Journal articles: 'Enzymatic functionalization'

1

Lewis, Jared C., Pedro S. Coelho, and Frances H. Arnold. "Enzymatic functionalization of carbon–hydrogen bonds." Chem. Soc. Rev. 40, no. 4 (2011): 2003–21. http://dx.doi.org/10.1039/c0cs00067a.

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Acero, Enrique Herrero, Caroline Gamerith, Andreas Ortner, Doris Ribitsch, Georg Steinkellner, Karl Gruber, Helmut Schwab, and Georg M. Guebitz. "Strategies for enzymatic functionalization of synthetic polymers." New Biotechnology 31 (July 2014): S31. http://dx.doi.org/10.1016/j.nbt.2014.05.1684.

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Herrera-González, Azucena, Gema Núñez-López, Sandrine Morel, Lorena Amaya-Delgado, Georgina Sandoval, Anne Gschaedler, Magali Remaud-Simeon, and Javier Arrizon. "Functionalization of natural compounds by enzymatic fructosylation." Applied Microbiology and Biotechnology 101, no. 13 (June 8, 2017): 5223–34. http://dx.doi.org/10.1007/s00253-017-8359-5.

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Faccio, G., S. Senkalla, L. Thöny-Meyer, and M. Richter. "Enzymatic multi-functionalization of microparticles under aqueous neutral conditions." RSC Advances 5, no. 29 (2015): 22319–25. http://dx.doi.org/10.1039/c5ra00669d.

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Kaur, Amandeep, J. N. Chakraborty, and Kashyap Kumar Dubey. "Enzymatic Functionalization of Wool for Felting Shrink-Resistance." Journal of Natural Fibers 13, no. 4 (July 3, 2016): 437–50. http://dx.doi.org/10.1080/15440478.2015.1043686.

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Zhang, Lei, Wenshan Zhao, Hengzhen Chen, and Yuanchen Cui. "Enzymatic synthesis of phenol polymer and its functionalization." Journal of Molecular Catalysis B: Enzymatic 87 (March 2013): 30–36. http://dx.doi.org/10.1016/j.molcatb.2012.10.015.

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Lewis, Jared C., Pedro S. Coelho, and Frances H. Arnold. "ChemInform Abstract: Enzymatic Functionalization of Carbon-Hydrogen Bonds." ChemInform 42, no. 29 (June 27, 2011): no. http://dx.doi.org/10.1002/chin.201129261.

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Ahmadi, Yasaman, Elisa De Llano, and Ivan Barišić. "(Poly)cation-induced protection of conventional and wireframe DNA origami nanostructures." Nanoscale 10, no. 16 (2018): 7494–504. http://dx.doi.org/10.1039/c7nr09461b.

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9

Guzmán-Mendoza, José Jesús, David Chávez-Flores, Silvia Lorena Montes-Fonseca, Carmen González-Horta, Erasmo Orrantia-Borunda, and Blanca Sánchez-Ramírez. "A Novel Method for Carbon Nanotube Functionalization Using Immobilized Candida antarctica Lipase." Nanomaterials 12, no. 9 (April 26, 2022): 1465. http://dx.doi.org/10.3390/nano12091465.

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Carbon nanotubes (CNTs) have been proposed as nanovehicles for drug or antigen delivery since they can be functionalized with different biomolecules. For this purpose, different types of molecules have been chemically bonded to CNTs; however, this method has low efficiency and generates solvent waste. Candida antarctica lipase is an enzyme that, in an organic solvent, can bind a carboxylic to a hydroxyl group by esterase activity. The objective of this work was to functionalize purified CNTs with insulin as a protein model using an immobilized lipase of Candida antarctica to develop a sustainable functionalization method with high protein attachment. The functionalized CNTs were characterized by scanning electron microscope (SEM), Raman spectroscopy, Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS–PAGE). The enzymatic functionalization of insulin on the surface of the CNTs was found to have an efficiency of 21%, which is higher in conversion and greener than previously reported by the diimide-activated amidation method. These results suggest that enzymatic esterification is a convenient and efficient method for CNT functionalization with proteins. Moreover, this functionalization method can be used to enhance the cellular-specific release of proteins by lysosomal esterases.

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Guzmán-Mendoza, José Jesús, David Chávez-Flores, Silvia Lorena Montes-Fonseca, Carmen González-Horta, Erasmo Orrantia-Borunda, and Blanca Sánchez-Ramírez. "A Novel Method for Carbon Nanotube Functionalization Using Immobilized Candida antarctica Lipase." Nanomaterials 12, no. 9 (April 26, 2022): 1465. http://dx.doi.org/10.3390/nano12091465.

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Carbon nanotubes (CNTs) have been proposed as nanovehicles for drug or antigen delivery since they can be functionalized with different biomolecules. For this purpose, different types of molecules have been chemically bonded to CNTs; however, this method has low efficiency and generates solvent waste. Candida antarctica lipase is an enzyme that, in an organic solvent, can bind a carboxylic to a hydroxyl group by esterase activity. The objective of this work was to functionalize purified CNTs with insulin as a protein model using an immobilized lipase of Candida antarctica to develop a sustainable functionalization method with high protein attachment. The functionalized CNTs were characterized by scanning electron microscope (SEM), Raman spectroscopy, Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS–PAGE). The enzymatic functionalization of insulin on the surface of the CNTs was found to have an efficiency of 21%, which is higher in conversion and greener than previously reported by the diimide-activated amidation method. These results suggest that enzymatic esterification is a convenient and efficient method for CNT functionalization with proteins. Moreover, this functionalization method can be used to enhance the cellular-specific release of proteins by lysosomal esterases.

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Dudkaitė, Vygailė, and Gintautas Bagdžiūnas. "Functionalization of Glucose Oxidase in Organic Solvent: Towards Direct Electrical Communication across Enzyme-Electrode Interface." Biosensors 12, no. 5 (May 13, 2022): 335. http://dx.doi.org/10.3390/bios12050335.

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Enzymatic biosensors based on glucose oxidase has been proven to be one of the effective strategies for the detection of glucose and contributed to health improvements. Therefore, research and debates to date are ongoing in an attempt to find the most effective way to detect this analyte using this enzyme as the recognition center. The 3rd generation biosensors using direct electron transfer (DET) type enzymes are a great way towards practical devices. In this work, we developed a simple method for the functionalization of glucose oxidase with redoxable ferrocene groups in chloroform. The enzyme retained its activity after storage in this organic solvent and after the functionalization procedures. This enzyme functionalization strategy was employed to develop the biosensing monolayer-based platforms for the detection of glucose utilizing the quasi-DET mechanism. As a result of an electrochemical regeneration of the catalytic center, the formation of harmful H2O2 is minimized during enzymatic electrocatalysis.

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Empel, Claire, Sripati Jana, and Rene M. Koenigs. "C-H Functionalization via Iron-Catalyzed Carbene-Transfer Reactions." Molecules 25, no. 4 (February 17, 2020): 880. http://dx.doi.org/10.3390/molecules25040880.

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The direct C-H functionalization reaction is one of the most efficient strategies by which to introduce new functional groups into small organic molecules. Over time, iron complexes have emerged as versatile catalysts for carbine-transfer reactions with diazoalkanes under mild and sustainable reaction conditions. In this review, we discuss the advances that have been made using iron catalysts to perform C-H functionalization reactions with diazoalkanes. We give an overview of early examples employing stoichiometric iron carbene complexes and continue with recent advances in the C-H functionalization of C(sp2)-H and C(sp3)-H bonds, concluding with the latest developments in enzymatic C-H functionalization reactions using iron-heme-containing enzymes.

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13

Ortner, A., A. Pellis, C. Gamerith, A. Orcal Yebra, D. Scaini, I. Kaluzna, D. Mink, S. de Wildeman, E. Herrero Acero, and G. M. Guebitz. "Superhydrophobic functionalization of cutinase activated poly(lactic acid) surfaces." Green Chemistry 19, no. 3 (2017): 816–22. http://dx.doi.org/10.1039/c6gc03150a.

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14

Crasson, O., N. Rhazi, O. Jacquin, A. Freichels, C. Jérôme, N. Ruth, M. Galleni, P. Filée, and M. Vandevenne. "Enzymatic functionalization of a nanobody using protein insertion technology." Protein Engineering Design and Selection 28, no. 10 (April 6, 2015): 451–60. http://dx.doi.org/10.1093/protein/gzv020.

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15

Ogończyk, D., P. Jankowski, and P. Garstecki. "Functionalization of polycarbonate with proteins; open-tubular enzymatic microreactors." Lab on a Chip 12, no. 15 (2012): 2743. http://dx.doi.org/10.1039/c2lc40204a.

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16

Yoshida, Toyokazu, and Toru Nagasawa. "Enzymatic functionalization of aromatic N-heterocycles: Hydroxylation and carboxylation." Journal of Bioscience and Bioengineering 89, no. 2 (January 2000): 111–18. http://dx.doi.org/10.1016/s1389-1723(00)88723-x.

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17

Munk, L., A. M. Punt, M. A. Kabel, and A. S. Meyer. "Laccase catalyzed grafting of –N–OH type mediators to lignin via radical–radical coupling." RSC Advances 7, no. 6 (2017): 3358–68. http://dx.doi.org/10.1039/c6ra26106j.

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Lignin can be functionalized with –N–OH type mediators via laccase catalysis. Three radical coupling mechanisms are suggested for this enzymatic “hetero-functionalization” which may be a new route for biomass lignin upgrading.

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18

Savin, Rémy, Nour-Ouda Benzaamia, Christian Njel, Sergey Pronkin, Christian Blanck, Marc Schmutz, and Fouzia Boulmedais. "Nanohybrid biosensor based on mussel-inspired electro-cross-linking of tannic acid capped gold nanoparticles and enzymes." Materials Advances 3, no. 4 (2022): 2222–33. http://dx.doi.org/10.1039/d1ma01193f.

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The mussel-inspired electro-cross-linking process allows the specific functionalization of a single electrode out of a microelectrode array by a highly sensitive nanohybrid enzymatic biosensor, using a cheap and abundant natural molecule.

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19

Kim, Min Jung, Guk Hwan An, and Yong Ho Choa. "Functionalization of Magnetite Nanoparticles for Protein Immobilization." Solid State Phenomena 124-126 (June 2007): 895–98. http://dx.doi.org/10.4028/www.scientific.net/ssp.124-126.895.

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The surface of magnetite nanoparticles which have been prepared by coprecipitation method was modified by carboxylic acid group of poly(3-thiophenacetic acid (3TA)). Then the egg white lysozyme was immobilized on the carboxylic acid group of the modification of the magnetite nanoparticles. Lysozyme immobilizing efficiency increased with increasing concentration of 3TA. And the functionalized magnetite particles had higher enzymatic capacity than non-functionalized magnetite nanoparticles.

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20

Karim, Zoheb, Sadaf Afrin, Qayyum Husain, and Rehan Danish. "Necessity of enzymatic hydrolysis for production and functionalization of nanocelluloses." Critical Reviews in Biotechnology 37, no. 3 (April 6, 2016): 355–70. http://dx.doi.org/10.3109/07388551.2016.1163322.

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21

Maleki, Mahin, Mohsen Adeli, Ali Kakanejadifard, Soodabeh Movahedi, and Farhad Bani. "Enzymatic functionalization of nanomaterials: A strategy for engineering their surfaces." Polymer 54, no. 18 (August 2013): 4802–6. http://dx.doi.org/10.1016/j.polymer.2013.07.023.

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22

Wang, Ping, Ying Zhou, Li Cui, Jiugang Yuan, Qiang Wang, Xuerong Fan, and Yajing Ding. "Enzymatic grafting of lactoferrin onto silk fibroins for antibacterial functionalization." Fibers and Polymers 15, no. 10 (October 2014): 2045–50. http://dx.doi.org/10.1007/s12221-014-2045-3.

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23

Jmel, Mohamed Amine, Ghazi Ben Messaoud, M. Nejib Marzouki, Mohamed Mathlouthi, and Issam Smaali. "Physico-chemical characterization and enzymatic functionalization of Enteromorpha sp. cellulose." Carbohydrate Polymers 135 (January 2016): 274–79. http://dx.doi.org/10.1016/j.carbpol.2015.08.048.

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24

Zhu, Tong, Lu Song, Ruifeng Li, and Bian Wu. "Enzymatic clickable functionalization of peptides via computationally engineered peptide amidase." Chinese Chemical Letters 29, no. 7 (July 2018): 1116–18. http://dx.doi.org/10.1016/j.cclet.2018.03.033.

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Agger, Jane W., and Birgitte Zeuner. "Bio-based surfactants: enzymatic functionalization and production from renewable resources." Current Opinion in Biotechnology 78 (December 2022): 102842. http://dx.doi.org/10.1016/j.copbio.2022.102842.

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26

Schumacher, Dominik, Oliver Lemke, Jonas Helma, Lena Gerszonowicz, Verena Waller, Tina Stoschek, Patrick M. Durkin, et al. "Broad substrate tolerance of tubulin tyrosine ligase enables one-step site-specific enzymatic protein labeling." Chemical Science 8, no. 5 (2017): 3471–78. http://dx.doi.org/10.1039/c7sc00574a.

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27

Pavelyev, Roman S., Rusalia M. Vafina, Konstantin V. Balakin, Oleg I. Gnezdilov, Aleksey B. Dobrynin, Olga A. Lodochnikova, Rashid Z. Musin, Galina A. Chmutova, Svetlana A. Lisovskaya, and Liliya E. Nikitina. "Synthesis and Antifungal Activity of β-Hydroxysulfides of 1,3-Dioxepane Series." Journal of Chemistry 2018 (October 10, 2018): 1–14. http://dx.doi.org/10.1155/2018/3589342.

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Synthesis of β-hydroxysulfides of 1,3-dioxepane series and their further functionalization were performed. Chiral β-hydroxysulfides were separated into enantiomers using enzymatic acylation by lipase PS. Study of antifungal activity of the obtained compounds showed that some enantiomerically pure 6-arylthio-1,3-dioxepan-5-ols represent promising antifungal drug candidates.

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Čorak, Ivana, Anita Tarbuk, Sandra Flinčec Grgac, and Tihana Dekanić. "Bio-Innovative Modification of Poly(Ethylene Terephthalate) Fabric Using Enzymes and Chitosan." Polymers 16, no. 17 (September 7, 2024): 2532. http://dx.doi.org/10.3390/polym16172532.

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This article investigates the activation of surface groups of poly(ethylene terephthalate) (PET) fibers in woven fabric by hydrolysis and their functionalization with chitosan. Two types of hydrolysis were performed—alkaline and enzymatic. The alkaline hydrolysis was performed in a more sustainable process at reduced temperature and time (80 °C, 10 min) with the addition of the cationic surfactant hexadecyltrimethylammonium chloride as an accelerator. The enzymatic hydrolysis was performed using Amano Lipase A from Aspergillus niger (2 g/L enzyme, 60 °C, 60 min, pH 9). The surface of the PET fabric was functionalized with the homogenized gel of biopolymer chitosan using a pad–dry–cure process. The durability of functionalization was tested after the first and tenth washing cycle of a modified industrial washing process according to ISO 15797:2017, in which the temperature was lowered from 75 °C to 50 °C, and ε-(phthalimido) peroxyhexanoic acid (PAP) was used as an environmentally friendly agent for chemical bleaching and disinfection. The influence of the above treatments was analyzed by weight loss, tensile properties, horizontal wicking, the FTIR-ATR technique, zeta potential measurement and SEM micrographs. The results indicate better hydrophilicity and effectiveness of both types of hydrolysis, but enzymatic hydrolysis is more environmentally friendly and favorable. In addition, alkaline hydrolysis led to a 20% reduction in tensile properties, while the action of the enzyme resulted in a change of only 2%. The presence of chitosan on polyester fibers after repeated washing was confirmed on both fabrics by zeta potential and SEM micrographs. However, functionalization with chitosan on the enzymatically bioactivated surface showed better durability after 10 washing cycles than the alkaline-hydrolyzed one. The antibacterial activity of such a bio-innovative modified PET fabric is kept after the first and tenth washing cycles. In addition, applied processes can be easily introduced to any textile factory.

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Zhu, Jieyi, Meiyan Feng, and Guofu Lian. "Graphene Based FET Biosensor for Organic-Phosphorous Sample Detection and the Enzymatic Analysis." Crystals 12, no. 10 (September 20, 2022): 1327. http://dx.doi.org/10.3390/cryst12101327.

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Our paper presents a flexible enzymatic acetylcholinesterase graphene based FET biosensor of the target organic phosphorous. The sensor’s purpose is to detect pesticide residues in the field of food safety. In our sensor design, the material is graphene with its functionalization, and graphene based FET structure will be discussed in one section of this paper. The mechanism of this graphene sensor is the enzymatic linked reaction on a sensor surface. The enzyme is fixed on the sensor surface by the linker 3-mercapto propionic acid. Measurement experiments using the biosensor were performed for detecting the concentration of isocarbophos (an organophosphate). The enzymatic biosensor has successfully detected 100 μg/mL isocarbophos from the water sample, presenting a significant detection limit index for organophosphate detection.

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Saleem-Batcha, Raspudin, Frederick Stull, Jacob N. Sanders, Bradley S. Moore, Bruce A. Palfey, K. N. Houk, and Robin Teufel. "Enzymatic control of dioxygen binding and functionalization of the flavin cofactor." Proceedings of the National Academy of Sciences 115, no. 19 (April 23, 2018): 4909–14. http://dx.doi.org/10.1073/pnas.1801189115.

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The reactions of enzymes and cofactors with gaseous molecules such as dioxygen (O2) are challenging to study and remain among the most contentious subjects in biochemistry. To date, it is largely enigmatic how enzymes control and fine-tune their reactions with O2, as exemplified by the ubiquitous flavin-dependent enzymes that commonly facilitate redox chemistry such as the oxygenation of organic substrates. Here we employ O2-pressurized X-ray crystallography and quantum mechanical calculations to reveal how the precise positioning of O2 within a flavoenzyme’s active site enables the regiospecific formation of a covalent flavin–oxygen adduct and oxygenating species (i.e., the flavin-N5-oxide) by mimicking a critical transition state. This study unambiguously demonstrates how enzymes may control the O2 functionalization of an organic cofactor as prerequisite for oxidative catalysis. Our work thus illustrates how O2 reactivity can be harnessed in an enzymatic environment and provides crucial knowledge for future rational design of O2-reactive enzymes.

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31

Francesko, Antonio, Lucas Blandón, Mario Vázquez, Petya Petkova, Jordi Morató, Annett Pfeifer, Thomas Heinze, Ernest Mendoza, and Tzanko Tzanov. "Enzymatic Functionalization of Cork Surface with Antimicrobial Hybrid Biopolymer/Silver Nanoparticles." ACS Applied Materials & Interfaces 7, no. 18 (April 29, 2015): 9792–99. http://dx.doi.org/10.1021/acsami.5b01670.

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32

Saleem Batcha, Raspudin, and Robin Teufel. "Enzymatic control of O2 reactivity and functionalization of the flavin cofactor." Acta Crystallographica Section A Foundations and Advances 75, a2 (August 18, 2019): e127-e127. http://dx.doi.org/10.1107/s2053273319094294.

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33

Leung, Melissa K. M., Christoph E. Hagemeyer, Angus P. R. Johnston, Catalina Gonzales, Marloes M. J. Kamphuis, Katie Ardipradja, Georgina K. Such, Karlheinz Peter, and Frank Caruso. "Bio-Click Chemistry: Enzymatic Functionalization of PEGylated Capsules for Targeting Applications." Angewandte Chemie 124, no. 29 (June 28, 2012): 7244–48. http://dx.doi.org/10.1002/ange.201203612.

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34

Leung, Melissa K. M., Christoph E. Hagemeyer, Angus P. R. Johnston, Catalina Gonzales, Marloes M. J. Kamphuis, Katie Ardipradja, Georgina K. Such, Karlheinz Peter, and Frank Caruso. "Bio-Click Chemistry: Enzymatic Functionalization of PEGylated Capsules for Targeting Applications." Angewandte Chemie International Edition 51, no. 29 (June 28, 2012): 7132–36. http://dx.doi.org/10.1002/anie.201203612.

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35

Yoshida, Toyokazu, and Toru Nagasawa. "ChemInform Abstract: Enzymatic Functionalization of Aromatic N-Heterocycles: Hydroxylation and Carboxylation." ChemInform 31, no. 35 (June 3, 2010): no. http://dx.doi.org/10.1002/chin.200035262.

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36

Liu, Qun, Jin Chai, Gongrui Guo, Sean McSweeney, and John Shanklin. "Structural basis for enzymatic terminal C—H bond functionalization of alkanes." Acta Crystallographica Section A Foundations and Advances 79, a1 (July 7, 2023): a63. http://dx.doi.org/10.1107/s2053273323099369.

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37

Reuillard, Bertrand, Solène Gentil, Marie Carrière, Alan Le Goff, and Serge Cosnier. "Biomimetic versus enzymatic high-potential electrocatalytic reduction of hydrogen peroxide on a functionalized carbon nanotube electrode." Chemical Science 6, no. 9 (2015): 5139–43. http://dx.doi.org/10.1039/c5sc01473e.

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38

Di Lauro, Michele, Gabriella Buscemi, Michele Bianchi, Anna De Salvo, Marcello Berto, Stefano Carli, Gianluca Maria Farinola, Luciano Fadiga, Fabio Biscarini, and Massimo Trotta. "Photovoltage generation in enzymatic bio-hybrid architectures." MRS Advances 5, no. 18-19 (2020): 985–90. http://dx.doi.org/10.1557/adv.2019.491.

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AbstractMost of the photochemical activity of bacterial photosynthetic apparatuses occurs in the reaction center, a transmembrane protein complex which converts photons into charge-separated states across the membrane with a quantum yield close to unity, fuelling the metabolism of the organism. Integrating the reaction center from the bacterium Rhodobacter sphaeroides onto electroactive surfaces, it is possible to technologically exploit the efficiency of this natural machinery to generate a photovoltage upon Near Infra-Red illumination, which can be used in electronic architectures working in the electrolytic environment such as electrolyte-gated organic transistors and bio-photonic power cells. Here, photovoltage generation in reaction center-based bio-hybrid architectures is investigated by means of chronopotentiometry, isolating the contribution of the functionalisation layers and defining novel surface functionalization strategies for photovoltage tuning.

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Bisker, Gili. "(Invited) Single-Walled Carbon Nanotube Functionalization Strategies for Monitoring Enzymatic Activity and Inhibition." ECS Meeting Abstracts MA2024-01, no. 8 (August 9, 2024): 847. http://dx.doi.org/10.1149/ma2024-018847mtgabs.

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Semiconducting single-walled carbon nanotubes (SWCNTs) fluoresce in the near-infrared range, which overlaps with the transparency window of biological samples, and they do not photobleach or blink. Moreover, they benefit from biocompatibility and the large surface area available for functionalization. Using tailored surface functionalization, SWCNTs can be rendered optical nanosensors, such that surface binding events or changes in the local proximity of the nanotubes translate to a modulation of the emitted fluorescence. This approach was successfully used to demonstrate the detection of small molecules, volatiles, bacteria, microRNA, proteins, metals, self-assembly processes, and active processes in vivo. We will discuss different strategies for monitoring enzymatic activity and inhibition using SWCNT-based sensors, including the incorporation of the enzyme’s target bond within a synthetic molecular complex used for suspending the SWCNTs, or by the detection of the product of the enzyme hydrolytic activity. We will also highlight recent applications of these techniques in clinically relevant samples. These findings not only showcase the potential of near-infrared fluorescent SWCNT in tracking enzymatic activity but also underscore their promising role in advancing biomedical research and applications.

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40

Pellis, Alessandro, Polly Ann Hanson, James W. Comerford, James H. Clark, and Thomas J. Farmer. "Enzymatic synthesis of unsaturated polyesters: functionalization and reversibility of the aza-Michael addition of pendants." Polymer Chemistry 10, no. 7 (2019): 843–51. http://dx.doi.org/10.1039/c8py01655k.

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41

Stein, Frank, Tahir Mehmood, Tilman Plass, Javid H. Zaidi, and Ulf Diederichsen. "Synthesis of trifunctional cyclo-β-tripeptide templates." Beilstein Journal of Organic Chemistry 8 (September 19, 2012): 1576–83. http://dx.doi.org/10.3762/bjoc.8.180.

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The concept of template-assembled synthetic proteins (TASP) describes a central scaffold that predefines the three dimensional structure for diverse molecules linked to this platform. Cyclic β-tripeptides are interesting candidates for use as templates due to their conformationally defined structure, stability to enzymatic degradation, and ability to form intermolecular stacked tubular structures. To validate the applicability of cyclic β-tripeptides within the TASP concept, an efficient synthesis of the cyclopeptide with orthogonal functionalization of the side chains is desired. A solid-phase-supported route with on-resin cyclization is described, employing the aryl hydrazide linker cleavable by oxidation. An orthogonal protection-group strategy allows functionalization of the central cyclic β-tripeptide with up to three different peptide fragments or fluorescent labels.

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42

Lobiuc, Andrei, Naomi-Eunicia Pavăl, Ionel I. Mangalagiu, Roxana Gheorghiță, Gabriel-Ciprian Teliban, Dorina Amăriucăi-Mantu, and Vasile Stoleru. "Future Antimicrobials: Natural and Functionalized Phenolics." Molecules 28, no. 3 (January 22, 2023): 1114. http://dx.doi.org/10.3390/molecules28031114.

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With incidence of antimicrobial resistance rising globally, there is a continuous need for development of new antimicrobial molecules. Phenolic compounds having a versatile scaffold that allows for a broad range of chemical additions; they also exhibit potent antimicrobial activities which can be enhanced significantly through functionalization. Synthetic routes such as esterification, phosphorylation, hydroxylation or enzymatic conjugation may increase the antimicrobial activity of compounds and reduce minimal concentrations needed. With potent action mechanisms interfering with bacterial cell wall synthesis, DNA replication or enzyme production, phenolics can target multiple sites in bacteria, leading to a much higher sensitivity of cells towards these natural compounds. The current review summarizes some of the most important knowledge on functionalization of natural phenolic compounds and the effects on their antimicrobial activity.

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43

Muramatsu, Wataru. "Recent Advances in the Regioselective Functionalization of Carbohydrates Using Non-Enzymatic Catalysts." Trends in Glycoscience and Glycotechnology 28, no. 159 (2016): E1—E11. http://dx.doi.org/10.4052/tigg.1502.1e.

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Muramatsu, Wataru. "Recent Advances in the Regioselective Functionalization of Carbohydrates Using Non-Enzymatic Catalysts." Trends in Glycoscience and Glycotechnology 28, no. 159 (2016): J1—J11. http://dx.doi.org/10.4052/tigg.1502.1j.

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Wu, Huimin, Carla Silva, Yuanyuan Yu, Aixue Dong, Qiang Wang, Xuerong Fan, Ping Wang, Jiugang Yuan, and Artur Cavaco-Paulo. "Hydrophobic functionalization of jute fabrics by enzymatic-assisted grafting of vinyl copolymers." New Journal of Chemistry 41, no. 10 (2017): 3773–80. http://dx.doi.org/10.1039/c7nj00613f.

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Vecchiato, Sara, Jennifer Ahrens, Alessandro Pellis, Denis Scaini, Bernhard Mueller, Enrique Herrero Acero, and Georg M. Guebitz. "Enzymatic Functionalization of HMLS-Polyethylene Terephthalate Fabrics Improves the Adhesion to Rubber." ACS Sustainable Chemistry & Engineering 5, no. 8 (June 26, 2017): 6456–65. http://dx.doi.org/10.1021/acssuschemeng.7b00475.

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Dong, Aixue, Xuerong Fan, Qiang Wang, Yuanyuan Yu, and Artur Cavaco-Paulo. "Hydrophobic surface functionalization of lignocellulosic jute fabrics by enzymatic grafting of octadecylamine." International Journal of Biological Macromolecules 79 (August 2015): 353–62. http://dx.doi.org/10.1016/j.ijbiomac.2015.05.007.

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Ohta, Yukari, Ryoichi Hasegawa, Kanako Kurosawa, Allyn H. Maeda, Toshio Koizumi, Hiroshi Nishimura, Hitomi Okada, et al. "Enzymatic Specific Production and Chemical Functionalization of Phenylpropanone Platform Monomers from Lignin." ChemSusChem 10, no. 2 (December 16, 2016): 425–33. http://dx.doi.org/10.1002/cssc.201601235.

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Yataka, Yusuke, Toshiki Sawada, and Takeshi Serizawa. "Enzymatic synthesis and post-functionalization of two-dimensional crystalline cellulose oligomers with surface-reactive groups." Chemical Communications 51, no. 63 (2015): 12525–28. http://dx.doi.org/10.1039/c5cc04378f.

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Two-dimensional crystalline cellulose oligomers with surface-reactive azide groups were synthesized by enzymatic reactions and covalently post-functionalized with alkyne-containing dye molecules through click reactions.

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Arias-Gómez, Andres, Andrés Godoy, and Jaime Portilla. "Functional Pyrazolo[1,5-a]pyrimidines: Current Approaches in Synthetic Transformations and Uses As an Antitumor Scaffold." Molecules 26, no. 9 (May 5, 2021): 2708. http://dx.doi.org/10.3390/molecules26092708.

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Pyrazolo[1,5-a]pyrimidine (PP) derivatives are an enormous family of N-heterocyclic compounds that possess a high impact in medicinal chemistry and have attracted a great deal of attention in material science recently due to their significant photophysical properties. Consequently, various researchers have developed different synthesis pathways for the preparation and post-functionalization of this functional scaffold. These transformations improve the structural diversity and allow a synergic effect between new synthetic routes and the possible applications of these compounds. This contribution focuses on an overview of the current advances (2015–2021) in the synthesis and functionalization of diverse pyrazolo[1,5-a]pyrimidines. Moreover, the discussion highlights their anticancer potential and enzymatic inhibitory activity, which hopefully could lead to new rational and efficient designs of drugs bearing the pyrazolo[1,5-a]pyrimidine core.

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Journal articles on the topic 'Enzymatic functionalization'

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