Dissertations / Theses on the topic 'Environmental outcomes'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 dissertations / theses for your research on the topic 'Environmental outcomes.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.
Rowen, Zachary. "Are Streams Protected? Outcomes of Environmental Regulation." Thesis, University of North Texas, 2017. https://digital.library.unt.edu/ark:/67531/metadc1011867/.
Full textPohl, Raimund R. "An evaluation of the learning outcomes in environmental science from a field-based water quality environmental unit." Thesis, Curtin University, 1999. http://hdl.handle.net/20.500.11937/1260.
Full textBosco, Carol. "The Relationship Between Environmental Turbulence, Workforce Agility and Patient Outcomes." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/195013.
Full textJohnson, Brian. "Can Education Improve the Environment? Applying the Pressure-State-Response Environmental Indicator Framework to Environmental Education Program Outcomes." Antioch University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=antioch1375367966.
Full textPohl, Raimund R. "An evaluation of the learning outcomes in environmental science from a field-based water quality environmental unit." Curtin University of Technology, Science and Mathematics Education Centre, 1999. http://espace.library.curtin.edu.au:80/R/?func=dbin-jump-full&object_id=9584.
Full textTsai, Hui-Mei. "Cultural determinants of learning outcomes in global environmental education." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ37419.pdf.
Full textTruong, Khoa Dang. "Essays on environmental determinants of health behaviors and outcomes." Santa Monica, CA : RAND Corporation, 2008. http://www.rand.org/pubs/rgs%5Fdissertations/RGSD228/.
Full textTitle from title screen (viewed on June 13, 2008). This website links to the complete document in PDF format. Includes bibliographical references.
Ghosh, Rakesh. "Interaction between environmental factors and gender on perinatal outcomes." Thesis, University of Newcastle Upon Tyne, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.446230.
Full textWraith, Darren. "Bayesian mixture modelling for characterising environmental exposures and outcomes." Thesis, Queensland University of Technology, 2008. https://eprints.qut.edu.au/18467/1/Darren_Wraith_Thesis.pdf.
Full textWraith, Darren. "Bayesian mixture modelling for characterising environmental exposures and outcomes." Queensland University of Technology, 2008. http://eprints.qut.edu.au/18467/.
Full textGraham, Stephanie. "Environmental management in the UK food industry : antecedents and outcomes." Thesis, Queen's University Belfast, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.602513.
Full textShihadeh, Alan Louis 1967. "NOx control and environmental regulation : techniques and discriminatory social outcomes." Thesis, Massachusetts Institute of Technology, 1994. http://hdl.handle.net/1721.1/12285.
Full textKetcham, Cene Walstine. "Influence of Tree Planting Program Characteristics on Environmental Justice Outcomes." Thesis, Virginia Tech, 2015. http://hdl.handle.net/10919/56571.
Full textMaster of Science
Weltin, Meike [Verfasser]. "Sustainable intensification: Farmers’ adoption behaviour and environmental outcomes / Meike Weltin." Bonn : Universitäts- und Landesbibliothek Bonn, 2021. http://d-nb.info/1235525902/34.
Full textPius, Epie Ewanzimbi. "Significant outcomes of the West-Central African later Iron Age /." free to MU campus, to others for purchase, 2003. http://wwwlib.umi.com/cr/mo/fullcit?p3091957.
Full textGong, Yaping. "Staffing subsidiaries of multinational firms : Environmental antecedents and subsidiary level outcomes /." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1272986292.
Full textMendy, Angelico. "House dust endotoxin: associated respiratory outcomes and effectiveness of environmental interventions." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6613.
Full textGo, Jennifer. "Investigations Into the Effects of Gestational Exposure to Environmental Phthalates on Maternal and Perinatal Outcomes and the Role of Inflammation Biomarkers as Potential Mediators." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36925.
Full textNúñez, Rocha Thaís. "International trade and environment : the role of environmental regulations." Thesis, Paris 1, 2016. http://www.theses.fr/2016PA01E051/document.
Full textThis thesis contributes to an understanding of the relationship between trade and the environment, with an emphasis on the role of environmental regulation among countries. Three essays deal with this link from different perspectives. The first chapter analyses the effectiveness of the formalization of the Basel Convention on trade in hazardous wastes in the European Union (EU-WSR), followed by developing countries, and divided into regions. I build an environmental regulation index, which includes the quality of the institutions. The results show little evidence of a waste haven effect in the least developed EU countries. In the regional analysis, there is no evidence of the effectiveness of the EU-WSR. The second chapter examines the effectiveness of international environmental agreements. This chapter assesses the effects of the ratification and adoption of these agreements on imports of hazardous chemicals and persistent organic pollutants. The results underline the partial effect of these two conventions. More specifically, when assessing a less restrictive arrangement, imports are reduced only when the exporter ratifies the agreement. In assessing the ban on persistent organic pollutants, imports are reduced. The third examines the effect of environmental regulation on environmental outcomes. This chapter has taken into account the determinants of pollution and an environmental regulatory variable composed of environmental laws adopted by countries. The results show that environmental laws have an effect improving environmental outcomes. This effect is unique to environmental outcomes and to the law. Thus, some previous conclusions drawn from the literature on the beneficial effect of trade on the environment are questioned
Au, Felicia. "The Impact of Environmental Heavy Metal Exposures on Pregnancy and Birth Outcomes." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35558.
Full textAli, Basmah. "Multistakeholder collaboration outcomes in environmental voluntary initiatives : the case of A.R.E.T. initiative." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ59277.pdf.
Full textBashir, Imran, and Muhammad Sabir Shah. "CSR Implementation and Outcomes: The Environmental Concern : The Case of Axfood (Sweden)." Thesis, Karlstads universitet, Fakulteten för ekonomi, kommunikation och IT, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-30755.
Full textNelson, Edward. "Hydropower in Scotland : linking changing energy and environmental agendas with sustainability outcomes." Thesis, University of Stirling, 2013. http://hdl.handle.net/1893/20282.
Full textWestbrook, Johnnie Ray. "Enhancing Limited-Resource Farmers' Economic, Environmental, and Social Outcomes Through Extension Education." Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/39743.
Full textPh. D.
Perrotta, Allison Rose. "Microbial communities as predictors of outcomes in industrial and clinical applications." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/111446.
Full textCataloged from PDF version of thesis.
Includes bibliographical references.
Environmental and host associated microbial communities provide an extensive reservoir of genetic and functional diversity. This diversity represents a wealth of potential for applications in many fields. To harness this potential for engineering applications, the impact of temporal dynamics need to be better understood. Yet most of the data we have are in the form of static surveys of diversity. In this thesis, I use 16S rRNA sequencing analysis to measure community composition across time series to predict outcomes for three applications: bioreactor function; a non-invasive diagnostic of endometriosis; and commercial chicken rearing. I identify bacteria that exhibit distinct temporal dynamics within each application, and discuss the implications of those dynamics in the context of each application. Despite the diverse communities covered in this work, temporal dynamics emerge as a common theme that can impact these engineering applications which rely on stable and predictable community performance.
by Allison Rose Perrotta.
Ph. D. in Environmental Microbiology
Wilkinson, Tara Ann Cindy. "The Barbados Marine Reserve and involvement of fishers in its decision-making: outcomes, history, and processes." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107604.
Full textLes aires marines protégées (AMP) sont des éléments essentiels des stratégies de conservation marine, mais comme elles ont une incidence inévitable sur la pêche commerciale, sportive et de subsistence (et vice versa), la participation des intervenants dans la prise de décision est essentielle à leur réussite. À long terme, l'atteinte des objectifs de protection des ressources marines doit essentiellement passer par une évaluation et une révision rigoureuses de la participation. La présente thèse évalue les résultats de la participation des pêcheurs dans la prise de décision pour la Réserve marine de la Barbade (RMB) et se penche sur l'histoire de la réserve et sur les processus liés à la participation qui ont contribué à ces résultats. Pour les 108 intervenants qui se sont livrés à un entretien (55 pêcheurs et 53 utilisateurs rationnels (UR) des ressources, comme des employés du gouvernement, des plongeurs, des chercheurs et des conducteurs de bateaux), les résultats sont mitigés. L'implication des intervenants à l'égard de la RMB a changé au fil des années. Les étapes d'implication des intervenants dans les prises de décisions à l'égard de la RMB comprennent : a) négliger et marginaliser en grande partie les pêcheurs pendant sa création (fin des années 1970 et début des années 1980), b) effectuer des tentatives isolées subséquentes par l'entremise d'un « entrepreneur en stratégies » (Mascia 2000) d'inclure les pêcheurs et c) s'adresser directement aux pêcheurs pour les inclure dans les tables rondes (TR) demandant la participation des intervenants au cours de l'évaluation (fin des années 1990 et début des années 2000). Au cours de la dernière étape, le processus d'inclusion des pêcheurs dans la prise de décision a fluctué en termes de qualité. En général, les pêcheurs et les UR qui ont participé aux TR ont trouvé le rendement des facilitateurs acceptable. Même si les facilitateurs semblent avoir fait des efforts considérables pour inclure les pêcheurs, seuls quelques-uns ont participé, ce qui a diminué l'impact de leur présence. Ceux qui ont participé aux TR ont indiqué qu'ils avaient eu des occasions de discuter et qu'ils avaient été traités équitablement. Toutefois, ces aspects positifs ont été amoindris par des facilitateurs qui n'ont pas porté une attention suffisante aux éléments de procédure de la participation des intervenants, de même qu'à leurs facteurs historiques, culturels et socio-économiques, ce qui a mené à des résultats insuffisants. La plupart des intervenants croient au potentiel d'une AMP et à la théorie qui s'y rattache, et semblent avoir agi pour tirer profit de ses avantages (c.-à-d. qu'ils ont pêché aux limites de la réserve pour profiter des déversements ou des débordements). De plus, les pêcheurs qui ont participé au dernier processus d'implication pour la réserve (c.-à-d. aux TR) avaient des opinions et des avis plus favorables à propos de la RMB que ceux qui n'avaient pas participé. Par contre, malgré leur présence aux TR, la plupart des participants (les pêcheurs comme les UR) avaient l'impression qu'ils n'avaient pas été impliqués dans la prise de décisions relatives à la RMB. Donc, malgré le progrès effectué depuis la fin des années 1970, les débuts difficiles de la RMB n'ont pas été oubliés et les récentes améliorations semblent insuffisantes. Cette analyse a démontré que dans le cadre de la structuration de la participation des intervenants dans la gestion des AMP, une attention spéciale doit être portée à la qualité et aux éléments de procédure de la participation.
Brooks, Constance M. "Environmental risk factors and risky sexual behavior outcomes attitudes as a mediating factor /." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/4820.
Full textThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on September 19, 2007) Vita. Includes bibliographical references.
Rodríguez, Teresa. "Environmental Pesticide Exposure and Neurobehavioral Effects among Children of Nicaraguan Agricultural Workers." Doctoral thesis, Uppsala universitet, Institutionen för medicinska vetenskaper, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-182164.
Full textFrensley, B. Troy. "Investigating the links between lesson characteristics, student engagement, and outcomes at a residential environmental education program." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/83826.
Full textPh. D.
Cil, Gulcan. "Effects of Behavioral and Environmental Factors on Infant Health." Thesis, University of Oregon, 2015. http://hdl.handle.net/1794/19316.
Full textJones, A. "Measuring and managing social, economic and environmental outcomes in the English social housing sector." Thesis, Nottingham Trent University, 2015. http://irep.ntu.ac.uk/id/eprint/27716/.
Full textFrederick, Emilia. "Predicting child developmental outcomes from family environmental factors: Findings from the Bayley-4 Project." Thesis, Frederick, Emilia (2020) Predicting child developmental outcomes from family environmental factors: Findings from the Bayley-4 Project. Masters by Coursework thesis, Murdoch University, 2020. https://researchrepository.murdoch.edu.au/id/eprint/60738/.
Full textMcLean, Kevin Daniel. "Interpreter Attributes and Their Impact on Visitor Outcomes in National Park Service Interpretive Programs." Thesis, Virginia Tech, 2013. http://hdl.handle.net/10919/19288.
Full textMaster of Science
Mason, Rachel. "Modeling Agricultural Outcomes in a Warmer, Wetter Vermont." ScholarWorks @ UVM, 2019. https://scholarworks.uvm.edu/graddis/1034.
Full textButtling, Lauren G. "Maternal Residential Proximity to Central Appalachian Surface Mining and Adverse Birth Outcomes." Thesis, Virginia Tech, 2020. http://hdl.handle.net/10919/98651.
Full textM.S.
Central Appalachian surface mining produces air, water, and noise pollution, all of which have been associated with increased risk of adverse birth outcomes. Previous studies examining associations between surface mining and adverse birth outcomes rely upon relatively coarse county-level data. This research compares outcomes from hundreds of thousands of individual birth records and proximity of maternal home address to surface mines for a fine-scale, epidemiological study. Surface mining boundaries between 1986-2015 were developed using satellite imagery. Birth records from VA, WV, KY, and TN were geocoded and assigned the amount of surface mining within a 5km radius of residence. Births were also assigned exposures based on the amount of surface mining within residential ZIP code since geocoding led to a considerable loss of records. Associations between proximity to surface mining during gestation and birth weight, preterm birth (PTB), low birth weight (LBW), and term low birth weight (tLBW) were determined by linear and logistic regression, adjusting for available demographic factors. Results demonstrate significantly decreased birth weights were found near active mining operations. Mothers living near active surface mining also saw a slight increase in the odds of their birth being PTB, LBW or tLBW. These results suggest there is a subtle, but significant relationship between proximity to surface mining and adverse birth outcomes.
Núñez, Rocha Thaís. "International trade and environment : the role of environmental regulations." Electronic Thesis or Diss., Paris 1, 2016. http://www.theses.fr/2016PA01E051.
Full textThis thesis contributes to an understanding of the relationship between trade and the environment, with an emphasis on the role of environmental regulation among countries. Three essays deal with this link from different perspectives. The first chapter analyses the effectiveness of the formalization of the Basel Convention on trade in hazardous wastes in the European Union (EU-WSR), followed by developing countries, and divided into regions. I build an environmental regulation index, which includes the quality of the institutions. The results show little evidence of a waste haven effect in the least developed EU countries. In the regional analysis, there is no evidence of the effectiveness of the EU-WSR. The second chapter examines the effectiveness of international environmental agreements. This chapter assesses the effects of the ratification and adoption of these agreements on imports of hazardous chemicals and persistent organic pollutants. The results underline the partial effect of these two conventions. More specifically, when assessing a less restrictive arrangement, imports are reduced only when the exporter ratifies the agreement. In assessing the ban on persistent organic pollutants, imports are reduced. The third examines the effect of environmental regulation on environmental outcomes. This chapter has taken into account the determinants of pollution and an environmental regulatory variable composed of environmental laws adopted by countries. The results show that environmental laws have an effect improving environmental outcomes. This effect is unique to environmental outcomes and to the law. Thus, some previous conclusions drawn from the literature on the beneficial effect of trade on the environment are questioned
Sweet, Laura Louise. "The Impact of an Urban Intervention to Mediate Indoor Environmental Hazards on Asthma Outcomes in Children." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1343509149.
Full textTshikuka, Mulumba Jose-Gaby. "Relationships between environmental risk factors, parasitic infections and health outcomes in an urban African setting." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40014.
Full textPratson, Daniel Francis. "An investigation of environmental education instructors: motivations, autonomy, experience, and their influences on student outcomes." Thesis, Virginia Tech, 2019. http://hdl.handle.net/10919/91387.
Full textMaster of Science
Environmental education (EE) programming has been found to lead to positive behavioral and attitudinal outcomes in student participants. Among a variety of factors, the characteristics of EE program instructors have been found to play a role in driving these outcomes. This thesis investigates the specific motivators of EE instructors and the links between instructor autonomy, prior experience, and program outcomes. I used a multi-methods approach, employing semi-structured interviews and surveys to investigate these themes, and have organized the results between two chapters that are manuscripts intended as separate journal publications. Chapter 2 presents a qualitative study that identifies the salient motivators of EE instructors, as well as organizational practices that affect EE instructor feelings of autonomy, competence, relatedness, and the meaningfulness these instructors feel within their jobs. Chapter 3 presents a quantitative study analyzing the impact of autonomy and prior experience on program outcomes by linking instructor and student participant survey responses from a sample of 166 EE programs performed throughout 57 different organizations across the US. Results led to the following recommendations for EE organizations: (1) promote job enrichment elements for their instructional staff, including the implementing of participatory evaluation processes; (2) encourage instructors to take “ownership” of programming, such that they continue to practice and develop competence over time; (3) increase instructor autonomy as they gain further experience. This research provides information to better EE organizational management in the aims of promoting motivated employees and ultimately effective program outcomes.
Twigg, Sarah. "Unravelling the biological, environmental, physical and psychosocial factors impinging on outcomes in early rheumatoid arthritis." Thesis, University of Leeds, 2014. http://etheses.whiterose.ac.uk/8421/.
Full textFolke, Olle. "Politics and preferences : explanations to policy outcomes in Swedish municipalities /." Uppsala : Dept. of Economics, Swedish University of Agricultural Sciences, 2008. http://epsilon.slu.se/10862558.pdf.
Full textShishehbor, Mehdi H. "Mediating Pathways That Link Contextual Risk Factors to All-Cause Mortality and Clinical Outcomes." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1377537452.
Full textEstornell, Paula Haas Charles N. Brulle Robert J. "Sustainable development : which policy process - autocratic or democratic-leads to more durable policy and environmental outcomes?" Philadelphia, Pa. : Drexel University, 2010. http://hdl.handle.net/1860/3312.
Full textYang, Ma Ga. "Developing a Focal Firm’s Sustainable Supply Chain Framework: Drivers, Orientation, Practices and Performance Outcomes." University of Toledo / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1356543598.
Full textCunningham, Natalie Lorinda. "The profile and outcomes of stroke patients discharged from a hospital In the Eastern Cape." Thesis, University of Western Cape, 2012. http://hdl.handle.net/11394/3368.
Full textStroke is the third leading cause of death and disability worldwide. The Uitenhage Provincial Hospital admits many stroke patients. To date, no in-depth study has been conducted on stroke patients admitted to the Hospital. This study identified the profile of stroke patients admitted to the Uitenhage Provincial Hospital and explored the challenges that these patients experienced post stroke. A concurrent mixed model design was used to collect the data. Firstly retrospective data was obtained by means of a quantitative data gathering instrument designed by the researcher. The information obtained, included data relating to demographic characteristics, reported risk factors relating to stroke, stroke onset-admission interval and length of hospital stay, as well as information relating to the process of physiotherapy. Secondly quantitative prospective information was collected by means of the Barthel Index, the Modified Rankin Scale and the Facilitators And Barriers Survey. The sample for the quantitative phase was drawn from medical records of 168 stroke patients admitted to the Uitenhage Provincial Hospital from the 1 of January 2008 up to and including the 31 of December 2009. For the second prospective quantitative part of the study, participants were selected conveniently from the admitted patients. In the qualitative phase, nine participants taken of the sampled participants were selected. The Microsoft Excel 2007 Package and the SPSS 18 for social sciences were used to analyse the quantitative data. Means, standard deviations, frequencies and percentages were calculated for descriptive purposes and the Chi-square test was used to test for associations between variables. Qualitative analysis began with the transcription of voice recordings and the translation of relevant Afrikaans transcription into English. Emerging categories were identified within the pre-determined themes. Permission and ethical clearance was obtained from the Higher Degrees Committee and the Senate Research and Grants and Study Leave Committee of the University of the Western Cape and permission to conduct this study was also obtained from the Medical Superintendent of the Uitenhage Provincial Hospital. Altogether 461 patients had been admitted with stroke during the relevant period, but only 168 could be included in the retrospective quantitative study. The mean age of the participants was 61,54 years; 59% were females and 41% males. The majority of the participants (86,9%) were admitted on the same day of stroke onset, and the mean length of hospital stay was 7,38 days. Hypertension was the most common reported risk factor, at 79%. Only 165 of the participants received physiotherapy while hospitalised, with the mean total physiotherapy sessions being 2,56 sessions. In 90% of the cases, physiotherapy sessions were discontinued due to the patient being discharged from the Hospital. The mean Barthel Index score was 81,46 and the family care domain of the Modified Rankin Scale was the most affected. Participants experienced participation restrictions and activity limitations due to stairs, gravel surfaces and kerb cuts. During the qualitative interviews participants reported activity limitations related to walking and activities of daily living. The participants also experienced participation restrictions, which included dependency on others, decreased social support and an array of emotions experienced post stroke. The current study’s findings suggest that the discharge of patients from the hospital post stroke should follow a mulitidisciplinary approach. Rehabilitation professionals should play an active role in the discharge process in providing patient and caregiver education.
Marin, Maria M. "The Effects of Classroom Environmental Quality on the Early Literacy Outcomes of a Regionally Heterogeneous Population of Latino Children." FIU Digital Commons, 2010. http://digitalcommons.fiu.edu/etd/162.
Full textSeryak, Liesel M. "Factors and Outcomes Associated with Bisphenol A Exposure in Women of Reproductive Age." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1355885304.
Full textLee, Hannah Garrett. "Assessing the influence of preparation and follow-up on student outcomes associated with environmental education field trips." Thesis, Virginia Tech, 2019. http://hdl.handle.net/10919/91465.
Full textMaster of Science
Environmental and science education in the form of school field trips have the capability of to enhance student learning, increase motivation to do well in school, and develop skills such as thinking critically and collaborating with peers. Learning theory illuminates the importance of in-school preparation and reflection surrounding field trips. We wanted to discover what happens in the classroom before and after these field trips that contribute to creating truly valuable educational experiences. Student and teacher surveys from over 300 field trip programs highlight the importance of preparing students both logistically and with the educational content, as well as following-up after the field trip by reviewing and utilizing newly gained knowledge and skills. We recommend schools and field trip providers, such as parks, zoos and nature centers, collaborate to create more holistic science learning experiences.
Keith, Nathan. "The Influence of Chemical Pollution on the Rate, Spectra, and Distribution of Genome-Wide DNA Mutation with Considerations for Health and Ecosystem Outcomes." Thesis, Indiana University, 2019. http://pqdtopen.proquest.com/#viewpdf?dispub=13808392.
Full textMutations are the ultimate source of genetic variation. Understanding the rate and environmental influence on mutation rate is therefore critical for understanding the origin of human disease and all evolutionary change. Environments, including chemical environments, are rapidly changing around the globe. Over the past seven decades, more than 140,000 novel chemicals have introduced into the market. However, less than 2% of these chemicals have been thoroughly characterized with toxicological assays.
Because the majority of germline mutations have a neutral or negative impact on fitness, pollutant-induced mutagenesis can be devastating for ecosystems and can increase the rate of human disease. However, the influence of chemicals on the rate of germline mutation has been largely ignored. We therefore utilized Daphnia pulex to, (1) characterize the rate and spectrum of genome-wide mutation, (2) measure the influence of chronic, cadmium exposure on the germline mutation rate, and (3) investigate if adaptation protects the germline from mutagenesis.
The single nucleotide mutation (SNM) rate in D. pulex is similar to other model organisms. However, the rate of large-scale de novo copy number variants is 10 to 100-fold higher than other organismal models and is identical to the estimated rate in humans. Exposure to cadmium was mutagenic in the germline, altering the genome-wide rates and spectra of multiple SNM classes and changing the SNM rates in multiple genome regions. Since drastic, pollutant-induced changes to germline mutation have not previously been described, we developed a quantitative model for predicting population response to mutagenic pollutants. Finally, with a cadmium-adapted genotype we show adaptation protects the germline from cadmium-induced mutagenesis. The knowledge gained through this research stands to have profound implications for society and the long-term health of populations, which are living longer in the presence of a growing diversity of potentially mutagenic chemicals.
Soloway, Julie A. "Institutional capacity to constrain suboptimal welfare outcomes from trade-restricting environmental, health and safety regulation under NAFTA." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ49919.pdf.
Full text