresse.me, 2023. http://dx.doi.org/10.54265/mobq8354.

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Sari, Lili Nur Indah, and Elza Ibrahim Auerkari. "Molecular Genetics and Epigenetics of Ankyloglossia." In 11th International Dentistry Scientific Meeting (IDSM 2017). Paris, France: Atlantis Press, 2018. http://dx.doi.org/10.2991/idsm-17.2018.14.

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Raj, Utkarsh, Saurav Kumar Mishra, Chakshu Bhatia, Pritish Kumar Varadwaj, and Gaurav Harit. "A Comprehensive Knowledgebase on Cancer Epigenetics." In 2018 International Conference on Bioinformatics and Systems Biology (BSB). IEEE, 2018. http://dx.doi.org/10.1109/bsb.2018.8770626.

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Utami, Wulan Sri, Ferry Pergamus Gultom, Harismanto, and Elza Ibrahim Auerkari. "Molecular genetics and epigenetics of ameloblastoma." In ADVANCES IN INTELLIGENT APPLICATIONS AND INNOVATIVE APPROACH. AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0140214.

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Reports on the topic "Epigenetics"

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Carmell, Michelle A., and Gregory J. Hannon. Whole Genome Epigenetics. Fort Belvoir, VA: Defense Technical Information Center, May 2005. http://dx.doi.org/10.21236/ada446925.

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Carmell, Michelle A., and Gregory J. Hannon. Whole Genome Epigenetics. Fort Belvoir, VA: Defense Technical Information Center, May 2003. http://dx.doi.org/10.21236/ada417880.

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Kemp, Christopher J. Transgenerational Radiation Epigenetics. Fort Belvoir, VA: Defense Technical Information Center, September 2012. http://dx.doi.org/10.21236/ada569020.

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Kemp, Christopher J. Transgenerational Radiation Epigenetics. Fort Belvoir, VA: Defense Technical Information Center, September 2013. http://dx.doi.org/10.21236/ada590505.

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Kemp, Christopher J. Transgenerational Radiation Epigenetics. Fort Belvoir, VA: Defense Technical Information Center, September 2011. http://dx.doi.org/10.21236/ada555958.

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Seale, Maria, Natàlia Garcia-Reyero, R. Salter, and Alicia Ruvinsky. An epigenetic modeling approach for adaptive prognostics of engineered systems. Engineer Research and Development Center (U.S.), July 2021. http://dx.doi.org/10.21079/11681/41282.

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Prognostics and health management (PHM) frameworks are widely used in engineered systems, such as manufacturing equipment, aircraft, and vehicles, to improve reliability, maintainability, and safety. Prognostic information for impending failures and remaining useful life is essential to inform decision-making by enabling cost versus risk estimates of maintenance actions. These estimates are generally provided by physics-based or data-driven models developed on historical information. Although current models provide some predictive capabilities, the ability to represent individualized dynamic factors that affect system health is limited. To address these shortcomings, we examine the biological phenomenon of epigenetics. Epigenetics provides insight into how environmental factors affect genetic expression in an organism, providing system health information that can be useful for predictions of future state. The means by which environmental factors influence epigenetic modifications leading to observable traits can be correlated to circumstances affecting system health. In this paper, we investigate the general parallels between the biological effects of epigenetic changes on cellular DNA to the influences leading to either system degradation and compromise, or improved system health. We also review a variety of epigenetic computational models and concepts, and present a general modeling framework to support adaptive system prognostics.
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Seale, Maria, R. Salter, Natàlia Garcia-Reyero,, and Alicia Ruvinsky. A fuzzy epigenetic model for representing degradation in engineered systems. Engineer Research and Development Center (U.S.), September 2022. http://dx.doi.org/10.21079/11681/45582.

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Degradation processes are implicated in a large number of system failures, and are crucial to understanding issues related to reliability and safety. Systems typically degrade in response to stressors, such as physical or chemical environmental conditions, which can vary widely for identical units that are deployed in different places or for different uses. This situational variance makes it difficult to develop accurate physics-based or data-driven models to assess and predict the system health status of individual components. To address this issue, we propose a fuzzy set model for representing degradation in engineered systems that is based on a bioinspired concept from the field of epigenetics. Epigenetics is concerned with the regulation of gene expression resulting from environmental or other factors, such as toxicants or diet. One of the most studied epigenetic processes is methylation, which involves the attachment of methyl groups to genomic regulatory regions. Methylation of specific genes has been implicated in numerous chronic diseases, so provides an excellent analog to system degradation. We present a fuzzy set model for characterizing system degradation as a methylation process based on a set-theoretic representation for epigenetic modeling of engineered systems. This model allows us to capture the individual dynamic relationships among a system, environmental factors, and state of health.
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Ruvinsky, Alicia, Maria Seale, R. Salter, and Natàlia Garcia-Reyero. An ontology for an epigenetics approach to prognostics and health management. Engineer Research and Development Center (U.S.), March 2023. http://dx.doi.org/10.21079/11681/46632.

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Techniques in prognostics and health management have advanced considerably in the last few decades, enabled by breakthroughs in computational methods and supporting technologies. These predictive models, whether data-driven or physics-based, target the modeling of a system’s aggregate performance. As such, they generalize assumptions about the modelled system’s components, and are thus limited in their ability to represent individual components and the dynamic environmental factors that affect composite system health. To address this deficiency, we have developed an epigenetics-inspired knowledge representation for engineered system state that encompasses components and environmental factors. Epigenetics is concerned with explaining how environmental factors affect the expression of an organism’s genetic material. The field has derived important in-sights into the development and progression of disease states based on how environmental factors impact genetic material, causing variations in how a gene is expressed. The health of an engineered system is similarly influenced by its environment. A foundation for a new approach to prognostics based on epigenetics must begin by representing the entities and relationships of an engineered system from the perspective of epigenetics. This paper presents an ontology for an epigenetics-inspired representation of an engineered system. An ontology describing the epigenetics of an engineered system will enable the composition of a formal model and the incremental development of a more robust, causal reasoning system.
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Repository, Science. Epigenetics – Blurring the Lines between Nature and Nurture. Science Repository OÜ, November 2020. http://dx.doi.org/10.31487/sr.blog.12.

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McCafferty, Dewey G. Targeting Epigenetics Therapy for Estrogen Receptor-Negative Breast Cancers. Fort Belvoir, VA: Defense Technical Information Center, October 2014. http://dx.doi.org/10.21236/ada613131.

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