Journal articles on the topic 'Engle (C.H.) (Publisher)'

BackgroundThe clinical success of PD-1- and CTLA-4- immune checkpoint inhibitors highlights the key contribution of immunosuppression to limiting effective anti-tumor responses. However, as many patients do not respond to anti-PD1 or CTLA4 therapy1-3 novel therapeutics that target additional immune-suppressive mechanisms are needed. Regulatory T cells (Tregs) inhibit immune responses in the tumor microenvironment via multiple suppressive mechanisms.4 5 Existing Treg-targeting agents lack specificity for intratumoral Tregs and can also deplete effector cells, a property that has likely contributed to the lack of clinical activity observed to date. CCR8 (C-C chemokine receptor 8) is selectively expressed on highly activated intratumoral Tregs, its high expression correlates with poor prognosis in multiple human tumor types6 7 and depletion of CCR8+ Tregs in preclinical models elicited potent anti-tumor activity. These observations provided rationale for the development of a CCR8-specific human depleting antibody.MethodsHuman FOXP3 and CCR8 expression was correlated across multiple tumor types using TCGA datasets and expression of CCR8 evaluated in primary tumor explants and PBMCs by flow cytometry. The efficacy of anti-CCR8 antibody treatment was evaluated in the MC38 and CT26 murine tumor models. The depletion of Tregs following anti-CCR8 treatment was assessed by flow cytometry. Flow cytometric-based binding assays were performed using cell lines expressing human or cynomolgus CCR8. Purified human NK cells were co-cultured with CCR8+ target cells and flow cytometry used to evaluate antibody-dependent killing activity.ResultsCCR8 expression was highly correlated with FoxP3 across multiple cancer subtypes and was low to absent on effector T cells. Importantly, CCR8 was not detected on any peripheral human leukocyte subset. In murine tumor models, anti-CCR8 antibody treatment reduced tumor growth in a dose- and Fc-gamma-receptor-dependent manner and resulted in complete regressions and the development of memory. Tumor shrinkage was associated with a reduction in intratumoral Tregs and increased representation of intratumoral CD8 T cells. FPA157 is a highly specific human and cynomolgus crossreactive CCR8 antibody that does not bind closely related chemokine receptors. FPA157 was engineered to enhance antibody-dependent cell-mediated cytotoxicity (eADCC) and elicited potent NK-mediated killing of target cells expressing CCR8 at levels observed on human intratumoralTregs.ConclusionsFPA157 is a CCR8-specific monoclonal antibody with eADCC activity that is being developed for the treatment of cancer. Depletion of CCR8+ Tregs induced substantial anti-tumor activity in pre-clinical models, thus supporting the clinical evaluation of FPA157 as a novel approach to alleviate immune suppression in the microenvironment of human solid tumors.ReferencesHellmann MD, Ciuleanu TE, Pluzanski A, Lee JS, Otterson GA, Audigier-Valette C, Minenza E, Linardou H, Burgers S, Salman P, Borghaei H, Ramalingam SS, Brahmer J, Reck M, O’Byrne KJ, Geese WJ, Green G, Chang H, Szustakowski J, Bhagavatheeswaran P, Healey D, Fu Y, Nathan F, Paz-Ares L. Nivolumab plus Ipilimumab in lung cancer with a high tumor mutational burden. N Engl J Med 2018;378(22):2093-2104.Wolchok JD, Chiarion-Sileni V, Gonzalez R, Rutkowski P, Grob JJ, Cowey CL, Lao CD, Wagstaff J, Schadendorf D, Ferrucci PF, Smylie M, Dummer R, Hill A, Hogg D, Haanen J, Carlino MS, Bechter O, Maio M, Marquez-Rodas I, Guidoboni M, McArthur G, Lebbé C, Ascierto PA, Long GV, Cebon J, Sosman J, Postow MA, Callahan MK, Walker D, Rollin L, Bhore R, Hodi FS, Larkin J. Overall survival with combined nivolumab and ipilimumab in advanced melanoma. N Engl J Med 2017;377(14):1345-1356.Motzer RJ, Tannir NM, McDermott DF, Arén Frontera O, Melichar B, Choueiri TK, Plimack ER, Barthélémy P, Porta C, George S, Powles T, Donskov F, Neiman V, Kollmannsberger CK, Salman P, Gurney H, Hawkins R, Ravaud A, Grimm MO, Bracarda S, Barrios CH, Tomita Y, Castellano D, Rini BI, Chen AC, Mekan S, McHenry MB, Wind-Rotolo M, Doan J, Sharma P, Hammers HJ, Escudier B; CheckMate 214 Investigators. Nivolumab plus ipilimumab versus sunitinib in advanced renal-cell carcinoma. N Engl J Med 2018 Apr 5;378(14):1277-1290.Teng MW, Ngiow SF, von Scheidt B, McLaughlin N, Sparwasser T, Smyth MJ. Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth [published correction appears in Cancer Res. 2010; 70(23):10014]. Cancer Res 2010;70(20):7800-7809.Simpson TR, Li F, Montalvo-Ortiz W, Sepulveda MA, Bergerhoff K, Arce F, Roddie C, Henry JY, Yagita H, Wolchok JD, Peggs KS, Ravetch JV, Allison JP, Quezada SA. Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma. J Exp Med 2013;210(9):1695-710.Plitas G, Konopacki C, Wu K, Bos PD, Morrow M, Putintseva EV, Chudakov DM, Rudensky AY. Regulatory T cells exhibit distinct features in human breast cancer. Immunity 2016;45(5):1122-1134.De Simone M, Arrigoni A, Rossetti G, Gruarin P, Ranzani V, Politano C, Bonnal RJP, Provasi E, Sarnicola ML, Panzeri I, Moro M, Crosti M, Mazzara S, Vaira V, Bosari S, Palleschi A, Santambrogio L, Bovo G, Zucchini N, Totis M, Gianotti L, Cesana G, Perego RA, Maroni N, Pisani Ceretti A, Opocher E, De Francesco R, Geginat J, Stunnenberg HG, Abrignani S, Pagani M. Transcriptional landscape of human tissue lymphocytes unveils uniqueness of tumor-infiltrating T regulatory cells. Immunity 2016;45(5):1135-1147.

In the framework of new materials and next-generation batteries, the acceleration and quantification of the improvements that these advances pose, have become a priority in the field. In this regard, rate performance sits in an interesting spot. It is gaining more and more importance due to the electrification of transportation but its quantitative analysis is usually overlooked. In this regard, recently, new methodologies have been developed to allow the quantification of the rate performance. [1] It has been shown that the parameters used for this quantification, can be linked to intrinsic properties of the electrodes and materials, becoming a tool to further improve their understanding and optimization.[2] However, the usefulness of this methodology is damped by the slow acquisition of the rate data by galvanostatic cycling, which at very low rates can take even weeks. This limitation leads to reduced data density hampering the building of solid statistics to feed models. To mitigate this problem, chronoamperometry has been proposed as an accelerated method to acquire rate-performance data.[3] It has been proved that the low current/rate section of the chronoamperometry indeed matches the data of the galvanostatic equivalent, and it has been used as a way to characterize materials and electrodes.[4, 5] However, the high current/rate section has proved much more challenging, showing inconsistent results across references and a not well-understood dependence on materials that manifest as another contribution that difficult the data interpretation. [6] In this work, we focus on the high-rate behavior of the chronoamperometric response of the electrodes. We show how this abnormal contribution can distort the fitting of the capacity-rate curves highly affecting the quantification of the rate performance parameters. To avoid this distortion, we have investigated the origin of the contribution by electrochemical impedance spectroscopy and simulations, and developed a methodology to isolate and mitigate it. This leads to more reliable datasets that permit very accurate fittings that match the galvanostatic data and works for all the common LIBs materials tested.[7] These advances will surely boost the usefulness and reliability of the technique as a way to characterize batteries. (1) Heubner, C.; L¨ammel, C.; Nickol, A.; Liebmann, T.; Schneider, M.; Michaelis, A. Journal of Power Sources 2018, 397, Publisher: Elsevier, 11–15. (2) Tian, R.; Park, S.-H. H.; King, P. J.; Cunningham, G.; Coelho, J.; Nicolosi, V.; Coleman, J. N. Nature Communications 2019, 10, Publisher: Nature Publishing Group, 1933. (3) Heubner, C.; Seeba, J.; Liebmann, T.; Nickol, A.; B¨ orner, S.; Fritsch, M.; Nikolowski, K.; Wolter, M.; Schneider, M.; Michaelis, A. Journal of Power Sources 2018, 380, 83–91. (4) Pinilla, S.; Ryan, S.; McKeon, L.; Lian, M.; Vaesen, S.; Roy, A.; Schmitt, W.; Coleman, J. N.; Nicolosi, V. Advanced Energy Materials 2023, 2203747. (5) Tian, R.; Alcala, N.; O’Neill, S. J.; Horvath, D.; Coelho, J.; Griffin, A.; Zhang, Y.; Nicolosi, V.; O’Dwyer, C.; Coleman, J. N. ACS Applied Energy Materials 2020, DOI: 10.1021/acsaem. 0c00034. (6) Tian, R.; King, P. J.; Coelho, J.; Park, S. H.; Horvath, D. V.; Nicolosi, V.; O’Dwyer, C.; Coleman, J. N. Journal of Power Sources 2020, 468, DOI: 10.1016/j.jpowsour.2020.228220. (7) Manuscript under preparation.

Abstract In a subset of patients suffering from myeloproliferative neoplasms (MPNs), calreticulin (CALR) exon 9 frameshift mutations are known to be responsible for the development of either essential thrombocythemia (ET) or primary myelofibrosis (PMF) (1, 2). The most prevalent mutations are a 52-bp deletion (del52, type-1 mutation) and a 5-bp TTGTC insertion (ins5, type-2 mutation). In these patients, the mutational status is almost always heterozygous. Our group and collaborators have recently shown that the pathogenic mutant CALR proteins require interaction with and activation of the thrombopoietin receptor (TpoR) for activation of the JAK-STAT pathway (3, 4). Until now, no knock-in mouse model of these diseases has been published. In this abstract, we show how we succeeded in creating such a model. We had shown that the murine CALR mutant proteins behave just like their human counterparts (5). Specifically, the del52, ins5 and del61 (61bp deletion, type-1) Calr mutations were able to transform Ba/F3 cells (murine pro-B lymphocytic cells normally dependent on IL-3 for growth) expressing the thrombopoietin receptor (TpoR) and render them cytokine-independent. Importantly, we also mutated the Ba/F3 genome using the widely adopted CRISPR/Cas9 system in order to create a 61-bp deletion of the exon 9 of Calr. This too successfully transformed the Ba/F3 cells, showing that endogenous levels of expression of a mutant CALR protein are sufficient to induce phenotype in vitro. Now, using the same approach, we injected C57BL/6J mouse zygotes with the same CRISPR/Cas9 constructs to create the same 61-bp deletion in the murine Calr gene. Out of 46 pups born from the procedure, one male pup was heterozygous for the 61-bp deletion. By in vitro fertilization, we subsequently obtained heterozygous Calr del61/WT pups. After inter-breeding the mice, we analyzed the blood of 12 Calr del61/WT males and 12 Calr WT/WT males (littermates) at three different timepoints (15, 18 and 22 weeks old) and found that the Calr del61/WT mice showed significantly higher levels of circulating platelets. Conversely, red blood and white blood cell numbers were the same between both groups at all time points. We further show that expression of a mutant CALR protein, in a heterozygous state, is sufficient to induce abnormal proliferation of megakaryocytes and develop an ET phenotype in vivo in mice. Follow-up in dynamics of the phenotype and bone marrow and spleen pathology (examination of myeloproliferation and fibrosis) allow comparison with the retroviral murine models of CALR-mutant MPNs and with the known features of the human disease. The only limitation of our model is the fact that the Calr del61 mutation is parentally acquired and widespread throughout the organism. With this new model, we aim to test the efficiency of various drugs to prevent or cure the MPN phenotype, such as ruxolitinib, a JAK2 type-1 inhibitor that is already used in clinics in patients suffering from CALR-mutated MPNs. We also now have a means to generate a high number of Calr del61/WT bone marrow cells to extensively study the oncogenic properties of the Calr mutations at different stages of the hematopoeisis. It will also be of great interest to study, if generated, a homozygous mutational status of Calr del61 in vivo. Thus, our system will shed light on the importance of the negatively charged tail of CALR and on the effects of the novel positively charged tail on myeloproliferation. References 1. Klampfl T, Gisslinger H, Harutyunyan AS, Nivarthi H, Rumi E, Milosevic JD, et al. N Engl J Med. 2013 Dec 10;369(25):2379-90. 2. Nangalia J, Massie CE, Baxter EJ, Nice FL, Gundem G, Wedge DC, et al. N Engl J Med. 2013 Dec 10;369(25):2391-405. 3. Chachoua I, Pecquet C, El-Khoury M, Nivarthi H, Albu RI, Marty C, et al. Blood. 2015 Dec 14;10.1182/blood-2015-11-681932. 4. Marty C, Pecquet C, Nivarthi H, Elkhoury M, Chachoua I, Tulliez M, et al. Blood. 2015 Nov 25;10.1182/blood-2015-11-679571. 5. Balligand T, Achouri Y, Pecquet C, Chachoua I, Nivarthi H, Marty C, et al. Leukemia. 2016 Feb 29;10.1038/leu.2016.47. Disclosures Constantinescu: Teva: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Novartis: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Shire: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Personal Genetics: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau.

BackgroundThe randomized controlled trial (RCT) remains a most important research as well as a tool for drug licensing. Informed consent also remains an integral component of this tool. The exact wording of this consent is not in the public domain and we had previously raised that concern and had pointed out it should [1, 2]. As we previously indicated such transparency was important from the point of an organized skepticism an essential element of scientific inquiry [3]. Moreover, we had also indicated that this transparency was even more important in safety outcome trials (SOT)s. We have the impression that such SOTs are becoming more frequent especially with the increasing popularity of pragmatic trials [4] where the safety outcome measures are not infrequently as severe as death.ObjectivesTo tabulate the frequency of RCTs with the primary outcome measure of safety in mainline general medicine journals at two time points, thirty years apart.MethodsRCTs published in 1990-1991 vs 2019-2020 in NEJM, JAMA, LANCET and BMJ were searched by 2 independent reviewers (AO and SNE). Phase 1-2 RCTs, post-hoc analyses of RCTs and RCTs reporting long term follow-up data were excluded. RCTs with an undisputable primary endpoint of efficacy were defined as an ‘A trial’. Those trials with declared or obvious primary endpoints of ‘safety’, ‘efficacy and safety’ or simply as ‘efficacy’ in which we unanimously considered the presence of serious harm to the patients in the control arms were defined as a ‘B trial’. Finally, the trials that we could not unanimously decide whether designate A or B, were designated as C. Discrepancies were resolved after discussion with the senior author (HY) and if, even then, there was no consensus the trial remained as a C. We then compared the frequencies of the types of RCTs which were published in 1990-1991 vs 2019-2020. Other salient features, like the type and the practice setting, of these patients were also tabulated.ResultsThere were 309 RCTs published in 1990-1991 and 600 RCTs published in 2019-2020. Nineteen RCTs on COVID-19 infection were excluded for fair comparisons. As seen in the Table 1 there was a significant increase in the number SOTs in the later years. Moreover, the number of intensive care unit (ICU) trials, a setting in which obtaining informed consents can often be problematic, significantly increased.ConclusionRecently, there is a significant increase in the number of SOTs. Moreover, they are more frequently conducted in the ICUs. We strongly re-emphasize that the informed consents of all RCTs, particularly, those related to SOTs should be public. We strongly consider that such action is necessary a. to continue receiving our patients’ vital consent to enable us to continue conducting RCTs and b. for justly addressing the organized skepticism of our peers.References[1] Yazici Y, Yazici H. Informed consent: time for more transparency. Arthritis Res Ther 2010;12: 121.[2] Ozdede A, Yazici H. Cardiovascular and Cancer Risk with Tofacitinib in Rheumatoid Arthritis. N Engl J Med 2022; 386(18):1766.[3] Merton, Robert K. Science and technology in a democratic order. Journal of Legal and Political Sociology 1942; 1:115–126.[4] Patsopoulos NA. A pragmatic view on pragmatic trials. Dialogues Clin Neurosci 2011; 13:217-24.Table 1.1990-1991 (n=309)2019-2020 (n=581)OR (95% CI)Total number of RCTs309581A trial284 (91.9%)501 (86.2%)0.6 (0.3-1.0)B trial9 (2.9%)39 (6.7%)2.4 (1.1-5.0)None-A trial*25 (8.1%)80 (13.8%)2.0 (1.1-2.1)ICU trial12 (3.8%)52 (8.9%)2.4 (1.3-4.6)* All non-A trials include trials designated B and C.Acknowledgements:NIL.Disclosure of InterestsNone Declared.

Setiap karya sastra mengandung nilai-nilai yang bersumber dari agama, tradisi, budaya, dan kebangsaan. Karya sastra berkaitan erat dengan pendidikan karakter. Karya sastra merupakan sarana yang efektif untuk memberikan nilai-nilai pendidikan karakter. Dalam hal ini penelitian anak meneliti karya sastra dalam kumpulan cerpen. Tujuan Penelitian berupa: (1) mendeskripsikan karakter religius yang terkandung dalam kumpulan Cerita Anak Banua, (2) mendeskripsikan karakter nasionalis yang terkandung dalam kumpulan Cerita Anak Banua, (3) mendeskripsikan karakter integritas yang terkandung dalam kumpulan Cerita Anak Banua. (4) mendeskripsikan karakter mandiri yang terkandung dalam kumpulan Cerita Anak Banua, dan (5) mendeskripsikan karakter gotong royong yang terkandung dalam kumpulan Cerita Anak Banua. Pendekatan yang digunakan adalah penndekatan sosiologis dengan jenis penelitian kepustakaan. Metode yang digunakan adalah metode analisis isi dengan sumber data berupa kumpulan Cerita Anak Banua. Diterbitkan oleh Zahra Publisher Grub, Kota Malang, Jawa Timur, pada tahun 2020. Adapun cerita yang diambil peneliti berjumlah 12 judul cerita. Peneliti menggunakan teknik pengumpulan data pustaka, baca, dan teknik catat. Teknik deskriptif analisis merupakan Teknik analisis data yang digunakan. Hasil penelitian diperoleh bahwa: (1) Karakter Religius berjumlah 16 kutipan, yang terdapat dalam 5 cerita sebagai berikut: (a) Oleh-oleh Acil, (b) Bedak Dingin Laila, (c) Julak Kaning dan Sarakap Ajaib, (d) Udin Si Monyet dan Jamal Si Bekantan, dan (e) Kelekai Ajaib. (2) Karakter Nasionalis berjumlah 5 kutipan, yang terdapat dalam 3 cerita antara lain: (a) Julak Kaning dan Sarakap Ajaib, (b) Sunatan, dan (c) Unta Kertas. (3) Karakter Integritas berjumlah 20 kutipan, yang terdapat dalam 9 cerita sebagai berikut: (a) Mandai Untuk Dayu, (b) Oleh-oleh Acil, (c) Bedak Dingin Laila, (d) Julak Kaning dan Sarakap Ajaib, (e) Raja Bakung dan Putri Salsa, (f) Cici dan Hujan, (g) Unta Kertas, (h) Lempeng Pisang, dan (i) Kelekai Ajaib. (4) Karakter Mandiri berjumlah 6 kutipan, yang terdapat dalam 5 cerita yaitu: (a) Mandai Untuk Dayu, (b) Oleh-oleh Acil, (c) Bedak Dingin Laila, (d) Raja Bakung dan Putri Salsa, dan (e) Si Ringsang. (5) Karakter Gotong Royong berjumlah 53 kutipan, yang terdapat dalam 12 cerita sebagai berikut: (a) Mandai Untuk Dayu, (b) Oleh-oleh Acil, (c) Bedak Dingin Laila, (d) Julak Kaning dan Sarakap Ajaib, (e) Sunatan, (f) Udin Si Monyet dan Jamal Si Bekantan, (g) Raja Bakung dan Putri Salsa, (h) Si Ringsang, (i) Cici dan Hujan, (j) Unta Kertas, (k) Lempeng Pisang, dan (l) Kelekai Ajaib. Kata Kunci: nilai karakter, cerita anak

Charlotte Appel: Titles, typography and other adjustments. A study of Morten Hallager as a media-savvy publisher of Danish books for children during the last decades of the eighteenth century This article investigates the involvement of Morten Hallager (1740–1803) in the book business, and how he contributed to shaping a new commodity in Denmark: books for children. Until recently, Hallager has not attracted much scholarly attention due to a traditional focus on authors who made original contributions to Danish literature. However, Hallager’s combined experience as a printer (1771–84), a schoolteacher (from 1785) and an expert in German and French gave him a unique background to act as a transnational agent, introducing European Enlightenment literature for children (by J. H. Campe, C. K. J. Dassel, K. T. Thieme, A. Berquin etc.) to Danish readers. After an outline of Hallager’s life and career, the article presents a survey of his publications. He was particularly active as an author, translator, compiler and publisher of books for children c.1791–1804 (his last books were published posthumously), and during this period he published 38 individual titles – and 57 editions in all (including 19 second or later editions) – corresponding to c.11 per cent of all Danish titles for a young readership. Four main types of intervention that characterise Hallager’s books for children are analysed. First, he took great care over titles and the contents of title pages. Most of them would include an explicit reference to ‘child’, ‘children’ or ‘youth’, and Hallager would present himself as a schoolteacher and thus an expert in the field. Next, when it came to the physical appearance of the books, Hallager made use of his professional know-how. His initial success, a small reader in sextodecimo from 1791 (reprinted ten times), for example, demonstrated how he made choices concerning format, typeface etc. Third, Hallager made a number of pedagogical adjustments to the translated texts, reflecting his ambition to be as specific and concrete as possible and also to include variety, so that his young readers were never bored. Fourth, the article maps his impressive range of strategies with regard to translating, transforming and ‘localising’ foreign texts, so that they would become more digestible and relevant for a Danish audience. Finally, the conclusion argues that Hallager’s experience in every role and every position within Robert Darnton’s famous communication circuit (1982) was a key to his success – and may explain his wish to explicate his publishing strategies in great detail. For this reason, a study of Hallager’s publications provides us with new insights not only into his own book business but also into the emerging market for children’s books in general.

Includes the following reviews:pp. 96-97. Sandra Freeman. Griffiths, T.R. & Llewellyn, M. (eds.), British and Irish Women Dramatists Since 1958. pp. 97-98. Michael Jamieson. Esslin, M., Pinter the Playwright. pp. 98-100. Christopher Murray. Hodgson, T., Modern Drama: From Ibsen to Fugard. + Innes, C., Modern British Drama 1890-1990. pp. 100-103. Ulf Danatus. Russell, J.R., The Penguin Dictionary of the Theatre. + Wandor, M., Drama Today; A Critical Guide to British Drama. + Acheson, J. (ed.), British and Irish Drama since 1960. + Hilton, J. (ed.), New Directions in Theatre. pp. 103-105. Göran Kjellmer. Cowie, A.P. & Mackin, R. (eds.), Oxford Dictionary of Phrasal Verbs. p. 105. Anne Moskow. Virago Press - Feminist Publisher. pp. 105-106. Ronald Paul. Burgess, A., A Mouthful of Air. pp. 106-109. Frank-Michael Kirsch. Byram, M. (ed.), Germany. Its Representation in Text, Books for Teaching German in Great Britain. pp. 110-111. Bo Andersson. Günter, S. & Kotthoff, H. (Hrsg.), Die Geschlechter im Gespräch. Kommunikation in Institutionen. pp. 112-113. Gustav Korlén. Leiser, E., Gott hat kein Kleingeld. pp. 114-117. Elisabeth Tegelberg. L'année scandinave 1989-1991, Nouvelles du Nord 1992. pp. 117-118. Börje Schylter. Hedberg, J., Nostalgia. pp. 118-119. Lars-Göran Sundell. Boysen, G., Fransk grammatik. p. 120. Redaktionsmeddelande/A Message from the Editors

<p>This is a descriptive qualitative research that uses a psychological approach. The data source of this research is the novel The Invention of Hugo Cabret by Brian Selznick, publisher of Scholastic Press, New York (original version) in 2007, Mizan Fantasi (Indonesian version) in 2012. The research data are in the form of words, phrases and sentences that related with the main character's motives and the character education values in the novel. Data obtained by reading and note taking techniques. This objective of this study to analyze the existence of the main character's action motives and the value of character education in the novel The Invention of Hugo Cabret by Brian Selznick. The results of the analysis obtained the following conclusions: 1. Hugo's motives as the main character there are 20 quotes, namely as follows: a) motives for physical needs there are 3 quotations, b) motives for security and safety needs are 4 quotations, c) motives for trust and compassion consist from 5 quotations, d) the motive for self-esteem needs there are 3 quotations, e). The motives for self-actualization needs are 6 quotations. The prominent action motive is the motive for self-actualization needs. 2. The value of character education contained in Brian's novel The Invention of Hugo Cabret, consisting of; a) religious 2 quotes, b) honest 4 quotes, c) discipline 3 quotes, d) hard work 7 quotes, e) creative 2 quotes, f) independent 1 quote, g) curiosity 4 quotes, h) appreciate achievement 2 quotes, i) friends 3 quotes, j) peace love 1 quote, k) likes to read 2 quotes, l) social care 4 quotes, m) responsibility 2 quotes.</p>

The results of spectroscopic (magneto-transmission and Raman scattering) studies1–8 of multilayers of carbon which are thermally decomposed from carbon-terminated surface of silicon carbide, and of thin layers of highly oriented pyrolytic and natural graphite were presented. Those carbon multilayers on silicon carbide which are not directly affected by the SiC / C interface and which in consequence are nearly charge neutral show the magneto-optical properties identical with the properties characteristic of a single graphite sheet, graphene. Inter Landau level transitions in this multilayer graphene have been studied in a wide spectral range from far-infrared to almost visible region. The dispersion relations of electronic states are found to reflect the form of the Dirac cone with almost perfect electron-hole symmetry and only weak deviations from linearity at high energies. Cyclotron resonance transition in multilayer graphene can be observed in magnetic fields down to 40 mT, and its width is practically independent on temperature up to 300 K. Such parameters as carrier mobility and minimal conductivity as well as the possibility to probe the immediate vicinity of the Dirac point were evaluated and discussed in detail. For comparison, the magneto-optical properties of thin layers of bulk graphite were also reported. The Dirac like electronic dispersion relations are also found in these systems, but only in the vicinity of the particular (H) point of the Brillouin zone. In general, the measured spectra are, however, more complex and reflect the three-dimensional character of graphene layers with Bernal stacking. Note from Publisher: This article contains the abstract only.

Background: Relapse of adenocarcinoma of ampulla of Vater (CAV) and its presentation after surgery continuesto be a main issue and its patternsis unknown in our population. Objectives: To describe the relapse patterns after radical surgery and to identify the associated risk factors in a mexican population at a Tertiary Care Center. Methods: Retrospective Study. Patients with CAV who underwent surgery from January 2016 to December of 2020. Relapse: demonstrable disease by means of radiological studies after 3 months of surgery. Main outcomes: patterns of relapse and associated clinical and pathological factors. Results: 72 patients CAV included. Relapse developed in 50% (36), 21 men (58.3%), mean age 60 years (range, 56.9 to 63), 18 in clinical stage III (50%), the procedure mostly performed: Traverso 29 (80.6%), the mean procedure duration: 353 minutes and surgical mortality 9.7%. Pancreatic fistula 33.3% of relapse. CAV relapse: Regional lymph node 19.4%, liver metastasis 52.8%, lung metastasis 27.8%. Mean survival in each relapse pattern: pulmonary metastasis 27.5 months, liver metastasis 25.4 months and lymph nodes metastasis 23.6 months with P=0.002 (95% CI). Mean survival for local relapse 23.6 months and for distant relapse 25.9 months (95%, CI), P=0.29. Identified pancreatic fistula as independent risk factor associated with relapse (HR=2.4, 1.16-4.96, P=0.02). Conclusions: Relapse patterns: liver (52.8%), pulmonar (27.8%) and regional lymph nodes (19.4%) of which regional lymph node relapse seems to have the worst survival prognosis. Pancreatic fistula was related to relapse and survival deterioration. Local or systemic recurrence have similar prognosis. References 1. Ilic M, Ilic I. Epidemiology of pancreatic cancer. World J Gastroenterol. 2016;22(44):9694-9705. doi:10.3748/wjg.v22.i44.9694 2. Sánchez Morales GE, Moguel Valladares RA, Flores Maza J, et al. Pancreatic ductal adenocarcinoma: Eleven years of experience at a tertiary care hospital center. Adenocarcinoma ductal de páncreas. Experiencia de 11 años en un centro de tercer nivel. Rev Gastroenterol Mex (Engl Ed). 2021;86(2):118-124. doi:10.1016/j.rgmx.2020.04.004 3. Zhang H, Lan X, Peng B, Li B. Is total laparoscopic pancreaticoduodenectomy superior to open procedure? A metaanalysis. World J Gastroenterol. 2019;25(37):5711-5731. doi:10.3748/wjg.v25.i37.5711 4. Kalisvaart M, Broadhurst D, Marcon F, et al. Recurrence patterns of pancreatic cancer after pancreatoduodenectomy: systematic review and a single-centre retrospective study. HPB (Oxford). 2020;22(9):1240-1249. doi:10.1016/j.hpb.2020.01.005 5. Nagai S, Fujii T, Kodera Y, et al. Recurrence pattern and prognosis of pancreatic cancer after pancreatic fistula. Ann Surg Oncol. 2011;18(8):2329-2337. doi:10.1245/s10434-011-1604-8 6. Tanaka M, Mihaljevic AL, Probst P, et al. Meta-analysis of recurrence pattern after resection for pancreatic cancer. Br J Surg. 2019;106(12):1590-1601. doi:10.1002/bjs.11295 7. Staerkle RF, Vuille-Dit-Bille RN, Soll C, et al. Extended lymph node resection versus standard resection for pancreatic and periampullary adenocarcinoma. Cochrane Database Syst Rev. 2021;1(1):CD011490. Published 2021 Jan 20. doi:10.1002/14651858.CD011490.pub2 8. Hüttner FJ, Fitzmaurice C, Schwarzer G, et al. Pylorus-preserving pancreaticoduodenectomy (pp Whipple) versus pancreaticoduodenectomy (classic Whipple) for surgical treatment of periampullary and pancreatic carcinoma. Cochrane Database Syst Rev. 2016;2(2):CD006053. Published 2016 Feb 16. doi:10.1002/14651858.CD006053.pub6 9. Ducreux M, Cuhna AS, Caramella C, et al. Cancer of the pancreas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up [published correction appears in Ann Oncol. 2017 Jul 1;28(suppl_4):iv167-iv168]. Ann Oncol. 2015;26 Suppl 5:v56-v68. doi:10.1093/annonc/mdv295 10. Daamen LA, Groot VP, Heerkens HD, Intven MPW, van Santvoort HC, Molenaar IQ. Systematic review on the role of serum tumor markers in the detection of recurrent pancreatic cancer. HPB (Oxford). 2018;20(4):297-304. doi:10.1016/j.hpb.2017.11.009 11. Van den Broeck A, Sergeant G, Ectors N, Van Steenbergen W, Aerts R, Topal B. Patterns of recurrence after curative resection of pancreatic ductal adenocarcinoma. Eur J Surg Oncol. 2009;35(6):600-604. doi:10.1016/j.ejso.2008.12.006 12. Sperti C, Pasquali C, Piccoli A, Pedrazzoli S. Recurrence after resection for ductal adenocarcinoma of the pancreas. World J Surg. 1997;21(2):195-200. doi:10.1007/s002689900215 13. Ma CH, Lee JH, Song KB, Hwang DW, Kim SC. Predictors of early recurrence following a curative resection in patients with a carcinoma of the ampulla of Vater. Ann Surg Treat Res. 2020;99(5):259-267. doi:10.4174/astr.2020.99.5.259 14. Park HM, Park SJ, Han SS, Hong SK, Hong EK, Kim SW. Very early recurrence following pancreaticoduodenectomy in patients with ampullary cancer. Medicine (Baltimore). 2019;98(44):e17711. doi:10.1097/MD.0000000000017711 15. Zhang ZY, Liu DW, Hao DS, Zhou ZQ. Predictors and Recurrence Patterns After Radical Surgery in Ampulla of Vater Cancer: Comparative Analysis Between Early and Late Recurrence. Front Surg. 2022;9:833373. Published 2022 Mar 18. doi:10.3389/fsurg.2022.833373 16. Hsu HP, Shan YS, Hsieh YH, Yang TM, Lin PW. Predictors of recurrence after pancreaticoduodenectomy in ampullary cancer: comparison between non-, early and late recurrence. J Formos Med Assoc. 2007;106(6):432-443. doi:10.1016/S0929-6646(09)60292-8

The early age is a substantial period in human development. The long-term benefit from participating in the early childhood education programs is increasing opportunities for the children to complete their higher education in order to get the better welfare future. In Sumedang regency - the location of this study - the children’s participations in joining the early childhood education programs had not been optimized yet. Approximately 47% of the children aged 4-6 years had not participated in the early childhood education programs yet. Thus, it was significant to seek out the factors influencing the children’s accessibilities to participate in the early childhood education programs in Sumedang regency in order to find out the alternative policy to increase their accessibilities to participate in the early childhoodeducation programs. The research was conducted in 2017 using the quantitative method. The data were obtained from the “2015 Susenas” which involved 300 respondents. The data analysis was performed by using the logistic regression with the 12th version of STATA software. The findings showed that the children’s accessibilities to participate in the early childhood education programs in Sumedang regency was determined by the educational background of the head of family, the marital status of the parents, the head of the family’s income, the number of the family members, and the children’s domicile. Giving knowledge about the importance of early childhood education to the lower educational background parents and enlarging the early childhood schools’ facilities and infrastructures especially in rural areas of Sumedang regency still needed to be improved in order to have better human resources in the future. References Abdulhak, I. (2003). Memposisikan pendidikan anak usia dini dalam sistem pendidikan nasional. Buletin PADU Jurnal Ilmiah Anak Dini Usia. Jakarta: Dir. PAUD, Dirjend. PLSP, Depdiknas. Apriana, R. (2009). Hubungan Pendidikan Anak Usia Dini (PAUD) dengan perkembangan kognitif anak usia prasekolah di Kelurahan Tinmojoyo Kecamatan Banyumanik Semarang. Skripsi. Semarang: Universitas Diponegoro. Aristin, N. F. (2015). Faktor-faktor yang berpengaruh terhadap anak putus sekolah tingkat Sekolah Menengah Pertama (SMP) di Kecamatan Bondowoso. Jurnal Pendidikan Geografi, 20(1). 30-36. doi: http://dx.doi.org/10.17977/pg.v20i1.5009 Bappeda Kab. Sumedang. (2015). Profil daerah Kabupaten Sumedang. Diakses melalui http://www.sumedangkab.go.id/ Berlinski, S. G., Galiani, S., & Gertler, P. (2006). The effect of pre-primary education on primary school performance. Diakses melalui http://eprints.ucl.ac.uk/15418/ Black, M. M., Walker, S. P., Fernald, L. C. H., Andersen, C. T., DiGirolamo, A. M., Lu, C., … Grantham-McGregor, S. (2017). Early childhood development coming of age: science through the life course. The Lancet, 389(10064), 77–90. doi: https://doi.org/10.1016/S0140-6736(16)31389-7 BPS. (2016a). Statistik daerah Kabupaten Sumedang 2016. Kabupaten Sumedang: Badan Pusat Statistik Kabupaten Sumedang. BPS. (2016b). Survey sosial ekonomi nasional. Diakses melalui https://microdata.bps.go.id/mikrodata/index.php/catalog/769 Chen, Y., & Feng, S. (2013). Access to public schools and the education of migrant children in China. ChinaEconomic Review, 26(1), 75–88. doi: https://doi.org/10.1016/j.chieco.2013.04.007 Dewi, N. A. K., Zukhri, A., & Dunia, I. K. (2014). Analisis faktor-faktor penyebab anak putus sekolah usia pendidikan dasar di Kecamatan Gerokgak tahun 2012/2013. Jurnal Jurusan Pendidikan Ekonomi, 4(1), 1-12. http://ejournal.undiksha.ac.id/index.php/JJPE/article/view/1898 Engle, P. L., Fernald, L. C. H., Alderman, H., Behrman, J., O’Gara, C., Yousafzai, A., … Iltus, S. (2011). Strategies for reducing inequalities and improving developmental outcomes for young children in low-income and middle-income countries. The Lancet, 378(9799), 1339–1353. doi: https://doi.org/10.1016/S0140-6736(11)60889-1 Fahmi, M., & Jewelery, P. G. N. (2015). The effect of pre-school education on academic achievement in Indonesia. Working Paper in Economics and Developments Studies, 201505, 1-18. http://ceds.feb.unpad.ac.id/wopeds/201505.pdf Finnie, R., & Mueller, R. E. (2008). The effects of family income, parental education and other background factors on access to postsecondary education in Canada: Evidence from the YITS. SSRN Electronic Journal, 1–52. doi: https://doi.org/10.2139/ssrn.2256114 Heckman, J. (2014). Early childhood development is a smart investment. Diakses melalui https://heckmanequation.org/assets/2014/04/The20Heckman20Curve_v2.jpg Kemdikbud. (2017). Data pokok pendidikan. Diakses melalui http://dapo.dikdasmen.kemdikbud.go.id/ Lake, A. (2011). Early childhood development - Global action is overdue. The Lancet, 378(9799), 1277–1278. doi: https://doi.org/10.1016/S0140-6736(11)61450-5 Majzub, R. M., & Rashid, A. A. (2012). School readiness among preschool children. Procedia - Social and Behavioral Sciences, 46, 3524–3529. doi: https://doi.org/10.1016/j.sbspro.2012.06.098 Mike, I. O., Nakajjo, A., & Isoke, D. (2008). Socioeconomic determinants of primary school dropout : The logistic model analysis. MPRA Paper, 7851, 1-25. https://mpra.ub.unimuenchen.de/7851/ Musyarofah. (2014). Urgensi pendidikan anak usia dini dalam membangun generasi bangsa yang berkarakter. Al-Fitrah, 9(1), 1-20. http://ejournal.iain-jember.ac.id/index.php/alfitrah/article/view/274 Patmonodewo, S. (2003). Pendidikan anak prasekolah (second). Jakarta: PT. Rineka Cipta. Perdana, N. S. (2015). Faktor-faktor yang berpengaruh terhadap aksesibilitas memperoleh pendidikan untuk anak-anak di Indonesia. Jurnal Pendidikan dan Kebudayaan, 21(3), 279–298. doi: http://dx.doi.org/10.24832%2Fjpnk.v21i3.191 Rahman, H. S. (2005). Pendidikan anak usia dini. Yogyakarta: Galah. Rao, N., Sun, J., Chen, E., & Ip, P. (2017). Effectiveness of early childhood interventions in promoting cognitive development in developing countries: A systematic review and meta-analysis. Hong Kong Journal of Paediatrics, 22, 14–25. http://www.hkjpaed.org/pdf/2017;22;14-25.pdf Syahra, R. (2003). Modal sosial : Konsep dan aplikasi perkembangan konsep modal sosial. Jurnal Masyarakat dan Budaya, 5(1), 1–22. doi: http://dx.doi.org/10.14203/jmb.v5i1.256 Todaro, M. P., & Smith, S. C. (2011). Pembangunan ekonomi di dunia ketiga (11th ed.). Jakarta: Erlangga. UNDP. (2015). Work for human development. Diakses melalui http://hdr.undp.org/en/content/human-development-report-2015-work-human-development Warsilah, H. (2017). Pembangunan inklusif dan kebijakan sosial di Kota Solo Jawa Tengah (Edisi Pert). Jakarta: Yayasan Pustaka Obor Indonesia. Yoshikawa, H., Weiland, C., Brooks-gunn, J., Burchinal, M. R., Espinosa, L. M., Gormley, W. T., … Zaslow, M. J. (2013). Investing in our future : The evidence base on preschool education. Society for Research in Child Development, (October), 1–24. https://www.fcd-us.org/assets/2013/10/20Base20on20Preschool20Education20FINAL.pdf Yusuf, A. A. (2017). Menyelesaikan darurat nutrisi anak sebagai prasyarat pertumbuhan inklusif. Diakses melalui http://sdgcenter.unpad.ac.id/menyelesaikan-darurat-nutrisi-anak-sebagaiprasyarat-pertumbuhan-inklusif/ pada tanggal 1 Maret 2018.

BackgroundGliomas represent the most common brain tumors within the central nervous system, with glioblastoma being the most aggressive type.1 Conventional treatment combines several approaches including surgery, chemotherapy, and radiation.2 However, the prognosis for glioblastoma remains unfavorable, with only 5% of patients surviving more than 5 years post-diagnosis.3 Thus, new treatment approaches are urgently needed. Natural killer (NK) cells directly lyse malignantly transformed or virally infected cells and secrete inflammatory cytokines that polarize cytotoxic immunity. Allogeneic NK cell adoptive transfer has shown clinical benefit in patients with advanced cancer.4–7 However, limitations of this approach include relatively low numbers of donor NK cells that can be isolated during an apheresis and variability in the quality of NK cells between donors. To overcome these limitations, we have developed a GMP manufacturing strategy to mass produce NK cells from induced pluripotent stem cells (iPSCs) as an approach to off-the-shelf cancer immunotherapy. We refer to these cells as ‘iNK’ (iPSC-derived NK) cells. Here, we provide preclinical data demonstrating the efficacy of iNK cells for immunotherapy against glioblastoma.Abstract 155 Figure 1Engineered iNK cells exhibit highly effective antitumor function in a xenogeneic model of glioblastoma. (A) Schematic of the experimental design to test iNK cell function against glioblastoma in vivo. (B) Kaplan Meier plots showing survival for groups of mice that received either vehicle alone or iNK cells after tumor engraftment (n=5 mice/group)MethodsWe generated iNK cells using previously published methods.8–10 iNK cells were used as effectors against an array of patient-derived glioblastoma lines in 2-dimensional live imaging IncuCyte assays where iNK cell-mediated killing was observed over the course of 48 hours. To investigate iNK cell infiltration and cytotoxicity in a more physiological context that accounts for the 3-dimensional architecture of the tumor, we also performed live imaging IncuCyte assays using iNK cells as effectors against glioblastoma spheroids. To test the anti-tumor function of iNK cells in vivo, we implanted patient-derived glioblastoma cells into mice via intracranial injection. Seven days later, 5 mice received intratumoral injections of iNK cells, and 5 mice received vehicle alone (as a control; figure 1A). All mice were monitored for weight and survival over 100 days.Results iNK cells exhibited strong and sustained cytotoxicity against 6 primary patient-derived mesenchymal glioblastoma lines in 2-dimensional IncuCyte assays and complete infiltration and destruction of glioblastoma spheroids in 3-dimensional IncuCyte assays. In xenogeneic adoptive transfer experiments, all mice receiving intratumoral injections of iNK cells survived out to day 100, while all mice in the vehicle group became moribund and had to be sacrificed by day 60 (figure 1B).ConclusionsiNK cells are highly cytotoxic against glioblastoma cells, and our preclinical in vivo data provides proof-of-concept for future clinical trials.Ethics ApprovalThis project has been approved by the University of Minnesota IACUC. Approval ID: 1812-36595AReferencesLouis D N, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee W K, Ohgaki H, Wiestler O D, Kleihues P, Ellison D W. The 2016 world health organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 2016;131:803–820.Stupp R, Mason W P, van den Bent M J, Weller M, Fisher B, Taphoorn M J B, Belanger K, Brandes A A, Marosi C, Bogdahn U, Curschmann J, Janzer R C, Ludwin S K, Gorlia T, Allgeier A, Lacombe D, Cairncross J G, Eisenhauer E, Mirimanoff R O, European Organization for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups; National Cancer Institute of Canada Clinical Trials Group. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005;352:987–996.Thakkar JP, Dolecek TA, Horbinski C, Ostrom QT, Lightner DD, Barnholz-Sloan JS, Villano JL. Epidemiologic and molecular prognostic review of glioblastoma. Cancer Epidemiol Biomarkers Prev 2017;23:1985–1996.Miller J S, Soignier Y, Panoskaltsis-Mortari A, McNearney S A, Yun G H, Fautsch S K, McKenna D, Le C, Defor T E, Burns L J, Orchard P J, Blazar B R, Wagner J E, Slungaard A, Weisdorf D J, Okazaki J, McGlave P B. Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer. Blood 2005;105:3051–3057.Bachanova V, Cooley S, Defor T E, Verneris M R, Zhang B, McKenna D H, Curtsinger J, Panoskaltsis-Mortari A, Lewis D, Hippen K, McGlave P, Weisdorf D J, Blazar B R, Miller J S. Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein. Blood 2014;123:3855.Ciurea S O, Schafer J R, Bassett R, Denman C J, Cao K, Willis D, Rondon G, Chen J, Soebbing D, Kaur I, Gulbis A, Ahmed S, Rezvani K, Scpall E J, Lee D A, Champlin R E. Phase 1 clinical trial using mbIL21 ex vivo-expanded donor-derived NK cells after haploidentical transplant. Blood 2017;130:1857–1868.Romee R, Rosario M, Berrien-Elliott M M, Wagner J A, Jewell B A, Schappe T, Leong J W, Abdel-Latif S, Schneider S E, Willey S, Neal C C, Yu L, Oh T, Lee S, Mulder A, Cooper M A, Fehniger T A. Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukiemia. Sci Transl Med 2016:8;375ra123.Valamehr B, Abujarour R, Robinson M, Le T, Robbins D, Shoemaker D, Flynn P. A novel platform to enable the high-throughput derivation and characterization of feeder-free human iPSCs. Sci Rep 2012:2;213.Valamehr B, Robinson M, Abujarour R, Rezner B, Vranceanu F, Le T, Medcalf A, Lee T T, Fitch M, Robbins D, Flynn P. Platform for induction and maintenance of transgene-free hiPSCs resembling ground state pluripotent stem cells. Stem Cell Reports 2014;2:366–381.Zhu H, Blum R H, Bjordahl R, Gaidarova S, Rogers P, Lee T T, Abujarour R, Bonello G B, Wu J, Tsai P-F, Miller J S, Walcheck B, Valamehr B, Kaufman D S. Pluripotent stem cell-derived NK cells with high-affinity noncleavable CD16a mediate improved antitumor immunity. Blood 2020;135:399–410.

Early childhood development (PAUD) is a fundamental investment that is included in the Sustainable Development Goals (SDGs). Previous research has shown that ECD investment in Indonesia, and its financial governance remains a challenging issue. Through a qualitative approach to a case study method design, this study aims to examine the state of PAUD financial management in Panggungharjo Village, Yogyakarta. This study uses in-depth interviews and desk research as data collection techniques. The instrument was developed from the SABER-ECD World Bank Assessment and ECD Financial Profiling Tools. The results showed that PAUD financial management in established villages had innovative financing, budget management and institutional development resulted in a blueprint for managing PAUD financing in other villages in Indonesia. Important policy objectives in all aspects, including the legal framework, cross-sectoral coordination, program coverage, coverage, equity, data availability, quality standards, and compliance with standards, the vision of financing early childhood development will be more achievable for future research. Keywords: Early Childhood, Financial Governance, Village References: Alatas, H., Brinkman, S., Chang, M. C., Hadiyati, T., Hartono, D., Hasan, A., Hyson, M., Jung, H., Kinnell, A., Pradhan, M., & Roesli, R. (2013). Early childhood education and development services in Indonesia. In Education in Indonesia (pp. 82–108). Institute of Southeast Asian Studies. Ambang.Yudanto. (2019). Analisis Kepemimpinan Transformasional Kepala Desa dalam Pengelolaan Badan Usaha Milik Desa: Studi Kasus Bumdes Panggung Lestari, Bantul [Analysis of Village Head Transformational Leadership in Village Owned Enterprise Management: A Case Study of Bumdes Panggung Lestari, Bantul]. The Journal of Business and Management. Antlöv, H., Wetterberg, A., & Dharmawan, L. (2016). Village Governance, Community Life, and the 2014 Village Law in Indonesia. Bulletin of Indonesian Economic Studies, 52(2), 161–183. https://doi.org/10.1080/00074918.2015.1129047 Aqsati, F. A. (2018). Pengelolaan Alokasi Dana Desa untuk Pengembangan Pembedayaan Masyarakat di Desa Panggungharjo [Management of Village Fund Allocation for Community Empowerment Development in Panggungharjo Village]. Resolusi: Jurnal Sosial Politik. Astuti, S. J. W., & Suaedi, F. (2019). Building Independent Villages through Collaborative Governance by Village-Owned Enterprises (Best Practice from Panggungharjo Village, Central Java, Indonesia). Iapa Proceedings Conference, 265. https://doi.org/10.30589/proceedings.2018.200 Basuki, A. F., Setyowati, K., & Wahyunengseh, R. D. (2019). Accountability Model of Financial Management in the Public Sector: A Study on Panggungharjo Village Budget. Bisnis & Birokrasi Journal. https://doi.org/10.20476/jbb.v26i1.10312 Bauhr, M., & Nasiritousi, N. (2013). Resisting Transparency: Corruption, Legitimacy, and the Quality of Global Environmental Policies. Global Environmental Politics, 13(August), 46–64. https://doi.org/10.1162/GLEP Bloom, N., Van Reenen, J., & Williams, H. (2019). A toolkit of policies to promote innovation. Voprosy Ekonomiki, 2019(10), 5–31. https://doi.org/10.32609/0042-8736-2019-10-5-31 Boggild-Jones, I., Gardiner, S., Gustafsson-Wright, E., Castillo, A. M., Castro Espinosa, B., Sánchez Vázquez, G., Rivera Ruíz, M., Hetzel, O., Lugo, H., Khan, A., Mozambique, F., Duarte, S., Fisker, A., Mozambique, A., Briggs, C., Kasajja, M.-S., Anis, K., Campira, P., Figia, N., … Njoroge, S. (2017). Emily Gustafsson-Wright the Standardized Early Childhood Development Costing Tool (SECT) A Global Good to Increase and Improve Investments in Young Children. Brinkman, S. A., Hasan, A., Jung, H., Kinnell, A., & Pradhan, M. (2017). The impact of expanding access to early childhood education services in rural Indonesia. Journal of Labor Economics, 35(S1), S305–S335. https://doi.org/10.1086/691278 Britto, P. R., Engle, P. L., & Super, C. M. (2013). Handbook of Early Childhood Development Research and Its Impact on Global Policy. In Handbook of Early Childhood Development Research and Its Impact on Global Policy. https://doi.org/10.1093/acprof:oso/9780199922994.001.0001 Cardenas, M., & Cadena, A. M. (2020). How to prioritize Early Childhood? A note on the recent expeerience in Columbia. May 2020. Denboba, A., Hasan, A., & Wodon, Q. (2015). Early Childhood Education and Development in Indonesia. In World Bank Publications. Edi, A. C., & Wardhani, I. S. (2019). Transformational and Transactional Leadership, Understanding How Leadership Cultivates Democratic Citizenship in Panggungharjo, Bantul, Yogyakarta. PCD Journal, 6(2), 239. https://doi.org/10.22146/pcd.35229 Hasan, Amer., Hyson, Marilou., & Chu-Chang, M. (2013). Early childhood education and development in poor villages of Indonesia: Strong foundations, later success. World Bank. Istiqomah, L. (2016). Tiga Pilar Kebijakan Pemerintah dalam Pembinaan PAUD. Golden Age [Three Pillars of Government Policy in Early Childhood Education. Golden Age]: Jurnal Ilmiah Tumbuh Kembang Anak Usia Dini. Jeffrey, D. S., & Guido, S. T. (2014). Financing Sustainable Development: Implementing the SDGs through Effective Investment Strategies and Partnerships. Sustainable Development Solutions Network. Juniar, T. (n.d.). Efektivitas Program Kartu Jakarta Pintar (KIP) Dan Manfaatnya Dalam Meningkatkan Kesejahteraan Sosial Di SDN Bintaro 08 Pagi Jakarta Selatan [The Effectiveness of the Jakarta Smart Card (KIP) Program and Its Benefits in Improving Social Welfare at SDN Bintaro 08 Pagi South Jakarta]. Repository.Uinjkt.Ac.Id. Klees, S. J., Ginsburg, M., Anwar, H., Robbins, M. B., Bloom, H., Busacca, C., Corwith, A., Decoster, B., Fiore, A., Gasior, S., Le, H. M., Primo, L. H., & Reedy, T. D. (2020). The World Bank’s SABER: A Critical Analysis. Comparative Education Review. https://doi.org/10.1086/706757 Kurniawati, S., Suryadarma, D., Bima, L., & Yusrina, A. (2018). Education in Indonesia: A white elephant? Journal of Southeast Asian Economies, 35(2), 185–199. https://doi.org/10.1355/ae35-2e Magnuson, K., & Duncan, G. J. (2016). Can early childhood interventions decrease inequality of economic opportunity? Rsf, 2(2), 123–141. https://doi.org/10.7758/rsf.2016.2.2.05 Mizwar Hasyim, N. (2019). Peningkatan Kemandirian Desa Panggungharjo Melalui Komunikasi Pembangunan [Increasing the Independence of Panggungharjo Village through Development Communication]. Jurnal Pemberdayaan Masyarakat: Media Pemikiran Dan Dakwah Pembangunan, 3(2), 352–376. https://doi.org/10.14421/jpm.2019.032-06 Nakajima, N., Hasan, A., Jung, H., Kinnell, A., Maika, A., & Pradhan, M. (2021). Built to Last: Sustainability of Early Childhood Education Services in Rural Indonesia. Journal of Development Studies, 57(10), 1593–1612. https://doi.org/10.1080/00220388.2021.1873283 National Academies of Sciences Engineering and Medicine. (2018). Transforming the Financing of Early Care and Education. In Transforming the Financing of Early Care and Education. The National Academies Press. https://doi.org/10.17226/24984 Penner, E. K., Rochmes, J., Liu, J., Solanki, S. M., & Loeb, S. (2019). Differing views of equity: How prospective educators perceive their role in closing achievement gaps. Rsf, 5(3), 103–127. https://doi.org/10.7758/RSF.2019.5.3.06 Pratama, R. N., & Pambudi, A. (2017). Kinerja Badan Usaha Milik Desa Panggung Lestari dalam Meningkatkan Pendapatan Asli Desa di Desa Panggungharjon Kecamatan Sewon Kabupaten Bantul [Performance of Panggung Lestari Village-Owned Enterprises in Increasing Village Original Income in Panggungharjon Village, Sewon District, Bantul Regency]. Adinegara. Sayre, R. K., Devercelli, A. E., Neuman, M. J., & Wodon, Q. (2015). Investing in Early Childhood Development: Review of the World Bank’s Recent Experience. In Investing in Early Childhood Development: Review of the World Bank’s Recent Experience. https://doi.org/10.1596/978-1-4648-0403-8 Scheerens, J. (2015). School Effectiveness Research. In International Encyclopedia of the Social & Behavioral Sciences: Second Edition (Second Edition, Vol. 21). Elsevier. https://doi.org/10.1016/B978-0-08-097086-8.92080-4 Suryadarma, D., & Jones, G. W. (2013). Education in Indonesia. Education in Indonesia, 39(3), 1–278. The World Bank. (2013). What Matters Most for Early Childhood Development: A Framework Paper. Systems Approach for Better Education Results (SABER) Working Paper Series, 4–59. Vegas, E., & Santibanez, L. (2009). The Promise of Early Childhood Development in Latin America. 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The effect of photon processing (FO) on the formation of a heterojunction in the TiO2/QD’sCdS interface obtained by applying separately synthesized CdS quantum dots to the TiO2 film in the rutile phase has been studied. The changes of luminescence spectra and absorption of the investigated samples after this treatment discovered. It is shown that the separation of charge carriers occurs only after irradiation of samples with a powerful light pulse of a xenon lamp. REFERENCES Kapilashrami M., Zhang Y. , Liu Y.-S., Hagfeldt A., Guo J. Probing the Optical Property and Electronic Structure of TiO2 Nanomaterials for Renewable Ener gy Applications. Chem. Rev., 2014, v. 114, pp. 9662–9707. https://doi.org/10.1021/cr5000893 Dang T. C., Pham D. L., Le H. C., Pham V. H. TiO2/CdS nanocomposite fi lms: fabrication, characterization, electronic and optical properties. Adv. Nat. Sci. Nanosci. Nanotechnol., 2010, v. 1, p. 015002. https://doi.org/10.1088/2043-6254/1/1/015002 Qian X., Qin D., Bai Y., Li T., Tang X., Wang E., Dong S., Photosensitization of TiO2 nanoparticulate thin fi lm electrodes by CdS nanoparticles. J. Solid State Electrochem., 2001, v. 5, pp. 562–567. https://doi.org/10.1007/s100080000179 Baker D. R., Kamat P. V. Photosensitization of TiO2 nanostructures with CdS quantum dots: Particulateversus tubular support architectures. Adv. Funct. Mater., 2009, v. 19, pp. 805–811. https://doi.org/10.1002/adfm.200801173 Cheng S., Fu W., Yang H., Zhang L., Ma J., Zhao H., Sun M., Yang L. Photoelectrochemical performance of multiple semiconductors (CdS/CdSe/ZnS) cosensitized TiO2 photoelectrodes. J. Phys. Chem. C, 2012, v. 116, pp. 2615–2621. https://doi.org/10.1021/jp209258r Khlyap H. Physics and technology of semiconductor thin fi lm-based active elements and devices. Bentham Science Publisher, 2012. https://doi.org/10.2174/97816080502151090101 Milnes A. G., Feucht D. L. Hetero junctions and metal-semiconductor junctions. Academic Press, 418 p. https://doi.org/10.1016/B978-0-12-498050-1.X5001-6 Ievlev V. M., Latyshev A. N., Kovneristyi Y. K., Turaeva T. L., Vavilova V. V., Ovchinnikov O. V., Selivanov V. N., Serbin O. V. Mechanism of the photonic activation of solid-phase processes. High Energy Chem., 2005, v. 39, pp. 397–402. https://doi.org/10.1007/s10733-005-0078-2 Ievlev V. M., Kushchev S. B., Latyshev A. N., Ovchinnikov O. V., Leonova L. Y, Solntsev K. A., Soldatenko S. A., Smirnov M. S., Sinelnikov A. A., Vozgorkov A. M., Ivikova M. A. Relation of absorption band edge of rutile fi lms and their structure. Inorg. Mater. Appl. Res., 2014, v. 5, pp. 14–21. https://doi.org/10.1134/s2075113314010055 Korolev N. V., Smirnov M. S., Ovchinnikov O. V, Shatskikh T.S. Energy structure and absorption spectra of colloidal CdS nanocrystals in gelatin matrix. Phys. E Low-Dimensional Syst. Nanostructures, 2015, v. 68, pp. 159–163. https://doi.org/10.1016/j.physe.2014.10.042. Ghazzal M. N., Wojcieszak R., Raj G., Gaigneaux E.M. Study of mesoporous cds-quantumdot-sensitized TiO2 fi lms by using x-ray photoelectron spectroscopy and afm. Beilstein J. Nanotechnol, 2014, v. 5, pp. 68–76. https://doi.org/10.3762/bjnano.5.6 Ahire R. R., Sagade A. A., Deshpande N. G., Chavhan S. D., Sharma R., Singh F. Engineering of nanocrystalline cadmium sulfi de thin fi lms by using swift heavy ions. J. Phys. D. Appl. Phys., 2007, v. 40, pp. 4850–4854. https://doi.org/10.1088/0022-3727/40/16/014 Ekimov A., Onushchenko A.A. Size quantization of the electron energy spectrum in a microscopic semiconductor crystal. JETP Lett., 1984, v. 40, pp. 1136–1139. Rolo A. G., Stepikhova M. V., Filonovich S. A., Ricolleau C., Vasilevskiy M. I., Gomes M. J. M. Microstructure and photoluminescence of CdS-doped silica fi lms grown by RF magnetron sputtering. Phys. Status Solidi Basic Res., 2002, v. 232, pp. 44–49. https://doi.org/10.1002/1521-3951(200207)232:1<44::AIDPSSB44> 3.0.CO;2-4 Smyntyna V., Skobeeva V., Malushin N. The nature of emission centers in CdS nanocrystals, Radiat. Meas., 2007, v. 42, pp. 693–696. https://doi.org/10.1016/j.radmeas.2007.01.068 Ehemba A. K., Socé M. M., Domingo J. J., Cisse S., Dieng M. Optimization of the properties of the back surface fi eld of a Cu (In, Ga) Se2 thin fi lm solar cell. American Journal of Energy Research, 2017, v. 5(2), pp. 57–62. https://doi.org/10.12691/ajer-5-2-5

This study aims to determine the implementation of curriculum in learning activities of pre-school children and develop motion pattern-based learning media for pre-school children. This research was carried out in thirty kindergartens in East Jakarta. It was conducted in 4 months, from June to October 2018. This research is included in the development and evaluation research (mixed method). The scope of the research is the implementation of curriculum and the development of learning media for pre-school children by using customized tools. Data was collected by using questionnaires and analyzed by using Guttman scale and Likert scale. Percentage of the implementation of learning for pre-schoolers in Kindergarten in East Jakarta is very good. The goal dimension got 98.2%, the content dimension got 99.3%, the method dimension got 99.3% and the evaluation dimension got 98.3%. The product of this study is a learning media that is adjusted to the implementation of motion pattern-based learning activities for pre-school children. Keywords: Early childhood education curriculum, Motion Pattern-Based Learning Media, Pre-school children References Arikunto, S. (2010). Prosedur Penelitian Suatu Pendekatan Praktik. Jakarta: Asdi Mahasatya. Arikunto, S. (2014). Prosedur Penelitian. Jakarta: Rineka Cipta. Ayob, A., Badzis, M., & Nordin, A. L.Abdullah, R. (2016). Kurikulum Permata Negara. Tanjong Malim: NCDRC, UPSI. Azia, R. S. (1976). Curriculum Principles and Foundation. New York: Harper and Row Publisher. Boyle, T., & Phelps, R. (2010). Curriculum To Acknowledge Diversity. The International Journal of Learning, 17(2), 357–370. Brady, L. (1995). Curriculum development (5th ed.). Sydney: Prentice-Hall. Cholimah, N. (2012). Pengembangan Kurikulum PAUD Berdasarkan Permen 58 Tahun 2009. Criticos. (1996). Media. Amazon. George A.Beauchamp. (1981). Curriculum Theory. F.E. Peacock Publisher. Jamaris, M. (2006). Perkembangan dan Pengembangan Anak Usia Dini Taman Kanak-kanak. Jakarta: Gramedia Widiasarana. Johnson, M. (1967). Intentionality in Education. New York: Center for Curriculum Research and Services. Kawaitouw, Y. I., Widiastuti, A. A., & Kurniawan, M. (2018). Unit Studies Curriculum: Strategi Guru Dalam Implementasi Kurikulum di Jungle School Sidomukti. Jurnal Pendidikan Usia Dini, 12(November), 371–380. Kerlinger, F. N. (1990). Asas-asas Penelitian Behavioral (3th ed.). Yogyakarta: Gajah Mada University Press. Langgulung, H. (1989). Manusia dan Pendidikan: Suatu Analisa Psikologik dan Pendidikan. Jakarta: Pustaka al-Husna. MacDonald, J. B. (1965). Educational Models for Instruction. Washington DC: The Association for Supervision and Curriculum Development. Morrison, G. S. (2012). Dasar-dasar Pendidikan Anak Usia Dini. Jakarta: Indeks. Olivia, P. F. (1992). Developing the Curriculum (Third Edit). New York: Harper Collins Publishers Inc. Ornstein, A. C. (2004). Curriculum:Foundation, Principles, and Issues. Boston: Pearson Education, Inc. Ozturk, I. H. (2011). Curriculum Reform and Teacher Autonomy in Turkey: the case of the History Teaching". International Journal of Instruction, 4 (2)(2), 113–127. Prihatini, P. (2014). Kajian Ide Kurikulum 2012 PAUD dan Implikasinya dalam Pengembangan KTSP. Cakrawala: Jurnal Pendidikan Anak USia Dini. Rahelly, Y. (2018). Implementasi Kurikulum 2013 Pendidikan Anak Usia Dini di Sumatera Selatan. Jurnal Pendidikan Usia Dini, 12(November), 381–390. https://doi.org/https://doi.org/10.21009/JPUD.122.19 Rohmansyah, N. A. (2017). Pengaruh Model Pembelajaran Problem Based Learning Terhadap Kemampuan Pemahaman Konsep Pendidikan Jasmani Pada Pembelajaran Tematik Terintegrasi Siswa Kelas IV. JURNAL PENJAKORA, 4(28–35). Saylor, J. G., & Alexander, W. M. (1981). Curriculum Planning for Better Teaching and Learning. Holt-Rinehart and Winston. Sujiono, Y. N. (2009). Konsep Dasar Pendidikan Anak Usia Dini. Jakarta: Indeks. Sukmadinata, N. S. (2000). Pengembangan Kurikulum Teori dan Praktek. Bandung: Remaja Rosdakarya. Sutapa, P. (2014). Pengembangan Model Pembelajaran Pendidikan Jasmani Berbasis Kinestetik Untuk Anak Usia Pra Sekolah. Yogyakarta. Webster. (1993). Webster’s New International Dictionary. GC Company. Widoyoko, E. P. (2012). Evaluasi Program Pembelajaran. Yogyakarta: Pustaka Pelajar. Winarno. (2011). Winarno. Metodologi dalam Penelitian Pendidikan Jasmani. Malang: Media Cakrawala Press. Winarso, W. (2017). Dasar Pengembangan Kurikulum Sekolah, (January 2015).

Abstract Abstract 1761 Chronic lymphocytic leukemia (CLL) is a neoplastic disorder of B-lymphocytes, typically with a high number of peripheral B-lymphocytes and small mature lymphocytes (M Hallek et al, Ann Oncol. 16, Suppl 1:i50-1 (2005). Clinically, some patients have a mild, largely asymptomatic course of the disease and a normal life expectancy, while others suffer from fulminant progression and have a very short survival. An important predictive factor is the presence of typical chromosome aberrations (H Doehner et al, N Engl J Med343, 1910–1916 (2000)). Due to a low proliferative rate of the cells, the gold standard for cytogenetic diagnostics in CLL is fluorescence in situ hybridization (FISH). Therefore, not much is known about the incidence of complex karyotypes, although they are strong predictors of a very poor prognosis in CLL (C Mayr et al, Blood107, 742–751 (2007)). By stimulating the cells with different interleukins and CpG-oligodeoxynucleotides, we were able to detect complex karyotypes in about 10% of investigated cases of CLL by classical banding analysis. In this study, we characterized 24 patients with CLL and complex karyotype by performing multicolor fluorescence in situ hybridization (mFISH). Hereby, we could identify cryptic aberrations and describe the karyotype in greater detail. In addition to typical aberrations involving 6q, 11q, 13q and 17p and trisomy 12, (iso)dicentric chromosomes and whole-arm translocations of chromosomes Y, 1, 3, 4, 5, 13, 15, 17, 18, 21 and 22 were detected. These chromosome aberrations were mostly generated by breaks in heterochromatic and telomeric regions indicating an increased breakage of these regions. This may indicate that epigenetic alterations and critically short telomeres predispose for the generation of chromosome aberrations in CLL. Telomere shortening and chromosomal instability are believed to play an important role in the development of neoplasia. Recently, it was shown that short telomeres in CLL are associated with a poor survival and increased genetic complexity (G Roos et al, Blood111, 2246–2252 (2008)). So far, published data are only available on the average telomere length in CLL, but not on the telomere length of individual chromosomes. We used a new technique, telomere/centromere-fluorescence in situ hybridization (T/C-FISH), which combines fluorescence R-banding and FISH using a probe against the telomere repeats to measure the telomere length of each chromosome arm. In line with previous results, patients with CLL showed significantly shorter telomeres than those of healthy controls. Comparing the telomere lengths of distinct chromosome arms with specific aberrations, there was no significant association. In addition, we could compare the telomere lengths of cells with aberrations and cells without aberrations within one patient. Aberrant metaphases of the same patient showed significantly shorter telomeres than metaphases with a normal karyotype (p<0.05). Thus, telomere shortening is not a basic mechanism affecting all hematopoietic cells in CLL patients, e.g. due to aging, but affects only the malignant cells, indicating that telomere attrition is involved in the pathogenesis of CLL with complex karyotypes. Disclosures: No relevant conflicts of interest to declare.

Demand for mineral resources is increasing, necessitating exploitation of lower grade and more heterogeneous orebodies. The high variability inherent in such orebodies leads to an increase in the cost, complexity and environmental footprint associated with mining and mineral processing. Enhanced knowledge of orebody characteristics is thus vital for mining companies to optimize profitability. We present a pilot study to investigate prediction of geometallurgical variables from drill sensor data. A comparison is made of the performance of multilayer perceptron (MLP) and multiple linear regression models (MLR) for predicting a geometallurgical variable. This comparison is based on simulated data that are physically realistic, having been derived from models fitted to the one available drill core. The comparison is made in terms of the mean and standard deviation (over repeated samples from the population) of the mean absolute error, root mean square error, and coefficient of determination. The best performing model depends on the form of the response variable and the sample size. The standard deviation of performance measures tends to be higher for the MLP, and MLR appears to offer a more consistent performance for the test cases considered. References R. M. Balabin and S. V. Smirnov. Interpolation and extrapolation problems of multivariate regression in analytical chemistry: Benchmarking the robustness on near-infrared (NIR) spectroscopy data”. Analyst 137.7 (2012), pp. 1604–1610. doi: 10.1039/c2an15972d C. M. Bishop. Pattern recognition and machine learning. Springer, 2006. url: https://link.springer.com/book/9780387310732 J. B. Boisvert, M. E. Rossi, K. Ehrig, and C. V. Deutsch. Geometallurgical modeling at Olympic dam mine, South Australia”. Math. Geosci. 45 (2013), pp. 901–925. doi: 10.1007/s11004-013-9462-5 T. Bollerslev. Generalized autoregressive conditional heteroskedasticity”. J. Economet. 31.3 (1986), pp. 307–327. doi: 10.1016/0304-4076(86)90063-1 C. Both and R. Dimitrakopoulos. Applied machine learning for geometallurgical throughput prediction—A case study using production data at the Tropicana Gold Mining Complex”. Minerals 11.11 (2021), p. 1257. doi: 10.3390/min11111257 J. Chen and G. Li. Tsallis wavelet entropy and its application in power signal analysis”. Entropy 16.6 (2014), pp. 3009–3025. doi: 10.3390/e16063009 S. Coward, J. Vann, S. Dunham, and M. Stewart. The primary-response framework for geometallurgical variables”. Seventh international mining geology conference. 2009, pp. 109–113. https://www.ausimm.com/publications/conference->url: https://www.ausimm.com/publications/conference- proceedings/seventh-international-mining-geology- conference-2009/the-primary-response-framework-for- geometallurgical-variables/ A. C. Davis and N. B. Christensen. Derivative analysis for layer selection of geophysical borehole logs”. Comput. Geosci. 60 (2013), pp. 34–40. doi: 10.1016/j.cageo.2013.06.015 C. Dritsaki. An empirical evaluation in GARCH volatility modeling: Evidence from the Stockholm stock exchange”. J. Math. Fin. 7.2 (2017), pp. 366–390. doi: 10.4236/jmf.2017.72020 R. F. Engle and T. Bollerslev. Modelling the persistence of conditional variances”. Econ. Rev. 5.1 (1986), pp. 1–50. doi: 10.1080/07474938608800095 A. S. Hadi and R. F. Ling. Some cautionary notes on the use of principal components regression”. Am. Statistician 52.4 (1998), pp. 15–19. doi: 10.2307/2685559 J. Hunt, T. Kojovic, and R. Berry. Estimating comminution indices from ore mineralogy, chemistry and drill core logging”. The Second AusIMM International Geometallurgy Conference (GeoMet) 2013. 2013, pp. 173–176. http://ecite.utas.edu.au/89773>url: http://ecite.utas.edu.au/89773 on p. C210). R. Hyndman, Y. Kang, P. Montero-Manso, T. Talagala, E. Wang, Y. Yang, M. O’Hara-Wild, S. Ben Taieb, H. Cao, D. K. Lake, N. Laptev, and J. R. Moorman. tsfeatures: Time series feature extraction. R package version 1.0.2. 2020. https://CRAN.R-project.org/package=tsfeatures>url: https://CRAN.R-project.org/package=tsfeatures on p. C222). C. L. Johnson, D. A. Browning, and N. E. Pendock. Hyperspectral imaging applications to geometallurgy: Utilizing blast hole mineralogy to predict Au-Cu recovery and throughput at the Phoenix mine, Nevada”. Econ. Geol. 114.8 (2019), pp. 1481–1494. doi: 10.5382/econgeo.4684 E. B. Martin and A. J. Morris. An overview of multivariate statistical process control in continuous and batch process performance monitoring”. Trans. Inst. Meas. Control 18.1 (1996), pp. 51–60. doi: 10.1177/014233129601800107 E. Sepulveda, P. A. Dowd, C. Xu, and E. Addo. Multivariate modelling of geometallurgical variables by projection pursuit”. Math. Geosci. 49.1 (2017), pp. 121–143. doi: 10.1007/s11004-016-9660-z S. J. Webb, G. R. J. Cooper, and L. D. Ashwal. Wavelet and statistical investigation of density and susceptibility data from the Bellevue drill core and Moordkopje borehole, Bushveld Complex, South Africa”. SEG Technical Program Expanded Abstracts 2008. Society of Exploration Geophysicists, 2008, pp. 1167–1171. doi: 10.1190/1.3059129 R. Zuo. Identifying geochemical anomalies associated with Cu and Pb–Zn skarn mineralization using principal component analysis and spectrum–area fractal modeling in the Gangdese Belt, Tibet (China)”. J. Geochem. Explor. 111.1-2 (2011), pp. 13–22. doi: 10.1016/J.GEXPLO.2011.06.012

In the past decade the eighteenth-century London music publisher John Walsh has been subject to a new evaluation with regard to his pirated editions and deliberate misattributions, especially of the music of George Frideric Handel. That Walsh's attributions were anything but trustworthy had already been recognized in the eighteenth century: a surviving copy (London, British Library, BM g.74.d) of his first edition of the Sonates pour un traversiere un violon ou hautbois con basso continuo composées par G. F. Handel (c.1730), which, as Donald Burrows and Terence Best have shown, was provided with a title-page designed to simulate that of Jeanne Roger, bears the manuscript inscription ‘NB This is not Mr. Handel's’ in an eighteenth-century hand at the beginning of the tenth and twelfth sonatas, precisely those that Walsh removed in his second edition of this collection (c. 1731–2), advertised on the title-page as being ‘more Corect [sic] than the former Edition’. In the second edition Walsh substituted two equally questionable works in their place, each of which bears the handwritten inscription ‘Not Mr. Handel's Solo’ in a copy in the British Library (BM g.74.h). Two of the sonatas attributed to Handel in Walsh's Six Solos, Four for a German Flute and a Bass and Two for a Violin with a Thorough Bass … Composed by Mr Handel, Sigr Geminiani, Sigr Somis, Sigr Brivio (1730; in A minor and B minor) are also possibly spurious, while three of the four movements of the remaining sonata attributed to Handel in this collection (in E minor) are movements arranged from his other instrumental works. And in 1734 Johann Joachim Quantz, to whom Walsh devoted four volumes of solo sonatas (1730–44), complained of the publication of spurious and corrupted works:There has been printed in London and in Amsterdam under the name of the [present] author, but without his knowledge, 12 sonatas for the transverse flute and bass divided into two books. I am obliged to advertise to the public that only the first, second, fourth, fifth and sixth [sonatas] from the first book, and the first three from the second book, are his [Quantz's] compositions; and that he furthermore wrote them years ago, and besides they have, due to the negligence of the copyist or the printer, gross errors including the omission of entire bars, and that he does not sanction the printing of a collection that has no relationship with the present publication that he sets before the public.

Study on ammonia nitrogen and phosphorus removal using sequencing batch reactor Samaneh Alijantabar Aghouzi * Department of Chemical and Environmental Engineering, Faculty of Engineering Universiti Putra Malaysia, Serdang Malaysia Thomas S. Y. Choong Sustainable Process Engineering Research Center (SPERC) Universiti Putra Malaysia, Serdang Malaysia Aida Isma M. I. Centre for Water Research, Faculty of Engineering and the Built Environment SEGi University, Kota Damansara Malaysia *Corrosponding author’s Email: sam.alijani@gmail.com Peer-review under responsibility of 3rd Asia International Multidisciplanry Conference 2019 editorial board (http://www.utm.my/asia/our-team/) © 2019 Published by Readers Insight Publisher, lat 306 Savoy Residencia, Block 3 F11/1,44000 Islamabad. Pakistan, info@readersinsight.net This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). _________________________________________________________ Research Highlights The highest phosphorus and ammonia nitrogen removal efficiencies were 99.5% and 51%, respectively, in 6 hours. Particle size of sludge reduced from 26 μm to 39.81 μm in 60 days. Fourier transform infrared spectroscopy (FTIR) showed that N-O, N–H, S=O and C=N compunds detected. ___________________________________________________________________________ Research Objectives Ammonia nitrogen and phosphorus removal have becoming more rigorous in permits making it one of the most important and most difficult processes to maintain in wastewater treatment plants. Sequencing batch reactor is a controlled activated sludge process that is able to tackle ammonia nitrogen and phosphorus issues and has some benefits such as having a small-scale system and low construction cost (1). The main goal of this research is to investigate the ability of SBR in treating sewage containing phosphorus and ammonia nitrogen in 6 hours to achieve the allowable effluent discharge standard set by the Department of Environment Malaysia. Materials and Methods In this experiment, a sequencing batch reactor with a total volume of 7 L. The mechanical stirrer was used to avoid sludge settling with a speed of 100 rpm. A fine bubble diffuser was used to supply air. The operation time was controlled based on 1 h and 30 mins anaerobic, 2 h and 10 mins anoxic, 1 h and 50 mins aerobic, making the hydraulic retention time (HRT) of 6 hours. 10 L seed sludge and 30 L raw sewage samples were collected weekly from the sewage treatment plant that was located in Selangor and were kept under 4oC in cold room in order to obtain fresh samples. The sludge volume was 30% of raw sewage volume in the reactor and the reactor refilled with 3.5 liters of raw sewage at the start point of the experiment. The experiment was carried out in room temperature of 27±3 oC with the pH value ranging from 6 to 8 and dissolve oxygen value ranging from 0 to 6 mg/L. Phosphorus and ammonia nitrogen were measured according to the APHA method (2). DO and PH were measured by using DO meter (JPB-70A) and PH meter (CT-6821, Shenzhen Kedida Electronic CO). Results The highest ammonia nitrogen removal efficiencies observed to be 31.9 %, 10.3 % and 38.8 % at the respective phases of anaerobic, anoxic and aerobic, respectively. Results showed that the phosphorus removal efficiencies for anaerobic, anoxic and aerobic phases were 70.43 %, 19.16%, and 98.58%, respectively in 6 hours. The highest phosphorus removal efficiency recorded was 98.58% that took place in the aerobic phase because of the absence of sufficient nitrate which can inhibit phosphorus uptake during the aerobic phase. The most sensitive process is nitrification that helps to biological oxidation of ammonia to nitrate, which is performed by two types of microorganisms, i.e. ammonia-oxidizing bacteria (AOB) and nitrite-oxidizing bacteria (NOB) (3). Karl et al. claimed that toxic substances inhibit the metabolism of bacteria (4). Mino et al. (5) also stated that nitrification process will not be accomplished in anaerobic phase without the presence of nitrate. This will affect the phosphorus uptake in the aeration phase. Findings FTIR spectrum shows that N-O, N–H, S=O and C=N compounds were identified in the sludge. The presence of these compounds might affect the nitrification and denitrification processes and indirectly affecting the degradation the ammonia nitrogen and phosphorus. Sewage sample might also contain heavy metals as the sewage treatment plant was located in the industrial area. Acknowledgment The authors gratefully thank the financial and research support of Universiti Putra Malaysia. References Sathian, S, M Rajasimman, C S Rathnasabapathy, and C Karthikeyan. 2014. “Journal of Water Process Engineering Performance Evaluation of SBR for the Treatment of Dyeing Wastewater by Simultaneous Biological and Adsorption Processes.” Journal of Water Process Engineering 4: 82–90. APHA. Standard Methods For the examination of water and Wastewater 23rd ed. ed. Washington, D.C.2017. Chang HN, Moon RK, Park BG, Lim S, Choi DW. Simulation of sequential batch reactor ( SBR ) operation for simultaneous removal of nitrogen and phosphorus. 2000;23. Karl DM, States U. Nitrogen Cycle ☆. 3rd ed. Encyclopedia of Ocean Sciences, 3rd Edition. Elsevier Inc.; 2018. 1-10 p. Mino T, Loosdrecht MCM van, Heijnen JJ. Microbiology and biochemistry of the EBPR process. Water Res. 1998;32(11):3193–207.

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Abstract Background: Neoadjuvant anti-PD-1-based therapies have shown promise in several cancers, including Merkel cell carcinoma (MCC), a rare and aggressive skin cancer. We have shown that on-treatment specimens from patients responding to anti-PD-1 are characterized histologically by exuberant proliferative fibrosis, neovascularization, and robust inflammation including diverse immune cell types. Understanding how the stroma participates in the process of tumor regression may open therapeutic opportunities by redirecting stromal remodeling in treatment-refractory tumors. Methods: To evaluate stromal changes in neoadjuvant treated MCC, 13 on-treatment FFPE tumor specimens from patients with resectable MCC who received anti-PD-1 for ~4 weeks before surgery (NCT02488759) were subjected to laser capture microdissection to collect stromal tissue and isolate RNA. We conducted multiplex qRT-PCR targeting 125 unique mRNAs representing TME-relevant immune cell subsets, immune checkpoint pathways, and immune-modulating transcription factors and cytokines, followed by whole transcriptome RNA sequencing. Differential gene expression was considered significant if the magnitude of the signed fold-change was ≥2 and the p-value was ≤0.1 (Benjamini-Hochberg adjusted for RNAseq). Gene set enrichment analysis (GSEA) was performed with R Topper. Pathologic response was scored on H&E staining as pathologic complete response (pCR, n=6), major pathologic response (MPR, ≤10% residual viable tumor [RVT]; n=4), or non-MPR/pCR (&gt;10% RVT; n=3). Results: Stratifying by response status (6 pCR vs 3 non-MPR/pCR) demonstrated that pCR stroma in MCC is distinguished by upregulation of molecules associated with neovascularization (VEGFA, EGR2) and M1 and M2 macrophages (IL1A, ARG1) via qRT-PCR, and mesenchymal cells (fibroblasts, myocytes, adipocytes) and extracellular matrix formation via RNAseq. GSEA demonstrated a strong association of pCR with both myocyte and fibroblast differentiation and functional pathways, suggesting a role for myofibroblasts in tissue remodeling during anti-PD-1-mediated tumor regression. In contrast, the stroma of non-MPR/pCR tumors showed evidence for ongoing IFNg-mediated inflammation, as evidenced by upregulation of IFNg, IL-27, STAT1, CXCL10 and LAG-3 via qRT-PCR; these findings were supported by RNAseq, which also showed upregulation of genes associated with inflammation (e.g., PLXNC1, TRPV2, LYZ, LAIR1, HLA-A, B2M, CD4). Similar results were obtained when MPRs were grouped with pCRs (n=10) vs non-MPR/pCR (n=3). Conclusion: These findings demonstrate that improved response to anti-PD-1 therapy is associated with a shift in the tumor stroma from an inflammatory to a proliferative myofibroblastic phenotype, recapitulating the stages of normal wound healing. This suggests a potential functional role for myofibroblasts in that critical transition. Citation Format: Joel C. Sunshine, Tracee L. McMiller, Alyza Skaist, Yan Zhang, Alan Berger, Kornel Schuebel, Jennifer Meyers, Julie S. Deutsch, Aleksandra Ogurtsova, Elizabeth L. Engle, Leslie Cope, Janis M. Taube, Suzanne L. Topalian. Characterizing tumor stromal evolution after neoadjuvant anti-PD-1 therapy in Merkel cell carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 2260.

Potential use of lithium metal anode is a primary factor behind the high-energy density promise of solid-state batteries. However, large anodic loads lead to void formation and contact loss at the lithium/solid electrolyte interface which, in turn, lead to much higher effective local current densities during the subsequent lithium plating, causing dendrite formation and cell shorting.1, 2 This is due to the slow self-diffusion of Li atoms/vacancies, which is an inherent limitation of lithium metal.3 Modifying the bulk physiochemical properties of lithium metal via doping/alloying (<10 at% dopant) is an attractive approach, as such a small concentration of dopants can alter lithium metal’s bulk properties, without lowering its energy density. As an example, pore formation was effectively eliminated by alloying Li with 10 at% Mg, although chemical diffusion of Li within the alloy still restricted its rate performance.4 In this work, we report the effects of Ag as a dopant on the morphological stability and rate capability of Li-Ag alloy anodes during electrochemical cycling, as its concentration is varied in Li from 0-10 at.%. The alloy samples are prepared as 10 μm thick films, a practical form factor for solid-state batteries, via a combination of sputtering and thermal evaporation. Comparison of performance as a function of Ag content will be presented for both polymeric and inorganic solid-state electrolytes. Structural characterization of the alloy anodes via complementary techniques will also be presented. This research was sponsored by the Laboratory Directed Research and Development Program of Oak Ridge National Laboratory (ORNL). This abstract has been authored by UT-Battelle, LLC, under contract DE-AC05-00OR22725 with the US Department of Energy (DOE). The US government retains and the publisher, by accepting the article for publication, acknowledges that the US government retains a nonexclusive, paid-up, irrevocable, worldwide license to publish or reproduce the published form of this manuscript, or allow others to do so, for US government purposes. DOE will provide public access to these results of federally sponsored research in accordance with the DOE Public Access Plan (http://energy.gov/downloads/doe-public-access-plan). References Kasemchainan, J.; Zekoll, S.; Spencer Jolly, D.; Ning, Z.; Hartley, G. O.; Marrow, J.; Bruce, P. G., Critical stripping current leads to dendrite formation on plating in lithium anode solid electrolyte cells. Nature Materials 2019, 18 (10), 1105-1111. Krauskopf, T.; Hartmann, H.; Zeier, W. G.; Janek, J., Toward a Fundamental Understanding of the Lithium Metal Anode in Solid-State Batteries—An Electrochemo-Mechanical Study on the Garnet-Type Solid Electrolyte Li6.25Al0.25La3Zr2O12. ACS Applied Materials & Interfaces 2019, 11 (15), 14463-14477. Jow, T. R.; Liang, C. C., Interface Between Solid Electrode and Solid Electrolyte—A Study of the Li / LiI ( Al2 O 3 ) Solid‐Electrolyte System. Journal of The Electrochemical Society 1983, 130 (4), 737-740. Krauskopf, T.; Mogwitz, B.; Rosenbach, C.; Zeier, W. G.; Janek, J., Diffusion Limitation of Lithium Metal and Li–Mg Alloy Anodes on LLZO Type Solid Electrolytes as a Function of Temperature and Pressure. Advanced Energy Materials 2019, 9 (44), 1902568.

BackgroundPancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with short overall survival; the standard of care (SoC) is chemotherapy. Immunotherapies in development aim to remodel the stroma by depleting immunosuppressive cell types or using T-cell redirection to kill tumor cells. To date, none of these methods have improved overall survival beyond SoC. Next generation immunotherapies that employ histopathology and molecular subtyping1 for target and patient selection may succeed. Here we leverage a spatial transcriptomics platform (Nanostring Digital Spatial Profiling, DSP) to reveal molecular signaling in tumoral and stromal cells in 57 PDAC patients using tumor microarrays (TMAs). This approach is rapid and clinically relevant as molecular and histology data can be easily bridged.MethodsTMAs generated from surgical resection tissue were commercially sourced. DSP was performed using the CTA RNA panel (1,800 target genes) using PanCK fluorescence for tumor/stroma segmentation. In parallel, slides were chromogenically stained for T-cells (CD3) and macrophages (CD68/CD163). Differential gene expression, gene signature and gene co-expression network analysis was performed using linear models in R.2 3ResultsDifferential gene expression analysis and correlation to IHC confirmed the DSP platform successfully profiled tumor and stromal compartments (figure 1). Immune cell signatures4 and pathway analysis revealed a heterogenous stromal environment. Using a fibroblast gene signature derived from single-cell RNAseq5 we found fibroblast density was positively correlated to PDGFR signaling and MHC-II expression but negatively correlated to B, CD4+ T and neutrophil cell levels (figure 2a). This finding supports the idea that atypical antigen presentation in cancer associated fibroblasts (CAFs) may be exploitable for immunotherapies.6 We constructed a co-expression network from in-situ stromal gene expression and used it to identify receptors coordinately expressed with the immunosuppressive macrophage marker CSF1R as a bispecific antibody partner (figure 2b).7 Classical macrophage markers were identified but also receptors with lesser-known functions in macrophages (TIM3/HAVCR2, FPR3, MS4A6A, LILRB4). Surveying target pairs in this method allows rapid, patient-specific confirmation in serial TMA sections with singleplex IHC or RNAscope.Abstact 928 Figure 1Segmentation strategy and validation of DSP (A) PanCK, CD68 and CD3 staining from two representative tumor cores; (B, C) correlation of gene transcripts in stroma to cell counts from chromogenic staining; (D) heatmap of selected genes differentially expressed in tumor and stroma (n=57 patients).Abstract 928 Figure 2Exploration of the stromal compartment in PDAC TMAs. (A) Heatmap of selected cell type and gene signatures from gene expression in the stroma, color represents single sample enrichment score using GSVA method; (B) a gene co-expression subnetwork in the stroma centered on CSF1R, edge thickness represents strength of correlation, green nodes have evidence for cell surface expression based on proteomic profiling.7ConclusionsIn this study we were able to recapitulate known PDAC biology using very small samples of primary tumors. The combination of TMAs and DSP enables a rapid validation of targets and hypothesis generation for bispecific parings. Further analysis of untreated (n=14) and post-adjuvant chemotherapy (n=26) patients using RNA DSP, IHC and bulk RNAseq is under way. Results from this cohort will enable an integrated histopathology and molecular approach to developing next-generation immunotherapies.ReferencesCollisson EA, Bailey P, Chang DK, Biankin AV. Molecular subtypes of pancreatic cancer. Nat Rev Gastroenterol Hepatol 2019 April;16(4):207–220.Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, Smyth GK (2015). “limma powers differential expression analyses for RNA-sequencing and microarray studies.” Nucleic Acids Research 43(7):e47.Hänzelmann S, Castelo R, Guinney J (2013). “GSVA: gene set variation analysis for microarray and RNA-Seq data.” BMC Bioinformatics 14,7.Charoentong P, Finotello F, Angelova M, Mayer C, Efremova M, Rieder D, Hackl H, Trajanoski Z. Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade. Cell Rep 2017 January 3;18(1):248–262.Tirosh I, Izar B, Prakadan SM, Wadsworth MH 2nd, Treacy D, Trombetta JJ, Rotem A, Rodman C, Lian C, Murphy G, Fallahi-Sichani M, Dutton-Regester K, Lin JR, Cohen O, Shah P, Lu D, Genshaft AS, Hughes TK, Ziegler CG, Kazer SW, Gaillard A, Kolb KE, Villani AC, Johannessen CM, Andreev AY, Van Allen EM, Bertagnolli M, Sorger PK, Sullivan RJ, Flaherty KT, Frederick DT, Jané-Valbuena J, Yoon CH, Rozenblatt-Rosen O, Shalek AK, Regev A, Garraway LA. Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq. Science 2016 April 8;352(6282):189–96.Elyada E, Bolisetty M, Laise P, Flynn WF, Courtois ET, Burkhart RA, Teinor JA, Belleau P, Biffi G, Lucito MS, Sivajothi S, Armstrong TD, Engle DD, Yu KH, Hao Y, Wolfgang CL, Park Y, Preall J, Jaffee EM, Califano A, Robson P, Tuveson DA. Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts. Cancer Discov 2019 August;9(8):1102–1123. Bausch-Fluck D, Hofmann A, Bock T, Frei AP, Cerciello F, Jacobs A, Moest H, Omasits U, Gundry RL, Yoon C, Schiess R, Schmidt A, Mirkowska P, Härtlová A, Van Eyk JE, Bourquin JP, Aebersold R, Boheler KR, Zandstra P, Wollscheid B. A mass spectrometric-derived cell surface protein atlas. PLoS One 2015 April 20;10(3):e0121314.Ethics ApprovalSpecimens were harvested from unused tissue after a surgical tumor resection procedure. A discrete legal consent form from both hospital and individuals was obtained by the commercial tissue vendor BioMax US for all samples analyzed in this abstract. All human tissues are collected under HIPPA approved protocols.ConsentWritten informed consent was obtained from the patient for publication of this abstract and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.

O artigo tem como proposta analisar os saberes teóricos e práticos que envolvem o jornalismo investigativo e sua prática no Brasil. A discussão analisa as quatro reportagens premiadas da Agência Pública em 2014, exclusivamente de autoria feminina. O referencial teórico utilizado pauta-se em deontologias do jornalismo, jornalismo investigativo e métodos de apuração. Escolheu-se a Agência Pública pelo pioneirismo de sua proposta no Brasil.Palavras-Chave: Jornalismo Investigativo; Métodos de Apuração em Jornalismo investigativo; Agência Pública. ABSTRACTThe article aims to analyze the theoretical and practical knowledge involving investigative journalism, its theoretical and methodological knowledge and practice in Brazil. The discussion analyzes the four reports awarded the Public Agency in 2014, exclusively female authors. The theoretical framework is based on deontology of journalism, investigative reporting and verification methods. We picked up the Public Agency for pioneering its proposal in Brazil.Keywords: Investigative Journalism; Verification Methods in Investigative Journalis; Public Agency. RESUMENEl artículo tiene como objetivo analizar los conocimientos teóricos y prácticos que implica el periodismo de investigación y su práctica en Brasil. La discusión analiza los cuatro informes otorgados a la Agencia Pública de 2014, exclusivamente autoras mujeres. El marco teórico está en la deontología del periodismo, el periodismo de investigación y métodos de verificación. Recogimos la Agencia Pública por ser pionero en su propuesta en Brasil.Palabras clave: Periodismo de Investigación; Metodos de Investigación; Agencia Publica. Referências BURG, H. de. Investigative Journalism. New York, Routledge, 2008.COSTA, N. Lugar de mulher é na redação. O Jornalismo Performático e o destaque alcançado por repórteres mulheres. In. Seminário Internacional Fazendo Gênero 10 (Anais Eletrônicos), Florianópolis, 2013CHAMBERS, D., STEINER, L., FLEMING, C. Women and Journalism. New York: Rutledge, 2004.IMPRENSA Observatório da. Pública - Agência de Reportagem e Jornalismo Investigativo, 2012. Disponível emKEATING, P. The Haunted study. London, Fontana, 1991KOVACH, B. e ROSENSTIEL, T. Os elementos do Jornalismo. O que os jornalistas devem saber e o público exigir. São Paulo, Geração Editorial, 2004.LEITE, A. T. B.. Profissionais da mídia em São Paulo: Um estudo sobre profissionalismo, diferença e gênero no jornalismo. São Carlos: UFSCar, 2015. 232p. Tese (Doutorado) - Programa de Pós Graduação em Ciências Sociais, Faculdade de Ciências Sociais da Universidade Federal de São Carlos, São Carlos, 2015.LOPES, D. F.; PROENÇA, J.L. Jornalismo Investigativo. São Paulo, Publisher Brasil, 2003NASCIMENTO, S. Os novos escribas. O fenômeno do jornalismo sobre investigações no Brasil. Porto Alegre, Arquipélago Editorial, 2010.SEQUEIRA, C. M. de. Jornalismo Investigativo: O fato por trás da notícia. São Paulo: Ed. Summus. 2005.SILVEIRINHA, M. J. Revisitar o passado na América: a "questão de ser mulher" no jornalismo. ln: Estudos do Século XX, nº 7. p. 115-132: Imprensa da Universidade Coimbra, 2007.WALSH, R. Operação Massacre. São Paulo, Companhia das Letras, 2010. Disponível em:Url: http://opendepot.org/2715/PID: http://www.ssoar.info/ssoar/handle/document/45814 Abrir em (para melhor visualização em dispositivos móveis - Formato Flipbooks):Issuu / Calameo

Early childhood emotional dysregulation is critical in recognizing and preventing psychological well-being disorders, laying the groundwork for developing healthy emotional behaviors early on. This study aims to determine the direct influence of smartphone addiction, executive function, and the mother-child relationship on emotional dysregulation in early childhood in West Sumatra. This research method is a quantitative survey. The data collection technique in this research uses a questionnaire design on 309 parents who were selected using a simple random sampling method. This data processing tool uses the SmartPLS software. The results of the study indicate that smartphone addiction has a significant impact on emotional dysregulation in early childhood, executive function has a positive and significant effect on emotional dysregulation in early childhood, and the mother-child relationship has a positive and significant influence on emotional dysregulation in early childhood. The findings of this research can offer valuable insights into improving the understanding of the factors that influence emotional dysregulation in early childhood and intervention strategies to address the issues that arise as a result. Keywords: smartphone addiction, executive function, mother-child relationship, emotional dysregulation, early childhood References: Aisyah, Salehudin, M., Yatun, S., Yani, Komariah, D. L., Aminda, N. E. R., Hidayati, P., & Latifah, N. (2021). Persepsi Orang Tua Dalam Pendidikan karakter Anak Usia Dini Pada Pembelajaran Online di Masa Pandemi Covid-19. PEDAGOGI: Jurnal Anak Usia Dini Dan Pendidikan Anak Usia Dini, 7(1), 60–75. https://doi.org/http://dx.doi.org/10.30651/pedagogi.v7i1.6593 Allison, S. Z. (2023). Islamic Educational Provisions in South Korea and Indonesia : A Comparison. Journal of Islamic Education Students, 3, 50–61. https://doi.org/10.31958/jies.v3i1.8772 Anggraini, E. (2019). Mengatasi Kecanduan Gadget Pada Anak. Serayu Publishing. 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Journal of Islamic Education Students (JIES), 2(1), 12. https://doi.org/10.31958/jies.v2i1.4367 Ayomi, A. T. R., Widyorini, E., & Roswita, M. Y. (2021). Hubungan Inteligensi dengan Fungsi Eksekutif pada Anak Gifted Relationship between Intelligence and Executive Function to Gifted Children. Jurnal Ilmiah Psikologi Candrajiwa, 6(2), 136. Bachtiar, M. A., & Faletehan, A. F. (2021). Self-Healing sebagai Metode Pengendalian Emosi. Journal An-Nafs: Kajian Penelitian Psikologi, 6(1), 41–54. https://doi.org/10.33367/psi.v6i1.1327 Baptista, J., Osório, A., Martins, E. C., Verissimo, M., & Martins, C. (2016). Does social-behavioral adjustment mediate the relation between executive function and academic readiness? Journal of Applied Developmental Psychology, 46, 22–30. https://doi.org/10.1016/j.appdev.2016.05.004 Bassett, H. H., Denham, S., Wyatt, T. M., & Warren-Khot, H. K. (2012). Refining the Preschool Self-regulation Assessment for Use in Preschool Classrooms. Infant and Child Development, 21(6), 596–616. https://doi.org/10.1002/icd.1763 Bell, M. A., & Wolfe, C. D. (2004). Emotion and Cognition: An Intricately Bound Developmental Process. Child Development, 75(2), 366–370. https://doi.org/10.1111/j.1467-8624.2004.00679.x Bocknek, E. L., Brophy-Herb, H. E., Fitzgerald, H., Burns-Jager, K., & Carolan, M. T. (2012). Maternal Psychological Absence and Toddlers’ Social-Emotional Development: Interpretations From the Perspective of Boundary Ambiguity Theory. Family Process, 51(4), 527–541. https://doi.org/10.1111/j.1545-5300.2012.01411.x Brock, R. L., & Kochanska, G. (2019). Anger in infancy and its implications: History of attachment in mother–child and father–child relationships as a moderator of risk. Development and Psychopathology, 31(04), 1353–1366. https://doi.org/10.1017/S0954579418000780 Cacioppo, J. T., & Berntson, G. G. (2019). The Affect System structure: architecture and operating characteristics. 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The paper presents research findings with 56 Roma children from Macedonia and Serbia between the ages of 3-6 years. The children’s knowledge of Romani as their mother tongue was assessed with a specially designed test. The test measures the children’s comprehension and production of different types of grammatical knowledge such as wh–questions, wh-complements, passive verbs, possessives, tense, aspect, the ability of the children to learn new nouns and new adjectives, and repetition of sentences. In addition, two pictured narratives about Theory of Mind were given to the children. The hypothesis of the authors was that knowledge of the complex grammatical categories by children will help them to understand better the Theory of Mind stories. The results show that Roma children by the age of 5 know most of the grammatical categories in their mother tongue and most of them understand Theory of Mind. References Bakalar, P. (2004). The IQ of Gypsies in Central Europe. The Mankind Quarterly, XLIV, (3&4), 291-300. Bedore L.M., Peña E.D., García, M. & Cortez, C. (2012). Conceptual versus monolingual scoring: when does it make a difference? J Speech Lang Hear Res 55(1), 1-15. Berko, J. (1958). The Child's Learning of English Morphology. Word 14, 150-177. Berman, R. & Slobin, D. (2009). Relating Events in Narrative: A Cross-Linguistic developmental Study, vol. 1. New York and London: Psychology Press. Bialystok, E. (2001). Bilingualism in development: Language literacy and cognition. Cambridge University Press: Cambridge. Bialystok, E. & Craik, F. (2010). Cognitive and Linguistic processing in the bilingual mind. Current Directions in Psychological Science, 19, (1), 19-23. Bialystok, E., Craik, F., and Freedman, M. (2007). Bilingualism as a protection against the onset of symptoms of dementia. Neuropsychologia, 45, 459-464. Brucker, J. L. (n.d). 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Lorenzo Suarez & F. Ramallo (Eds.), Bilingualism and Education: From the Family to the School. Muenchen: Lincom Europa. (pp. 161-168) Kyuchukov, H. (2010) Romani language competence. In: J. Balvin and L. Kwadrants (Eds.), Situation of Roma Minority in Czech, Hungary, Poland and Slovakia (pp. 427-465). Wroclaw: Prom. Kyuchukov, H. (2014). Acquisition of Romani in a Bilingual Context. Psychology of Language and Communication, vol. 18 (3), 211-225. Kyuchukov, H. (2013). Romani language education and identity among the Roma children in European context. In: J. Balvin, L. Kwadrans and H. Kyuchukov (eds) Roma in Visegrad Countries: History, Culture, Social Integration, Social work and Education (pp. 465-471). Wroclaw: Prom. Kyuchukov, H. (2015). Socialization of Roma children through Roma oral culture. In: Socializaciya rastushego cheloveka v kontekste progressyivnyih nauchnich ideii XXI veka: socialnoe razvitie detey doshkolnogo vozrastta. 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The achievement of family well - being is an aspiration of all families including families of migrant workers, to achieve the well - being of one of the ways that the families of migrant workers with the departure of the wife work as domestic servants in various countries. The purpose of this study was to analyze social capital, economic coping, sress symptom’s husband and family subjektive well - being of women migrant workers. This research use cross sectional studies. The location was chosen purposively in Tanggeung Village, Pagermaneuh Village, Margaluyu Village, Karangtengah Village, Tanggeung District and Pasirdalam Village Kadupandak District, Cianjur, West Java, Indonesia. Seventy five families were selected purposively among the families of women migrant workers. The finding indicates that social capital is in the moderate category, the coping economy is in the moderate category, the sress symptom’s husband is in the low category and the family well-being is in the low category. Finding in this study family subjective well-being is influenced by income per capita, sress symptom’s husband and economic coping. Keywords: economic coping, family subjective well-being, social capital, stress symptom Abstrak Kesejahteraan keluarga merupakan sesuatu yang ingin dicapai seluruh keluarga, termasuk keluarga Tenaga Kerja Wanita (TKW), untuk mencapai kesejahteraan tersebut salah satu cara yang dilakukan oleh keluarga TKW adalah mengirim istri sebagai pembantu rumah tangga di berbagai negara. Tujuan dari penelitian ini adalah untuk menganalisis modal sosial, coping ekonomi, gejala stres suami, dan kesejahteraan subjektif keluarga TKW. Penelitian ini menggunakan cross sectional studies. Lokasi dipilih dengan metode purposive di Provinsi Jawa Barat, Kabupaten Cianjur, Kecamatan Tanggeung, Desa Pagermaneuh, Desa Marguluyu, Desa Karangtengah, Desa Tanggeung, Kecamatan Kadupandak, Desa Pasirdalam. Jumlah sampel sebanyak 75 keluarga TKW dengan metode purposive sampling. Penelitian ini menemukan modal sosial berada pada kategori sedang, coping ekonomi berada pada kategori sedang, gelaja stres suami berada pada kategori rendah, dan kesejahteraan subjektif berada pada kategori rendah. Penelitian ini juga menemukan kesejahteraan keluarga berpengaruh terhadap pendapatan perkapita, gelaja stres suami, dan coping ekonomi. Kata kunci : coping ekonomi, gejala stres, kesejahteraan subjektif, modal sosial. References [BPS] Badan Pusat Statistik. 2016. Data provinsi termiskin 2016. Berita Resmi Statistik [internet]. 4 Januari 2016. [diunduh 2016 September 7]; Tersedia pada: http://www.bps.go.id. [BPS] Badan Pusat Statistik Jawa Barat. 2016. Garis Kemiskinan Menurut Kabupaten/Kota di Jawa Barat (Rp/kapita/bulan), 2005-2014. Berita Resmi Statistik [internet]. 4 Januari 2016, [diunduh 2016 September 7]; Tersedia pada: http://jabar.bps.go.id. Alfiasari. 2008. Analisis modal sosial dalam pemberdayaan ekonomi keluarga miskin di Kelurahan Kedung Jaya, Kecamatan Tanah Sareal, Kota Bogor. Vol. 1 no. 1 edisi Januari. Bogor (ID): Institut Pertanian Bogor. Borner, Shively J, Wunder G, Wyman S. 2012. How do rural households respond to economic shocks? Insights from hierarchical analysis using global data. International Association of Agricultural Economists. Casey L. 2013. Stress and wellbeing in Australia survey 2013. Australian Psychological Society Carbonell A F. 2005. Income and well-being: an empirical analysis of the comparison income effect. Journal of Public Economics: 89 (2005) 997 – 1019. Coleman J S. 1988. “Social capital in the creation of human capital.” American Journal of Sociology 94 (Supplement): S95-S120. 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Changes in Consumption and Saving Behavior before and after Economic Shocks: Evidence from Zimbabwe. http://www.jstor.org/stable/10.1086/380136 Fujiwara F, Kawachi I. 2008. Social Capital and Health A Study of Adult Twins in the U.S. American Journal of Preventive Medicine. Vol. 35: 2 Garcia M, McDowell T. 2010. Mapping Social Capital: A Critical Contextual Approach For Working with Low-Status Families. Journal of Marital and Family Therapy. Vol. 36 No. 1: 96. 10.1111/j.1752-0606.2009.00188.x Grootaert C. 1999. Social capital, household walfare and poverty in Indonesia. Working Paper, No.6. Washington DC, USA: The World Bank. Social Development Department. Hasanah U, Nadiroh, Neolaka A. 2017. The Influence of Couple Interaction, Roles Differences, and Social-Economic Status on Mother’s Stress Coping. American Scientific Publisher. Vol. 23 10868 – 10870. Helliwell J F, Huang H, Wang S. 2013. Social Capital and Well-Being in Times of Crisis. 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National Centre for Epidemiology and Population Health, The Australian National University Wills E, Orozco L, Forero C, Pardo O, Andonova V. 2011. The relationship between perceptions of insecurity, social capital and subjective well-being: Empirical evidences from areas of rural conflict in Colombia. The Journal of Socio-Economics. Vol. 40 88–96 Yip W, Subramanian S. V, Mitchell A D, Lee D, Wang J, Kawachi I. 2007. Does social capital enhance health and well-being? Evidence from rural China. Journal Social Science & Medicine: 35 – 49

Recently a monograph appeared dealing with Roman epigraphical monuments from the West-Serbian town of Cacak and its neighbourhood (S. Ferjancic / G. Jeremic / A. Gojgic, Roman Epigraphic Monuments from Cacak and its Vicinity Cacak 2008, Engl. Summary pp. 103-107). Authored by one specialist in Roman history and epigraphy and two archaeologists, the book is rather thin and does not provide much new data, apart from the identification of the equestrian officer Tiberius Claudius Gallus with Severus' senator - which was taken from my PhD thesis without citing it - and from two inscriptions, ? 20 and ? 21, forming the subject of the present paper. Published here for the first time, they both contain important information which the co-authors failed to notice. The consuls of 227 A.D. in an inscription from Cacak The ? 21 (fig. 1) was found in the site of Gradina on the mountain Jelica, S. of Cacak. It is engraved on a whitish limestone monument, apparently an ara, the middle and lower parts of which are preserved after it has been reshaped to be used as building material. The four-line inscription was read by the editors as follows: [- - -] Aur(elius) F[- - - v(otum)] l(ibens) p(osuit) Mal+[- - -]et Al[- - - co(n)s(ulibus)] Idibus [- - -]. Unable to identify the pair of consuls mentioned in lines two and three, the authors interpret the inscription as a funerary one: [- - -]Aur(elius or -elio) F[- - - vix(it) ann(is)] L P. Mal+[- - -]et Al[- - - f(ecerunt) ? die ?] Idibus [- - -]. In fact, they misread the final cluster of the line two, by having mistaken for L the long right serif of M (in ligature with A) together with a trace of a subsequent letter, which proves to be an X. The alignment of the letters at the beginning of the lines suggests that the left side of the inscription is entirely preserved. The inscription reads as folows: ] \ Aur(elius) F+[ -] \ l(ibens) p(osuit) Max[imo] \ et Al[bino co(n)s(ulibus)] \ Idibus [ -]. M. Laelius Maximus Aemilianus (PIR2 L56) - probably son of Marcus Laelius Maximus (PIR2 L55), one of the leading senators under Septimius Severus - and M. Nummius Senecio Albinus (PIR2 N235) were the eponymous consuls of 227. The pair is attested in several inscriptions, e.g. CIL VIII 18831 from Numidia which resembles this one in recording the exact date: Bacaci Aug(usto) \ sac(rum) \ Albino et Ma\ximo co(n)s(ulibus) \ Kal(endis) Mai(is) [3] Si\ttius Novellus \ et Q. Galerius Mu\stianus magg(istri) \ [Thib(ilitanorum?)]. Here Albinus' name precedes that of Maximus, which is usually the case. Nevertheless, a parallel with Maximus named before Albinus is provided by an inscription from Dacia (ILD 774, near Cluj): Deae Ne\mesi sac\rum Aur(elius) Ru[f]inus \ be(ne)f(iciarius) co(n)s(ularis) \ leg(ionis) XIII Gem(inae) \ Sever(ianae) v(otum) l(ibens) p(osuit) Maximo et Albi\[no] co(n)s(ulibus). Consequently, ? 21 is a votive inscription, largely restorable and precisely datable. The Collegium curatorum of the Cohors II Delmatarum in an inscription from Cacak Forty years ago within the Ascension Church yard in Cacak the lower part of a Roman limestone monument has been accidentally unearthed, bearing an inscription, three last lines of which are partially preserved (? 20 of the catalogue, (fig. 2), wherein only the mention of a cohort was recognized by the editors, who read: ]\[- - -]ALB[- - -| -]GIATI +[- - -|- - -co]h(ortis) eiusde(m) [- - -|- - - The elegant, shaded letters are lined up one below the other, which suggests that the text was arranged following the principle of centering. Above the L in the first line there is a trace of an O or a Q, unnoticed by the editors. So, there are 4 lines partially preserved. The space left between the lines 2 and 3 being larger than that between 1-2 and 3-4 respectively, the two last lines seem to constitute a separate entry. The genitive case cohortis eiusdem implies a preceding designation of the dedicant(s), and what we have before is a nominative plural ending in ?giati followed by a word of which only the first letter, C or O, is still discernible. As the most probable, if not the only possible, we propose the following restoration of the last two lines (fig. 8): [colle]giati c[urat(ores)]|[co]h(ortis) eiusde[m] possibly with a p(osuerunt) or d(edicaverunt) in the end. Despite its fragmentariness, the present inscription bears an important testimony to the existence, within the Roman army, of professional associations (collegia militaria) independent of regular military structures. The evidence for them is based solely on epigraphic sources; some hundred inscriptions contradict the paragraph of the Digesta (47.22) forbidding the soldiers to organize corporate associations in the camps. The cohort in question is doubtless the cohors II Aurelia Delmatarum milliaria equitata, which is known to have been stationed permanently, from the seventies of the second century A.D. to the fifties of the third century, in the eastern part of Dalmatia around the modern city of Cacak. It was a mixed infantry and cavalry unit, and the rank of curator (curator equitum singularium, curator alae, curator cohortis) is attested exclusively in the mounted units of the Roman army. It was higher than the simple eques; in the auxiliary troops, the curators may have been charged with special tactical or economic-administrative tasks. The lower officers (principales) and the soldiers with special tasks were allowed to form private associations fostering loyalty to the Emperor. All Roman collegia including the military ones, had their religious purpose and their official meeting room (schola) was also a sanctuary of their patron deity. It might be a part of the headquarters building, as in the case of the Castra Nova equitum singularium in Rome, where, beneath the Basilica of St John Lateran an Ionic capitel was uncovered with inscription on it dated with AD 197 recording the dedication of the schola curatorum to Minerva Augusta (AE 1935 156 = AE 1968, 8b).

Hydrogen peroxide (H2O2) has emerged as a chemical of paramount importance, finding diverse applications as a bleaching agent, medical disinfectant, and environmentally benign oxidant [1]. The industrial production of H2O2 currently relies on the anthraquinone oxidation process, primarily executed within large-scale industrial plants [1]. Herein lies a challenge— H2O2, typically concentrated to an 80% level, introduces inherent hazards concerning storage and transportation, prompting a quest for a safer alternative. One way to overcome such problems is by the in-situ electrogeneration of H2O2, which would allow an adjustable production of the chemical on demand directly for its application, avoiding storing costs and safety issues. The in-situ electrogeneration can be done by using a gaseous-diffusion electrode (GDE), which typically enables the application of elevated current densities or substantial overpotentials, consequently facilitating the generation of high concentrations of H2O2, since there is less limitation due to O2 mass transport to the electrode surface [2]. Commonly, these electrodes are constructed from amorphous carbon materials, due to their highly active surface area with oxygenated functional groups, excellent conductivity, and innate selectivity for H2O2 electroproduction. However, a notable challenge emerges – bare carbon's selectivity for H2O2 presents its highest response at high overpotentials, entailing heightened energy consumption. The studies in this field are currently focused on using these types of carbon as support for other catalytic materials that are more active and selective towards H2O2 electroproduction [3, 4]. Numerous studies in the literature have explored the use of carbon materials, with the most commonly employed carbon supports for such applications being Printex 6L (Orion) and Vulcan XC 72R (Cabot). These materials are obtained from the incomplete combustion of heavy petroleum products at high temperatures, being non-sustainable and environmentally unfriendly. A potential solution lies in the use of environmentally conscious carbon sources. While amorphous carbon can be obtained from various carbon-rich wastes through an activation process, their utility in H2O2 electrogeneration remains underexplored. This study sought to obtain activated carbon from sewage sludge, focusing on its efficacy in H2O2 electrogeneration. Acid (H3PO4) and alkaline (KOH/NaOH mixture) carbon activators were analyzed in concentrations ranging from 0 – 30 %m/v, temperatures of 400 – 900 ºC, and activation time from 0 – 2 h at the selected temperature. The obtained materials were analyzed through linear sweep voltammetry using an RRDE setup in N2-saturated and O2-saturated, in a 0.05 M K2SO4 (pH 3) electrolyte solution. Results have shown that the most successful materials for H2O2 electrogeneration were those produced under 900 ºC for 2h impregnated with 5 % m/v H3PO4 and 597 ºC, zero of plateau time impregnated with 20 % m/V mixture of KOH/NaOH in the ratio of 50.5 KOH: NaOH. These optimized materials exhibited remarkable selectivities of ≈ 90% and ≈ 81% at -0.8 V vs. Ag/AgCl, respectively. This level of electrocatalytic performance is on par with that of the commercial reference material, Printex 6L. These findings highlight the promise of our material as a viable carbon support for in-situ H2O2 electrogeneration, offering a more sustainable alternative compared to commercial black carbons. Acknowledgments The authors are sincerely grateful to the Brazilian research funding agencies, including the Brazilian National Council for Scientific and Technological Development - CNPq (grants no. 465571/2014-0, 302874/2017-8, and 427452/2018-0), São Paulo Research Foundation (FAPESP – grants no. #2023/04230-2, #2023/07750-7, 2022/04058-2, #2021/12053-8, #2019/04421-7, #2017/10118-0, and #2013/02762-5). References [1] S. Li, J. Ma, F. Xu, L. Wei, D. He, Fundamental principles and environmental applications of electrochemical hydrogen peroxide production: A review, Chemical Engineering Journal, 452 (2023) 139371. [2] A. Francisco, B. Enric, C. Pere-Llui's, Oxygen Reduction on Uncatalyzed Carbon-\ PTFE\ Gas Diffusion Cathode in Alkaline Medium, Journal of The Electrochemical Society, 149 (2002) E64 , publisher = The Electrochemical Society. [3] G.V. Fortunato, E. Pizzutilo, A.M. Mingers, O. Kasian, S. Cherevko, E.S.F. Cardoso, K.J.J. Mayrhofer, G. Maia, M. Ledendecker, Impact of Palladium Loading and Interparticle Distance on the Selectivity for the Oxygen Reduction Reaction toward Hydrogen Peroxide, The Journal of Physical Chemistry C, 122 (2018) 15878-15885. [4] L.C. Trevelin, R.B. Valim, J.C. Lourenço, A. De Siervo, R.S. Rocha, M.R.V. Lanza, Using ZrNb and ZrMo oxide nanoparticles as catalytic activity boosters supported on Printex L6 carbon for H2O2 production, Advanced Powder Technology, 34 (2023) 104108. Figure 1

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ABSTRAK Penurunan profit bisnis kecil akibat implikasi ekonomi pasca pandemi COVID-19. Persoalan struktur permodalan menjadi kendala dalam mempertahankan dan meningkatkan usahanya secara terus menerus seiring kerubahan zaman. Koperasi Syariah sebagai salah satu lembaga keuangan Islam yang keislaman lebih dekat secara eksistensi maupun teritorial dengan masyarakat tingkat bawah sehingga menjadi alternatif pengembangan usaha masyarakat secara syariah sesuai persyaratan yang diberikan. Studi ini bertujuan untuk untuk menganalisis pengaruh literasi keuangan syariah dalam sikap, pengaruh sosial dan self-efficacy terhadap perilaku pemanfaatan produk koperasi syariah di Indonesia. Studi kuantitatif survey online dengan melibatkan 280 calon anggota koperasi syariah yang membutuhkan pembiayaan dan merupakan pemilik UMKM dijalankan dengan teknik analisis SEM PLS. Hasil studi menunjukkan pengaruh literasi keuangan terhadap sikap, pengaruh sosial dan self-efficacy lalu dilanjutkan arah jalur dukungan hipotesis terhadap niat untuk memilih Koperasi Syariah sebagai solusi kebutuhan finansial UMKM ditemukan. Strategi manajerial khususnya pemasaran dikembangkan dengan mempertimbangkan efek sikap positif, pengaruh sosial dan efikasi diri calon anggota sebagai pemilik bisnis atau produk keuangan syariah yang akan mereka tawarkan kepada pelanggan mereka akan berkontribusi pada pertumbuhan sektor UMKM khususnya UMKM Generasi Millenial dan UMKM Hijau di Indonesia melalui upaya promosi dan kerjasama. Kata Kunci: ASE Model, Ekonomi Islam, Koperasi Syariah, Pemberdayaan, UMKM. ABSTRACT The decline in small business profits due to the post-COVID-19 pandemic economy. The issue of capital structure is an obstacle in maintaining and increasing development continuously in line with the changing times. Sharia cooperatives as one of the Islamic financial institutions are closer in existence and territorially to the lower level of society so that they become an alternative for community business development in accordance with the requirements given. This study aims to analyze the effect of Islamic financial literacy on attitudes, social influence and self-efficacy on the application of Islamic cooperative products in Indonesia. Quantitative study of online surveys involving 280 prospective members of Islamic cooperatives who need financing and are MSME owners carried out with the PLS SEM analysis technique. The results of the study show the effect of financial literacy on attitudes, social influence and self-efficacy, then choosing the direction of hypothesis support for the intention to find Islamic Cooperatives as a solution to the financial needs of MSMEs. Managerial strategies especially marketing that are developed taking into account the effects of positive attitudes, social influence and self-efficacy of prospective members as owners or Islamic financial products that they will offer to their customers will increase the growth of the MSME sector, especially Millennial Generation MSMEs and Green MSMEs in Indonesia through promotional efforts and cooperation. Keywords: ASE Model, Islamic Economics, Sharia Cooperatives, Empowerment, MSMEs. REFERENCES Abourrig, A. (2021). Social influence in predicting Islamic banking acceptance: Evidence from Morocco. International Journal of Accounting, Finance, Auditing, 2(2), 42–56. https://doi.org/10.5281/zenodo.4641472 Ajzen, I. (1991a). The theory of planned behavior. Organizational Behavior and Human Decision Processes, 50(2), 179–211. https://doi.org/10.1016/0749-5978(91)90020-T Ajzen, I. (1991b). The theory of planned behavior. 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Child Distance Learning (CDL) during the pandemic has led to an optimal development of children and effective teaching and learning processes in kindergartens. To overcome this, teachers need to apply a teaching approach in accordance with the principles of kindergarten education. In addition, teachers' self-efficacy of their ability to teach is also important for developing children's skills. This study aims to describe the teaching approach and the efficacy of kindergarten teachers during the CDL process and to identify the relationship between the two. The research method used is quantitative through document analysis as a source of data findings. A total of 116 Public Kindergarten (PK) teachers in DKI Jakarta participated in filling out the Classroom Management Scale and Teachers' Sense of Efficacy Scale online. All data were processed using descriptive statistics and correlation. Furthermore, there is a document analysis carried out on the Daily / Weekly Learning Program Design in PK Jakarta. The findings identified that the teaching approach of kindergarten teachers during CDL included only two principles of kindergarten education, namely thematic teaching and developing life skills. Furthermore, PK teachers in the Jakarta area showed low self-efficacy during CDL. The teaching approach and self-efficacy were caused by teachers' unpreparedness in facing challenges during CDL. In addition, other findings indicate that there is a relationship between teaching approaches and teacher self-efficacy. Another CDL model Interventions to increase teacher self-efficacy and the extent to which the relationship between the two variables can be studied further in future studies. Keywords: Early Childhood, Distance Learning, Teaching Approach, Teacher Self-Efficacy References: Agustin, M., & Wahyudin, U. (2011). Penilaian perkembangan anak usia dini. Refika Aditama. 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Imaging buried geological boundaries is one of a major objective during the interpretation of magnetic field data in Geophysics. Therefore, edge detection and edge enhancement techniques assist a crucial role on this aim. Most of the existing edge detector methods require to obtain special points such as in general the maxima of the resulting image. One of the useful tools in estimating edges from magnetic data is the tilt angle of the analytical signal amplitude due to its value slightly dependence on the direction of magnetization. In this study, the maxima of the tilt angle of analytical signal amplitudes of the magnetic data was determined by a curvature-based method. The technique is based on fitting a quadratic surface over a 3×3 windows of the grid for locating any appropriate critical point that is near the centre of the window. The algorithm is built in Matlab environment. The feasibility of the algorithm is demonstrated in two cases of synthetic data as well as on real magnetic data from Tu Chinh-Vung May area. The source code is available from the authors on request.ReferencesAkpınar Z., Gürsoy H., Tatar O., Büyüksaraç A., Koçbulut F., Piper, JDA., 2016. Geophysical analysis of fault geometry and volcanic activity in the Erzincan Basin, Central Turkey, Complex evolution of a mature pull-apart basin. Journal of Asian Earth Sciences, 116, 97-114. Beiki M., 2010. Analytic signals of gravity gradient tensor and their application to estimate source location, Geophysics, 75(6), 159-174.Blakely R. J., and Simpson R.W., 1986. Approximating edges of source bodies from magnetic or gravity anomalies, Geophysics, 51, 1494-1498.Chen An-Guo, Zhou Tao-Fa, Liu Dong-Jia, Zhang Shu, 2017. Application of an enhanced theta-based filter for potential field edge detection: a case study of the LUZONG ORE DISTRICT, Chinese Journal of Geophysics, 60(2), 203-218.Cooper G.RJ., 2014. Reducing the dependence of the analytic signal amplitude of aeromagnetic data on the source vector direction, Geophysics, 79, 55-60.Cordell L., 1979. Gravimetric Expression of Graben Faulting in Santa Fe Country and theEspanola Basin, New Mexico. In Ingersoll, R.V., Ed., Guidebook to Santa Fe Country, New Mexico Geological Society, Socorro, 59-64.Cordell L and Grauch V.J.S., 1985. Mapping Basement Magnetization Zones from Aeromagnetic Data in the San Juan Basin, New Mexico, The Utility of Regional Gravity and Magnetic Anomaly Maps, Society of Exploration Geophysicists, Tulsa, 181-197.Hsu S.K., Coppense D., Shyu C.T., 1996. High- resolution detection of geologic boundaries from potential field anomalies: An enhanced analytic signal technique, Geophysics, 61, 1947-1957.Le D.C., Application of seismic exploration methods to identify geological structural characteristics supporting for hydrocarbon potential assessment in TuChinh - Vung May basin, Ph.D. Thesis, Hanoi University of Mining and Geology.Li X., 2006. Understanding 3D analytic signal amplitude: Geophysics, 71(2), 13-16.Miller H.G. and Singh V., 1994. Potential Field Tilt a New Concept for Location of Potential Field Sources, Journal of Applied Geophysics, 32, 213-217.Nabighian M.N., 1972. The analytic signal of two-dimensional magnetic bodies with polygonal cross-section: Its properties and use of automated anomaly interpretation, Geophysics, 37, 507-517.Nguyen N.T., Bui V.N., Nguyen T.T.H., 2014. Determining the depth to the magnetic basement and fault systems in Tu Chinh - Vung May area by magnetic data interpretation, Journal of Marine Science and Technology, 14(4a), 16-25.Nguyen X.H, San T.N, Bae W., Hoang M.C, 2014. Formation mechanism and petroleum system of tertiary sedimentary basins, offshore Vietnam, Energy Sources, Part A, 36, 1634-1649.Phillips J.D., Hansen R.O. and Blakely R.J., 2007. The use of curvature in potential-field interpretation, Exploration Geophysics, 38(2), 111-119.Rao D.B., and Babu N.R., 1991. A rapid method for three-dimensional modeling of magnetic anomalies, Geophysics, 56(11), 1729-1737.Roest W.R., Verhoef J., and Pilkington M., 1992. Magnetic interpretation using the 3-D analytic signal, Geophysics, 57, 116-125.Tran N., 2017. Sediment geology of Vietnam, VNU Press.Tran T.D., Tran N., Nguyen T.H., Dinh X.T., Pham B.N., Nguyen T.T., Tran T.T.T.N., Nguyen T.H.T., 2018. The Miocenedepositional geological evolution of Phu Khanh, Nam Con Son and Tu Chinh - Vung May basins in Vietnam continental shelf, VNU Journal of Science: Earth and Environmental Sciences, 34(1), 112-135.Vo T.S., Le H.M., Luu V.H., 2005. Three-dimensional analytic signal method and its application in interpretation of aeromagnetic anomaly maps in the Tuan Giao region, Proceedings of the 4th geophysical scientific and technical conference of Vietnam, Publisher of Science and Engineering 2005.Wijns C, Perez C and Kowalczyk P, 2005, Theta map: Edge detection in magnetic data, Geophysics, 70, 39-43.

Abstract: The main problem of this research is the Government's Strategy to Increase Community Economic Empowerment in the Bara Subdistrict of Palopo City with the following problems: 1. What is the socio-economic condition of the Bara sub-district community? 2. What is the government's strategy in empowering the community of Bara sub-district? 3. How does the impact of government empowerment on economic improvement? This research aims: a. To find out and analyze socioeconomic conditions b. To find out and analyze the government's strategy in increasing community empowerment in Bara sub-district c. To find out and analyze the impact of government empowerment on economic improvement. To obtain data, the authors use the field research and library research methods which then analyze the data using qualitative methods then draw conclusions with analysis techniques (SWOT) Strengths Weaknesses Opportunities and Threats. Based on the results of the study show that: 1. In developing the community economy in the District of Bara by seeing the efforts made by the government to increase the potential for every community is very positive response to the government's efforts to motivate the community to be able to develop in addition to being a good training , the community will be considered capable of increasing the potential and opportunities in the community's economy. 2. With the strategy carried out by the government through business assistance, it is very proven that the business is able to increase the level of income for the community while the businesses that have been implemented include: the business of selling stalls, selling chips, fish selling businesses, sewing machine businesses, vegetable farming businesses , the business of a thousand chicken coops, and workshop business. 3. An increase in business in empowering the community has a very positive impact and the government is considered capable of improving the welfare of the community so that business assistance carried out by the government can change every community's life towards a better one. Keywords: Government Strategy, Efforts to Increase Community Economic Empowerment. Abstrak: Permasalahan pokok penelitian ini adalah tentang Strategi Pemerintah dalam Upaya Meningkatkan Pemberdayaan Ekonomi Masyarakat di Kecamatan Bara Kota Palopo dengan masalah sebagai berikut: 1. Bagaimana kondisi sosial ekonomi masyarakat kecamatan bara? 2. Bagaimanakah strategi pemerintah dalam pemberdayaan masyarakat kecamatan bara? 3. Bagaimana dampak pemberdayaan pemerintah terhadap peningkatan ekonomi?.Penelitian ini bertujuan: a. Untuk mengetahui dan menganalisis kondisi sosial ekonomi b. Untuk mengetahui dan menganalisis strategi pemerintah dalam meningkatkan pemberdayaan masyarakat di kecamatan bara c. Untuk mengetahui dan menganalisis dampak pemberdayaan pemerintah terhadap peningkatan ekonomi. Untuk memperoleh data, penulis menggunakan metode field research dan library research yang kemudian menganalisa data dengan menggunakan cara kualitatif kemudian mengambil kesimpulan dengan teknik analisis (SWOT) Strengths (Kekuatan) Weaknesses (Kelemahan) Opportunities (Peluang) dan Threats (Ancaman). Berdasarkan hasil penelitian menunjukkan bahwa: 1. Dalam membangun perekonomian masyarakat yang ada di Kecamatan Bara dengan melihat adanya upaya yang dilakukan pemerintah untuk meningkatkan potensi bagi setiap masyarakat sangatlah memberikan respon positif dengan adanya usaha pemerintah dapat memotivasi masyarakat untuk mampu berkembang disamping dapat menjadi pelatihan yang baik, masyarakat akan dianggap mampu untuk meningkatkan potensi dan peluang dalam ekonomi masyarakat. 2. Dengan adanya strategi yang dilakukan pemerintah melalui bantuan usaha sangat terbukti bahwa usaha tersebut mampu untuk menambah tingkat pendapatan bagi masyarakat adapun usaha yang sudah terlaksana diantaranya yaitu: usaha warung jualan, usaha penjualan keripik, usaha penjualan ikan, usaha mesin jahit, usaha petani sayur, usaha seribu kandang ayam, dan usaha perbengkelan. 3. Adanya peningkatan usaha dalam memberdayakan masyarakat sangat berdampak positif dan pemerintah dianggap mampu dalam meningkatkan kesejahteraan masyarakat sehingga bantuan usaha yang dilakukan pemerintah dapat merubah setiap kehidupan masyarakat kearah yang lebih baik. Kata Kunci : Strategi Pemerintah, Upaya Meningkatkan Pemberdayaan Ekonomi Masyarakat. Daftar Pustaka Abdad M. 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The paper presents an improved algorithm based on Bhaskara Rao and Ramesh Babu’s algorithm to invert magnetic anomalies of three-dimensional basement structures. The magnetic basement is approximated by an ensemble of juxtaposed vertical prisms whose bottom surface coincides with Curie surface with the known depth. The computer program operating with the proposed algorithm is built in Matlab environment. Test applications show that the proposed method can perform computations with fast and stable convergence rate where the results also coincide well with the actual model structure. The effectiveness of the method is demonstrated by inverting magnetic anomalies of the southeast part of Vietnam continental shelf. The calculated magnetic basement relief of the study area provides useful additional information for studies in the aim of dealing with the geological structure of the area.References Beiki M., 2010. Analytic signals of gravity gradient tensor and their application to estimate source location, Geophysics, 75(6), i59–i74.Bui C.Q. (chief author), Le T., Tran T. D., Nguyen T. H., Phi T.T., 2007. Map of deep structure of the Earth’s crust, Atlas of the characteristics of natural conditions and environment in Vietnam’s waters and adjacent region. Publisher of Science and Technology, Ha Noi. Do D.T., Nguyen T.T.H., 2011. Atempt the improvement of inversion of magnetic anomalies of two dimensional polygonal cross sections to determine the depth of magnetic basement in some data profile of middle off shelf of Vietnam. Journal of Science and Technology, Vietnam Academy of Science and Technology, 49(2), 125–132.Do D.T., 2013. Study for application of 3D magnetic and gravity method to determine density contribution of basement rock and depth of magnetic basement on Vietnam’s shelf for oil research and prospecting Vietnam National University, Hanoi, Project code QG-11-04. 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Application of power density spectrum of magnetic anomaly to estimate the structure of magnetic layer of the earth crust in the Bac Bo gulf. Journal of Marine Science and Technology, 14(4A), 137–148.Nguyen N.T., Bui V.N., Nguyen T.T.H., 2014b. Determining the depth to the magnetic basementand fault systems in Tu Chinh - Vung May area by magnetic data interpretation. Journal of Marine Science and Technology, 14(4A), 16–25.Nguyen T.T.H., Pham T.L., Do D.T., Le H.M., 2018. Improving algorithm of determining the coordinates of the vertices of the polygon to invert magnetic anomalies of two-dimensional basement structures in space domain, Journal of Marine Science and Technology (preparing to print).Parker R.L., 1973. The rapid calculation of potential anomalies, Geophys. J. Roy. Astron. Soc, 31, 447–455. Pilkington M., Gregotski M.E., Todoeschuck J.P., 1994. Using fractal crustal magnetization models in magnetic interpretation, Geophysical Prospecting, 42, 677–692.Pilkington M., 2006. 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The enthusiasm in the Tahfidz House (TH) education program especially for children shows an increasing trend in Padang, a modeling city in developing Islāmic character for children. The purpose of this study was to investigate the Tahfidz House program trends development in early childhood in Padang. This study uses qualitative methods with data collection tools, namely inter- views, direct observation, and document analysis. The results showed that: First, the Tahfidz House program attracted public interest because it offered dimensions of character formation such as in- creasing Intelligence Quotient, Emotional Quotient, and Spiritual Quotient. Second, there is a theo- logical reason in the landscape of local people to think that the Qur'an offers a blessing concept in our lives. Third, Tahfidz House existences as non-formal education has two dominant affiliations, namely pure education and based on market interests or capitalization. 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The article listed below, published in journal Genetika has been retracted due to evidence indicating that the peer review of this paper was compromised, using of frauted data, high number of unfitting citation, overoll general misconduct related to professional codes of ethics. All papers which belong to this group have passed a regular review process. As part of the reviewing process, according to Journal policy, it is expected from reviewers to check all relevant data including citations probity. All papers were published after two positive reviewers? opinions. The journal Genetika condemns such an unethical behavior and will take all necessary measures to ensure that such incidents do not happen again in the future. Authors of those papers as well reviewers are barred from publishing in the journal Genetika in the future and will be blacklisted by the journal. The list of retracted articles is: 1. Bouzarisaravani Z., F. Sharifnia, F. Salimpour, S. Arbabian, A. Geran (2021). Molecular systematic studies in the genus Glaucium (Papaveraceae). - Genetika, Vol 53, No.3, 1179-1192 https://doi.org/10.2298/GENSR2103179B 2. Hang L., L. Pan, T. Yong, L. Jianguo, X. Xingmin, Faisal (2021). Population genetic structure and gene flow in Alcea aucheri (boiss.) Alef.: a potential medicinal plant- Genetika, Vol 53, No.2, 867-882. https://doi.org/10.2298/GENSR2102867H 3. Jiao L., H. Xiao, X. Zhao, F. M. Abarghuei (2021). RAPD profiling in detecting genetic variation in Glaucium (Papaveraceae) species: Edible and Medicinal plant. - Genetika, Vol 53, No.3,1081 - 1092. https://doi.org/10.2298/GENSR2103081J 4. Li H., H. Yu, X. Zeng, S. Hussein Hamarashid (2021). Study on genetic diversity between Malva L. (Malvaceae): a high value medicinal plant using SCoT molecular markers.- Genetika, Vol 53, No.2, 895-910 https://doi.org/10.2298/GENSR2102895L 5. Li H., Y. Wang, R, Iqbal (2021). SCoT molecular markers and population differentiation in Hedera helix L.. - Genetika, Vol 53, No.2, 739-756. https://doi.org/10.2298/GENSR2102739L 6. Li J., X. Yang, S.Mehri (2021). Genetic diversity in Stellaria L. (Caryophyllaceae) using sequence related amplified polymorphism. - Genetika, Vol 53, No.3, 1369 - 1377. https://doi.org/10.2298/GENSR2103369L 7. Lin L., L. Lin, A.Waheed (2021). Assessment of genetic structure and diversity of Erodium (Geranaiceae) species. - Genetika, Vol 53, No.2, 507-520. https://doi.org/10.2298/GENSR2102507L 8. Li S. X. Jiang, S. Mehri (2021). Genetic diversity and gene-pool of Aegilops tauschii coss. (Poaceae) based on retrotransposon-based markers. - Genetika, Vol 53, No.3, 1331- 1340. https://doi.org/10.2298/GENSR2103331L 9. Ma X., H. Tian, H. Xia, Zeenat (2021). Genetic diversity of Lonicera L. (caprifoliaceae) estimated by molecular markers and morphological characters. - Genetika, Vol 53, No.2, 651-662. https://doi.org/10.2298/GENSR2102651M 10. Mahdavi M., F. Sharifnia, F.Salimpour, A. Esmaeili, M. Larypoor (2021). Genetic diversity and population structure of Iranian pistachio (Pistacia vera L.) cultivars.- Genetika, Vol 53, No.2, 671-686 https://doi.org/10.2298/GENSR2102671M 11. Meng K., J. Yao, C.Y. He and H. Morabbi Heravi (2021). Gene flow and genetic structure between populations of Hesperis L. (Brassicaceae) species using molecular markers. - Genetika, Vol 53, No.2, 769-782. https://doi.org/10.2298/GENSR2102769M 12. Mowang S.-C., F.-J. Chen, Zeenat (2021). Study on genetic diversity between Erodium (Geranaiceae) species based on inter-simple sequence repeat markers- Genetika, Vol 53, No.2, 927-939. https://doi.org/10.2298/GENSR2102837M 13. Najafian S., I.Mehregan, A. Iranbakhsh, M. Assadi, S. Fici (2021). Species delimitation in Capparis (Capparaceae): morphological and molecular. - Genetika, Vol 53, No.2, 609-627. https://doi.org/10.2298/GENSR2102609N name mark red not autors of paper (corrigentdum) 14. Nikkhah M., S. Arbabian, A. Majd, F. Sharifnia (2022). Genetic diversity of Cordia myxa L. assessed by ISSR markers. - Genetika, Vol 54, No.1, 63-72. https://doi.org/10.2298/GENSR2201063N 15. Ou C., Z. Shen, Y. Liu, Z. Wang, M. Farshadfar (2021). Morphometric analysis and genetic diversity in Pistacia species populations using sequence related amplified polymorphism. - Genetika, Vol 53, No.3, 1193-1205 https://doi.org/10.2298/GENSR2103193O 16. Qian X. and S. Mehri (2021). Detecting DNA polymorphism and genetic diversity in a wide pistachio germplasm by RAPD markers- Genetika, Vol 53, No.2, 783-798 https://doi.org/10.2298/GENSR2102783Q 17. Xu P.,C. Xu, X.Huang, H.Wang, H. Morabbi Heravi (2021). Genetic diversity and genepool of Salicornia sinus-persica akhani based on retrotransposon-based markers. - Genetika, Vol 53, No.3, 1287 - 1296.https://doi.org/10.2298/GENSR2103287X 18. Garshasbi S., A. Iranbakhsh, Y. Asri, S. Z. Bostanabad (2021). Genetic diversity and population structure analysis in Lonicera L. (Caprifoliaceae) with the use of ISSR molecular markers. - Genetika, Vol 53, No.3, 1273 - 1286 https://doi.org/10.2298/GENSR2103273G name mark red not autors of paper (corrigentdum) 19. Sun Y., H. Jiang, F. Zeng, X. Pan, X. Wu, Y. Qi, X. Wu (2022). Species identification and genetic diversity of Alcea (Malvaceae) using SCOT molecular markers: medicinal plant. - Genetika, Vol 54, No.1, 369-378. https://doi.org/10.2298/GENSR2201369S 20. Ting S. and Y. Yibing (2022). Population differentiation and gene flow of Glaucium flavum (Papaveraceae). - Genetika, Vol 54, No.1, 275-288 https://doi.org/10.2298/GENSR2201275T 21. Xu P.,C. Xu, X.Huang, H.Wang, H. Morabbi Heravi (2021). Genetic diversity and genepool of Salicornia sinus-persica akhani based on retrotransposon-based markers. - Genetika, Vol 53, No.3, 1287 - 1296. https://doi.org/10.2298/GENSR2103287X 22. Yanpeng Z., W. Hongmei, L. Wei, M. Khayatnezhad, Faisal (2021). Genetic diversity and relationships among Salvia species by ISSR markers. - Genetika, Vol 53, No.2, 559-574. https://doi.org/10.2298/GENSR2102559Y 23. Yao X., R. Zhou, M.Farshadfar (2021). Comparison of individual based approaches using RAPD markers for identifying genetic relationships in Erodium (Geranaiceae)- Genetika, Vol 53, No.3, 1229 - 1238 https://doi.org/10.2298/GENSR2103229Y 24. Yin J. (2022). Evaluation of genetic variability Rindera using RAPD markers. - Genetika, Vol 54, No.1, 173-186. https://doi.org/10.2298/GENSR2201173Y 25. Zhang X. and A. Shakoor (2021). Strong genetic differentiation of the Paracaryum species (Boraginaceae) detected by inter-simple sequence repeats (ISSR).- Genetika, Vol 53, No.2, 883-894 https://doi.org/10.2298/GENSR2102883Z 26. Zhang Z., H. Yu, S. Feng, A. A. Minaeifar (2021). Species identification and population structure analysis in Hesperis L. (Brassicaceae). - Genetika, Vol 53, No.3, 1357 - 1368 https://doi.org/10.2298/GENSR2103357Z 27. Zhou Y. and Z. Zheng (2022). Genetic Diversity and inter-relationship among Stellaria L. (Caryophyllaceae) species ISSR markers. - Genetika, Vol 54, No.1, 119-130. https://doi.org/10.2298/GENSR2201119Z In addition, Clarivate provided the publisher with evidence of inappropriate manipulation of citations of five paper published in journal Genetika in journal Bioscenece research: 1. Bi D., D. Chen, M. Khayatnezhad, Z. S. Hashjin, Z. Li, Y. Ma (2021). Genetic response of growth phases for abiotic environmental stress tolerance in cereal crop plants. - Genetika, Vol 53, No.1,393-405 https://doi.org/10.2298/GENSR2101393B 2. Chen W., M. Khayatnezhad, N, Sarhadi (2021). Gene flow and population structure in Allochrusa (Caryophylloideae, caryophyllaceae) with the use of molecular markers- Genetika, Vol 53, No.2, 799-812 https://doi.org/10.2298/GENSR2102799C 3. Jia Y., M. Khayatnezhad, S. Mehri (2020). Population differentiation and gene flow in Erodium cicutarium: a potential medicinal plant- Genetika, Vol 52, No.3, 1127-1144. https://doi.org/10.2298/GENSR2003127J 4. Peng X., M. Khayyatnezhad and L. Joudi Ghezeljehmeidan (2021). RAPD profiling in detecting genetic variation in Stellaria L. (Caryophyllaceae).- Genetika, Vol 53, No.1,349 -362. https://doi.org/10.2298/GENSR2101349P 5. Yin J., M. Khayatnezhad, A. Shakoor (2021). Evaluation of genetic diversity in geranium (Geraniaceae) using RAPD marker.- Genetika, Vol 53, No.1,363 -378. https://doi.org/10.2298/GENSR2101363Y Authors who misused the papers published in Genetika by citing them unjustifiably as well as authors of the cited papers are barred from publishing in that journal in the future and will be blacklisted by the journal. We would like to apologize authors, readers and all scientific community that we are having to make those retractions, and we will take all necessary steps to ensure our editorial and peer review processes keep pace with the evolving threat and advancements in scientific fraud. Snezana Mladenovic Drinic, editor <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2103179B">10.2298/GENSR2103179B</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2102867H">10.2298/GENSR2102867H</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2103081J">10.2298/GENSR2103081J</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2102895L">10.2298/GENSR2102895L</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2102739L">10.2298/GENSR2102739L</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2103369L">10.2298/GENSR2103369L</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2102507L">10.2298/GENSR2102507L</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2103331L">10.2298/GENSR2103331L</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2102651M">10.2298/GENSR2102651M</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2102671M">10.2298/GENSR2102671M</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2102769M">10.2298/GENSR2102769M</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2102837M">10.2298/GENSR2102837M</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2102609N">10.2298/GENSR2102609N</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2201063N">10.2298/GENSR2201063N</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2103193O">10.2298/GENSR2103193O</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2102783Q">10.2298/GENSR2102783Q</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2103287X">10.2298/GENSR2103287X</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2103273G">10.2298/GENSR2103273G</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2201369S">10.2298/GENSR2201369S</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2201275T">10.2298/GENSR2201275T</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2102559Y">10.2298/GENSR2102559Y</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2103229Y">10.2298/GENSR2103229Y</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2201173Y">10.2298/GENSR2201173Y</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2102883Z">10.2298/GENSR2102883Z</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2103357Z">10.2298/GENSR2103357Z</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2201119Z">10.2298/GENSR2201119Z</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2101393B">10.2298/GENSR2101393B</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2102799C">10.2298/GENSR2102799C</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2003127J">10.2298/GENSR2003127J</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2101349P">10.2298/GENSR2101349P</a></b></u> <br><br><font color="red"><b> Link to the retracted article <u><a href="http://dx.doi.org/10.2298/GENSR2101363Y">10.2298/GENSR2101363Y</a></b></u>

O objetivo principal desta pesquisa foi avaliar a capacidade de absorção do conhecimento organizacional, tendo como uma das suas dimensões a comunicação com o ambiente externo. Foi desenvolvida uma pesquisa de caráter quantitativo com cem empresas pertencentes aos setores de comércio e de serviços, localizadas na cidade de Palmas, TO. O questionário aplicado envolveu a utilização de uma escala da capacidade de absorção do conhecimento, desenvolvida por Matusik e Heeley (2005). Os autores avaliam que a capacidade de absorção é composta de múltiplas dimensões: 1) relação da empresa com seu ambiente externo, 2) a estrutura, as rotinas de conhecimentos, e o grupo principal de criação de valor e, 3) absorção de habilidades individuais. Os resultados demonstraram que as empresas pesquisadas possuíam alto grau de predominância de relacionamento com o ambiente.Palavras-chave: Capacidade de Absorção do Conhecimento; Conhecimento; Comunicação com o ambiente externo. ABSTRACTThe main objective of this research was to evaluate the absorption capacity of organizational knowledge, having as one of its dimensions communication with the external environment. One quantitative study with a hundred companies belonging to the trade and service sectors has been developed, located in the city of Palmas, TO. The questionnaire involved the use of a range of absorption capacity of the knowledge developed by Matusik and Heeley (2005). The authors estimate that the absorption capacity is made up of multiple dimensions: 1) the company's relationship with its external environment, 2) the structure, routines of knowledge, and the main group of value creation and, 3) absorption of individual skills . The results showed that the surveyed enterprises had a high degree of dominance relationship with the environment.Keywords: Absorption Capacity of Knowledge; Knowledge; Communication with the external environment. RESUMENEl principal objetivo de esta investigación fue evaluar la capacidad de absorción de conocimiento organizacional, teniendo como una de sus dimensiones de comunicación con el ambiente externo. Un estudio cuantitativo con un centenar de empresas pertenecientes a los sectores de comercio y servicios se ha desarrollado, que se encuentra en la ciudad de Palmas, TO. El cuestionario implicó el uso de una gama de capacidad de absorción del conocimiento desarrollado por Matusik y Heeley (2005). Los autores estiman que la capacidad de absorción se compone de múltiples dimensiones: 1) la relación de la empresa con su entorno externo, 2) la estructura, las rutinas de conocimiento, y el grupo principal de la creación de valor y, 3) la absorción de las capacidades individuales . 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Phosphorus availability is a major limiting for crop production. Bacterial solubilization of insoluble inorganic phosphate has been studied as a means of providing available phosphorus for crop production. Bacterial abilities to solubilize calcium phosphate and rock phosphate have been identified to be related with their abilities to produce gluconic acid and ketogluconic acid. However, there is no information regarding the relationship between bacterial ability to solubilize aluminum phosphate and their ability to produce organic acids. This study was conducted to investigate the relationship between bacterial ability to solubilize calcium and aluminum phosphates with their ability to produce organic acids. Bacterial ability to solubilize calcium and aluminum phosphates were determined as the concentration of soluble phosphate in the filtrate of bacterial cultivation media, while bacterial ability to produce organic acids were assessed from the accumulated organic acids in its. 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