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Books on the topic 'Endpoints'

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Published: 4 June 2021
Last updated: 4 February 2022

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1

Bradshaw, A. D. Alternative endpoints for reclamation. Boca Raton, FL: CRC Press, 1988.

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2

Burzykowski, Tomasz, Geert Molenberghs, and Marc Buyse, eds. The Evaluation of Surrogate Endpoints. New York, NY: Springer New York, 2005. http://dx.doi.org/10.1007/b138566.

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3

Emura, Takeshi, Shigeyuki Matsui, and Virginie Rondeau. Survival Analysis with Correlated Endpoints. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-3516-7.

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4

Rauch, Geraldine, Svenja Schüler, and Meinhard Kieser. Planning and Analyzing Clinical Trials with Composite Endpoints. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-73770-6.

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5

Sozu, Takashi, Tomoyuki Sugimoto, Toshimitsu Hamasaki, and Scott R. Evans. Sample Size Determination in Clinical Trials with Multiple Endpoints. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-22005-5.

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6

Clinical trials: Study design, endpoints and biomarkers, drug safety, FDA and ICH guidelines. Amsterdam: Elsevier/AP, 2012.

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7

Medicine), Roundtable for the Development of Drugs and Vaccines against AIDS (Institute of. Surrogate endpoints in evaluating the effectiveness of drugs against HIV infection and AIDS: September 11-12, 1989 : conference summary. Washington, D.C: National Academy Press, 1990.

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8

Morganroth, Joel, and E. Neil Moore, eds. Use and Approval of Antihypertensive Agents and Surrogate Endpoints for the Approval of Drugs Affecting Antiarrhythmic Heart Failure and Hypolipidemia. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4613-1505-6.

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9

John, Updike. Endpoint and other poems. New York: Alfred A. Knopf, 2009.

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10

John, Updike. Endpoint and Other Poems. New York: Knopf Doubleday Publishing Group, 2009.

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11

John, Updike. Endpoint and other poems. New York: Alfred A. Knopf, 2009.

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12

Workshop on New Approaches, Endpoints and Paradigms for RDAs of Mineral Elements (1995 Grand Forks, N.D.). Workshop on New Approaches, Endpoints and Paradigms for RDAs of Mineral Elements: Proceedings from a workshop held in Grand Forks, ND on September 10-12, 1995. Bethesda, MD: American Institute of Nutrition, 1996.

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13

Bedard, D. Evaluation of the 10-day sediment toxicity test using the midge (Chironomus tentans): The effect of different water-sediment ratios on biological endpoints and water quality. [Toronto]: Ontario Ministry of Environment and Energy, 1996.

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14

Workshop, on New Approaches Endpoints and Paradigms for RDAs of Mineral Elements (1995 Grand Forks N. D. ). Workshop on New Approaches, Endpoints and Paradigms for RDAs of Mineral Elements: Proceedings from a workshop held in Grand Forks, ND on September 10-12, 1995. Bethesda, MD: American Institute of Nutrition, 1996.

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15

The Evaluation Of Surrogate Endpoints. Springer, 2010.

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16

Molenberghs, Geert, Marc Buyse, and Tomasz Burzykowski. The Evaluation of Surrogate Endpoints. Springer, 2009.

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17

Wagner, J. A. Surrogate Endpoints in Medicine (Disease Markers). Ios Pr Inc, 2002.

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18

Downing, G. J. Biomarkers and Surrogate Endpoints: Clinical Research and Applications. Elsevier, 2000.

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19

Rauch, Geraldine, Svenja Schüler, and Meinhard Kieser. Planning and Analyzing Clinical Trials with Composite Endpoints. Springer, 2018.

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20

Rauch, Geraldine, Svenja Schüler, and Meinhard Kieser. Planning and Analyzing Clinical Trials with Composite Endpoints. Springer, 2018.

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21

Evaluation Of Biomarkers And Surrogate Endpoints In Chronic Disease. National Academies Press, 2010.

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22

Emura, Takeshi, Shigeyuki Matsui, and Virginie Rondeau. Survival Analysis with Correlated Endpoints: Joint Frailty-Copula Models. Springer, 2019.

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23

Emura, Takeshi. Survival Analysis with Correlated Endpoints: Joint Frailty-Copula Models. Springer, 2019.

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24

United States. Environmental Protection Agency. Risk Assessment Forum., ed. Generic ecological assessment endpoints (GEAEs) for ecological risk assessment. Washignton, DC: Risk Assessment Forum, U.S. Environmental Protection Agency, 2003.

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25

G, Chapman, and United States. Environmental Protection Agency, eds. Discussion synopsis: Effluent toxicity testing methods and appropriate endpoints. [Washington, D.C.?: U.S. Environmental Protection Agency, 1996.

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26

Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease. Washington, D.C.: National Academies Press, 2010. http://dx.doi.org/10.17226/12869.

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27

(Editor), Tomasz Burzykowski, Geert Molenberghs (Editor), and Marc Buyse (Editor), eds. The Evaluation of Surrogate Endpoints (Statistics for Biology and Health). Springer, 2005.

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28

1941-, Peace Karl E., ed. Design and analysis of clinical trials with time-to-event endpoints. Boca Raton: Chapman & Hall/CRC/Taylor & Francis, 2009.

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29

Design and Analysis of Clinical Trials with Time-to-Event Endpoints. Chapman & Hall/CRC, 2009.

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30

Peace, Karl E. Design and Analysis of Clinical Trials with Time-To-Event Endpoints. Taylor & Francis Group, 2009.

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31

Peace, Karl E., ed. Design and Analysis of Clinical Trials with Time-to-Event Endpoints. Chapman and Hall/CRC, 2009. http://dx.doi.org/10.1201/9781420066401.

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32

Brody, Tom. Clinical Trials: Study Design, Endpoints and Biomarkers, Drug Safety, and FDA and ICH Guidelines. Elsevier Science & Technology Books, 2016.

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33

Jörg, Römbke, and SETAC (Society), eds. Effects of plant protection products on functional endpoints in soil (EPFES), Lisbon, 24-26 April 2002. Pensacola, FL: Society of Environmental Toxicology and Chemistry, 2003.

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34

Hardy, Bruce W., and Kathleen Hall Jamieson. Overcoming Biases in Processing of Time Series Data About Climate. Edited by Kathleen Hall Jamieson, Dan M. Kahan, and Dietram A. Scheufele. Oxford University Press, 2017. http://dx.doi.org/10.1093/oxfordhb/9780190497620.013.43.

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This chapter notes the important ways in which time series data are used in science, explains how trend lines are created and reported, chronicles ways in which they can be misused, documents human biases that lead to overvaluing endpoints in a trend, and outlines ways to minimize that bias. Specifically, this chapter defines trend lines and time series data and explain why and how they matter in science communication. A discussion on cognitive biases that influence interpretations of trend lines, such as endpoint bias and peak and end rule, recency bias, accessibility bias, and extrapolation bias, is offered as are communication tools scientists, journalists, and other science communicators can use to overcome these biases.
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35

Kulkarni, Kunal, James Harrison, Mohamed Baguneid, and Bernard Prendergast, eds. Transplantation. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198729426.003.0030.

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Organ transplantation is now a well-established therapy for patients with end-stage organ failure. Over the last 20 years, the results of transplantation have improved incrementally for many reasons, including better recipient selection, improved anaesthetic and surgical techniques, the introduction of more effective antiviral agents, and better post-transplant immunosuppressive management. The problem of early graft loss from acute rejection is now uncommon, and the main challenges today are chronic allograft rejection and the side effects of non-specific suppression of the immune response. Randomized clinical trials continue to inform and further improve clinical practice. Because transplantation today is largely successful, the traditional endpoints of 1-year patient and graft survival are no longer sufficient, and more sophisticated endpoints are needed that reflect graft function and quality of life after transplantation. This chapter brings together studies which recognize this need for clinical trials which improve practice and focus on more broadly defined endpoints.
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36

American Academy of Environmental Engineers (Corporate Author), David G. Linz (Editor), and David V. Nakles (Editor), eds. Environmentally Acceptable Endpoints in Soil: Risk-Based Approach to Contaminated Site Management Based on Availability of Chemicals in Soil. Amer Academy of Environmental, 1997.

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37

G, Linz David, Nakles David V, and American Academy of Environmental Engineers., eds. Environmentally acceptable endpoints in soil: Risk-based approach to contaminated site management based on availability of chemicals in soil. Annapolis, MD: American Academy of Environmental Engineers, 1997.

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38

Endpoint Security. Addison-Wesley Professional, 2007.

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39

Morganroth, J. Use and Approval of Antihypertensive Agents and Surrogate Endpoints for the Approval of Drugs Affecting Antiarrhythmic Heart Failure and Hypolipidemia. Springer, 2011.

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40

Humane endpoints in animal experiments for biomedical research: Proceedings of the international conference, 22-25 November 1998, Zeist, the Netherlands. London: Royal Society of Medicine Press, 1999.

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41

Guidance Document on the Recognition, Assessment and Use of Clinical Signs as Human Endpoints for Experimental Animals Used in Safety Evaluation. OECD, 2002. http://dx.doi.org/10.1787/9789264078376-en.

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42

Skin Endpoint Titration. 2nd ed. Thieme-Stratton Corp, 1992.

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43

L, Mabry Richard, ed. Skin endpoint titration. 2nd ed. New York: Thieme Medical Publishers, 1994.

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44

Kipnis, Eric, and Benoit Vallet. Tissue perfusion monitoring in the ICU. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0138.

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Resuscitation endpoints have shifted away from restoring normal values of routinely assessed haemodynamic parameters (central venous pressure, mean arterial pressure, cardiac output) towards optimizing parameters that reflect adequate tissue perfusion. Tissue perfusion-based endpoints have changed outcomes, particularly in sepsis. Tissue perfusion can be explored by monitoring the end result of perfusion, namely tissue oxygenation, metabolic markers, and tissue blood flow. Tissue oxygenation can be directly monitored locally through invasive electrodes or non-invasively using light absorbance (pulse oximetry (SpO2) or tissue (StO2)). Global oxygenation may be monitored in blood, either intermittently through blood gas analysis, or continuously with specialized catheters. Central venous saturation (ScvO2) indirectly assesses tissue oxygenation as the net balance between global O2 delivery and uptake, decreasing when delivery does not meet demand. Lactate, a by-product of anaerobic glycolysis, increases when oxygenation is inadequate, and can be measured either globally in blood, or locally in tissues by microdialysis. Likewise, CO2 (a by-product of cellular respiration) and PCO2 can be measured globally in blood or locally in accessible mucosal tissues (sublingual, gastric) by capnography or tonometry. Increasing PCO2 gradients, either tissue-to-arterial or venous-to-arterial, are due to inadequate perfusion. Metabolically, the oxidoreductive status of mitochondria can be assessed locally through NADH fluorescence, which increases in situations of inadequate oxygenation/perfusion. Finally, local tissue blood flow may be measured by laser-Doppler or visualized through intravital microscopic imaging. These perfusion/oxygenation resuscitation endpoints are increasingly used and studied in critical care.
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45

J, Raiten Daniel, and Talbot John M, eds. Clinical trials for the treatment of secondary wasting and cachexia: Selection of appropriate endpoints : proceedings of a workshop, May 22-23, 1997. Bethesda, MD: American Society for Nutritional Sciences, 1999.

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46

J, Raiten Daniel, and Talbot John M, eds. Clinical trials for the treatment of secondary wasting and cachexia: Selection of appropriate endpoints : proceedings of a workshop, May 22-23, 1997. Bethesda, MD: American Society for Nutritional Sciences, 1999.

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47

Peake, Sandra L., and Matthew J. Maiden. Management of septic shock in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0298.

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The management of septic shock is a medical emergency. Following prompt recognition, treatment priorities are haemodynamic resuscitation, empirical antimicrobials, urgent control of the source of infection and monitoring the response to therapy. Haemodynamic resuscitation is focused on maintaining an adequate macrocirculation, while also ensuring adequacy of microcirculatory blood flow to the cells. Intravenous fluids and catecholamines have been the mainstay of therapy. However, the amount and type of fluids, choice of vasoactive medications, and the appropriate resuscitation endpoints have been questioned. Greater awareness of the importance of resuscitating the microcirculation and cell function have led to endpoints such as venous O2 saturation and changes in lactate levels becoming resuscitation targets. Urgent definitive treatment of the infection is also crucial. This requires prompt broad-spectrum empirical antimicrobial therapy, draining infected collections and removing infected medical devices. Despite extensive research, no new therapies have improved survival from septic shock.
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48

Pascual, J. Using Patient-Friendly Composite Endpoints to Measure the Success of Acute Migraine Medications: 4th Annual Migraine Meeting, Budapest, October 2004: Proceedings (European Neurology). Edited by J. Pascual. S. Karger A. G., 2005.

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49

Use and Approval of Antihypertensive Agents and Surrogate Endpoints for the Approval of Antiarrhythmic, Antiheart Failure and Hypolipidemic Agents (Developments in Cardiovascular Medicine). Springer, 1990.

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50

Cassidy, Jim, Donald Bissett, Roy A. J. Spence OBE, Miranda Payne, and Gareth Morris-Stiff. Cancer prevention. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199689842.003.0011.

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Introduces the reader to importance of clinical trials in cancer therapy. Describes the phases of development and some of the “traditional” guidelines for such studies. Focuses particularly on early phase trials of novel compounds. Also describes endpoints used in such trials. Section on quality of life which highlights the growing importance of this aspect of trail design and interpretation
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