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Dissertations / Theses on the topic 'Epidermis'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Fear, Mark William. "Wnt signalling in normal adult epidermis and epidermal tumours." Thesis, Queen Mary, University of London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406139.

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2

Akinduro, Olufolake A. E. "Autophagy in epidermis." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8703.

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Organ‐transplant recipients (OTRs) on a new class of immunosuppressants, rapamycin and its analogues, have reduced cutaneous Squamous Cell Carcinomas (cSCCs). Rapamycin, an mTORC1 inhibitor, is also a known autophagy inducer in experimental models. Autophagy, which literally means self‐eating, is a cell survival mechanism but can also lead to cell death. Therefore, the main hypothesis behind this work is that rapamycin prevents epidermal tumourigenesis by either affecting epidermal mTOR regulation of autophagy and/or selectively affecting epidermal AKT isoform activity. Epidermal keratinocytes

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3

O'Shaughnessy, Ryan Francis Lucas. "Analysis of gene expression in normal and neoplastic keratinocytes." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325883.

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4

Gdula, Michal R. "Establishing tissue-specific chromatin organization during development of the epidermis. Nuclear architecture of different layers of murine epidermis and the role of p63 and Satb1 in establishing tissue-specific organization of the epidermal differentiation complex locus." Thesis, University of Bradford, 2011. http://hdl.handle.net/10454/5382.

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During development, multipotent stem cells establish tissue-specific programmes of gene expression that underlie a process of differentiation into specialized cell types. It was shown in the study that changes in the nuclear architecture during terminal keratinocyte differentiation show correlation with the dynamics of the transcriptional and metabolic activity. In particular, terminal differentiation is accompanied by the decrease of nuclear volume, elongation of its shape, reduction of the number and fusion of nucleoli, increase in the number of centromeric clusters and a dramatic de

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5

Löwenau, Lilian Julia [Verfasser]. "Human epidermis reconstructed from UV-B irradiated keratinocytes mimics epidermal ageing / Lilian Julia Löwenau." Berlin : Freie Universität Berlin, 2016. http://d-nb.info/1121588123/34.

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6

Ledesma, Jenilyn A. "A stereological and AgNOR analysis of the epidermis and naevi of Chinese." Thesis, Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B18656547.

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7

Gdula, Michal Ryszard. "Establishing tissue-specific chromatin organization during development of the epidermis : nuclear architecture of different layers of murine epidermis and the role of p63 and Satb1 in establishing tissue-specific organization of the epidermal differentiation complex locus." Thesis, University of Bradford, 2011. http://hdl.handle.net/10454/5382.

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During development, multipotent stem cells establish tissue-specific programmes of gene expression that underlie a process of differentiation into specialized cell types. It was shown in the study that changes in the nuclear architecture during terminal keratinocyte differentiation show correlation with the dynamics of the transcriptional and metabolic activity. In particular, terminal differentiation is accompanied by the decrease of nuclear volume, elongation of its shape, reduction of the number and fusion of nucleoli, increase in the number of centromeric clusters and a dramatic decrease o

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8

Raj, N. "Mechanistic studies on the human epidermis." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1531697/.

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This thesis is an effort to study the concepts of skin barrier function in relation to skin physiology and biochemistry. The study focused on anatomical differences, effects of photoaging, the sensitivity of skin and pigmentation differences. The most photoexposed area of the skin is the face, so the study was designed to evaluate the factors responsible for barrier function in the facial stratum corneum. Firstly, stratum corneum (SC) protein estimated using a colorimetric assay was compared to the non-destructive Squamescan® method. The study found a good correlation between the two methods f

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9

Easty, David Julia. "A study of the biochemistry and immunochemistry of differentiation of the normal epidermis and involved psoriatic epidermis." Thesis, Imperial College London, 1988. http://hdl.handle.net/10044/1/47044.

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10

Harper, Erin Gail. "Adhesion to laminin 5 suppresses p38 map kinase and activating transcription factor 3 in leading keratinocytes of epidermal wounds /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/9299.

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11

Sadowski, Tomasz [Verfasser], Kai [Gutachter] Simons, and Michael [Gutachter] Meurer. "Das physiologische Lipidom menschlicher Epidermis : The physiological lipidome of human epidermis / Tomasz Sadowski ; Gutachter: Kai Simons, Michael Meurer." Dresden : Technische Universität Dresden, 2019. http://d-nb.info/1227196695/34.

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12

Sadowski, Tomasz [Verfasser], Kai Gutachter] Simons, and Michael [Gutachter] [Meurer. "Das physiologische Lipidom menschlicher Epidermis : The physiological lipidome of human epidermis / Tomasz Sadowski ; Gutachter: Kai Simons, Michael Meurer." Dresden : Technische Universität Dresden, 2019. http://d-nb.info/1227196695/34.

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13

Panzer, Rüdiger. "Hautbarrierestörung induziert TLR9-Expression in der Epidermis /." Kiel, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000254021.

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14

Gaisford, Wendy Caron. "Aspects of methicillin resistance in Staphylococcus epidermis." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302972.

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15

Gumbrys, Aurimas. "Epidermis and re-epithelialization in Schmidtea mediterranea." Thesis, Open University, 2017. http://oro.open.ac.uk/50972/.

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Epidermal layer is crucial for organism’s survival as its ability to close the wound is essential for tissue recovery. Planarian epidermis enables animal recovery and survival after virtually any body part amputation. Nevertheless, neither the epidermis nor the mechanisms endowing such a remarkable wound healing capacity is described in detail in planarians. Our work introduces live imaging methodology, which allows following epidermal cells and their response to tissue damage or tissue loss for extended time (hours) and in high resolution. Using our methods, we followed planarian cells live f

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16

Pavlish, John R. "Polymer substrates with microneedles for epidermis injection." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/58379.

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Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2009.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 31).<br>Injections of medicine into the body are commonplace, whether they be intravenous or capsules. The benefit of using a macroneedle for injecting cargo into the circulatory system is its simplicity. However, introduction of the needle intravenously can also include foreign matter if the needle is unsterile. Due to macroneedles ability to pierce skin and veins for effortless insertion, it can also damage

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17

Blackstock, N. "Factors affecting the structure of salmonid epidermis." Thesis, University of Stirling, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354053.

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18

Lössner, Isabel. "Die Rolle des bakteriellen Insertionselements IS256 bei der Modulation der Biofilmbildung in Staphylococcus epidermidis." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=966050983.

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19

Norlén, Lars Petter Oskar. "The skin barrier : structure and physical function /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3533-5/.

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20

Fairclough, Rebecca J. "Effect of Hailey-Hailey disease mutations on the function of a new variant of human secretory pathway CaÂ²âº/MnÂ²âº-ATPase (hSPCA1)." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275321.

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21

Chakrabarty, Kaushik H. "Development and evaluation of epidermal/dermal skin composites." Thesis, University of Sheffield, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273737.

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22

Jones, Keith Thomas. "The role of intracellular calcium in the control of keratinocyte differentiation." Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359170.

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23

Kettenbach, Arminja Nadine. "Molekulare Mechanismen in Zelldifferenzierung und Zellteilung." [S.l. : s.n.], 2006.

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24

Pfeiffer, Sven. "Wingless transport in the embryonic epidermis of drosophila." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248103.

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25

Silva-Vargas, Violeta. "Characterisation and modulation of patterning of mammalian epidermis." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1445848/.

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The epidermis is maintained by proliferation of stem cells and differentiation of their progeny. In my PhD thesis I have studied the mechanisms by which these processes are compartmentalised. P-catenin levels determine lineage commitment in the epidermis. I investigated the role of p-catenin in patterning of the epidermal stem cell compartment and its niche during de novo hair follicle formation. For this I used K14ANP-cateninER transgenic mice. I found that the levels of p-catenin activation determine the number and location of ectopic hair follicles, showing that follicle formation is a thre

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26

Pearton, David Jonathan. "Proprotein convertases in terminal differentiation of epidermis and processing of the profilaggrin amino terminus /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/9230.

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27

Sully, Katherine L. "Inhibition of mammalian target of rapamycin (mTOR) in epidermis." Thesis, Queen Mary, University of London, 2012. http://qmro.qmul.ac.uk/xmlui/handle/123456789/3360.

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Cutaneous squamous cell carcinoma (cSCC) is one of the most common Caucasian skin cancers and is particularly prevalent following chronic ultraviolet (UV) radiation exposure and in immunosuppressed patients. Recent use of rapamycin as an immunosuppressant significantly reduces SCC after organ transplantation. However the mechanism remains unclear. Rapamycin inhibits mammalian target of rapamycin (mTOR) kinase, downstream from phosphatidylinositol-3 kinase (PI3K) and Akt kinases previously implicated in SCC. The aim was to find the effects of rapamycin on PI3K-Akt-mTOR signalling in epidermis i

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28

Spencer, Mary-Jane. "The influence of ultraviolet B radiation on human epidermis." Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/20808.

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The aim of this work was to study the relationship between UVB and LC by examining the influence of moderate, suberythemal doses of UVB, such as are used to treat psoriasis, on epidermal LC morphology, numbers and surface expression of CD1a and major histocompatibility class II (MHC II) antigens in human skin. A six week course of UVB irradiation, using our standard therapeutic regimen for the treatment of psoriasis (total doses of UVB ranged from 2.58-5.58 J/cm<SUP>2</SUP>), was administered to nine healthy subjects. The morphology and number of LCs, and the distribution and expression of cer

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29

Enikanolaiye, Adebola. "The Role of the Claudin 6 Cytoplasmic Tail In Epidermal Differentiation and the Role of Cdx In Endodermal Development." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32354.

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The mammalian skin provides a necessary barrier between the organism and the environment, defending against loss of water and solutes, preventing the invasion of pathogens as well as protecting against chemical and physical assault. Claudin (Cldn)-based Tight Junctions (TJs) are the main functional part of the skin barrier. In particular, Cldn6 through its cytoplasmic tail has been shown to be important for barrier function. In other to further investigate the role of the Cldn6 tail in TJ-function, we developed Cldn6 mouse mutants carrying varying truncations of the Cldn6 tail. Both of these m

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30

Souto, Luis Ricardo Martinhão. "Modelo de pele humana (derme + epiderme) reconstruida in vitro." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313309.

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Orientador: Maria Beatriz Puzzi, Maria Helena Stangler Kraemer<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-04T03:54:34Z (GMT). No. of bitstreams: 1 Souto_LuisRicardoMartinhao_M.pdf: 2402921 bytes, checksum: a79b6ae181ce1b24d01ec608815d8bf7 (MD5) Previous issue date: 2005<br>Resumo: A obtenção de uma pele humana que apresente derme e epiderme, reconstruída a partir de células isoladas de pacientes, possibilita a realização de enxertos autólogos de pele reconstruída em laboratório (in vitro) em pacientes co

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31

Koster, Jan Johannes Bernardus. "Plakin interactions in the hemidesmosome." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/69999.

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32

Boudonck, Kurt. "Dynamic organization of transcription and transcript processing components in plants." Thesis, University of East Anglia, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302341.

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33

Carpenter, Kevin Joseph. "Structure and evolution of the leaf epidermis in basal angiosperms /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2005. http://uclibs.org/PID/11984.

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34

Welss, Thomas. "Molekularbiologische Untersuchungen differenziell exprimierter Gene in Tumoren der humanen Epidermis." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965458849.

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35

Panchal, Heena. "Neuregulin3 alters cell fate in the epidermis and mammary gland." Thesis, Institute of Cancer Research (University Of London), 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498460.

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36

Hwang, Hwei-tein. "Characterisation of cDNA clones for mRNAs expressed in leaf epidermis." Thesis, University of Nottingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289432.

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37

Lowell, Sally Elizabeth. "Delta and the fate of stem cells in human epidermis." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402134.

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38

Nuttall, A. "The role of the epidermis in pathogenesis of systemic sclerosis." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/19394/.

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Studies into the pathogenesis of systemic sclerosis (SSc) skin fibrosis to date have concentrated on dermal changes in the disease. Little attention has been paid to the epidermis in SSc. Epithelial-fibroblast interactions are believed to regulate wound healing and contribute to a number of fibrotic diseases. Recent proteomic data from our laboratory reveals altered keratinocyte (KC) specific proteins in SSc skin consistent with a wound healing phenotype of the disease epidermis. I therefore studied SSc KCs focusing on differentiation and KC-fibroblast interaction. I found that KC maturation i

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39

Wang, Sha. "The Apicobasal Polarity Protein Network during Stratified Xenopus Epidermis Development." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1397736009.

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40

Pyee, Jaeho. "Isolation and characterization of plant epidermis-specific proteins and genes /." The Ohio State University, 1994. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487853913103024.

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41

Gallagher, Kimberly L. "Analysis of asymmetric cell divisions in the maize leaf epidermis /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2000. http://wwwlib.umi.com/cr/ucsd/fullcit?p3007134.

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42

Terzi, Rodríguez Denise Andrea. "Caracterización Anatómica de la Epidermis Foliar en Sequoia sempervirens (D. Don)." Tesis, Universidad de Chile, 2008. http://repositorio.uchile.cl/handle/2250/105013.

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43

Vorstenbosch, Joshua. "Overexpression of CD109 in the epidermis reduces skin fibrosis and inflammation." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116840.

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Transforming growth factor-beta (TGF-ß) is a multifunctional growth factor involved in a variety of cellular processes including wound healing, extracellular matrix deposition, inflammation, and fibrosis. Excessive TGF-ß signaling during wound healing causes sustained inflammation and elevated expression of extracellular matrix proteins, which have both been associated with fibrosis and scarring. Therefore, inhibition of TGF-ß during wound healing is an attractive target to reduce fibrotic skin disorders. Our lab is interested in CD109, a 150 kDa GPI-anchored protein which has been shown to b

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44

Courtney, Alan Peter. "The role of innexins in the embryonic epidermis of Drosophila melanogaster." Thesis, University of Sussex, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413334.

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45

FREZZA, VALENTINA. "Role of TG3 in the protection of epidermis from UVB photodamage." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2015. http://hdl.handle.net/2108/202954.

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La transglutaminasi 3 è una proteina solubile che appartiene a un’importante famiglia di enzimi dipendenti dal Ca2+, che catalizzano diversi tipi di modificazioni post-traduzionali. La più studiata e nota reazione catalizzate dalle transglutaminasi è il legame crociato tra proteine. La generazione di legami covalenti ε(γ-glutamil)lisina tra polipeptidi adiacenti oppure intracatena, permette la stabilizzazione di complessi proteici durante vari processi cellulari. La famiglia delle transglutaminasi include nove membri, di cui tre (TG1, TG3 e TG5) sono espressi nella pelle durante il differenzia

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46

Wood, Julian Lawrence. "The role of pH signalling in stomatal responses." Thesis, University of Oxford, 1996. https://ora.ox.ac.uk/objects/uuid:e97ed751-5a06-4bc7-9a48-d09b8a93d9a8.

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The role of cytoplasmic pH in guard cell signal transduction was investigated in epidermal strips of Commelina communis. The cytoplasmic pH of guard cells was measured by dual excitation ratio confocal laser scanning microscopy. Large transient alkalinisations occurred for up to 20 minutes both during closure, in response to ABA and calcium, and opening in response to IAA and fusicoccin. Therefore the direction of the pH change does not determine the direction stomatal movement in Commelina communis in contrast to previous reports in Paphiopedilum tonsum. Furthermore, CO<sub>2</sub> caused a s

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47

Owen, Markus Roger. "Mathematical modelling of the macrophage invasion of tumours and juxtacrine signalling in epidermal wound healing." Thesis, University of Warwick, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.344031.

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48

Larivière, Nathalie. "Integral Roles for the Tight Junction Protein Claudin-6 in Regulating Epidermal Homeostasis." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/30650.

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Forming and maintaining an intact epidermal permeability barrier (EPB) is necessary to mammalian health and dysregulation of this process can result in serious complications. Tight junctions (TJs) and their integral proteins the Claudins (Cldns) have both structural and signaling importance to the skin barrier and the latter is most likely mediated via Cldn tail interaction with cytoplasmic proteins. Given that the family member Cldn6 is known to be important to EPB function, we set out to determine the contribution of its cytoplasmic tail domain to TJ-mediated homoeostasis. Using transgenic

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49

Tan, Wei Min. "Single cell gene expression profiling of human epidermal keratinocytes." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609685.

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50

Lübbe, Katharina. "Entwicklung und Einsatz eines In-vitro-Ischämiemodels zur Untersuchung zellulärer Pathomechanismen der Klauenrehe des Rindes." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-171594.

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Die subklinische Klauenrehe oder claw horn disruption (CHD) ist von großer wirtschaftlicher Bedeutung für die Rinderhaltung, da sie zu Lahmheiten, Beeinträchtigungen des Allgemeinbefindens sowie einer eingeschränkten Leistungsfähigkeit der Tiere führt. Trotz zahlreicher Untersuchungen sind die pathophysiologischen Grundlagen der CHD noch immer nicht vollständig geklärt. Die derzeitigen Hypothesen weisen auf eine Ischämie in den noch lebensfähigen Epidermisschichten infolge einer veränderten dermalen Mikrozirkulation. Diese hat pathophysiologische Veränderungen zur Folge, die eine Störung der e

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