Academic literature on the topic 'Environmental Association Analysis'

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Journal articles on the topic "Environmental Association Analysis"

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Rellstab, Christian, Felix Gugerli, Andrew J. Eckert, Angela M. Hancock, and Rolf Holderegger. "A practical guide to environmental association analysis in landscape genomics." Molecular Ecology 24, no. 17 (August 26, 2015): 4348–70. http://dx.doi.org/10.1111/mec.13322.

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Osereme Amiolemen, Omoike, Uwalomwa Uwuigbe, Olubukola Ranti Uwuigbe, Ilogho Simon Osiregbemhe, and Ajetunmobi Opeyemi. "Corporate social environmental reporting and stock prices: an analysis of listed firms in Nigeria." Investment Management and Financial Innovations 15, no. 3 (September 21, 2018): 318–28. http://dx.doi.org/10.21511/imfi.15(3).2018.26.

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The study investigated Corporate Social Environmental Reporting and its association with stock prices (using market price per share as at the financial year end) among listed firms in Nigeria. The study used a cross-sectional research design comprising 50 publicly listed companies across various sectors for the period of five years (2011–2015). For the selected firms, the annual report was used to collect the data. This research utilizes the panel data regression in analyzing the influence of the independent variable (measured by corporate social and environmental expenditure) on the dependent variable measured using the market price per share) for the respective years. Also, in an attempt to examine the relatively market price per share across the sampled industries, the study made use of the one-way analysis of variance; while the Granger causality test was also conducted to ascertain whether bi-directional relationships exist between explanatory variable and the dependent variable (i.e. corporate social and environmental expenditure and market price per share). Findings from the study revealed that the association between corporate social and environmental expenditure and the market price of the firm (when considered in aggregate) is not significant. The result from the Analysis of Variance (ANOVA) showed that the market price per share is significantly different across the industries.
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Acar, Merve, and Hüseyin Temiz. "Empirical analysis on corporate environmental performance and environmental disclosure in an emerging market context." International Journal of Emerging Markets 15, no. 6 (March 19, 2020): 1061–82. http://dx.doi.org/10.1108/ijoem-04-2019-0255.

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PurposeThe purpose of this study is to investigate the association between environmental performance of firms and the level of voluntary environmental disclosure in emerging markets.Design/methodology/approachWe used tobit regression OLS and t-test methods to reveal the association between environmental performance and the level of voluntary environmental disclosure.FindingsWe find a significant positive association between the level of discretionary environmental disclosures and corporate environmental performance. The result is in line with the arguments of economics disclosure theory that argues environmentally good performers disclose more.Practical implicationsMany of the environmentally good firms in Turkey are also listed in the “BIST Sustainability Index,” and this situation can be the result of the relative power of external regulations. Accordingly, it can be suggested to increase the community and governmental pressures for environmental reporting but also gives importance to increase intrinsic motivations for companies to engage in disclosure practices.Originality/valueThis study shed light on relation between environmental performance and environmental disclosure in an emerging market context. Also, it is revisited that the relation between environmental performance and the level of environmental disclosure by testing two different predictions on the level of environmental disclosures.
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Hassan, Syeda Anam. "Investigating the Relationship of E-Government, Control of Corruption, Economic Prosperity and Environmental Degradation: An Analysis of Asian Region." International Journal of Innovation and Economic Development 3, no. 2 (2017): 18–28. http://dx.doi.org/10.18775/ijied.1849-7551-7020.2015.32.2002.

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To generate and maintain sustainable economic growth, e-government and control of corruption are considered as a key contributor in the nation. E-government not only increases control of corruption and economic growth but also reduces environmental degradation. In this study, the relationship of e-government to control of corruption, economic prosperity and environmental degradation has been investigated. Government has a positive and significant association with economic prosperity and control of corruption. However, e-government negatively related to S curve. The impact of control variables such that manufacturing, working for population and political stability all are positive to economic prosperity while exports and urban population show a negative association with the economic prosperity. In the case of environmental degradation, manufacturing and working population shows negative relationship while exports, political stability, and urban population shows a positive association with the environmental degradation. The study suggests that constructive national policies by practitioners and policy makers are required for the development of e-government.
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Zheng, Yuejun. "Association Analysis on Pro-Environmental Behaviors and Environmental Consciousness in Main Cities of East Asia." Behaviormetrika 37, no. 1 (January 2010): 55–69. http://dx.doi.org/10.2333/bhmk.37.55.

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Jelenkovic, Aline, Janne Mikkonen, Pekka Martikainen, Antti Latvala, Yoshie Yokoyama, Reijo Sund, Eero Vuoksimaa, et al. "Association between birth weight and educational attainment: an individual-based pooled analysis of nine twin cohorts." Journal of Epidemiology and Community Health 72, no. 9 (May 30, 2018): 832–37. http://dx.doi.org/10.1136/jech-2017-210403.

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BackgroundThere is evidence that birth weight is positively associated with education, but it remains unclear whether this association is explained by familial environmental factors, genetic factors or the intrauterine environment. We analysed the association between birth weight and educational years within twin pairs, which controls for genetic factors and the environment shared between co-twins.MethodsThe data were derived from nine twin cohorts in eight countries including 6116 complete twin pairs. The association between birth weight and educational attainment was analysed both between individuals and within pairs using linear regression analyses.ResultsIn between-individual analyses, birth weight was not associated with educational years. Within-pairs analyses revealed positive but modest associations for some sex, zygosity and birth year groups. The greatest association was found in dizygotic (DZ) men (0.65 educational years/kg birth weight, p=0.006); smaller effects of 0.3 educational years/kg birth weight were found within monozygotic (MZ) twins of both sexes and opposite-sex DZ twins. The magnitude of the associations differed by birth year in MZ women and opposite-sex DZ twins, showing a positive association in the 1915–1959 birth cohort but no association in the 1960–1984 birth cohort.ConclusionAlthough associations are weak and somewhat inconsistent, our results suggest that intrauterine environment may play a role when explaining the association between birth weight and educational attainment.
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Mannion, Philip D., and Paul Upchurch. "A quantitative analysis of environmental associations in sauropod dinosaurs." Paleobiology 36, no. 2 (2010): 253–82. http://dx.doi.org/10.1666/08085.1.

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Both the body fossils and trackways of sauropod dinosaurs indicate that they inhabited a range of inland and coastal environments during their 160-Myr evolutionary history. Quantitative paleoecological analyses of a large data set of sauropod occurrences reveal a statistically significant positive association between non-titanosaurs and coastal environments, and between titanosaurs and inland environments. Similarly, “narrow-gauge” trackways are positively associated with coastal environments and “wide-gauge” trackways are associated with inland environments. The statistical support for these associations suggests that this is a genuine ecological signal: non-titanosaur sauropods preferred coastal environments such as carbonate platforms, whereas titanosaurs preferred inland environments such as fluvio-lacustrine systems. These results remain robust when the data set is time sliced and jackknifed in various ways. When the analyses are repeated using the more inclusive groupings of titanosauriforms and Macronaria, the signal is weakened or lost. These results reinforce the hypothesis that “wide-gauge” trackways were produced by titanosaurs. It is commonly assumed that the trackway and body fossil records will give different results, with the former providing a more reliable guide to the habitats occupied by extinct organisms because footprints are produced during life, whereas carcasses can be transported to different environments prior to burial. However, this view is challenged by our observation that separate body fossil and trackway data sets independently support the same conclusions regarding environmental preferences in sauropod dinosaurs. Similarly, analyzing localities and individuals independently results in the same environmental associations. We demonstrate that conclusions about environmental patterns among fossil taxa can be highly sensitive to an investigator's choices regarding analytical protocols. In particular, decisions regarding the taxonomic groupings used for comparison, the time range represented by the data set, and the criteria used to identify the number of localities can all have a marked effect on conclusions regarding the existence and nature of putative environmental associations. We recommend that large data sets be explored for such associations at a variety of different taxonomic and temporal scales.
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Barclay, N. L., T. C. Eley, B. Maughan, R. Rowe, and A. M. Gregory. "Associations between diurnal preference, sleep quality and externalizing behaviours: a behavioural genetic analysis." Psychological Medicine 41, no. 5 (September 14, 2010): 1029–40. http://dx.doi.org/10.1017/s0033291710001741.

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BackgroundCertain aspects of sleep co-occur with externalizing behaviours in youth, yet little is known about these associations in adults. The present study: (1) examines the associations between diurnal preference (morningness versus eveningness), sleep quality and externalizing behaviours; (2) explores the extent to which genetic and environmental influences are shared between or are unique to these phenotypes; (3) examines the extent to which genetic and environmental influences account for these associations.MethodQuestionnaires assessing diurnal preference, sleep quality and externalizing behaviours were completed by 1556 young adult twins and siblings.ResultsA preference for eveningness and poor sleep quality were associated with greater externalizing symptoms [r=0.28 (95% CI 0.23–0.33) and 0.34 (95% CI 0.28–0.39), respectively]. A total of 18% of the genetic influences on externalizing behaviours were shared with diurnal preference and sleep quality and an additional 14% were shared with sleep quality alone. Non-shared environmental influences common to the phenotypes were small (2%). The association between diurnal preference and externalizing behaviours was mostly explained by genetic influences [additive genetic influence (A)=80% (95% CI 0.56–1.01)], as was the association between sleep quality and externalizing behaviours [A=81% (95% CI 0.62–0.99)]. Non-shared environmental (E) influences accounted for the remaining variance for both associations [E=20% (95% CI −0.01 to 0.44) and 19% (95% CI 0.01–0.38), respectively].ConclusionsA preference for eveningness and poor sleep quality are moderately associated with externalizing behaviours in young adults. There is a moderate amount of shared genetic influences between the phenotypes and genetic influences account for a large proportion of the association between sleep and externalizing behaviours. Further research could focus on identifying specific genetic polymorphisms common to both sleep and externalizing behaviours.
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Ojha, Rohit P., Martha M. Phillips, and Raymond Thertulien. "Population-Based Risk Assessment for Multiple Myeloma: A Novel Approach for Identifying Potential Environmental Associations." Blood 106, no. 11 (November 16, 2005): 5058. http://dx.doi.org/10.1182/blood.v106.11.5058.5058.

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Abstract Given the continued uncertainty of multiple myeloma (MM) etiology, environmental epidemiologic investigations remain an important approach for generating hypotheses regarding potentially significant exposures. We assessed MM incidence in Arkansas using a novel population-based approach that combines county agricultural and industrial characteristics with environmental hazard mapping techniques to determine case distribution throughout the state and to identify significant trends associated with case distribution. Our investigation revealed a significant association between manufacturing-dependent counties and MM incidence (OR = 1.26, p = 0.004), a significant inverse association between non-specialized counties and MM incidence (OR = 0.62, p < 0.00001), and no significant association between agriculture-dependent counties and MM incidence (OR=0.92, p=0.636). Analyses of sixteen selected industries and their associations with MM incidence revealed primarily wood-related industries (paper mills, sawmills, wood preservation, and softwood, veneer and plywood manufacturing) exhibited significant associations with MM incidence (OR= 1.79 – 2.02, p< 0.05). Trend analyses demonstrated increasing MM incidence with increasing proportion of the population employed in the aforementioned wood-related industries. This is the first such statewide assessment of associations between general environmental exposure and MM incidence within counties. The methods developed in this study can be applied to data from other states or regions to produce a larger body of information from several geographic areas regarding MM incidence or other disorders with suspected environmental associations. Subsequently, meta-analysis can be performed to support or refute the existence of apparent associations, provide insight regarding national trends of MM incidence, and potentially suggest additional sources of exposure for further investigation.
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Hermanussen, Michael, Christian Aßmann, and Detlef Groth. "Chain Reversion for Detecting Associations in Interacting Variables—St. Nicolas House Analysis." International Journal of Environmental Research and Public Health 18, no. 4 (February 11, 2021): 1741. http://dx.doi.org/10.3390/ijerph18041741.

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(1) Background: We present a new statistical approach labeled as “St. Nicolas House Analysis” (SNHA) for detecting and visualizing extensive interactions among variables. (2) Method: We rank absolute bivariate correlation coefficients in descending order according to magnitude and create hierarchic “association chains” defined by sequences where reversing start and end point does not alter the ordering of elements. Association chains are used to characterize dependence structures of interacting variables by a graph. (3) Results: SNHA depicts association chains in highly, but also in weakly correlated data, and is robust towards spurious accidental associations. Overlapping association chains can be visualized as network graphs. Between independent variables significantly fewer associations are detected compared to standard correlation or linear model-based approaches. (4) Conclusion: We propose reversible association chains as a principle to detect dependencies among variables. The proposed method can be conceptualized as a non-parametric statistical method. It is especially suited for secondary data analysis as only aggregate information such as correlations matrices are required. The analysis provides an initial approach for clarifying potential associations that may be subject to subsequent hypothesis testing.
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Dissertations / Theses on the topic "Environmental Association Analysis"

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Guzman, Martha Elva Ramierez. "Characterization of the association between short-term variations in daily mortality and adverse environmental conditions using time series methodology." Thesis, University of Reading, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253129.

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Weston, William Christopher. "A SPATIAL ANALYSIS OF INVASIVE BREAST CANCER CLUSTERS IN ASSOCIATION WITH ENVIRONMENTAL RISK FACTORS: ILLINOIS 1996 TO 2000." OpenSIUC, 2012. https://opensiuc.lib.siu.edu/theses/896.

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This retrospective study assesses invasive breast cancer counts reported at the Illinois ZIP code scale during the study period of 1996 to 2000. The research objective is to evaluate the spatial and statistical associations between breast cancer risk and sources of potential environmental contamination. A thorough literature review illustrates a profound list of cancer risk factors within the study space. Public health principles are utilized to prepare breast cancer incidence for analysis, accompanied with the development of a case/control ecological model. Exploratory analyses suggest that breast cancer intensity is predominantly a rural problem. A generalized linear mixed model is employed, illustrating statistical associations between environmental risk factors and breast cancer risk. Coal Mines, Oil/Gas Wells, and Large Quantity Hazardous Waste Generators, display high statistical significance (p<0.001) in association with increased breast cancer risk. Unique socioeconomic attributes distinguish urban risk from rural risk, as can be seen in a discriminant function analysis. The modeling techniques utilized in this research display classic spatial epidemiological approaches that account for particular types of confounding effects, while also defining zones of disease risk through cluster detection. Results from this analysis are useful for future studies intended to account for epidemiological, clinical, chemical and biological disease-related information.
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Hall, Callyn. "An Analysis of the Association between Animal Exposures and the Development of Type 1 Diabetes in the TEDDY Cohort." Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4501.

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Research on exposure to animals and risk of type 1 diabetes (T1D) has had conflicting results with some researchers finding that animal exposure reduces the risk of T1D and others finding no association between animal exposure and T1D. Previously conducted studies on the association between animal exposure and T1D are case-control studies that have been limited by recall bias. The purpose of this study is to investigate the association between early life animal exposure and the risk of persistent, confirmed islet autoantibodies (IA) and T1D diagnosis among an eligible cohort of genetically high T1D risk participants enrolled in the international prospective cohort study, The Environmental Determinants of Diabetes in the Young (TEDDY). It is hypothesized that children who are exposed to animals in early life will have a lower risk of developing IA and T1D than children who are not exposed to animals in early life. A total of 7,432 TEDDY participants were included in the study. The associations between early life animal exposure and the outcomes of interest were explored using Cox proportional hazards models. In order to control for confounding, a propensity score analysis was applied by three different methods: adjustment for the propensity score variable in the Cox proportional hazards model, stratification on propensity score groups, and propensity score pair matching. Early life animal exposure was not associated with diabetes autoimmunity or T1D onset in this genetically high T1D risk population. These findings were consistent across all three propensity score analysis methods and when directly adjusting for HLA type. The hypothesis that children who are exposed to animals in early life will have a lower risk of developing IA and T1D than children who are not exposed to animals in early life is not supported by this study. The results of this study suggest that there is no association between early life animal exposure and development of T1D. Performing this analysis again after longer follow-up has been completed for the study population is recommended as it may elucidate the effect of animal exposure on T1D and IA risk. Further studies are also needed on animal exposure and T1D in different types of environments (e.g., high residential density) and the effect of different types of animal exposures (e.g., species, duration) on T1D and IA risk. Additionally, studies on differences in perceptions of pets across countries could also aid the interpretation of studies on animal exposure and health outcomes.
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Webbe, Jaime Alexandra. "An analysis of the feasibility of developing a network of residential outdoor schools within the Canadian Biosphere Reserve Association /." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33947.

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Residential outdoor schools are multi-day learning camps that provide unique settings in which to deliver environmental education. However, such schools are also very complex to develop and difficult to maintain and operate. Within Canada though, there are many examples of successful outdoor school operations, three of which are considered here: the North Vancouver Outdoor School, the Olympic Park Institute and the Golden Ears Learning Centre. From these case studies lessons can be learned regarding issues such as: land tenureship, program design, staffing options, administrative systems, facility requirements, finance options and abilities to attract students. The discussion of these factors can then be applied to the development of a nation wide network of residential outdoor schools within the framework of Canadian Biosphere Reserves.
Currently there are ten Biosphere Reserves in Canada which, when analyzed, prove to be very adequate sites for environmental education from both physical and social stand points. The Canadian Biosphere Reserve Association is the coordinating body which fosters communication and cooperation between individual Reserves. If a network of residential outdoor schools were to be developed within this association framework, it would serve, both to fulfill the Canadian Biosphere Reserve Associations mandate to support environmental education and would help partially alleviate the lack of adequate environmental education facilities in Canada today.
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Tamulis, Tomas. "Association between area socioeconomic status and hospital admissions for childhood and adult asthma." [Tampa, Fla.] : University of South Florida, 2005. http://purl.fcla.edu/fcla/etd/SFE0001134.

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Singh, Sandeep Kumar. "A Case-Only Genome-wide Association Study of Gender- and Age-specific Risk Markers for Childhood Leukemia." FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/1832.

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Males and age group 1 to 5 years show a much higher risk for childhood acute lymphoblastic leukemia (ALL). We performed a case-only genome-wide association study (GWAS), using the Illumina Infinium HumanCoreExome Chip, to unmask gender- and age-specific risk variants in 240 non-Hispanic white children with ALL recruited at Texas Children’s Cancer Center, Houston, Texas. Besides statistically most significant results, we also considered results that yielded the highest effect sizes. Existing experimental data and bioinformatic predictions were used to complement results, and to examine the biological significance of statistical results. Our study identified novel risk variants for childhood ALL. The SNP, rs4813720 (RASSF2), showed the statistically most significant gender-specific associations (P < 2 x 10-6). Likewise, rs10505918 (SOX5) yielded the lowest P value (P < 1 x 10-5) for age-specific associations, and also showed the statistically most significant association with age-at-onset (P < 1 x 10-4). Two SNPs, rs12722042 and 12722039, from the HLA-DQA1 region yielded the highest effect sizes (odds ratio (OR) = 15.7; P = 0.002) for gender-specific results, and the SNP, rs17109582 (OR = 12.5; P = 0.006), showed the highest effect size for age-specific results. Sex chromosome variants did not appear to be involved in gender-specific associations. The HLA-DQA1 SNPs belong to DQA1*01:07and confirmed previously reported male-specific association with DQA1*01:07. Twenty one of the SNPs identified as risk markers for gender- or age-specific associations were located in the transcription factor binding sites and 56 SNPs were non-synonymous variants, likely to alter protein function. Although bioinformatic analysis did not implicate a particular mechanism for gender- and age-specific associations, RASSF2 has an estrogen receptor-alpha binding site in its promoter. The unknown mechanisms may be due to lack of interest in gender- and age-specificity in associations. These results provide a foundation for further studies to examine the gender- and age-differential in childhood ALL risk. Following replication and mechanistic studies, risk factors for one gender or age group may have a potential to be used as biomarkers for targeted intervention for prevention and maybe also for treatment.
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Xin, Xiachi. "Architecture of human complex trait variation." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31549.

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A complex trait is a trait or disease that is controlled by both genetic and environmental factors, along with their interactions. Trait architecture encompasses the genetic variants and environmental causes of variation in the trait or disease, their effects on the trait or disease and the mechanism by which these factors interact at molecular and organism levels. It is important to understand trait architecture both from a biological viewpoint and a health perspective. In this thesis, I laid emphasis on exploring the influence of familial environmental factors on complex trait architecture alongside the genetic components. I performed a variety of studies to explore the architecture of anthropometric and cardio-metabolic traits, such as height, body mass index, high density lipoprotein content of blood and blood pressure, using a cohort of 20,000 individuals of recent Scottish descent and their phenotype measurements, Single Nucleotide Polymorphism (SNP) data and genealogical information. I extended a method of variance component analysis that could simultaneously estimate SNP-associated heritability and total heritability whilst considering familial environmental effects shared among siblings, couples and nuclear family members. I found that most missing heritability could be explained by including closely related individuals in the analysis and accounting for these close relationships; and that, on top of genetics, couple and sibling environmental effects are additional significant contributors to the complex trait variation investigated. Subsequently, I accounted for couple and sibling environmental effects in Genome- Wide Association Study (GWAS) and prediction models. Results demonstrated that by adding additional couple and sibling information, both GWAS performance and prediction accuracy were boosted for most traits investigated, especially for traits related to obesity. Since couple environmental effects as modelled in my study might, in fact, reflect the combined effect of assortative mating and shared couple environment, I explored further the dissection of couple effects according to their origin. I extended assortative mating theory by deriving the expected resemblance between an individual and in-laws of his first-degree relatives. Using the expected resemblance derived, I developed a novel pedigree study which could jointly estimate the heritability and the degree of assortative mating. I have shown in this thesis that, for anthropometric and cardio-metabolic traits, environmental factors shared by siblings and couples seem to have important effects on trait variation and that appropriate modelling of such effects may improve the outcome of genetic analyses and our understanding of the causes of trait variation. My thesis also points out that future studies on exploring trait architecture should not be limited to genetics because environment, as well as mate choice, might be a major contributor to trait variation, although trait architecture varies from trait to trait.
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Horne, Murray R. "Associative analysis of spatial learning in environments with a distinctive shape." Thesis, Cardiff University, 2009. http://orca.cf.ac.uk/55831/.

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The aim of this thesis was to evaluate the proposal by Miller and Shettleworth (2007) that learning about geometric cues in environments with a distinctive shape is governed by a competitive learning rule (e.g., Rescorla & Wagner, 1972). To do this, in all experiments, rats were trained to locate a hidden platform by reference to the shape of a swimming pool. Chapter 2 (Experiments 1 -4) assessed whether a landmark suspended above the platform would overshadow learning about geometric cues. No overshadowing was recorded, even when the salience of the geometric cues was reduced. These findings are inconsistent with the model of Miller and Shettleworth (2007). In Chapter 3 (Experiments 5-7), a blocking paradigm was used. When rats were given extended pre-training with a landmark above the platform, only then did the landmark successfully block learning about geometric cues. However, some unexpected findings suggested that perhaps the spatial cues were competing for attention rather than associative strength. The experiments in Chapter 4 (Experiments 8 and 9) successfully demonstrated superconditioning of geometric cues by an inhibitory landmark providing convincing evidence that learning about geometric cues is governed by the principles of associative learning. Miller and ShettlewortiVs (2007) model however, failed to predict this outcome. Experiments 10-13 in Chapters 5 and 6 showed that associations formed between geometric and non-geometric cues. This outcome provides the basis for a viable explanation for potentiation and for the past failures to find cue competition in the spatial domain. The empirical findings of this thesis show that learning about geometric cues is not entirely void of associative processes as once thought. A number of recent models of spatial learning are discussed.
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Nutsford, Daniel. "An exploration of the associations between urban natural environments and indicators of mental and physical health." Thesis, University of Canterbury. Geography, 2014. http://hdl.handle.net/10092/9279.

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Natural environments, namely green and blue spaces, have been found to have positive influences on mental health outcomes globally. As the contribution of poor mental health to the disease burden increases, the mechanisms through which natural environments may improve health are of growing importance. This study creates a novel visibility index methodology and investigates whether i) views of natural environments and ii) access to natural environments, are associated with psychological stress and physical activity in Wellington, New Zealand. It also builds upon the work conducted in New Zealand as the first study to investigate links between blue space and mental health and provides an insight into the mechanisms through which increased natural environments may improve health. Individual level data for 442 individuals from the New Zealand Health Survey was obtained and Geographical Information Systems (GIS) were used to investigate whether area-level exposure to natural environments influenced their psychological stress and levels of physical activity. Results from regression analysis indicate that increased distant visible green space (beyond 3km), visible blue space, and a combination of green and blue spaces from neighbourhood centroids reduce psychological stress. Some access measures to natural environments were found to have positive associations with psychological stress, however increased proximal access to green space was associated with decreased physical activity. The findings conclude that the visibility of natural environments appears to have stronger associations with stress reduction than access to them. The findings of this paper should influence urban development and inform decision and policy making, particularly the development and/or relocation of health related facilities.
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Tribby, Calvin P. "Activity Spaces, Route Choices, and Neighborhoods: Assessing the Built Environment Associations with Walking Trips." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1459856961.

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Books on the topic "Environmental Association Analysis"

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Montana. Department of State Lands. Sapphire Village Permit Holders Association environmental assessment. Helena, Mont: Dept. of State Lands, 1993.

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Arctic Science Conference (43rd 1992 Valdez, Alaska). American Association for the Advancement of Science 43rd Arctic Science Conference, program and proceedings: Environmental change--natural and man-made, September 8-12, 1992, Valdez, Alaska. [Alaska]: Geophysical Institute, University of Alaska Fairbanks, 1992.

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Smith, Jeff P. Recommendations for improved raptor nest monitoring in association with oil and gas development activities. Salt Lake City, Utah: U.S. Department of the Interior, Bureau of Land Management, 2011.

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Consultants, Cobham Resource. An environmental assessment of fish farms: Final report to [the] Countryside Commission for Scotland, Crown Estate Commissioners, Highlands and Islands Development Board, Scottish Salmon Growers' Association. [S.l.]: [Countryside Commission for Scotland], 1987.

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Conference, International Association for Impact Assessment European Chapter. Impact forecasting and assessment: Methods, results, experiences : proceedings of the First Conference of the European Chapter of the International Association for Impact Assessment IAIA, Leiden and Delft, The Netherlands, June 16 and 17, 1988. Delft: Delft University Press, 1989.

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Weaver, Christopher S. Prospects for meeting low emission vehicle standards: A comparison of natural gas and reformulated gasoline : prepared for the Policy and Analysis Group, American Gas Association. Sacramento, Calif. (3050 Fite Circle, Suite 212, Sacramento 95827): Engine, Fuel, and Emissions Engineering, 1993.

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J, Barham Anthony, Macphail Richard, and University of London. Institute of Archaeology., eds. Archaeological sediments and soils: Analysis, interpretation and management : papers from the Tenth Anniversary Conference of the Association for Environmental Archaeology held at the Institute of Archaeology, UCL, July 1989. London: The Institute, 1995.

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Howards, Steven. Developing a company "action plan" for cleaning the air and expanding gas use at the state and local levels: A report to the Planning and Analysis Group of the American Gas Association. Arlington, Va. (1515 Wilson Blvd., Arlington 22209): The Association, 1991.

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European Association of Agricultural Economists. Seminar. Economic transition and the greening of policies: Modeling new challenges for agriculture and agribusiness in Europe : proceedins of the 50th European Seminar of the European Association of Agricultural Economists (EAAE) and the folow-up Conference of the European Short Course in Global Trade Analysis, October 15-17, 1996, Giessen, Germany. Kiel: Vauk, 1998.

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Office, General Accounting. Nuclear safety: Safety analysis reviews for DOE's defense facilities can be improved : report to the ranking minority member, Subcommittee on Energy, Nuclear Proliferation, and Government Processes, Committee on Governmental Affairs, United States Senate. Washington, D.C: The Office, 1986.

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Book chapters on the topic "Environmental Association Analysis"

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Dormann, Carsten. "Correlation and Association." In Environmental Data Analysis, 65–70. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-55020-2_5.

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Dormann, Carsten. "Correlation and Association in R." In Environmental Data Analysis, 71–80. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-55020-2_6.

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Sivanageswara Rao, G., U. Vignesh, Bhukya Jabber, T. Srinivasarao, and D. Babu Rao. "Survey on Biological Environmental Sequence Analysis Using Association Technique." In Advances in Intelligent Systems and Computing, 751–58. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-5400-1_71.

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Zhang, Chaobo, Yang Zhao, and Xuejun Zhang. "An Association Rule-Based Online Data Analysis Method for Improving Building Energy Efficiency." In Environmental Science and Engineering, 375–83. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-13-9524-6_40.

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Zhong, Shaobo, Min Xu, Chunxiang Cao, and Wei Zhu. "Variability Analysis of Local Climate Change and Its Association with Urbanization in the Beijing-Tianjin-Hebei Region, China." In Earth and Environmental Sciences Library, 521–40. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-12112-8_24.

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Zheng, Gang, Yaning Yang, Xiaofeng Zhu, and Robert C. Elston. "Gene-Environment Interactions." In Analysis of Genetic Association Studies, 287–308. Boston, MA: Springer US, 2012. http://dx.doi.org/10.1007/978-1-4614-2245-7_10.

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Warton, David I. "Multivariate Abundances—Inference About Environmental Associations." In Eco-Stats: Data Analysis in Ecology, 331–55. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-88443-7_14.

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Hughes, Neil, and José Mansilla. "Political discourse analysis of the degrowth challenge to dominant tourism narratives in Spain." In Issues and cases of degrowth in tourism, 86–103. Wallingford: CABI, 2021. http://dx.doi.org/10.1079/9781789245073.0005.

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Abstract This chapter uses as a case Spanish cities such as Madrid, Palma de Mallorca, Bilbao, Seville, Valencia and Barcelona, to explore the role that degrowth social movement actors and ideas have played in protest action directed at the tourism sector in recent years. The authors identify important episodes of contestation in which degrowth activists have been present. Particularly after 2015, the Neighbourhood Assembly for Sustainable Tourism, a degrowth-inspired association made up of grassroots organizations, assemblies and groups, has made several efforts to reduce the flow of tourists to Barcelona in an attempt to reverse the damaging social, economic, cultural and environmental effects that mass tourism is having on the city. In its attempt to explore various degrowth issues, the chapter sets out a conceptual framework that draws from key literature in the field of political discourse analysis, Althusserian treatment of ideology and interpellation, and work on degrowth and tourism.
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Hughes, Neil, and José Mansilla. "Political discourse analysis of the degrowth challenge to dominant tourism narratives in Spain." In Issues and cases of degrowth in tourism, 86–103. Wallingford: CABI, 2021. http://dx.doi.org/10.1079/9781789245073.0086.

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Abstract This chapter uses as a case Spanish cities such as Madrid, Palma de Mallorca, Bilbao, Seville, Valencia and Barcelona, to explore the role that degrowth social movement actors and ideas have played in protest action directed at the tourism sector in recent years. The authors identify important episodes of contestation in which degrowth activists have been present. Particularly after 2015, the Neighbourhood Assembly for Sustainable Tourism, a degrowth-inspired association made up of grassroots organizations, assemblies and groups, has made several efforts to reduce the flow of tourists to Barcelona in an attempt to reverse the damaging social, economic, cultural and environmental effects that mass tourism is having on the city. In its attempt to explore various degrowth issues, the chapter sets out a conceptual framework that draws from key literature in the field of political discourse analysis, Althusserian treatment of ideology and interpellation, and work on degrowth and tourism.
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Biancardi, Alberto, and Alain Mérigot. "Adding associative meshes to the PACCO I.P. environment." In Image Analysis and Processing, 109–16. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/3-540-63508-4_112.

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Conference papers on the topic "Environmental Association Analysis"

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Li, R. H., L. Carfi, Y. H. Lv, Y. S. Xia, C. Wu, Y. W. Yu, M. W. Qiu, W. C. Zhao, and P. G. Guo. "Association analysis of MFLP markers with bacterial wilt resistance in tobacco." In International Conference on Environmental Science and Biological Engineering. Southampton, UK: WIT Press, 2014. http://dx.doi.org/10.2495/esbe140381.

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Lingxia Guo, Zhang Bo, Yifei Zhao, and Xuqiang He. "Farmer's attitude to water user association participation management, based on gender analysis." In 2011 International Symposium on Water Resource and Environmental Protection (ISWREP). IEEE, 2011. http://dx.doi.org/10.1109/iswrep.2011.5893396.

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Weipeng Zhang and Aidi Huo. "Study on association of stroke and hemorheology based on factor & cluster analysis." In 2011 International Symposium on Water Resource and Environmental Protection (ISWREP). IEEE, 2011. http://dx.doi.org/10.1109/iswrep.2011.5893662.

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Mei, Li, Shan Yin, Wala Du, Yuhai Bao, and Shan Yu. "Evaluation of Eco-environmental Sensitivity in Xilingol Grassland." In 7th Annual Meeting of Risk Analysis Council of China Association for Disaster Prevention (RAC-2016). Paris, France: Atlantis Press, 2016. http://dx.doi.org/10.2991/rac-16.2016.37.

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Zhang, Qiaofeng, Guixiang Liu, Hongbo Yu, Shan Yu, and Yuhai Bao. "Spatiotemporal Characteristics Analysis of Environmental Sensitivity of Drought Disaster in Xilingol Grassland." In 8th Annual Meeting of Risk Analysis Council of China Association for Disaster Prevention (RAC 2018). Paris, France: Atlantis Press, 2018. http://dx.doi.org/10.2991/rac-18.2018.24.

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Andika, B. "Characteristics of Facies Associations, Ichnofacies and Microfossils for Depositional Environment Interpretation of The Clastic Pulau Balang Formation, Samarinda." In Digital Technical Conference. Indonesian Petroleum Association, 2020. http://dx.doi.org/10.29118/ipa20-sg-12.

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The Kutai Basin contains prolific reserves of oil and gas. The study of depositional environments is one of the goals of oil and gas exploration. The location of this research is situated in the Tanah Merah area, Samarinda. The objective of this research was to analyse outcrops of the Pulau Balang Formation exposed in the Tanah Merah area to determine the depositional environment. Site specific studies were conducted at 3 localities in this area; TM1, TM2 and TM3. This study combines geological mapping, measured sections, facies analysis, petrography, ichnofacies analysis and microfossil analysis. Geological mapping was carried out to determine the distribution of rock units and geological structures. Measured sections were used for facies analysis and the identification of sedimentary structures and ichnofacies. Petrography was carried out to determine the mineral content of rocks and microfossil analysis for palaeobathymetric environmental analysis. The geological structure of the study area comprises a NE-SW trending anticline and syncline and a left lateral strike-slip fault with E-W direction. The study area is entirely within the Middle Miocene age Pulau Balang Formation and can be divided into three facies associations. The TM1 facies association comprises strata interpreted to be deposited in a supratidal marsh and intertidal flat environment. The TM2 facies association comprises strata interpreted to be deposited in a subtidal, intertidal, and supratidal environment. The TM3 facies association comprises strata interpreted to be deposited in a shoreface environment. The petrography of the study area indicates that rock units predominantly comprise quartz wacke and lithic wacke. Two ichnofacies were identified in the research area 2, namely the Skolithos ichnofacies and the Skolithos-Cruziana ichnofacies and contain ichnogenera namely Ophiomorpha, Skolithos, Planolites, Thalassinoides, Paaleophycus. Microfossil analysis found benthonic foraminifera species including Nodosaria lamellala, N. radicula, Vaginulinopsis tricarinata, Lagena costata, Striatissima vaginulina, Bulimina lappa, Planularia auris, Quinqueloculina seminulum, Bolivina punctata and Lahena laevis. Based on the presence of these microfossils and ichnofacies, it is interpreted that the research area was deposited in a neritic-bathyal environment.
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Guo, S. F. "Analysis of the association between underdeveloped cities and regions based on self-development capabilities: the case study of Pingliang." In International Conference on Civil, Urban and Environmental Engineering. Southampton, UK: WIT Press, 2015. http://dx.doi.org/10.2495/cuee140791.

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Yarshevich, A. V., and P. M. Marozik. "ANALYSIS OF ASSOCIATION OF VDR GENE VARIANTS WITH SERUM VITAMIN D LEVEL IN PATIENTS WITH BONE-MUSCULAR DISEASE." In SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute of Belarusian State University, 2021. http://dx.doi.org/10.46646/sakh-2021-2-146-149.

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Currently, the pathology of the musculoskeletal system is considered in several multifactorial diseases, the pathogenesis of which is complex and is due to the interaction of environmental and endogenous factors. An important role in the progression of pathology is played by disorders in metabolism and a decrease in sensitivity to vitamin D. Studies of the past two decades have shown that the various biological actions of the active metabolite of vitamin D - 1,25-dihydroxy vitamin D (calcitriol) - are carried out by modulating the expression of genes that are mediated by interaction with the intracellular vitamin D receptor (VDR). VDR is a product of the corresponding gene - VDR, which determines its structure and functional activity. In this gene, a certain number of polymorphic variants have been identified that can affect gene expression.
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Ooi, D. "Comparative analysis of the relative attractiveness of the current fiscal terms in the South East Asia region." In Indonesian Petroleum Association 44th Annual Convention and Exhibition. Indonesian Petroleum Association, 2021. http://dx.doi.org/10.29118/ipa21-bc-205.

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This paper aims to assess the relative competitiveness of the current fiscal terms in South East Asia in the context of changes proposed and implemented across the region. A discounted cash flow (DCF) analysis was carried out based on the generic fiscal terms of Brunei, Indonesia, Malaysia, Thailand, and Vietnam based on an offshore, shallow water development. Where applicable, a comparison will be made against the previous fiscal terms of the country. Analysis will focus on investor returns and from the host government perspective evaluating net present value (NPV), internal rate of return (IRR), and government take. The fiscal terms were also assessed on whether they are progressive or regressive and provide an equitable return to both investors and host governments. Indonesia, Thailand, and Malaysia have seen recent shifts in their fiscal terms with new terms introduced in 2017, 2018, and 2021, respectively. Indonesia saw the introduction of the Gross Split Production Sharing Contract (GS PSC), which based on this analysis does not appear to be an improvement on the previous Cost Recovery Production Sharing Contract (CR PSC). Thailand saw the introduction of a CR PSC which was applied to the two expired offshore, producing, blocks. Based on our analysis, the newly introduced fiscal terms for Malaysia appears to provide a significant improvement to the previous terms and is likely to encourage further investment. Governments and regulators will face greater pressure to provide further incentives and greater flexibility to attract investments in the face of maturing fields, marginal fields, challenging sour gas resources, and capital constraints resulting from and Environmental, Social, and Corporate Governance (ESG) pressures on oil and gas companies.
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Abdullatif, Osman, Mutasim Osman, Mazin Bashri, Ammar Abdlmutalib, and Mohamed Yassin. "Sedimentology and Evolution of the Fluvial-Deltaic System: A Modern Depositional Model Analog from the Red Sea Coastal Region, Saudi Arabia." In SPE Middle East Oil & Gas Show and Conference. SPE, 2021. http://dx.doi.org/10.2118/204558-ms.

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Abstract Siliciclastic sediments represent important lithological unit of the Red Sea coastal plain. Their subsurface equivalents are important targets of groundwater aquifer and hydrocarbon reservoirs in the region. The lithofacies of the modern fluvial deltaic system has several distinct geomorphic units and sub-environments such as alluvial, fluvial, delta plain, aeolian, intertidal, coastal sabkha and eustuarine sediments. This study intends to characterize the lithofacies and the depositional environments and to produce an integrated facies model for this modern fluvial-deltaic system. The study might provide a valuable modern analog to several important subsurface Neogene formations that act as important hydrocarbon reservoirs and groundwater aquifers. The study integrates information and data obtained from landsats, maps and detailed field observation and measurements of facies analysis of the fluvial and deltaic along traveses from the Arabian Shield to the Red Sea coast. The lithofacies sediment analysis revealed four main lithofacies associations namely lithofacies A,B,C ad D. Lithoacies Associations A, which represents the oldest unit is dominated by coarse gravel with minor sands facies. While the lithofacies B is dominated byfine gravel and sand lithofacies, occasionally pebbly, vary from horizontal, planar to massive sands with minor laminated to massive silts and mud facies. The lithofacies in A and B show lateral proximal to distal variation as well as characteristic vertical stacking patterns. The Facies Association A and B indicates a change in fluvial depositional styles from gravelly alluvial fans to gravelly sandy fluvial systems. The lithofacies association C represents the recent fluvial system which consists of minor gravel lag deposits associated maily with various sand lithofacies of planner, horizontal and massive sand associated with massive and limainted sand and mud lithofacies. The lithofacies Association D is dominated with Barchan sand dunes local interfigger with muddy iinterdunes and sand sheets. Lithofacies D occupies rather more distal geomporphic position of the fluvial deltaic system that is adjace to coastal sabkha. The lithofacies associations described here document the evolution and development of the coastal plain sediments through space and time under various autocyclic and allocyclic controls. This included the tectonics and structural development associated with the Red Sea rifting and opening since the Oligocene – Miocene time. Others controls include the evolution of the Arabian shield (provenance) and the coastal plain through space and time as controlled by tectonics, sediment supply, climate and locally by autocyclic environmental This study might be beneficial for understanding the controls and stratigraphic evolution of the Red Sea region and will be of great value for reservoir and aquifer characterization, development and management. This modern analog model can also help in providing geological baseline information that would be beneficial for understanding similar ancient fluvial deltaic sediments. The study might provide guides and leads to understand the subsurface facies, stratigraphic architecture and heterogeneity of any potential groundwater aquifers and hydrocarbon reservoirs.
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Reports on the topic "Environmental Association Analysis"

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Ramm-Granberg, Tynan, F. Rocchio, Catharine Copass, Rachel Brunner, and Eric Nelsen. Revised vegetation classification for Mount Rainier, North Cascades, and Olympic national parks: Project summary report. National Park Service, February 2021. http://dx.doi.org/10.36967/nrr-2284511.

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Field crews recently collected more than 10 years of classification and mapping data in support of the North Coast and Cascades Inventory and Monitoring Network (NCCN) vegetation maps of Mount Rainier (MORA), Olympic (OLYM), and North Cascades (NOCA) National Parks. Synthesis and analysis of these 6000+ plots by Washington Natural Heritage Program (WNHP) and Institute for Natural Resources (INR) staff built on the foundation provided by the earlier classification work of Crawford et al. (2009). These analyses provided support for most of the provisional plant associations in Crawford et al. (2009), while also revealing previously undescribed vegetation types that were not represented in the United States National Vegetation Classification (USNVC). Both provisional and undescribed types have since been submitted to the USNVC by WNHP staff through a peer-reviewed process. NCCN plots were combined with statewide forest and wetland plot data from the US Forest Service (USFS) and other sources to create a comprehensive data set for Washington. Analyses incorporated Cluster Analysis, Nonmetric Multidimensional Scaling (NMS), Multi-Response Permutation Procedure (MRPP), and Indicator Species Analysis (ISA) to identify, vet, and describe USNVC group, alliance, and association distinctions. The resulting revised classification contains 321 plant associations in 99 alliances. A total of 54 upland associations were moved through the peer review process and are now part of the USNVC. Of those, 45 were provisional or preliminary types from Crawford et al. (2009), with 9 additional new associations that were originally identified by INR. WNHP also revised the concepts of 34 associations, wrote descriptions for 2 existing associations, eliminated/archived 2 associations, and created 4 new upland alliances. Finally, WNHP created 27 new wetland alliances and revised or clarified an additional 21 as part of this project (not all of those occur in the parks). This report and accompanying vegetation descriptions, keys and synoptic and environmental tables (all products available from the NPS Data Store project reference: https://irma.nps.gov/DataStore/Reference/Profile/2279907) present the fruit of these combined efforts: a comprehensive, up-to-date vegetation classification for the three major national parks of Washington State.
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Zhao, Yu, WenWen Bao, BoYi Yang, JingHong Liang, ZhaoHuan Gui, Shan Huang, YiCan Chen, GuangHui Dong, and YaJun Chen. Association between Greenspace and Blood Pressure: A Systematic Review and Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, October 2021. http://dx.doi.org/10.37766/inplasy2021.10.0033.

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Review question / Objective: Hypertension is a major risk factor for cardiovascular disease, which remains the leading cause of mortality worldwide. Urban environment as an possible cause of hypertension has received great attention. We aimed to systematically review the associations between greenspace and blood pressure (BP) levels/hypertension and use a meta-analysis to quantify the effects of greenspace on BP levels/hypertension. Condition being studied: Many epidemiological studies have assessed associations of greenspace with blood pressure levels and/or the prevalence of hypertension, whereas the results was inconsistent with some studies showing positive association but the others reporting null or negative associations. Systematic review and meta-analysis was conducted to synthesize data quantitatively across studies based on the primary outcome.
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Hernández, Beatriz. Modernising the EU-Chile Association Agreement: strengthening an alliance for social inclusion and environmental sustainability. Fundación Carolina, May 2022. http://dx.doi.org/10.33960/issn-e.1885-9119.dtff05en.

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This research paper analyzes the results of the Association Agreement (AA) between the European Union and Chile, which entered into force in 2003, up to the present time when its modernization is being negotiated. After 19 years of the agreement, the international context has changed both in its political and economic dimensions, so it is important to analyze what role these agreements can have in the face of the challenges of the post-pandemic recovery and the objectives of both regions in terms of strategic autonomy, in the geopolitical field, and in the transition towards new development models that respond to shared challenges such as climate change, ecological transition, digitalization, social inclusion or the revitalization of multilateralism.
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Hutchinson, M. L., J. E. L. Corry, and R. H. Madden. A review of the impact of food processing on antimicrobial-resistant bacteria in secondary processed meats and meat products. Food Standards Agency, October 2020. http://dx.doi.org/10.46756/sci.fsa.bxn990.

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For meat and meat products, secondary processes are those that relate to the downstream of the primary chilling of carcasses. Secondary processes include maturation chilling, deboning, portioning, mincing and other operations such as thermal processing (cooking) that create fresh meat, meat preparations and ready-to-eat meat products. This review systematically identified and summarised information relating to antimicrobial resistance (AMR) during the manufacture of secondary processed meatand meat products (SPMMP). Systematic searching of eight literature databases was undertaken and the resultantpapers were appraised for relevance to AMR and SPMMP. Consideration was made that the appraisal scores, undertaken by different reviewers, were consistent. Appraisal reduced the 11,000 initially identified documents to 74, which indicated that literature relating to AMR and SPMMP was not plentiful. A wide range of laboratory methods and breakpoint values (i.e. the concentration of antimicrobial used to assess sensitivity, tolerance or resistance) were used for the isolation of AMR bacteria.The identified papers provided evidence that AMR bacteria could be routinely isolated from SPMMP. There was no evidence that either confirmed or refuted that genetic materials capable of increasing AMR in non-AMR bacteria were present unprotected (i.e. outside of a cell or a capsid) in SPMMP. Statistical analyses were not straightforward because different authors used different laboratory methodologies.However, analyses using antibiotic organised into broadly-related groups indicated that Enterobacteriaceaeresistant to third generation cephalosporins might be an area of upcoming concern in SPMMP. The effective treatment of patients infected with Enterobacteriaceaeresistant to cephalosporins are a known clinical issue. No AMR associations with geography were observed and most of the publications identified tended to be from Europe and the far east.AMR Listeria monocytogenes and lactic acid bacteria could be tolerant to cleaning and disinfection in secondary processing environments. The basis of the tolerance could be genetic (e.g. efflux pumps) or environmental (e.g. biofilm growth). Persistent, plant resident, AMR L. monocytogenes were shown by one study to be the source of final product contamination. 4 AMR genes can be present in bacterial cultures used for the manufacture of fermented SPMMP. Furthermore, there was broad evidence that AMR loci could be transferred during meat fermentation, with refrigeration temperatures curtailing transfer rates. Given the potential for AMR transfer, it may be prudent to advise food business operators (FBOs) to use fermentation starter cultures that are AMR-free or not contained within easily mobilisable genetic elements. Thermal processing was seen to be the only secondary processing stage that served as a critical control point for numbers of AMR bacteria. There were significant linkages between some AMR genes in Salmonella. Quaternary ammonium compound (QAC) resistance genes were associated with copper, tetracycline and sulphonamide resistance by virtue of co-location on the same plasmid. No evidence was found that either supported or refuted that there was any association between AMR genes and genes that encoded an altered stress response or enhanced the survival of AMR bacteria exposed to harmful environmental conditions.
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Fridman, Eyal, and Eran Pichersky. Tomato Natural Insecticides: Elucidation of the Complex Pathway of Methylketone Biosynthesis. United States Department of Agriculture, December 2009. http://dx.doi.org/10.32747/2009.7696543.bard.

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Plant species synthesize a multitude of specialized compounds 10 help ward off pests. and these in turn may well serve as an alternative to synthetic pesticides to reduce environmental damage and health risks to humans. The general goal of this research was to perform a genetic and biochemical dissection of the natural-insecticides methylketone pathway that is specific to the glandular trichomes of the wild species of tomato, Solanumhabrochaites f. glabratum (accession PI126449). Previous study conducted by us have demonstrated that these compounds are synthesized de novo as a derivate pathway of the fatty acid biosynthesis, and that a key enzyme. designated MethylketoneSynthase 1 (MKS 1). catalyzes conversion of the intermediate B-ketoacyl- ACPs to the corresponding Cn-1 methylketones. The approach taken in this proposed project was to use an interspecific F2 population. derived from the cross between the cultivated lV182 and the wild species PIl26449. for three objectives: (i) Analyze the association between allelic status of candidate genes from the fatty acid biosynthesis pathway with the methylketone content in the leaves (ii) Perform bulk segregant analysis of genetic markers along the tomato genome for identifying genomic regions that harbor QTLs for 2TD content (iii) Apply differential gene expression analysis using the isolated glands of bulk segregant for identifying new genes that are involved in the pathway. The genetic mapping in the interspecific F2 population included app. 60 genetic markers, including the candidate genes from the FAS pathway and SSR markers spread evenly across the genome. This initial; screening identified 5 loci associated with MK content including the candidate genes MKS1, ACC and MaCoA:ACP trans. Interesting observation in this genetic analysis was the connection between shape and content of the glands, i.e. the globularity of the four cells, typical to the wild species. was associated with increased MK in the segregating population. In the next step of the research transcriptomic analysis of trichomes from high- and 10w-MK plants was conducted. This analysis identified a new gene, Methy1ketone synthase 2 (MKS2), whose protein product share sequence similarity to the thioesterase super family of hot-dog enzymes. Genetic analysis in the segregating population confirmed its association with MK content, as well as its overexpression in E. coli that led to formation of MK in the media. There are several conclusions drawn from this research project: (i) the genetic control of MK accumulation in the trichomes is composed of biochemical components in the FAS pathway and its vicinity (MKS 1 and MKS2). as well as genetic factors that mediate the morphology of these specialized cells. (ii) the biochemical pathway is now realized different from what was hypothesized before with MKS2 working upstream to I\1KS 1 and serves as the interface between primary (fatty acids) and secondary (MK) metabolism. We are currently testing the possible physical interactions between these two proteins in vitro after the genetic analysis showed clear epistatic interactions. (iii) the regulation of the pathway that lead to specialized metabolism in the wild species is largely mediated by transcription and one of the achievements of this project is that we were able to isolate and verify the specificity of the MKS1 promoter to the trichomes which allows manipulation of the pathways in these cells (currently in progress). The scientific implications of this research project is the advancement in our knowledge of hitherto unknown biochemical pathway in plants and new leads for studying a new family in plants (hot dog thioesterase). The agricultural and biotechnological implication are : (i) generation of new genetic markers that could assist in importing this pathway to cultivated tomato hence enhancing its natural resistance to insecticides, (ii) the discovery of MKS2 adds a new gene for genetic engineering of plants for making new fatty acid derived compounds. This could be assisted with the use of the isolated and verified MKS1 promoter. The results of this research were summarized to a manuscript that was published in Plant Physiology (cover paper). to a chapter in a proceeding book. and one patent was submitted in the US.
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Apte, M. G., and C. A. Erdmann. Associations of indoor carbon dioxide concentrations, VOCS, environmental susceptibilities with mucous membrane and lower respiratory sick building syndrome symptoms in the BASE study: Analyses of the 100 building dataset. Office of Scientific and Technical Information (OSTI), October 2002. http://dx.doi.org/10.2172/806126.

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Hulata, Gideon, Thomas D. Kocher, Micha Ron, and Eyal Seroussi. Molecular Mechanisms of Sex Determination in Cultured Tilapias. United States Department of Agriculture, October 2010. http://dx.doi.org/10.32747/2010.7697106.bard.

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Tilapias are among the most important aquaculture commodities worldwide. Commercial production of tilapia is based on monosex culture of males. Current methods for producing all-male fingerlings, including hormone treatments and genetic manipulations, are not entirely reliable, in part because of the genetic complexity of sex determination and sexual differentiation in tilapias. The goals of this project are to map QTL and identify genes regulating sex determination in commonly cultured tilapia species, in order to provide a rational basis for designing reliable genetic approaches for producing all-male fingerlings. The original objectives for this research were: 1) to identify the gene underlying the QTL on LG1 through positional cloning and gene expression analysis; 2) to fine map the QTL on LG 3 and 23; and 3) to characterize the patterns of dominance and epistasis among QTL alleles influencing sex determination. The brain aromatase gene Cyp19b, a possible candidate for the genetic or environmental SD, was mapped to LG7 using our F2 mapping population. This region has not been identified before as affecting SD in tilapias. The QTL affecting SD on LG 1 and 23 have been fine-mapped down to 1 and 4 cM, respectively, but the key regulators for SD have not been found yet. Nevertheless, a very strong association with gender was found on LG23 for marker UNH898. Allele 276 was found almost exclusively in males, and we hypothesized that this allele is a male-associated allele (MAA). Mating of males homozygous for MAA with normal females is underway for production of all-male populations. The first progeny reaching size allowing accurate sexing had 43 males and no females. During the course of the project it became apparent that in order to achieve those objectives there is a need to develop genomic infrastructures that were lacking. Efforts have been devoted to the development of genomic resources: a database consisting of nearly 117k ESTs representing 16 tissues from tilapia were obtained; a web tool based on the RepeatMasker software was designed to assist tilapia genomics; collaboration has been established with a sequencing company to sequence the tilapia genome; steps have been taken toward constructing a microarray to enable comparative analysis of the entire transcriptome that is required in order to detect genes that are differentially expressed between genders in early developmental stages. Genomic resources developed will be invaluable for studies of cichlid physiology, evolution and development, and will hopefully lead to identification of the key regulators of SD. Thus, they will have both scientific and agricultural implications in the coming years.
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Fait, Aaron, Grant Cramer, and Avichai Perl. Towards improved grape nutrition and defense: The regulation of stilbene metabolism under drought. United States Department of Agriculture, May 2014. http://dx.doi.org/10.32747/2014.7594398.bard.

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The goals of the present research proposal were to elucidate the physiological and molecular basis of the regulation of stilbene metabolism in grape, against the background of (i) grape metabolic network behavior in response to drought and of (ii) varietal diversity. The specific objectives included the study of the physiology of the response of different grape cultivars to continuous WD; the characterization of the differences and commonalities of gene network topology associated with WD in berry skin across varieties; the study of the metabolic response of developing berries to continuous WD with specific attention to the stilbene compounds; the integration analysis of the omics data generated; the study of isolated drought-associated stress factors on the regulation of stilbene biosynthesis in plantaand in vitro. Background to the topic Grape quality has a complex relationship with water input. Regulated water deficit (WD) is known to improve wine grapes by reducing the vine growth (without affecting fruit yield) and boosting sugar content (Keller et al. 2008). On the other hand, irregular rainfall during the summer can lead to drought-associated damage of fruit developmental process and alter fruit metabolism (Downey et al., 2006; Tarara et al., 2008; Chalmers et al., 792). In areas undergoing desertification, WD is associated with high temperatures. This WD/high temperature synergism can limit the areas of grape cultivation and can damage yields and fruit quality. Grapes and wine are the major source of stilbenes in human nutrition, and multiple stilbene-derived compounds, including isomers, polymers and glycosylated forms, have also been characterized in grapes (Jeandet et al., 2002; Halls and Yu, 2008). Heterologous expression of stilbenesynthase (STS) in a variety of plants has led to an enhanced resistance to pathogens, but in others the association has not been proven (Kobayashi et al., 2000; Soleas et al., 1995). Tomato transgenic plants harboring a grape STS had increased levels of resveratrol, ascorbate, and glutathione at the expense of the anthocyanin pathways (Giovinazzo et al. 2005), further emphasizing the intermingled relation among secondary metabolic pathways. Stilbenes are are induced in green and fleshy parts of the berries by biotic and abiotic elicitors (Chong et al., 2009). As is the case for other classes of secondary metabolites, the biosynthesis of stilbenes is not very well understood, but it is known to be under tight spatial and temporal control, which limits the availability of these compounds from plant sources. Only very few studies have attempted to analyze the effects of different environmental components on stilbene accumulation (Jeandet et al., 1995; Martinez-Ortega et al., 2000). Targeted analyses have generally shown higher levels of resveratrol in the grape skin (induced), in seeded varieties, in varieties of wine grapes, and in dark-skinned varieties (Gatto et al., 2008; summarized by Bavaresco et al., 2009). Yet, the effect of the grape variety and the rootstock on stilbene metabolism has not yet been thoroughly investigated (Bavaresco et al., 2009). The study identified a link between vine hydraulic behavior and physiology of stress with the leaf metabolism, which the PIs believe can eventually lead to the modifications identified in the developing berries that interested the polyphenol metabolism and its regulation during development and under stress. Implications are discussed below.
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9

Mizrahi, Itzhak, and Bryan A. White. Uncovering rumen microbiome components shaping feed efficiency in dairy cows. United States Department of Agriculture, January 2015. http://dx.doi.org/10.32747/2015.7600020.bard.

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Ruminants provide human society with high quality food from non-human-edible resources, but their emissions negatively impact the environment via greenhouse gas production. The rumen and its resident microorganisms dictate both processes. The overall goal of this project was to determine whether a causal relationship exists between the rumen microbiome and the host animal's physiology, and if so, to isolate and examine the specific determinants that enable this causality. To this end, we divided the project into three specific parts: (1) determining the feed efficiency of 200 milking cows, (2) determining whether the feed- efficiency phenotype can be transferred by transplantation and (3) isolating and examining microbial consortia that can affect the feed-efficiency phenotype by their transplantation into germ-free ruminants. We finally included 1000 dairy cow metadata in our study that revealed a global core microbiome present in the rumen whose composition and abundance predicted many of the cows’ production phenotypes, including methane emission. Certain members of the core microbiome are heritable and have strong associations to cardinal rumen metabolites and fermentation products that govern the efficiency of milk production. These heritable core microbes therefore present primary targets for rumen manipulation towards sustainable and environmentally friendly agriculture. We then went beyond examining the metagenomic content, and asked whether microbes behave differently with relation to the host efficiency state. We sampled twelve animals with two extreme efficiency phenotypes, high efficiency and low efficiency where the first represents animals that maximize energy utilization from their feed whilst the later represents animals with very low utilization of the energy from their feed. Our analysis revealed differences in two host efficiency states in terms of the microbial expression profiles both with regards to protein identities and quantities. Another aim of the proposal was the cultivation of undescribed rumen microorganisms is one of the most important tasks in rumen microbiology. Our findings from phylogenetic analysis of cultured OTUs on the lower branches of the phylogenetic tree suggest that multifactorial traits govern cultivability. Interestingly, most of the cultured OTUs belonged to the rare rumen biosphere. These cultured OTUs could not be detected in the rumen microbiome, even when we surveyed it across 38 rumen microbiome samples. These findings add another unique dimension to the complexity of the rumen microbiome and suggest that a large number of different organisms can be cultured in a single cultivation effort. In the context of the grant, the establishment of ruminant germ-free facility was possible and preliminary experiments were successful, which open up the way for direct applications of the new concepts discovered here, prior to the larger scale implementation at the agricultural level.
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